|
Name |
Accession |
Description |
Interval |
E-value |
| Mcm2 |
COG1241 |
DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and ... |
63-727 |
1.02e-154 |
|
DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair];
Pssm-ID: 440854 [Multi-domain] Cd Length: 682 Bit Score: 464.66 E-value: 1.02e-154
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 63 DEIQQLINHYPkEQTTLVIDWSVILRKDMDLADDVITSPNKHAKAFENEVTDtvpqmalVDGKDGDDNVirgEELEVRYK 142
Cdd:COG1241 20 DEILELAQEYP-EKRSLVVDYNDLYSFDPDLADDLLENPDEVLEAAEEALRE-------IDLEPYDVSL---GDAHVRIT 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 143 NVEDPISVSDANTgAEVGNLVTIRGQISKATPPKPRVSVAAVQCRACGDITHYEQPKHGVNKPEGCRNdCNAPA--DPLL 220
Cdd:COG1241 89 NLPETVPIRDIRS-DHIGKLISVEGIVRKATEVKPKITEAAFECPRCGTETYVPQTGEKLQEPHECPG-CGRQGpfKLLP 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 221 EESEW-DThQLLRLKHPP-----GESDHdtHIDVHVTKDTAGGFSGGENVDVTGVLR---EDFGDFDTPIPDFYLEGHAV 291
Cdd:COG1241 167 EKSEFiDA-QKIRIQEPPedlpgGQQPQ--SIDVILEDDLVGEVRPGDRVTVTGILRieqRTSGRGKSTIFDLYLEANSI 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 292 ERHQSDYEEIDVSNHlDE--IKAIqsGENGDPFELLKNSIAPGITGgeiMDRIKLALGLQMFGGMRVDKADGTALRGDIH 369
Cdd:COG1241 244 EVEEKEFEEIEITEE-DEekIKEL--SKDPDIYEKIIASIAPSIYG---YEEIKEAIALQLFGGVPKVLPDGSRIRGDIH 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 370 TLMVGSPGTGKSQILEAVMSLTPRVSRVSGKNVSKTGLTASAVQDDFGDTQWTIEAGAFVKANKGTCIIDELDKVDGDAL 449
Cdd:COG1241 318 ILLVGDPGTAKSQLLRYAARLAPRGVYTSGKGSTAAGLTAAAVRDDFGTGRWTLEAGALVLADGGLACIDELDKMREEDR 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 450 SSLHSALETQRVDIAKAGIETRLQSETSLLGAANPTNERFIgpEIESYVEQIPLGDALRSRMDAVFLLKDEVDEERDGEI 529
Cdd:COG1241 398 SALHEAMEQQTISIAKAGIVATLNARCSVLAAANPKYGRFD--PYEPIAEQIDLPPTLLSRFDLIFVLRDKPDEERDREL 475
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 530 VEAIIDSIATGENVDT-VGEWDDSVQPDLDGDLVRAWVAHERQQNRITIDlDLLKQRIKKKYVSLRQ--ASKGSGAPINP 606
Cdd:COG1241 476 ARHILKVHRAGELLEQeIEEETEEVKPEIDPDLLRKYIAYARRNVFPVLT-EEAKDLIEDFYVDMRKkgEDEDSPVPITA 554
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 607 RKVPSMIRYSIASAKVRGGEQIRDEDIERSFEIIGATLGQIGVDA-DGNItdDAGAAKRNKQlKTQKEKRKAILD---EL 682
Cdd:COG1241 555 RQLEALIRLAEASARMRLSDTVTEEDAERAIRLVDSCLKDVGVDPeTGKF--DIDVIETGTS-KSQRDKMKLIKDiikEL 631
|
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|.
gi 2231636009 683 TDGVKTPAEI------ADELGLENSYVAKKLEDLAEDGDVMRPSTGEYRRI 727
Cdd:COG1241 632 EEESSGGAPIedvieeAEEEGIDREKAEELIEKLKRKGEIYEPKPGHYKKV 682
|
|
| MCM |
smart00350 |
minichromosome maintenance proteins; |
159-640 |
8.03e-86 |
|
minichromosome maintenance proteins;
Pssm-ID: 214631 [Multi-domain] Cd Length: 509 Bit Score: 279.92 E-value: 8.03e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 159 VGNLVTIRGQISKATPPKPRVSVAAVQCRACGDITHYEQPKHGVNKPEGC-RNDCNAPADPLL--EESEWDTHQLLRLKH 235
Cdd:smart00350 13 LGKLVRISGIVTRTSGVRPKLKRASFTCEKCGATLGPEIQSGRETEPTVCpPRECQSPTPFSLnhERSTFIDFQKIKLQE 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 236 -----PPGESDHdtHIDVHVTKDTAGGFSGGENVDVTGVLREDFGDFDTP----IPDF--YLEGHAVER--HQSDYEEID 302
Cdd:smart00350 93 speevPVGQLPR--SVDVILDGDLVDKAKPGDRVEVTGIYRNVPYGFKLNtvkgLPVFatYIEANHVRKldYKRSFEDSS 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 303 VSNHL---DEIKAIQS-GENGDPFELLKNSIAPGITGGEImdrIKLALGLQMFGGMRVDKADGTALRGDIHTLMVGSPGT 378
Cdd:smart00350 171 FSVQSlsdEEEEEIRKlSKDPDIYERLARSLAPSIYGHED---IKKAILLLLFGGVHKNLPDGMKIRGDINILLCGDPGT 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 379 GKSQILEAVMSLTPRVSRVSGKNVSKTGLTASAVQDDFGDtQWTIEAGAFVKANKGTCIIDELDKVDGDALSSLHSALET 458
Cdd:smart00350 248 AKSQLLKYVEKTAPRAVYTTGKGSSAVGLTAAVTRDPETR-EFTLEAGALVLADNGVCCIDEFDKMDDSDRTAIHEAMEQ 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 459 QRVDIAKAGIETRLQSETSLLGAANPTNERF---IGPEiesyvEQIPLGDALRSRMDAVFLLKDEVDEERDGEIVEAIID 535
Cdd:smart00350 327 QTISIAKAGITTTLNARCSVLAAANPIGGRYdpkLTPE-----ENIDLPAPILSRFDLLFVVLDEVDEERDRELAKHVVD 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 536 SiatgeNVDTVGEWDDSVQPDLDGDLVRAWV--AHERQQNRITidlDLLKQRIKKKYVSLRQ-----ASKGSGaPINPRK 608
Cdd:smart00350 402 L-----HRYSHPEEDEAFEPPLSQEKLRKYIayAREKIKPKLS---EEAADKLVKAYVDLRKedsqtESRSSI-PITVRQ 472
|
490 500 510
....*....|....*....|....*....|..
