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Conserved domains on  [gi|1034660265|ref|XP_016868902|]
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lymphocyte antigen 6H isoform X1 [Homo sapiens]

Protein Classification

LU domain-containing protein( domain architecture ID 10439911)

LU domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TFP_LU_ECD_Ly6H cd23549
extracellular domain (ECD) found in lymphocyte antigen 6H (Ly-6H) and similar proteins; Ly-6H ...
 52-139 1.55e-47

extracellular domain (ECD) found in lymphocyte antigen 6H (Ly-6H) and similar proteins; Ly-6H may act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro it inhibits alpha-3:beta-4-containing nAChRs maximum response. Ly-6H may play a role in the intracellular trafficking of alpha-7-containing nAChRs and may inhibit their expression at the cell surface. It seems to inhibit alpha-7/CHRNA7 signaling in hippocampal neurons. Ly-6H contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


:

Pssm-ID: 467079  Cd Length: 88  Bit Score: 149.52  E-value: 1.55e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034660265  52 LWCQDCTLTTNSSHCTPKQCQPSDTVCASVRITDPSSSRKDHSVNKMCASSCDFVKRHFFSDYLMGFINSGILKVDVDCC 131
Cdd:cd23549     1 LWCQDCTLTTNSSNCTPKPCQPSDTVCVSVRITDPSSSRKDHSVNKMCATSCDFTKRHFFSDYLMGFINSGILIVDVRCC 80


                  ....*...
gi 1034660265 132 EKDLCNGA 139
Cdd:cd23549    81 NKDLCNGP 88
 
Name Accession Description Interval E-value
TFP_LU_ECD_Ly6H cd23549
extracellular domain (ECD) found in lymphocyte antigen 6H (Ly-6H) and similar proteins; Ly-6H ...
 52-139 1.55e-47

extracellular domain (ECD) found in lymphocyte antigen 6H (Ly-6H) and similar proteins; Ly-6H may act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro it inhibits alpha-3:beta-4-containing nAChRs maximum response. Ly-6H may play a role in the intracellular trafficking of alpha-7-containing nAChRs and may inhibit their expression at the cell surface. It seems to inhibit alpha-7/CHRNA7 signaling in hippocampal neurons. Ly-6H contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467079  Cd Length: 88  Bit Score: 149.52  E-value: 1.55e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034660265  52 LWCQDCTLTTNSSHCTPKQCQPSDTVCASVRITDPSSSRKDHSVNKMCASSCDFVKRHFFSDYLMGFINSGILKVDVDCC 131
Cdd:cd23549     1 LWCQDCTLTTNSSNCTPKPCQPSDTVCVSVRITDPSSSRKDHSVNKMCATSCDFTKRHFFSDYLMGFINSGILIVDVRCC 80


                  ....*...
gi 1034660265 132 EKDLCNGA 139
Cdd:cd23549    81 NKDLCNGP 88
UPAR_LY6 pfam00021
u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.
 54-137 1.18e-13

u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.


Pssm-ID: 394978  Cd Length: 77  Bit Score: 62.56  E-value: 1.18e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034660265  54 CQDCTLTTNSSHCTPKQCQPSDTVCASVRITDPSSSRKDHSVNKMCA-SSCDfvkrhffsDYLMGFINSGILKVDVDCCE 132
Cdd:pfam00021   1 CYSCLGVSNEDCLSEVTCPLSDGQCVTTTLELPEGNLRGTVVSKGCArSSCP--------RLLSDFINGGIISVSESCCQ 72


                  ....*
gi 1034660265 133 KDLCN 137
Cdd:pfam00021  73 SDLCN 77
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 52-143 2.53e-05

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 40.60  E-value: 2.53e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034660265   52 LWCQDCTLTTNSSHCTPKQCQPSDTVCASVRITDPSSSRkDHSVNKMCASSCDFVKRHFFsdylmgFINSGILKVDVDCC 131
Cdd:smart00134   1 LQCYSCTGNPDSSCSSEEECRSPDDVCLTVVAEVISDSR-GSVVYKGCATSPICPGSHGY------EINLTIAFLKVSCC 73

