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Conserved domains on  [gi|1038272236|gb|ANM45237|]
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hypothetical protein [Salmonella phage 146851_sal4]

Protein Classification

replicative DNA helicase( domain architecture ID 10466168)

replicative DNA helicase unwinds the DNA duplex at the chromosome replication fork

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DnaB COG0305
Replicative DNA helicase [Replication, recombination and repair];
4-427 6.93e-139

Replicative DNA helicase [Replication, recombination and repair];


:

Pssm-ID: 440074 [Multi-domain]  Cd Length: 429  Bit Score: 405.23  E-value: 6.93e-139
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236   4 DIEASVIGGLLiggLTPTA-SDVLATLEPEAFSIPLYRKAFEVIRKQARNRNLIDGLMVAEEC----------GDEYata 72
Cdd:COG0305     3 EAEQAVLGALL---LDNDAlDEVADILKPEDFYRPAHRLIFEAILDLYERGEPIDLVTVAEELekrgeleevgGAAY--- 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236  73 VMMTARSCPSAANLKGYAGMVADSYQRRQVLQLLDEMREPISNGTLDASgRAMDDLVKRLSAIRKPRDEVKPVRLGEIIN 152
Cdd:COG0305    77 LAELAENVPSAANIEYYARIVKEKALLRRLIEAGTEIVELAYDEDEDVD-ELLDEAEQKIFEIAEKRSSKGFVSISDILK 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 153 DYTDTLDRRLRNGEESDTLKTGIEELDAITGGMNAEDLVIIAARPGMGKTELALKIAEGVASRVipgsgvRRGVLIFSME 232
Cdd:COG0305   156 EALERIEELYKNGGGITGVPTGFTDLDKLTGGLQPGDLIILAARPSMGKTAFALNIARNAAIKE------GKPVAIFSLE 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 233 MSAIQVVERGIAGAGMMSVSVLRNPsRMDDEGWARVASGMKLLADLDVWVVDASRLSVEEIRSISERHKQEHpNLSLIMA 312
Cdd:COG0305   230 MSAEQLVMRLLSSEARIDSSKLRTG-KLSDEDWERLSSAAGELSEAPIYIDDTPGLTIAEIRAKARRLKREH-GLGLIVI 307

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 313 DYLGLIEKP-KAERNDLAIAHISGSLKAMAKDLKTPVISLSQLSRDVEKRPNKRPTNADLRDSGSIEQDADSIIMLYREA 391
Cdd:COG0305   308 DYLQLMSGSgRSENRQQEISEISRSLKALAKELNVPVIALSQLSRAVEQRTDKRPQLSDLRESGSIEQDADVVMFLYRDE 387

                         410       420       430
                  ....*....|....*....|....*....|....*.
gi 1038272236 392 VYDENSSAAPFAEIIVTKNRFGSLGTVYQRFcNGHF 427
Cdd:COG0305   388 YYNPDSEDKGIAEIIIAKQRNGPTGTVKLAF-DGEY 422
 
Name Accession Description Interval E-value
DnaB COG0305
Replicative DNA helicase [Replication, recombination and repair];
4-427 6.93e-139

Replicative DNA helicase [Replication, recombination and repair];


Pssm-ID: 440074 [Multi-domain]  Cd Length: 429  Bit Score: 405.23  E-value: 6.93e-139
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236   4 DIEASVIGGLLiggLTPTA-SDVLATLEPEAFSIPLYRKAFEVIRKQARNRNLIDGLMVAEEC----------GDEYata 72
Cdd:COG0305     3 EAEQAVLGALL---LDNDAlDEVADILKPEDFYRPAHRLIFEAILDLYERGEPIDLVTVAEELekrgeleevgGAAY--- 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236  73 VMMTARSCPSAANLKGYAGMVADSYQRRQVLQLLDEMREPISNGTLDASgRAMDDLVKRLSAIRKPRDEVKPVRLGEIIN 152
Cdd:COG0305    77 LAELAENVPSAANIEYYARIVKEKALLRRLIEAGTEIVELAYDEDEDVD-ELLDEAEQKIFEIAEKRSSKGFVSISDILK 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 153 DYTDTLDRRLRNGEESDTLKTGIEELDAITGGMNAEDLVIIAARPGMGKTELALKIAEGVASRVipgsgvRRGVLIFSME 232
Cdd:COG0305   156 EALERIEELYKNGGGITGVPTGFTDLDKLTGGLQPGDLIILAARPSMGKTAFALNIARNAAIKE------GKPVAIFSLE 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 233 MSAIQVVERGIAGAGMMSVSVLRNPsRMDDEGWARVASGMKLLADLDVWVVDASRLSVEEIRSISERHKQEHpNLSLIMA 312
Cdd:COG0305   230 MSAEQLVMRLLSSEARIDSSKLRTG-KLSDEDWERLSSAAGELSEAPIYIDDTPGLTIAEIRAKARRLKREH-GLGLIVI 307

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 313 DYLGLIEKP-KAERNDLAIAHISGSLKAMAKDLKTPVISLSQLSRDVEKRPNKRPTNADLRDSGSIEQDADSIIMLYREA 391
Cdd:COG0305   308 DYLQLMSGSgRSENRQQEISEISRSLKALAKELNVPVIALSQLSRAVEQRTDKRPQLSDLRESGSIEQDADVVMFLYRDE 387

                         410       420       430
                  ....*....|....*....|....*....|....*.
gi 1038272236 392 VYDENSSAAPFAEIIVTKNRFGSLGTVYQRFcNGHF 427
Cdd:COG0305   388 YYNPDSEDKGIAEIIIAKQRNGPTGTVKLAF-DGEY 422
DnaB_C cd00984
C-terminal domain of DnaB helicase; DnaB helicase C-terminal domain. The hexameric helicase ...
 171-431 2.16e-120

C-terminal domain of DnaB helicase; DnaB helicase C-terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a change in the quaternary structure of the protein involving dimerization of the N-terminal domain has been observed and may occur during the enzymatic cycle. This C-terminal domain contains an ATP-binding site and is therefore probably the site of ATP hydrolysis.


Pssm-ID: 410864 [Multi-domain]  Cd Length: 256  Bit Score: 351.81  E-value: 2.16e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 171 LKTGIEELDAITGGMNAEDLVIIAARPGMGKTELALKIAEGVASRVipgsgvRRGVLIFSMEMSAIQVVERGIAGAGMMS 250
Cdd:cd00984     2 LPTGFTDLDKLTGGLQPGDLIIIAARPSMGKTAFALNIAENIALDE------GLPVLFFSLEMSAEQLAERLLSSESGVS 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 251 VSVLRNPSRMDDEgWARVASGMKLLADLDVWVVDASRLSVEEIRSISERHKQEHPNLSLIMADYLGLIEKPK-AERNDLA 329
Cdd:cd00984    76 LSKLRTGRLDDED-WERLTAAMGELSELPLYIDDTPGLTVDEIRAKARRLKREHGGLGLIVIDYLQLIRGSKrAENRQQE 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 330 IAHISGSLKAMAKDLKTPVISLSQLSRDVEKRPNKRPTNADLRDSGSIEQDADSIIMLYREAVYDENSSAAPFAEIIVTK 409
Cdd:cd00984   155 VAEISRSLKALAKELNVPVIALSQLNRGVESRTDKRPMLSDLRESGSIEQDADVVIFLYRDEYYDKDSEDKGIAEIIIAK 234

                         250       260
                  ....*....|....*....|..
gi 1038272236 410 NRFGSLGTVYQRFCNGHFVACD 431
Cdd:cd00984   235 NRNGPTGTVYLAFNPEYTRFTD 256
DnaB TIGR00665
replicative DNA helicase; This model describes the helicase DnaB, a homohexameric protein ...
 3-427 8.59e-112

replicative DNA helicase; This model describes the helicase DnaB, a homohexameric protein required for DNA replication. The homohexamer can form a ring around a single strand of DNA near a replication fork. An intein of > 400 residues is found at a conserved location in DnaB of Synechocystis PCC6803, Rhodothermus marinus (both experimentally confirmed), and Mycobacterium tuberculosis. The intein removes itself by a self-splicing reaction. The seed alignment contains inteins so that the model built from the seed alignment will model a low cost at common intein insertion sites. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273206 [Multi-domain]  Cd Length: 432  Bit Score: 336.32  E-value: 8.59e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236   3 QDIEA--SVIGGLLiggLTPTA-SDVLATLEPEAFSIPLYRKAFEVIRKQARNRNLIDGLMVAEEC----------GDEY 69
Cdd:TIGR00665   3 HNIEAeqAVLGAIL---LDNEAiDDVAEILKPEDFYRPAHRLIFQAILDLYEKGEPIDLVTVAEELekdgeleevgGLAY 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236  70 ATAVMMTArscPSAANLKGYAGMVADSYQRRQVLQLLDEMREPISNGTLDASGrAMDDLVKRLSAIRKPRDEVKPVRLGE 149
Cdd:TIGR00665  80 LAELASNV---PSAANIEYYAEIVKEKAILRRLIQAGTEIVELAYDPTGDVEE-LLDEAEQKIFEIAESRTSKGFKSIKE 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 150 IINDYTDTLDRRLRNGEESDTLKTGIEELDAITGGMNAEDLVIIAARPGMGKTELALKIAEGVASRVipgsgvRRGVLIF 229
Cdd:TIGR00665 156 ILKEAVEEIEELYERKGGITGVPTGFTDLDKLTSGLQPSDLIILAARPSMGKTAFALNIAENAAIKE------GKPVAFF 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 230 SMEMSAIQVVERGIAGAGMMSVSVLRNPsRMDDEGWARVASGMKLLADLDVWVVDASRLSVEEIRSISERHKQEHpNLSL 309
Cdd:TIGR00665 230 SLEMSAEQLVMRMLSSESRVDSQKLRTG-RLSDEDWEKLTEAAGELSEAPLYIDDTPGLTITELRAKARRLKREH-GLGL 307

