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Conserved domains on  [gi|992329484|ref|YP_009227888|]
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NADH dehydrogenase subunit 2 (mitochondrion) [Armatobalanus allium]

Protein Classification

NADH dehydrogenase subunit 2( domain architecture ID 11475933)

NADH dehydrogenase subunit 2 is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
 1-332 5.21e-69

NADH dehydrogenase subunit 2; Provisional


:

Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 218.54  E-value: 5.21e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484   1 MNLYFPPFMYSFFLFSGTLISISSSSLFGMWMGLEINLMSFIPMIINlESNKKSGEAAIKYFLIQAMASTVVIFSSLMFF 80
Cdd:MTH00160   1 MMMNSSKLLFLSTLIMGTLISISSNSWFGAWMGLEINLLSFIPLISN-KKNLMSSESSLKYFLIQALASIILLFSIILNM 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484  81 LFSgYSFSFTPNIIITLALCMKLGMAPFHFWFPDVIEGLNWINSLILLTWQKISPLVILSLFFYPYTLIAMALISAIMGA 160
Cdd:MTH00160  80 LNL-MLFNNISSMLINSSLLLKLGAAPFHFWFPEVMEGLSWINCFILMTWQKIAPLILLSYLINNNFIIIIIILSAIIGA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484 161 ISGINQTSMRKILAFSSISHLGWMTSIMYFNSGLWLNYFIIYSFTSFILCFSFWMLNLNYFSQLTLSQNMN--EKFMIFI 238
Cdd:MTH00160 159 IGGLNQTSLRKILAYSSINHLGWMLSSMMISENLWLIYFLIYSIISLSIILLFNKFNIFFLNQLFNSNNKSkkIKFLLFL 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484 239 NLLSLGGLPPLLGFLPKWIAM--MVISNNFPVLIILIMSSLITLYFYTRICFSTFTLYMQSMTWYQKSKTSKNFFMMSIL 316
Cdd:MTH00160 239 NLLSLGGLPPFLGFLPKWIIIqlLISNNMFFLLFILIMSSLITLYFYLRISYSSLMLNYNKNKWNLKKKKNKFSLILNFL 318

                        330
                 ....*....|....*.
gi 992329484 317 TFFSLIGIVPLSLINI 332
Cdd:MTH00160 319 SFISLFGLILSSLLFL 334
 
Name Accession Description Interval E-value
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
 1-332 5.21e-69

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 218.54  E-value: 5.21e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484   1 MNLYFPPFMYSFFLFSGTLISISSSSLFGMWMGLEINLMSFIPMIINlESNKKSGEAAIKYFLIQAMASTVVIFSSLMFF 80
Cdd:MTH00160   1 MMMNSSKLLFLSTLIMGTLISISSNSWFGAWMGLEINLLSFIPLISN-KKNLMSSESSLKYFLIQALASIILLFSIILNM 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484  81 LFSgYSFSFTPNIIITLALCMKLGMAPFHFWFPDVIEGLNWINSLILLTWQKISPLVILSLFFYPYTLIAMALISAIMGA 160
Cdd:MTH00160  80 LNL-MLFNNISSMLINSSLLLKLGAAPFHFWFPEVMEGLSWINCFILMTWQKIAPLILLSYLINNNFIIIIIILSAIIGA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484 161 ISGINQTSMRKILAFSSISHLGWMTSIMYFNSGLWLNYFIIYSFTSFILCFSFWMLNLNYFSQLTLSQNMN--EKFMIFI 238
Cdd:MTH00160 159 IGGLNQTSLRKILAYSSINHLGWMLSSMMISENLWLIYFLIYSIISLSIILLFNKFNIFFLNQLFNSNNKSkkIKFLLFL 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484 239 NLLSLGGLPPLLGFLPKWIAM--MVISNNFPVLIILIMSSLITLYFYTRICFSTFTLYMQSMTWYQKSKTSKNFFMMSIL 316
Cdd:MTH00160 239 NLLSLGGLPPFLGFLPKWIIIqlLISNNMFFLLFILIMSSLITLYFYLRISYSSLMLNYNKNKWNLKKKKNKFSLILNFL 318

                        330
                 ....*....|....*.
gi 992329484 317 TFFSLIGIVPLSLINI 332
Cdd:MTH00160 319 SFISLFGLILSSLLFL 334
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 28-209 1.93e-18

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 83.90  E-value: 1.93e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484   28 FGMWMGLEINLMSFIPMIINLESNKKSGEAAIKYFLIQAMASTVVIFSSLMFFLFSG----------------YSFSFTP 91
Cdd:pfam00361   5 LLMYLGWEAVLLPSYLLIGYWGKSPRSSEAGMKYFLLTLLGSSILLFGISLMYNYTGtlsfdelskaltgglnSSGLLLL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484   92 NIIITLALCMKLGMAPFHFWFPDVIEGLNWINSLILL-TWQKISPLVILSLFF--------YPYTLIAMALISAIMGAIS 162
Cdd:pfam00361  85 FLLILVGFLFKSAQVPFHTWLPDAYEGAPTPVSALLAaTLVKAGGYGLIRRSLlylpsspfIQQILLILAIISMLLGSLA 164

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 992329484  163 GINQTSMRKILAFSSISHLGWMTSIM----YFNSGLWLNYFIIYSFTSFIL 209
Cdd:pfam00361 165 ALVQTDIKRLLAYSSISHMGYMLIALgagtIYGIQAAIFHLLTHGLFSAGL 215
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
 51-184 8.23e-14

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 71.69  E-value: 8.23e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484  51 NKKSGEAAIKYFLIQAMASTVVIFSSLMFFLFSGySFSFT-----------PNIIITLALCM-------KLGMAPFHFWF 112
Cdd:COG1007  148 DRRSSEAALKYFLLGALSSGFLLYGISLLYGATG-SLNLAgiaaalaaggaNSPLLLLGLVLvlaglafKLSAVPFHMWT 226

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484 113 PDVIEGLNWINSLILLTWQKISPLVILSLFFYP----------YTLIAMALISAIMGAISGINQTSMRKILAFSSISHLG 182
Cdd:COG1007  227 PDVYEGAPTPVTAFLATAPKIAAFAALLRLLVEafpglaadwqLLLAVLAVLSMTVGNLAALAQTNVKRMLAYSSIAHAG 306