                           90
                   ....*....|..
gi 1034660265  132 EKDLCNGAAGAG 143
Cdd:smart00134  74 QTDLCNAAGPGA 85
 
Name Accession Description Interval E-value
TFP_LU_ECD_Ly6H cd23549
extracellular domain (ECD) found in lymphocyte antigen 6H (Ly-6H) and similar proteins; Ly-6H ...
 52-139 1.55e-47

extracellular domain (ECD) found in lymphocyte antigen 6H (Ly-6H) and similar proteins; Ly-6H may act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro it inhibits alpha-3:beta-4-containing nAChRs maximum response. Ly-6H may play a role in the intracellular trafficking of alpha-7-containing nAChRs and may inhibit their expression at the cell surface. It seems to inhibit alpha-7/CHRNA7 signaling in hippocampal neurons. Ly-6H contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467079  Cd Length: 88  Bit Score: 149.52  E-value: 1.55e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034660265  52 LWCQDCTLTTNSSHCTPKQCQPSDTVCASVRITDPSSSRKDHSVNKMCASSCDFVKRHFFSDYLMGFINSGILKVDVDCC 131
Cdd:cd23549     1 LWCQDCTLTTNSSNCTPKPCQPSDTVCVSVRITDPSSSRKDHSVNKMCATSCDFTKRHFFSDYLMGFINSGILIVDVRCC 80


                  ....*...
gi 1034660265 132 EKDLCNGA 139
Cdd:cd23549    81 NKDLCNGP 88
UPAR_LY6 pfam00021
u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.
 54-137 1.18e-13

u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.


Pssm-ID: 394978  Cd Length: 77  Bit Score: 62.56  E-value: 1.18e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034660265  54 CQDCTLTTNSSHCTPKQCQPSDTVCASVRITDPSSSRKDHSVNKMCA-SSCDfvkrhffsDYLMGFINSGILKVDVDCCE 132
Cdd:pfam00021   1 CYSCLGVSNEDCLSEVTCPLSDGQCVTTTLELPEGNLRGTVVSKGCArSSCP--------RLLSDFINGGIISVSESCCQ 72


                  ....*
gi 1034660265 133 KDLCN 137
Cdd:pfam00021  73 SDLCN 77
TFP_LU_ECD_Ly6E cd23543
extracellular domain (ECD) found in lymphocyte antigen 6E (Ly-6E) and similar proteins; Ly-6E ...
 50-137 7.50e-07

extracellular domain (ECD) found in lymphocyte antigen 6E (Ly-6E) and similar proteins; Ly-6E (also called retinoic acid-induced gene E protein (RIG-E), or stem cell antigen 2 (SCA-2), or thymic shared antigen 1 (TSA-1)) is a GPI-anchored cell surface protein that regulates T-lymphocytes proliferation, differentiation, and activation. It restricts the entry of human coronaviruses, including SARS-CoV, MERS-CoV and SARS-CoV-2, by interfering with spike protein-mediated membrane fusion. It plays an essential role in placenta formation by acting as the main receptor for syncytin-A (SynA). It may also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. Ly-6E contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467073  Cd Length: 78  Bit Score: 44.65  E-value: 7.50e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034660265  50 HGLWCQDCTLTTNSSHC-TPKQCQPSDTVCASVRITDPSSSRKDHSVNKMCASSCDFVKrhffsdylmgfINSGILKVDV 128
Cdd:cd23543     1 HSLYCYTCENQSSNWNClKPTKCSDNDKYCVTTVASGGTGSSSGVRITKKCSPKCPETN-----------VNIGIASVST 69


