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Conserved domains on  [gi|1025726434|gb|ANC56176|]
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NADH dehydrogenase subunit 4L (mitochondrion) [Indri indri]

Protein Classification

NADH-ubiquinone oxidoreductase chain 4L( domain architecture ID 10009568)

NADH-ubiquinone oxidoreductase chain 4L is a core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) and is believed to belong to the minimal assembly required for catalysis; Complex I functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 2.15e-37

NADH dehydrogenase subunit 4L; Provisional


:

Pssm-ID: 177169  Cd Length: 98  Bit Score: 121.19  E-value: 2.15e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1025726434  1 MPSISMNIILAFATALLGTLMFRSHLMSSLLCLEGMMLSMFTLSTLIILNMHFTMSFMMPILLLVLAACEAAVGLALLVM 80
Cdd:MTH00107   1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                         90
                 ....*....|....*...
gi 1025726434 81 VSNTYGLDYIQNLNLLQC 98
Cdd:MTH00107  81 VSNTYGTDYVQNLNLLQC 98
 
Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 2.15e-37

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177169  Cd Length: 98  Bit Score: 121.19  E-value: 2.15e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1025726434  1 MPSISMNIILAFATALLGTLMFRSHLMSSLLCLEGMMLSMFTLSTLIILNMHFTMSFMMPILLLVLAACEAAVGLALLVM 80
Cdd:MTH00107   1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                         90
                 ....*....|....*...
gi 1025726434 81 VSNTYGLDYIQNLNLLQC 98
Cdd:MTH00107  81 VSNTYGTDYVQNLNLLQC 98
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
3-98 4.10e-10

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 51.80  E-value: 4.10e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1025726434  3 SISMNIILAFATALLGtLMFRSHLMSSLLCLEGMMLSMFTLSTLIILNMHFTMSFMMPILLLVLAACEAAVGLALLVMVS 82
Cdd:pfam00420  1 AYLLLSGLLFLIGLYG-LLLRRNLLRVLLSLELMLNAVNLALVLFGRLTADPLPQALILTAIVIAAAEAAVGLALLVRIY 79

                         90
                 ....*....|....*.
gi 1025726434 83 NTYGLDYIQNLNLLQC 98
Cdd:pfam00420 80 RTHGTDDVDSLNLLKG 95
 
Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 2.15e-37

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177169  Cd Length: 98  Bit Score: 121.19  E-value: 2.15e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1025726434  1 MPSISMNIILAFATALLGTLMFRSHLMSSLLCLEGMMLSMFTLSTLIILNMHFTMSFMMPILLLVLAACEAAVGLALLVM 80
Cdd:MTH00107   1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                         90
                 ....*....|....*...
gi 1025726434 81 VSNTYGLDYIQNLNLLQC 98
Cdd:MTH00107  81 VSNTYGTDYVQNLNLLQC 98
ND4L MTH00126
NADH dehydrogenase subunit 4L; Provisional
 11-98 9.74e-20

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177185  Cd Length: 98  Bit Score: 76.16  E-value: 9.74e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1025726434 11 AFATALLGTLMFRSHLMSSLLCLEGMMLSMFTLSTLIILNMHFTMSFMMPILLLVLAACEAAVGLALLVMVSNTYGLDYI 90
Cdd:MTH00126  11 AFILGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWALQLESTSFSAAPMLLLAFSACEASAGLALLVATARTHGTDRL 90


                 ....*...
gi 1025726434 91 QNLNLLQC 98
Cdd:MTH00126  91 QNLNLLQC 98
ND4L MTH00125
NADH dehydrogenase subunit 4L; Provisional
 1-98 3.75e-19

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177184  Cd Length: 98  Bit Score: 74.88  E-value: 3.75e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1025726434  1 MPSISMNIILAFATALLGTLMFRSHLMSSLLCLEGMMLSMFTLSTLIILNMHFTMSFMMPILLLVLAACEAAVGLALLVM 80
Cdd:MTH00125   1 MTPTHFSLYTAFMLSLLGLSFHRTHLMSALLCLESMMLSLFIMLSLWPITTQTPSFTPMPIILLTFSACEAGTGLALLVA 80

                         90
                 ....*....|....*...
gi 1025726434 81 VSNTYGLDYIQNLNLLQC 98
Cdd:MTH00125  81 TTRTHGSDHLKNLNLLQC 98
ND4L MTH00067
NADH dehydrogenase subunit 4L; Provisional
 1-98 2.88e-15

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177139  Cd Length: 98  Bit Score: 65.01  E-value: 2.88e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1025726434  1 MPSISMNIILAFATALLGTLMFRSHLMSSLLCLEGMMLSMFTLSTLIILNMHFTMSFMMPILLLVLAACEAAVGLALLVM 80
Cdd:MTH00067   1 MSPTYFTFYSAFLLGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWSTQFESLSYFSLPMFMLTFSACEASTGLALMVA 80

                         90
                 ....*....|....*...
gi 1025726434 81 VSNTYGLDYIQNLNLLQC 98
Cdd:MTH00067  81 TTRTHGTDHLKNLNLLQC 98
ND4L MTH00181
NADH dehydrogenase subunit 4L; Provisional
 6-96 1.62e-10

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 214450  Cd Length: 93  Bit Score: 52.64  E-value: 1.62e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1025726434  6 MNIILAFATALLGTLMFRSHLMSSLLCLEGMMLSMFTLSTLIILNMHFTMSFMMPILLLVLAACEAAVGLALLVMVSNTY 85
Cdd:MTH00181   3 FVFISAFILLLLGLSLYKTHLLSLLLCLEGMMLFLFLLLALFSLLSSSSSMLMFGLILLTFSACEAVLGLSLLVATNRTH 82