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 310 IMADYLGLIEKPKAERN-DLAIAHISGSLKAMAKDLKTPVISLSQLSRDVEKRPNKRPTNADLRDSGSIEQDADSIIMLY 388
Cdd:TIGR00665 308 IVIDYLQLMSGSGRSENrQQEVSEISRSLKALAKELNVPVIALSQLSRSVEQREDKRPQLSDLRESGSIEQDADIVMFLY 387

                         410       420       430
                  ....*....|....*....|....*....|....*....
gi 1038272236 389 REAVYDENSSAAPFAEIIVTKNRFGSLGTVYQRFcNGHF 427
Cdd:TIGR00665 388 RDEYYNPDSEDKGIAEIIIAKQRNGPTGTVKLAF-LGEY 425
DnaB_C pfam03796
DnaB-like helicase C terminal domain; The hexameric helicase DnaB unwinds the DNA duplex at ...
 171-424 3.04e-96

DnaB-like helicase C terminal domain; The hexameric helicase DnaB unwinds the DNA duplex at the Escherichia coli chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a change in the quaternary structure of the protein involving dimerization of the N-terminal domain has been observed and may occur during the enzymatic cycle. This C-terminal domain contains an ATP-binding site and is therefore probably the site of ATP hydrolysis.


Pssm-ID: 427509 [Multi-domain]  Cd Length: 254  Bit Score: 290.09  E-value: 3.04e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 171 LKTGIEELDAITGGMNAEDLVIIAARPGMGKTELALKIAEGVASRVipgsgvRRGVLIFSMEMSAIQVVERGIAGAGMMS 250
Cdd:pfam03796   2 LPTGFTDLDRLTGGLQPGDLIIIAARPSMGKTAFALNIARNAAVKH------KKPVAIFSLEMSAEQLVMRLLASEAGVD 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 251 VSVLRNPsRMDDEGWARVASGMKLLADLDVWVVDASRLSVEEIRSISERHKQEHpNLSLIMADYLGLIEKPKAERN-DLA 329
Cdd:pfam03796  76 SQKLRTG-QLTDEDWEKLAKAAGRLSEAPLYIDDTPGLSIAEIRAKARRLKREH-GLGLIVIDYLQLMSGGSRGENrQQE 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 330 IAHISGSLKAMAKDLKTPVISLSQLSRDVEKRPNKRPTNADLRDSGSIEQDADSIIMLYREAVYDENSSAAPfAEIIVTK 409
Cdd:pfam03796 154 ISEISRSLKALAKELNVPVIALSQLSRAVEQRTDKRPQLSDLRESGAIEQDADVVMFLYRDEYYNPKEPEGK-AEIIIAK 232

                         250       260
                  ....*....|....*....|..
gi 1038272236 410 NRFGSLGTV-------YQRFCN 424
Cdd:pfam03796 233 QRNGPTGTVklaflgeYTRFEN 254
PRK05748 PRK05748
replicative DNA helicase; Provisional
 3-424 1.46e-93

replicative DNA helicase; Provisional


Pssm-ID: 180232 [Multi-domain]  Cd Length: 448  Bit Score: 289.93  E-value: 1.46e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236   3 QDIEA--SVIGGLLiggLTPTASD-VLATLEPEAFSIPLYRKAFEVIRKQARNRNLIDGLMVAEECGDE----------Y 69
Cdd:PRK05748   12 QSIEAeqAVLGAIF---LDPDALItVSEYLSPDDFYRHAHRLIFRAMLKLSDRGEPIDVVTVTEILDDQgdleevgglsY 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236  70 ATAVmmtARSCPSAANLKGYAGMVADSYQRRQVLQLLDEMREPISNGTlDASGRAMDDLVKRLSAIRKPRDEVKPVRLGE 149
Cdd:PRK05748   89 LAEL---ANSVPTAANIEYYAKIVAEKAMLRRLIRTATEIANDAYEPE-DDADEILDEAEKKIFEVSERRNKSGFKNIKD 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 150 IINDYTDTLDRRLRNGEESDTLKTGIEELDAITGGMNAEDLVIIAARPGMGKTELALKIAEGVASRVipgsgvRRGVLIF 229
Cdd:PRK05748  165 VLVKAYDRIEMLHNQTGDITGIPTGFTDLDKMTSGLQPNDLIIVAARPSVGKTAFALNIAQNVATKT------DKNVAIF 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 230 SMEMSAIQVVERGIAGAGMMSVSVLRNpSRMDDEGWARVASGMKLLADLDVWVVDASRLSVEEIRSISERHKQEHPNLSL 309
Cdd:PRK05748  239 SLEMGAESLVMRMLCAEGNIDAQRLRT-GQLTDDDWPKLTIAMGSLSDAPIYIDDTPGIKVTEIRARCRRLAQEHGGLGL 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 310 IMADYLGLIE--KPKAERNDLAIAHISGSLKAMAKDLKTPVISLSQLSRDVEKRPNKRPTNADLRDSGSIEQDADSIIML 387
Cdd:PRK05748  318 ILIDYLQLIQgsGRSGENRQQEVSEISRSLKALAKELKVPVIALSQLSRGVEQRQDKRPVMSDIRESGSIEQDADIVAFL 397

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....
gi 1038272236 388 YREAVYDENSSAAPFAEIIVTKNRFGSLGTV-------YQRFCN 424
Cdd:PRK05748  398 YRDDYYDEETENKNTIEIIIAKQRNGPVGTVelafqkeYNKFVN 441
 
Name Accession Description Interval E-value
DnaB COG0305
Replicative DNA helicase [Replication, recombination and repair];
4-427 6.93e-139

Replicative DNA helicase [Replication, recombination and repair];


Pssm-ID: 440074 [Multi-domain]  Cd Length: 429  Bit Score: 405.23  E-value: 6.93e-139
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236   4 DIEASVIGGLLiggLTPTA-SDVLATLEPEAFSIPLYRKAFEVIRKQARNRNLIDGLMVAEEC----------GDEYata 72
Cdd:COG0305     3 EAEQAVLGALL---LDNDAlDEVADILKPEDFYRPAHRLIFEAILDLYERGEPIDLVTVAEELekrgeleevgGAAY--- 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236  73 VMMTARSCPSAANLKGYAGMVADSYQRRQVLQLLDEMREPISNGTLDASgRAMDDLVKRLSAIRKPRDEVKPVRLGEIIN 152
Cdd:COG0305    77 LAELAENVPSAANIEYYARIVKEKALLRRLIEAGTEIVELAYDEDEDVD-ELLDEAEQKIFEIAEKRSSKGFVSISDILK 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 153 DYTDTLDRRLRNGEESDTLKTGIEELDAITGGMNAEDLVIIAARPGMGKTELALKIAEGVASRVipgsgvRRGVLIFSME 232
Cdd:COG0305   156 EALERIEELYKNGGGITGVPTGFTDLDKLTGGLQPGDLIILAARPSMGKTAFALNIARNAAIKE------GKPVAIFSLE 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 233 MSAIQVVERGIAGAGMMSVSVLRNPsRMDDEGWARVASGMKLLADLDVWVVDASRLSVEEIRSISERHKQEHpNLSLIMA 312
Cdd:COG0305   230 MSAEQLVMRLLSSEARIDSSKLRTG-KLSDEDWERLSSAAGELSEAPIYIDDTPGLTIAEIRAKARRLKREH-GLGLIVI 307

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 313 DYLGLIEKP-KAERNDLAIAHISGSLKAMAKDLKTPVISLSQLSRDVEKRPNKRPTNADLRDSGSIEQDADSIIMLYREA 391
Cdd:COG0305   308 DYLQLMSGSgRSENRQQEISEISRSLKALAKELNVPVIALSQLSRAVEQRTDKRPQLSDLRESGSIEQDADVVMFLYRDE 387

                         410       420       430
                  ....*....|....*....|....*....|....*.
gi 1038272236 392 VYDENSSAAPFAEIIVTKNRFGSLGTVYQRFcNGHF 427
Cdd:COG0305   388 YYNPDSEDKGIAEIIIAKQRNGPTGTVKLAF-DGEY 422
DnaB_C cd00984
C-terminal domain of DnaB helicase; DnaB helicase C-terminal domain. The hexameric helicase ...
 171-431 2.16e-120

C-terminal domain of DnaB helicase; DnaB helicase C-terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a change in the quaternary structure of the protein involving dimerization of the N-terminal domain has been observed and may occur during the enzymatic cycle. This C-terminal domain contains an ATP-binding site and is therefore probably the site of ATP hydrolysis.


