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Conserved domains on  [gi|1039748506|ref|XP_017172002|]
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sodium channel protein type 8 subunit alpha isoform X1 [Mus musculus]

Protein Classification

Na_trans_cytopl and Na_trans_assoc domain-containing protein( domain architecture ID 13634396)

protein containing domains Na_trans_cytopl, Na_trans_assoc, Na_channel_gate, and IQ

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Na_trans_assoc pfam06512
Sodium ion transport-associated; Members of this family contain a region found exclusively in ...
999-1200 1.38e-68

Sodium ion transport-associated; Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of pfam00520 and, less often, one copy of pfam00612.


:

Pssm-ID: 461936  Cd Length: 195  Bit Score: 229.53  E-value: 1.38e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748506  999 DGEMNNLQISVIRIKKGVAWAKVKVHAFMQAHFKQREADEVKPLDELYE---KKANCIANHTGVDIHRNGdfqkngngtt 1075
Cdd:pfam06512    1 DGEMNNLQIALARIQRGIRFVKSTLRDFCCRLCKEPQLPKKKPLTELKDarsKLTNQIANHTSLKKAPGG---------- 70
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748506 1076 sgigssveKYIIDEDHMSFINNPNLTVRVPIAVGESDFENLNTEDVSSE-SDPEGSKD----KLDDTSSSEGSTIDIKPE 1150
Cdd:pfam06512   71 --------KYELDEDHMDFITNPNLTVCVPIAEGESDLENEEDDDESSQsSDEEKSKQqeqlEDDDSSSSEGSTVDLQDP 142
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1039748506 1151 VEEVPVEQPEE--YLDPDACFTEGCVQRFKCCQVNIEEGLGKSWWILRKTCF 1200
Cdd:pfam06512  143 EEELEKIPEEAeeLKEPEDCFTEGCVRRFPCCAVDTTKGPWKIWWNLRKTCY 194
Na_trans_cytopl pfam11933
Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain ...
546-710 7.32e-68

Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain towards the start of voltage-dependent sodium ion channel proteins in eukaryotes. It is found closely associated with pfam06512 and pfam00520.


:

Pssm-ID: 463401  Cd Length: 163  Bit Score: 226.15  E-value: 7.32e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748506  546 SLLSIPGSPFLSRHNSKSSIFSFRGpgRFRDPGSENEFADDEHSTVEESEGRRDSLFIPIRARERRssysgYSGYSQCSR 625
Cdd:pfam11933    1 SLLSIPGSPFSPRRSSRGSIFSFRG--RGRDVGSENDFADDENSTFEDSESRRGSLFVPRRHLERR-----SSYQSQASR 73
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748506  626 SSRIFPSLRRSVKRNSTVDCNGVVSLIG----PGSHIGRLLPEVKIDKAAT-DSATTEVEIKKKGPGSLLVSMEQLASYG 700
Cdd:pfam11933   74 SSRSHPGLPQNGKRHSTVDCNGVVSLVGggpePTSPGGQLLPEVILDKPATgDSTTTEEELRKRRLSSYQLSMDYLEEPF 153
                          170
                   ....*....|
gi 1039748506  701 RKDRINSIMS 710
Cdd:pfam11933  154 QRQRAVSAAS 163
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1205-1481 3.84e-64

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 218.29  E-value: 3.84e-64
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748506 1205 HNWFETFIIFMILLSSGALAFEDIYIEQRKTIrTILEYADKVFTYIFILEMLLKWTAYGFVK-FFTNAWCWLDFLIVAVS 1283
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLT-TVLEILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPS 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748506 1284 LVSLIANalGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKYhy 1363
Cdd:pfam00520   80 LISLVLS--SVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL-- 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748506 1364 cfnetseirfeidevnnktdceklmegnNTEIRWKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRkpdeqpdye 1443
Cdd:pfam00520  156 ----------------------------KTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGK--------- 198
                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 1039748506 1444 GNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK 1481
Cdd:pfam00520  199 GEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTER 236
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1530-1784 1.85e-57

