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Conserved domains on  [gi|1381394739|ref|YP_009480267|]
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NADH dehydrogenase subunit 2 (mitochondrion) [Navis striatus]

Protein Classification

NADH dehydrogenase subunit 2( domain architecture ID 11475933)

NADH dehydrogenase subunit 2 is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
 1-316 3.94e-60

NADH dehydrogenase subunit 2; Provisional


:

Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 195.04  E-value: 3.94e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739   1 MTTIILFWILILTVFMAMSTSSLFSLWICMEINMMMFM-PMMNSKNILSSNSMILYFIIQSLASSIFILSFLINFLMM-- 77
Cdd:MTH00160    5 SSKLLFLSTLIMGTLISISSNSWFGAWMGLEINLLSFIpLISNKKNLMSSESSLKYFLIQALASIILLFSIILNMLNLml 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739  78 VNYITMMLITSAILIKLGAAPFHIWFPQVSEGLKFMPFSFLILNQKLIPLYILS-FLNNSVMVMSIIFSSLIGSFGGWNQ 156
Cdd:MTH00160   85 FNNISSMLINSSLLLKLGAAPFHFWFPEVMEGLSWINCFILMTWQKIAPLILLSyLINNNFIIIIIILSAIIGAIGGLNQ 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739 157 NSIRKIIAFSTIAHLSWMISIILCYNNWWTMYFFMYSFIIITLIFFLFKTEMSYINQ--TNFFLDFSKKISLITILMSLG 234
Cdd:MTH00160  165 TSLRKILAYSSINHLGWMLSSMMISENLWLIYFLIYSIISLSIILLFNKFNIFFLNQlfNSNNKSKKIKFLLFLNLLSLG 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739 235 GMPPFLGFLMKWMSIKIISMSNPIFL-FFLIPSSLLNLFFYSRIMYPYFFKKMEINKMAQKMKKSGTMTAMNFLLMFLMI 313
Cdd:MTH00160  245 GLPPFLGFLPKWIIIQLLISNNMFFLlFILIMSSLITLYFYLRISYSSLMLNYNKNKWNLKKKKNKFSLILNFLSFISLF 324


                  ...
gi 1381394739 314 PMI 316
Cdd:MTH00160  325 GLI 327
 
Name Accession Description Interval E-value
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
 1-316 3.94e-60

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 195.04  E-value: 3.94e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739   1 MTTIILFWILILTVFMAMSTSSLFSLWICMEINMMMFM-PMMNSKNILSSNSMILYFIIQSLASSIFILSFLINFLMM-- 77
Cdd:MTH00160    5 SSKLLFLSTLIMGTLISISSNSWFGAWMGLEINLLSFIpLISNKKNLMSSESSLKYFLIQALASIILLFSIILNMLNLml 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739  78 VNYITMMLITSAILIKLGAAPFHIWFPQVSEGLKFMPFSFLILNQKLIPLYILS-FLNNSVMVMSIIFSSLIGSFGGWNQ 156
Cdd:MTH00160   85 FNNISSMLINSSLLLKLGAAPFHFWFPEVMEGLSWINCFILMTWQKIAPLILLSyLINNNFIIIIIILSAIIGAIGGLNQ 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739 157 NSIRKIIAFSTIAHLSWMISIILCYNNWWTMYFFMYSFIIITLIFFLFKTEMSYINQ--TNFFLDFSKKISLITILMSLG 234
Cdd:MTH00160  165 TSLRKILAYSSINHLGWMLSSMMISENLWLIYFLIYSIISLSIILLFNKFNIFFLNQlfNSNNKSKKIKFLLFLNLLSLG 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739 235 GMPPFLGFLMKWMSIKIISMSNPIFL-FFLIPSSLLNLFFYSRIMYPYFFKKMEINKMAQKMKKSGTMTAMNFLLMFLMI 313
Cdd:MTH00160  245 GLPPFLGFLPKWIIIQLLISNNMFFLlFILIMSSLITLYFYLRISYSSLMLNYNKNKWNLKKKKNKFSLILNFLSFISLF 324


                  ...
gi 1381394739 314 PMI 316
Cdd:MTH00160  325 GLI 327
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 42-263 1.41e-09

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 58.09  E-value: 1.41e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739  42 NSKNILSSNSMILYFIIQSLASSIFILSFLI---------------NFLMMVNYITMM----LITSAILIKLGAAPFHIW 102
Cdd:pfam00361  25 WGKSPRSSEAGMKYFLLTLLGSSILLFGISLmynytgtlsfdelskALTGGLNSSGLLllflLILVGFLFKSAQVPFHTW 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739 103 FPQVSEGL---------KFMPFSFLILNQKLIPLYILSFLNNSVMVMSIIFSS-LIGSFGGWNQNSIRKIIAFSTIAHLS 172
Cdd:pfam00361 105 LPDAYEGAptpvsallaATLVKAGGYGLIRRSLLYLPSSPFIQQILLILAIISmLLGSLAALVQTDIKRLLAYSSISHMG 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739 173 WMISIILCYNNW----WTMYFFMYSFIIITLIFFLFKTEMSYINQTNFFLDFS-------KKISLITILMSLGGMPPFLG 241
Cdd:pfam00361 185 YMLIALGAGTIYgiqaAIFHLLTHGLFSAGLFLCAGSVIYRRVHTRNIRDYGGlaktmpiLALVFLVAMLSLAGLPPTAG 264

                         250       260
                  ....*....|....*....|..
gi 1381394739 242 FLMKWMSIKIISMSNPIFLFFL 263
Cdd:pfam00361 265 FLGKFLILAAAVAASWIFLVLA 286
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
 44-285 4.09e-07