Pssm-ID: 410864 [Multi-domain]  Cd Length: 256  Bit Score: 351.81  E-value: 2.16e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 171 LKTGIEELDAITGGMNAEDLVIIAARPGMGKTELALKIAEGVASRVipgsgvRRGVLIFSMEMSAIQVVERGIAGAGMMS 250
Cdd:cd00984     2 LPTGFTDLDKLTGGLQPGDLIIIAARPSMGKTAFALNIAENIALDE------GLPVLFFSLEMSAEQLAERLLSSESGVS 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 251 VSVLRNPSRMDDEgWARVASGMKLLADLDVWVVDASRLSVEEIRSISERHKQEHPNLSLIMADYLGLIEKPK-AERNDLA 329
Cdd:cd00984    76 LSKLRTGRLDDED-WERLTAAMGELSELPLYIDDTPGLTVDEIRAKARRLKREHGGLGLIVIDYLQLIRGSKrAENRQQE 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 330 IAHISGSLKAMAKDLKTPVISLSQLSRDVEKRPNKRPTNADLRDSGSIEQDADSIIMLYREAVYDENSSAAPFAEIIVTK 409
Cdd:cd00984   155 VAEISRSLKALAKELNVPVIALSQLNRGVESRTDKRPMLSDLRESGSIEQDADVVIFLYRDEYYDKDSEDKGIAEIIIAK 234

                         250       260
                  ....*....|....*....|..
gi 1038272236 410 NRFGSLGTVYQRFCNGHFVACD 431
Cdd:cd00984   235 NRNGPTGTVYLAFNPEYTRFTD 256
DnaB TIGR00665
replicative DNA helicase; This model describes the helicase DnaB, a homohexameric protein ...
 3-427 8.59e-112

replicative DNA helicase; This model describes the helicase DnaB, a homohexameric protein required for DNA replication. The homohexamer can form a ring around a single strand of DNA near a replication fork. An intein of > 400 residues is found at a conserved location in DnaB of Synechocystis PCC6803, Rhodothermus marinus (both experimentally confirmed), and Mycobacterium tuberculosis. The intein removes itself by a self-splicing reaction. The seed alignment contains inteins so that the model built from the seed alignment will model a low cost at common intein insertion sites. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273206 [Multi-domain]  Cd Length: 432  Bit Score: 336.32  E-value: 8.59e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236   3 QDIEA--SVIGGLLiggLTPTA-SDVLATLEPEAFSIPLYRKAFEVIRKQARNRNLIDGLMVAEEC----------GDEY 69
Cdd:TIGR00665   3 HNIEAeqAVLGAIL---LDNEAiDDVAEILKPEDFYRPAHRLIFQAILDLYEKGEPIDLVTVAEELekdgeleevgGLAY 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236  70 ATAVMMTArscPSAANLKGYAGMVADSYQRRQVLQLLDEMREPISNGTLDASGrAMDDLVKRLSAIRKPRDEVKPVRLGE 149
Cdd:TIGR00665  80 LAELASNV---PSAANIEYYAEIVKEKAILRRLIQAGTEIVELAYDPTGDVEE-LLDEAEQKIFEIAESRTSKGFKSIKE 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 150 IINDYTDTLDRRLRNGEESDTLKTGIEELDAITGGMNAEDLVIIAARPGMGKTELALKIAEGVASRVipgsgvRRGVLIF 229
Cdd:TIGR00665 156 ILKEAVEEIEELYERKGGITGVPTGFTDLDKLTSGLQPSDLIILAARPSMGKTAFALNIAENAAIKE------GKPVAFF 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 230 SMEMSAIQVVERGIAGAGMMSVSVLRNPsRMDDEGWARVASGMKLLADLDVWVVDASRLSVEEIRSISERHKQEHpNLSL 309
Cdd:TIGR00665 230 SLEMSAEQLVMRMLSSESRVDSQKLRTG-RLSDEDWEKLTEAAGELSEAPLYIDDTPGLTITELRAKARRLKREH-GLGL 307

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 310 IMADYLGLIEKPKAERN-DLAIAHISGSLKAMAKDLKTPVISLSQLSRDVEKRPNKRPTNADLRDSGSIEQDADSIIMLY 388
Cdd:TIGR00665 308 IVIDYLQLMSGSGRSENrQQEVSEISRSLKALAKELNVPVIALSQLSRSVEQREDKRPQLSDLRESGSIEQDADIVMFLY 387

                         410       420       430
                  ....*....|....*....|....*....|....*....
gi 1038272236 389 REAVYDENSSAAPFAEIIVTKNRFGSLGTVYQRFcNGHF 427
Cdd:TIGR00665 388 RDEYYNPDSEDKGIAEIIIAKQRNGPTGTVKLAF-LGEY 425
DnaB_C pfam03796
DnaB-like helicase C terminal domain; The hexameric helicase DnaB unwinds the DNA duplex at ...
 171-424 3.04e-96

DnaB-like helicase C terminal domain; The hexameric helicase DnaB unwinds the DNA duplex at the Escherichia coli chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a change in the quaternary structure of the protein involving dimerization of the N-terminal domain has been observed and may occur during the enzymatic cycle. This C-terminal domain contains an ATP-binding site and is therefore probably the site of ATP hydrolysis.


Pssm-ID: 427509 [Multi-domain]  Cd Length: 254  Bit Score: 290.09  E-value: 3.04e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 171 LKTGIEELDAITGGMNAEDLVIIAARPGMGKTELALKIAEGVASRVipgsgvRRGVLIFSMEMSAIQVVERGIAGAGMMS 250
Cdd:pfam03796   2 LPTGFTDLDRLTGGLQPGDLIIIAARPSMGKTAFALNIARNAAVKH------KKPVAIFSLEMSAEQLVMRLLASEAGVD 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 251 VSVLRNPsRMDDEGWARVASGMKLLADLDVWVVDASRLSVEEIRSISERHKQEHpNLSLIMADYLGLIEKPKAERN-DLA 329
Cdd:pfam03796  76 SQKLRTG-QLTDEDWEKLAKAAGRLSEAPLYIDDTPGLSIAEIRAKARRLKREH-GLGLIVIDYLQLMSGGSRGENrQQE 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 330 IAHISGSLKAMAKDLKTPVISLSQLSRDVEKRPNKRPTNADLRDSGSIEQDADSIIMLYREAVYDENSSAAPfAEIIVTK 409
Cdd:pfam03796 154 ISEISRSLKALAKELNVPVIALSQLSRAVEQRTDKRPQLSDLRESGAIEQDADVVMFLYRDEYYNPKEPEGK-AEIIIAK 232

                         250       260
                  ....*....|....*....|..
gi 1038272236 410 NRFGSLGTV-------YQRFCN 424
Cdd:pfam03796 233 QRNGPTGTVklaflgeYTRFEN 254
PRK05748 PRK05748
replicative DNA helicase; Provisional
 3-424 1.46e-93

replicative DNA helicase; Provisional


Pssm-ID: 180232 [Multi-domain]  Cd Length: 448  Bit Score: 289.93  E-value: 1.46e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236   3 QDIEA--SVIGGLLiggLTPTASD-VLATLEPEAFSIPLYRKAFEVIRKQARNRNLIDGLMVAEECGDE----------Y 69
Cdd:PRK05748   12 QSIEAeqAVLGAIF---LDPDALItVSEYLSPDDFYRHAHRLIFRAMLKLSDRGEPIDVVTVTEILDDQgdleevgglsY 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236  70 ATAVmmtARSCPSAANLKGYAGMVADSYQRRQVLQLLDEMREPISNGTlDASGRAMDDLVKRLSAIRKPRDEVKPVRLGE 149
Cdd:PRK05748   89 LAEL---ANSVPTAANIEYYAKIVAEKAMLRRLIRTATEIANDAYEPE-DDADEILDEAEKKIFEVSERRNKSGFKNIKD 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 150 IINDYTDTLDRRLRNGEESDTLKTGIEELDAITGGMNAEDLVIIAARPGMGKTELALKIAEGVASRVipgsgvRRGVLIF 229
Cdd:PRK05748  165 VLVKAYDRIEMLHNQTGDITGIPTGFTDLDKMTSGLQPNDLIIVAARPSVGKTAFALNIAQNVATKT------DKNVAIF 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 230 SMEMSAIQVVERGIAGAGMMSVSVLRNpSRMDDEGWARVASGMKLLADLDVWVVDASRLSVEEIRSISERHKQEHPNLSL 309
Cdd:PRK05748  239 SLEMGAESLVMRMLCAEGNIDAQRLRT-GQLTDDDWPKLTIAMGSLSDAPIYIDDTPGIKVTEIRARCRRLAQEHGGLGL 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 310 IMADYLGLIE--KPKAERNDLAIAHISGSLKAMAKDLKTPVISLSQLSRDVEKRPNKRPTNADLRDSGSIEQDADSIIML 387
Cdd:PRK05748  318 ILIDYLQLIQgsGRSGENRQQEVSEISRSLKALAKELKVPVIALSQLSRGVEQRQDKRPVMSDIRESGSIEQDADIVAFL 397