gi 2231636009 609 VPSMIRYSIASAKVRGGEQIRDEDIERSFEII 640
Cdd:smart00350 473 LESIIRLSEAHAKMRLSDVVEEADVEEAIRLL 504
|
|
| MCM_arch |
cd17761 |
archaeal MCM protein; archaeal MCM proteins form a homohexameric ring homologous to the ... |
323-639 |
1.15e-77 |
|
archaeal MCM protein; archaeal MCM proteins form a homohexameric ring homologous to the eukaryotic Mcm2-7 helicase and also function as the replicative helicase at the replication fork
Pssm-ID: 350667 [Multi-domain] Cd Length: 308 Bit Score: 251.60 E-value: 1.15e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 323 ELLKNSIAPGITGgeiMDRIKLALGLQMFGGMRVDKADGTALRGDIHTLMVGSPGTGKSQILEAVMSLTPRVSRVSGKNV 402
Cdd:cd17761 1 EKIISSIAPSIYG---HEDVKEAIALQLFGGVPKVLPDGTRIRGDIHILLVGDPGTAKSQLLKYVSKVAPRAVYTTGKGS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 403 SKTGLTASAVQDDFgDTQWTIEAGAFVKANKGTCIIDELDKVDGDALSSLHSALETQRVDIAKAGIETRLQSETSLLGAA 482
Cdd:cd17761 78 TAAGLTAAVVRDEG-TGEWYLEAGALVLADKGIAVVDEIDKMRKEDRSALHEAMEQQTISIAKAGIVATLNARAAVLAAA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 483 NPTNERFIgpEIESYVEQIPLGDALRSRMDAVFLLKDEVDEERDGEIVEAIIDSIATGENvdtvgewdDSVQPDLDGDLV 562
Cdd:cd17761 157 NPKFGRFD--SYRPVAEQIDLPPTLLSRFDLIFVLKDTPNEEKDRRLANHILDTHSGGEM--------REIKPEIDPDLL 226
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2231636009 563 RAWVAHERQQNRITIDlDLLKQRIKKKYVSLRQASKGSGA--PINPRKVPSMIRYSIASAKVRGGEQIRDEDIERSFEI 639
Cdd:cd17761 227 RKYIAYARKNVRPVLT-EEAKQLIKDFYVEMRKSGQETPSpvPITARQLEALVRLSEASARMRLSQEVTLEDAERAIRI 304
|
|
| MCM |
pfam00493 |
MCM P-loop domain; |
307-536 |
6.37e-69 |
|
MCM P-loop domain;
Pssm-ID: 459830 [Multi-domain] Cd Length: 224 Bit Score: 225.49 E-value: 6.37e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 307 LDEIKAIQsgENGDPFELLKNSIAPGITGgeiMDRIKLALGLQMFGGMRVDKADGTALRGDIHTLMVGSPGTGKSQILEA 386
Cdd:pfam00493 2 EEEIKELA--KRPDIYDKLADSIAPSIYG---HEDVKKAILLQLFGGVKKILPDGTRLRGDINVLLVGDPGTAKSQLLKY 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 387 VMSLTPRVSRVSGKNVSKTGLTASAVQDDFGDtQWTIEAGAFVKANKGTCIIDELDKVDGDALSSLHSALETQRVDIAKA 466
Cdd:pfam00493 77 VEKIAPRAVYTSGKGSSAAGLTAAVVRDPVTG-EFVLEAGALVLADGGVCCIDEFDKMNDEDRVALHEAMEQQTISIAKA 155
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 467 GIETRLQSETSLLGAANPTNERFigPEIESYVEQIPLGDALRSRMDAVFLLKDEVDEERDGEIVEAIIDS 536
Cdd:pfam00493 156 GIVATLNARCSILAAANPIFGRY--DPKKSIAENINLPPPLLSRFDLIFVLLDKPDEEKDERLAKHIVDL 223
|
|
| PTZ00111 |
PTZ00111 |
DNA replication licensing factor MCM4; Provisional |
161-686 |
2.61e-44 |
|
DNA replication licensing factor MCM4; Provisional
Pssm-ID: 173403 [Multi-domain] Cd Length: 915 Bit Score: 171.72 E-value: 2.61e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 161 NLVTIRGQISKATPPKPRVSVAAVQCRACGDI----------THYEQPKHG-VNKPEGCrNDCNAPADPLLEESE--WDT 227
Cdd:PTZ00111 228 SLVQFSGTVVRQTWIVPEITMACFRCRGQKKIglndyqpctcEHYEYVIQGeVNEPLLC-NECNSKYTFELNHNMcvYST 306
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 228 HQLLRL---KHPPGESDHDTHIDVHVTKDTAGGFSGGENVDVTGVLREDFGDFDTPIPDFYLEG---------------- 288
Cdd:PTZ00111 307 KKIVKLlqsNSSLNNPDKDGLDNSVDNSGLNGEIYMKDNEVINLNLYDDLIDSVKTGDRVTVVGilkvtpirtsttrrtl 386
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 289 HAVERHQSDYEEIDVSNHLDEIKAIQS----GENGD---------------P--FELLKNSIAPGITGgeiMDRIKLALG 347
Cdd:PTZ00111 387 KSLYTYFVNVIHVKVINSTNANQPEKGlkylGNENDfsdlqvykilelsrnPmiYRILLDSFAPSIKA---RNNVKIGLL 463
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 348 LQMFGGMR-VDKADGTA--------LRGDIHTLMVGSPGTGKSQILEAVMSLTPRVSRVSGKNVSKTGLTASAVQDDFGD 418
Cdd:PTZ00111 464 CQLFSGNKnSSDFNKSPdacykvdnFRGIINVLLCGDPGTAKSQLLHYTHLLSPRSIYTSGKSSSSVGLTASIKFNESDN 543
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 419 TQWTIEAGAFVKANKGTCIIDELDKVDGDALSSLHSALETQRVDIAKAGIETRLQSETSLLGAANPTNERFigPEIESYV 498
Cdd:PTZ00111 544 GRAMIQPGAVVLANGGVCCIDELDKCHNESRLSLYEVMEQQTVTIAKAGIVATLKAETAILASCNPINSRY--NKNKAVI 621
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 499 EQIPLGDALRSRMDAVFLLKDEVDEERDGEIVEAII------------DSIATGENVDTVGEWDDSVQPDL-----DGDL 561
Cdd:PTZ00111 622 ENINISPSLFTRFDLIYLVLDHIDQDTDQLISLSIAkdfllphmtgsgNDEDTYDRSNTMHVEDESLRSEKdynknDLDM 701
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 562 VRAWVAHE-----------------------RQQNRITIDLDLLKQRIKKKYVSLRQASKGSGAP-INPRKVPSMIRYSI 617
Cdd:PTZ00111 702 LRMYIKFSklhcfpklsdeakkvitreyvkmRQGNFQTSNLDELEHAQEDDDDDLYYQSSGTRMIyVSSRMISSIIRISV 781