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 51.27  E-value: 4.09e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739  44 KNILSSNSMILYFIIQSLASSIFI--LSFL------INFLMMVNYIT------------MMLITSAILIKLGAAPFHIWF 103
Cdd:COG1007   147 DDRRSSEAALKYFLLGALSSGFLLygISLLygatgsLNLAGIAAALAagganspllllgLVLVLAGLAFKLSAVPFHMWT 226

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739 104 PQVSEGL------------KFMPFSFLI--LNQKLIPLYIlsFLNNSVMVMSIIfSSLIGSFGGWNQNSIRKIIAFSTIA 169
Cdd:COG1007   227 PDVYEGAptpvtaflatapKIAAFAALLrlLVEAFPGLAA--DWQLLLAVLAVL-SMTVGNLAALAQTNVKRMLAYSSIA 303

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739 170 HLSWMISIILCYNN--WWTMYFFMYSFIIITLIFFLFKTEMSY-------------INQTNFFLDFskkisLITILM-SL 233
Cdd:COG1007   304 HAGYLLLGLAAGTPlgVSAALFYLLAYLFMNLGAFAVILLLSRkggeaeeiedlagLARRSPLLAL-----AMTIFLlSL 378

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1381394739 234 GGMPPFLGFLMKWMSIK-IISMSNPIFLFFLIPSSLLNLFFYSRIMYPYFFKK 285
Cdd:COG1007   379 AGIPPTAGFFGKFYVFSaAVEAGLYWLAVIAVLNSVISAYYYLRVVKAMYFDE 431
NDH_I_N TIGR01770
proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th ...
 85-308 8.88e-07

proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. The Enzyme Commission designation 1.6.5.3, for NADH dehydrogenase (ubiquinone), is applied broadly, perhaps unfortunately, even if the quinone is menaquinone (Thermus, Mycobacterium) or plastoquinone (chloroplast). For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone. [Energy metabolism, Electron transport]


Pssm-ID: 273795 [Multi-domain]  Cd Length: 468  Bit Score: 49.95  E-value: 8.88e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739  85 LITSAILIKLGAAPFHIWFPQVSEG-----------LKFMPFSFLILNQKLIPLYILSFLNNSVMVMSIIFSSLIGSFGG 153
Cdd:TIGR01770 208 LILVGLLFKLSAVPFHMWVPDVYEGaptpvtaffsiVPKIAIFAVFLRLFLYILFGFSEAWQIFLAIIAFLSMLIGNFGA 287

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739 154 WNQNSIRKIIAFSTIAHLSWMISIILC--YNNWWTMYFFMYSFIIITLIFF-----LFKTEMSYINQTNFFLDFSKKISL 226
Cdd:TIGR01770 288 LAQKKVKRLLAYSSISHVGYILIGLLAgtLEGIKAVLFYIFIYALMSLGAFgvlslLRSYKDEWIEYISDFAGLFKTNPI 367

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739 227 ITILM-----SLGGMPPFLGFLMKWMSIKIISMSNPIFL-FFLIPSSLLNLFFYSRIMYPYFFKKMEINKMAQKMKKSGT 300
Cdd:TIGR01770 368 LAILIlifmfSLAGIPPLAGFFGKFYVFFALLKSGLYWLaVIAVLTSVIGAFYYLRVVKVMYFDKPERRIPSNPQSKAQS 447


                  ....*...
gi 1381394739 301 MTAMNFLL 308
Cdd:TIGR01770 448 LLLSISAL 455
 
Name Accession Description Interval E-value
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
 1-316 3.94e-60

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 195.04  E-value: 3.94e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739   1 MTTIILFWILILTVFMAMSTSSLFSLWICMEINMMMFM-PMMNSKNILSSNSMILYFIIQSLASSIFILSFLINFLMM-- 77
Cdd:MTH00160    5 SSKLLFLSTLIMGTLISISSNSWFGAWMGLEINLLSFIpLISNKKNLMSSESSLKYFLIQALASIILLFSIILNMLNLml 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739  78 VNYITMMLITSAILIKLGAAPFHIWFPQVSEGLKFMPFSFLILNQKLIPLYILS-FLNNSVMVMSIIFSSLIGSFGGWNQ 156
Cdd:MTH00160   85 FNNISSMLINSSLLLKLGAAPFHFWFPEVMEGLSWINCFILMTWQKIAPLILLSyLINNNFIIIIIILSAIIGAIGGLNQ 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739 157 NSIRKIIAFSTIAHLSWMISIILCYNNWWTMYFFMYSFIIITLIFFLFKTEMSYINQ--TNFFLDFSKKISLITILMSLG 234
Cdd:MTH00160  165 TSLRKILAYSSINHLGWMLSSMMISENLWLIYFLIYSIISLSIILLFNKFNIFFLNQlfNSNNKSKKIKFLLFLNLLSLG 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739 235 GMPPFLGFLMKWMSIKIISMSNPIFL-FFLIPSSLLNLFFYSRIMYPYFFKKMEINKMAQKMKKSGTMTAMNFLLMFLMI 313
Cdd:MTH00160  245 GLPPFLGFLPKWIIIQLLISNNMFFLlFILIMSSLITLYFYLRISYSSLMLNYNKNKWNLKKKKNKFSLILNFLSFISLF 324


                  ...
gi 1381394739 314 PMI 316
Cdd:MTH00160  325 GLI 327
ND2 MTH00112
NADH dehydrogenase subunit 2; Provisional
 1-279 4.65e-35