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 199.42  E-value: 1.85e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748506 1530 QAFDIVIMMLICLNMVTMMVETDTQSKQ-MENILYWINLVFVIFFTCECVLKMFALR--HYYFTIGWNIFDFVVVILSIV 1606
Cdd:pfam00520    2 RYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGfkKRYFRSPWNILDFVVVLPSLI 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748506 1607 GMFLADIiekyfVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYV-- 1684
Cdd:pfam00520   82 SLVLSSV-----GSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKlk 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748506 1685 KHEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLLPILNRPPdcsldkehpgsgfkgdcgnPSVGIFFFVSYIIISFLI 1764
Cdd:pfam00520  157 TWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG-------------------EFWAYIYFVSFIILGGFL 217
                          250       260
                   ....*....|....*....|
gi 1039748506 1765 VVNMYIAIILENFSVATEES 1784
Cdd:pfam00520  218 LLNLFIAVIIDNFQELTERT 237
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
760-973 2.31e-55

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 193.25  E-value: 2.31e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748506  760 DPFVDLAITICIVLNTLFMAMEHHPMTPQ-FEHVLAVGNLVFTGIFTAEMFLKLIAMDP-YYYFQEGWNIFDGFIVSLSL 837
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748506  838 MELGLADVE---GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYkecvc 914
Cdd:pfam00520   81 ISLVLSSVGslsGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL----- 155
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748506  915 KISQECKLPRWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQAMCLIVFMMVMVIGN 973
Cdd:pfam00520  156 KTWENPDNGRTNFDNFPNAFLWLFQTMTTEgWGDIMYDTIDGKGEFWAYIYFVSFIILGG 215
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
131-421 9.58e-50

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 177.07  E-value: 9.58e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748506  131 HSVFSMIIMCTILTNCVFMTFSNPPE-------WSKNVEYTFTGIYTFESLVKIIARGFCidgFTFLRDPWNWLDFSVIM 203
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQpeeplttVLEILDYVFTGIFTLEMLLKIIAAGFK---KRYFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748506  204 MAYVT----EFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRN 279
Cdd:pfam00520   78 PSLISlvlsSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748506  280 kcvvwpinfnesylengtrgfdweeyinnktnfymvpgmlepllcgnssdagqcpegfqcmkaGRNPNYGYTSFDTFSWA 359
Cdd:pfam00520  158 ---------------------------------------------------------------WENPDNGRTNFDNFPNA 174
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039748506  360 FLALFRLMTQDYWENLYQLTLRAAGKTYM-IFFVLVIFVGSFYLVNLILAVVAMAYEEQNQAT 421
Cdd:pfam00520  175 FLWLFQTMTTEGWGDIMYDTIDGKGEFWAyIYFVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
Na_channel_gate cd13433
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of ...
1473-1525 3.34e-31

Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of the intracellular linker between domains III and IV of the alpha subunits of voltage-gated sodium channels. It is responsible for fast inactivation of the channel and essential for proper physiological function.


:

Pssm-ID: 240441  Cd Length: 54  Bit Score: 116.90  E-value: 3.34e-31
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1039748506 1473 DNFNQQKKKFGG-QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKIQGIVFD 1525
Cdd:cd13433      1 DNFNQLKKKYGGgLDIFLTESQKKYYNAMKKLGSKKPQKPIPRPKNKFQGFIFD 54
IQ smart00015
Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln ...
1902-1923 1.51e-03

Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln residues.


:

Pssm-ID: 197470 [Multi-domain]  Cd Length: 23  Bit Score: 37.69  E-value: 1.51e-03
                            10        20
                    ....*....|....*....|..
gi 1039748506  1902 QEEVSAVVLQRAYRGHLARRGF 1923
Cdd:smart00015    1 RLTRAAIIIQAAWRGYLARKRY 22
 
Name Accession Description Interval E-value
Na_trans_assoc pfam06512
Sodium ion transport-associated; Members of this family contain a region found exclusively in ...
999-1200 1.38e-68

Sodium ion transport-associated; Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of pfam00520 and, less often, one copy of pfam00612.


