|
Name |
Accession |
Description |
Interval |
E-value |
| 2A060602 |
TIGR00918 |
The Eukaryotic (Putative) Sterol Transporter (EST) Family; |
31-1182 |
0e+00 |
|
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
Pssm-ID: 273338 [Multi-domain] Cd Length: 1145 Bit Score: 1780.97 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 31 SDLLRRPSYCHAAFALKQISKGKAVGQKAPLWIRARFQAFLFSLGCHIQRHCGKVLFIGLLVFGALSVGLRVAAIETDIE 110
Cdd:TIGR00918 7 SEYLQRPSYCDAAFALEQIDKGKATGRRAPLWLRAKFQRLLFTLGCYIQKHCGKVLFVGLLVFSAFAVGLRAANIETNVE 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 111 KLWVEAGSRVSKELRYTKEKQGEESVFTSQMLIQTPKQEGTNILTQEALLLHLEAALSASKVQVSLYGKSWDLNKICFKS 190
Cdd:TIGR00918 87 QLWVEVGGRVSQELAYTRQKIGEEAMFTPQLLIQTPHQEGANVLTPEALLQHLDSALKASRVHVYLYNRQWGLEHLCYKS 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 191 GVPIIENVMIERMIDKLFPCMIVTPLDCFWEGSKLQGGSAYLPGMPDIQWMNLDPLKLMEELSQFTS-LEGFREMLDKAQ 269
Cdd:TIGR00918 167 GEPSTEGGYIEQILEKLIPCLIITPLDCFWEGAKLQGGTAYLPGKPPLQWTNLDPASFLEELKQKMSqVESWEEMLKKAA 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 270 VGHAYMNRPCLDPSDTDCPHSAPNKDPWQVPNIAAELQGGCHGFSKKFMHWQEELILGERVKDSQNALQSAEALQTMFLL 349
Cdd:TIGR00918 247 VGQGYMERPCLNPADPDCPDTAPNKNSTQPPDVAAVLSGGCYGLSAKYMHWQEELIVGGTKRNRSGKLLSAQALQSMFQL 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 350 MSPKQLYEHFKDDYEIHDINWNEDKATAILESWQRKFVEVVHGSIPQNSSSNVYAFSTTTLNDIMKSFSDVSVIRVAGGY 429
Cdd:TIGR00918 327 MTPKQMYEHFKGYYKVHHIGWNEEKAAAVLEAWQRNFSEEVQQSLPKNSSQKILVFSSTTLDDILKKFSDVSAIRIVSGY 406
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 430 LLMLAYACVTMLRWDCAKSQGAVGLAGVLLVALSVAAGLGLCSLLGLSFNAATTQVLPFLALGIGVDDMFLLAHSFTETR 509
Cdd:TIGR00918 407 LLMLAYACLTMLRWDCAKSQGSVGLAGVLLVALSVAAGLGLCALLGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETG 486
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 510 SNIPFKERTGDCLRRTGTSVALTSINNMIAFFMAALVPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSLDLHRREDKRL 589
Cdd:TIGR00918 487 QNIPFEERTGECLKRTGASVVLTSISNVTAFFMAALIPIPALRAFSLQAAIVVVFNFAAVLLVFPAILSLDLRRREDRRL 566
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 590 DILCCFYSPCSSRVIQIQPQELSDANdnhqrapATPTYTgstittsTHITTTVQAFTQCDAAGQHIVTILPPTSQISTTP 669
Cdd:TIGR00918 567 DIFCCFFSPCSARVIQIEPQAYADGS-------APPVYS-------SHMQSTVQLRTEYDPGTQHYYTTNEPRSHLSVQP 632
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 670 psmvlstptptTDPYGSQVFTTSSSTRDLLAQVEEPKEgrECVPLPFFRWNLSSFAREKYAPLLLKPETKTVVVVVFVAL 749
Cdd:TIGR00918 633 -----------SDPLSCQSPDIAGSTRDLLSQFEDSKA--ACLSLPCARWTLATFAEKHYAPFLLQSWAKVVVIFLFLAL 699
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 750 LSLSLYGTTMVHDGLYLTDIVPRDTQEYEFITAQFKYFSFYNMYLVTMDGFDYARSQRQLLQLHNAFNSVKYVVKDGNHK 829
Cdd:TIGR00918 700 LGLSLYGTTRVQDGLDLTDIVPRDTNEHDFLDAQFRYFSFYNMYAVTQGNFDYPTQQQLLYDLHQSFSSVKYVLKEDNGQ 779
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 830 LPRMWLHYFQDWLKGLQATFDADWEAGKITYDSYRNGTEDGALAYKLLIQTGSKKEPFNYSQLTSRRLVDEDGLIPPEVF 909
Cdd:TIGR00918 780 LPRMWLHYFRDWLQGLQKAFDEDWRDGRITKENYRNGSDDAVLAYKLLVQTGHRDKPVDKEQLTTQRLVNADGIINPNAF 859
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 910 YIYLTVWVSNDPLGYAASQANFYPHPREWIHDKYDTTGENLRIPAAEPLEFAQFPFYLNGLRQASDFIEAIESVRTICEE 989
Cdd:TIGR00918 860 YIYLSAWVSNDPVAYAASQANIYPHPPEWLHDKNDYDPENLRIPAAEPLEYAQFPFYLNGLRETSQFVEAIEHVRAICNN 939
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 990 FMRQGIKNYPNGYPFLFWEQYIGLRHWFLLSISVVLACTFLVCAILLLNPWTAGVIVFILAMMTVELFGIMGLIGIKLSA 1069
Cdd:TIGR00918 940 YEGFGLPSYPSGYPFLFWEQYMGLRHWLLLSISVVLACTFLVCALLLLNPWTAGLIVLVLALMTVELFGMMGLLGIKLSA 1019
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 1070 IPVVILIASVGIGVEFTVHIALGFLTAIGDRNTRSAVAMEHMFAPVIDGAISTLLGVLMLAGSEFDFIMRYFFAVLAILT 1149
Cdd:TIGR00918 1020 IPVVILIASVGIGVEFTVHIALGFLTAIGDRNRRAVLALEHMFAPVLDGALSTLLGVLMLAGSEFDFIVRYFFAVLAVLT 1099
|
1130 1140 1150
....*....|....*....|....*....|...