                 ..
gi 992329484 183 WM 184
Cdd:COG1007  307 YL 308
NDH_I_N TIGR01770
proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th ...
 29-217 1.12e-07

proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. The Enzyme Commission designation 1.6.5.3, for NADH dehydrogenase (ubiquinone), is applied broadly, perhaps unfortunately, even if the quinone is menaquinone (Thermus, Mycobacterium) or plastoquinone (chloroplast). For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone. [Energy metabolism, Electron transport]


Pssm-ID: 273795 [Multi-domain]  Cd Length: 468  Bit Score: 53.03  E-value: 1.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484   29 GMWMGLEINLMSFIPMIINLESNKKSGEAAIKYFLIQAMASTVVIFSSLMFFLFSG-----------------YSFSFTP 91
Cdd:TIGR01770 126 SIYLGLELQSLCFYVLAGLKRKSRFSTEAGLKYFILGAFSSGLLLFGISLIYGFTGslnfedlllflsngmlnISLLLLG 205

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484   92 NIIITLALCMKLGMAPFHFWFPDVIEGLNWINSLILLTWQKISPL-VILSLFFYPY---------TLIAMALISAIMGAI 161
Cdd:TIGR01770 206 IVLILVGLLFKLSAVPFHMWVPDVYEGAPTPVTAFFSIVPKIAIFaVFLRLFLYILfgfseawqiFLAIIAFLSMLIGNF 285

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484  162 SGINQTSMRKILAFSSISHLGW----MTSIMYFNSGLWLNYFIIYSFTSFILCFSFWMLN 217
Cdd:TIGR01770 286 GALAQKKVKRLLAYSSISHVGYiligLLAGTLEGIKAVLFYIFIYALMSLGAFGVLSLLR 345
 
Name Accession Description Interval E-value
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
 1-332 5.21e-69

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 218.54  E-value: 5.21e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484   1 MNLYFPPFMYSFFLFSGTLISISSSSLFGMWMGLEINLMSFIPMIINlESNKKSGEAAIKYFLIQAMASTVVIFSSLMFF 80
Cdd:MTH00160   1 MMMNSSKLLFLSTLIMGTLISISSNSWFGAWMGLEINLLSFIPLISN-KKNLMSSESSLKYFLIQALASIILLFSIILNM 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484  81 LFSgYSFSFTPNIIITLALCMKLGMAPFHFWFPDVIEGLNWINSLILLTWQKISPLVILSLFFYPYTLIAMALISAIMGA 160
Cdd:MTH00160  80 LNL-MLFNNISSMLINSSLLLKLGAAPFHFWFPEVMEGLSWINCFILMTWQKIAPLILLSYLINNNFIIIIIILSAIIGA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484 161 ISGINQTSMRKILAFSSISHLGWMTSIMYFNSGLWLNYFIIYSFTSFILCFSFWMLNLNYFSQLTLSQNMN--EKFMIFI 238
Cdd:MTH00160 159 IGGLNQTSLRKILAYSSINHLGWMLSSMMISENLWLIYFLIYSIISLSIILLFNKFNIFFLNQLFNSNNKSkkIKFLLFL 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484 239 NLLSLGGLPPLLGFLPKWIAM--MVISNNFPVLIILIMSSLITLYFYTRICFSTFTLYMQSMTWYQKSKTSKNFFMMSIL 316
Cdd:MTH00160 239 NLLSLGGLPPFLGFLPKWIIIqlLISNNMFFLLFILIMSSLITLYFYLRISYSSLMLNYNKNKWNLKKKKNKFSLILNFL 318

                        330
                 ....*....|....*.
gi 992329484 317 TFFSLIGIVPLSLINI 332
Cdd:MTH00160 319 SFISLFGLILSSLLFL 334
ND2 MTH00105
NADH dehydrogenase subunit 2; Provisional
 11-320 2.15e-49

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177167 [Multi-domain]  Cd Length: 347  Bit Score: 168.10  E-value: 2.15e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484  11 SFFLFSGTLISISSSSLFGMWMGLEINLMSFIPMIINlESNKKSGEAAIKYFLIQAMASTVVIFSSLMFFLFSG-----Y 85
Cdd:MTH00105  10 YLTLFLGTMITMISSHWLLAWIGLEMNMLAIIPILMK-KHNPRSTEAATKYFLTQATASMLLMMAIIINLMYSGqwtitK 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484  86 SFSFTPNIIITLALCMKLGMAPFHFWFPDVIEGLNWINSLILLTWQKISPLVIL---SLFFYPYTLIAMALISAIMGAIS 162
Cdd:MTH00105  89 LTNPTASTLMTIALAMKLGLAPFHFWVPEVTQGIPLSSGMILLTWQKLAPLSILyqiSPSINPNLLLTLAILSILIGGWG 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484 163 GINQTSMRKILAFSSISHLGWMTSIMYFNSGLWLNYFIIYSFTSFILcfsFWMLNLNYF-SQLTLSQNMNEKFMIFINLL 241
Cdd:MTH00105 169 GLNQTQLRKILAYSSIAHMGWMTAILPYNPTLTLLNLLIYIIMTLTM---FMLLMLNSStTTLSLSHTWNKTPLMTSLIL 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484 242 SLGGLP----PLLGFLPKWIAM--MVISNNFPVLIILIMSSLITLYFYTRICFSTfTLYM------QSMTWYQKSktSKN 309
Cdd:MTH00105 246 LTLLSLgglpPLTGFMPKWMIIqeLTKNNNIILPTLMAITALLNLYFYMRLIYST-SLTMfpstnnMKMKWQFEN--TKP 322

                        330
                 ....*....|.
gi 992329484 310 FFMMSILTFFS 320
Cdd:MTH00105 323 MTLLPTLIILS 333
ND2 MTH00112
NADH dehydrogenase subunit 2; Provisional
 1-321 1.20e-46