Pssm-ID: 461936  Cd Length: 195  Bit Score: 229.53  E-value: 1.38e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748506  999 DGEMNNLQISVIRIKKGVAWAKVKVHAFMQAHFKQREADEVKPLDELYE---KKANCIANHTGVDIHRNGdfqkngngtt 1075
Cdd:pfam06512    1 DGEMNNLQIALARIQRGIRFVKSTLRDFCCRLCKEPQLPKKKPLTELKDarsKLTNQIANHTSLKKAPGG---------- 70
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748506 1076 sgigssveKYIIDEDHMSFINNPNLTVRVPIAVGESDFENLNTEDVSSE-SDPEGSKD----KLDDTSSSEGSTIDIKPE 1150
Cdd:pfam06512   71 --------KYELDEDHMDFITNPNLTVCVPIAEGESDLENEEDDDESSQsSDEEKSKQqeqlEDDDSSSSEGSTVDLQDP 142
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1039748506 1151 VEEVPVEQPEE--YLDPDACFTEGCVQRFKCCQVNIEEGLGKSWWILRKTCF 1200
Cdd:pfam06512  143 EEELEKIPEEAeeLKEPEDCFTEGCVRRFPCCAVDTTKGPWKIWWNLRKTCY 194
Na_trans_cytopl pfam11933
Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain ...
546-710 7.32e-68

Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain towards the start of voltage-dependent sodium ion channel proteins in eukaryotes. It is found closely associated with pfam06512 and pfam00520.


Pssm-ID: 463401  Cd Length: 163  Bit Score: 226.15  E-value: 7.32e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748506  546 SLLSIPGSPFLSRHNSKSSIFSFRGpgRFRDPGSENEFADDEHSTVEESEGRRDSLFIPIRARERRssysgYSGYSQCSR 625
Cdd:pfam11933    1 SLLSIPGSPFSPRRSSRGSIFSFRG--RGRDVGSENDFADDENSTFEDSESRRGSLFVPRRHLERR-----SSYQSQASR 73
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748506  626 SSRIFPSLRRSVKRNSTVDCNGVVSLIG----PGSHIGRLLPEVKIDKAAT-DSATTEVEIKKKGPGSLLVSMEQLASYG 700
Cdd:pfam11933   74 SSRSHPGLPQNGKRHSTVDCNGVVSLVGggpePTSPGGQLLPEVILDKPATgDSTTTEEELRKRRLSSYQLSMDYLEEPF 153
                          170
                   ....*....|
gi 1039748506  701 RKDRINSIMS 710
Cdd:pfam11933  154 QRQRAVSAAS 163
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1205-1481 3.84e-64

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 218.29  E-value: 3.84e-64
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748506 1205 HNWFETFIIFMILLSSGALAFEDIYIEQRKTIrTILEYADKVFTYIFILEMLLKWTAYGFVK-FFTNAWCWLDFLIVAVS 1283
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLT-TVLEILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPS 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748506 1284 LVSLIANalGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKYhy 1363
Cdd:pfam00520   80 LISLVLS--SVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL-- 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748506 1364 cfnetseirfeidevnnktdceklmegnNTEIRWKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRkpdeqpdye 1443
Cdd:pfam00520  156 ----------------------------KTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGK--------- 198
                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 1039748506 1444 GNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK 1481
Cdd:pfam00520  199 GEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTER 236
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1530-1784 1.85e-57

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 199.42  E-value: 1.85e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748506 1530 QAFDIVIMMLICLNMVTMMVETDTQSKQ-MENILYWINLVFVIFFTCECVLKMFALR--HYYFTIGWNIFDFVVVILSIV 1606
Cdd:pfam00520    2 RYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGfkKRYFRSPWNILDFVVVLPSLI 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748506 1607 GMFLADIiekyfVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYV-- 1684
Cdd:pfam00520   82 SLVLSSV-----GSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKlk 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748506 1685 KHEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLLPILNRPPdcsldkehpgsgfkgdcgnPSVGIFFFVSYIIISFLI 1764
Cdd:pfam00520  157 TWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG-------------------EFWAYIYFVSFIILGGFL 217
                          250       260
                   ....*....|....*....|
gi 1039748506 1765 VVNMYIAIILENFSVATEES 1784
Cdd:pfam00520  218 LLNLFIAVIIDNFQELTERT 237
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
760-973 2.31e-55