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 618 ASAKVRGGEQIRDEDIERSFEIIGATLGQIGVD-ADGNITDDagaaKRNKQLKTQKEKRkaiLDELTDGV 686
Cdd:PTZ00111 782 SLARMRLSTVVTPADALQAVQIVKSSTFQSLVDpTTGKIDFD----QLHQGITTNKMQQ---LNQMYEQV 844
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Mcm2 |
COG1241 |
DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and ... |
63-727 |
1.02e-154 |
|
DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair];
Pssm-ID: 440854 [Multi-domain] Cd Length: 682 Bit Score: 464.66 E-value: 1.02e-154
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 63 DEIQQLINHYPkEQTTLVIDWSVILRKDMDLADDVITSPNKHAKAFENEVTDtvpqmalVDGKDGDDNVirgEELEVRYK 142
Cdd:COG1241 20 DEILELAQEYP-EKRSLVVDYNDLYSFDPDLADDLLENPDEVLEAAEEALRE-------IDLEPYDVSL---GDAHVRIT 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 143 NVEDPISVSDANTgAEVGNLVTIRGQISKATPPKPRVSVAAVQCRACGDITHYEQPKHGVNKPEGCRNdCNAPA--DPLL 220
Cdd:COG1241 89 NLPETVPIRDIRS-DHIGKLISVEGIVRKATEVKPKITEAAFECPRCGTETYVPQTGEKLQEPHECPG-CGRQGpfKLLP 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 221 EESEW-DThQLLRLKHPP-----GESDHdtHIDVHVTKDTAGGFSGGENVDVTGVLR---EDFGDFDTPIPDFYLEGHAV 291
Cdd:COG1241 167 EKSEFiDA-QKIRIQEPPedlpgGQQPQ--SIDVILEDDLVGEVRPGDRVTVTGILRieqRTSGRGKSTIFDLYLEANSI 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 292 ERHQSDYEEIDVSNHlDE--IKAIqsGENGDPFELLKNSIAPGITGgeiMDRIKLALGLQMFGGMRVDKADGTALRGDIH 369
Cdd:COG1241 244 EVEEKEFEEIEITEE-DEekIKEL--SKDPDIYEKIIASIAPSIYG---YEEIKEAIALQLFGGVPKVLPDGSRIRGDIH 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 370 TLMVGSPGTGKSQILEAVMSLTPRVSRVSGKNVSKTGLTASAVQDDFGDTQWTIEAGAFVKANKGTCIIDELDKVDGDAL 449
Cdd:COG1241 318 ILLVGDPGTAKSQLLRYAARLAPRGVYTSGKGSTAAGLTAAAVRDDFGTGRWTLEAGALVLADGGLACIDELDKMREEDR 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 450 SSLHSALETQRVDIAKAGIETRLQSETSLLGAANPTNERFIgpEIESYVEQIPLGDALRSRMDAVFLLKDEVDEERDGEI 529
Cdd:COG1241 398 SALHEAMEQQTISIAKAGIVATLNARCSVLAAANPKYGRFD--PYEPIAEQIDLPPTLLSRFDLIFVLRDKPDEERDREL 475
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 530 VEAIIDSIATGENVDT-VGEWDDSVQPDLDGDLVRAWVAHERQQNRITIDlDLLKQRIKKKYVSLRQ--ASKGSGAPINP 606
Cdd:COG1241 476 ARHILKVHRAGELLEQeIEEETEEVKPEIDPDLLRKYIAYARRNVFPVLT-EEAKDLIEDFYVDMRKkgEDEDSPVPITA 554
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 607 RKVPSMIRYSIASAKVRGGEQIRDEDIERSFEIIGATLGQIGVDA-DGNItdDAGAAKRNKQlKTQKEKRKAILD---EL 682
Cdd:COG1241 555 RQLEALIRLAEASARMRLSDTVTEEDAERAIRLVDSCLKDVGVDPeTGKF--DIDVIETGTS-KSQRDKMKLIKDiikEL 631
|
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|.
gi 2231636009 683 TDGVKTPAEI------ADELGLENSYVAKKLEDLAEDGDVMRPSTGEYRRI 727
Cdd:COG1241 632 EEESSGGAPIedvieeAEEEGIDREKAEELIEKLKRKGEIYEPKPGHYKKV 682
|
|
| MCM |
smart00350 |
minichromosome maintenance proteins; |
159-640 |
8.03e-86 |
|
minichromosome maintenance proteins;
Pssm-ID: 214631 [Multi-domain] Cd Length: 509 Bit Score: 279.92 E-value: 8.03e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 159 VGNLVTIRGQISKATPPKPRVSVAAVQCRACGDITHYEQPKHGVNKPEGC-RNDCNAPADPLL--EESEWDTHQLLRLKH 235
Cdd:smart00350 13 LGKLVRISGIVTRTSGVRPKLKRASFTCEKCGATLGPEIQSGRETEPTVCpPRECQSPTPFSLnhERSTFIDFQKIKLQE 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 236 -----PPGESDHdtHIDVHVTKDTAGGFSGGENVDVTGVLREDFGDFDTP----IPDF--YLEGHAVER--HQSDYEEID 302
Cdd:smart00350 93 speevPVGQLPR--SVDVILDGDLVDKAKPGDRVEVTGIYRNVPYGFKLNtvkgLPVFatYIEANHVRKldYKRSFEDSS 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 303 VSNHL---DEIKAIQS-GENGDPFELLKNSIAPGITGGEImdrIKLALGLQMFGGMRVDKADGTALRGDIHTLMVGSPGT 378
Cdd:smart00350 171 FSVQSlsdEEEEEIRKlSKDPDIYERLARSLAPSIYGHED---IKKAILLLLFGGVHKNLPDGMKIRGDINILLCGDPGT 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 379 GKSQILEAVMSLTPRVSRVSGKNVSKTGLTASAVQDDFGDtQWTIEAGAFVKANKGTCIIDELDKVDGDALSSLHSALET 458
Cdd:smart00350 248 AKSQLLKYVEKTAPRAVYTTGKGSSAVGLTAAVTRDPETR-EFTLEAGALVLADNGVCCIDEFDKMDDSDRTAIHEAMEQ 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 459 QRVDIAKAGIETRLQSETSLLGAANPTNERF---IGPEiesyvEQIPLGDALRSRMDAVFLLKDEVDEERDGEIVEAIID 535
Cdd:smart00350 327 QTISIAKAGITTTLNARCSVLAAANPIGGRYdpkLTPE-----ENIDLPAPILSRFDLLFVVLDEVDEERDRELAKHVVD 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 536 SiatgeNVDTVGEWDDSVQPDLDGDLVRAWV--AHERQQNRITidlDLLKQRIKKKYVSLRQ-----ASKGSGaPINPRK 608
Cdd:smart00350 402 L-----HRYSHPEEDEAFEPPLSQEKLRKYIayAREKIKPKLS---EEAADKLVKAYVDLRKedsqtESRSSI-PITVRQ 472
|
490 500 510
....*....|....*....|....*....|..