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214423 [Multi-domain]  Cd Length: 346  Bit Score: 161.14  E-value: 1.20e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484   1 MNLYFPPfMYSFFLFSGTLISISSSSLFGMWMGLEINLMSFIPMIINlESNKKSGEAAIKYFLIQAMASTVVIFSSLMFF 80
Cdd:MTH00112   1 MNPHAKL-IITTSLILGTIITISSNHWLMAWTGLEINTLAIIPLISK-PHHPRATEAATKYFLTQAAASALILFSSTTNA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484  81 LFSG-----YSFSFTPNIIITLALCMKLGMAPFHFWFPDVIEGLNWINSLILLTWQKISPLVIL---SLFFYPYTLIAMA 152
Cdd:MTH00112  79 WNTGqwditQLTNPTSCTLLTLALAMKLGLAPFHFWLPEVLQGSTTTTALILSTWQKLAPLTLLlmtSNSLNPTLLLTLA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484 153 LISAIMGAISGINQTSMRKILAFSSISHLGWMTSIMYFNSGLWLNYFIIYSFTSFILCFSFWMLNLNYFSQLTLSQNMNE 232
Cdd:MTH00112 159 ILSTLIGGWGGLNQTQLRKIMAFSSIAHLGWMIAIITYSPKLTLLTFYIYILMTTPMFLTLNTTSTKTLKDMMTSWTKSP 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484 233 KFMI--FINLLSLGGLPPLLGFLPKW--IAMMVISNNFPVLIILIMSSLITLYFYTRICF-STFTL----YMQSMTWYQK 303
Cdd:MTH00112 239 TLNTtlMLTLLSLAGLPPLTGFMPKWliLQELTKQNMTPTATIMAMLSLLSLFFYLRLTYiSTITLppntTNMMMKWRTK 318

                        330
                 ....*....|....*...
gi 992329484 304 SKTSKNFFMMSILTFFSL 321
Cdd:MTH00112 319 PKKNTLTATLTTLSTLLL 336
ND2 MTH00041
NADH dehydrogenase subunit 2; Validated
 8-330 6.41e-46

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 177116 [Multi-domain]  Cd Length: 349  Bit Score: 159.33  E-value: 6.41e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484   8 FMYSFFLFSGTLISISSSSLFGMWMGLEINLMSFIPmIINLESNKKSGEAAIKYFLIQAMASTVVIFSSLMFFLFSGYSF 87
Cdd:MTH00041   7 IFLITSIILGTIIVISSNHWFLIWLGLELNTLSIIP-ILSSNFSPRSVEATIKYFLVQAFSAAILLNGALIQAWLSGSWS 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484  88 SFTP-----NIIITLALCMKLGMAPFHFWFPDVIEGLNWINSLILLTWQKISPLVIL---SLFFYPYTLIAMALISAIMG 159
Cdd:MTH00041  86 INGPlntlsSIIITLALALKLGLAPCHFWFPDVLQGLPFLQGLIIATWQKIAPLILLisiSNLLNSNILILCGILSVLVG 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484 160 AISGINQTSMRKILAFSSISHLGWMTSIMYFNSGLWLNYFIIYSFTSFILCFSFWMLNLNYFSQLTLSQNMNEKFMIFIN 239
Cdd:MTH00041 166 GWGGLNQTQTRKILAFSSIAHLGWIIITSAYSPNASIIMFLIYIIINTSIFLIGNNFSLSTLSHLNKLSQLNPISAFLFI 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484 240 LLSLGGLPP--LLGFLPKWIAM--MVISNNFPVLIILIMSSLITLYFYTRICFSTFTLY-----MQSMTWYQKSKTSKNF 310
Cdd:MTH00041 246 LSILSLGGLppLTGFLNKFISLycLIQNNSILISIILIIGSLLSLFFYLRISFNTSLTLfpqhsISLFSWRNSGNITVYG 325

                        330       340
                 ....*....|....*....|
gi 992329484 311 FMMSILTFFSLIGIVPLSLI 330
Cdd:MTH00041 326 VILSILSSISILGLLLIPLF 345
ND2 MTH00070
NADH dehydrogenase subunit 2; Provisional
 7-321 3.26e-44

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177142 [Multi-domain]  Cd Length: 346  Bit Score: 154.69  E-value: 3.26e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484   7 PFMYSFFLFS---GTLISISSSSLFGMWMGLEINLMSFIPMIINLEsNKKSGEAAIKYFLIQAMASTVVIFSSLMFFLFS 83
Cdd:MTH00070   3 PYALSILLSSlalGTMITLSSNHWFLAWMGLEINTLAIIPLMTKTH-HPRATEAATKYFLTQASASALILFSSTINAWFT 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484  84 G-----YSFSFTPNIIITLALCMKLGMAPFHFWFPDVIEGLNWINSLILLTWQKISPLVIL---SLFFYPYTLIAMALIS 155
Cdd:MTH00070  82 GewtimNMQTPLPTIMLTIALMMKLGIAPFHFWLPEVLQGLDLTTGLILSTWQKLAPMALLiqiSHLLNSNLLIIMGLLS 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484 156 AIMGAISGINQTSMRKILAFSSISHLGWMTSIMYFNSGLWLNYFIIYSFTSFILCFSFWMLNLNYFSQLTLS--QNMNEK 233
Cdd:MTH00070 162 TLIGGWGGLNQTQLRKIMAYSSIAHLGWMIIILTFSPHLTLLNLLIYLIMTSSMFLMLMNLNSTNINKLSSSwsKNPTLT 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484 234 FMIFINLLSLGGLPPLLGFLPKW-IAMMVISNNFPVL-IILIMSSLITLYFYTRICFSTF-----TLYMQSMTWYQKSKT 306
Cdd:MTH00070 242 SMMMLTLLSLGGLPPTTGFIPKWlILQELTKQNLTTLaTLMALSALLSLFFYLRLSYAMSlttspNTSNSKLYWRFKNKT 321

                        330
                 ....*....|....*
gi 992329484 307 SKNFFMMSILTFFSL 321
Cdd:MTH00070 322 NNLLSLTIILSLMLL 336
ND2 MTH00200
NADH dehydrogenase subunit 2; Provisional
 1-322 3.32e-42

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177246 [Multi-domain]  Cd Length: 347  Bit Score: 149.35  E-value: 3.32e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484   1 MNLYFPPFMySFFLFSGTLISISSSSLFGMWMGLEINLMSFIPMIINLESNKKSgEAAIKYFLIQAMASTVVIFSSLMFF 80
Cdd:MTH00200   1 MSPLILPLF-ILSLGLGTLLTFSSSHWFLIWLGLEINTLAIIPLLIKQHHPRKV-EATTKYFIIQATASALLLFGGLLNA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484  81 LFSG-----YSFSFTPNIIITLALCMKLGMAPFHFWFPDVIEGLNWINSLILLTWQKISPLVILSLFFY---PYTLIAMA 152
Cdd:MTH00200  79 WTSGqwgisEMLGPLSETLILLALALKLGLAPGHFWVPDVLQGLSLQTGLILSTWQKLAPFALLIQLAPalnSNILLLLG 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484 153 LISAIMGAISGINQTSMRKILAFSSISHLGWMTSIMYFNSGLWLNYFIIYSFTSFILCFSFWMLNLNYFSQLTLSQNMNE 232
Cdd:MTH00200 159 LLSVLVGGWGGLNQTQLRKILAYSSIAHLGWLLSGLVYSPNLALLYLLLYVIITLTVFLLLNLLNSTKINSLSSSKTKNP 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484 233 KFMIFINLLSLGGLPP--LLGFLPKWIAMMVISNN--FPVLIILIMSSLITLYFYTRICF---STFTLYMQSMTWYQKSK 305
Cdd:MTH00200 239 ILSMLLGLTLLSLGGLppLTGFFPKWLILQELSKQglFIYATILLLGSLLSLFFYLRLSYltlLTLSPNQINMMSSWRTK 318