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 193.25  E-value: 2.31e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748506  760 DPFVDLAITICIVLNTLFMAMEHHPMTPQ-FEHVLAVGNLVFTGIFTAEMFLKLIAMDP-YYYFQEGWNIFDGFIVSLSL 837
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748506  838 MELGLADVE---GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYkecvc 914
Cdd:pfam00520   81 ISLVLSSVGslsGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL----- 155
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748506  915 KISQECKLPRWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQAMCLIVFMMVMVIGN 973
Cdd:pfam00520  156 KTWENPDNGRTNFDNFPNAFLWLFQTMTTEgWGDIMYDTIDGKGEFWAYIYFVSFIILGG 215
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
131-421 9.58e-50

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 177.07  E-value: 9.58e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748506  131 HSVFSMIIMCTILTNCVFMTFSNPPE-------WSKNVEYTFTGIYTFESLVKIIARGFCidgFTFLRDPWNWLDFSVIM 203
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQpeeplttVLEILDYVFTGIFTLEMLLKIIAAGFK---KRYFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748506  204 MAYVT----EFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRN 279
Cdd:pfam00520   78 PSLISlvlsSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748506  280 kcvvwpinfnesylengtrgfdweeyinnktnfymvpgmlepllcgnssdagqcpegfqcmkaGRNPNYGYTSFDTFSWA 359
Cdd:pfam00520  158 ---------------------------------------------------------------WENPDNGRTNFDNFPNA 174
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039748506  360 FLALFRLMTQDYWENLYQLTLRAAGKTYM-IFFVLVIFVGSFYLVNLILAVVAMAYEEQNQAT 421
Cdd:pfam00520  175 FLWLFQTMTTEGWGDIMYDTIDGKGEFWAyIYFVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
Na_channel_gate cd13433
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of ...
1473-1525 3.34e-31

Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of the intracellular linker between domains III and IV of the alpha subunits of voltage-gated sodium channels. It is responsible for fast inactivation of the channel and essential for proper physiological function.


Pssm-ID: 240441  Cd Length: 54  Bit Score: 116.90  E-value: 3.34e-31
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1039748506 1473 DNFNQQKKKFGG-QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKIQGIVFD 1525
Cdd:cd13433      1 DNFNQLKKKYGGgLDIFLTESQKKYYNAMKKLGSKKPQKPIPRPKNKFQGFIFD 54
IQ smart00015
Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln ...
1902-1923 1.51e-03

Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln residues.


Pssm-ID: 197470 [Multi-domain]  Cd Length: 23  Bit Score: 37.69  E-value: 1.51e-03
                            10        20
                    ....*....|....*....|..
gi 1039748506  1902 QEEVSAVVLQRAYRGHLARRGF 1923
Cdd:smart00015    1 RLTRAAIIIQAAWRGYLARKRY 22
 
Name Accession Description Interval E-value
Na_trans_assoc pfam06512
Sodium ion transport-associated; Members of this family contain a region found exclusively in ...
999-1200 1.38e-68

Sodium ion transport-associated; Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of pfam00520 and, less often, one copy of pfam00612.


Pssm-ID: 461936  Cd Length: 195  Bit Score: 229.53  E-value: 1.38e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748506  999 DGEMNNLQISVIRIKKGVAWAKVKVHAFMQAHFKQREADEVKPLDELYE---KKANCIANHTGVDIHRNGdfqkngngtt 1075
Cdd:pfam06512    1 DGEMNNLQIALARIQRGIRFVKSTLRDFCCRLCKEPQLPKKKPLTELKDarsKLTNQIANHTSLKKAPGG---------- 70
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748506 1076 sgigssveKYIIDEDHMSFINNPNLTVRVPIAVGESDFENLNTEDVSSE-SDPEGSKD----KLDDTSSSEGSTIDIKPE 1150
Cdd:pfam06512   71 --------KYELDEDHMDFITNPNLTVCVPIAEGESDLENEEDDDESSQsSDEEKSKQqeqlEDDDSSSSEGSTVDLQDP 142
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1039748506 1151 VEEVPVEQPEE--YLDPDACFTEGCVQRFKCCQVNIEEGLGKSWWILRKTCF 1200
Cdd:pfam06512  143 EEELEKIPEEAeeLKEPEDCFTEGCVRRFPCCAVDTTKGPWKIWWNLRKTCY 194
Na_trans_cytopl pfam11933
Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain ...
546-710 7.32e-68

Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain towards the start of voltage-dependent sodium ion channel proteins in eukaryotes. It is found closely associated with pfam06512 and pfam00520.


Pssm-ID: 463401  Cd Length: 163  Bit Score: 226.15  E-value: 7.32e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748506  546 SLLSIPGSPFLSRHNSKSSIFSFRGpgRFRDPGSENEFADDEHSTVEESEGRRDSLFIPIRARERRssysgYSGYSQCSR 625
Cdd:pfam11933    1 SLLSIPGSPFSPRRSSRGSIFSFRG--RGRDVGSENDFADDENSTFEDSESRRGSLFVPRRHLERR-----SSYQSQASR 73
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748506  626 SSRIFPSLRRSVKRNSTVDCNGVVSLIG----PGSHIGRLLPEVKIDKAAT-DSATTEVEIKKKGPGSLLVSMEQLASYG 700
Cdd:pfam11933   74 SSRSHPGLPQNGKRHSTVDCNGVVSLVGggpePTSPGGQLLPEVILDKPATgDSTTTEEELRKRRLSSYQLSMDYLEEPF 153
                          170
                   ....*....|
gi 1039748506  701 RKDRINSIMS 710
Cdd:pfam11933  154 QRQRAVSAAS 163
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1205-1481 3.84e-64

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 218.29  E-value: 3.84e-64
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748506 1205 HNWFETFIIFMILLSSGALAFEDIYIEQRKTIrTILEYADKVFTYIFILEMLLKWTAYGFVK-FFTNAWCWLDFLIVAVS 1283
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLT-TVLEILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPS 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748506 1284 LVSLIANalGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKYhy 1363
Cdd:pfam00520   80 LISLVLS--SVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL-- 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748506 1364 cfnetseirfeidevnnktdceklmegnNTEIRWKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRkpdeqpdye 1443
Cdd:pfam00520  156 ----------------------------KTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGK--------- 198
                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 1039748506 1444 GNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK 1481
Cdd:pfam00520  199 GEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTER 236
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1530-1784 1.85e-57

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 199.42  E-value: 1.85e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748506 1530 QAFDIVIMMLICLNMVTMMVETDTQSKQ-MENILYWINLVFVIFFTCECVLKMFALR--HYYFTIGWNIFDFVVVILSIV 1606
Cdd:pfam00520    2 RYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGfkKRYFRSPWNILDFVVVLPSLI 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748506 1607 GMFLADIiekyfVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYV-- 1684
Cdd:pfam00520   82 SLVLSSV-----GSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKlk 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748506 1685 KHEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLLPILNRPPdcsldkehpgsgfkgdcgnPSVGIFFFVSYIIISFLI 1764
Cdd:pfam00520  157 TWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG-------------------EFWAYIYFVSFIILGGFL 217
                          250       260
                   ....*....|....*....|
gi 1039748506 1765 VVNMYIAIILENFSVATEES 1784
Cdd:pfam00520  218 LLNLFIAVIIDNFQELTERT 237
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
760-973 2.31e-55

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 193.25  E-value: 2.31e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748506  760 DPFVDLAITICIVLNTLFMAMEHHPMTPQ-FEHVLAVGNLVFTGIFTAEMFLKLIAMDP-YYYFQEGWNIFDGFIVSLSL 837
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748506  838 MELGLADVE---GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYkecvc 914
Cdd:pfam00520   81 ISLVLSSVGslsGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL----- 155
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748506  915 KISQECKLPRWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQAMCLIVFMMVMVIGN 973
Cdd:pfam00520  156 KTWENPDNGRTNFDNFPNAFLWLFQTMTTEgWGDIMYDTIDGKGEFWAYIYFVSFIILGG 215
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
131-421 9.58e-50