gi 2231636009 609 VPSMIRYSIASAKVRGGEQIRDEDIERSFEII 640
Cdd:smart00350 473 LESIIRLSEAHAKMRLSDVVEEADVEEAIRLL 504
|
|
| MCM_arch |
cd17761 |
archaeal MCM protein; archaeal MCM proteins form a homohexameric ring homologous to the ... |
323-639 |
1.15e-77 |
|
archaeal MCM protein; archaeal MCM proteins form a homohexameric ring homologous to the eukaryotic Mcm2-7 helicase and also function as the replicative helicase at the replication fork
Pssm-ID: 350667 [Multi-domain] Cd Length: 308 Bit Score: 251.60 E-value: 1.15e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 323 ELLKNSIAPGITGgeiMDRIKLALGLQMFGGMRVDKADGTALRGDIHTLMVGSPGTGKSQILEAVMSLTPRVSRVSGKNV 402
Cdd:cd17761 1 EKIISSIAPSIYG---HEDVKEAIALQLFGGVPKVLPDGTRIRGDIHILLVGDPGTAKSQLLKYVSKVAPRAVYTTGKGS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 403 SKTGLTASAVQDDFgDTQWTIEAGAFVKANKGTCIIDELDKVDGDALSSLHSALETQRVDIAKAGIETRLQSETSLLGAA 482
Cdd:cd17761 78 TAAGLTAAVVRDEG-TGEWYLEAGALVLADKGIAVVDEIDKMRKEDRSALHEAMEQQTISIAKAGIVATLNARAAVLAAA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 483 NPTNERFIgpEIESYVEQIPLGDALRSRMDAVFLLKDEVDEERDGEIVEAIIDSIATGENvdtvgewdDSVQPDLDGDLV 562
Cdd:cd17761 157 NPKFGRFD--SYRPVAEQIDLPPTLLSRFDLIFVLKDTPNEEKDRRLANHILDTHSGGEM--------REIKPEIDPDLL 226
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2231636009 563 RAWVAHERQQNRITIDlDLLKQRIKKKYVSLRQASKGSGA--PINPRKVPSMIRYSIASAKVRGGEQIRDEDIERSFEI 639
Cdd:cd17761 227 RKYIAYARKNVRPVLT-EEAKQLIKDFYVEMRKSGQETPSpvPITARQLEALVRLSEASARMRLSQEVTLEDAERAIRI 304
|
|
| MCM |
cd17706 |
MCM helicase family; MCM helicases are a family of helicases that play an important role in ... |
324-640 |
6.51e-74 |
|
MCM helicase family; MCM helicases are a family of helicases that play an important role in replication and homologous recombination repair. The heterohexameric ring-shaped Mcm2-7 complex is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases. Mcm8 and Mcm9, form a complex required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).
Pssm-ID: 350658 [Multi-domain] Cd Length: 311 Bit Score: 241.86 E-value: 6.51e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 324 LLKNSIAPGITGgeiMDRIKLALGLQMFGGMRVDKADGTALRGDIHTLMVGSPGTGKSQILEAVMSLTPRVSRVSGKNVS 403
Cdd:cd17706 1 ILADSIAPSIYG---HEDVKKAVLLQLFGGVQKILEDGTRIRGDIHILLVGDPGTAKSQILKYVLKIAPRGVYTSGKGSS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 404 KTGLTASAVQDDFGDtQWTIEAGAFVKANKGTCIIDELDKVDGDALSSLHSALETQRVDIAKAGIETRLQSETSLLGAAN 483
Cdd:cd17706 78 GAGLTAAVVRDSETG-EWYLEAGALVLADGGVCCIDEFDKMKELDRTALHEAMEQQTISIAKAGIVTTLNARCSILAAAN 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 484 PTNERFigPEIESYVEQIPLGDALRSRMDAVFLLKDEVDEERDGEIVEAIIDSiaTGENVDTVGEWDDSVQPDLDGDLVR 563
Cdd:cd17706 157 PKGGRY--NPKLSPIENINLPSPLLSRFDLIFVIRDDPDEERDEELAEHIIDL--HRGSDPEEQVKPEEDGIPIDIELLR 232
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2231636009 564 AWVAHERQ-QNRITidlDLLKQRIKKKYVSLRQASKGSGA-PINPRKVPSMIRYSIASAKVRGGEQIRDEDIERSFEII 640
Cdd:cd17706 233 KYILYARQiHPKIS---EEAREKLVRWYVELRKESERRSTiPITARQLESVIRLAEAHAKMRLSEVVTEEDVEEAIRLV 308
|
|
| MCM |
pfam00493 |
MCM P-loop domain; |
307-536 |
6.37e-69 |
|
MCM P-loop domain;
Pssm-ID: 459830 [Multi-domain] Cd Length: 224 Bit Score: 225.49 E-value: 6.37e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 307 LDEIKAIQsgENGDPFELLKNSIAPGITGgeiMDRIKLALGLQMFGGMRVDKADGTALRGDIHTLMVGSPGTGKSQILEA 386
Cdd:pfam00493 2 EEEIKELA--KRPDIYDKLADSIAPSIYG---HEDVKKAILLQLFGGVKKILPDGTRLRGDINVLLVGDPGTAKSQLLKY 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 387 VMSLTPRVSRVSGKNVSKTGLTASAVQDDFGDtQWTIEAGAFVKANKGTCIIDELDKVDGDALSSLHSALETQRVDIAKA 466
Cdd:pfam00493 77 VEKIAPRAVYTSGKGSSAAGLTAAVVRDPVTG-EFVLEAGALVLADGGVCCIDEFDKMNDEDRVALHEAMEQQTISIAKA 155
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 467 GIETRLQSETSLLGAANPTNERFigPEIESYVEQIPLGDALRSRMDAVFLLKDEVDEERDGEIVEAIIDS 536
Cdd:pfam00493 156 GIVATLNARCSILAAANPIFGRY--DPKKSIAENINLPPPLLSRFDLIFVLLDKPDEEKDERLAKHIVDL 223
|
|
| MCM4 |
cd17755 |
DNA replication licensing factor Mcm4; Mcm4 is a helicase that play an important role in ... |
324-640 |
9.12e-61 |
|
DNA replication licensing factor Mcm4; Mcm4 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.