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214423 [Multi-domain]  Cd Length: 346  Bit Score: 129.94  E-value: 4.65e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739   1 MTTIILFWILILTVFMAMSTSSLFSLWICMEINMMMFM-PMMNSKNILSSNSMILYFIIQSLASSIFILSFLINFLM--- 76
Cdd:MTH00112    4 HAKLIITTSLILGTIITISSNHWLMAWTGLEINTLAIIpLISKPHHPRATEAATKYFLTQAAASALILFSSTTNAWNtgq 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739  77 -----MVNYITMMLITSAILIKLGAAPFHIWFPQVSEGLKFMPFSFLILNQKLIPLYIL----SFLNNSVMVMSIIFSSL 147
Cdd:MTH00112   84 wditqLTNPTSCTLLTLALAMKLGLAPFHFWLPEVLQGSTTTTALILSTWQKLAPLTLLlmtsNSLNPTLLLTLAILSTL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739 148 IGSFGGWNQNSIRKIIAFSTIAHLSWMISIILCYNNWWTMYFFMYSFIIITLIFFLFKTEMSYInqTNFFLDFSKKISLI 227
Cdd:MTH00112  164 IGGWGGLNQTQLRKIMAFSSIAHLGWMIAIITYSPKLTLLTFYIYILMTTPMFLTLNTTSTKTL--KDMMTSWTKSPTLN 241

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1381394739 228 TILM----SLGGMPPFLGFLMKWMSIKIISMSNPIFLFFLIP-SSLLNLFFYSRIMY 279
Cdd:MTH00112  242 TTLMltllSLAGLPPLTGFMPKWLILQELTKQNMTPTATIMAmLSLLSLFFYLRLTY 298
ND2 MTH00105
NADH dehydrogenase subunit 2; Provisional
 1-279 1.87e-33

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177167 [Multi-domain]  Cd Length: 347  Bit Score: 125.73  E-value: 1.87e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739   1 MTTIILFWILILTVFMAMSTSSLFSLWICMEINMMMFM-PMMNSKNILSSNSMILYFIIQSLASSIFILSFLINFLM--- 76
Cdd:MTH00105    4 LILIIIYLTLFLGTMITMISSHWLLAWIGLEMNMLAIIpILMKKHNPRSTEAATKYFLTQATASMLLMMAIIINLMYsgq 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739  77 -----MVNYITMMLITSAILIKLGAAPFHIWFPQVSEGLKFMPFSFLILNQKLIPLYIL----SFLNNSVMVMSIIFSSL 147
Cdd:MTH00105   84 wtitkLTNPTASTLMTIALAMKLGLAPFHFWVPEVTQGIPLSSGMILLTWQKLAPLSILyqisPSINPNLLLTLAILSIL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739 148 IGSFGGWNQNSIRKIIAFSTIAHLSWMISIILCYNNWWTMYFFMYsfIIITLIFFLFKTEMSYINQTNFFLDFSKK---- 223
Cdd:MTH00105  164 IGGWGGLNQTQLRKILAYSSIAHMGWMTAILPYNPTLTLLNLLIY--IIMTLTMFMLLMLNSSTTTLSLSHTWNKTplmt 241

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1381394739 224 ISLITILMSLGGMPPFLGFLMKWMSIKIISMSNPIFL-FFLIPSSLLNLFFYSRIMY 279
Cdd:MTH00105  242 SLILLTLLSLGGLPPLTGFMPKWMIIQELTKNNNIILpTLMAITALLNLYFYMRLIY 298
ND2 MTH00200
NADH dehydrogenase subunit 2; Provisional
 1-279 3.62e-31

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177246 [Multi-domain]  Cd Length: 347  Bit Score: 119.69  E-value: 3.62e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739   1 MTTIILFWILILTVFMAMSTSSLFSLWICMEINMMMFM-PMMNSKNILSSNSMILYFIIQSLASSIFILSFLIN------ 73
Cdd:MTH00200    4 LILPLFILSLGLGTLLTFSSSHWFLIWLGLEINTLAIIpLLIKQHHPRKVEATTKYFIIQATASALLLFGGLLNawtsgq 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739  74 --FLMMVNYITMMLITSAILIKLGAAPFHIWFPQVSEGLKFMPFSFLILNQKLIPLYILSFL----NNSVMVMSIIFSSL 147
Cdd:MTH00200   84 wgISEMLGPLSETLILLALALKLGLAPGHFWVPDVLQGLSLQTGLILSTWQKLAPFALLIQLapalNSNILLLLGLLSVL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739 148 IGSFGGWNQNSIRKIIAFSTIAHLSWMISIILCYNNWWTMYFFMYSFIIITLIFFLFKTEMSYINQTNFFLDFSKKISLI 227
Cdd:MTH00200  164 VGGWGGLNQTQLRKILAYSSIAHLGWLLSGLVYSPNLALLYLLLYVIITLTVFLLLNLLNSTKINSLSSSKTKNPILSML 243

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1381394739 228 T--ILMSLGGMPPFLGFLMKWMSIKIISM-SNPIFLFFLIPSSLLNLFFYSRIMY 279
Cdd:MTH00200  244 LglTLLSLGGLPPLTGFFPKWLILQELSKqGLFIYATILLLGSLLSLFFYLRLSY 298
ND2 MTH00144
NADH dehydrogenase subunit 2; Provisional
 4-316 2.54e-30

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214432 [Multi-domain]  Cd Length: 328  Bit Score: 116.91  E-value: 2.54e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739   4 IILFWILILTVFMAMSTSSLFSLWICMEINMMMFM-PMMNSKNILSSNSMILYFIIQSLASSIFILSFLINFLMMVNYIT 82
Cdd:MTH00144    7 LLFLFLMVMGTLLSLSSSHWLGVWVGLEINLIGFLpLLVYKKKSSESESVVKYFIIQSLGSSLLIFGSLIMYNLSFSWFS 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739  83 MMLITSAILIKLGAAPFHIWFPQVSEGLKFMPFSFLILNQKLIPLYILSFLNNS-----VMVMSIIFSSLIGSFGGWNQN 157
Cdd:MTH00144   87 MSLLLLGLCLKLGLFPFHFWVPSVMAGLSWLSCFLLLTWQKVAPLFLLSNFLDLywlayLLCVISVLSALVGSIGGLNQT 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739 158 SIRKIIAFSTIAHLSWMISIILCYNNWWTMYFFMYSFIIITLIFFLFKTEMSYI-NQTNFFLDFSKKISLITILMSLGGM 236
Cdd:MTH00144  167 QVRALLAYSSISHTGWMLVAILHGSWLMWMYFLIYIVSSGFLFFSLWSGDSGSMkDLGSLKPSYKTGLSIISLLLSLGGL 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739 237 PPFLGFLMKWMSIKIISMSNPIFLFF-LIPSSLLNLFFYSRIMYPYFFKKMEINKMAQKMKKSGTMTAMNFLLMFLMIPM 315
Cdd:MTH00144  247 PPFLGFCSKLLVLISSMESSPLLLILlLLLGSLISLFFYLSVFFSSFLSSSKSKKSNSSKVLNSSIISLNLLGGLLFLLL 326