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....
gi 1038272236 388 YREAVYDENSSAAPFAEIIVTKNRFGSLGTV-------YQRFCN 424
Cdd:PRK05748  398 YRDDYYDEETENKNTIEIIIAKQRNGPVGTVelafqkeYNKFVN 441
phage_DnaB TIGR03600
phage replicative helicase, DnaB family, HK022 subfamily; Members of this family are phage (or ...
 4-419 7.25e-89

phage replicative helicase, DnaB family, HK022 subfamily; Members of this family are phage (or prophage-region) homologs of the bacterial homohexameric replicative helicase DnaB. Some phage may rely on host DnaB, while others encode their own verions. This model describes the largest phage-specific clade among the close homologs of DnaB, but there are, or course, other DnaB homologs from phage that fall outside the scope of this model. [Mobile and extrachromosomal element functions, Prophage functions]


Pssm-ID: 274672 [Multi-domain]  Cd Length: 420  Bit Score: 276.98  E-value: 7.25e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236   4 DIEASVIGGLLIgglTPTASD-VLATLEPEAFSIPLYRKAFEVIRKQARNRNLIDGLMVAEE----------CGDEYATA 72
Cdd:TIGR03600   3 EAEQAVLGGLLL---DNDFIErVMAILKPEHFYSQDHRIIFEAMLDMFAENRPVDPLTLADKleaegeaekvGGLAYLAE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236  73 VMmtaRSCPSAANLKGYAGMVADSYQRRQVLQLLDEmrepISNGTLDASGRAMDDLVKRLSAI-----RKPRDEVKPVRL 147
Cdd:TIGR03600  80 IS---NNTPSAANISSYARIVREKAKERKLIAACQR----IITLACSPDGGTAEQKVEEAQAAllaltMSDGQEDGFVTF 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 148 GEIINDYTDTLDRRLRNGEESDTLKTGIEELDAITGGMNAEDLVIIAARPGMGKTELALKIAEGVAsrvipgsgVRRG-- 225
Cdd:TIGR03600 153 GEVLEDVVRDLDKRFNPKGELTGLSTGLPKLDRLTNGLVKGDLIVIGARPSMGKTTLALNIAENVA--------LREGkp 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 226 VLIFSMEMSAIQVVERGIAGAGMMSVSVLRNPSRMDDEgWARVASGMKLLADLDVWVVDASRLSVEEIRSISERHKQEHP 305
Cdd:TIGR03600 225 VLFFSLEMSAEQLGERLLASKSGINTGNIRTGRFNDSE-FNRLLNAVDRLSEKDLYIDDTGGLTVAQIRSIARRIKRKKG 303

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 306 NLSLIMADYLGLIEKP-KAERNdLAIAHISGSLKAMAKDLKTPVISLSQLSRDVEKRPNKRPTNADLRDSGSIEQDADSI 384
Cdd:TIGR03600 304 GLDLIVVDYIQLMAPArGRDRN-EELGGISRGLKALAKELDVPVVLLAQLNRGSEKRTDKRPIMSDLRDSGAIEQDADVI 382

                         410       420       430
                  ....*....|....*....|....*....|....*
gi 1038272236 385 IMLYREAVYDENSSAAPFAEIIVTKNRFGSLGTVY 419
Cdd:TIGR03600 383 GLIHREGYYDAREPPAGIAELILAKNRHGPTGTVE 417
PRK08760 PRK08760
replicative DNA helicase; Provisional
 6-426 1.56e-76

replicative DNA helicase; Provisional


Pssm-ID: 181547 [Multi-domain]  Cd Length: 476  Bit Score: 246.75  E-value: 1.56e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236   6 EASVIGGLLiggLTPTASDVLA-TLEPEAFSIPLYRKAFEVIRKQARNRNLIDGLMVAE--------ECGDEYATAVMMt 76
Cdd:PRK08760   40 EQAVLGGLM---LAPDALDRVNdQLTENDFYRRDHRLIYRAIRELSEKDRPFDAVTLGEwfesqgklEQVGDGAYLIEL- 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236  77 ARSCPSAANLKGYAGMVADsyqrRQVLQLLDEMREPISNGTLDASGRAMDDLV----KRLSAIRKP--RDEVKPVRLGEI 150
Cdd:PRK08760  116 ASTTPSAANIAAYAEIVRD----KAVLRQLIEVGTTIVNDGFQPEGRESIELLasaeKAVFKIAEAgaRGRTDFVAMPGA 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 151 INDYTDTLDRRLRNGEESDTLKTGIEELDAITGGMNAEDLVIIAARPGMGKTELALKIAEGVASRVipgsgvRRGVLIFS 230
Cdd:PRK08760  192 LKDAFEELRNRFENGGNITGLPTGYNDFDAMTAGLQPTDLIILAARPAMGKTTFALNIAEYAAIKS------KKGVAVFS 265

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 231 MEMSAIQVVERGIAGAGMMSVSVLRNpSRMDDEGWARVASGMKLLADLDVWVVDASRLSVEEIRSISERHKQEHpNLSLI 310
Cdd:PRK08760  266 MEMSASQLAMRLISSNGRINAQRLRT-GALEDEDWARVTGAIKMLKETKIFIDDTPGVSPEVLRSKCRRLKREH-DLGLI 343

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 311 MADYLGLIEKP-KAERNDLAIAHISGSLKAMAKDLKTPVISLSQLSRDVEKRPNKRPTNADLRDSGSIEQDADSIIMLYR 389
Cdd:PRK08760  344 VIDYLQLMSVPgNSENRATEISEISRSLKGLAKELNVPVIALSQLNRSLETRTDKRPVMADLRESGAIEQDADMIVFIYR 423

                         410       420       430
                  ....*....|....*....|....*....|....*...
gi 1038272236 390 EAVYD-ENSSAAPFAEIIVTKNRFGSLGTVYQRFCNGH 426
Cdd:PRK08760  424 DDYYNkENSPDKGLAEIIIGKHRGGPTGSCKLKFFGEY 461
PRK08006 PRK08006
replicative DNA helicase DnaB;
6-427 3.08e-74

replicative DNA helicase DnaB;


Pssm-ID: 181193 [Multi-domain]  Cd Length: 471  Bit Score: 240.68  E-value: 3.08e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236   6 EASVIGGLLIGglTPTASDVLATLEPEAFSIPLYRKAFEVIRKQARNRNLIDGLMVAEEC----------GDEYATAVmm 75
Cdd:PRK08006   34 EQSVLGGLMLD--NERWDDVAERVVADDFYTRPHRHIFTEMARLQESGSPIDLITLAESLerqgqldsvgGFAYLAEL-- 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236  76 tARSCPSAANLKGYAGMVADSYQRRQVLQLLDEmrepISNGTLDASGRAMDDL-------VKRLSAIRKPRDEvKPVRLG 148
Cdd:PRK08006  110 -SKNTPSAANISAYADIVRERAVVREMISVANE----IADAGYDPQGRTSEDLldlaesrVFQIAESRANKDE-GPKNIA 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 149 EIINDYTDTLDRRLRNGEESDT-LKTGIEELDAITGGMNAEDLVIIAARPGMGKTELALKIAEGVASRVipgsgvRRGVL 227
Cdd:PRK08006  184 DILDATVARIEQLFQQPHDGVTgVNTGYDDLNKKTAGLQPSDLIIVAARPSMGKTTFAMNLCENAAMLQ------DKPVL 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 228 IFSMEMSAIQVVERGIAGAGMMSVSVLRNpSRMDDEGWARVASGMK-LLADLDVWVVDASRLSVEEIRSISERHKQEHPN 306
Cdd:PRK08006  258 IFSLEMPGEQIMMRMLASLSRVDQTRIRT-GQLDDEDWARISGTMGiLLEKRNMYIDDSSGLTPTEVRSRARRIFREHGG 336

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 307 LSLIMADYLGLIEKPKAERN-DLAIAHISGSLKAMAKDLKTPVISLSQLSRDVEKRPNKRPTNADLRDSGSIEQDADSII 385
Cdd:PRK08006  337 LSLIMIDYLQLMRVPSLSDNrTLEIAEISRSLKALAKELQVPVVALSQLNRSLEQRADKRPVNSDLRESGSIEQDADLIM 416