gi 1032198935 1150 LLGILNGLVLLPVLLSLMGPPAEVVPANNANHL 1182
Cdd:TIGR00918 1100 CLGVLNGLVLLPVLLSMFGPEPEVSPAEGRSRL 1132
|
|
| Sterol-sensing |
pfam12349 |
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins ... |
445-595 |
6.11e-45 |
|
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.
Pssm-ID: 463544 [Multi-domain] Cd Length: 153 Bit Score: 159.67 E-value: 6.11e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 445 CAKSQGAVGLAGVLLVALSVAAGLGLCSLLGLSFNAATTQVLPFLALGIGVDDMFLLAHSFTETRSNIPFKERTGDCLRR 524
Cdd:pfam12349 1 MVKSKFGLGLAGVIIVLASVASSLGLCAYFGLPLTLIISEVIPFLVLAIGVDNIFLLVKAVVRTPRSLDVSERIAEALGE 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1032198935 525 TGTSVALTSINNMIAFFMAALVPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSLDLHRREDKRLDILCCF 595
Cdd:pfam12349 81 VGPSITLTSLTEILAFLLGALTDMPAVQEFCLFAAVAVLFDFLLQMTFFVAVLSLDIRRLESNRLDVACCI 151
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
483-1151 |
4.52e-15 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 80.67 E-value: 4.52e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 483 TQVLPFLALGIGVDD-MFLLAHSFTETRSNIPFKERTGDCLRRTGTSVALTSINNMIAFFMAALVPIPALRAFSLQAAVV 561
Cdd:COG1033 274 TILVPPLLLAIGIDYgIHLLNRYREERRKGLDKREALREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIG 353
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 562 VVFNFAMVLLIFPAILSLdLHRREDKRLDilccfyspcssrviqiqpqelsdandnhqrapatptytgstittsthittt 641
Cdd:COG1033 354 VLLAFLTSLTLLPALLSL-LPRPKPKTRR--------------------------------------------------- 381
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 642 vqaftqcdaagqhivtilpptsqisttppsmvlstptpttdpygsqvfttssstrdllaQVEEPKEGRecvplpFFRWnL 721
Cdd:COG1033 382 -----------------------------------------------------------LKKPPELGR------LLAK-L 395
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 722 SSFAREKYAPLLLkpetktvvvvVFVALLSLSLYGTTMVHDGLYLTDIVPRDTQEY---EFITAQFKyfSFYNMYLVTMD 798
Cdd:COG1033 396 ARFVLRRPKVILV----------VALVLAVVSLYGISRLKVEYDFEDYLPEDSPIRqdlDFIEENFG--GSDPLEVVVDT 463
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 799 GFDYARSQRQLLQlhnafnsvkyvvkdgnhklprmWLHYFQDWLKGLQatfdadwEAGKITydSYrngtedgALAYKLLI 878
Cdd:COG1033 464 GEPDGLKDPEVLK----------------------EIDRLQDYLESLP-------EVGKVL--SL-------ADLVKELN 505
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 879 QTGSKKEPFNYSqltsrrlvdedglIPPEVFYIYLTVWVSNDPLGYAASQanfyphpreWIHDKYDTTGENLRIPAAEPL 958
Cdd:COG1033 506 QALNEGDPKYYA-------------LPESRELLAQLLLLLSSPPGDDLSR---------FVDEDYSAARVTVRLKDLDSE 563
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 959 EFAQFpfylngLRQASDFIEaiesvrticEEFMRQGIKNYPNGYPFLFWEQYIGLRHWFLLSISVVLACTFLVCAILLLN 1038
Cdd:COG1033 564 EIKAL------VEEVRAFLA---------ENFPPDGVEVTLTGSAVLFAAINESVIESQIRSLLLALLLIFLLLLLAFRS 628
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 1039 pWTAGVIVFILAMMTVEL-FGIMGLIGIKLSAIPVVILIASVGIGVEFTVHIALGFLTAIG-DRNTRSAV--AMEHMFAP 1114
Cdd:COG1033 629 -LRLGLISLIPNLLPILLtFGLMGLLGIPLNIATAVVASIALGIGVDYTIHFLSRYREERRkGGDLEEAIrrALRTTGKA 707
|
650 660 670 680
....*....|....*....|....*....|....*....|....*.
