NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|270339501|ref|YP_003331583|]
View 

transcriptional regulator ICP4 [Felid alphaherpesvirus 1]

Protein Classification

PHA03307 family protein( domain architecture ID 11476204)

PHA03307 family protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 16-1324 0e+00

transcriptional regulator ICP4; Provisional


:

Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 1326.72  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501   16 RFPQIDLFDLIEDFTDGREEFEFLGDTNSDvesrgRPQDLLYGSQGFLVSPPGDKDEVFFDFGKTPDDVNRVGN------ 89
Cdd:PHA03307    1 SDNAPDLYDLIEAAAEGGEFFPRPPATPGD-----AADDLLSGSQGQLVSDSAELAAVTVVAGAAACDRFEPPTgpppgp 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501   90 -------------PTSGGTKTLTSPRPTRETITSGPTTKPPPPPTIHSAASPETPVPDIIEMLRRV--------QEDLGV 148
Cdd:PHA03307   76 gteapanesrstpTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVgspgpppaASPPAA 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501  149 SESHGRSTSDTETCSHPSNALSITDSSAHSPSSVGVCDVTECDSLGARDYSRGRRSPISVGSMSPGPRRG---------- 218
Cdd:PHA03307  156 GASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGrsaaddagas 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501  219 ---------------------RRSRSGSSSSSSSSSSSGSSSTGSRSSSSSSSSTSRSPSPPAPPNRELKPGTPSPPRPA 277
Cdd:PHA03307  236 ssdssssessgcgwgpenecpLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRAS 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501  278 GEGSPITNDVIASITPQSNVVGSASTTPGATLTDGATLTDGPGDTTPKRRRRRGPLSRPP-------GSRLPRAVRGLLP 350
Cdd:PHA03307  316 SSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPsspaasaGRPTRRRARAAVA 395

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501  351 RAERISERTSVFGIQRPP--------------TTGPLLTPTGEVWPDCDPPCEGRVRYGGIGDSREGLWDAPEIKSAAER 416
Cdd:PHA03307  396 GRARRRDATGRFPAGRPRpspldagaasgafyARYPLLTPSGEPWPGSPPPPPGRVRYGGLGDSRPGLWDAPEVREAAAR 475

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501  417 YAADPGPVPVYVPEMGDSKKQYLALVRLIYESGRDAMAWLQNSKMSGPDQILAQFCQRAIHGPRGHGSFITGSVANPLPH 496
Cdd:PHA03307  476 YEASPGPVPVYVPEMGDSAKQYAALVRLLYTPDREAMGWLQNPKLTGPDQALDQFCQKKFQAPRGSGSFITGSVARPVPH 555

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501  497 VGDAMATMDPLLALPHVTAAVAMSRRYDRTQKTYMLQSLRRAYWDIARPYLLGDHRTDcirsspgiadaipdappktpts 576
Cdd:PHA03307  556 IGDAMAAGNALWALPHAAAAVAMSRRYDRAQKGFLLQSLRRAYAPMAYPENAADTGAG---------------------- 613

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501  577 sdrvlmvsedilallqstlAGGTTRGTGDPTQIPTPGMGGENPRDLAETCTLACTAVFDSLIFHCGGVDRMPGLfeppsm 656
Cdd:PHA03307  614 -------------------AAAPAPAAPRPDAAAAGGASARPLRELADACVLACRAVLEALLEGPDGLSAVPGL------ 668

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501  657 arsfpsvaKYPSPVCPPDALCAHPDVIEAVTARLYSLRDLVELSRIRGgeAPPERLSRDDLQLVVHSLLLVARTLAPLVR 736
Cdd:PHA03307  669 --------AFPRPACPPRALEACPARLESWLRELRDLRDAVYLARLRG--DLPVAGGREERVAAVRAVSLVARTVAPLVR 738

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501  737 YNIDVARKRAPGWNLTRAVFAIPSRVASLMEEVAGTPDPHTPT--------PRATASGNRAGGVTVEEISPPRSSNKMQQ 808
Cdd:PHA03307  739 YSPRRARARASAWDITDALFSNPSLVPAKLAEALALLEPAEPQrgagssppVRAEAAFRRPGRLRRSGPAADAASRTASK 818

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501  809 RRDVHNPVAGG---CDPLQQSPSNFRPLSPHltrpqsSIRCKRKSEPLPRGHASGNLPIDAVRGEEMRAHPPTDAPPPTK 885
Cdd:PHA03307  819 RKSRSHTPDGGsesSGPARPPGAAARPPPAR------SSESSKSKPAAAGGRARGKNGRRRPRPPEPRARPGAAAPPKAA 892