                        330
                 ....*....|....*..
gi 992329484 306 TSKNFFMMSILTFFSLI 322
Cdd:MTH00200 319 SNSNLLVGLLLLLSILG 335
ND2 MTH00135
NADH dehydrogenase subunit 2; Provisional
 7-219 5.15e-41

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177193 [Multi-domain]  Cd Length: 347  Bit Score: 146.10  E-value: 5.15e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484   7 PFMYSFFLFS---GTLISISSSSLFGMWMGLEINLMSFIPMIINlESNKKSGEAAIKYFLIQAMASTVVIFSSLMFFLFS 83
Cdd:MTH00135   3 PYVLTILLFSlglGTTLTFASSHWLLAWMGLEINTLAIIPLMAQ-HHHPRAVEATTKYFLTQATAAAMILFASTTNAWLT 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484  84 G-----YSFSFTPNIIITLALCMKLGMAPFHFWFPDVIEGLNWINSLILLTWQKISPLVILS--LFFYPYTLIAMALISA 156
Cdd:MTH00135  82 GqwdiqQMSHPLPTTMITLALALKIGLAPLHFWLPEVLQGLDLTTGLILSTWQKLAPFALILqiAPTNPTLLITLGLTST 161

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 992329484 157 IMGAISGINQTSMRKILAFSSISHLGWMTSIMYFNSGLWLNYFIIYsftsFILCFS-FWMLNLN 219
Cdd:MTH00135 162 LVGGWGGLNQTQLRKILAYSSIAHLGWMILVLQFSPSLTLLALLTY----IIMTSSaFLTFKLN 221
ND2 MTH00144
NADH dehydrogenase subunit 2; Provisional
 8-332 4.17e-40

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214432 [Multi-domain]  Cd Length: 328  Bit Score: 143.49  E-value: 4.17e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484   8 FMYSFFLFSGTLISISSSSLFGMWMGLEINLMSFIPMIiNLESNKKSGEAAIKYFLIQAMASTVVIFSSLMFFLFSGYSF 87
Cdd:MTH00144   7 LLFLFLMVMGTLLSLSSSHWLGVWVGLEINLIGFLPLL-VYKKKSSESESVVKYFIIQSLGSSLLIFGSLIMYNLSFSWF 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484  88 SFtpnIIITLALCMKLGMAPFHFWFPDVIEGLNWINSLILLTWQKISPLVILSLFFY----PYTLIAMALISAIMGAISG 163
Cdd:MTH00144  86 SM---SLLLLGLCLKLGLFPFHFWVPSVMAGLSWLSCFLLLTWQKVAPLFLLSNFLDlywlAYLLCVISVLSALVGSIGG 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484 164 INQTSMRKILAFSSISHLGWMTSIMYFNSGLWLNYFIIYSFTSFILCFSFWMLNLNYFSQLT-LSQNMNEKFMIFINLLS 242
Cdd:MTH00144 163 LNQTQVRALLAYSSISHTGWMLVAILHGSWLMWMYFLIYIVSSGFLFFSLWSGDSGSMKDLGsLKPSYKTGLSIISLLLS 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484 243 LGGLPPLLGFLPKWIAMMVISNNFPVLII--LIMSSLITLYFYTRICFSTFtlymqsMTWYQKSKTSKNFFMMSILTFFS 320
Cdd:MTH00144 243 LGGLPPFLGFCSKLLVLISSMESSPLLLIllLLLGSLISLFFYLSVFFSSF------LSSSKSKKSNSSKVLNSSIISLN 316

                        330
                 ....*....|..
gi 992329484 321 LIGIVPLSLINI 332
Cdd:MTH00144 317 LLGGLLFLLLYL 328
ND2 MTH00011
NADH dehydrogenase subunit 2; Validated
 30-317 7.00e-34

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 164587 [Multi-domain]  Cd Length: 330  Bit Score: 126.82  E-value: 7.00e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484  30 MWMGLEINLMSFIPMIINLESNKKSgEAAIKYFLIQAMASTVVIFSSLMFFLFSGYSFSFTPnIIITLALCMKLGMAPFH 109
Cdd:MTH00011  31 LWMGMELNLLSFVPLMTSSKMNQES-EAAVKYFLAQALGSGLLLLGMTMMWSFPSLLKNITA-LMLLVSLMLKLGMAPCH 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484 110 FWFPDVIEGLNWINSLILLTWQKISPLVILsLFFYPYT----LIAMALISAIMGAISGINQTSMRKILAFSSISHLGWMT 185
Cdd:MTH00011 109 FWFPSVMSSISWTLCLILSTWQKIAPLSIL-FFFTSHNilpmMTSMAAMSALAGGLGGMNQTQLRPLLAYSSIGHMGWMT 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484 186 SIMYFNSGLWLNYFIIYSFTSFILCFSFWMLNLNYFSQLTLSQNMNE--KFMIFINLLSLGGLPPLLGFLPKWIAMMVIS 263
Cdd:MTH00011 188 MISVFSPSMAILYFMTYIIITTPLMLLFAYLNAFSTKFNSKISSMSQttSMSLFIMLLSLGGLPPFTGFMPKLMAIETLT 267

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 992329484 264 NN--FPVLIILIMSSLITLYFYTRICFSTFTLYMQSMTWYQKSKTSKNFFMMSILT 317
Cdd:MTH00011 268 SNsmILILLVLIVGSLMNLFYYLNLIFNFMYLSPTFSSLKSAPYEPKTKILISMCT 323
ND2 MTH00197
NADH dehydrogenase subunit 2; Provisional
 8-325 1.77e-27