                  .
gi 1381394739 316 I 316
Cdd:MTH00144  327 Y 327
ND2 MTH00041
NADH dehydrogenase subunit 2; Validated
 1-277 2.13e-29

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 177116 [Multi-domain]  Cd Length: 349  Bit Score: 114.64  E-value: 2.13e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739   1 MTTIILFWILILTVFMAMSTSSLFSLWICMEINMMMFMPMMNSKNILSSN-SMILYFIIQSLASSIFILSFLIN------ 73
Cdd:MTH00041    4 NVLIFLITSIILGTIIVISSNHWFLIWLGLELNTLSIIPILSSNFSPRSVeATIKYFLVQAFSAAILLNGALIQawlsgs 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739  74 --FLMMVNYITMMLITSAILIKLGAAPFHIWFPQVSEGLKFMPFSFLILNQKLIPLYIL----SFLNNSVMVMSIIFSSL 147
Cdd:MTH00041   84 wsINGPLNTLSSIIITLALALKLGLAPCHFWFPDVLQGLPFLQGLIIATWQKIAPLILLisisNLLNSNILILCGILSVL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739 148 IGSFGGWNQNSIRKIIAFSTIAHLSWMISIILcyNNWWTMYFFMYSFIIITLIFFLFKTEMSYINQTNF----FLDFSKK 223
Cdd:MTH00041  164 VGGWGGLNQTQTRKILAFSSIAHLGWIIITSA--YSPNASIIMFLIYIIINTSIFLIGNNFSLSTLSHLnklsQLNPISA 241

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1381394739 224 ISLITILMSLGGMPPFLGFLMKWMSIKIISMSNPIFL-FFLIPSSLLNLFFYSRI 277
Cdd:MTH00041  242 FLFILSILSLGGLPPLTGFLNKFISLYCLIQNNSILIsIILIIGSLLSLFFYLRI 296
ND2 MTH00197
NADH dehydrogenase subunit 2; Provisional
 5-316 7.66e-28

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177244 [Multi-domain]  Cd Length: 323  Bit Score: 110.15  E-value: 7.66e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739   5 ILFWILILTVFMAMSTSSLFSLWICMEINMM-MFMPMMNSKNILSSNSMILYFIIQSLASSIFILSFLINFL-MMVNYIT 82
Cdd:MTH00197    2 LFLFIIFGGVLFSLSSSNWFLVWIGMELNLIgFIPLLSQNKSITENEGAMKYFLFQEFGSALLLMGGSLSFSnLYLSLLS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739  83 MMLITSAILIKLGAAPFHIWFPQVSEGLKFMPFSFLILNQKLIPLYILSFLNNSVMVMSI--IFSSLIGSFGGWNQNSIR 160
Cdd:MTH00197   82 VVLVILGLLLKLGAFPFHFWVPSVMESLSWFNCFLLATWQKLAPLLILAFNSSSFMGLLIcsVLSSLIGGIGGMNQSNIR 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739 161 KIIAFSTIAHLSWMISIILCYNNWWTMYFFMYSFIIITLIFFLFKTEMSYINQTNFFLDF--SKKISLITILMSLGGMPP 238
Cdd:MTH00197  162 QLLAYSSIGHTGWMLMSLVYSPSIFMLYYLIYFVIMFMLFLFLSKNNLSSLNQQYSNPESmsSNLVFLGLSFLSLGGLPP 241

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1381394739 239 FLGFLMKWMSIK-IISMSNPIFLFFLIPSSLLNLFFYSRIMYPYFfkkMEINKMAQKMKKSGTMTAMNFLLMFLMIPMI 316
Cdd:MTH00197  242 LSGFFLKWLILTsLLSSNISLITFMLILSTCFSLYYYLSLAYKSL---ILSNWMINFLMKINLLYSGLFILLMMMLPLL 317
ND2 MTH00070
NADH dehydrogenase subunit 2; Provisional
 55-279 4.49e-27

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177142 [Multi-domain]  Cd Length: 346  Bit Score: 108.47  E-value: 4.49e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739  55 YFIIQSLASSIFILSFLIN--------FLMMVNYITMMLITSAILIKLGAAPFHIWFPQVSEGLKFMPFSFLILNQKLIP 126
Cdd:MTH00070   59 YFLTQASASALILFSSTINawftgewtIMNMQTPLPTIMLTIALMMKLGIAPFHFWLPEVLQGLDLTTGLILSTWQKLAP 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739 127 LYIL----SFLNNSVMVMSIIFSSLIGSFGGWNQNSIRKIIAFSTIAHLSWMISIILCYNNWWTMYFFMYsfIIITLIFF 202
Cdd:MTH00070  139 MALLiqisHLLNSNLLIIMGLLSTLIGGWGGLNQTQLRKIMAYSSIAHLGWMIIILTFSPHLTLLNLLIY--LIMTSSMF 216