                  ....*....
gi 1034660265 129 DCCEKDLCN 137
Cdd:cd23543    70 SCCQSSLCN 78
TFP_LU_ECD_GPIHBP1 cd23575
extracellular domain (ECD) found in glycosylphosphatidylinositol-anchored high density ...
 50-137 3.07e-06

extracellular domain (ECD) found in glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPI-HBP1) and similar proteins; GPI-HBP1 (also called GPI-anchored HDL-binding protein 1, or high density lipoprotein-binding protein 1) is an endothelial cell transporter for lipoprotein lipase. It mediates the transport of lipoprotein lipase LPL from the basolateral to the apical surface of endothelial cells in capillaries and anchors LPL on the surface of endothelial cells in the lumen of blood capillaries. GPI-HBP1 protects LPL against loss of activity, and against ANGPTL4-mediated unfolding. Thereby, it plays an important role in lipolytic processing of chylomicrons by LPL, triglyceride metabolism and lipid homeostasis. GPI-HBP1 binds chylomicrons and phospholipid particles that contain APOA5. It also binds high-density lipoprotein (HDL) and plays a role in the uptake of lipids from HDL. GPI-HBP1 contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467105  Cd Length: 83  Bit Score: 43.09  E-value: 3.07e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034660265  50 HGLWCQDCTLTTNSSHC-TPKQCQPSDTVCASVRITDPSSSRKDHSVNKMCASSCDFVKRhffsdylmgfiNSGILKVDV 128
Cdd:cd23575     1 HSLKCYTCVSAHSNSDClTETNCSSSDTYCKTLVASASGGSGSLTTITKWCASSCTPSTR-----------TVEGTKVTV 69


                  ....*....
gi 1034660265 129 DCCEKDLCN 137
Cdd:cd23575    70 SCCQTDLCN 78
TFP_LU_ECD_Ly6L cd23551
extracellular domain (ECD) found in lymphocyte antigen 6L (Ly-6L) and similar proteins; Ly-6L ...
 52-140 3.84e-06

extracellular domain (ECD) found in lymphocyte antigen 6L (Ly-6L) and similar proteins; Ly-6L (also called lymphocyte antigen 6 complex locus protein L) contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467081  Cd Length: 86  Bit Score: 43.16  E-value: 3.84e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034660265  52 LWCQDCTLTTNSSHCTPKQCQPSDTVCAS--VRITDPSSSRKDhsVNKMCASSCDFVKRHFFSDYLMGFINSGILKvdvd 129
Cdd:cd23551     2 LKCYQCFKVSSDEDCKPDQCAPSEIVCISneVVLYVGTKVRVL--ISKRCAPRCPNTNSRCEWSPGTQVIGSITRT---- 75

                          90
                  ....*....|.
gi 1034660265 130 CCEKDLCNGAA 140
Cdd:cd23551    76 CCSQSLCNRAP 86
TFP_LU_ECD_Ly6A_like cd23541
extracellular domain (ECD) found in mouse Ly-6A like lymphocyte antigens and similar proteins; ...
 51-137 4.80e-06

extracellular domain (ECD) found in mouse Ly-6A like lymphocyte antigens and similar proteins; The family includes mouse Ly-6 lymphocyte antigens, such as Ly-6A/Ly-6E, Ly-6B, Ly-6C1/6C2, Ly-6F, and Ly-6I/Ly-6M. Ly-6A/Ly-6E (also called stem cell antigen 1/SCA-1, or T-cell-activating protein/TAP) and Ly-6C are involved in T-cell activation. Members in this family contain an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467071  Cd Length: 83  Bit Score: 42.70  E-value: 4.80e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034660265  51 GLWCQDCTLTTNSSHCTPKQCQPSDTVCASVRITDPSSSRKDHSVNKMCASSCDfvKRHFFSDYLMGFInsgiLKVDVDC 130
Cdd:cd23541     2 GLRCYQCLGVPLETSCPSVTCSYPDGVCVSQEVETIVGSQRVKLKNKFCLPFCP--KNLYFLEEILGTT----VNVKTSC 75


                  ....*..
gi 1034660265 131 CEKDLCN 137
Cdd:cd23541    76 CKEDLCN 82
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 52-143 2.53e-05

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 40.60  E-value: 2.53e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034660265   52 LWCQDCTLTTNSSHCTPKQCQPSDTVCASVRITDPSSSRkDHSVNKMCASSCDFVKRHFFsdylmgFINSGILKVDVDCC 131
Cdd:smart00134   1 LQCYSCTGNPDSSCSSEEECRSPDDVCLTVVAEVISDSR-GSVVYKGCATSPICPGSHGY------EINLTIAFLKVSCC 73