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177244 [Multi-domain]  Cd Length: 323  Bit Score: 109.38  E-value: 1.77e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484   8 FMYSFFLFSGTLISISSSSLFGMWMGLEINLMSFIPMIINLeSNKKSGEAAIKYFLIQAMASTVVIFSSLmfFLFSGYSF 87
Cdd:MTH00197   1 FLFLFIIFGGVLFSLSSSNWFLVWIGMELNLIGFIPLLSQN-KSITENEGAMKYFLFQEFGSALLLMGGS--LSFSNLYL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484  88 SFTPNIIITLALCMKLGMAPFHFWFPDVIEGLNWINSLILLTWQKISPLVILSLFFYPYTLIAM-ALISAIMGAISGINQ 166
Cdd:MTH00197  78 SLLSVVLVILGLLLKLGAFPFHFWVPSVMESLSWFNCFLLATWQKLAPLLILAFNSSSFMGLLIcSVLSSLIGGIGGMNQ 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484 167 TSMRKILAFSSISHLGWMTSIMYFNSGLWLNYFIIYSFTSFILCFSFWMLNLNYFSQLTLSQNMNEKFMIFINLLSLGGL 246
Cdd:MTH00197 158 SNIRQLLAYSSIGHTGWMLMSLVYSPSIFMLYYLIYFVIMFMLFLFLSKNNLSSLNQQYSNPESMSSNLVFLGLSFLSLG 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484 247 PP--LLGFLPKWIAM--MVISNNFPVLIILIMSSLITLYFYTRICFSTFtlyMQSMTWYQKSKTSKNFFMMSILTFFSLI 322
Cdd:MTH00197 238 GLppLSGFFLKWLILtsLLSSNISLITFMLILSTCFSLYYYLSLAYKSL---ILSNWMINFLMKINLLYSGLFILLMMML 314


                 ...
gi 992329484 323 GIV 325
Cdd:MTH00197 315 PLL 317
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 28-209 1.93e-18

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 83.90  E-value: 1.93e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484   28 FGMWMGLEINLMSFIPMIINLESNKKSGEAAIKYFLIQAMASTVVIFSSLMFFLFSG----------------YSFSFTP 91
Cdd:pfam00361   5 LLMYLGWEAVLLPSYLLIGYWGKSPRSSEAGMKYFLLTLLGSSILLFGISLMYNYTGtlsfdelskaltgglnSSGLLLL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484   92 NIIITLALCMKLGMAPFHFWFPDVIEGLNWINSLILL-TWQKISPLVILSLFF--------YPYTLIAMALISAIMGAIS 162
Cdd:pfam00361  85 FLLILVGFLFKSAQVPFHTWLPDAYEGAPTPVSALLAaTLVKAGGYGLIRRSLlylpsspfIQQILLILAIISMLLGSLA 164

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 992329484  163 GINQTSMRKILAFSSISHLGWMTSIM----YFNSGLWLNYFIIYSFTSFIL 209
Cdd:pfam00361 165 ALVQTDIKRLLAYSSISHMGYMLIALgagtIYGIQAAIFHLLTHGLFSAGL 215
PRK05777 PRK05777
NADH-quinone oxidoreductase subunit NuoN;
51-206 3.11e-14

NADH-quinone oxidoreductase subunit NuoN;


Pssm-ID: 235603 [Multi-domain]  Cd Length: 476  Bit Score: 72.93  E-value: 3.11e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484  51 NKKSGEAAIKYFLIQAMASTVVIFSSLMFFLFSGySFSFT-----------PNIIITLA-------LCMKLGMAPFHFWF 112
Cdd:PRK05777 149 RRRSLEAAIKYFVLGALASGFLLYGMSLLYGATG-SLSFAgiakaladgsgNSLLLLFGlvfllvgLAFKLSAVPFHMWT 227

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484 113 PDVIEGLNWINSLILLTWQKISPLVILSLFFY----------PYTLIAMALISAIMGAISGINQTSMRKILAFSSISHLG 182
Cdd:PRK05777 228 PDVYEGAPTPVTAFLATAPKIAAFAVLLRLLVvafgglsedwQQVLAIIAIASMLVGNLAALSQTNIKRLLAYSSIAHAG 307

                        170       180       190
                 ....*....|....*....|....*....|.
gi 992329484 183 WM-------TSIMYfnSGLWLnYFIIYSFTS 206
Cdd:PRK05777 308 YLlvglaagTAEGY--SAVLF-YLLAYLFMT 335
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
 51-184 8.23e-14

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 71.69  E-value: 8.23e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484  51 NKKSGEAAIKYFLIQAMASTVVIFSSLMFFLFSGySFSFT-----------PNIIITLALCM-------KLGMAPFHFWF 112
Cdd:COG1007  148 DRRSSEAALKYFLLGALSSGFLLYGISLLYGATG-SLNLAgiaaalaaggaNSPLLLLGLVLvlaglafKLSAVPFHMWT 226

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484 113 PDVIEGLNWINSLILLTWQKISPLVILSLFFYP----------YTLIAMALISAIMGAISGINQTSMRKILAFSSISHLG 182
Cdd:COG1007  227 PDVYEGAPTPVTAFLATAPKIAAFAALLRLLVEafpglaadwqLLLAVLAVLSMTVGNLAALAQTNVKRMLAYSSIAHAG 306


                 ..
gi 992329484 183 WM 184
Cdd:COG1007  307 YL 308
ND2 MTH00199
NADH dehydrogenase subunit 2; Provisional
 54-182 1.56e-13

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177245 [Multi-domain]  Cd Length: 460  Bit Score: 70.82  E-value: 1.56e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484  54 SGEAAIKYFLIQAMASTVVIFSSLMFFLFSGYS---------FSFTPNIIITLALCMKLGMAPFHFWFPDVIEGLNWINS 124
Cdd:MTH00199 146 STEAGLKYFVLGAVSSGLFLFGCALLYGLTGETsiqginsilTGDVGKILITISLLFKLSAAPFHMWAPDVYEGAPTITT 225

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 992329484 125 LILLTWQKISPLVIL-SLFFYPYTLIAMALISAIMGAISGINQTSMRKILAFSSISHLG 182
Cdd:MTH00199 226 ALLATVPKIGVFSILvQIGPVTNVVLICAVLSIIYGAIGALNQTKIKRLLAYSGIGHMG 284
ND2 MTH00196
NADH dehydrogenase subunit 2; Provisional
 30-206 6.02e-12