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501  886 KRAGPPRGP-----------LGPMPLGGPSPKGGFRRIPSGDCHTPRPTDAVSSVYCPPEIVAELVDHPLFPEAWRSAIT 954
Cdd:PHA03307  893 AAAPPAGAPaprprpaprvkLGPMPPGGPDPRGGFRRVPPGDLHTPAPSAAALAAYCPPEVVAELVDHPLFPEPWRPALA 972

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501  955 FDPGALATIAARCTGPRRQEGTGLGGLVVSAPLRRASAWMTQIADPEDVKVVVLYNPLPHEHLAHQNPNRDSRHTPAWSE 1034
Cdd:PHA03307  973 FDPEALAEIAARCGGPPPRSGSAFGPLRASGPLRRRAAWMRQIPDPEDVRVVVLYSPLPGEHLFGVPAPDASPGGPAWSP 1052

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501 1035 TKGGLSTLLAALGNRLLSPESHSWAGNWSGPPDIRRLNAQGVLLLSTGDLAFAGCVEYLCLRLGSARRRLIVFDTVDPED 1114
Cdd:PHA03307 1053 ERGGLSFLLAALGNRLCLPDSHAWAGNWTGAPDVSALNAQGVLLLSTRDLAFAGAVEYLCLRLGSARRRLIVLDTVDPED 1132

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501 1115 WPATGPAVSHYHLYIRATVTPTAYCAVRWPALEDLSRAVLTSSAIFGPGSFARVEAAFERLYPNCDGLRLCASGNVGYTV 1194
Cdd:PHA03307 1133 WPADGPAVSQYHVYLRCAVLPRAQCAVRWPAARDLARAVLTSSRVFGPGLFARVEAAFARLYPDAPPLRLCRGANVRYTV 1212

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501 1195 RTDAGDRTPVPMLPREYRQRVLPAYDGCKDMEAQSAGLKLGEPDFVDGAAHSHRACNRWGLGAPLRPVYLATGRRALAST 1274
Cdd:PHA03307 1213 RTRLGPRTRVPLPPREYRQAVLPALDGCKDMAAQAEGLGLGAPDFLEGEAHSHRAANRWGLGAPLRPVYLAEGRRAAIAG 1292

                        1370      1380      1390      1400      1410
                  ....*....|....*....|....*....|....*....|....*....|
gi 270339501 1275 dPTRIPAVVRAFCRTALLAPDTEAPPLILTPADPQSAIIENIPGVTWDSG 1324
Cdd:PHA03307 1293 -PDELPAVVRAFCRAALLEPDPEAPPLVLPPSAAAEAAHARAPRVTWAKS 1341
 
Name Accession Description Interval E-value
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 16-1324 0e+00

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 1326.72  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501   16 RFPQIDLFDLIEDFTDGREEFEFLGDTNSDvesrgRPQDLLYGSQGFLVSPPGDKDEVFFDFGKTPDDVNRVGN------ 89
Cdd:PHA03307    1 SDNAPDLYDLIEAAAEGGEFFPRPPATPGD-----AADDLLSGSQGQLVSDSAELAAVTVVAGAAACDRFEPPTgpppgp 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501   90 -------------PTSGGTKTLTSPRPTRETITSGPTTKPPPPPTIHSAASPETPVPDIIEMLRRV--------QEDLGV 148
Cdd:PHA03307   76 gteapanesrstpTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVgspgpppaASPPAA 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501  149 SESHGRSTSDTETCSHPSNALSITDSSAHSPSSVGVCDVTECDSLGARDYSRGRRSPISVGSMSPGPRRG---------- 218
Cdd:PHA03307  156 GASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGrsaaddagas 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501  219 ---------------------RRSRSGSSSSSSSSSSSGSSSTGSRSSSSSSSSTSRSPSPPAPPNRELKPGTPSPPRPA 277
Cdd:PHA03307  236 ssdssssessgcgwgpenecpLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRAS 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501  278 GEGSPITNDVIASITPQSNVVGSASTTPGATLTDGATLTDGPGDTTPKRRRRRGPLSRPP-------GSRLPRAVRGLLP 350
Cdd:PHA03307  316 SSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPsspaasaGRPTRRRARAAVA 395

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501  351 RAERISERTSVFGIQRPP--------------TTGPLLTPTGEVWPDCDPPCEGRVRYGGIGDSREGLWDAPEIKSAAER 416
Cdd:PHA03307  396 GRARRRDATGRFPAGRPRpspldagaasgafyARYPLLTPSGEPWPGSPPPPPGRVRYGGLGDSRPGLWDAPEVREAAAR 475