Pssm-ID: 350661 [Multi-domain] Cd Length: 309 Bit Score: 206.52 E-value: 9.12e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 324 LLKNSIAPGITGgeiMDRIKLALGLQMFGGMRVDKAD-GTALRGDIHTLMVGSPGTGKSQILEAVMSLTPRVSRVSGKNV 402
Cdd:cd17755 1 RLARSIAPSIYE---LEDVKKGILLQLFGGTRKDFTKtGGKYRGDINILLCGDPGTSKSQLLQYVHKISPRGVYTSGKGS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 403 SKTGLTASAVQDDfgDT-QWTIEAGAFVKANKGTCIIDELDKVDGDALSSLHSALETQRVDIAKAGIETRLQSETSLLGA 481
Cdd:cd17755 78 SAVGLTAYVTRDP--DTkQLVLESGALVLSDGGICCIDEFDKMSDSTRSVLHEVMEQQTLSIAKAGIITTLNARTSILAS 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 482 ANPTNERFiGPEIeSYVEQIPLGDALRSRMDAVFLLKDEVDEERDGEIVEAIID-SIATGENvdtvgewddSVQPD-LDG 559
Cdd:cd17755 156 ANPIGSRY-NPKL-TVVENIDLPPTLLSRFDLIYLVLDKVDEKYDRRLAKHLVSlYLEDTPE---------HIQDEvLDV 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 560 DLVRAWVAHERqqNRITIDL-DLLKQRIKKKYVSLRQASKGSGAPIN--PRKVPSMIRYSIASAKVRGGEQIRDEDIERS 636
Cdd:cd17755 225 EVLTDYISYAR--EHIHPKLsEEAAQELVQAYVDMRKMGSDARKRITatPRQLESLIRLAEAHAKMRLSNVVEAEDVEEA 302
|
....
gi 2231636009 637 FEII 640
Cdd:cd17755 303 VRLI 306
|
|
| MCM6 |
cd17757 |
DNA replication licensing factor Mcm6; Mcm6 is a helicase that play an important role in ... |
325-643 |
2.79e-59 |
|
DNA replication licensing factor Mcm6; Mcm6 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.
Pssm-ID: 350663 [Multi-domain] Cd Length: 307 Bit Score: 202.60 E-value: 2.79e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 325 LKNSIAPGITGGEImdrIKLALGLQMFGGMRVDKADGTALRGDIHTLMVGSPGTGKSQILEAVMSLTPRVSRVSGKNVSK 404
Cdd:cd17757 2 LVRSIAPSIYGHEE---VKKGILLMLLGGVHKITREGISLRGDINVCIVGDPSTAKSQFLKYVEEFSPRAVYTSGKASSA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 405 TGLTASAVQD-DFGDTqwTIEAGAFVKANKGTCIIDELDKVDGDALSSLHSALETQRVDIAKAGIETRLQSETSLLGAAN 483
Cdd:cd17757 79 AGLTAAVVRDeETGDF--VIEAGALMLADNGICCIDEFDKMDIKDQVAIHEAMEQQTISITKAGIQATLNARTSILAAAN 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 484 PTNERFigPEIESYVEQIPLGDALRSRMDAVFLLKDEVDEERDGEIVEAIIDSIATGEnvdtvgewdDSVQPDLDGDLVR 563
Cdd:cd17757 157 PVGGRY--DRSKSLKQNINISAPIMSRFDLFFVLLDECNEVTDYAIASHIVDLHSKRE---------EAIEPPFTAEQLK 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 564 AWVAHERQ-QNRITidlDLLKQRIKKKYVSLRQASKGSGAP----INPRKVPSMIRYSIASAKVRGGEQIRDEDIERSFE 638
Cdd:cd17757 226 RYIAYARTfKPKLT---KEAKDELVEQYKELRQDDASGSTRssyrITVRQLESLIRLSEAIARLHCSDEVTPEHVEEAAR 302
|
....*
gi 2231636009 639 IIGAT 643
Cdd:cd17757 303 LLKKS 307
|
|
| MCM2 |
cd17753 |
DNA replication licensing factor Mcm2; Mcm2 is a helicase that play an important role in ... |
327-640 |
3.15e-58 |
|
DNA replication licensing factor Mcm2; Mcm2 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.
Pssm-ID: 350659 [Multi-domain] Cd Length: 325 Bit Score: 200.37 E-value: 3.15e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 327 NSIAPGITGgeiMDRIKLALGLQMFGGmrVDKADGTA--LRGDIHTLMVGSPGTGKSQILEAVMSLTPRVSRVSGKNVSK 404
Cdd:cd17753 4 NSIAPSIYG---HDDIKTAIALALFGG--VAKNPGGKhrIRGDINVLLLGDPGTAKSQFLKYVEKTAHRAVFTTGQGASA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 405 TGLTASaVQDDFGDTQWTIEAGAFVKANKGTCIIDELDKVDGDALSSLHSALETQRVDIAKAGIETRLQSETSLLGAANP 484
Cdd:cd17753 79 VGLTAS-VRKDPVTKEWTLEGGALVLADKGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCSVIAAANP 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 485 TNERFiGPEIeSYVEQIPLGDALRSRMDAVFLLKDEVDEERDGEIVEAIIDSIATG-----ENVDTVGEWDDSVQPDLDG 559
Cdd:cd17753 158 IGGRY-NPTL-TFAQNVNLTEPILSRFDILCVVRDTVDPEEDERLAKFVVGSHVRShpendEDREGEEEKNQRQRPKETK 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 560 ------DLVRAWVAHERQQNRITIDlDLLKQRIKKKYVSLRQAS-KGSGAPINPRKVPSMIRYSIASAKVRGGEQIRDED 632
Cdd:cd17753 236 vepipqELLRKYIHYAREKVRPKLN-QMDMDKVSRVYADLRKESmATGSLPITVRHLESIIRISEAHAKMHLREYVSEED 314
|
....*...
gi 2231636009 633 IERSFEII 640
Cdd:cd17753 315 VDMAIRVM 322
|
|
| MCM7 |
cd17758 |
DNA replication licensing factor Mcm7; Mcm7 is a helicase that play an important role in ... |
325-634 |
6.42e-57 |
|
DNA replication licensing factor Mcm7; Mcm7 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.