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214453 [Multi-domain]  Cd Length: 365  Bit Score: 65.82  E-value: 6.02e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484  30 MWMGLEINLMSFIPMIINLESNKKSGEAAIKYFLIQAMASTVVIFSSLMFFLFSG------YSFSFTP------------ 91
Cdd:MTH00196  18 VYLAIELQTLSLFILIAQNRGSGYSAEAGLKYFVLGALSSGLFLFGCALLCGTTGglhlsyINLVLNSgqsfssvsvpig 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484  92 NIIITLALCMKLGMAPFHFWFPDVIEGLNWINSLILLTWQKISPLVILSLFFYPYTLIAMA-LISAIMGAISGINQTSMR 170
Cdd:MTH00196  98 YLLIIVALLFKLSVAPFHMWAPDVYEGAPTKTTALLAIVPKLGIFSILVSIGLNVNILLIGgLFSLFVGAIGALNQTKIK 177

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 992329484 171 KILAFSSISHLG---WMTSIMYFNS-GLWLNYFIIYSFTS 206
Cdd:MTH00196 178 RLLAYSGIGHMGfvlWGIEIGSFESiQASLVYLFIYIIMS 217
ND2 MTH00198
NADH dehydrogenase subunit 2; Provisional
 56-184 1.14e-11

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214454 [Multi-domain]  Cd Length: 607  Bit Score: 65.65  E-value: 1.14e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484  56 EAAIKYFLIQAMASTVVIFSSLMFFLFSGYSFSF---------TPNI----------IITLALCMKLGMAPFHFWFPDVI 116
Cdd:MTH00198 247 ESGLKYWILGAMSSGFYLFGCALYFGFTGNEGMLgtilsatleTTNIelrqgslgylFITVAILFKLAAAPFHMWTPDVY 326

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 992329484 117 EGLNWINSLILLTWQKISPLVIL-SLFFYPYTLIAMALISAIMGAISGINQTSMRKILAFSSISHLGWM 184
Cdd:MTH00198 327 EGAPTPTTALIAIIPKFTVYILLtSLVITSKLLLSVAIISLVVGAFGALNQTRIKRLLAYSGIGHIGFI 395
PRK02504 PRK02504
NAD(P)H-quinone oxidoreductase subunit N;
51-182 7.88e-08

NAD(P)H-quinone oxidoreductase subunit N;


Pssm-ID: 235044 [Multi-domain]  Cd Length: 513  Bit Score: 53.52  E-value: 7.88e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484  51 NKKSGEAAIKYFLIQAMASTVVIFSSLMFFLFSGYSFSFT---------PNIIITLAL-------CMKLGMAPFHFWFPD 114
Cdd:PRK02504 156 DPRSNEAALKYLLIGAASSAIFLYGSSLLYGLSGGSTQLSaialalitsPSLGLALALvfviagiAFKISAVPFHQWTPD 235

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 992329484 115 VIEGLNWINSLILLTWQKIS----PLVILSLFFYPYT------LIAMALISAIMGAISGINQTSMRKILAFSSISHLG 182
Cdd:PRK02504 236 VYEGSPTPVVAFLSVGSKAAgfalAIRLLVTAFPSFDeqwkllFTALAILSMVLGNVVALAQTSMKRMLAYSSIGQAG 313
NDH_I_N TIGR01770
proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th ...
 29-217 1.12e-07

proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. The Enzyme Commission designation 1.6.5.3, for NADH dehydrogenase (ubiquinone), is applied broadly, perhaps unfortunately, even if the quinone is menaquinone (Thermus, Mycobacterium) or plastoquinone (chloroplast). For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone. [Energy metabolism, Electron transport]


Pssm-ID: 273795 [Multi-domain]  Cd Length: 468  Bit Score: 53.03  E-value: 1.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484   29 GMWMGLEINLMSFIPMIINLESNKKSGEAAIKYFLIQAMASTVVIFSSLMFFLFSG-----------------YSFSFTP 91
Cdd:TIGR01770 126 SIYLGLELQSLCFYVLAGLKRKSRFSTEAGLKYFILGAFSSGLLLFGISLIYGFTGslnfedlllflsngmlnISLLLLG 205

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484   92 NIIITLALCMKLGMAPFHFWFPDVIEGLNWINSLILLTWQKISPL-VILSLFFYPY---------TLIAMALISAIMGAI 161
Cdd:TIGR01770 206 IVLILVGLLFKLSAVPFHMWVPDVYEGAPTPVTAFFSIVPKIAIFaVFLRLFLYILfgfseawqiFLAIIAFLSMLIGNF 285

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484  162 SGINQTSMRKILAFSSISHLGW----MTSIMYFNSGLWLNYFIIYSFTSFILCFSFWMLN 217
Cdd:TIGR01770 286 GALAQKKVKRLLAYSSISHVGYiligLLAGTLEGIKAVLFYIFIYALMSLGAFGVLSLLR 345
PRK12650 PRK12650
DUF4040 family protein;
93-184 1.66e-07

DUF4040 family protein;


Pssm-ID: 237158 [Multi-domain]  Cd Length: 962  Bit Score: 52.74  E-value: 1.66e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484  93 IIITLALCMKLGMAPFHFWFPDVIEGLNWInSLILLTWQKISPLVILSLFFYP---------YTLIAMALISAIMGAISG 163
Cdd:PRK12650 212 VLIAVAAFTKSAQFPFHFWLPEAMAAITPV-SAFLHAAAVVKAGIYLLLRFSPvfhdvavwnWLLIIVGMITALMGAVFA 290

                         90       100
                 ....*....|....*....|.
gi 992329484 164 INQTSMRKILAFSSISHLGWM 184
Cdd:PRK12650 291 VQKTDLKKLTAYSTVSQLGWI 311
HyfB COG0651
Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy ...
 28-184 6.35e-07

Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy production and conversion, Inorganic ion transport and metabolism];


Pssm-ID: 440416 [Multi-domain]  Cd Length: 430  Bit Score: 50.53  E-value: 6.35e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484  28 FGMWMGLEINLMSFIPMIInLESNKKSGEAAIKYFLIQAMASTVVIFSSLMFFLFSGySFSFTPN--------------- 92
Cdd:COG0651  130 FNLFVFFEVMLLASYGLVA-LGGTKEALRAGLKYLILNLVGSALFLLGVGLLYGATG-TLNMADLaarlaeldpglllaa 207

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484  93 -IIITLALCMKLGMAPFHFWFPD-----------VIEGlnwinsliLLTwqKISPLVILSLFFY----------PYTLIA 150
Cdd:COG0651  208 fALLLVGFGIKAALFPLHFWLPDaypaapspvsaLLSG--------LLT--KVGVYAILRVLTLlfgadpalflGTLLLV 277

                        170       180       190
                 ....*....|....*....|....*....|....
gi 992329484 151 MALISAIMGAISGINQTSMRKILAFSSISHLGWM 184
Cdd:COG0651  278 LGLLTMLVGALGALAQRDLKRLLAYSSVSQIGYI 311
NDH_I_M TIGR01972
proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th ...
 39-185 2.15e-06

proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th (based on E. coli) structural gene, M, of bacterial NADH dehydrogenase I, as well as chain 4 of the corresponding mitochondrial complex I and of the chloroplast NAD(P)H dehydrogenase complex. [Energy metabolism, Electron transport]


Pssm-ID: 273903 [Multi-domain]  Cd Length: 481  Bit Score: 49.17  E-value: 2.15e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484   39 MSFIPM--IINLESNKKSGEAAIKYFLIQAMASTVVIFSSLMFFLFSGYSFSFTPN--------------IIITLALCMK 102
Cdd:TIGR01972 137 AMLIPMylLIGVWGGPNRIYAAMKFFLYTLAGSLLMLLAILGLYFLGGGTFDLLELlnlplpfgvqtwlfLAFFIAFAVK 216

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484  103 LGMAPFHFWFPDVIEGLNWINSLILL-TWQKISPLVIL----------SLFFYPYtLIAMALISAIMGAISGINQTSMRK 171
Cdd:TIGR01972 217 VPLFPLHTWLPDAHVEAPTAGSVILAgVLLKMGTYGFLrfnlplfpdaSLYFAPV-LAALGVIAIIYGALIALAQTDIKR 295

                         170
                  ....*....|....
gi 992329484  172 ILAFSSISHLGWMT 185
Cdd:TIGR01972 296 LIAYSSISHMGFVL 309
ndhB CHL00049
NADH dehydrogenase subunit 2
 53-185 2.36e-06

NADH dehydrogenase subunit 2


Pssm-ID: 176990 [Multi-domain]  Cd Length: 494  Bit Score: 48.85  E-value: 2.36e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484  53 KSGEAAIKYFLIQAMASTVV-------------------IFSSLMFFLFSGYSFSFTPNIIITLALCMKLGMAPFHFWFP 113
Cdd:CHL00049 159 RSNEATMKYLLMGGASSSILvygfswlyglsggeielqeIVNGLINTQMYNSPGISIALIFITVGIGFKLSLAPFHQWTP 238

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484 114 DVIEGLNWINSLILLTWQKISPLV----ILSLFFYPYT------LIAMALISAIMGAISGINQTSMRKILAFSSISHLGW 183
Cdd:CHL00049 239 DVYEGSPTPVVAFLSVTSKVAASAlatrIFDIPFYFSSnewhllLEILAILSMILGNLIAITQTSMKRMLAYSSIGQIGY 318


                 ..
gi 992329484 184 MT 185
Cdd:CHL00049 319 VI 320
NuoL COG1009
Membrane H+-translocase/NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ ...
 107-185 5.56e-05

Membrane H+-translocase/NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit [Energy production and conversion]; Membrane H+-translocase/NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440633 [Multi-domain]  Cd Length: 608  Bit Score: 44.76  E-value: 5.56e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484 107 PFHFWFPDVIEGLNWINSLI-----------LLTwqKISPLVILSLFFYpYTLIAMALISAIMGAISGINQTSMRKILAF 175
Cdd:COG1009  229 PLHFWLPDAMEGPTPVSALLhaatmvkagvyLLA--RLSPLFALSPVWL-TVVAIIGAITALFAALIALAQTDIKRVLAY 305

                         90
                 ....*....|
gi 992329484 176 SSISHLGWMT 185
Cdd:COG1009  306 STVSQLGYMF 315
PRK06473 PRK06473
NADH-quinone oxidoreductase subunit M;
53-184 7.10e-05

NADH-quinone oxidoreductase subunit M;


Pssm-ID: 235810 [Multi-domain]  Cd Length: 500  Bit Score: 44.31  E-value: 7.10e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484  53 KSGEAAIKYFLIQAMASTVVIFSSL-MFFLFSGYSFSFTPN--------------IIITLALCMKLGMAPFHFWFPDV-I 116
Cdd:PRK06473 154 RRGYAATKFLLYTAISGILILVSFLgLVWLSGASSFDYEPLrshtlplstqllllAPILVGFGIKIPLVPFHTWLPDAhV 233

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 992329484 117 EGLNWINSLILLTWQKISPLVIL----SLFFYPYTLIA-----MALISAIMGAISGINQTSMRKILAFSSISHLGWM 184
Cdd:PRK06473 234 EASTPVSVLLAGVLLKLGTYGLLrfgvGLFPEAWVYLApwlatWAVVSVLYGASCAIAQKDMKKMVAYSSIGHMGYI 310
NuoM COG1008
NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; NADH: ...
 42-185 1.85e-04

NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 4 (chain M) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440632 [Multi-domain]  Cd Length: 488  Bit Score: 43.15  E-value: 1.85e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484  42 IPM--IINLESNKKSGEAAIKYFLIQAMAStVVIFSSLMFFLFSGYSFSF----------TPN------IIITLALCMKL 103
Cdd:COG1008  145 IPMyfLIGIWGGERRIYAAIKFFLYTLAGS-LLMLVAILALYFLAGALTFdiaelaaaplPLTaqlllfLAFFIAFAVKV 223

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484 104 GMAPFHFWFPDVIE----GLNWINSLILLtwqKISP--LVILSLFFYP-------YTLIAMALISAIMGAISGINQTSMR 170
Cdd:COG1008  224 PMFPFHTWLPDAHVeaptAGSVLLAGVLL---KMGGygLLRFALPLFPeasayfaPLLAALGVIGIIYGALVALAQTDLK 300

                        170
                 ....*....|....*
gi 992329484 171 KILAFSSISHLGWMT 185
Cdd:COG1008  301 RLIAYSSVSHMGFVL 315
PRK07363 PRK07363
NADH-quinone oxidoreductase subunit M;
35-184 2.16e-04

NADH-quinone oxidoreductase subunit M;