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501  417 YAADPGPVPVYVPEMGDSKKQYLALVRLIYESGRDAMAWLQNSKMSGPDQILAQFCQRAIHGPRGHGSFITGSVANPLPH 496
Cdd:PHA03307  476 YEASPGPVPVYVPEMGDSAKQYAALVRLLYTPDREAMGWLQNPKLTGPDQALDQFCQKKFQAPRGSGSFITGSVARPVPH 555

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501  497 VGDAMATMDPLLALPHVTAAVAMSRRYDRTQKTYMLQSLRRAYWDIARPYLLGDHRTDcirsspgiadaipdappktpts 576
Cdd:PHA03307  556 IGDAMAAGNALWALPHAAAAVAMSRRYDRAQKGFLLQSLRRAYAPMAYPENAADTGAG---------------------- 613

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501  577 sdrvlmvsedilallqstlAGGTTRGTGDPTQIPTPGMGGENPRDLAETCTLACTAVFDSLIFHCGGVDRMPGLfeppsm 656
Cdd:PHA03307  614 -------------------AAAPAPAAPRPDAAAAGGASARPLRELADACVLACRAVLEALLEGPDGLSAVPGL------ 668

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501  657 arsfpsvaKYPSPVCPPDALCAHPDVIEAVTARLYSLRDLVELSRIRGgeAPPERLSRDDLQLVVHSLLLVARTLAPLVR 736
Cdd:PHA03307  669 --------AFPRPACPPRALEACPARLESWLRELRDLRDAVYLARLRG--DLPVAGGREERVAAVRAVSLVARTVAPLVR 738

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501  737 YNIDVARKRAPGWNLTRAVFAIPSRVASLMEEVAGTPDPHTPT--------PRATASGNRAGGVTVEEISPPRSSNKMQQ 808
Cdd:PHA03307  739 YSPRRARARASAWDITDALFSNPSLVPAKLAEALALLEPAEPQrgagssppVRAEAAFRRPGRLRRSGPAADAASRTASK 818

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501  809 RRDVHNPVAGG---CDPLQQSPSNFRPLSPHltrpqsSIRCKRKSEPLPRGHASGNLPIDAVRGEEMRAHPPTDAPPPTK 885
Cdd:PHA03307  819 RKSRSHTPDGGsesSGPARPPGAAARPPPAR------SSESSKSKPAAAGGRARGKNGRRRPRPPEPRARPGAAAPPKAA 892

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501  886 KRAGPPRGP-----------LGPMPLGGPSPKGGFRRIPSGDCHTPRPTDAVSSVYCPPEIVAELVDHPLFPEAWRSAIT 954
Cdd:PHA03307  893 AAAPPAGAPaprprpaprvkLGPMPPGGPDPRGGFRRVPPGDLHTPAPSAAALAAYCPPEVVAELVDHPLFPEPWRPALA 972

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501  955 FDPGALATIAARCTGPRRQEGTGLGGLVVSAPLRRASAWMTQIADPEDVKVVVLYNPLPHEHLAHQNPNRDSRHTPAWSE 1034
Cdd:PHA03307  973 FDPEALAEIAARCGGPPPRSGSAFGPLRASGPLRRRAAWMRQIPDPEDVRVVVLYSPLPGEHLFGVPAPDASPGGPAWSP 1052

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501 1035 TKGGLSTLLAALGNRLLSPESHSWAGNWSGPPDIRRLNAQGVLLLSTGDLAFAGCVEYLCLRLGSARRRLIVFDTVDPED 1114
Cdd:PHA03307 1053 ERGGLSFLLAALGNRLCLPDSHAWAGNWTGAPDVSALNAQGVLLLSTRDLAFAGAVEYLCLRLGSARRRLIVLDTVDPED 1132

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501 1115 WPATGPAVSHYHLYIRATVTPTAYCAVRWPALEDLSRAVLTSSAIFGPGSFARVEAAFERLYPNCDGLRLCASGNVGYTV 1194
Cdd:PHA03307 1133 WPADGPAVSQYHVYLRCAVLPRAQCAVRWPAARDLARAVLTSSRVFGPGLFARVEAAFARLYPDAPPLRLCRGANVRYTV 1212

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501 1195 RTDAGDRTPVPMLPREYRQRVLPAYDGCKDMEAQSAGLKLGEPDFVDGAAHSHRACNRWGLGAPLRPVYLATGRRALAST 1274
Cdd:PHA03307 1213 RTRLGPRTRVPLPPREYRQAVLPALDGCKDMAAQAEGLGLGAPDFLEGEAHSHRAANRWGLGAPLRPVYLAEGRRAAIAG 1292