gi 1032198935 1115 VIDGAISTLLGVLMLAGSEFDFImRYF---------FAVLAILTLL 1151
Cdd:COG1033 708 ILFTSLTLAAGFGVLLFSSFPPL-ADFglllalgllVALLAALLLL 752
|
|
| SLC-NCS1sbd_CobB-like |
cd11484 |
nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; This NCS1 ... |
1004-1151 |
7.99e-03 |
|
nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; This NCS1 subfamily includes Escherichia coli CodB (cytosine permease), and the Saccharomyces cerevisiae transporters: Fcy21p (Purine-cytosine permease), and vitamin B6 transporter Tpn1. NCS1s are essential components of salvage pathways for nucleobases and related metabolites; their known substrates include allantoin, uracil, thiamine, and nicotinamide riboside. NCS1s belong to a superfamily which also contains the solute carrier 5 family sodium/glucose transporters (SLC5s), and solute carrier 6 family neurotransmitter transporters (SLC6s).
Pssm-ID: 271377 [Multi-domain] Cd Length: 406 Bit Score: 40.29 E-value: 7.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 1004 FLFWEQYIGlrhWFllSISVVLACTFLVCAILLLNPWTAGVIVFILAMMTVELFGIMGLIGI-KLSAIPVVILI------ 1076
Cdd:cd11484 88 LLLGITQIG---WF--GVGTAMFAIALSKLLGINGSLWLLILIAGVLMTLTAIFGYKALHKLeKIAVPLIIALFvysvvl 162
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 1077 ------------------ASVGIGVEFTVHIALGFLTAIGD-----RNTRSAVAMEhMFAPVIDGAISTLLGVLMLA--- 1130
Cdd:cd11484 163 alrdygvgglaaltatgpLSFLVAVSLVAGSFISGATYTADysryaKSSKKAFWAT-FLGFFVGNSLMMILGALLAAatg 241
|
170 180
....*....|....*....|..
gi 1032198935 1131 -GSEFDFIMRYFFAVLAILTLL 1151
Cdd:cd11484 242 tADISEVMIAQGLGIPAILVLV 263
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| 2A060602 |
TIGR00918 |
The Eukaryotic (Putative) Sterol Transporter (EST) Family; |
31-1182 |
0e+00 |
|
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
Pssm-ID: 273338 [Multi-domain] Cd Length: 1145 Bit Score: 1780.97 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 31 SDLLRRPSYCHAAFALKQISKGKAVGQKAPLWIRARFQAFLFSLGCHIQRHCGKVLFIGLLVFGALSVGLRVAAIETDIE 110
Cdd:TIGR00918 7 SEYLQRPSYCDAAFALEQIDKGKATGRRAPLWLRAKFQRLLFTLGCYIQKHCGKVLFVGLLVFSAFAVGLRAANIETNVE 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 111 KLWVEAGSRVSKELRYTKEKQGEESVFTSQMLIQTPKQEGTNILTQEALLLHLEAALSASKVQVSLYGKSWDLNKICFKS 190
Cdd:TIGR00918 87 QLWVEVGGRVSQELAYTRQKIGEEAMFTPQLLIQTPHQEGANVLTPEALLQHLDSALKASRVHVYLYNRQWGLEHLCYKS 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 191 GVPIIENVMIERMIDKLFPCMIVTPLDCFWEGSKLQGGSAYLPGMPDIQWMNLDPLKLMEELSQFTS-LEGFREMLDKAQ 269
Cdd:TIGR00918 167 GEPSTEGGYIEQILEKLIPCLIITPLDCFWEGAKLQGGTAYLPGKPPLQWTNLDPASFLEELKQKMSqVESWEEMLKKAA 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 270 VGHAYMNRPCLDPSDTDCPHSAPNKDPWQVPNIAAELQGGCHGFSKKFMHWQEELILGERVKDSQNALQSAEALQTMFLL 349
Cdd:TIGR00918 247 VGQGYMERPCLNPADPDCPDTAPNKNSTQPPDVAAVLSGGCYGLSAKYMHWQEELIVGGTKRNRSGKLLSAQALQSMFQL 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 350 MSPKQLYEHFKDDYEIHDINWNEDKATAILESWQRKFVEVVHGSIPQNSSSNVYAFSTTTLNDIMKSFSDVSVIRVAGGY 429
Cdd:TIGR00918 327 MTPKQMYEHFKGYYKVHHIGWNEEKAAAVLEAWQRNFSEEVQQSLPKNSSQKILVFSSTTLDDILKKFSDVSAIRIVSGY 406
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 430 LLMLAYACVTMLRWDCAKSQGAVGLAGVLLVALSVAAGLGLCSLLGLSFNAATTQVLPFLALGIGVDDMFLLAHSFTETR 509
Cdd:TIGR00918 407 LLMLAYACLTMLRWDCAKSQGSVGLAGVLLVALSVAAGLGLCALLGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETG 486