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|..
gi 1038272236 386 MLYREAVYDENSSAAPFAEIIVTKNRFGSLGTVYQRFcNGHF 427
Cdd:PRK08006  417 FIYRDEVYHENSDLKGIAEIIIGKQRNGPIGTVRLTF-NGQW 457
PRK08506 PRK08506
replicative DNA helicase; Provisional
 3-422 3.58e-74

replicative DNA helicase; Provisional


Pssm-ID: 236278 [Multi-domain]  Cd Length: 472  Bit Score: 240.68  E-value: 3.58e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236   3 QDIEASVIGGLLiggLTPTA-SDVLATLEPEAFSIPLYRKAFEVIRKQARNRNLIDGLMVAEECGDE--YATAVMMTARS 79
Cdd:PRK08506    7 LDIERAVLSSIL---FSPDKfEEIASVLEPKDFYLPAHQDIFEAMLKLHNEDEPIDEEFIRKKLPKDkkIDEEILLEILA 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236  80 CPSAANLKGYAGMVADSYQRRQVLQLLDEMREPISNGTLdASGRAMDDLVKRLSAI--RKPRDEVKPVRlgEIINDYTDT 157
Cdd:PRK08506   84 TNPIDNIEAYVEEIKEKSIKRELLSLANTIPEQAVEEDQ-KSSDILDEVERELYSItnGSNSEDFKDSK--EVIESTMEH 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 158 LdRRLRNGEESDT--LKTGIEELDAITGGMNAEDLVIIAARPGMGKTELALKIAEGVASRvipgsgvRRGVLIFSMEMSA 235
Cdd:PRK08506  161 I-KKQKRLGNKDIigLDTGFVELNKMTKGFNKGDLIIIAARPSMGKTTLCLNMALKALNQ-------DKGVAFFSLEMPA 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 236 IQVVERGIAGAGMMSVSVLRNpSRMDDEGWARVASGMKLLADLDVWVVDASRLSVEEIRSISERHKQEHPNLSLIMADYL 315
Cdd:PRK08506  233 EQLMLRMLSAKTSIPLQNLRT-GDLDDDEWERLSDACDELSKKKLFVYDSGYVNIHQVRAQLRKLKSQHPEIGLAVIDYL 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 316 GLIEKPKAERN-DLAIAHISGSLKAMAKDLKTPVISLSQLSRDVEKRPNKRPTNADLRDSGSIEQDADSIIMLYREAVY- 393
Cdd:PRK08506  312 QLMSGSGNFKDrHLQISEISRGLKLLARELDIPIIALSQLNRSLESRADKRPMLSDLRESGAIEQDADIILFVYRDDVYk 391

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|
gi 1038272236 394 --DENSSAA------------PF-------AEIIVTKNRFGSLGTVYQRF 422
Cdd:PRK08506  392 erEEKEKEKkakkegkeerriHFqnksieeAEIIIGKNRNGPTGTVKLRF 441
PRK08840 PRK08840
replicative DNA helicase; Provisional
 6-424 3.31e-72

replicative DNA helicase; Provisional


Pssm-ID: 181562 [Multi-domain]  Cd Length: 464  Bit Score: 235.27  E-value: 3.31e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236   6 EASVIGGLLIGG--LTPTASDVLATlepEAFSIPlYRKAFEVIR---KQARNRNLI---DGLMVAEECGDEYATAVMMT- 76
Cdd:PRK08840   27 EQSVIGGLLLDNerWDTVAEKVVAS---DFYSRP-HRLIFEGVKsilEAGKPLDLItlsEHLERREQLEDVGGFAYLADl 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236  77 ARSCPSAANLKGYAGMVADSYQRRQVLQLLDEmrepISNGTLDASGRAMDDLV----KRLSAIRKPR--DEVKPVRLGEI 150
Cdd:PRK08840  103 AKNTPSAANINAYADIVAERALVRNLIGVANE----IADAGYDPQGRTSEDLLdmaeSKVFAIAEARtsENEGPQNVDSI 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 151 INDYTDTLDRRLRNGEESDT-LKTGIEELDAITGGMNAEDLVIIAARPGMGKTELALKIAEGVASRVipgsgvRRGVLIF 229
Cdd:PRK08840  179 LEKTLERIELLYKTPQDGVTgVDTGFTDLNKKTAGLQGSDLIIVAARPSMGKTTFAMNLCENAAMDQ------DKPVLIF 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 230 SMEMSAIQVVERGIAGAGMMSVSVLRNpSRMDDEGWARVASGMKLLADL-DVWVVDASRLSVEEIRSISERHKQEHPNLS 308
Cdd:PRK08840  253 SLEMPAEQLMMRMLASLSRVDQTKIRT-GQLDDEDWARISSTMGILMEKkNMYIDDSSGLTPTEVRSRARRIAREHGGLS 331

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 309 LIMADYLGLIEKPKAERN-DLAIAHISGSLKAMAKDLKTPVISLSQLSRDVEKRPNKRPTNADLRDSGSIEQDADSIIML 387
Cdd:PRK08840  332 MIMVDYLQLMRVPALSDNrTLEIAEISRSLKALAKELNVPVVALSQLNRSLEQRADKRPVNSDLRESGSIEQDADLIMFI 411

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....
gi 1038272236 388 YREAVYDENSSAAPFAEIIVTKNRFGSLGTV-------YQRFCN 424
Cdd:PRK08840  412 YRDEVYNPDSPLKGTAEIIIGKQRNGPIGSVrltfqgqYSRFDN 455
PRK07004 PRK07004
replicative DNA helicase; Provisional
 6-424 1.04e-67

replicative DNA helicase; Provisional


Pssm-ID: 235907 [Multi-domain]  Cd Length: 460  Bit Score: 223.25  E-value: 1.04e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236   6 EASVIGGLLiggLTPTASDVLAT-LEPEAFSIPLYRKAFEVIRKQARNRNLIDGLMV---------AEECGD-EYATAVm 74
Cdd:PRK07004   22 EQSVLGGLL---LDNAAWDRIADfLSQSDFYRYDHRIIFEHIGRLIAATRPADVITVyealttsgkAEEVGGlAYLNAL- 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236  75 mtARSCPSAANLKGYAGMVADSYQRRQVLQLLDEmrepISNGTLDASGRA----MDDLVKRLSAIRK--PRDEVKPVRLG 148
Cdd:PRK07004   98 --AQNTPSAANIRRYAEIVRDRAVLRRLVSVADE----ISADAFNPQGKEvrqlLDEAESKVFSIAEegARGTQGFLEIG 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 149 EIINDYTDTLDRRLRNGEESDT--LKTGIEELDAITGGMNAEDLVIIAARPGMGKTELALKIAEGVAsrvipgsgVRRG- 225
Cdd:PRK07004  172 PLLTQVVERIDTLYHTANPSDVtgTPTGFVDLDRMTSGMHGGELIIVAGRPSMGKTAFSMNIGEYVA--------VEYGl 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 226 -VLIFSMEMSAIQVVERGIAGAGMMSVSVLRNpSRMDDEGWARVASGMKLLADLDVWVVDASRLSVEEIRSISERHKQEH 304
Cdd:PRK07004  244 pVAVFSMEMPGTQLAMRMLGSVGRLDQHRMRT-GRLTDEDWPKLTHAVQKMSEAQLFIDETGGLNPMELRSRARRLARQC 322

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 305 PNLSLIMADYLGLIEKPKAERNDLA-IAHISGSLKAMAKDLKTPVISLSQLSRDVEKRPNKRPTNADLRDSGSIEQDADS 383
Cdd:PRK07004  323 GKLGLIIIDYLQLMSGSSQGENRATeISEISRSLKSLAKELDVPVIALSQLNRGLEQRPNKRPVMSDLRESGAIEQDADV 402

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*...
gi 1038272236 384 IIMLYREAVYDENSSAAPFAEIIVTKNRFGSLGTV-------YQRFCN 424
Cdd:PRK07004  403 ILFIYRDEVYNPDSPDKGTAEIIIGKQRNGPIGPVrltflgqYTKFDN 450
PRK06904 PRK06904
replicative DNA helicase; Validated
 6-427 3.14e-66

replicative DNA helicase; Validated


Pssm-ID: 136106 [Multi-domain]  Cd Length: 472  Bit Score: 219.87  E-value: 3.14e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236   6 EASVIGGLLIGG--LTPTASDVLAtlepEAFSIPLYRKAFEVIRKQARNRNLIDGLM---------VAEECGDEYATAVM 74
Cdd:PRK06904   30 EQAVLGGIMLDNrhWDSVAERVIA----DDFYTFEHRIIFQEMELLFRQNTPIDLLTldqalktkgKSDEVGGFAYLAEL 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236  75 mtARSCPSAANLKGYAGMVadsyQRRQVLQLLDEMREPISNGTLDASGRAMDDLV------------KRLSAIRKPRDev 142
Cdd:PRK06904  106 --SNNTPSAANILAYADIV----REKAILRELISVGNNIAKNAYSPKGQDIKDILdeaerdvfsiaeKRTTANEGPQN-- 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 143 kpvrlgeIINDYTDTLDR-----RLRNGEESDTLKTGIEELDAITGGMNAEDLVIIAARPGMGKTELALKIAEGVASrvi 217
Cdd:PRK06904  178 -------VINLLENTIDKienlaATPTNNGVTGVTTGFTDLDKKTAGLQPSDLIIVAARPSMGKTTFAMNLCENAAM--- 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 218 pgsGVRRGVLIFSMEMSAIQVVERGIAGAGMMSVSVLRNPSRMDDEGWARVASGMKLLADL-DVWVVDASRLSVEEIRSI 296
Cdd:PRK06904  248 ---ASEKPVLVFSLEMPAEQIMMRMLASLSRVDQTKIRTGQNLDQQDWAKISSTVGMFKQKpNLYIDDSSGLTPTELRSR 324