                         90
                 ....*....|.
gi 1025726434 86 GLDYIQNLNLL 96
Cdd:MTH00181  83 GSDHLLKFNLL 93
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
3-98 4.10e-10

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 51.80  E-value: 4.10e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1025726434  3 SISMNIILAFATALLGtLMFRSHLMSSLLCLEGMMLSMFTLSTLIILNMHFTMSFMMPILLLVLAACEAAVGLALLVMVS 82
Cdd:pfam00420  1 AYLLLSGLLFLIGLYG-LLLRRNLLRVLLSLELMLNAVNLALVLFGRLTADPLPQALILTAIVIAAAEAAVGLALLVRIY 79

                         90
                 ....*....|....*.
gi 1025726434 83 NTYGLDYIQNLNLLQC 98
Cdd:pfam00420 80 RTHGTDDVDSLNLLKG 95
ND4L MTH00043
NADH dehydrogenase subunit 4L; Validated
 1-97 4.69e-09

NADH dehydrogenase subunit 4L; Validated


Pssm-ID: 214410  Cd Length: 98  Bit Score: 49.15  E-value: 4.69e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1025726434  1 MPSISMNIILAFATALLGTLMFRSHLMSSLLCLEGMMLSMFTLSTLIILNMHFTMSFMMPILLLVLAACEAAVGLALLVM 80
Cdd:MTH00043   1 MNIILIIILSSFFLGLLGILINRLHLLSILLCLELLLISLFLNISIWSLNYGNFSNLSFSLLLLTLSACEASIGLSLMVL 80

                         90
                 ....*....|....*..
gi 1025726434 81 VSNTYGLDYIQNLNLLQ 97
Cdd:MTH00043  81 LSRNHNSDLVASLNLLQ 97
ND4L MTH00188
NADH dehydrogenase subunit 4L; Provisional
 3-98 1.37e-07

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177237  Cd Length: 97  Bit Score: 45.35  E-value: 1.37e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1025726434  3 SISMNIILAFATALLGTLMFRSHLMSSLLCLEGMMLSMFTLSTLIILNMHFtmSFMMPILLLVLAACEAAVGLALLVMVS 82
Cdd:MTH00188   4 SMILVILLFVVLGLFTFLLNRKHLLMLLLSLEAIMLSLFWFLLVGLSYMEK--ELYLSLVLLTFAACEASVGLALLVSLI 81

                         90
                 ....*....|....*.
gi 1025726434 83 NTYGLDYIQNLNLLQC 98
Cdd:MTH00188  82 RSHGSDYVSSLNLIKC 97
ND4L MTH00162
NADH dehydrogenase subunit 4L; Provisional
 6-92 1.60e-05

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177218  Cd Length: 89  Bit Score: 39.75  E-value: 1.60e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1025726434  6 MNIILAFATALLGTLMFRSHLMSSLLCLEGMMLSMFTLstLIILNMHFTMSFMMPILLLVLAACEAAVGLALLVMVSNTY 85
Cdd:MTH00162   5 LIFLFMFFSGLLVFLSKRKHLLLMLLSLEFMVLSLFFL--LFLYLSFFNYELYFLLFFLTFSVCEGALGLSILVSMIRSH 82


                 ....*..
gi 1025726434 86 GLDYIQN 92
Cdd:MTH00162  83 GNDYFSS 89
ND4L MTH00149
NADH dehydrogenase subunit 4L; Provisional
 9-98 2.81e-05

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 214434  Cd Length: 97  Bit Score: 39.06  E-value: 2.81e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1025726434  9 ILAFATALLGTLMFRSHLMSSLLCLEGMMLSMFTLstLIILNMHFTMSFMMPILLLVLAACEAAVGLALLVMVSNTYGLD 88
Cdd:MTH00149  10 LFGFLMGVFALLFQYKHLLSILLSLEALMLSLLVM--MFSSSGLISFSSYLFLIILTFGACEASLGLSLLVSLIRLHGND 87

                         90
                 ....*....|
gi 1025726434 89 YIQNLNLLQC 98
Cdd:MTH00149  88 YVSSLSSLKF 97
ND4L MTH00013
NADH dehydrogenase subunit 4L; Validated
 1-98 1.28e-04

NADH dehydrogenase subunit 4L; Validated


Pssm-ID: 133655  Cd Length: 97  Bit Score: 37.42  E-value: 1.28e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1025726434  1 MPSISMNIILAFATALLGTLMFRSHLMSSLLCLEGMMLSMFTLSTLIILNMHfTMSFMMPILLLVLAACEAAVGLALLVM 80
Cdd:MTH00013   1 MMSPLFILSISPFISMFNLSLQRKHLLMSLLSLEAMILSLALFIPLSLMFAN-QVNGMLAIVLLTFGACEASLGLSLLVL 79

                         90
                 ....*....|....*...
gi 1025726434 81 VSNTYGLDYIQNLNLLQC 98
Cdd:MTH00013  80 MTRSYGNDMLKSLTSNKC 97
ND4L MTH00180
NADH dehydrogenase subunit 4L; Provisional
 9-97 7.96e-03

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177231  Cd Length: 99  Bit Score: 32.70  E-value: 7.96e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1025726434  9 ILAFATALLGTLMFRSHLMSSLLCLEGMMLSMFTLSTLIILNMHFTMSFMMPILLLVLAACEAAVGLALLVMVSNTYGLD 88
Cdd:MTH00180  10 IILFILGVLGIVLNRSNLIIMLMSIELMLLAISLLFLINSVAIDNLIGQIFTIMILTVAAAESAIGLAILVAYYRIRGTI 89


                 ....*....
gi 1025726434 89 YIQNLNLLQ 97
Cdd:MTH00180  90 AVKSLNLLR 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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