                        1370      1380      1390      1400      1410
                  ....*....|....*....|....*....|....*....|....*....|
gi 270339501 1275 dPTRIPAVVRAFCRTALLAPDTEAPPLILTPADPQSAIIENIPGVTWDSG 1324
Cdd:PHA03307 1293 -PDELPAVVRAFCRAALLEPDPEAPPLVLPPSAAAEAAHARAPRVTWAKS 1341
Herpes_ICP4_C pfam03585
Herpesvirus ICP4-like protein C-terminal region; The immediate-early protein ICP4 ...
 907-1331 9.29e-158

Herpesvirus ICP4-like protein C-terminal region; The immediate-early protein ICP4 (infected-cell polypeptide 4) is required for efficient transcription of early and late viral genes and is thus essential for productive infection. ICP4 is a large phosphoprotein that binds DNA in a sequence specific manner as a homodimer. ICP4 represses transcription from LAT, ICP4 and ORF-P that have high-affinity a ICP4 binding site that spans the transcription initiation site. ICP4 proteins have two highly conserved regions, this family contains the C-terminal region that probably acts as an enhancer for the N-terminal region.


Pssm-ID: 281570  Cd Length: 444  Bit Score: 482.96  E-value: 9.29e-158
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501   907 GGFRRIPSGDCHTPRPTDAVSSVYCPPEIVAELVDHPLFPEAWRSAITFDPGALATIAARCTGPRRQEGTG--------- 977
Cdd:pfam03585    1 GGFRRFPVGTVHTQTPPQSALNAYCPPGAFAELVDFPLFPEPWRPALRFDPEALADIAARVANALPGGGDYnsneiitsa 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501   978 ----LGGLVVSAPLRRASAWMTQIADPEDVKVVVLYNPLPHEHLAhQNPNRDSrhTPAWSETKGGLSTLLAALGNRLLSP 1053
Cdd:pfam03585   81 asraFGPPTATSKLRRRTAWMRQIPDPEDVRIVVLYSPLPGEDLF-CVPAPDT--PPKWSNKRGGLSFLLAALSNRLCLP 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501  1054 ESHSWAGNWSGPPDIRRLNAQGVLLLSTGDLAFAGCVEYLCLRLGSARRRLIVFDTVDPEDWPATGPAVSHYHLYIRATV 1133
Cdd:pfam03585  158 KTSAWAGNWTGAPDVSALTAMGVLLLSTRDLAFAGAVEYLGRQCMKRKRRLIVMDTVEDRYWPPDGPAISEEHTYMKCII 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501  1134 TPTAYCAVRWPALEDLSRAVLTSSAIFGPGSFARVEAAFERLYPNCDGLRLCASGNVGYTVRTDAGDRTPVPMLPREYRQ 1213
Cdd:pfam03585  238 SPRSQCCVRWPGLLDLGRTVIASRRVFGPLTFARLEQAYAELYPEDSPLNLCRGGNVRYTVETRLGPVTCVPTSPREYRA 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501  1214 RVLPAYDGCKDMEAQSAGLKLGEPDFVDGAAHSHRACNRWGLGAPLRPVYLATGRRALASTDPTRIPAVVRAFCRTALLA 1293
Cdd:pfam03585  318 AVLPVFDGCKDLARQSRGLGLGAPDFLCEEAHSHRAARRWGLGAPLRPVYVIEGRMNAIAGPSFLHVPTARNFCRSALLE 397

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*..
gi 270339501  1294 PDTEAPPLILTP---------ADPQSAIIENIPGVTWDSGFGKQETV 1331
Cdd:pfam03585  398 PDPEARPLVLHIpegtcsalaEDMVASALPPCPRITWGQGFGHEEGG 444
 
Name Accession Description Interval E-value
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 16-1324 0e+00

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 1326.72  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501   16 RFPQIDLFDLIEDFTDGREEFEFLGDTNSDvesrgRPQDLLYGSQGFLVSPPGDKDEVFFDFGKTPDDVNRVGN------ 89
Cdd:PHA03307    1 SDNAPDLYDLIEAAAEGGEFFPRPPATPGD-----AADDLLSGSQGQLVSDSAELAAVTVVAGAAACDRFEPPTgpppgp 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501   90 -------------PTSGGTKTLTSPRPTRETITSGPTTKPPPPPTIHSAASPETPVPDIIEMLRRV--------QEDLGV 148
Cdd:PHA03307   76 gteapanesrstpTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVgspgpppaASPPAA 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501  149 SESHGRSTSDTETCSHPSNALSITDSSAHSPSSVGVCDVTECDSLGARDYSRGRRSPISVGSMSPGPRRG---------- 218
Cdd:PHA03307  156 GASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGrsaaddagas 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501  219 ---------------------RRSRSGSSSSSSSSSSSGSSSTGSRSSSSSSSSTSRSPSPPAPPNRELKPGTPSPPRPA 277
Cdd:PHA03307  236 ssdssssessgcgwgpenecpLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRAS 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501  278 GEGSPITNDVIASITPQSNVVGSASTTPGATLTDGATLTDGPGDTTPKRRRRRGPLSRPP-------GSRLPRAVRGLLP 350
Cdd:PHA03307  316 SSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPsspaasaGRPTRRRARAAVA 395

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501  351 RAERISERTSVFGIQRPP--------------TTGPLLTPTGEVWPDCDPPCEGRVRYGGIGDSREGLWDAPEIKSAAER 416
Cdd:PHA03307  396 GRARRRDATGRFPAGRPRpspldagaasgafyARYPLLTPSGEPWPGSPPPPPGRVRYGGLGDSRPGLWDAPEVREAAAR 475

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501  417 YAADPGPVPVYVPEMGDSKKQYLALVRLIYESGRDAMAWLQNSKMSGPDQILAQFCQRAIHGPRGHGSFITGSVANPLPH 496
Cdd:PHA03307  476 YEASPGPVPVYVPEMGDSAKQYAALVRLLYTPDREAMGWLQNPKLTGPDQALDQFCQKKFQAPRGSGSFITGSVARPVPH 555

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501  497 VGDAMATMDPLLALPHVTAAVAMSRRYDRTQKTYMLQSLRRAYWDIARPYLLGDHRTDcirsspgiadaipdappktpts 576
Cdd:PHA03307  556 IGDAMAAGNALWALPHAAAAVAMSRRYDRAQKGFLLQSLRRAYAPMAYPENAADTGAG---------------------- 613

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501  577 sdrvlmvsedilallqstlAGGTTRGTGDPTQIPTPGMGGENPRDLAETCTLACTAVFDSLIFHCGGVDRMPGLfeppsm 656
Cdd:PHA03307  614 -------------------AAAPAPAAPRPDAAAAGGASARPLRELADACVLACRAVLEALLEGPDGLSAVPGL------ 668

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501  657 arsfpsvaKYPSPVCPPDALCAHPDVIEAVTARLYSLRDLVELSRIRGgeAPPERLSRDDLQLVVHSLLLVARTLAPLVR 736
Cdd:PHA03307  669 --------AFPRPACPPRALEACPARLESWLRELRDLRDAVYLARLRG--DLPVAGGREERVAAVRAVSLVARTVAPLVR 738

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501  737 YNIDVARKRAPGWNLTRAVFAIPSRVASLMEEVAGTPDPHTPT--------PRATASGNRAGGVTVEEISPPRSSNKMQQ 808
Cdd:PHA03307  739 YSPRRARARASAWDITDALFSNPSLVPAKLAEALALLEPAEPQrgagssppVRAEAAFRRPGRLRRSGPAADAASRTASK 818

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501  809 RRDVHNPVAGG---CDPLQQSPSNFRPLSPHltrpqsSIRCKRKSEPLPRGHASGNLPIDAVRGEEMRAHPPTDAPPPTK 885
Cdd:PHA03307  819 RKSRSHTPDGGsesSGPARPPGAAARPPPAR------SSESSKSKPAAAGGRARGKNGRRRPRPPEPRARPGAAAPPKAA 892

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501  886 KRAGPPRGP-----------LGPMPLGGPSPKGGFRRIPSGDCHTPRPTDAVSSVYCPPEIVAELVDHPLFPEAWRSAIT 954
Cdd:PHA03307  893 AAAPPAGAPaprprpaprvkLGPMPPGGPDPRGGFRRVPPGDLHTPAPSAAALAAYCPPEVVAELVDHPLFPEPWRPALA 972

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501  955 FDPGALATIAARCTGPRRQEGTGLGGLVVSAPLRRASAWMTQIADPEDVKVVVLYNPLPHEHLAHQNPNRDSRHTPAWSE 1034
Cdd:PHA03307  973 FDPEALAEIAARCGGPPPRSGSAFGPLRASGPLRRRAAWMRQIPDPEDVRVVVLYSPLPGEHLFGVPAPDASPGGPAWSP 1052

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501 1035 TKGGLSTLLAALGNRLLSPESHSWAGNWSGPPDIRRLNAQGVLLLSTGDLAFAGCVEYLCLRLGSARRRLIVFDTVDPED 1114
Cdd:PHA03307 1053 ERGGLSFLLAALGNRLCLPDSHAWAGNWTGAPDVSALNAQGVLLLSTRDLAFAGAVEYLCLRLGSARRRLIVLDTVDPED 1132

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501 1115 WPATGPAVSHYHLYIRATVTPTAYCAVRWPALEDLSRAVLTSSAIFGPGSFARVEAAFERLYPNCDGLRLCASGNVGYTV 1194
Cdd:PHA03307 1133 WPADGPAVSQYHVYLRCAVLPRAQCAVRWPAARDLARAVLTSSRVFGPGLFARVEAAFARLYPDAPPLRLCRGANVRYTV 1212