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 510 SNIPFKERTGDCLRRTGTSVALTSINNMIAFFMAALVPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSLDLHRREDKRL 589
Cdd:TIGR00918 487 QNIPFEERTGECLKRTGASVVLTSISNVTAFFMAALIPIPALRAFSLQAAIVVVFNFAAVLLVFPAILSLDLRRREDRRL 566
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 590 DILCCFYSPCSSRVIQIQPQELSDANdnhqrapATPTYTgstittsTHITTTVQAFTQCDAAGQHIVTILPPTSQISTTP 669
Cdd:TIGR00918 567 DIFCCFFSPCSARVIQIEPQAYADGS-------APPVYS-------SHMQSTVQLRTEYDPGTQHYYTTNEPRSHLSVQP 632
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 670 psmvlstptptTDPYGSQVFTTSSSTRDLLAQVEEPKEgrECVPLPFFRWNLSSFAREKYAPLLLKPETKTVVVVVFVAL 749
Cdd:TIGR00918 633 -----------SDPLSCQSPDIAGSTRDLLSQFEDSKA--ACLSLPCARWTLATFAEKHYAPFLLQSWAKVVVIFLFLAL 699
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 750 LSLSLYGTTMVHDGLYLTDIVPRDTQEYEFITAQFKYFSFYNMYLVTMDGFDYARSQRQLLQLHNAFNSVKYVVKDGNHK 829
Cdd:TIGR00918 700 LGLSLYGTTRVQDGLDLTDIVPRDTNEHDFLDAQFRYFSFYNMYAVTQGNFDYPTQQQLLYDLHQSFSSVKYVLKEDNGQ 779
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 830 LPRMWLHYFQDWLKGLQATFDADWEAGKITYDSYRNGTEDGALAYKLLIQTGSKKEPFNYSQLTSRRLVDEDGLIPPEVF 909
Cdd:TIGR00918 780 LPRMWLHYFRDWLQGLQKAFDEDWRDGRITKENYRNGSDDAVLAYKLLVQTGHRDKPVDKEQLTTQRLVNADGIINPNAF 859
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 910 YIYLTVWVSNDPLGYAASQANFYPHPREWIHDKYDTTGENLRIPAAEPLEFAQFPFYLNGLRQASDFIEAIESVRTICEE 989
Cdd:TIGR00918 860 YIYLSAWVSNDPVAYAASQANIYPHPPEWLHDKNDYDPENLRIPAAEPLEYAQFPFYLNGLRETSQFVEAIEHVRAICNN 939
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 990 FMRQGIKNYPNGYPFLFWEQYIGLRHWFLLSISVVLACTFLVCAILLLNPWTAGVIVFILAMMTVELFGIMGLIGIKLSA 1069
Cdd:TIGR00918 940 YEGFGLPSYPSGYPFLFWEQYMGLRHWLLLSISVVLACTFLVCALLLLNPWTAGLIVLVLALMTVELFGMMGLLGIKLSA 1019
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 1070 IPVVILIASVGIGVEFTVHIALGFLTAIGDRNTRSAVAMEHMFAPVIDGAISTLLGVLMLAGSEFDFIMRYFFAVLAILT 1149
Cdd:TIGR00918 1020 IPVVILIASVGIGVEFTVHIALGFLTAIGDRNRRAVLALEHMFAPVLDGALSTLLGVLMLAGSEFDFIVRYFFAVLAVLT 1099
|
1130 1140 1150
....*....|....*....|....*....|...
gi 1032198935 1150 LLGILNGLVLLPVLLSLMGPPAEVVPANNANHL 1182
Cdd:TIGR00918 1100 CLGVLNGLVLLPVLLSMFGPEPEVSPAEGRSRL 1132
|
|
| 2A060601 |
TIGR00917 |
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ... |
68-1152 |
1.07e-53 |
|
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]
Pssm-ID: 273337 [Multi-domain] Cd Length: 1205 Bit Score: 206.68 E-value: 1.07e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 68 QAFLFSLGCHIQRHCGKVLFIGLLVFGALSVGLRVAAIETDIEKLWVEAGSRVSKELRYTKEKQGeeSVFTSQMLIQTPK 147
Cdd:TIGR00917 310 ARFFGKYGIWVARHPTLVICLSVSVVLLLCVGLIRFKVETRPVKLWVAPGSRAALEKQYFDTHFG--PFYRIEQLIIATV 387
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 148 QEGTN-----ILTQEALLLHLEAALSASKVQVSLYGKSWDLNKICFKSGVPIieNVMIERMIDKLFPCMIVtpldcfweg 222
Cdd:TIGR00917 388 QTSSHekapeILTDDNLKLLFDIQKKVSQLFANYEGELITLDSPCFKPNHPY--NCFIYSTCKKLQNMYSK--------- 456
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 223 sklqggsaylpgmpdiqwmnLDPLKlMEELSQFTSLEGFREmldkaqvgHAYMNRPCLDPsdtdcpHSAPnKDPWQVpni 302
Cdd:TIGR00917 457 --------------------LKPEN-YDDYGGVDYVKYCFE--------HFTSPESCLSA------FGGP-VDPTTV--- 497
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 303 aaelQGGCHGfskkfmhwqeelilgervkdsqNALQSAEALQTMFLLmspkqlyehfkddyeihDINWNEDKATAILESW 382
Cdd:TIGR00917 498 ----LGGFSG----------------------NNFSEASAFVVTFPV-----------------NNFVNKTNKTEKAVAW 534
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 383 QRKFVEVVHGSIPQNSSSNVYAFSTTTLNDIMKSFSDVSVIRVAGGYLLMLAYACVTM-----LRWDCAKSQGAVGLAGV 457