Pssm-ID: 350664 [Multi-domain] Cd Length: 306 Bit Score: 196.09 E-value: 6.42e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 325 LKNSIAPGITGGEimdRIKLALGLQMFGGmrVDK-ADGTALRGDIHTLMVGSPGTGKSQILEAVMSLTPRVSRVSGKNVS 403
Cdd:cd17758 2 LAASIAPEIYGHE---DVKKALLLLLVGG--VDKrGDGMKIRGDINICLMGDPGVAKSQLLKYICRIAPRSVYTTGRGSS 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 404 KTGLTAsAVQDDFGDTQWTIEAGAFVKANKGTCIIDELDKVDGDALSSLHSALETQRVDIAKAGIETRLQSETSLLGAAN 483
Cdd:cd17758 77 GVGLTA-AVMKDPVTGEMTLEGGALVLADQGICCIDEFDKMDESDRTAIHEVMEQQTISIAKAGITTTLNARTSILAAAN 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 484 PTNERFiGPEIeSYVEQIPLGDALRSRMDAVFLLKDEVDEERDGEIVEAIIdsiatgeNVDTVGEWDDSVQPDLDGDLVR 563
Cdd:cd17758 156 PAYGRY-NPRR-SPEQNINLPAALLSRFDLLFLILDKPDRDNDLRLAEHVT-------YVHQHNKQPDSDFEPLDPKLLR 226
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2231636009 564 AWVAHERQQnRITIDLDLLKqRIKKKYVSLRQASKGSGAP--INPRKVPSMIRYSIASAKVRGGEQIRDEDIE 634
Cdd:cd17758 227 AYIALAKRK-RPTVPPALAD-YIVQAYVEMRQEAKRSKDFtfTTPRTLLAILRLSQALARLRLSDSVEIDDVE 297
|
|
| MCM5 |
cd17756 |
DNA replication licensing factor Mcm5; Mcm5 is a helicase that play an important role in ... |
324-639 |
1.07e-56 |
|
DNA replication licensing factor Mcm5; Mcm5 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.
Pssm-ID: 350662 [Multi-domain] Cd Length: 317 Bit Score: 196.06 E-value: 1.07e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 324 LLKNSIAPGITGgeiMDRIKLALGLQMFGGMRVDKADGTALRGDIHTLMVGSPGTGKSQILEAVMSLTPRVSRVSGKNVS 403
Cdd:cd17756 1 IISKSIAPSIYG---NEDIKKAIACLLFGGSRKRLPDGMRLRGDINVLLLGDPGTAKSQLLKFVEKVAPIGVYTSGKGSS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 404 KTGLTASaVQDDFGDTQWTIEAGAFVKANKGTCIIDELDKVDGDALSSLHSALETQRVDIAKAGIETRLQSETSLLGAAN 483
Cdd:cd17756 78 AAGLTAS-VMRDPSTREFYLEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRTSVLAAAN 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 484 PTNERFigPEIESYVEQIPLGDALRSRMDAVFLLKDEVDEERDGEIVEAIIDsIATGENVDTVgewDDSVQPDLDGDLVR 563
Cdd:cd17756 157 PVFGRY--DDLKTPGDNIDFQTTILSRFDMIFIVKDKHDEERDITIAKHVIN-IHASARKASQ---SQENEGEIPISKLK 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 564 AWVAHERQQNRITIDLDLLKQrIKKKYVSLRQ--------ASKGSGAPINPRKVPSMIRYSIASAKVRGGEQIRDEDIER 635
Cdd:cd17756 231 RYIAYCRAKCAPRLSEEAAEK-LSNHYVTIRKdvrqneleSDNRSSIPITVRQLEAIIRISESLAKMELSPIATEKHVEE 309
|
....
gi 2231636009 636 SFEI 639
Cdd:cd17756 310 AIRL 313
|
|
| MCM3 |
cd17754 |
DNA replication licensing factor Mcm3; Mcm3 is a helicase that play an important role in ... |
324-640 |
3.69e-50 |
|
DNA replication licensing factor Mcm3; Mcm3 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.
Pssm-ID: 350660 [Multi-domain] Cd Length: 299 Bit Score: 177.66 E-value: 3.69e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 324 LLKNSIAPGITGGEimdRIKLALGLQMFGGMRVDKADGTALRGDIHTLMVGSPGTGKSQILEAVMSLTPRVSRVSGKNVS 403
Cdd:cd17754 1 LLSKSLAPSIYGHE---YIKKAILLMLLGGVEKNLENGSHLRGDINILLVGDPSVAKSQLLRYVLNTAPLAIATTGRGSS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 404 KTGLTAsAVQDDFGDTQWTIEAGAFVKANKGTCIIDELDKVDGDALSSLHSALETQRVDIAKAGIETRLQSETSLLGAAN 483
Cdd:cd17754 78 GVGLTA-AVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDIDRVAIHEVMEQQTVTIAKAGIHASLNARCSVLAAAN 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 484 PTNERFigPEIESYVEQIPLGDALRSRMDAVFLLKDEVDEERDGEIVEAIidsiatgenvdtvgewddsVQPDLDGDLVR 563
Cdd:cd17754 157 PVYGRY--DVYKTPMENIGLPDSLLSRFDLLFIVLDDIDEERDRSISEHV-------------------LRMHRYIKFLR 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 564 AWVAHERqqNRITIDL-DLLKQRIKKKYVSLRQA-----SKGSGAPINPRKVPSMIRYSIASAKVRGGEQIRDEDIERSF 637
Cdd:cd17754 216 KYIHYAK--ERIKPKLtQEAAEYIAEEYADLRNDdntktDKARTSPITARTLETLIRLATAHAKARLSKTVDKVDAEVAL 293
|
...
gi 2231636009 638 EII 640
Cdd:cd17754 294 NLL 296
|
|
| MCM8 |
cd17759 |
DNA helicase Mcm8; Mcm8 plays an important role homologous recombination repair. It forms a ... |
324-640 |
1.50e-45 |
|
DNA helicase Mcm8; Mcm8 plays an important role homologous recombination repair. It forms a complex with Mcm9 that is required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).