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 297 SERHKQEHPNLSLIMADYLGLIEKPKAERN-DLAIAHISGSLKAMAKDLKTPVISLSQLSRDVEKRPNKRPTNADLRDSG 375
Cdd:PRK06904  325 ARRVYRENGGLSLIMVDYLQLMRAPGFEDNrTLEIAEISRSLKALAKELKVPVVALSQLNRTLENRGDKRPVNSDLRESG 404

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1038272236 376 SIEQDADSIIMLYREAVYDENSSAAP-FAEIIVTKNRFGSLGTVYQRFcNGHF 427
Cdd:PRK06904  405 SIEQDADLIMFIYRDEVYNETTEDNKgVAEIIIGKQRNGPIGRVRLAF-QGQY 456
PRK07773 PRK07773
replicative DNA helicase; Validated
 3-387 9.08e-64

replicative DNA helicase; Validated


Pssm-ID: 236093 [Multi-domain]  Cd Length: 886  Bit Score: 221.16  E-value: 9.08e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236   3 QDIEA--SVIGGLLiggLTPTA-SDVLATLEPEAFSIPLYRKAFEVI-RKQARNRNlIDGLMVAEEC----------GDE 68
Cdd:PRK07773   26 QDLAAeqSVLGGML---LSKEAiARVLERLRPGAFYRPAHQNIYDAIlDLYGRGEP-ADLVTVAAELdrrgllerigGAP 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236  69 YATAVMMTArscPSAANLKGYAGMVADSYQRRQvlqLLDEMREPISNGTldASGRAMDDLVKRLSA------IRKPRDEV 142
Cdd:PRK07773  102 YLHTLISTV---PTAANADYYARIVAEKALLRR---LIEAGTRIVQYGY--AEGADVAEVVDRAQAeiydvtDRRLSEDF 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 143 KPvrLGEIINDYTDTLDRRLRNGEESDTLKTGIEELDAITGGMNAEDLVIIAARPGMGKTELALKIAEGVASRVipgsgv 222
Cdd:PRK07773  174 VA--LEDLLQPTFDEIDAIASSGGLARGVPTGFTELDAMTNGLHPGQLIIVAARPSMGKTTFGLDFARNCAIRH------ 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 223 RRGVLIFSMEMSAIQVVERGIAGAGMMSVSVLRNpSRMDDEGWARVASGMKLLADLDVWVVDASRLSVEEIRSISERHKQ 302
Cdd:PRK07773  246 RLAVAIFSLEMSKEQLVMRLLSAEAKIKLSDMRS-GRMSDDDWTRLARAMGEISEAPIFIDDTPNLTVMEIRAKARRLRQ 324

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 303 EHPnLSLIMADYLGLIEKPKA-ERNDLAIAHISGSLKAMAKDLKTPVISLSQLSRDVEKRPNKRPTNADLRDSGSIEqdA 381
Cdd:PRK07773  325 EAN-LGLIVVDYLQLMTSGKKyENRQQEVSEISRHLKLLAKELEVPVVALSQLSRGVEQRTDKRPMLSDLRESGCLT--G 401


                  ....*.
gi 1038272236 382 DSIIML 387
Cdd:PRK07773  402 DTLILR 407
PRK09165 PRK09165
replicative DNA helicase; Provisional
 29-424 1.19e-60

replicative DNA helicase; Provisional


Pssm-ID: 181676 [Multi-domain]  Cd Length: 497  Bit Score: 205.50  E-value: 1.19e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236  29 LEPEAFSIPLYRKAFEVIRKQARN---------RNLIDGLMVAEECGDEYATAVMMTArsCPSAANLKGYAGMVADSYQR 99
Cdd:PRK09165   49 LKPEHFFEPLHQRIYEAIAKIIRKgklatpvtlKTFLENDEALGELGGVQYLAKLATE--AVTIINARDYGRIIYDLALR 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 100 RQVLQLLDEMREPISNGTLDASGRA-MDDLVKRLSAI-RKPRDEVKPVRLGEIINDYTDTLDRRLRNGEESDTLKTGIEE 177
Cdd:PRK09165  127 RELINIGEDVVNNAYDAPVDVAPQEqIEDAEQKLYELaETGRYEGGFQSFGTAITEAVDMANAAFKRDGHLSGISTGLRD 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 178 LDAITGGMNAEDLVIIAARPGMGKTELALKIAEGVASRVIPGS-----------GVrrgVLIFSMEMSAIQVVERGIAGA 246
Cdd:PRK09165  207 LDSKLGGLHPSDLIILAGRPSMGKTALATNIAFNAAKAYRREAqpdgskkavngGV---VGFFSLEMSAEQLATRILSEQ 283

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 247 GMMSVSVLRNpSRMDDEGWARVASGMKLLADLDVWVVDASRLSVEEIRSISERHKQEHpNLSLIMADYLGLIEKPKAERN 326
Cdd:PRK09165  284 SEISSSKIRR-GKISEEDFEKLVDASQELQKLPLYIDDTPALSISQLRARARRLKRQH-GLDLLVVDYLQLIRGSSKRSS 361

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 327 D---LAIAHISGSLKAMAKDLKTPVISLSQLSRDVEKRPNKRPTNADLRDSGSIEQDADSIIMLYREAVYDENSSAAP-- 401
Cdd:PRK09165  362 DnrvQEISEITQGLKALAKELNIPVIALSQLSRQVEQRDDKRPQLSDLRESGSIEQDADVVMFVYREEYYLKRKEPREgt 441

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*
gi 1038272236 402 ---------------FAEIIVTKNRFGSLGTV-------YQRFCN 424
Cdd:PRK09165  442 pkheewqekmekvhnKAEVIIAKQRHGPTGTVklafeseFTRFGD 486
PRK06749 PRK06749
replicative DNA helicase; Provisional
 1-428 3.38e-59

replicative DNA helicase; Provisional


Pssm-ID: 168658 [Multi-domain]  Cd Length: 428  Bit Score: 200.18  E-value: 3.38e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236   1 MRQDIEA--SVIGGLLIGGltptasDVL--ATLEPEAFSIPLYRKAFEVIRKQARNRNLIDGLMVAEEC---------GD 67
Cdd:PRK06749    2 SIQNVEAekTVLGSLLLDG------ELIkeCRLTEQYFSMPVHKSIFQLMRKMEDEGQPIDLVTFTSRVdpnflkgigGM 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236  68 EYATAVMmtaRSCPSAANLKGYAGMVADSYQRRQVLQLLDEMREPISNgtlDASGRAMDDLVKRLSAIRKpRDEVKPVRL 147
Cdd:PRK06749   76 EYFIGLM---DGVPTTSNFSYYEGLVRGAWKMYQAGVLGHKMGERLIA---EKSEKIIGETITALCELEE-KDCVCEFDL 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 148 GEIINDYTDTLDRrlrNGEESDTLKTGIEELDAITGGMNAEDLVIIAARPGMGKTELALKIAEGVASrvipgSGVRRGvl 227
Cdd:PRK06749  149 KDALVDLYEELHQ---DAKEITGIETGYTSLNKMTCGLQEGDFVVLGARPSMGKTAFALNVGLHAAK-----SGAAVG-- 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 228 IFSMEMSAIQVVERGIAGAGMMSVSVLRNPS-RMDDEGWARVASGMKLLADLDVWVVDASRLSVEEIRSISERHKQEHPN 306
Cdd:PRK06749  219 LFSLEMSSKQLLKRMASCVGEVSGGRLKNPKhRFAMEDWEKVSKAFAEIGELPLEIYDNAGVTVQDIWMQTRKLKRKHGD 298

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 307 LS-LIMADYLGLIE-KPKAERNDLA-IAHISGSLKAMAKDLKTPVISLSQLSRDVEKRPNKRPTNADLRDSGSIEQDADS 383
Cdd:PRK06749  299 KKiLIIVDYLQLITgDPKHKGNRFQeISEISRKLKLLARELNVCVVALSQLSRSVESRQDKRPLLSDLRETGQIEQDADV 378