Cdd:TIGR00917 535 EKAFIQLAKDELLPMVQATISFSAERSIEDELKRESTADVITIAISYLVMFAYISLTLgdsprLKSLYVTSKVLLGLSGI 614
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 458 LLVALSVAAGLGLCSLLGLSFNAATTQVLPFLALGIGVDDMFLLAHSF-----------TETRSNIPFKERTGDCLRRTG 526
Cdd:TIGR00917 615 LIVMLSVLGSVGVFSAVGLKSTLIIMEVIPFLVLAVGVDNIFILVFFYfyleyfyrqvgVDNEQELTLERRLSRALMEVG 694
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 527 TSVALTSINNMIAFFMAALVPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSLDLHRREDKRLDILCCfyspcssrvIQI 606
Cdd:TIGR00917 695 PSITLASLSEILAFALGALIKMPAVRVFSMFAVLAVFLDFLLQITAFVALLVLDFKRTEDKRVDCFPC---------IKT 765
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 607 QPQELSDAndnhqrapatptytgstittsthitttvqaftqcdaagqhivtilpptsqisttppsmvlstptpttdpygs 686
Cdd:TIGR00917 766 SKSSISAE------------------------------------------------------------------------ 773
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 687 qvfTTSSSTRDLLAQVeepkegrecvplpffrwnlssFAREKYAPLLLKPETKTVVVVVFVALLSLSLYGTTMVHDGLYL 766
Cdd:TIGR00917 774 ---KGSGQRKAGLLTR---------------------YFKEVYAPVLLHWIVKIVVIAFFVGLLMAGIALSTRVEIGLDQ 829
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 767 TDIVPRDTqeyeFITAQFKYFSFY-----NMYLVTMDGFDYARSQRQLL----------QLHNAFNSVKYVVKDgnhklP 831
Cdd:TIGR00917 830 QIVLPQDS----YLQIYFASLTPLlevgpPFYIVIKGDYNYTDFESQNKlctmggcdkdSIVNVFNNLSYIAKP-----A 900
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 832 RMWLHYFQDWLKGlqatfDADWEAGKITYDSYRNGTEDGAlayklliqtgskkepFNYSQLTSrrlvDEDGLIPPEVFYI 911
Cdd:TIGR00917 901 SSWLDDYLVWLSP-----QASCCCRKFTNGTFCNGPDPQC---------------FRCADLSS----DAQGRPSTTQFKE 956
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 912 YLTVWVSNDPLGYAASQANFYphprewIHDKYDTTGENLRIPAAeplefaQFPFYLNGLRQASDFIEAIESVRTICEEFM 991
Cdd:TIGR00917 957 KLPWFLNALPSADCAKGGHAA------YSSAVDLQGYATIIQAS------SFRTYHTPLNTQVDFINAMRAAQEFAAKVS 1024
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 992 RQ-GIKNYPNGYPFLFWEQYIGLRHWFLLSISVVLACTFLVCAILL-LNPWTAGVIVFILAMMTVELFGIMGLIGIKLSA 1069
Cdd:TIGR00917 1025 RSsKMEVYPYSVFYVFFEQYLTIWKTAIINLSIALGAIFIVCLFLLqLNALSVVNLIMSVGMAVVFCVGIMHLWSISLNA 1104
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 1070 IPVVILIASVGIGVEFTVHIALGFLTAI-GDRNTRSAVAMEHMFAPVIDG-AISTLLGVLMLAGSEFDFIMRYFFAVLAI 1147
Cdd:TIGR00917 1105 VSVVNSVMHKGIAIEFCTHINAQFSTGKhFSRNHRAKEALGGMGSSVFSGiTLTKLVGVVVLGFSRSEIFVVYYFRMYLA 1184
|
....*
gi 1032198935 1148 LTLLG 1152
Cdd:TIGR00917 1185 LVLLG 1189
|
|
| Sterol-sensing |
pfam12349 |
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins ... |
445-595 |
6.11e-45 |
|
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.
Pssm-ID: 463544 [Multi-domain] Cd Length: 153 Bit Score: 159.67 E-value: 6.11e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 445 CAKSQGAVGLAGVLLVALSVAAGLGLCSLLGLSFNAATTQVLPFLALGIGVDDMFLLAHSFTETRSNIPFKERTGDCLRR 524
Cdd:pfam12349 1 MVKSKFGLGLAGVIIVLASVASSLGLCAYFGLPLTLIISEVIPFLVLAIGVDNIFLLVKAVVRTPRSLDVSERIAEALGE 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1032198935 525 TGTSVALTSINNMIAFFMAALVPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSLDLHRREDKRLDILCCF 595
Cdd:pfam12349 81 VGPSITLTSLTEILAFLLGALTDMPAVQEFCLFAAVAVLFDFLLQMTFFVAVLSLDIRRLESNRLDVACCI 151
|
|
| Patched |
pfam02460 |
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ... |
369-1130 |
5.17e-36 |
|
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.