Pssm-ID: 350665 [Multi-domain] Cd Length: 289 Bit Score: 164.24 E-value: 1.50e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 324 LLKNSIAPGITGGEImdrIKLALGLQMFGGMR--VDKADGTALRGDIHTLMVGSPGTGKSQILEAVMSLTPRVSRVSGKN 401
Cdd:cd17759 1 LIVNSLCPAIYGHEL---VKAGLLLSLFGGKQkyADDKNRIPIRGDPHVLIVGDPGLGKSQMLQAACNIAPRGVYVCGNT 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 402 VSKTGLTASAVQD----DFGdtqwtIEAGAFVKANKGTCIIDELDKVdGDALSSLHSALETQRVDIAKAGIETRLQSETS 477
Cdd:cd17759 78 TTTSGLTVTLTKDgrsgDFA-----LEAGALVLGDQGICGIDEFDKM-GSQHQALLEAMEQQSVSLAKAGVVCSLPARTS 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 478 LLGAANPTNERFigPEIESYVEQIPLGDALRSRMDAVFLLKDEVDEERDGEIVEaiidsiatgenvdtvgewddsvqpdl 557
Cdd:cd17759 152 VIAAANPVGGHY--NKGKTVSENLKMGPALLSRFDLVFILLDTPSEEHDHLLSE-------------------------- 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 558 DGDLVRAWVAHERQQNRITIDLDlLKQRIKKKYVSLRQASKGSGA-PINPRKVPSMIRYSIASAKVRGGEQIRDEDIERS 636
Cdd:cd17759 204 HHQLLRKYISYARQYVNPVLSKD-ASEALQEFYLELRKQNQLADSsPITTRQLESLIRLTEARARLELREEATKEDAEDV 282
|
....
gi 2231636009 637 FEII 640
Cdd:cd17759 283 IEIM 286
|
|
| PTZ00111 |
PTZ00111 |
DNA replication licensing factor MCM4; Provisional |
161-686 |
2.61e-44 |
|
DNA replication licensing factor MCM4; Provisional
Pssm-ID: 173403 [Multi-domain] Cd Length: 915 Bit Score: 171.72 E-value: 2.61e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 161 NLVTIRGQISKATPPKPRVSVAAVQCRACGDI----------THYEQPKHG-VNKPEGCrNDCNAPADPLLEESE--WDT 227
Cdd:PTZ00111 228 SLVQFSGTVVRQTWIVPEITMACFRCRGQKKIglndyqpctcEHYEYVIQGeVNEPLLC-NECNSKYTFELNHNMcvYST 306
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 228 HQLLRL---KHPPGESDHDTHIDVHVTKDTAGGFSGGENVDVTGVLREDFGDFDTPIPDFYLEG---------------- 288
Cdd:PTZ00111 307 KKIVKLlqsNSSLNNPDKDGLDNSVDNSGLNGEIYMKDNEVINLNLYDDLIDSVKTGDRVTVVGilkvtpirtsttrrtl 386
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 289 HAVERHQSDYEEIDVSNHLDEIKAIQS----GENGD---------------P--FELLKNSIAPGITGgeiMDRIKLALG 347
Cdd:PTZ00111 387 KSLYTYFVNVIHVKVINSTNANQPEKGlkylGNENDfsdlqvykilelsrnPmiYRILLDSFAPSIKA---RNNVKIGLL 463
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 348 LQMFGGMR-VDKADGTA--------LRGDIHTLMVGSPGTGKSQILEAVMSLTPRVSRVSGKNVSKTGLTASAVQDDFGD 418
Cdd:PTZ00111 464 CQLFSGNKnSSDFNKSPdacykvdnFRGIINVLLCGDPGTAKSQLLHYTHLLSPRSIYTSGKSSSSVGLTASIKFNESDN 543
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 419 TQWTIEAGAFVKANKGTCIIDELDKVDGDALSSLHSALETQRVDIAKAGIETRLQSETSLLGAANPTNERFigPEIESYV 498
Cdd:PTZ00111 544 GRAMIQPGAVVLANGGVCCIDELDKCHNESRLSLYEVMEQQTVTIAKAGIVATLKAETAILASCNPINSRY--NKNKAVI 621
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 499 EQIPLGDALRSRMDAVFLLKDEVDEERDGEIVEAII------------DSIATGENVDTVGEWDDSVQPDL-----DGDL 561
Cdd:PTZ00111 622 ENINISPSLFTRFDLIYLVLDHIDQDTDQLISLSIAkdfllphmtgsgNDEDTYDRSNTMHVEDESLRSEKdynknDLDM 701
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 562 VRAWVAHE-----------------------RQQNRITIDLDLLKQRIKKKYVSLRQASKGSGAP-INPRKVPSMIRYSI 617
Cdd:PTZ00111 702 LRMYIKFSklhcfpklsdeakkvitreyvkmRQGNFQTSNLDELEHAQEDDDDDLYYQSSGTRMIyVSSRMISSIIRISV 781
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 618 ASAKVRGGEQIRDEDIERSFEIIGATLGQIGVD-ADGNITDDagaaKRNKQLKTQKEKRkaiLDELTDGV 686
Cdd:PTZ00111 782 SLARMRLSTVVTPADALQAVQIVKSSTFQSLVDpTTGKIDFD----QLHQGITTNKMQQ---LNQMYEQV 844
|
|
| MCM9 |
cd17760 |
DNA helicase Mcm9; Mcm9 plays an important role homologous recombination repair. It forms a ... |
324-632 |
3.55e-42 |
|
DNA helicase Mcm9; Mcm9 plays an important role homologous recombination repair. It forms a complex with Mcm8 that is required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).