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*..
gi 1038272236 384 IIMLYREAVYDENSSAAPFAEIIVTKNRFGSLGTVYQRFCN--GHFV 428
Cdd:PRK06749  379 IMLMYREDYYDKETMQKEMTEIHVAKHRNGPVGSFKLRFLKefGRFV 425
PRK05636 PRK05636
replicative DNA helicase; Provisional
 1-424 1.41e-56

replicative DNA helicase; Provisional


Pssm-ID: 180177 [Multi-domain]  Cd Length: 505  Bit Score: 195.06  E-value: 1.41e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236   1 MRQDIEAS--VIGGLLiggLTPTA-SDVLATLEPEAFSIPLYRKAFEVIRKQARNRNLIDGLMVAEEC----------GD 67
Cdd:PRK05636   70 PPYDNEAEqgVLGAML---LSPDTvIDIVEVLTPEDFYRPAHQLIFQAIIDLFSDNKEIDPVIVAGRLdrtndlervgGA 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236  68 EYATAVMmtaRSCPSAANLKGYAGMVADSYQRRQVLQLLDEMREPISNGTLDASGRAMDDLVKR-LSAIRKPRDEVKPVR 146
Cdd:PRK05636  147 PYLHTLI---QSVPTAANARYYAEIVSEKAVLRRLVDAGTRVVQLGYEGDEGAEIDSVIDRAQQeVFAVSQKNQSEDYAV 223

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 147 LGEIINDYTDTLDRRLRNGEESDTLKTGIEELDAITGGMNAEDLVIIAARPGMGKTELALKIAEGVASRVIPGSgvrrgv 226
Cdd:PRK05636  224 LADILDPTMDELEMLSSQGGIATGIPTGFKDLDDLTNGLRGGQMIIVAARPGVGKSTLALDFMRSASIKHNKAS------ 297

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 227 LIFSMEMSAIQVVERGIAGAGMMSVSVLRNpSRMDDEGWARVASGMKLLADLDVWVVDASRLSVEEIRSISERHKQEHpN 306
Cdd:PRK05636  298 VIFSLEMSKSEIVMRLLSAEAEVRLSDMRG-GKMDEDAWEKLVQRLGKIAQAPIFIDDSANLTMMEIRSKARRLKQKH-D 375

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 307 LSLIMADYLGLIEKPK-AERNDLAIAHISGSLKAMAKDLKTPVISLSQLSRDVEKRPNKRPTNADLRDSGSIEQDADSII 385
Cdd:PRK05636  376 LKLIVVDYLQLMSSGKrVESRQQEVSEFSRQLKLLAKELDVPLIAISQLNRGPESRTDKRPQLADLRESGSLEQDADMVM 455

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*.
gi 1038272236 386 MLYREAVYDENSSAAPFAEIIVTKNRFGSLGTV-------YQRFCN 424
Cdd:PRK05636  456 LLYRPDSQDKDDERAGEADIILAKHRGGPIDTVqvahqlhYSRFVD 501
PRK05595 PRK05595
replicative DNA helicase; Provisional
 1-418 5.90e-56

replicative DNA helicase; Provisional


Pssm-ID: 235525 [Multi-domain]  Cd Length: 444  Bit Score: 191.97  E-value: 5.90e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236   1 MRQDIEA--SVIGGLLIGglTPTASDVLATLEPEAFSIPLYRKAFEVIRKQARNRNLIDGLMVAEEC----------GDE 68
Cdd:PRK05595    8 LPQSIEAeqSVLGAMIID--KTSIAEAAEVLKSEDFYRDSHKVIFSAIIELYQKDIAVDMLTLTENLkstdkleaagGVT 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236  69 YATAVmmtARSCPSAANLKGYAGMVADSYQRRQVLQLLDEMREPISNGTLDASGrAMDDLVKRLS--AIRKPRDEVKPvr 146
Cdd:PRK05595   86 YITEL---SNSIVSTANIQSYIKIVKDKSTLRRLIKSSTEIIENSYNNQDDVEK-VIDSAEKKIFdiSEKRTTSDFEP-- 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 147 LGEIINDYTDTLDRRLRNGEESDTLKTGIEELDAITGGMNAEDLVIIAARPGMGKTELALKIAEGVASRVipgsgvRRGV 226
Cdd:PRK05595  160 LSNVLERGFEQIENLFNNKGETTGVASGFRELDAKTSGFQKGDMILIAARPSMGKTTFALNIAEYAALRE------GKSV 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 227 LIFSMEMSAIQVVERGIAGAGMMSVSVLRNPSrMDDEGWARVASGMKLLADLDVWVVDASRLSVEEIRSISERHKQEHpN 306
Cdd:PRK05595  234 AIFSLEMSKEQLAYKLLCSEANVDMLRLRTGN-LEDKDWENIARASGPLAAAKIFIDDTAGVSVMEMRSKCRRLKIEH-G 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 307 LSLIMADYLGLIEKPK-AERNDLAIAHISGSLKAMAKDLKTPVISLSQLSRDVEKRPNKRPTNADLRDSGSIEQDADSII 385
Cdd:PRK05595  312 IDMILIDYLQLMSGGKgSESRQQEVSEISRSIKALAKEMECPVIALSQLSRAPEQRADHRPMLSDLRESGSIEQDADVVM 391

                         410       420       430
                  ....*....|....*....|....*....|...
gi 1038272236 386 MLYREAVYDENSSAAPFAEIIVTKNRFGSLGTV 418
Cdd:PRK05595  392 FLYRDEYYNKETEDKNVAECIIAKQRNGPTGTV 424
PRK06321 PRK06321
replicative DNA helicase; Provisional
 167-418 6.92e-47

replicative DNA helicase; Provisional


Pssm-ID: 180528 [Multi-domain]  Cd Length: 472  Bit Score: 168.48  E-value: 6.92e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 167 ESDTLKTGIE----ELDAITGGMNAEDLVIIAARPGMGKTELALKIAEGVA-SRVIPgsgvrrgVLIFSMEMSAIQVVER 241
Cdd:PRK06321  201 DSSPMISGIPthfiDLDKMINGFSPSNLMILAARPAMGKTALALNIAENFCfQNRLP-------VGIFSLEMTVDQLIHR 273

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 242 GIAGAGMMSVSVLRNPSrMDDEGWARVASGMKLLADLDVWVVDASRLSVEEIRSISERHKQEHpNLSLIMADYLGLIEKP 321
Cdd:PRK06321  274 IICSRSEVESKKISVGD-LSGRDFQRIVSVVNEMQEHTLLIDDQPGLKITDLRARARRMKESY-DIQFLIIDYLQLLSGS 351

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 322 KAERN----DLAIAHISGSLKAMAKDLKTPVISLSQLSRDVEKRPNKRPTNADLRDSGSIEQDADSIIMLYREAVYDENS 397
Cdd:PRK06321  352 GNLRNsesrQTEISEISRMLKNLARELNIPILCLSQLSRKVEDRANHRPMMSDLRESGSIEQDSDLVMFLLRREYYDPND 431

                         250       260
                  ....*....|....*....|.
gi 1038272236 398 SAApFAEIIVTKNRFGSLGTV 418
Cdd:PRK06321  432 KPG-TAELIVAKNRHGSIGSV 451
DnaB pfam00772
DnaB-like helicase N terminal domain; The hexameric helicase DnaB unwinds the DNA duplex at ...
 3-95 2.82e-14

DnaB-like helicase N terminal domain; The hexameric helicase DnaB unwinds the DNA duplex at the Escherichia coli chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a change in the quaternary structure of the protein involving dimerization of the N-terminal domain has been observed and may occur during the enzymatic cycle. This N-terminal domain is required both for interaction with other proteins in the primosome and for DnaB helicase activity.


Pssm-ID: 395624 [Multi-domain]  Cd Length: 103  Bit Score: 68.42  E-value: 2.82e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236   3 QDIEASVIGGLLIGglTPTASDVLATLEPEAFSIPLYRKAFEVIRKQARNRNLIDGLMVAEEC----------GDEYATA 72
Cdd:pfam00772   6 IEAEQAVLGALLLD--PEAIDEVADILKPEDFYDPAHRLIFEAILDLYDKGEPIDPVTVAEELekkgkledvgGIAYLAE 83

                          90       100
                  ....*....|....*....|...
gi 1038272236  73 VmmtARSCPSAANLKGYAGMVAD 95
Cdd:pfam00772  84 L---AANVPSAANIEYYARIVKE 103
PRK07773 PRK07773
replicative DNA helicase; Validated
 376-428 1.74e-07

replicative DNA helicase; Validated


Pssm-ID: 236093 [Multi-domain]  Cd Length: 886  Bit Score: 53.60  E-value: 1.74e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1038272236 376 SIEQDADSIIMLYREAVYDENSSAAPFAEIIVTKNRFGSLGTVYQRFcNGHFV 428
Cdd:PRK07773  827 SIEQDADVVILLYRPDYYDRDDPRGGEAEFIVAKHRNGPTGTVTLAF-QLHLS 878
RAD55 COG0467
RecA-superfamily ATPase, KaiC/GvpD/RAD55 family [Signal transduction mechanisms];
171-241 9.72e-07

RecA-superfamily ATPase, KaiC/GvpD/RAD55 family [Signal transduction mechanisms];