Pssm-ID: 308203 [Multi-domain] Cd Length: 793 Bit Score: 147.89 E-value: 5.17e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 369 NWNEDKATAILESWQRKFVEVVHGSiPQNSSSNVYAFSTTTLNDIMKSFSDVSVIRVAGGYLLMLAYACVT-----MLRW 443
Cdd:pfam02460 164 KFDEEEVEEDSKEWEDELSQLLHNK-YASEHIQFTIFHDQILNDELVRNALTLTPFFVIGFFLLLTFSIIVsvtlsSYTI 242
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 444 DCAKSQGAVGLAGVLLVALSVAAGLGLCSLLGLSFNAATTqVLPFLALGIGVDDMFLLAHSFTETRSNIPFKERTGDCLR 523
Cdd:pfam02460 243 DWVRSKPILAALGLLSPVMAIVSSFGLLFWMGFPFNSIVC-VTPFLVLAIGVDDMFLMVAAWQRTTATLSVKKRMGEALS 321
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 524 RTGTSVALTSINNMIAFFMAALVPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSLdlhrredkrldilccfyspCSSRv 603
Cdd:pfam02460 322 EAGVSITITSLTDVLSFGIGTYTPTPAIQLFCAYTAVAIFFDFIYQITFFAAIMAI-------------------CAKP- 381
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 604 iqiqpqelsdandnhqrapatptytgstittsthitttvqaftqcDAAGQHiVTILPPTSQISTTppsmvlstptpttdp 683
Cdd:pfam02460 382 ---------------------------------------------EAEGRH-CLFVWATSSPQRI--------------- 400
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 684 ygsqvfTTSSSTRDLLAQVEEPKegrecvplpffrwnlSSFAREKYAPLLLKPETKTVVVVVFVALLSLSLYGTTMVHDG 763
Cdd:pfam02460 401 ------DSEGSEPDKSHNIEQLK---------------SRFFLDIYCPFLLNPSVRVCMLVLFVVYIAIAIYGCVNIKEG 459
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 764 LYLTDIVPRDT---QEYEFITAQF-KYFSFYNMYLVTMDGFDYARSQRQLLQLHNAFNSVKYVVKDgnhKLPRMWLHYFQ 839
Cdd:pfam02460 460 LEPDKLVLEDSplvEYLSLREKHFwPEGLQIQVAVNNPPNLTIPESRDRMNEMVDEFENTPYSLGP---NSTLFWLREYE 536
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 840 DWLKGLQATFdadweagkitydsyrngTEDGalayklliqtgskKEPFNYSQLTSrrlvdedglippevfyiyltvWVsn 919
Cdd:pfam02460 537 NFLSTLNMEE-----------------EEDE-------------EKEWSYGNLPS---------------------FL-- 563
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 920 dplgyaasQANFYPHPREWIHDKYDTTgenlripaaeplEFAQFPFYLNG--LRQASDFIEAIESVRTICEEFMRQGIKN 997
Cdd:pfam02460 564 --------KAPGNSHWAGDLVWDDNTT------------MVTKFRFTLAGkgLSTWNDRTRALQEWRSIADQYPEFNVTV 623
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 998 YPNGYPFLfwEQYIGLRHWFLLSISVVLACTFLVCAILLLNPWTAGVIVFILAMMTVELFGIMGLIGIKLSAIPVVILIA 1077
Cdd:pfam02460 624 FDEDAPFA--DQYLTILPSTIQNIVITLICMFIVCFLFIPNPPCVFVITLAIASIDIGVFGFLSLWGVDLDPISMITIIM 701
|
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|....
gi 1032198935 1078 SVGIGVEFTVHIALGFLTAIG-DRNTRSAVAMEHMFAPVIDGAISTLLGVLMLA 1130
Cdd:pfam02460 702 SIGFSVDFSAHIAYHFVRSRGdTPAERVVDALEALGWPVFQGGLSTILGVLVLL 755
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
483-1151 |
4.52e-15 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 80.67 E-value: 4.52e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 483 TQVLPFLALGIGVDD-MFLLAHSFTETRSNIPFKERTGDCLRRTGTSVALTSINNMIAFFMAALVPIPALRAFSLQAAVV 561
Cdd:COG1033 274 TILVPPLLLAIGIDYgIHLLNRYREERRKGLDKREALREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIG 353
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 562 VVFNFAMVLLIFPAILSLdLHRREDKRLDilccfyspcssrviqiqpqelsdandnhqrapatptytgstittsthittt 641
Cdd:COG1033 354 VLLAFLTSLTLLPALLSL-LPRPKPKTRR--------------------------------------------------- 381
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 642 vqaftqcdaagqhivtilpptsqisttppsmvlstptpttdpygsqvfttssstrdllaQVEEPKEGRecvplpFFRWnL 721
Cdd:COG1033 382 -----------------------------------------------------------LKKPPELGR------LLAK-L 395
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 722 SSFAREKYAPLLLkpetktvvvvVFVALLSLSLYGTTMVHDGLYLTDIVPRDTQEY---EFITAQFKyfSFYNMYLVTMD 798
Cdd:COG1033 396 ARFVLRRPKVILV----------VALVLAVVSLYGISRLKVEYDFEDYLPEDSPIRqdlDFIEENFG--GSDPLEVVVDT 463
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 799 GFDYARSQRQLLQlhnafnsvkyvvkdgnhklprmWLHYFQDWLKGLQatfdadwEAGKITydSYrngtedgALAYKLLI 878
Cdd:COG1033 464 GEPDGLKDPEVLK----------------------EIDRLQDYLESLP-------EVGKVL--SL-------ADLVKELN 505
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 879 QTGSKKEPFNYSqltsrrlvdedglIPPEVFYIYLTVWVSNDPLGYAASQanfyphpreWIHDKYDTTGENLRIPAAEPL 958
Cdd:COG1033 506 QALNEGDPKYYA-------------LPESRELLAQLLLLLSSPPGDDLSR---------FVDEDYSAARVTVRLKDLDSE 563
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 959 EFAQFpfylngLRQASDFIEaiesvrticEEFMRQGIKNYPNGYPFLFWEQYIGLRHWFLLSISVVLACTFLVCAILLLN 1038
Cdd:COG1033 564 EIKAL------VEEVRAFLA---------ENFPPDGVEVTLTGSAVLFAAINESVIESQIRSLLLALLLIFLLLLLAFRS 628
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 1039 pWTAGVIVFILAMMTVEL-FGIMGLIGIKLSAIPVVILIASVGIGVEFTVHIALGFLTAIG-DRNTRSAV--AMEHMFAP 1114
Cdd:COG1033 629 -LRLGLISLIPNLLPILLtFGLMGLLGIPLNIATAVVASIALGIGVDYTIHFLSRYREERRkGGDLEEAIrrALRTTGKA 707
|
650 660 670 680
....*....|....*....|....*....|....*....|....*.