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739 203 LFKTEMSYINQTNFFLDFSKKISLIT----ILMSLGGMPPFLGFLMKWMSIKIISMSNPIFLFFLIP-SSLLNLFFYSRI 277
Cdd:MTH00070  217 LMLMNLNSTNINKLSSSWSKNPTLTSmmmlTLLSLGGLPPTTGFIPKWLILQELTKQNLTTLATLMAlSALLSLFFYLRL 296


                  ..
gi 1381394739 278 MY 279
Cdd:MTH00070  297 SY 298
ND2 MTH00135
NADH dehydrogenase subunit 2; Provisional
 55-279 2.63e-26

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177193 [Multi-domain]  Cd Length: 347  Bit Score: 106.43  E-value: 2.63e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739  55 YFIIQSLASSIFILSFLIN--------FLMMVNYITMMLITSAILIKLGAAPFHIWFPQVSEGLKFMpfSFLILN--QKL 124
Cdd:MTH00135   59 YFLTQATAAAMILFASTTNawltgqwdIQQMSHPLPTTMITLALALKIGLAPLHFWLPEVLQGLDLT--TGLILStwQKL 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739 125 IP---LYILSFLNNSVMVMSIIFSSLIGSFGGWNQNSIRKIIAFSTIAHLSWMIsIILCYNNWWTMYFFMYSFIIITLIF 201
Cdd:MTH00135  137 APfalILQIAPTNPTLLITLGLTSTLVGGWGGLNQTQLRKILAYSSIAHLGWMI-LVLQFSPSLTLLALLTYIIMTSSAF 215

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739 202 FLFKTeMSYINQTNFFLDFSKKISLIT----ILMSLGGMPPFLGFLMKWMSIKIISMSN-PIFLFFLIPSSLLNLFFYSR 276
Cdd:MTH00135  216 LTFKL-NSSTKINTLATSWTKAPALTAltplILLSLGGLPPLTGFMPKWLILQELTKQDlPLTATLAALSALLSLYFYLR 294


                  ...
gi 1381394739 277 IMY 279
Cdd:MTH00135  295 LSY 297
ND2 MTH00011
NADH dehydrogenase subunit 2; Validated
 2-284 4.53e-23

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 164587 [Multi-domain]  Cd Length: 330  Bit Score: 97.16  E-value: 4.53e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739   2 TTIILFWILILTVFMAMSTSSLFSLWICMEINMMMFM-PMMNSKNILSSNSMILYFIIQSLASSIFILSFLINFLM--MV 78
Cdd:MTH00011    7 TMFLFSSTMTLGTLMALSSNNWLFLWMGMELNLLSFVpLMTSSKMNQESEAAVKYFLAQALGSGLLLLGMTMMWSFpsLL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739  79 NYITMMLITSAILIKLGAAPFHIWFPQVSEGLKFMPFSFLILNQKLIPLYILSFLNN----SVMVMSIIFSSLIGSFGGW 154
Cdd:MTH00011   87 KNITALMLLVSLMLKLGMAPCHFWFPSVMSSISWTLCLILSTWQKIAPLSILFFFTShnilPMMTSMAAMSALAGGLGGM 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739 155 NQNSIRKIIAFSTIAHLSWMISIILCYNNWWTMYFFMYSFIIITLIFFLFKTEMSYINQTNFFLD--FSKKISLITILMS 232
Cdd:MTH00011  167 NQTQLRPLLAYSSIGHMGWMTMISVFSPSMAILYFMTYIIITTPLMLLFAYLNAFSTKFNSKISSmsQTTSMSLFIMLLS 246

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1381394739 233 LGGMPPFLGFLMKWMSIK-IISMSNPIFLFFLIPSSLLNLFFYSRIMYPYFFK 284
Cdd:MTH00011  247 LGGLPPFTGFMPKLMAIEtLTSNSMILILLVLIVGSLMNLFYYLNLIFNFMYL 299
ND2 MTH00196
NADH dehydrogenase subunit 2; Provisional
 9-285 4.00e-14

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214453 [Multi-domain]  Cd Length: 365  Bit Score: 71.99  E-value: 4.00e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739   9 ILILTVFMAMSTSSLFSLWICMEINMMMFMPMMNSK--NILSSNSMILYFIIQSLASSIFIL----------SFLINFLM 76
Cdd:MTH00196    1 MVALGILCLISSSNWLSVYLAIELQTLSLFILIAQNrgSGYSAEAGLKYFVLGALSSGLFLFgcallcgttgGLHLSYIN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739  77 MVNY-----------ITMMLITSAILIKLGAAPFHIWFPQVSEGLKFMPFSFLILNQKLIPLYILSFLNNSVMVMSI--I 143
Cdd:MTH00196   81 LVLNsgqsfssvsvpIGYLLIIVALLFKLSVAPFHMWAPDVYEGAPTKTTALLAIVPKLGIFSILVSIGLNVNILLIggL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739 144 FSSLIGSFGGWNQNSIRKIIAFSTIAHLSWMISIILCYNNWWTMYFFMYSFIIITLIFFLFKTEMSYINQTNFFLDFSK- 222
Cdd:MTH00196  161 FSLFVGAIGALNQTKIKRLLAYSGIGHMGFVLWGIEIGSFESIQASLVYLFIYIIMSICVFSIILALNVYKNLIIEFSGl 240

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1381394739 223 -------KISLITILMSLGGMPPFLGFLMKWMSIKIISMSNPIFLFFL-IPSSLLNLFFYSRIMYPYFFKK 285
Cdd:MTH00196  241 srrlpilAITLALTFLSIAGIPPLVGFLGKWLILLSGVVYQYYLIFLLaVFCSVIAGVYYVRIVKILFFQA 311
ND2 MTH00198
NADH dehydrogenase subunit 2; Provisional
 84-283 1.22e-12