Pssm-ID: 180945 [Multi-domain]  Cd Length: 501  Bit Score: 42.78  E-value: 2.16e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484  35 EINLMSFIPMIiNLESNKKSGEAAIKYFLIQAMASTVVIFSSL-MFFLFSGYSFSFTPN--------------IIITLAL 99
Cdd:PRK07363 137 ELELIPFYLLI-AIWGGEKRGYASIKFLIYTAVSGLLVLAAFLgIVWLSGSTSFDYDAIstqnlslntqlillTGLLLGF 215

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484 100 CMKLGMAPFHFWFPDV-IEGLNWINSLILLTWQKISPLVI----LSLFFYPYTLIAMAL-----ISAIMGAISGINQTSM 169
Cdd:PRK07363 216 GIKIPLVPLHTWLPDAyTEASPAVAILLGGVLAKLGTYGLlrfgLQLFPQTWSLVAPGLaiigtISVIYGALSAIAQKDI 295

                        170
                 ....*....|....*
gi 992329484 170 RKILAFSSISHLGWM 184
Cdd:PRK07363 296 KRMVAYSSIGHMGYI 310
PRK08376 PRK08376
putative monovalent cation/H+ antiporter subunit D; Reviewed
 56-184 2.36e-04

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 236252 [Multi-domain]  Cd Length: 521  Bit Score: 42.78  E-value: 2.36e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484  56 EAAIKYFLIQAMASTVVIFSSLMFF-----LFSGY---SFSFTPNII-------ITLALCMKLGMAPFHFWFPDVIEGLN 120
Cdd:PRK08376 172 EAGIKYMFVGSLASSMVLLGIALLYgqygtLNMAYlavKMSENPTVVakialalFIAGLAMKSGAVPVHMWLPDAYPAAP 251

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 992329484 121 WINSLILLTWQKISPLVI-----------LSLFFYPYTLIAMALISAIMGAISGINQTSMRKILAFSSISHLGWM 184
Cdd:PRK08376 252 SSISAMLLVIKQAGLYALarvlfsiygpaINLATVGWVIIILGCLTMFVGVAMAVVQKDVKRLLAYHSVSQIGYM 326
PRK08375 PRK08375
putative monovalent cation/H+ antiporter subunit D; Reviewed
 89-184 7.89e-04

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 236251 [Multi-domain]  Cd Length: 487  Bit Score: 41.02  E-value: 7.89e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484  89 FTPNIIITLALCMKLGMAPFHFWFPDVIEGLNWINSLIL-LTWQKISPLVILSLFFYPYT------------LIAMALIS 155
Cdd:PRK08375 202 VTAFGFVLLALALKAAVFPLHTWLPRAYPAAPPVVTALLsGLVTKVAVYALIRIYFTVFGgdfrfalglgwlLAVLALLS 281

                         90       100
                 ....*....|....*....|....*....
gi 992329484 156 AIMGAISGINQTSMRKILAFSSISHLGWM 184
Cdd:PRK08375 282 MLVGSLAALGQDDVKRVLAYSTVSQMGYI 310
PRK07376 PRK07376
NADH-quinone oxidoreductase subunit L;
107-188 2.12e-03

NADH-quinone oxidoreductase subunit L;


Pssm-ID: 236005 [Multi-domain]  Cd Length: 673  Bit Score: 40.01  E-value: 2.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484 107 PFHFWFPDVIEGLNWINSLI---------LLTWQKISPLviLSLFFYPYTLIA-MALISAIMGAISGINQTSMRKILAFS 176
Cdd:PRK07376 245 PLHVWLPDAMEGPTPISALIhaatmvaagVFLVARMYPV--FEQFPAVMTVIAwTGAITAFLGASIALTQNDIKKGLAYS 322

                         90
                 ....*....|..
gi 992329484 177 SISHLGWMTSIM 188
Cdd:PRK07376 323 TISQLGYMVMAM 334
PRK12646 PRK12646
DUF4040 family protein;
30-194 3.34e-03

DUF4040 family protein;


Pssm-ID: 183646 [Multi-domain]  Cd Length: 800  Bit Score: 39.35  E-value: 3.34e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484  30 MWMGLEINLMSFIPMIINLESNKKSGEAAIKYFLIQAMASTVVIFSSLMFFLFSGY---------------SFSFTPNII 94
Cdd:PRK12646 135 MYVFWELTSVSSFLLISYWYNNGDSQFGAIQSFMITVFGGLALLVGFIMLYIMTGTnniteilgqadhiknHGLFIPMIF 214

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484  95 -ITLALCMKLGMAPFHFWFPDVIEGLNWINSLI---------LLTWQKISPLVILSlFFYPYTLIAMALISAIMGAISGI 164
Cdd:PRK12646 215 mFLLGAFTKSAQFPFHIWLPRAMAAPTPVSAYLhsatmvkagIFLLFRFTPLLGLS-NMYIYIVTFVGLITMLFGSITAL 293

                        170       180       190
                 ....*....|....*....|....*....|
gi 992329484 165 NQTSMRKILAFSSISHLGWMTSIMYFNSGL 194
Cdd:PRK12646 294 KQWDLKGILAYSTISQLGMIMAMVGIGGGY 323
PRK12667 PRK12667
putative monovalent cation/H+ antiporter subunit D; Reviewed
 28-182 3.42e-03

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 237167 [Multi-domain]  Cd Length: 520  Bit Score: 39.18  E-value: 3.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484  28 FGMWMGLEINLMSFIPMIINLESNKKSGEAAIKYFLIQAMASTVVIF-----------------SSLMFFLFSGYSFSFT 90
Cdd:PRK12667 136 FNLFVMLEVLSISAYGLVAYYRDRGDAVEAAIKYALIGAVGTTLYFLalaflyatfgtlnmadlSAKIRGLSFPLTGGLA 215

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992329484  91 PNIIITLALCM---------KLGMAPFHFWFPD---------------VIEGLNWINSL-ILLTWQKISPLVILSLFFYP 145
Cdd:PRK12667 216 GNPPLALGVALalalwaftiKAAIFPNHFWLPDahpaapspvsamlsgLVVNVGAYAIIrFLYTIFGISPSLIDFRAALS 295

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 992329484 146 YTLIAMALISAIMGAISGINQTSMRKILAFSSISHLG 182
Cdd:PRK12667 296 PILIILGAVSAIIGALMMVVQKDVKRLLAYSTISHMG 332
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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