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 177.07  E-value: 9.58e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748506  131 HSVFSMIIMCTILTNCVFMTFSNPPE-------WSKNVEYTFTGIYTFESLVKIIARGFCidgFTFLRDPWNWLDFSVIM 203
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQpeeplttVLEILDYVFTGIFTLEMLLKIIAAGFK---KRYFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748506  204 MAYVT----EFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRN 279
Cdd:pfam00520   78 PSLISlvlsSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748506  280 kcvvwpinfnesylengtrgfdweeyinnktnfymvpgmlepllcgnssdagqcpegfqcmkaGRNPNYGYTSFDTFSWA 359
Cdd:pfam00520  158 ---------------------------------------------------------------WENPDNGRTNFDNFPNA 174
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039748506  360 FLALFRLMTQDYWENLYQLTLRAAGKTYM-IFFVLVIFVGSFYLVNLILAVVAMAYEEQNQAT 421
Cdd:pfam00520  175 FLWLFQTMTTEGWGDIMYDTIDGKGEFWAyIYFVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
Na_channel_gate cd13433
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of ...
1473-1525 3.34e-31

Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of the intracellular linker between domains III and IV of the alpha subunits of voltage-gated sodium channels. It is responsible for fast inactivation of the channel and essential for proper physiological function.


Pssm-ID: 240441  Cd Length: 54  Bit Score: 116.90  E-value: 3.34e-31
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1039748506 1473 DNFNQQKKKFGG-QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKIQGIVFD 1525
Cdd:cd13433      1 DNFNQLKKKYGGgLDIFLTESQKKYYNAMKKLGSKKPQKPIPRPKNKFQGFIFD 54
PKD_channel pfam08016
Polycystin cation channel; This family contains the cation channel region from group II of ...
1561-1778 7.04e-06

Polycystin cation channel; This family contains the cation channel region from group II of Transient receptor potential (TRP) channels, the TRPP subfamily, including PKD1, PKD2, PKD2L and mucolipin proteins.


Pssm-ID: 462341 [Multi-domain]  Cd Length: 225  Bit Score: 49.20  E-value: 7.04e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748506 1561 ILYWINLVFVIFFTCECVLKMFALRHYYFTIGWNIFDFVVVILSIVGMFLAdiIEKYFVSPTLFRVI-----------RL 1629
Cdd:pfam08016   12 LCEIVFVVFFLYFVVEEILKIRKHRPSYLRSVWNLLDLAIVILSVVLIVLN--IYRDFLADRLIKSVeaspvtfidfdRV 89
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748506 1630 ARIGRILRLIKG----------------AKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAyvKHEAgiddm 1693
Cdd:pfam08016   90 AQLDNLYRIILAflvfltwlklfkvlrfNKTMSLFTKTLSRAWKDLAGFALMFVIFFFAYAQFGYLLFG--TQAP----- 162
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748506 1694 fNFETFGNSMICLFQITTSA-GWDGLllpilnrppdcsldkehpgsgfkgDCGNPSVGIFFFVSYIIISFLIVVNMYIAI 1772
Cdd:pfam08016  163 -NFSNFVKSILTLFRTILGDfGYNEI------------------------FSGNRVLGPLLFLTFVFLVIFILLNLFLAI 217

                   ....*.
gi 1039748506 1773 ILENFS 1778
Cdd:pfam08016  218 INDSYV 223
IQ smart00015
Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln ...
1902-1923 1.51e-03

Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln residues.


Pssm-ID: 197470 [Multi-domain]  Cd Length: 23  Bit Score: 37.69  E-value: 1.51e-03
                            10        20
                    ....*....|....*....|..
gi 1039748506  1902 QEEVSAVVLQRAYRGHLARRGF 1923
Cdd:smart00015    1 RLTRAAIIIQAAWRGYLARKRY 22
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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