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214454 [Multi-domain]  Cd Length: 607  Bit Score: 68.35  E-value: 1.22e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739  84 MLITSAILIKLGAAPFHIWFPQVSEGLKfMPFSFLIlnqKLIPLYILSFLNNSVMVMS------IIFSSLIGSFGGWNQN 157
Cdd:MTH00198  303 LFITVAILFKLAAAPFHMWTPDVYEGAP-TPTTALI---AIIPKFTVYILLTSLVITSklllsvAIISLVVGAFGALNQT 378

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739 158 SIRKIIAFSTIAHLSWMISIILC--YNNWWTMYFFMYSFIIITLIFFLF-----------------KTEMSYINQTNFFL 218
Cdd:MTH00198  379 RIKRLLAYSGIGHIGFILIGVSAgtYESLQASWTYAVTYLVSALASFTVictleefgtrtptsrqrDGSFGNYNLVRRLV 458

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739 219 DFS--------KKISLITILMSLGGMPPFLGFLMKWM----SIKI-ISMSNPIFL---FFLIPSSLLNLFFYSRIMYPYF 282
Cdd:MTH00198  459 DLTilsrgqpyIAFSLAIVFLSLAGIPPLLGFLGKWFilvgSIKIaFSSSLSIYYlvaLFAIICTCISAFYYIRIVATIY 538


                  .
gi 1381394739 283 F 283
Cdd:MTH00198  539 F 539
ND2 MTH00199
NADH dehydrogenase subunit 2; Provisional
 3-284 7.82e-10

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177245 [Multi-domain]  Cd Length: 460  Bit Score: 59.65  E-value: 7.82e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739   3 TIILFWILILTVFMAMSTSSLFSLWICMEINMMMFMPMMNSK--NILSSNSMILYFIIQSLASSIFIL------------ 68
Cdd:MTH00199   99 SPILILIVALGSLLLVSSINWLSIYLAIELQTLTLFILVALKrdSAYSTEAGLKYFVLGAVSSGLFLFgcallygltget 178

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739  69 SFLINFLMMVNYITMMLITSAILIKLGAAPFHIWFPQVSEGLKFMPFSFLILNQKLIPLYILSFLN--NSVMVMSIIFSS 146
Cdd:MTH00199  179 SIQGINSILTGDVGKILITISLLFKLSAAPFHMWAPDVYEGAPTITTALLATVPKIGVFSILVQIGpvTNVVLICAVLSI 258

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739 147 LIGSFGGWNQNSIRKIIAFSTIAHLSWMISIILCYNNWWTMYFFMYSFIIITLIFFLFKTEMSYINQTNFFLDFSK---- 222
Cdd:MTH00199  259 IYGAIGALNQTKIKRLLAYSGIGHMGFILFGVAIGSFESIQASLIYMIIYVIMSICSFSIILSLKLTKGLIVEVSGlsrk 338

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1381394739 223 ----KISLITILMSLGGMPPFLGFLMKWMsIKIISMSNPIFLFFLIP--SSLLNLFFYSRIMYPYFFK 284
Cdd:MTH00199  339 npviALTLALTFLSIAGIPPLAGFLSKWL-ILLSGVSSGYYLICIIAvlSSVIAGVYYVRVVQIIYFQ 405
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 42-263 1.41e-09

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 58.09  E-value: 1.41e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739  42 NSKNILSSNSMILYFIIQSLASSIFILSFLI---------------NFLMMVNYITMM----LITSAILIKLGAAPFHIW 102
Cdd:pfam00361  25 WGKSPRSSEAGMKYFLLTLLGSSILLFGISLmynytgtlsfdelskALTGGLNSSGLLllflLILVGFLFKSAQVPFHTW 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739 103 FPQVSEGL---------KFMPFSFLILNQKLIPLYILSFLNNSVMVMSIIFSS-LIGSFGGWNQNSIRKIIAFSTIAHLS 172
Cdd:pfam00361 105 LPDAYEGAptpvsallaATLVKAGGYGLIRRSLLYLPSSPFIQQILLILAIISmLLGSLAALVQTDIKRLLAYSSISHMG 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739 173 WMISIILCYNNW----WTMYFFMYSFIIITLIFFLFKTEMSYINQTNFFLDFS-------KKISLITILMSLGGMPPFLG 241
Cdd:pfam00361 185 YMLIALGAGTIYgiqaAIFHLLTHGLFSAGLFLCAGSVIYRRVHTRNIRDYGGlaktmpiLALVFLVAMLSLAGLPPTAG 264

                         250       260
                  ....*....|....*....|..
gi 1381394739 242 FLMKWMSIKIISMSNPIFLFFL 263
Cdd:pfam00361 265 FLGKFLILAAAVAASWIFLVLA 286
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
 44-285 4.09e-07

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 51.27  E-value: 4.09e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739  44 KNILSSNSMILYFIIQSLASSIFI--LSFL------INFLMMVNYIT------------MMLITSAILIKLGAAPFHIWF 103
Cdd:COG1007   147 DDRRSSEAALKYFLLGALSSGFLLygISLLygatgsLNLAGIAAALAagganspllllgLVLVLAGLAFKLSAVPFHMWT 226

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739 104 PQVSEGL------------KFMPFSFLI--LNQKLIPLYIlsFLNNSVMVMSIIfSSLIGSFGGWNQNSIRKIIAFSTIA 169
Cdd:COG1007   227 PDVYEGAptpvtaflatapKIAAFAALLrlLVEAFPGLAA--DWQLLLAVLAVL-SMTVGNLAALAQTNVKRMLAYSSIA 303

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739 170 HLSWMISIILCYNN--WWTMYFFMYSFIIITLIFFLFKTEMSY-------------INQTNFFLDFskkisLITILM-SL 233
Cdd:COG1007   304 HAGYLLLGLAAGTPlgVSAALFYLLAYLFMNLGAFAVILLLSRkggeaeeiedlagLARRSPLLAL-----AMTIFLlSL 378

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1381394739 234 GGMPPFLGFLMKWMSIK-IISMSNPIFLFFLIPSSLLNLFFYSRIMYPYFFKK 285
Cdd:COG1007   379 AGIPPTAGFFGKFYVFSaAVEAGLYWLAVIAVLNSVISAYYYLRVVKAMYFDE 431
NDH_I_N TIGR01770
proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th ...
 85-308 8.88e-07

proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. The Enzyme Commission designation 1.6.5.3, for NADH dehydrogenase (ubiquinone), is applied broadly, perhaps unfortunately, even if the quinone is menaquinone (Thermus, Mycobacterium) or plastoquinone (chloroplast). For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone. [Energy metabolism, Electron transport]


Pssm-ID: 273795 [Multi-domain]  Cd Length: 468  Bit Score: 49.95  E-value: 8.88e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739  85 LITSAILIKLGAAPFHIWFPQVSEG-----------LKFMPFSFLILNQKLIPLYILSFLNNSVMVMSIIFSSLIGSFGG 153
Cdd:TIGR01770 208 LILVGLLFKLSAVPFHMWVPDVYEGaptpvtaffsiVPKIAIFAVFLRLFLYILFGFSEAWQIFLAIIAFLSMLIGNFGA 287

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739 154 WNQNSIRKIIAFSTIAHLSWMISIILC--YNNWWTMYFFMYSFIIITLIFF-----LFKTEMSYINQTNFFLDFSKKISL 226
Cdd:TIGR01770 288 LAQKKVKRLLAYSSISHVGYILIGLLAgtLEGIKAVLFYIFIYALMSLGAFgvlslLRSYKDEWIEYISDFAGLFKTNPI 367

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739 227 ITILM-----SLGGMPPFLGFLMKWMSIKIISMSNPIFL-FFLIPSSLLNLFFYSRIMYPYFFKKMEINKMAQKMKKSGT 300
Cdd:TIGR01770 368 LAILIlifmfSLAGIPPLAGFFGKFYVFFALLKSGLYWLaVIAVLTSVIGAFYYLRVVKVMYFDKPERRIPSNPQSKAQS 447


                  ....*...
gi 1381394739 301 MTAMNFLL 308
Cdd:TIGR01770 448 LLLSISAL 455
ND2 MTH00091
NADH dehydrogenase subunit 2; Provisional
 9-313 7.33e-06

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177154  Cd Length: 273  Bit Score: 46.79  E-value: 7.33e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739   9 ILILTVFMAMSTSSLFSLWICMEINMMMFmpmmnSKNILSSNSMILYFIIQSLASSIFILSFLINFLMMVnyitmmlits 88
Cdd:MTH00091    2 FLSLLNFMSLNIFVWWSVFLLMTLLFVFL-----NKGMGSYSSLFNYFVLQESLGLLFLLFSFGYFQFLI---------- 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739  89 aILIKLGAAPFHIWFPQVSEGLKFMPFSFLILNQKLIPLYILSFLNNSVMVMSIIFSSLIGSFGGWNQNSIRKIIAFSTI 168
Cdd:MTH00091   67 -LMMKIGVAPFHFWIFSVTNGLFGWNLMWFLTFQKLPFLLVLLQFFSKNFFFLLLFGLLICFFQMFLLKSYKNLLILSST 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739 169 AHLSWMISIilcynnwwtmyfFMYSFIIITLIFFLFKTEMSYINQTNFFLDFSKKISLITILMSLgGMPPFLGFLMKWMS 248
Cdd:MTH00091  146 ESFNWLILS------------FFFSFFNVFFLFFYYFLLMLFLIPKFNNVNKLNFVSWETLLVFM-NLPFSVTFFVKIFS 212

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1381394739 249 IKIISMSNPIFLFFlipssLLNLFFYSRIMYPYFFKKMEINKMAQKMKKSGTMTAMNFLLMFLMI 313
Cdd:MTH00091  213 LSEILKVLGFFLLF-----LLFLMFLSVLSLSFWLVNLSTKLFLMLFKYNKGFFFFFLPLMLLSL 272
PRK05777 PRK05777
NADH-quinone oxidoreductase subunit NuoN;
12-285 1.82e-05

NADH-quinone oxidoreductase subunit NuoN;


Pssm-ID: 235603 [Multi-domain]  Cd Length: 476  Bit Score: 45.97  E-value: 1.82e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739  12 LTVFMAMSTSSLFSLWICMeinmmmfmpmMNSKNILSSNSMILYFIIQSLASSIFI--LSFL------INFLMMVNYIT- 82
Cdd:PRK05777  126 LTLFLGLELLSLPLYALAA----------LRRDRRRSLEAAIKYFVLGALASGFLLygMSLLygatgsLSFAGIAKALAd 195

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739  83 -----------MMLITSAILIKLGAAPFHIWFPQVSEGL------------KFMPFSFLIlnqkliPLYILSFLNNS--- 136
Cdd:PRK05777  196 gsgnsllllfgLVFLLVGLAFKLSAVPFHMWTPDVYEGAptpvtaflatapKIAAFAVLL------RLLVVAFGGLSedw 269

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739 137 --VMVMSIIFSSLIGSFGGWNQNSIRKIIAFSTIAHLSWMISIILCYNN--------WWTMYFFMY--SFIIITLIFFLF 204
Cdd:PRK05777  270 qqVLAIIAIASMLVGNLAALSQTNIKRLLAYSSIAHAGYLLVGLAAGTAegysavlfYLLAYLFMTlgAFGVISLLRRKG 349

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739 205 K-----TEMSYINQTNFFLDFSkkislITILM-SLGGMPPFLGFLMKWMSIKIISMSNPIFL-FFLIPSSLLNLFFYSRI 277
Cdd:PRK05777  350 GeaesiSDFAGLSKRSPLLAAV-----MTIFMlSLAGIPPTAGFWGKFYVFEAAVEAGLWWLaVIGVLNSAIGAFYYLRV 424