gi 1032198935 1115 VIDGAISTLLGVLMLAGSEFDFImRYF---------FAVLAILTLL 1151
Cdd:COG1033 708 ILFTSLTLAAGFGVLLFSSFPPL-ADFglllalgllVALLAALLLL 752
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
962-1151 |
4.33e-13 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 74.13 E-value: 4.33e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 962 QFPFYLNGLRQASDFIEAIESVRTICEEFMRQGIKNYPNGYPFLFWEQYIGLRHWFLLSISVVLACTFLVCAILLLNPWT 1041
Cdd:COG1033 165 VVTLDPDPLSSDLDRKEVVAEIRAIIAKYEDPGVEVYLTGFPVLRGDIAEAIQSDLAIFFPLALLLILLLLFLFFRSLRG 244
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 1042 AGVIVFILAMMTVELFGIMGLIGIKLS----AIPVVILiasvGIGVEFTVHIALGFLTAI---GDRNTRSAVAMEHMFAP 1114
Cdd:COG1033 245 VLLPLLVVLLAVIWTLGLMGLLGIPLSpltiLVPPLLL----AIGIDYGIHLLNRYREERrkgLDKREALREALRKLGPP 320
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 1032198935 1115 VIDGAISTLLGVLMLAGSEFDfIMRYF---------FAVLAILTLL 1151
Cdd:COG1033 321 VLLTSLTTAIGFLSLLFSDIP-PIRDFgivaaigvlLAFLTSLTLL 365
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
478-588 |
1.01e-09 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 63.34 E-value: 1.01e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 478 FNAATTQVLPfLALGIGVDDMFLLAHSF-TETRSNIPFKERTGDCLRRTGTSVALTSINNMIAFFMAALVPIPALRAFSL 556
Cdd:COG1033 657 LNIATAVVAS-IALGIGVDYTIHFLSRYrEERRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLFSSFPPLADFGL 735
|
90 100 110
....*....|....*....|....*....|..
gi 1032198935 557 QAAVVVVFNFAMVLLIFPAILSLdLHRREDKR 588
Cdd:COG1033 736 LLALGLLVALLAALLLLPALLLL-LDPRIAKK 766
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
482-579 |
1.43e-07 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 56.00 E-value: 1.43e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 482 TTQVLPFLALGIGVDDMFLLAHSFTETRSNIPFKERTGDCLRRTGTSVALTSINNMIAFFMAALVPIPALRAFSLQAAVV 561
Cdd:TIGR00921 622 AMATTISIILGLGMDYSIHLAERYFEERKEHGPKEAITHTMERTGPGILFSGLTTAGGFLSLLLSHFPIMRNFGLVQGIG 701
|
90
....*....|....*...
gi 1032198935 562 VVFNFAMVLLIFPAILSL 579
Cdd:TIGR00921 702 VLSSLTAALVVFPALLVL 719
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
965-1151 |
3.06e-07 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 55.23 E-value: 3.06e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 965 FYLNGLRQaSDFIEAIESV-RTICEEFMRQGIKNYPNGYPFLFWEQYIGLRHWflLSISVVLAcTFLVCAILLL---NPW 1040
Cdd:TIGR00921 517 VIQVQLKQ-GEPKVQGRKIlRDVQHEHPPPGVKVGVTGLPVAFAEMHELVNEG--MRRMTIAG-AILVLMILLAvfrNPI 592
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 1041 TAgvIVFILAMMTVELF--GIMGLIGIKLSAIPVVILIASVGIGVEFTVHIALGFLTAIGDRNTRSAV--AMEHMFAPVI 1116
Cdd:TIGR00921 593 KA--VFPLIAIGSGILWaiGLMGLRGIPSFLAMATTISIILGLGMDYSIHLAERYFEERKEHGPKEAIthTMERTGPGIL 670
|
170 180 190
....*....|....*....|....*....|....*
gi 1032198935 1117 DGAISTLLGVLMLAGSEFDfIMRYFFAVLAILTLL 1151
Cdd:TIGR00921 671 FSGLTTAGGFLSLLLSHFP-IMRNFGLVQGIGVLS 704
|
|
| COG4258 |
COG4258 |
Predicted exporter [General function prediction only]; |
1018-1132 |
1.13e-04 |
|
Predicted exporter [General function prediction only];
Pssm-ID: 443400 [Multi-domain] Cd Length: 783 Bit Score: 46.77 E-value: 1.13e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 1018 LLSISVVLActFLVCAILLLNPWTAGVIVFILAMMTVELFGIMGLIGIKLSAIPVVILIASVGIGVEFTVHIALGFLTAI 1097
Cdd:COG4258 644 LLLLALLLI--LLLLLLRLRSLRRALRVLLPPLLAVLLTLAILGLLGIPLNLFHLIALLLVLGIGIDYALFFTEGLLDKG 721
|
90 100 110
....*....|....*....|....*....|....*
gi 1032198935 1098 GDRNTRSAVAMehmfapvidGAISTLLGVLMLAGS 1132
Cdd:COG4258 722 ELARTLLSILL---------AALTTLLGFGLLAFS 747