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501 1195 RTDAGDRTPVPMLPREYRQRVLPAYDGCKDMEAQSAGLKLGEPDFVDGAAHSHRACNRWGLGAPLRPVYLATGRRALAST 1274
Cdd:PHA03307 1213 RTRLGPRTRVPLPPREYRQAVLPALDGCKDMAAQAEGLGLGAPDFLEGEAHSHRAANRWGLGAPLRPVYLAEGRRAAIAG 1292

                        1370      1380      1390      1400      1410
                  ....*....|....*....|....*....|....*....|....*....|
gi 270339501 1275 dPTRIPAVVRAFCRTALLAPDTEAPPLILTPADPQSAIIENIPGVTWDSG 1324
Cdd:PHA03307 1293 -PDELPAVVRAFCRAALLEPDPEAPPLVLPPSAAAEAAHARAPRVTWAKS 1341
Herpes_ICP4_C pfam03585
Herpesvirus ICP4-like protein C-terminal region; The immediate-early protein ICP4 ...
 907-1331 9.29e-158

Herpesvirus ICP4-like protein C-terminal region; The immediate-early protein ICP4 (infected-cell polypeptide 4) is required for efficient transcription of early and late viral genes and is thus essential for productive infection. ICP4 is a large phosphoprotein that binds DNA in a sequence specific manner as a homodimer. ICP4 represses transcription from LAT, ICP4 and ORF-P that have high-affinity a ICP4 binding site that spans the transcription initiation site. ICP4 proteins have two highly conserved regions, this family contains the C-terminal region that probably acts as an enhancer for the N-terminal region.


Pssm-ID: 281570  Cd Length: 444  Bit Score: 482.96  E-value: 9.29e-158
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501   907 GGFRRIPSGDCHTPRPTDAVSSVYCPPEIVAELVDHPLFPEAWRSAITFDPGALATIAARCTGPRRQEGTG--------- 977
Cdd:pfam03585    1 GGFRRFPVGTVHTQTPPQSALNAYCPPGAFAELVDFPLFPEPWRPALRFDPEALADIAARVANALPGGGDYnsneiitsa 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501   978 ----LGGLVVSAPLRRASAWMTQIADPEDVKVVVLYNPLPHEHLAhQNPNRDSrhTPAWSETKGGLSTLLAALGNRLLSP 1053
Cdd:pfam03585   81 asraFGPPTATSKLRRRTAWMRQIPDPEDVRIVVLYSPLPGEDLF-CVPAPDT--PPKWSNKRGGLSFLLAALSNRLCLP 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501  1054 ESHSWAGNWSGPPDIRRLNAQGVLLLSTGDLAFAGCVEYLCLRLGSARRRLIVFDTVDPEDWPATGPAVSHYHLYIRATV 1133
Cdd:pfam03585  158 KTSAWAGNWTGAPDVSALTAMGVLLLSTRDLAFAGAVEYLGRQCMKRKRRLIVMDTVEDRYWPPDGPAISEEHTYMKCII 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501  1134 TPTAYCAVRWPALEDLSRAVLTSSAIFGPGSFARVEAAFERLYPNCDGLRLCASGNVGYTVRTDAGDRTPVPMLPREYRQ 1213
Cdd:pfam03585  238 SPRSQCCVRWPGLLDLGRTVIASRRVFGPLTFARLEQAYAELYPEDSPLNLCRGGNVRYTVETRLGPVTCVPTSPREYRA 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501  1214 RVLPAYDGCKDMEAQSAGLKLGEPDFVDGAAHSHRACNRWGLGAPLRPVYLATGRRALASTDPTRIPAVVRAFCRTALLA 1293
Cdd:pfam03585  318 AVLPVFDGCKDLARQSRGLGLGAPDFLCEEAHSHRAARRWGLGAPLRPVYVIEGRMNAIAGPSFLHVPTARNFCRSALLE 397

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*..
gi 270339501  1294 PDTEAPPLILTP---------ADPQSAIIENIPGVTWDSGFGKQETV 1331
Cdd:pfam03585  398 PDPEARPLVLHIpegtcsalaEDMVASALPPCPRITWGQGFGHEEGG 444
Herpes_ICP4_N pfam03584
Herpesvirus ICP4-like protein N-terminal region; The immediate-early protein ICP4 ...
 386-545 1.67e-59

Herpesvirus ICP4-like protein N-terminal region; The immediate-early protein ICP4 (infected-cell polypeptide 4) is required for efficient transcription of early and late viral genes and is thus essential for productive infection. ICP4 is a large phosphoprotein that binds DNA in a sequence specific manner as a homodimer. ICP4 represses transcription from LAT, ICP4 and ORF-P that have high-affinity a ICP4 binding site that spans the transcription initiation site. ICP4 proteins have two highly conserved regions, this family contains the N-terminal region that contains sites for DNA binding and homodimerization.