                  ....*...
gi 1381394739 278 MYPYFFKK 285
Cdd:PRK05777  425 IKLMYFDE 432
HyfB COG0651
Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy ...
 6-279 1.45e-04

Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy production and conversion, Inorganic ion transport and metabolism];


Pssm-ID: 440416 [Multi-domain]  Cd Length: 430  Bit Score: 43.21  E-value: 1.45e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739   6 LFWILILTVFMAMSTSSLFSLWICMEINMMM----FMPMMNSKNILSSnsmILYFIIQSLASSIFILSFLI--------N 73
Cdd:COG0651   112 LFLLLLAGMNGAFLTGDLFNLFVFFEVMLLAsyglVALGGTKEALRAG---LKYLILNLVGSALFLLGVGLlygatgtlN 188

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739  74 FLMMVNYIT----------MMLITSAILIKLGAAPFHIWFPQV-SEG------------LKFMPFSFLILNQKLIPLYIL 130
Cdd:COG0651   189 MADLAARLAeldpglllaaFALLLVGFGIKAALFPLHFWLPDAyPAApspvsallsgllTKVGVYAILRVLTLLFGADPA 268

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739 131 SFLNNSVMVMSIIfSSLIGSFGGWNQNSIRKIIAFSTIAHLSWMISIILCYN---NWWTMYFFMYSFIIITLIFFLFKTE 207
Cdd:COG0651   269 LFLGTLLLVLGLL-TMLVGALGALAQRDLKRLLAYSSVSQIGYILLGLGLGTplgLAGALFHLLNHALAKALLFLAAGAI 347

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739 208 MSYINQTNFFL--DFSKKISLITIL-----MSLGGMPPFLGFLMKWMSIK-IISMSNPIFLFFLIPSSLLNLFFYSRIMY 279
Cdd:COG0651   348 ERATGTRDLDKlgGLGKRMPLTAAAfligaLALAGLPPLSGFVSKWLLLQaALEAGAWLLAAVLLLSSLLTLAYFVRIFG 427
PRK08375 PRK08375
putative monovalent cation/H+ antiporter subunit D; Reviewed
 143-285 2.58e-04

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 236251 [Multi-domain]  Cd Length: 487  Bit Score: 42.56  E-value: 2.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739 143 IFSSLIGSFGGWNQNSIRKIIAFSTIAHLSWMIsIILCYNNWW-----TMYFFMYSFIIITLIF----FLFKT------E 207
Cdd:PRK08375  279 LLSMLVGSLAALGQDDVKRVLAYSTVSQMGYIL-LGLALLTPLalaagLLHLLHHALMKGALFLaagaIEVTYgtrrlsE 357

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739 208 MSYINQTNFFLDFSkkislITIL-MSLGGMPPFLGFLMKWMSIK-IISMSNPIFLFFLIPSSLLNLFFYSRIMYPYFFKK 285
Cdd:PRK08375  358 LSGLGRRMPLTAAA-----FAVAsLSLIGVPPTSGFVSKWYLVVgAVEAGQWLVLAVLLASSLLALLYFLRIWYRAFFGP 432
PRK02504 PRK02504
NAD(P)H-quinone oxidoreductase subunit N;
81-262 1.55e-03

NAD(P)H-quinone oxidoreductase subunit N;


Pssm-ID: 235044 [Multi-domain]  Cd Length: 513  Bit Score: 40.03  E-value: 1.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739  81 ITMMLITSAILIKLGAAPFHIWFPQVSEGLKFMPFSFLILNQKL------IPLYILSFLNNS-----VMVMSIIFSSLIG 149
Cdd:PRK02504  211 LALVFVIAGIAFKISAVPFHQWTPDVYEGSPTPVVAFLSVGSKAagfalaIRLLVTAFPSFDeqwklLFTALAILSMVLG 290

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739 150 SFGGWNQNSIRKIIAFSTIAHLSW-MISIIL-CYNNWWTMYFFMYSFIIITLIFFLFKTEMSYINQTNFFLDFS---KKI 224
Cdd:PRK02504  291 NVVALAQTSMKRMLAYSSIGQAGFvMIGLVAgTEAGYASMVFYLLAYLFMNLGAFACVILFSLRTGTDQISDYAglyQKD 370

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1381394739 225 SLITI-----LMSLGGMPPFLGFLMKwmsikiismsnpIFLFF 262
Cdd:PRK02504  371 PLLTLglslcLLSLGGIPPLAGFFGK------------IYLFW 401
ndhB CHL00049
NADH dehydrogenase subunit 2
 80-245 2.54e-03

NADH dehydrogenase subunit 2


Pssm-ID: 176990 [Multi-domain]  Cd Length: 494  Bit Score: 39.22  E-value: 2.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739  80 YITMMLITSAILIKLGAAPFHIWFPQVSEGLKFMPFSFLILNQKL-----------IPLYILSFLNNSVMVMSIIFSSLI 148
Cdd:CHL00049  214 SIALIFITVGIGFKLSLAPFHQWTPDVYEGSPTPVVAFLSVTSKVaasalatrifdIPFYFSSNEWHLLLEILAILSMIL 293

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394739 149 GSFGGWNQNSIRKIIAFSTIAHLSWMISIILC---YNNWWTMYFFMYSFIIITLIFFLFKTEMSYINQTNFFLDFSK--- 222
Cdd:CHL00049  294 GNLIAITQTSMKRMLAYSSIGQIGYVIIGIIVgdsNDGYASMITYMLFYIFMNLGTFACIVLFGLRTGTDNIRDYAGlyt 373

                         170       180
                  ....*....|....*....|....*...
gi 1381394739 223 -----KISLITILMSLGGMPPFLGFLMK 245
Cdd:CHL00049  374 kdpflALSLALCLLSLGGIPPLAGFFGK 401
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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