Pssm-ID: 440235 [Multi-domain]  Cd Length: 221  Bit Score: 49.53  E-value: 9.72e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1038272236 171 LKTGIEELDA-ITGGMNAEDLVIIAARPGMGKTELALKIAEgvasrvipgSGVRRG--VLIFSMEMSAIQVVER 241
Cdd:COG0467     2 VPTGIPGLDElLGGGLPRGSSTLLSGPPGTGKTTLALQFLA---------EGLRRGekGLYVSFEESPEQLLRR 66
RecA-like_Gp4D_helicase cd19483
RecA-like domain of Escherichia coli bacteriophage T7 Gp4D helicase; This family includes the ...
 191-418 3.13e-06

RecA-like domain of Escherichia coli bacteriophage T7 Gp4D helicase; This family includes the RecA-like domain of the Gp4D fragment of the Gene4 helicase-primase (Gp4) from bacteriophage T7. Gp4D (residues 241-566) is the minimal fragment of the Gp4 that forms hexameric rings, it contains the helicase domain and the linker connecting the helicase and primase domains. Helicases are ring-shaped oligomeric enzymes that unwind DNA at the replication fork; they couple NTP hydrolysis to the unwinding of nucleic acid duplexes into their component strands. This family belongs to the RecA-like NTPase superfamily which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410891 [Multi-domain]  Cd Length: 231  Bit Score: 48.34  E-value: 3.13e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 191 VIIAARPGMGKTELALKIAEGVasrvIPGSGVRrgVLIFSMEMSAIQVVeRGIAG--AGMMSVSVLRNPSRMDDEGWARV 268
Cdd:cd19483     1 VTIGAGSGIGKSTIVRELAYHL----ITEHGEK--VGIISLEESVEETA-KGLAGkhLGKPEPLELPRDDITEEEEDDAF 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 269 AsgmKLLADLDVWVVDA-SRLSVEEIRS-ISERHKQEH------PNLSLIMADYlgliekPKAERNDlAIAHISGSLKAM 340
Cdd:cd19483    74 D---NELGSGRFFLYDHfGSLDWDNLKEkIRYMVKVLGckvivlDHLTILVSGL------DSSDERK-ELDEIMTELAAL 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 341 AKDLKTPVISLSQLSRDVEKRP---NKRPTNADLRDSGSIEQDADSIIMLYREAvYDENSSAAPFAEIIVTKNR-FGSLG 416
Cdd:cd19483   144 VKELGVTIILVSHLRRPGGGKGheeGGEVSESDLRGSSAIAQLSDYVIGLERNK-QADDPVERNTTRVRVLKNRfTGETG 222


                  ..
gi 1038272236 417 TV 418
Cdd:cd19483   223 IA 224
RepA COG3598
RecA-family ATPase [Replication, recombination and repair];
190-390 1.22e-04

RecA-family ATPase [Replication, recombination and repair];


Pssm-ID: 442817 [Multi-domain]  Cd Length: 313  Bit Score: 43.74  E-value: 1.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 190 LVIIAARPGMGKTELALKIAEGVAS-RVIPGSGVRRG-VLIFSMEMSAIQVVERgiagagMMSVSVLRNPSRMDDEGWAR 267
Cdd:COG3598    15 VTLLAGPPGTGKSFLALQLAAAVAAgGPWLGRRVPPGkVLYLAAEDDRGELRRR------LKALGADLGLPFADLDGRLR 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 268 VASGMKLLADLDVWvvdasrlsveeiRSISERHKQEHPNLSLI--MADYLGliekpKAERNDLAIAHISGSLKAMAKDLK 345
Cdd:COG3598    89 LLSLAGDLDDTDDL------------EALERAIEEEGPDLVVIdpLARVFG-----GDENDAEEMRAFLNPLDRLAERTG 151

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1038272236 346 TPVISLSQLSrdveKRPNKRPTNADLRDSGSIEQDADSIIMLYRE 390
Cdd:COG3598   152 AAVLLVHHTG----KGGAGKDSGDRARGSSALRGAARSVLVLSRE 192
PRK05973 PRK05973
replicative DNA helicase; Provisional
 189-372 2.36e-04

replicative DNA helicase; Provisional


Pssm-ID: 168322 [Multi-domain]  Cd Length: 237  Bit Score: 42.71  E-value: 2.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 189 DLVIIAARPGMGKTELALKIAEgVASRvipgSGvRRGVLiFSMEMSAIQVVERgiagagmmsvsvLRnpsrmddegwaRV 268
Cdd:PRK05973   65 DLVLLGARPGHGKTLLGLELAV-EAMK----SG-RTGVF-FTLEYTEQDVRDR------------LR-----------AL 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 269 ASGMKLLADLdvWVVDASrlsveeiRSISERHKQEH----PNLSLIMADYLGLIEKpKAERNDLAIAhiSGSLKAMAKDL 344
Cdd:PRK05973  115 GADRAQFADL--FEFDTS-------DAICADYIIARlasaPRGTLVVIDYLQLLDQ-RREKPDLSVQ--VRALKSFARER 182

                         170       180
                  ....*....|....*....|....*...
gi 1038272236 345 KTPVISLSQLSRDVEKRPNKRPTNADLR 372
Cdd:PRK05973  183 GLIIVFISQIDRSFDPSAKPLPDIRDVR 210
RadA_SMS_N cd01121
bacterial RadA DNA repair protein; Sms or bacterial RadA is a DNA repair protein that plays a ...
 165-241 1.38e-03

bacterial RadA DNA repair protein; Sms or bacterial RadA is a DNA repair protein that plays a role in recombination and recombinational repair of DNA damaged by UV radiation, X-rays, and chemical agent and is responsible for the stabilization or processing of branched DNA molecules.


Pssm-ID: 410866 [Multi-domain]  Cd Length: 268  Bit Score: 40.21  E-value: 1.38e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1038272236 165 GEESDTLKTGIEELDAITGG--MNAEdLVIIAARPGMGKTELALKIAEGVASRVIPgsgvrrgVLIFSMEMSAIQVVER 241
Cdd:cd01121    58 AEEEERISTGIGELDRVLGGglVPGS-VVLIGGDPGIGKSTLLLQVAARLAQRGGK-------VLYVSGEESLSQIKLR 128
KaiC-like_N cd19488
N-terminal domain of KaiC family protein; uncharacterized subfamily; KaiC is a circadian clock ...
 171-213 2.38e-03

N-terminal domain of KaiC family protein; uncharacterized subfamily; KaiC is a circadian clock protein, most studied in cyanobacteria. KaiC, an autokinase, autophosphatase, and ATPase, is part of the core oscillator, composed of three proteins: KaiA, KaiB, and KaiC. The circadian oscillation is regulated via KaiC phosphorylation.


Pssm-ID: 410896 [Multi-domain]  Cd Length: 225  Bit Score: 39.25  E-value: 2.38e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1038272236 171 LKTGIEELDAI-TGGMNAEDLVIIAARPGMGKTELALK-IAEGVA 213
Cdd:cd19488     1 ISTGIPGLDDIlRGGLPPRRLYLVEGAPGTGKTTLALQfLLEGAA 45
KaiC-like cd01124
Circadian Clock Protein KaiC; KaiC is a circadian clock protein, most studied in cyanobacteria. ...
 171-414 8.14e-03

Circadian Clock Protein KaiC; KaiC is a circadian clock protein, most studied in cyanobacteria. KaiC, an autokinase, autophosphatase, and ATPase, is part of the core oscillator, composed of three proteins: KaiA, KaiB, and KaiC. The circadian oscillation is regulated via KaiC phosphorylation.


Pssm-ID: 410869 [Multi-domain]  Cd Length: 222  Bit Score: 37.63  E-value: 8.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 171 LKTGIEELDAITGGMNAED-LVIIAARPGMGKTELALKIAEGVASRVIPGsgvrrgvLIFSMEMSAIQVVERGiAGAGMm 249
Cdd:cd01124     1 VKTGIPGLDELLGGGIPKGsVTLLTGGPGTGKTLFGLQFLYAGAKNGEPG-------LFFTFEESPERLLRNA-KSFGW- 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 250 svsvlrNPSRMDDEGwarvasgmkLLADLDVWVVDASRLSVEEIRSISERHKQEHpNLSLIMADYLGLIEKPKAERNdLA 329
Cdd:cd01124    72 ------DFDEMEDEG---------KLIIVDAPPTEAGRFSLDELLSRILSIIKSF-KAKRVVIDSLSGLRRAKEDQM-RA 134

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038272236 330 IAHISgSLKAMAKDLKTPVISLSQLSRDvekrpnkrpTNADLRDSGSIEQDADSIIMLYREAVYDENSSAapfaeIIVTK 409
Cdd:cd01124   135 RRIVI-ALLNELRAAGVTTIFTSEMRSF---------LSSESAGGGDVSFIVDGVILLRYVEIEGELRRT-----IRVLK 199


                  ....*
gi 1038272236 410 NRFGS 414
Cdd:cd01124   200 MRGTG 204
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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