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
971-1153 |
6.27e-04 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 44.44 E-value: 6.27e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 971 RQASDFIEAIEsvRTICEEFMRQGIKNYPNGYPFLFWEQYIGlrhwFLLSISVVLACT-FLVCAILLL---NPWTAGVIV 1046
Cdd:TIGR00921 151 KQVVPIYNDVE--RSLERTNPPSGKFLDVTGSPAINYDIERE----FGKDMGTTMAISgILVVLVLLLdfkRWWRPLLPL 224
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 1047 FILAMMTVELFGIMGLIGIKLSAIPVVILIASVGIGVEFTVHIALGFLTAIGDRNTRSAVAMEHM--FAPVIDGA-ISTL 1123
Cdd:TIGR00921 225 VIILFGVAWVLGIMGWLGIPLYATTLLAVPMLIGVGIDYGIQTLNRYEEERDIGRAKGEAIVTAVrrTGRAVLIAlLTTS 304
|
170 180 190
....*....|....*....|....*....|
gi 1032198935 1124 LGVLMLAGSEFDFIMRyffavLAILTLLGI 1153
Cdd:TIGR00921 305 AGFAALALSEFPMVSE-----FGLGLVAGL 329
|
|
| YdfJ |
COG2409 |
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ... |
451-584 |
2.88e-03 |
|
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];
Pssm-ID: 441964 [Multi-domain] Cd Length: 697 Bit Score: 42.06 E-value: 2.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 451 AVGLAGVLLVALSVAaglglcsllglsFNAATTQVLPFLALGIGVD-DMFLLAhSFTETRSN-IPFKERTGDCLRRTGTS 528
Cdd:COG2409 208 GVALGLLALLAAFTD------------VSSFAPNLLTMLGLGVGIDyALFLVS-RYREELRAgEDREEAVARAVATAGRA 274
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 1032198935 529 V---ALTSInnmIAFFMAALVPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSLdLHRR 584
Cdd:COG2409 275 VlfsGLTVA---IALLGLLLAGLPFLRSMGPAAAIGVAVAVLAALTLLPALLAL-LGRR 329
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
478-594 |
4.66e-03 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 41.36 E-value: 4.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 478 FNAATTQVLPFLaLGIGVDDMFLLAHSFTETRSnipfKERTGD-----CLRRTGTSVALTSINNMIAFFMAALVPIPALR 552
Cdd:TIGR00921 245 LYATTLLAVPML-IGVGIDYGIQTLNRYEEERD----IGRAKGeaivtAVRRTGRAVLIALLTTSAGFAALALSEFPMVS 319
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 1032198935 553 AFSLQAAVVVVFNFAMVLLIFPAILSLDLHRREDKRLDILCC 594
Cdd:TIGR00921 320 EFGLGLVAGLITAYLLTLLVLPALLQSIDIGREKVKKEIIAI 361
|
|
| SLC-NCS1sbd_CobB-like |
cd11484 |
nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; This NCS1 ... |
1004-1151 |
7.99e-03 |
|
nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; This NCS1 subfamily includes Escherichia coli CodB (cytosine permease), and the Saccharomyces cerevisiae transporters: Fcy21p (Purine-cytosine permease), and vitamin B6 transporter Tpn1. NCS1s are essential components of salvage pathways for nucleobases and related metabolites; their known substrates include allantoin, uracil, thiamine, and nicotinamide riboside. NCS1s belong to a superfamily which also contains the solute carrier 5 family sodium/glucose transporters (SLC5s), and solute carrier 6 family neurotransmitter transporters (SLC6s).
Pssm-ID: 271377 [Multi-domain] Cd Length: 406 Bit Score: 40.29 E-value: 7.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 1004 FLFWEQYIGlrhWFllSISVVLACTFLVCAILLLNPWTAGVIVFILAMMTVELFGIMGLIGI-KLSAIPVVILI------ 1076
Cdd:cd11484 88 LLLGITQIG---WF--GVGTAMFAIALSKLLGINGSLWLLILIAGVLMTLTAIFGYKALHKLeKIAVPLIIALFvysvvl 162
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032198935 1077 ------------------ASVGIGVEFTVHIALGFLTAIGD-----RNTRSAVAMEhMFAPVIDGAISTLLGVLMLA--- 1130
Cdd:cd11484 163 alrdygvgglaaltatgpLSFLVAVSLVAGSFISGATYTADysryaKSSKKAFWAT-FLGFFVGNSLMMILGALLAAatg 241
|
170 180
....*....|....*....|..
gi 1032198935 1131 -GSEFDFIMRYFFAVLAILTLL 1151
Cdd:cd11484 242 tADISEVMIAQGLGIPAILVLV 263
|
|
| |