Pssm-ID: 367571 [Multi-domain]  Cd Length: 163  Bit Score: 201.59  E-value: 1.67e-59
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501   386 PPCEGRVRYGGIGDSREGLWDAPEIKSAAERYAADPGPVPVYVPEMGDSKKQYLALVRLIYESGRDAMAWLQNSKMSGPD 465
Cdd:pfam03584    1 PPPPGRVLYGGLGDSRPGLWGAPEVREARARFEASGAPAPVYVPELGDAAQQYAALVNLLYTPDAEPLGWLQNPRLNPGD 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501   466 QILAQFCQRAIHGPRGHGSFITGSVANPLPHVGDAMATMDPLLALPHVTAAVAMSRRYDRTQKTYMLQSLRRAYWDIARP 545
Cdd:pfam03584   81 VALNQICQKISGAARNSGSAVTGSVARAVPHIGYAMAAGRALWALPHAAAAVAMSRRYDRAQKTFLLTSLRRAYAPLAFP 160
PHA03308 PHA03308
transcriptional regulator ICP4; Provisional
 386-1154 1.82e-15

transcriptional regulator ICP4; Provisional


Pssm-ID: 165563 [Multi-domain]  Cd Length: 1463  Bit Score: 82.16  E-value: 1.82e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501  386 PPCEGRVRYGGigDSREGLWDAPEIKSAAERYAADPGPVPVYVPEMGDSKKQYLALVR--LIYESGRDAMAWlQNSKMSG 463
Cdd:PHA03308  358 PPSRGQVYHGS--GYRQSLVDDPQVREAAAEFHANPKSASVYLEEYGMPVEQLERLVEefMVHPLSRVSYGY-GGPKLSP 434

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501  464 PDQILAQFCqrAIHGP-RGHGSFITGSVANPLPHVGDAMATMDPLLALPHVTAAVAMSRRYDRTQKTYMLQSLRRAYwdi 542
Cdd:PHA03308  435 RDKRLCELC--ALRGPgSSEGGLSRSAVPTCLPHVAHAMRDGRVSLALPHLTELVRVCRRYDHPQKTYLLAALRRAF--- 509

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501  543 aRPYLLGDHRTDcirssPGIADAIPDAPpktptssdrVLMVSEDILALLQSTLAGGTTRGTGDPTQIPTPGMGGEnprdl 622
Cdd:PHA03308  510 -VPFVFPGAAVD-----PTAASASGDHP---------VLVGARRIARATRELEAAAKEPPAATPEKLSSSALLRH----- 569

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501  623 AETCTLACTAVFDSLIfhcgGVDRMPGLFEPpsmARSFPSVakYPSPVCPPDALCAHPDVIEAVTARLYslrdlvelSRI 702
Cdd:PHA03308  570 TRTCIVAAADLMAALT----AIDCPPVTINP---AKRRPDL--YQALSRAPKTVFTWERAMPYCAASLW--------SRL 632

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501  703 RGGEAPPErlSRDDLQLVVHSLLLVARTLAPL----VRYNIDVArkrAPGWNLTRAVFAIPSRVAS--LMEEVAGTPDPH 776
Cdd:PHA03308  633 VIGSLPLP--STDDVTLLVEAMEAAVGVLGCSdegdVRPSIAYA---ASGWRMIATMLGDDSAPGSehVTDDCPADDDTH 707

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501  777 TPTPRATASGNRAggvTVEEISPPRSSNKMQQRRDVHNPVAG-GCDP--LQQSPSN---------------FRPLSPHLT 838
Cdd:PHA03308  708 HHDRRKRRGGRRT---TCRYDLPPGTPDRAAHLLLYGSPGGGdGAEPsaAQESPANpwprappcdeqeplsVSPYGPEPD 784

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501  839 RP-----QSSIRCKRKS-----EPLPRGHASGNLPidAVRGeemrahPPTDAPP--PTKKRAGPPRGPLGPMPLGGPSPk 906
Cdd:PHA03308  785 RPpdddfETRKGLKRKSsedhaDPIPEGNATKKTC--GLQG------LPDSLPPavPETDRDNPLLPPCPITPEGPPCP- 855

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501  907 ggfrriPSGDCHTPR-PTDAVSSVYCPPEIVAELV-DHPLFPeawrsAITFDPGALATIAARCTGPR-RQEGTGLGGLVV 983
Cdd:PHA03308  856 ------PREEPQQPQePQEPQSPSFHISEIGEALFhSTPVSP-----TILFAPEGFIPNQGDVYRPHgKNLGVALSAGEP 924