                           90
                   ....*....|..
gi 1034660265  132 EKDLCNGAAGAG 143
Cdd:smart00134  74 QTDLCNAAGPGA 85
TFP_LU_ECD_Ly6D cd23542
extracellular domain (ECD) found in lymphocyte antigen 6D (Ly-6D) and similar proteins; Ly-6D ...
 48-140 2.02e-04

extracellular domain (ECD) found in lymphocyte antigen 6D (Ly-6D) and similar proteins; Ly-6D (also called E48 antigen) is a GPI-anchored molecule apparently involved in keratinocyte cell-cell adhesion. It may act as a specification marker at earliest stage specification of lymphocytes between B- and T-cell development. Ly-6D contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467072  Cd Length: 79  Bit Score: 38.16  E-value: 2.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034660265  48 PAHGLWCQDCTLTTNSSHctPKQCQPSDTVCASVRITDPSssrkDHSVNKMCASSCDFVKRhffsdylmgFINSGILKVD 127
Cdd:cd23542     2 PANALQCHVCNSSSNCTN--PVNCEGSERYCKTTTVVQPS----GNLVKKGCAETCPPSTS---------RQQVGSGISS 66

                          90
                  ....*....|...
gi 1034660265 128 VDCCEKDLCNGAA 140
Cdd:cd23542    67 VTCCQGDLCNSKL 79
TFP_LU_ECD_PSCA cd23573
extracellular domain (ECD) found in prostate stem cell antigen (PSCA) and similar proteins; ...
 52-137 6.64e-04

extracellular domain (ECD) found in prostate stem cell antigen (PSCA) and similar proteins; PSCA may be involved in the regulation of cell proliferation. It has a cell-proliferation inhibition activity in vitro. PSCA may also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro it inhibits nicotine-induced signaling probably implicating alpha-3:beta-2- or alpha-7-containing nAChRs. PSCA contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467103  Cd Length: 78  Bit Score: 36.65  E-value: 6.64e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034660265  52 LWCQDCTLTTNSSHC-TPKQCQPSDTVCASVRITDPSSSrkdHSVNKMCASSCDFVkrhfFSDYLMGFINsgilkvdVDC 130
Cdd:cd23573     3 LQCYTCKAQLSNSNCqTETPCRENAKACKTDVIRAVGLL---KVISKECSSSCTED----YQDYFVGKRN-------ITC 68


                  ....*..
gi 1034660265 131 CEKDLCN 137
Cdd:cd23573    69 CSTDLCN 75
TFP cd00117
three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU ...
 52-137 2.11e-03

three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU (also known as Ly-6 antigen/uPA receptor)-like extracellular domain (ECD) occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. It is a structural domain involved in protein-protein interactions, tolerating an unusual degree of variation and binding with high specificity to a broad spectrum of targets. The snake toxin domain is present in short and long neurotoxins, cytotoxins, and short toxins, and in other miscellaneous venom peptides. The toxin acts by binding to the nicotinic acetylcholine receptors in the postsynaptic membrane of skeletal muscles and preventing the binding of acetylcholine, thereby blocking the excitation of muscles. Both the LU-like ECD and the snake toxin domain belong to three-fingered protein (TFP) fold, which is characterized by containing 70 to 100 amino acids including eight to ten cysteine residues spaced at conserved distances.


Pssm-ID: 467060  Cd Length: 81  Bit Score: 35.54  E-value: 2.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034660265  52 LWCQDCTLTTNSSHC----TPKQCQPSDTVCASVRITDPSSSRkdhSVNKMCASSCDFVKRHFFSDYLMGFINSgilkvd 127
Cdd:cd00117     1 LKCYQCNSSNDPNCCnsspTLVTCSSPETFCRKIVGKVGGGET---LVIRGCATECECGCTECCSGTGTSGTTC------ 71

                          90
                  ....*....|
gi 1034660265 128 VDCCEKDLCN 137
Cdd:cd00117    72 TSCCDTDLCN 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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