Pssm-ID: 350666 [Multi-domain] Cd Length: 299 Bit Score: 155.40 E-value: 3.55e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 324 LLKNSIAPGITGgeiMDRIKLALGLQMFGGMRVDKADGTALRGDIHTLMVGSPGTGKSQILEAVMSLTPRVSRVSGKNVS 403
Cdd:cd17760 1 EILASLCPQVFG---LYNVKLAVAMVLAGGVQRIDASGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTAGIGST 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 404 KTGLTASAVQDdFGdtQWTIEAGAFVKANKGTCIIDELDKVDGDALSSLHSALETQRVDIAKAGIETRLQSETSLLGAAN 483
Cdd:cd17760 78 SAGLTVTAVKD-GG--EWNLEAGALVLADGGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATN 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 484 PTNErfIGPEiESYVEQIPLGDALRSRMDAVFLLKDEVDEERDGEIVEAIIDSiaTGENVDTVGEWDDsvqpdldgDLVR 563
Cdd:cd17760 155 PKGQ--YDPN-ESISVNIALASPLLSRFDLVLVLLDTKNEDWDRIISSFILEN--KGEPSKSSKLWSM--------EKMR 221
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 564 AWVAHERQ-QNRITIDLDLLkqrIKKKYVSLRQASKGSGAPINPRKVPSMIRYSIASAKVRGGEQIRDED 632
Cdd:cd17760 222 TYFCLIKNlRPVLSDEANAI---LLRYYQLQRQSDCRNAARTTIRMLESLIRLAEAHARLMFRETVTEED 288
|
|
| MCM_OB |
pfam17207 |
MCM OB domain; This family contains an OB-fold found within MCM proteins. This domain contains ... |
159-271 |
5.51e-12 |
|
MCM OB domain; This family contains an OB-fold found within MCM proteins. This domain contains an insertion at the zinc binding motif.
Pssm-ID: 465381 [Multi-domain] Cd Length: 126 Bit Score: 63.27 E-value: 5.51e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 159 VGNLVTIRGQISKATPPKPRVSVAAVQCRACGDITHYEqpkhgVNKPEGCRND-CNAPaDPLL---EESEWDTHQLLRL- 233
Cdd:pfam17207 10 IGKLVSVSGIVTRTSEVRPKLKKATFTCRKCGHTVGVK-----ITEPTKCPNPeCGNK-DPFKlvhEKSKFVDFQKIKIq 83
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 2231636009 234 ----KHPPGESDHdtHIDVHVTKDTAGGFSGGENVDVTGVLR 271
Cdd:pfam17207 84 espeEVPAGELPR--SLDVILDDDLVDRVKPGDRVTVTGIYR 123
|
|
| MCM_lid |
pfam17855 |
MCM AAA-lid domain; This entry represents the AAA-lid domain found in MCM proteins. |
560-640 |
8.45e-11 |
|
MCM AAA-lid domain; This entry represents the AAA-lid domain found in MCM proteins.
Pssm-ID: 465534 [Multi-domain] Cd Length: 86 Bit Score: 58.71 E-value: 8.45e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 560 DLVRAWVAHERQQNRITIDlDLLKQRIKKKYVSLRQASKGSGA--PINPRKVPSMIRYSIASAKVRGGEQIRDEDIERSF 637
Cdd:pfam17855 1 ELLRKYIAYAREKIKPKLS-EEAREKLVDAYVELRKESTGSGSsiPITVRQLESLIRLSEAHAKMRLSEIVTEEDVEEAI 79
|
...
gi 2231636009 638 EII 640
Cdd:pfam17855 80 RLL 82
|
|
| AAA_5 |
pfam07728 |
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ... |
369-511 |
3.05e-08 |
|
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.
Pssm-ID: 400191 [Multi-domain] Cd Length: 135 Bit Score: 53.07 E-value: 3.05e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 369 HTLMVGSPGTGKSQILEAVMSLTPRVSRVSgKNVSKtGLTASAVQD----DFGDTQWTieAGAFVKA--NKGTCIIDELD 442
Cdd:pfam07728 1 GVLLVGPPGTGKTELAERLAAALSNRPVFY-VQLTR-DTTEEDLFGrrniDPGGASWV--DGPLVRAarEGEIAVLDEIN 76
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 443 KVDGDALSSLHSALETQRVDIAKAGIETRLQSE-TSLLGAANPtnerfiGPEIESyveqiPLGDALRSRM 511
Cdd:pfam07728 77 RANPDVLNSLLSLLDERRLLLPDGGELVKAAPDgFRLIATMNP------LDRGLN-----ELSPALRSRF 135
|
|
| AAA |
cd00009 |
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ... |
369-496 |
1.30e-05 |
|
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.
Pssm-ID: 99707 [Multi-domain] Cd Length: 151 Bit Score: 45.60 E-value: 1.30e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 369 HTLMVGSPGTGKSQILEAVMSLTPRvSRVSGKNVSKTGLTASAV-QDDFGDTQWTIEAGAFVKANKGTCIIDELDKVDGD 447
Cdd:cd00009 21 NLLLYGPPGTGKTTLARAIANELFR-PGAPFLYLNASDLLEGLVvAELFGHFLVRLLFELAEKAKPGVLFIDEIDSLSRG 99
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 2231636009 448 ALSSLHSALETQRVDIAKagietrlQSETSLLGAANPTNERFIGPEIES 496
Cdd:cd00009 100 AQNALLRVLETLNDLRID-------RENVRVIGATNRPLLGDLDRALYD 141
|
|
| MCM_N |
pfam14551 |
MCM N-terminal domain; This family contains the N-terminal domain of MCM proteins. |
63-143 |
1.31e-04 |
|
MCM N-terminal domain; This family contains the N-terminal domain of MCM proteins.
Pssm-ID: 464206 [Multi-domain] Cd Length: 95 Bit Score: 41.51 E-value: 1.31e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231636009 63 DEIQQLINhypKEQTTLVIDWSVILRKDMDLADDVITSPNKHAKAFENEVTDTVPQMAlvdgkDGDDNVIRGEELEVRYK 142
Cdd:pfam14551 23 DQLREMIE---REQRSLEVDLDDLREFDPDLAEALLENPYEYLPLFEEALKEVVKELS-----EDPDYAEEEKEFQVRFY 94
|
.
gi 2231636009 143 N 143
Cdd:pfam14551 95 N 95
|
|
| HTH_ARSR |
cd00090 |
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ... |
673-716 |
1.33e-03 |
|
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.
Pssm-ID: 238042 [Multi-domain] Cd Length: 78 Bit Score: 38.05 E-value: 1.33e-03
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 2231636009 673 EKRKAILDELTDGVKTPAEIADELGLENSYVAKKLEDLAEDGDV 716
Cdd:cd00090 7 PTRLRILRLLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLV 50
|
|
| |