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501  984 SAPLRRASAWMTQIAD-----------------PEDVKVVVLYNPLP-HEHLAHQNP-NRDSR----HTPAW-------- 1032
Cdd:PHA03308  925 YVPAHRARPALERLANylrglssgpagsysatgPADWLPAFARDPVAlGEFCKRISPvNRGGRcvleERLSWtlrhpadk 1004

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501 1033 --------SETKGG----LSTLLAALGNRLLSPESHSWAGNWSG------PPDiRRLNAQGVLLLSTGDLAFAGCVEYLC 1094
Cdd:PHA03308 1005 iydliilvSERAPGefleRAYAYAALCGRACMPGGACWPESWTRgeypyiPPD-EKDPGRSVAILCTTDLGYAGAVEWML 1083

                         810       820       830       840       850       860
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 270339501 1095 LR-LGSARRRLIVFDTVDPEDWPA-TGPAVSHYH---LYIRATVTPTAYCAVRW--PALEDLSRAVL 1154
Cdd:PHA03308 1084 ERaLSTSGRACVVVDARDPGDEDSrSGPRIPTGRrgvVYARTSPPSHAYLVKLFtgPAAERLERGGL 1150
PHA03309 PHA03309
transcriptional regulator ICP4; Provisional
 347-545 7.93e-09

transcriptional regulator ICP4; Provisional


Pssm-ID: 165564 [Multi-domain]  Cd Length: 2033  Bit Score: 60.64  E-value: 7.93e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501  347 GLLPRAERISERTSVfGIQRPPTTGPLLTPTGEVWPD----CDPPCEGRVRYGGIGdSREGLWDAPEIKSAAERYAADPG 422
Cdd:PHA03309  590 GSLPELPDMCPRVAV-GIISHALAVDLSAPGGRITVDeallPKPPAADYVYYGKTG-YRPSMAAHPDVRRAAEEFSASDA 667

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501  423 PVPVYVPEMGDSKKQYLALVR--LIYESGRDAMAWlQNSKMSGPDQILAQFC-----------QRAIHGPRGHGSFITG- 488
Cdd:PHA03309  668 AARVYVEEFGMAVEQHERLVAefMLQPLSRVSHSY-GGSRLNKTEKNLCKIClppdggddrdgGGKSRGGRGGGSKDASr 746

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 270339501  489 -SVANPLPHVGDAMATMDPLLALPHVTAAVAMSRRYDRTQKTYMLQSLRRAYWDIARP 545
Cdd:PHA03309  747 tAMATGVPHIVHAMRDGRAALALPHLMDVIRVCRRYDASQKTYLLSCLRLAFAPLVFP 804
PHA03247 PHA03247
large tegument protein UL36; Provisional
 653-1033 2.09e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 52.63  E-value: 2.09e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501  653 PPSMARSFPSVAKYPSPVCPPDAlcaHPDVIEAVTARLYSLRDLVELSRIRGGEAPPERLSRDDLQLVVHSLLLVARTLA 732
Cdd:PHA03247 2627 PPPSPSPAANEPDPHPPPTVPPP---ERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPP 2703

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501  733 PlvrynidvarKRAPGWNLTRAVFAIPSRVASLMEEVAGTPDPHTPTPRATASGNRAGGVTVEEISPPRSSNkmqqrrdv 812
Cdd:PHA03247 2704 P----------PPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAG-------- 2765

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501  813 hnpvaggcdPLQQSPSNFRPLSP--HLTRPQ-SSIRCKRKSEPLPRGHASGNLPIDA-VRGEEMRAHPPTDAPPPTKKRA 888
Cdd:PHA03247 2766 ---------PPAPAPPAAPAAGPprRLTRPAvASLSESRESLPSPWDPADPPAAVLApAAALPPAASPAGPLPPPTSAQP 2836

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270339501  889 GPPRGPLGPMPL-----GGPSPKGGFRRIPSGDCHTPRPTD---------AVSSVYCPPEIVAELVDHPLFPEAWRSAIT 954
Cdd:PHA03247 2837 TAPPPPPGPPPPslplgGSVAPGGDVRRRPPSRSPAAKPAAparppvrrlARPAVSRSTESFALPPDQPERPPQPQAPPP 2916

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 270339501  955 FDPGALATIAARCTGPRRQEGTGLGGLVVSAPLRRASAWMTQIADPEDVKVVVLYNPLPHEHLAhqnPNRDSRHTPAWS 1033
Cdd:PHA03247 2917 PQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVP---QPAPSREAPASS 2992
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH