NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1039768216|ref|XP_017175803|]
View 

enoyl-CoA hydratase domain-containing protein 2, mitochondrial isoform X1 [Mus musculus]

Protein Classification

Clp protease/crotonase-like domain-containing protein( domain architecture ID 581041)

Clp protease/crotonase-like domain-containing protein similar to Oryza sativa enoyl-CoA delta isomerase which plays a role in fatty acid metabolism, which involves stabilization of an enolate anion intermediate derived from an acyl-CoA substrate

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
crotonase-like super family cl23717
Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse ...
 1-191 4.97e-77

Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.


The actual alignment was detected with superfamily member PLN02600:

Pssm-ID: 474030 [Multi-domain]  Cd Length: 251  Bit Score: 230.85  E-value: 4.97e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216   1 MSDVEVGTFVQRLRGLMSEIAAFPVPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCL 80
Cdd:PLN02600   65 MSPSEVQKFVNSLRSTFSSLEALSIPTIAVVEGAALGGGLELALSCDLRICGEEAVFGLPETGLAIIPGAGGTQRLPRLV 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  81 GVALAKELIFTGRRLNGAQARELGLVNHAVAQNEegnaAYHRALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIE 160
Cdd:PLN02600  145 GRSRAKELIFTGRRIGAREAASMGLVNYCVPAGE----AYEKALELAQEINQKGPLAIKMAKKAINEGSEVDMASGLEIE 220

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1039768216 161 QMCYAQNIPTQDRLEGMAAFREKRAPKFVGK 191
Cdd:PLN02600  221 EECYEQVLKTKDRLEGLAAFAEKRKPVYTGK 251
 
Name Accession Description Interval E-value
PLN02600 PLN02600
enoyl-CoA hydratase
 1-191 4.97e-77

enoyl-CoA hydratase


Pssm-ID: 178210 [Multi-domain]  Cd Length: 251  Bit Score: 230.85  E-value: 4.97e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216   1 MSDVEVGTFVQRLRGLMSEIAAFPVPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCL 80
Cdd:PLN02600   65 MSPSEVQKFVNSLRSTFSSLEALSIPTIAVVEGAALGGGLELALSCDLRICGEEAVFGLPETGLAIIPGAGGTQRLPRLV 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  81 GVALAKELIFTGRRLNGAQARELGLVNHAVAQNEegnaAYHRALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIE 160
Cdd:PLN02600  145 GRSRAKELIFTGRRIGAREAASMGLVNYCVPAGE----AYEKALELAQEINQKGPLAIKMAKKAINEGSEVDMASGLEIE 220

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1039768216 161 QMCYAQNIPTQDRLEGMAAFREKRAPKFVGK 191
Cdd:PLN02600  221 EECYEQVLKTKDRLEGLAAFAEKRKPVYTGK 251
CaiD COG1024
Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase ...
 5-185 3.57e-59

Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase/carnithine racemase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440647 [Multi-domain]  Cd Length: 249  Bit Score: 185.37  E-value: 3.57e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216   5 EVGTFVQRLRGLMSEIAAFPVPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVAL 84
Cdd:COG1024    73 EARAFARGLQRLFRALRRLPKPVIAAVNGAALGGGLELALACDLRIAAEDARFGLPEVRLGLIPGGGGTQRLPRLVGLAR 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  85 AKELIFTGRRLNGAQARELGLVNHAVAQNEegnaAYHRALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEQMCY 164
Cdd:COG1024   153 AKELLLTGRRIDAEEALELGLVNRVVPDDE----LLAAALALAARLAAGPPLALAATKRALNAALEAPLDEALELEAEAF 228

                         170       180
                  ....*....|....*....|.
gi 1039768216 165 AQNIPTQDRLEGMAAFREKRA 185
Cdd:COG1024   229 AELFASEDAREGIAAFLEKRK 249
crotonase-like cd06558
Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse ...
 2-130 1.77e-41

Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.


Pssm-ID: 119339 [Multi-domain]  Cd Length: 195  Bit Score: 138.46  E-value: 1.77e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216   2 SDVEVGTFVQRLRGLMSEIAAFPVPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLG 81
Cdd:cd06558    71 AGEEARAFIRELQELLRALLRLPKPVIAAVNGAALGGGLELALACDIRIAAEDAKFGLPEVKLGLVPGGGGTQRLPRLVG 150

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1039768216  82 VALAKELIFTGRRLNGAQARELGLVNHAVAQNEegnaAYHRALALAQEI 130
Cdd:cd06558   151 PARARELLLTGRRISAEEALELGLVDEVVPDEE----LLAAALELARRL 195
ECH_1 pfam00378
Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: ...
 16-191 4.79e-40

Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: enoyl-CoA hydratase, napthoate synthase, carnitate racemase, 3-hydroxybutyryl-CoA dehydratase and dodecanoyl-CoA delta-isomerase.


Pssm-ID: 395302 [Multi-domain]  Cd Length: 251  Bit Score: 136.34  E-value: 4.79e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  16 LMSEIAAFPVPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRL 95
Cdd:pfam00378  80 LWTLLYTCPKPVIAAVNGYAIGGGCELALACDIIIAADNASFGLNETKLGIIPGAGGTDRLPRIIGHSKAMEMLLLGRRI 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  96 NGAQARELGLVNHAVAQNEegnaAYHRALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEQMCYAQNIPTQDRLE 175
Cdd:pfam00378 160 SAQEALKWGLVDKVVPEDQ----LLDEARELAEKLAEKSPAALAQLKKALNAKLEDALPTQLEAEARLFYSTFSKDDIIE 235

                         170
                  ....*....|....*.
gi 1039768216 176 GMAAFREKRAPKFVGK 191
Cdd:pfam00378 236 GLQAFLEKRKPPWEDQ 251
fa_ox_alpha_mit TIGR02441
fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of ...
 5-147 1.71e-22

fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of mitochondrial multifunctional fatty acid degradation enzyme complex. Subunit activities include: enoyl-CoA hydratase (EC 4.2.1.17) _ 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35). Some characterization in human (SP:P40939), pig (SP:Q29554), and rat (SP:Q64428). The beta subunit has activity: acetyl-CoA C-acyltransferase (EC 2.3.1.16).


Pssm-ID: 131494 [Multi-domain]  Cd Length: 737  Bit Score: 94.13  E-value: 1.71e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216   5 EVGTFVQRLRGLMSEIAAFPVPTIAAMDGFALGGGLELALACDLRIAA--SSAVMGLIETTRGLLPGAGGTQRLPRCLGV 82
Cdd:TIGR02441  89 EVTQLSQEGQEMFERIEKSQKPIVAAISGSCLGGGLELALACHYRIATkdRKTLLGLPEVMLGLLPGAGGTQRLPKLTGV 168

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039768216  83 ALAKELIFTGRRLNGAQARELGLVNHAVAQNEEG-NAAYHRALALAQEILPQAPIAVRLGKVAIDR 147
Cdd:TIGR02441 169 PAALDMMLTGKKIRADRAKKMGIVDQLVDPLGPGlKPAEENTIEYLEEVAVKFAQGLANGKLSINR 234
 
Name Accession Description Interval E-value
PLN02600 PLN02600
enoyl-CoA hydratase
 1-191 4.97e-77

enoyl-CoA hydratase


Pssm-ID: 178210 [Multi-domain]  Cd Length: 251  Bit Score: 230.85  E-value: 4.97e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216   1 MSDVEVGTFVQRLRGLMSEIAAFPVPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCL 80
Cdd:PLN02600   65 MSPSEVQKFVNSLRSTFSSLEALSIPTIAVVEGAALGGGLELALSCDLRICGEEAVFGLPETGLAIIPGAGGTQRLPRLV 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  81 GVALAKELIFTGRRLNGAQARELGLVNHAVAQNEegnaAYHRALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIE 160
Cdd:PLN02600  145 GRSRAKELIFTGRRIGAREAASMGLVNYCVPAGE----AYEKALELAQEINQKGPLAIKMAKKAINEGSEVDMASGLEIE 220

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1039768216 161 QMCYAQNIPTQDRLEGMAAFREKRAPKFVGK 191
Cdd:PLN02600  221 EECYEQVLKTKDRLEGLAAFAEKRKPVYTGK 251
PRK07657 PRK07657
enoyl-CoA hydratase; Provisional
 1-191 3.34e-75

enoyl-CoA hydratase; Provisional


Pssm-ID: 181069 [Multi-domain]  Cd Length: 260  Bit Score: 226.54  E-value: 3.34e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216   1 MSDVEVGTFVQRLRGLMSEIAAFPVPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCL 80
Cdd:PRK07657   74 MNEEQVRHAVSLIRTTMEMVEQLPQPVIAAINGIALGGGLELALACDFRIAAESASLGLTETTLAIIPGAGGTQRLPRLI 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  81 GVALAKELIFTGRRLNGAQARELGLVNHAVAQNEegnaAYHRALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIE 160
Cdd:PRK07657  154 GVGRAKELIYTGRRISAQEAKEIGLVEFVVPAHL----LEEKAIEIAEKIASNGPIAVRQAKEAISNGIQVDLHTGLQIE 229

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1039768216 161 QMCYAQNIPTQDRLEGMAAFREKRAPKFVGK 191
Cdd:PRK07657  230 KQAYEGTIPTKDRLEGLQAFKEKRKPMYKGE 260
CaiD COG1024
Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase ...
 5-185 3.57e-59

Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase/carnithine racemase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440647 [Multi-domain]  Cd Length: 249  Bit Score: 185.37  E-value: 3.57e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216   5 EVGTFVQRLRGLMSEIAAFPVPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVAL 84
Cdd:COG1024    73 EARAFARGLQRLFRALRRLPKPVIAAVNGAALGGGLELALACDLRIAAEDARFGLPEVRLGLIPGGGGTQRLPRLVGLAR 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  85 AKELIFTGRRLNGAQARELGLVNHAVAQNEegnaAYHRALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEQMCY 164
Cdd:COG1024   153 AKELLLTGRRIDAEEALELGLVNRVVPDDE----LLAAALALAARLAAGPPLALAATKRALNAALEAPLDEALELEAEAF 228

                         170       180
                  ....*....|....*....|.
gi 1039768216 165 AQNIPTQDRLEGMAAFREKRA 185
Cdd:COG1024   229 AELFASEDAREGIAAFLEKRK 249
PRK05809 PRK05809
short-chain-enoyl-CoA hydratase;
26-191 1.17e-53

short-chain-enoyl-CoA hydratase;


Pssm-ID: 180270 [Multi-domain]  Cd Length: 260  Bit Score: 171.47  E-value: 1.17e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  26 PTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQARELGL 105
Cdd:PRK05809   99 PVIAAINGFALGGGCELSMACDIRIASEKAKFGQPEVGLGITPGFGGTQRLARIVGPGKAKELIYTGDMINAEEALRIGL 178

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216 106 VNHAVAQNEEGNAAYhralALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEQMCYAQNIPTQDRLEGMAAFREKRA 185
Cdd:PRK05809  179 VNKVVEPEKLMEEAK----ALANKIAANAPIAVKLCKDAINRGMQVDIDTAVAIEAEDFGECFSTEDQTEGMTAFVEKRE 254


                  ....*.
gi 1039768216 186 PKFVGK 191
Cdd:PRK05809  255 KNFKNK 260
PRK09674 PRK09674
enoyl-CoA hydratase-isomerase; Provisional
 6-191 1.49e-46

enoyl-CoA hydratase-isomerase; Provisional


Pssm-ID: 182026 [Multi-domain]  Cd Length: 255  Bit Score: 153.38  E-value: 1.49e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216   6 VGTFVQRLRGLMSEIAAFPVPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALA 85
Cdd:PRK09674   74 AATLNDPRPQLWQRLQAFNKPLIAAVNGYALGAGCELALLCDIVIAGENARFGLPEITLGIMPGAGGTQRLIRSVGKSLA 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  86 KELIFTGRRLNGAQARELGLVNHaVAQNEegnAAYHRALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEQMCYA 165
Cdd:PRK09674  154 SQMVLTGESITAQQAQQAGLVSE-VFPPE---LTLERALQLASKIARHSPLALRAAKQALRQSQEVDLQAGLAQERQLFT 229

                         170       180
                  ....*....|....*....|....*.
gi 1039768216 166 QNIPTQDRLEGMAAFREKRAPKFVGK 191
Cdd:PRK09674  230 LLAATEDRHEGISAFLEKRTPDFKGR 255
PRK07658 PRK07658
enoyl-CoA hydratase; Provisional
 16-191 2.82e-44

enoyl-CoA hydratase; Provisional


Pssm-ID: 181070 [Multi-domain]  Cd Length: 257  Bit Score: 147.47  E-value: 2.82e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  16 LMSEIAAFPVPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRL 95
Cdd:PRK07658   86 TFERVEKFSKPVIAAIHGAALGGGLELAMSCHIRFATESAKLGLPELNLGLIPGFAGTQRLPRYVGKAKALEMMLTSEPI 165

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  96 NGAQARELGLVNHAVAQNEegnaAYHRALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEQMCYAQNIPTQDRLE 175
Cdd:PRK07658  166 TGAEALKWGLVNGVFPEET----LLDDAKKLAKKIAGKSPATTRAVLELLQTTKSSSYYEGVKREAKIFGEVFTSEDAKE 241

                         170
                  ....*....|....*.
gi 1039768216 176 GMAAFREKRAPKFVGK 191
Cdd:PRK07658  242 GVQAFLEKRKPSFSGK 257
PRK06494 PRK06494
enoyl-CoA hydratase; Provisional
 26-191 8.68e-43

enoyl-CoA hydratase; Provisional


Pssm-ID: 180591 [Multi-domain]  Cd Length: 259  Bit Score: 143.64  E-value: 8.68e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  26 PTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQARELGL 105
Cdd:PRK06494   96 PIIAAVNGVAMGGGFELALACDLIVAAENATFALPEPRVGLAALAGGLHRLPRQIGLKRAMGMILTGRRVTAREGLELGF 175

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216 106 VNHAVAQnEEGNAAyhrALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAiEQMCY---AQNIPTQDRLEGMAAFRE 182
Cdd:PRK06494  176 VNEVVPA-GELLAA---AERWADDILACSPLSIRASKQAVYRGLEVSLEEAIT-AQRDYpavEARRASQDYIEGPKAFAE 250


                  ....*....
gi 1039768216 183 KRAPKFVGK 191
Cdd:PRK06494  251 KRPPRWKGR 259
PRK09076 PRK09076
enoyl-CoA hydratase; Provisional
 20-186 2.32e-42

enoyl-CoA hydratase; Provisional


Pssm-ID: 236373 [Multi-domain]  Cd Length: 258  Bit Score: 142.37  E-value: 2.32e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  20 IAAFPVPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQ 99
Cdd:PRK09076   91 LSAFRGVSIAAINGYAMGGGLECALACDIRIAEEQAQMALPEASVGLLPCAGGTQNLPWLVGEGWAKRMILCGERVDAAT 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216 100 ARELGLVNHAVAQNEegnaAYHRALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEQMCYAQNIPTQDRLEGMAA 179
Cdd:PRK09076  171 ALRIGLVEEVVEKGE----AREAALALAQKVANQSPSAVAACKTLIQAARNGPRAAALALERELFVDLFDTEDQREGVNA 246


                  ....*..
gi 1039768216 180 FREKRAP 186
Cdd:PRK09076  247 FLEKRAP 253
crotonase-like cd06558
Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse ...
 2-130 1.77e-41

Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.


Pssm-ID: 119339 [Multi-domain]  Cd Length: 195  Bit Score: 138.46  E-value: 1.77e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216   2 SDVEVGTFVQRLRGLMSEIAAFPVPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLG 81
Cdd:cd06558    71 AGEEARAFIRELQELLRALLRLPKPVIAAVNGAALGGGLELALACDIRIAAEDAKFGLPEVKLGLVPGGGGTQRLPRLVG 150

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1039768216  82 VALAKELIFTGRRLNGAQARELGLVNHAVAQNEegnaAYHRALALAQEI 130
Cdd:cd06558   151 PARARELLLTGRRISAEEALELGLVDEVVPDEE----LLAAALELARRL 195
PRK06688 PRK06688
enoyl-CoA hydratase; Provisional
 20-191 2.51e-40

enoyl-CoA hydratase; Provisional


Pssm-ID: 235852 [Multi-domain]  Cd Length: 259  Bit Score: 137.31  E-value: 2.51e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  20 IAAFPVPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQ 99
Cdd:PRK06688   92 IAALPKPVVAAVNGPAVGVGVSLALACDLVYASESAKFSLPFAKLGLCPDAGGSALLPRLIGRARAAEMLLLGEPLSAEE 171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216 100 ARELGLVNHAVAqNEEGNAAyhrALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEQMCYAQNIPTQDRLEGMAA 179
Cdd:PRK06688  172 ALRIGLVNRVVP-AAELDAE---ADAQAAKLAAGPASALRYTKRAINAATLTELEEALAREAAGFGRLLRTPDFREGATA 247

                         170
                  ....*....|..
gi 1039768216 180 FREKRAPKFVGK 191
Cdd:PRK06688  248 FIEKRKPDFTGF 259
ECH_1 pfam00378
Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: ...
 16-191 4.79e-40

Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: enoyl-CoA hydratase, napthoate synthase, carnitate racemase, 3-hydroxybutyryl-CoA dehydratase and dodecanoyl-CoA delta-isomerase.


Pssm-ID: 395302 [Multi-domain]  Cd Length: 251  Bit Score: 136.34  E-value: 4.79e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  16 LMSEIAAFPVPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRL 95
Cdd:pfam00378  80 LWTLLYTCPKPVIAAVNGYAIGGGCELALACDIIIAADNASFGLNETKLGIIPGAGGTDRLPRIIGHSKAMEMLLLGRRI 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  96 NGAQARELGLVNHAVAQNEegnaAYHRALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEQMCYAQNIPTQDRLE 175
Cdd:pfam00378 160 SAQEALKWGLVDKVVPEDQ----LLDEARELAEKLAEKSPAALAQLKKALNAKLEDALPTQLEAEARLFYSTFSKDDIIE 235

                         170
                  ....*....|....*.
gi 1039768216 176 GMAAFREKRAPKFVGK 191
Cdd:pfam00378 236 GLQAFLEKRKPPWEDQ 251
PRK05862 PRK05862
enoyl-CoA hydratase; Provisional
 19-188 3.05e-39

enoyl-CoA hydratase; Provisional


Pssm-ID: 180295 [Multi-domain]  Cd Length: 257  Bit Score: 134.40  E-value: 3.05e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  19 EIAAFPVPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGA 98
Cdd:PRK05862   89 KVARIRKPVIAAVAGYALGGGCELAMMCDIIIAADTAKFGQPEIKLGVLPGMGGSQRLTRAVGKAKAMDLCLTGRMMDAA 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  99 QARELGLVNHAVAQNEegnaAYHRALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEQMCYAQNIPTQDRLEGMA 178
Cdd:PRK05862  169 EAERAGLVSRVVPADK----LLDEALAAATTIASFSLPAVMMAKEAVNRAYETTLAEGLLFERRLFHSLFATEDQKEGMA 244

                         170
                  ....*....|
gi 1039768216 179 AFREKRAPKF 188
Cdd:PRK05862  245 AFVEKRKPVF 254
PRK08138 PRK08138
enoyl-CoA hydratase; Provisional
 20-191 2.42e-38

enoyl-CoA hydratase; Provisional


Pssm-ID: 236162 [Multi-domain]  Cd Length: 261  Bit Score: 132.48  E-value: 2.42e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  20 IAAFPVPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQ 99
Cdd:PRK08138   94 IAQCPKPVIAAVNGYALGGGCELAMHADIIVAGESASFGQPEIKVGLMPGAGGTQRLVRAVGKFKAMRMALTGCMVPAPE 173

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216 100 ARELGLVNHAVAQNEegnaAYHRALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEQMCYAQNIPTQDRLEGMAA 179
Cdd:PRK08138  174 ALAIGLVSEVVEDEQ----TLPRALELAREIARMPPLALAQIKEVVLAGADAPLDAALALERKAFQLLFDSEDQKEGMDA 249

                         170
                  ....*....|..
gi 1039768216 180 FREKRAPKFVGK 191
Cdd:PRK08138  250 FLEKRKPAYKGK 261
PRK08252 PRK08252
crotonase/enoyl-CoA hydratase family protein;
26-191 3.92e-34

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 181325 [Multi-domain]  Cd Length: 254  Bit Score: 121.25  E-value: 3.92e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  26 PTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQARELGL 105
Cdd:PRK08252   93 PLIAAVEGYALAGGFELALACDLIVAARDAKFGLPEVKRGLVAAGGGLLRLPRRIPYHIAMELALTGDMLTAERAHELGL 172

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216 106 VNHAVaqneEGNAAYHRALALAQEILPQAPIAVRLGKVAIDRGMEVDiASGMAIEQMCYAQNIPT-QDRLEGMAAFREKR 184
Cdd:PRK08252  173 VNRLT----EPGQALDAALELAERIAANGPLAVAASKRIVVESGDWS-EDEMFARQRELIAPVFTsADAKEGATAFAEKR 247


                  ....*..
gi 1039768216 185 APKFVGK 191
Cdd:PRK08252  248 APVWTGK 254
PRK06127 PRK06127
enoyl-CoA hydratase; Provisional
 20-191 8.02e-34

enoyl-CoA hydratase; Provisional


Pssm-ID: 235705  Cd Length: 269  Bit Score: 120.97  E-value: 8.02e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  20 IAAFPVPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQ 99
Cdd:PRK06127  102 LADYAKPTIACIRGYCIGGGMGIALACDIRIAAEDSRFGIPAARLGLGYGYDGVKNLVDLVGPSAAKDLFYTARRFDAAE 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216 100 ARELGLVNHAVAQNEEGNAAYHRALALAQeilpQAPIAVRLGKVAIDR----GMEVDIASGMAIEQMCYAqnipTQDRLE 175
Cdd:PRK06127  182 ALRIGLVHRVTAADDLETALADYAATIAG----NAPLTLRAAKRAIAEllkdEPERDMAACQALVAACFD----SEDYRE 253

                         170
                  ....*....|....*.
gi 1039768216 176 GMAAFREKRAPKFVGK 191
Cdd:PRK06127  254 GRAAFMEKRKPVFKGR 269
PRK05980 PRK05980
crotonase/enoyl-CoA hydratase family protein;
3-188 6.25e-33

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 180335 [Multi-domain]  Cd Length: 260  Bit Score: 118.32  E-value: 6.25e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216   3 DVEVGTFVQRLRGLMSEIAAFPVPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGV 82
Cdd:PRK05980   79 DVALRDFVRRGQAMTARLEAFPKPVIAAVNGLAFGGGCEITEAVHLAIASERALFAKPEIRLGMPPTFGGTQRLPRLAGR 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  83 ALAKELIFTGRRLNGAQARELGLVNHAVAQNEEGNAayhrALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEQM 162
Cdd:PRK05980  159 KRALELLLTGDAFSAERALEIGLVNAVVPHEELLPA----ARALARRIIRHSPVAVAAILTAVTRGLNLSIAEGLLIESE 234

                         170       180
                  ....*....|....*....|....*.
gi 1039768216 163 CYAQNIPTQDRLEGMAAFREKRAPKF 188
Cdd:PRK05980  235 QFARMAGSADLREGLAAWIERRRPAY 260
fadJ PRK11154
fatty acid oxidation complex subunit alpha FadJ;
16-112 2.54e-32

fatty acid oxidation complex subunit alpha FadJ;


Pssm-ID: 236864 [Multi-domain]  Cd Length: 708  Bit Score: 121.93  E-value: 2.54e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  16 LMSEIAAFPVPTIAAMDGFALGGGLELALACDLRIAASSA--VMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGR 93
Cdd:PRK11154   93 LFAEIEALPIPVVAAIHGACLGGGLELALACHYRVCTDDPktVLGLPEVQLGLLPGSGGTQRLPRLIGVSTALDMILTGK 172

                          90
                  ....*....|....*....
gi 1039768216  94 RLNGAQARELGLVNHAVAQ 112
Cdd:PRK11154  173 QLRAKQALKLGLVDDVVPH 191
PRK09245 PRK09245
crotonase/enoyl-CoA hydratase family protein;
25-191 4.43e-31

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 181723  Cd Length: 266  Bit Score: 113.53  E-value: 4.43e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  25 VPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQARELG 104
Cdd:PRK09245  104 VPVIAAVNGPAIGAGCDLACMCDIRIASETARFAESFVKLGLIPGDGGAWLLPRIIGMARAAEMAFTGDAIDAATALEWG 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216 105 LVNHAVAQNEegnaAYHRALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEQMCYAQNIPTQDRLEGMAAFREKR 184
Cdd:PRK09245  184 LVSRVVPADQ----LLPAARALAERIAANPPHALRLTKRLLREGQHASLDTLLELSAAYQALAHHTADHREAVDAFLEKR 259


                  ....*..
gi 1039768216 185 APKFVGK 191
Cdd:PRK09245  260 PPVFTGR 266
PRK03580 PRK03580
crotonobetainyl-CoA hydratase;
17-191 1.25e-30

crotonobetainyl-CoA hydratase;


Pssm-ID: 179599 [Multi-domain]  Cd Length: 261  Bit Score: 112.48  E-value: 1.25e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  17 MSEIAAFPVPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLN 96
Cdd:PRK03580   87 LTEIFDLDKPVIAAVNGYAFGGGFELALAADFIVCADNASFALPEAKLGIVPDSGGVLRLPKRLPPAIANEMVMTGRRMD 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  97 GAQARELGLVNHAVAQNEegnaAYHRALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEQMCYAQNIP----TQD 172
Cdd:PRK03580  167 AEEALRWGIVNRVVPQAE----LMDRARELAQQLVNSAPLAIAALKEIYRETSEMPVEEAYRYIRSGVLKHYPsvlhSED 242

                         170
                  ....*....|....*....
gi 1039768216 173 RLEGMAAFREKRAPKFVGK 191
Cdd:PRK03580  243 ALEGPRAFAEKRDPVWKGR 261
PRK07509 PRK07509
crotonase/enoyl-CoA hydratase family protein;
24-189 3.00e-30

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 181008 [Multi-domain]  Cd Length: 262  Bit Score: 111.51  E-value: 3.00e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  24 PVPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQAREL 103
Cdd:PRK07509  102 PVPVIAALEGVCFGGGLQIALGADIRIAAPDTKLSIMEAKWGLVPDMAGTVSLRGLVRKDVARELTYTARVFSAEEALEL 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216 104 GLVNHAVAQNEEgnaayhRALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEQMCYAQNIPTQDRLEGMAAFREK 183
Cdd:PRK07509  182 GLVTHVSDDPLA------AALALAREIAQRSPDAIAAAKRLINRSWTASVRALLARESVEQIRLLLGKNQKIAVKAQMKK 255


                  ....*.
gi 1039768216 184 RAPKFV 189
Cdd:PRK07509  256 RAPKFL 261
PRK07511 PRK07511
enoyl-CoA hydratase; Provisional
 13-190 4.14e-30

enoyl-CoA hydratase; Provisional


Pssm-ID: 181009 [Multi-domain]  Cd Length: 260  Bit Score: 110.86  E-value: 4.14e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  13 LRGLMSEIAAFPVPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTG 92
Cdd:PRK07511   87 LHDWIRAIRAFPKPVIAAVEGAAAGAGFSLALACDLLVAARDAKFVMAYVKVGLTPDGGGSWFLARALPRQLATELLLEG 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  93 RRLNGAQARELGLVNHAVaqneEGNAAYHRALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEQMCYAQNIPTQD 172
Cdd:PRK07511  167 KPISAERLHALGVVNRLA----EPGQALAEALALADQLAAGSPNALARIKSLIADAPEATLAAQLEAERDHFVASLHHAD 242

                         170
                  ....*....|....*...
gi 1039768216 173 RLEGMAAFREKRAPKFVG 190
Cdd:PRK07511  243 ALEGIAAFLEKRAPDYKR 260
PRK06142 PRK06142
crotonase/enoyl-CoA hydratase family protein;
10-190 1.10e-28

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 235714  Cd Length: 272  Bit Score: 107.37  E-value: 1.10e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  10 VQRLRGLMSEIAAFPVPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELI 89
Cdd:PRK06142   95 ILRLQAAINAVADCRKPVIAAVQGWCIGGGVDLISACDMRYASADAKFSVREVDLGMVADVGSLQRLPRIIGDGHLRELA 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  90 FTGRRLNGAQARELGLVNHAVAQNEEGNAAyhrALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEQMCYAQNIP 169
Cdd:PRK06142  175 LTGRDIDAAEAEKIGLVNRVYDDADALLAA---AHATAREIAAKSPLAVRGTKEVLDYMRDHRVADGLRYVATWNAAMLP 251

                         170       180
                  ....*....|....*....|.
gi 1039768216 170 TQDRLEGMAAFREKRAPKFVG 190
Cdd:PRK06142  252 SKDLTEAIAAHMEKRPPEFTG 272
PRK07799 PRK07799
crotonase/enoyl-CoA hydratase family protein;
26-191 1.49e-27

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 181122 [Multi-domain]  Cd Length: 263  Bit Score: 104.41  E-value: 1.49e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  26 PTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQARELGL 105
Cdd:PRK07799  102 PLIAAVEGPAIAGGTEILQGTDIRVAGESAKFGISEAKWSLFPMGGSAVRLVRQIPYTVACDLLLTGRHITAAEAKEIGL 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216 106 VNHAVAQNEegnaAYHRALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEQMCYAQNIPTQDRLEGMAAFREKRA 185
Cdd:PRK07799  182 IGHVVPDGQ----ALDKALELAELINANGPLAVQAILRTIRETEGMHENEAFKIDTKIGIPVFLSEDAKEGPRAFAEKRA 257


                  ....*.
gi 1039768216 186 PKFVGK 191
Cdd:PRK07799  258 PNFQGR 263
fadB PRK11730
fatty acid oxidation complex subunit alpha FadB;
1-157 2.07e-27

fatty acid oxidation complex subunit alpha FadB;


Pssm-ID: 183293 [Multi-domain]  Cd Length: 715  Bit Score: 108.03  E-value: 2.07e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216   1 MSDVEVGTFVQRLRGLMSEIAAFPVPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCL 80
Cdd:PRK11730   79 APEEELSQWLHFANSIFNRLEDLPVPTVAAINGYALGGGCECVLATDYRVASPDARIGLPETKLGIMPGFGGTVRLPRLI 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  81 GVALAKELIFTGRRLNGAQARELGLVNHAVAQNEEGNAAYHRA-LALAQEILPQAPIAVRLGKV---AIDRGMEVDIASG 156
Cdd:PRK11730  159 GADNALEWIAAGKDVRAEDALKVGAVDAVVAPEKLQEAALALLkQAIAGKLDWKARRQPKLEPLklsKIEAMMSFTTAKG 238


                  .
gi 1039768216 157 M 157
Cdd:PRK11730  239 M 239
PRK06190 PRK06190
enoyl-CoA hydratase; Provisional
 12-182 3.66e-27

enoyl-CoA hydratase; Provisional


Pssm-ID: 235733  Cd Length: 258  Bit Score: 103.13  E-value: 3.66e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  12 RLRGLMSEIAAFPVPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFT 91
Cdd:PRK06190   82 ALPNPSPAWPAMRKPVIGAINGAAVTGGLELALACDILIASERARFADTHARVGILPGWGLSVRLPQKVGIGRARRMSLT 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  92 GRRLNGAQARELGLVNHAVAQNEegnaAYHRALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEQmCYAQNIPTQ 171
Cdd:PRK06190  162 GDFLDAADALRAGLVTEVVPHDE----LLPRARRLAASIAGNNPAAVRALKASYDDGAAAQTGDALALEA-EAARAHNRS 236

                         170
                  ....*....|.
gi 1039768216 172 DRLEGMAAFRE 182
Cdd:PRK06190  237 VSPDGIAARRE 247
PRK06144 PRK06144
enoyl-CoA hydratase; Provisional
 12-191 4.69e-27

enoyl-CoA hydratase; Provisional


Pssm-ID: 180424 [Multi-domain]  Cd Length: 262  Bit Score: 103.15  E-value: 4.69e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  12 RLRGLMSEIAAFPVPTIAAMDGFALGGGLELALACDLRIAASSAVMGL-IETTRGLLPGAGGTQRLPRCLGVALAKELIF 90
Cdd:PRK06144   90 RIDRVLGALEQLRVPTIAAIAGACVGGGAAIAAACDLRIATPSARFGFpIARTLGNCLSMSNLARLVALLGAARVKDMLF 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  91 TGRRLNGAQARELGLVNHAVAQNEEGNaayhRALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEQMCYAqnipT 170
Cdd:PRK06144  170 TARLLEAEEALAAGLVNEVVEDAALDA----RADALAELLAAHAPLTLRATKEALRRLRREGLPDGDDLIRMCYM----S 241

                         170       180
                  ....*....|....*....|.
gi 1039768216 171 QDRLEGMAAFREKRAPKFVGK 191
Cdd:PRK06144  242 EDFREGVEAFLEKRPPKWKGR 262
PRK11423 PRK11423
methylmalonyl-CoA decarboxylase; Provisional
 13-191 1.54e-25

methylmalonyl-CoA decarboxylase; Provisional


Pssm-ID: 236908 [Multi-domain]  Cd Length: 261  Bit Score: 98.95  E-value: 1.54e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  13 LRGLMSEIAAFPVPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTG 92
Cdd:PRK11423   85 LRQILRMIQKFPKPVIAMVEGSVWGGAFELIMSCDLIIAASTSTFAMTPANLGVPYNLSGILNFTNDAGFHIVKEMFFTA 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  93 RRLNGAQARELGLVNHaVAQNEEGNAAyhrALALAQEILPQAPIAVRLGKvaidrgMEVDI---ASGMAIEQMCYAQNI- 168
Cdd:PRK11423  165 SPITAQRALAVGILNH-VVEVEELEDF---TLQMAHHISEKAPLAIAVIK------EQLRVlgeAHPMNPDEFERIQGLr 234

                         170       180
                  ....*....|....*....|....*..
gi 1039768216 169 ----PTQDRLEGMAAFREKRAPKFVGK 191
Cdd:PRK11423  235 ravyDSEDYQEGMNAFLEKRKPVFVGH 261
PRK06563 PRK06563
crotonase/enoyl-CoA hydratase family protein;
26-191 1.27e-24

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 180625 [Multi-domain]  Cd Length: 255  Bit Score: 96.57  E-value: 1.27e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  26 PTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQARELGL 105
Cdd:PRK06563   94 PLVVAVQGYCLTLGIELMLAADIVVAADNTRFAQLEVQRGILPFGGATLRFPQAAGWGNAMRYLLTGDEFDAQEALRLGL 173

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216 106 VNHAVAQNEEgnaaYHRALALAQEILPQAPIAVRL----GKVAIDRGMEVDIASGMAIEQMCYAqnipTQDRLEGMAAFR 181
Cdd:PRK06563  174 VQEVVPPGEQ----LERAIELAERIARAAPLGVQAtlasARAAVREGEAAAAAQLPPELRPLFT----SEDAKEGVQAFL 245

                         170
                  ....*....|
gi 1039768216 182 EKRAPKFVGK 191
Cdd:PRK06563  246 ERRPARFKGR 255
PLN02888 PLN02888
enoyl-CoA hydratase
 25-187 1.36e-24

enoyl-CoA hydratase


Pssm-ID: 215480  Cd Length: 265  Bit Score: 96.74  E-value: 1.36e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  25 VPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQARELG 104
Cdd:PLN02888  100 KPIIGAINGFAITAGFEIALACDILVASRGAKFIDTHAKFGIFPSWGLSQKLSRIIGANRAREVSLTAMPLTAETAERWG 179

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216 105 LVNHAVAQNEegnaAYHRALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEQ---MCYAQNIpTQDRLEGMAAFR 181
Cdd:PLN02888  180 LVNHVVEESE----LLKKAREVAEAIIKNNQGMVLRYKSVINDGLKLDLGHALQLEKeraHDYYNGM-TKEQFQKMQEFI 254


                  ....*.
gi 1039768216 182 EKRAPK 187
Cdd:PLN02888  255 AGRSSK 260
PRK06210 PRK06210
enoyl-CoA hydratase; Provisional
 22-191 4.23e-24

enoyl-CoA hydratase; Provisional


Pssm-ID: 180472  Cd Length: 272  Bit Score: 95.54  E-value: 4.23e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  22 AFPVPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQAR 101
Cdd:PRK06210  106 ALRKPVIAAINGACAGIGLTHALMCDVRFAADGAKFTTAFARRGLIAEHGISWILPRLVGHANALDLLLSARTFYAEEAL 185

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216 102 ELGLVNHAVAQNEEGNAAYHRALALAQEILPqAPIAVRLGKVAIDRGMEVDIASGMAIEQMcyAQNIPTQDRLEGMAAFR 181
Cdd:PRK06210  186 RLGLVNRVVPPDELMERTLAYAEDLARNVSP-ASMAVIKRQLYEDAFQTLAEATARANREM--HESLQRPDFIEGVASFL 262

                         170
                  ....*....|
gi 1039768216 182 EKRAPKFVGK 191
Cdd:PRK06210  263 EKRPPRFPGL 272
PRK06495 PRK06495
enoyl-CoA hydratase/isomerase family protein;
26-191 1.44e-23

enoyl-CoA hydratase/isomerase family protein;


Pssm-ID: 168580 [Multi-domain]  Cd Length: 257  Bit Score: 93.61  E-value: 1.44e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  26 PTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLlpgAGGTQRLPRCLGVALAKELIFTGRRLNGAQARELGL 105
Cdd:PRK06495   99 PVIAAVNGPALGAGLGLVASCDIIVASENAVFGLPEIDVGL---AGGGKHAMRLFGHSLTRRMMLTGYRVPAAELYRRGV 175

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216 106 VNHAVAQNEEGNAayhrALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEQMCYAQNIPTQDRLEGMAAFREKRA 185
Cdd:PRK06495  176 IEACLPPEELMPE----AMEIAREIASKSPLATRLAKDALNTIENMSLRDGYRYEQDITAKLAKTEDAKEAQRAFLEKRP 251


                  ....*.
gi 1039768216 186 PKFVGK 191
Cdd:PRK06495  252 PVFKGR 257
PRK06143 PRK06143
enoyl-CoA hydratase; Provisional
 9-184 3.00e-23

enoyl-CoA hydratase; Provisional


Pssm-ID: 180423  Cd Length: 256  Bit Score: 92.79  E-value: 3.00e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216   9 FVQRLRGLMSEIAAFPVPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGlLPGAGGTQRLPRCLGVALAKEL 88
Cdd:PRK06143   85 FISRLRDLCDAVRHFPVPVIARIPGWCLGGGLELAAACDLRIAAHDAQFGMPEVRVG-IPSVIHAALLPRLIGWARTRWL 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  89 IFTGRRLNGAQARELGLVnHAVAQNEEGNAAYHRalaLAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEQMCYAQNI 168
Cdd:PRK06143  164 LLTGETIDAAQALAWGLV-DRVVPLAELDAAVER---LAASLAGCGPQALRQQKRLLREWEDMPLDVAIDDSVAEFGAAF 239

                         170
                  ....*....|....*.
gi 1039768216 169 PTQDRLEGMAAFREKR 184
Cdd:PRK06143  240 LTGEPQRHMAAFLNRK 255
PRK09120 PRK09120
p-hydroxycinnamoyl CoA hydratase/lyase; Validated
 11-187 5.27e-23

p-hydroxycinnamoyl CoA hydratase/lyase; Validated


Pssm-ID: 236383  Cd Length: 275  Bit Score: 92.76  E-value: 5.27e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  11 QRLRglmseiaAFPVPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIF 90
Cdd:PRK09120   98 RRLR-------WYQKPTIAMVNGWCFGGGFSPLVACDLAIAADEAQFGLSEINWGIPPGGGVSKAMADTVGHRDALYYIM 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  91 TGRRLNGAQARELGLVNHAV--AQNEEgnaayhRALALAQEILPQAPIAVRLGKVAIDRGMEVDIASG-----MAIEQMC 163
Cdd:PRK09120  171 TGETFTGRKAAEMGLVNESVplAQLRA------RTRELAAKLLEKNPVVLRAAKDGFKRVRELTWDQAedylyAKLEQAN 244

                         170       180
                  ....*....|....*....|....
gi 1039768216 164 YAQniPTQDRLEGMAAFREKRAPK 187
Cdd:PRK09120  245 SLD--PEGGREEGLKQFLDDKSYK 266
PRK08150 PRK08150
crotonase/enoyl-CoA hydratase family protein;
24-187 7.50e-23

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 181254  Cd Length: 255  Bit Score: 91.62  E-value: 7.50e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  24 PVPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQAREL 103
Cdd:PRK08150   92 RVPVIAALHGAVVGGGLELASAAHIRVADESTYFALPEGQRGIFVGGGGSVRVPRLIGVARMTDMMLTGRVYDAQEGERL 171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216 104 GLVNHAVAQNEegnaAYHRALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEQMCYAQNIPTQDRLEGMAAFREK 183
Cdd:PRK08150  172 GLAQYLVPAGE----ALDKAMELARRIAQNAPLTNFAVLNALPRIADMSADDGLFVESLMAAVAQSAPEAKERLRAFLEK 247


                  ....
gi 1039768216 184 RAPK 187
Cdd:PRK08150  248 KAAK 251
PRK05869 PRK05869
enoyl-CoA hydratase; Validated
 1-146 1.03e-22

enoyl-CoA hydratase; Validated


Pssm-ID: 235632 [Multi-domain]  Cd Length: 222  Bit Score: 90.67  E-value: 1.03e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216   1 MSDVEVGTFVQRLRGLMSEIAAFPVPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCL 80
Cdd:PRK05869   76 LSAQEADTAARVRQQAVDAVAAIPKPTVAAITGYALGAGLTLALAADWRVSGDNVKFGATEILAGLAPSGDGMARLTRAA 155

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039768216  81 GVALAKELIFTGRRLNGAQARELGLVNHAVAQNEegnaAYHRALALAQEILPQAPIAVRLGKVAID 146
Cdd:PRK05869  156 GPSRAKELVFSGRFFDAEEALALGLIDEMVAPDD----VYDAAAAWARRFLDGPPHALAAAKAGIS 217
fa_ox_alpha_mit TIGR02441
fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of ...
 5-147 1.71e-22

fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of mitochondrial multifunctional fatty acid degradation enzyme complex. Subunit activities include: enoyl-CoA hydratase (EC 4.2.1.17) _ 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35). Some characterization in human (SP:P40939), pig (SP:Q29554), and rat (SP:Q64428). The beta subunit has activity: acetyl-CoA C-acyltransferase (EC 2.3.1.16).


Pssm-ID: 131494 [Multi-domain]  Cd Length: 737  Bit Score: 94.13  E-value: 1.71e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216   5 EVGTFVQRLRGLMSEIAAFPVPTIAAMDGFALGGGLELALACDLRIAA--SSAVMGLIETTRGLLPGAGGTQRLPRCLGV 82
Cdd:TIGR02441  89 EVTQLSQEGQEMFERIEKSQKPIVAAISGSCLGGGLELALACHYRIATkdRKTLLGLPEVMLGLLPGAGGTQRLPKLTGV 168

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039768216  83 ALAKELIFTGRRLNGAQARELGLVNHAVAQNEEG-NAAYHRALALAQEILPQAPIAVRLGKVAIDR 147
Cdd:TIGR02441 169 PAALDMMLTGKKIRADRAKKMGIVDQLVDPLGPGlKPAEENTIEYLEEVAVKFAQGLANGKLSINR 234
PRK08140 PRK08140
enoyl-CoA hydratase; Provisional
 16-191 1.96e-22

enoyl-CoA hydratase; Provisional


Pssm-ID: 236163  Cd Length: 262  Bit Score: 90.74  E-value: 1.96e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  16 LMSEIAAFPVPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRL 95
Cdd:PRK08140   91 LVRRLRALPLPVIAAVNGVAAGAGANLALACDIVLAARSASFIQAFVKIGLVPDSGGTWFLPRLVGMARALGLALLGEKL 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  96 NGAQARELGLVNHAVaqneEGNAAYHRALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEQMCYAQNIPTQDRLE 175
Cdd:PRK08140  171 SAEQAEQWGLIWRVV----DDAALADEAQQLAAHLATQPTRGLALIKQAMNASATNTLDAQLDLERDLQREAGRSADYAE 246

                         170
                  ....*....|....*.
gi 1039768216 176 GMAAFREKRAPKFVGK 191
Cdd:PRK08140  247 GVSAFLEKRAPRFTGR 262
menB TIGR01929
naphthoate synthase (dihydroxynaphthoic acid synthetase); This model represents an enzyme, ...
 10-188 3.00e-22

naphthoate synthase (dihydroxynaphthoic acid synthetase); This model represents an enzyme, naphthoate synthase (dihydroxynaphthoic acid synthetase), which is involved in the fifth step of the menaquinone biosynthesis pathway. Together with o-succinylbenzoate-CoA ligase (menE: TIGR01923), this enzyme takes 2-succinylbenzoate and converts it into 1,4-di-hydroxy-2-naphthoate. Included above the trusted cutoff are two enzymes from Arabadopsis thaliana and one from Staphylococcus aureus which are identified as putative enoyl-CoA hydratase/isomerases. These enzymes group with the naphthoate synthases when building a tree and when doing BLAST searches. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 200143 [Multi-domain]  Cd Length: 259  Bit Score: 90.30  E-value: 3.00e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  10 VQRLrglmseIAAFPVPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELI 89
Cdd:TIGR01929  89 VQRQ------IRTCPKPVIAMVNGYAIGGGHVLHMMCDLTIAAENARFGQTGPKVGSFDGGYGSSYMARIVGQKKAREIW 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  90 FTGRRLNGAQARELGLVNHAVAQNEEGNAayhrALALAQEILPQAPIAVRLGKVAIDrgMEVDIASGmaieQMCYAQNIP 169
Cdd:TIGR01929 163 FLCRQYDAKQALDMGLVNTVVPLADLEKE----TVRWCREILQKSPMAIRMLKAALN--ADCDGQAG----LQELAGNAT 232

                         170       180
                  ....*....|....*....|....
gi 1039768216 170 -----TQDRLEGMAAFREKRAPKF 188
Cdd:TIGR01929 233 mlfymTEEGQEGRNAFLEKRQPDF 256
PRK05995 PRK05995
enoyl-CoA hydratase; Provisional
 1-191 4.27e-22

enoyl-CoA hydratase; Provisional


Pssm-ID: 235664 [Multi-domain]  Cd Length: 262  Bit Score: 89.98  E-value: 4.27e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216   1 MSDVEVGTFVQRLRGLMSEIAAFPVPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPgaggTQRLP--- 77
Cdd:PRK05995   76 YSDDENRADARRLADMLRAIYRCPKPVIARVHGDAYAGGMGLVAACDIAVAADHAVFCLSEVRLGLIP----ATISPyvi 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  78 RCLGVALAKELIFTGRRLNGAQARELGLVNHAVAQnEEGNAAYHralALAQEILPQAPIAVRLGKVAIDrgmevDIAsGM 157
Cdd:PRK05995  152 RAMGERAARRYFLTAERFDAAEALRLGLVHEVVPA-EALDAKVD---ELLAALVANSPQAVRAGKRLVR-----DVA-GR 221

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1039768216 158 AIEQMCYAQnipTQDRL----------EGMAAFREKRAPKFVGK 191
Cdd:PRK05995  222 PIDAALIAD---TASRIalirateearEGVAAFLEKRKPAWRGR 262
PLN02664 PLN02664
enoyl-CoA hydratase/delta3,5-delta2,4-dienoyl-CoA isomerase
 26-188 1.68e-21

enoyl-CoA hydratase/delta3,5-delta2,4-dienoyl-CoA isomerase


Pssm-ID: 178269 [Multi-domain]  Cd Length: 275  Bit Score: 88.81  E-value: 1.68e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  26 PTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQARELGL 105
Cdd:PLN02664  113 PVIAAIHGACIGGGVDIVTACDIRYCSEDAFFSVKEVDLAITADLGTLQRLPSIVGYGNAMELALTGRRFSGSEAKELGL 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216 106 VNHAVAQNEEGNAAYHralALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEQMCYAQNIPTQDRLEGMAAFREKRA 185
Cdd:PLN02664  193 VSRVFGSKEDLDEGVR---LIAEGIAAKSPLAVTGTKAVLLRSRELSVEQGLDYVATWNSAMLVSDDLNEAVSAQIQKRK 269


                  ...
gi 1039768216 186 PKF 188
Cdd:PLN02664  270 PVF 272
PRK08259 PRK08259
crotonase/enoyl-CoA hydratase family protein;
26-134 4.22e-21

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 236205  Cd Length: 254  Bit Score: 87.26  E-value: 4.22e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  26 PTIAAMDGFALGGGLELALACDLRIAASSAVMG---------LIEttrgllpgaGGTQRLPRCLGVALAKELIFTGRRLN 96
Cdd:PRK08259   95 PVIAAVSGYAVAGGLELALWCDLRVAEEDAVFGvfcrrwgvpLID---------GGTVRLPRLIGHSRAMDLILTGRPVD 165

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1039768216  97 GAQARELGLVNHAVAQNEegnaAYHRALALAQEI--LPQA 134
Cdd:PRK08259  166 ADEALAIGLANRVVPKGQ----ARAAAEELAAELaaFPQT 201
PRK08139 PRK08139
enoyl-CoA hydratase; Validated
 16-186 1.01e-20

enoyl-CoA hydratase; Validated


Pssm-ID: 181249  Cd Length: 266  Bit Score: 86.15  E-value: 1.01e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  16 LMSEIAAFPVPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLL---PGAGgtqrLPRCLGVALAKELIFTG 92
Cdd:PRK08139   96 VMQAIVALPQPVIARVHGIATAAGCQLVASCDLAVAADTARFAVPGVNIGLFcstPMVA----LSRNVPRKQAMEMLLTG 171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  93 RRLNGAQARELGLVNHAVAQNEEGNAayhrALALAQEILPQAPIAVRLGKVAIDR--GMEVDIASGMAIEQMcyAQNIPT 170
Cdd:PRK08139  172 EFIDAATAREWGLVNRVVPADALDAA----VARLAAVIAAKSPAAVRIGKEAFYRqaEMPLADAYAYAGDVM--AENMMA 245

                         170
                  ....*....|....*.
gi 1039768216 171 QDRLEGMAAFREKRAP 186
Cdd:PRK08139  246 EDAEEGIDAFLEKRPP 261
PRK08260 PRK08260
enoyl-CoA hydratase; Provisional
 26-191 1.74e-20

enoyl-CoA hydratase; Provisional


Pssm-ID: 236206 [Multi-domain]  Cd Length: 296  Bit Score: 86.21  E-value: 1.74e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  26 PTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQARELGL 105
Cdd:PRK08260  115 PVIAAVNGPAVGVGATMTLAMDIRLASTAARFGFVFGRRGIVPEAASSWFLPRLVGLQTALEWVYSGRVFDAQEALDGGL 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216 106 VNHAVAQNEEGNAAYhralALAQEILPQ-APIAVRLGKVAIDRGMEVDI-ASGMAIEQMCYAQNIPTQDRLEGMAAFREK 183
Cdd:PRK08260  195 VRSVHPPDELLPAAR----ALAREIADNtSPVSVALTRQMMWRMAGADHpMEAHRVDSRAIYSRGRSGDGKEGVSSFLEK 270


                  ....*...
gi 1039768216 184 RAPKFVGK 191
Cdd:PRK08260  271 RPAVFPGK 278
PRK07854 PRK07854
enoyl-CoA hydratase; Provisional
 9-191 2.58e-19

enoyl-CoA hydratase; Provisional


Pssm-ID: 236115 [Multi-domain]  Cd Length: 243  Bit Score: 81.99  E-value: 2.58e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216   9 FVQRLRGLMSEIAAFPVPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKEL 88
Cdd:PRK07854   71 FPDALIEMLHAIDAAPVPVIAAINGPAIGAGLQLAMACDLRVVAPEAYFQFPVAKYGIALDNWTIRRLSSLVGGGRARAM 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  89 IFTGRRLNGAQARELGLVnhavaqNEEGNAAyhRALALAQEILPQAPIAVRLGKVAI--DRGMEVDIASGMAIEQMCYAq 166
Cdd:PRK07854  151 LLGAEKLTAEQALATGMA------NRIGTLA--DAQAWAAEIAGLAPLALQHAKRVLndDGAIEEAWPAHKELFDKAWA- 221

                         170       180
                  ....*....|....*....|....*
gi 1039768216 167 nipTQDRLEGMAAFREKRAPKFVGK 191
Cdd:PRK07854  222 ---SQDAIEAQVARIEKRPPKFQGA 243
MenB COG0447
1,4-Dihydroxy-2-naphthoyl-CoA synthase [Coenzyme transport and metabolism]; 1, ...
 10-188 4.53e-19

1,4-Dihydroxy-2-naphthoyl-CoA synthase [Coenzyme transport and metabolism]; 1,4-Dihydroxy-2-naphthoyl-CoA synthase is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440216  Cd Length: 281  Bit Score: 82.17  E-value: 4.53e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  10 VQRLrglmseIAAFPVPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELI 89
Cdd:COG0447   109 VQRL------IRFMPKPVIAMVAGWAIGGGHVLHVVCDLTIASENARFGQTGPDVGSFDAGYGSAYLARQVGQKKAREIW 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  90 FTGRRLNGAQARELGLVNHAV--AQNEEgnaayhRALALAQEILPQAPIAVRLGKVAIDrgMEVDiasGMAIEQ------ 161
Cdd:COG0447   183 FLCRQYSAQEALEMGLVNKVVphAELEE------EAVEWAREILEKSPTAIRMLKAAFN--ADDD---GLAGQQefagea 251

                         170       180
                  ....*....|....*....|....*....
gi 1039768216 162 --MCYAqnipTQDRLEGMAAFREKRAPKF 188
Cdd:COG0447   252 trLAYM----TDEAQEGRDAFLEKRKPDF 276
PRK08290 PRK08290
enoyl-CoA hydratase; Provisional
 23-187 1.18e-18

enoyl-CoA hydratase; Provisional


Pssm-ID: 236220 [Multi-domain]  Cd Length: 288  Bit Score: 81.16  E-value: 1.18e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  23 FPVPTIAAMDGFALGGGLELALACDLRIAASSAV-------MGliettrgllpgAGGTQRL--PRCLGVALAKELIFTGR 93
Cdd:PRK08290  117 LPKPTIAQVQGACIAGGLMLAWVCDLIVASDDAFfsdpvvrMG-----------IPGVEYFahPWELGPRKAKELLFTGD 185

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  94 RLNGAQARELGLVNHAVAQNEegnaAYHRALALAQEILPQAPIAVRLGKVAIDR-----GMEVDIASGMAIEQMCYAQNI 168
Cdd:PRK08290  186 RLTADEAHRLGMVNRVVPRDE----LEAETLELARRIAAMPPFGLRLTKRAVNQtldaqGFRAALDAVFDLHQLGHAHNA 261

                         170       180
                  ....*....|....*....|....*
gi 1039768216 169 PTQD------RLEGMAAFREKRAPK 187
Cdd:PRK08290  262 EVGGdrlggaDARGMADARKAAAAK 286
PRK05981 PRK05981
enoyl-CoA hydratase/isomerase;
16-191 1.41e-18

enoyl-CoA hydratase/isomerase;


Pssm-ID: 235661  Cd Length: 266  Bit Score: 80.55  E-value: 1.41e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  16 LMSEIAAFPVPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRL 95
Cdd:PRK05981   95 FLRRLRNLPCPIVTAVNGPAAGVGMSFALMGDLILCARSAYFLQAFRRIGLVPDGGSTWLLPRLVGKARAMELSLLGEKL 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  96 NGAQARELGLVNHAVAQNEegnaAYHRALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEqmCYAQNIP--TQDR 173
Cdd:PRK05981  175 PAETALQWGLVNRVVDDAE----LMAEAMKLAHELANGPTVALGLIRKLYWDSPENDFEEQLNLE--REAQRIAgkTEDF 248

                         170
                  ....*....|....*...
gi 1039768216 174 LEGMAAFREKRAPKFVGK 191
Cdd:PRK05981  249 KEGVGAFLQKRPAQFKGR 266
PRK08258 PRK08258
enoyl-CoA hydratase family protein;
24-190 3.18e-18

enoyl-CoA hydratase family protein;


Pssm-ID: 181329  Cd Length: 277  Bit Score: 79.63  E-value: 3.18e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  24 PVPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGlLPGA--GGTQRLPRCLGVALAKELIFTGRRLNGAQAR 101
Cdd:PRK08258  113 PQPIIAAVDGVCAGAGAILAMASDLRLGTPSAKTAFLFTRVG-LAGAdmGACALLPRIIGQGRASELLYTGRSMSAEEGE 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216 102 ELGLVNHAVAQNEegnaAYHRALALAQEILPQAPIAVRLGKVAIDrgMEVDIASGMAIEQMCYAQNI--PTQDRLEGMAA 179
Cdd:PRK08258  192 RWGFFNRLVEPEE----LLAEAQALARRLAAGPTFAHGMTKTMLH--QEWDMGLEEAIEAEAQAQAIcmQTEDFRRAYEA 265

                         170
                  ....*....|.
gi 1039768216 180 FREKRAPKFVG 190
Cdd:PRK08258  266 FVAKRKPVFEG 276
PRK07396 PRK07396
dihydroxynaphthoic acid synthetase; Validated
 10-188 6.23e-18

dihydroxynaphthoic acid synthetase; Validated


Pssm-ID: 180958 [Multi-domain]  Cd Length: 273  Bit Score: 78.78  E-value: 6.23e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  10 VQRLrglmseIAAFPVPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELI 89
Cdd:PRK07396   99 LQRL------IRTCPKPVIAMVAGYAIGGGHVLHLVCDLTIAADNAIFGQTGPKVGSFDGGYGASYLARIVGQKKAREIW 172

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  90 FTGRRLNGAQARELGLVNHAV--AQNEEgnaayhRALALAQEILPQAPIAVRLGKVAIDrgMEVDiasGMA-IEQMcyAQ 166
Cdd:PRK07396  173 FLCRQYDAQEALDMGLVNTVVplADLEK------ETVRWCREMLQNSPMALRCLKAALN--ADCD---GQAgLQEL--AG 239

                         170       180
                  ....*....|....*....|....*..
gi 1039768216 167 NIP-----TQDRLEGMAAFREKRAPKF 188
Cdd:PRK07396  240 NATmlfymTEEAQEGRNAFNEKRQPDF 266
PRK07659 PRK07659
enoyl-CoA hydratase; Provisional
 11-191 4.53e-17

enoyl-CoA hydratase; Provisional


Pssm-ID: 236073 [Multi-domain]  Cd Length: 260  Bit Score: 76.61  E-value: 4.53e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  11 QRLRGLMSEIA----AFPVPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAK 86
Cdd:PRK07659   81 DGVMNTISEIVvtlyTMPKLTISAIHGPAAGLGLSIALTADYVIADISAKLAMNFIGIGLIPDGGGHFFLQKRVGENKAK 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  87 ELIFTGRRLNGAQARELGLVNhAVAQNEEGNAAYHRALALAQEILpQAPIA-----VRLGKVAIDRGMEVDIASGMAIEQ 161
Cdd:PRK07659  161 QIIWEGKKLSATEALDLGLID-EVIGGDFQTAAKQKISEWLQKPL-KAMIEtkqiyCELNRSQLEQVLQLEKRAQYAMRQ 238

                         170       180       190
                  ....*....|....*....|....*....|
gi 1039768216 162 mcyaqnipTQDRLEGMAAFREKRAPKFVGK 191
Cdd:PRK07659  239 --------TADHKEGIRAFLEKRLPVFKGE 260
PRK07110 PRK07110
polyketide biosynthesis enoyl-CoA hydratase; Validated
 16-128 9.04e-17

polyketide biosynthesis enoyl-CoA hydratase; Validated


Pssm-ID: 235936  Cd Length: 249  Bit Score: 75.39  E-value: 9.04e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  16 LMSEIAAFPVPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRL 95
Cdd:PRK07110   86 LYSLALNCPIPVIAAMQGHAIGGGLVLGLYADIVVLSRESVYTANFMKYGFTPGMGATAILPEKLGLALGQEMLLTARYY 165

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1039768216  96 NGAQARELGLVNHAVAQNEEGNAAYHRALALAQ 128
Cdd:PRK07110  166 RGAELKKRGVPFPVLPRAEVLEKALELARSLAE 198
PRK07327 PRK07327
enoyl-CoA hydratase/isomerase family protein;
14-188 3.39e-16

enoyl-CoA hydratase/isomerase family protein;


Pssm-ID: 235991  Cd Length: 268  Bit Score: 74.29  E-value: 3.39e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  14 RGLMSEIAAFPVPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGR 93
Cdd:PRK07327   96 RDLVYNVINCDKPIVSAIHGPAVGAGLVAALLADISIAAKDARIIDGHTRLGVAAGDHAAIVWPLLCGMAKAKYYLLLCE 175

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  94 RLNGAQARELGLVNHAVAQNEegnaAYHRALALAQEILPQAPIAVRLGKVAID---RGMEVDIASGMAIEQMCYAqnipT 170
Cdd:PRK07327  176 PVSGEEAERIGLVSLAVDDDE----LLPKALEVAERLAAGSQTAIRWTKYALNnwlRMAGPTFDTSLALEFMGFS----G 247

                         170
                  ....*....|....*...
gi 1039768216 171 QDRLEGMAAFREKRAPKF 188
Cdd:PRK07327  248 PDVREGLASLREKRAPDF 265
PRK07468 PRK07468
crotonase/enoyl-CoA hydratase family protein;
24-191 4.24e-16

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 180987 [Multi-domain]  Cd Length: 262  Bit Score: 73.94  E-value: 4.24e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  24 PVPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRcLGVALAKELIFTGRRLNGAQAREL 103
Cdd:PRK07468  100 PKPLIGRIQGQAFGGGVGLISVCDVAIAVSGARFGLTETRLGLIPATISPYVVAR-MGEANARRVFMSARLFDAEEAVRL 178

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216 104 GLVNHAVAQnEEGNAAYHRALAlaqEILPQAPIAV-RLGKVAIDRGMEVDIAS-GMAIEQMcyAQNIPTQDRLEGMAAFR 181
Cdd:PRK07468  179 GLLSRVVPA-ERLDAAVEAEVT---PYLSCAPGAVaAAKALVRALGAPIDEAViDATIEAL--ADTWETEEAREGIAAFF 252

                         170
                  ....*....|
gi 1039768216 182 EKRAPKFVGK 191
Cdd:PRK07468  253 DKRAPAWRGG 262
ECH_2 pfam16113
Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: ...
 16-147 1.09e-15

Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: enoyl-CoA hydratase, napthoate synthase, carnitate racemase, 3-hydroxybutyryl-CoA dehydratase and dodecanoyl-CoA delta-isomerase. This family differs from pfam00378 in the structure of it's C-terminus.


Pssm-ID: 465024 [Multi-domain]  Cd Length: 331  Bit Score: 73.27  E-value: 1.09e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  16 LMSEIAAFPVPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRC---LGVALAkeliFTG 92
Cdd:pfam16113  80 LNYLIATYPKPYVALMDGIVMGGGVGLSVHGSFRVVTERTRFAMPETAIGLFPDVGGSYFLSRLpgeLGLYLA----LTG 155

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039768216  93 RRLNGAQARELGLVNHAV-------------AQNEEGNAAYHRALALAQEILPQAPIAVRLGKVAIDR 147
Cdd:pfam16113 156 ARLNGADALAAGLATHYVpsarlpaleealaALDWSDPADVDAVLAEFAEESDPPPSPLAAHREAIDR 223
PLN02921 PLN02921
naphthoate synthase
 12-188 5.74e-15

naphthoate synthase


Pssm-ID: 178509 [Multi-domain]  Cd Length: 327  Bit Score: 71.36  E-value: 5.74e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  12 RLR--GLMSEIAAFPVPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELI 89
Cdd:PLN02921  147 RLNvlDLQIQIRRLPKPVIAMVAGYAVGGGHILHMVCDLTIAADNAVFGQTGPKVGSFDAGYGSSIMARLVGQKKAREMW 226

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  90 FTGRRLNGAQARELGLVNHAV--AQNEEGNAAYHRalalaqEILPQAPIAVRLGKVAIDRGMevDIASGmaIEQMcyAQN 167
Cdd:PLN02921  227 FLARFYTASEALKMGLVNTVVplDELEGETVKWCR------EILRNSPTAIRVLKSALNAAD--DGHAG--LQEL--GGN 294

                         170       180
                  ....*....|....*....|....*.
gi 1039768216 168 IP-----TQDRLEGMAAFREKRAPKF 188
Cdd:PLN02921  295 ATllfygSEEGNEGRTAYLEGRAPDF 320
PRK07938 PRK07938
enoyl-CoA hydratase family protein;
24-145 1.08e-14

enoyl-CoA hydratase family protein;


Pssm-ID: 181174  Cd Length: 249  Bit Score: 69.62  E-value: 1.08e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  24 PVPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLprcLGVALAKELIFTGRRLNGAQAREL 103
Cdd:PRK07938   94 AVPVIAAVHGFCLGGGIGLVGNADVIVASDDATFGLPEVDRGALGAATHLQRL---VPQHLMRALFFTAATITAAELHHF 170

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1039768216 104 GLVnHAVAQNEEGNAAyhrALALAQEILPQAPIAVRLGKVAI 145
Cdd:PRK07938  171 GSV-EEVVPRDQLDEA---ALEVARKIAAKDTRVIRAAKEAL 208
PRK08321 PRK08321
1,4-dihydroxy-2-naphthoyl-CoA synthase;
10-188 1.30e-14

1,4-dihydroxy-2-naphthoyl-CoA synthase;


Pssm-ID: 181386  Cd Length: 302  Bit Score: 70.05  E-value: 1.30e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  10 VQRLrglmseIAAFPVPTIAAMDGFALGGGLELALACDLRIAASS-AVMGLIETTRGLLPGAGGTQRLPRCLGVALAKEL 88
Cdd:PRK08321  127 VQRL------IRFMPKVVIAVVPGWAAGGGHSLHVVCDLTLASREhARFKQTDADVGSFDGGYGSAYLARQVGQKFAREI 200

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  89 IFTGRRLNGAQARELGLVNHAVAQNEEGNAayhrALALAQEILPQAPIAVRLGKVA---IDRGM-EVDIASGMAIeQMCY 164
Cdd:PRK08321  201 FFLGRTYSAEEAHDMGAVNAVVPHAELETE----ALEWAREINGKSPTAMRMLKYAfnlTDDGLvGQQLFAGEAT-RLAY 275

                         170       180
                  ....*....|....*....|....
gi 1039768216 165 AqnipTQDRLEGMAAFREKRAPKF 188
Cdd:PRK08321  276 M----TDEAQEGRDAFLEKRDPDW 295
PRK05864 PRK05864
enoyl-CoA hydratase; Provisional
 26-189 1.46e-14

enoyl-CoA hydratase; Provisional


Pssm-ID: 168278 [Multi-domain]  Cd Length: 276  Bit Score: 69.86  E-value: 1.46e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  26 PTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGA-GGTQRLPRCLGVALAKELIFTGRRLNGAQARELG 104
Cdd:PRK05864  111 PVIAAVNGPAIGGGLCLALAADIRVASSSAYFRAAGINNGLTASElGLSYLLPRAIGSSRAFEIMLTGRDVDAEEAERIG 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216 105 LVNHAVAQNEEGNAAYhralALAQEILPQAPIAVRLGKVAIDRGMevDIASGMA-IEQMCYAQ---NIPTQDRLEGMAAF 180
Cdd:PRK05864  191 LVSRQVPDEQLLDTCY----AIAARMAGFSRPGIELTKRTLWSGL--DAASLEAhMQAEGLGQlfvRLLTANFEEAVAAR 264


                  ....*....
gi 1039768216 181 REKRAPKFV 189
Cdd:PRK05864  265 AEKRPPVFT 273
PRK08788 PRK08788
enoyl-CoA hydratase; Validated
 24-119 4.26e-14

enoyl-CoA hydratase; Validated


Pssm-ID: 236338  Cd Length: 287  Bit Score: 68.78  E-value: 4.26e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  24 PVPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQAREL 103
Cdd:PRK08788  121 GAISIALVQGDALGGGFEAALSHHTIIAERGAKMGFPEILFNLFPGMGAYSFLARRVGPKLAEELILSGKLYTAEELHDM 200

                          90
                  ....*....|....*.
gi 1039768216 104 GLVnHAVAQNEEGNAA 119
Cdd:PRK08788  201 GLV-DVLVEDGQGEAA 215
PRK06072 PRK06072
enoyl-CoA hydratase; Provisional
 28-190 1.63e-13

enoyl-CoA hydratase; Provisional


Pssm-ID: 168377 [Multi-domain]  Cd Length: 248  Bit Score: 66.73  E-value: 1.63e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  28 IAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRcLGVALAKELIFTGRRLNGAQARELGLVN 107
Cdd:PRK06072   93 ISAINGVTAGACIGIALSTDFKFASRDVKFVTAFQRLGLASDTGVAYFLLK-LTGQRFYEILVLGGEFTAEEAERWGLLK 171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216 108 haVAQNeegnaAYHRALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEQMCYAQNIPTQDRLEGMAAFREKRAPK 187
Cdd:PRK06072  172 --ISED-----PLSDAEEMANRISNGPFQSYIAAKRMINLVLYNDLEEFLEYESAIQGYLGKTEDFKEGISSFKEKREPK 244


                  ...
gi 1039768216 188 FVG 190
Cdd:PRK06072  245 FKG 247
PRK05870 PRK05870
enoyl-CoA hydratase; Provisional
 20-106 4.63e-13

enoyl-CoA hydratase; Provisional


Pssm-ID: 180298  Cd Length: 249  Bit Score: 65.52  E-value: 4.63e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  20 IAAFPVPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQ 99
Cdd:PRK05870   91 VASCPLPTIAAVNGAAVGAGLNLALAADVRIAGPKALFDARFQKLGLHPGGGATWMLQRAVGPQVARAALLFGMRFDAEA 170


                  ....*..
gi 1039768216 100 ARELGLV 106
Cdd:PRK05870  171 AVRHGLA 177
PRK05617 PRK05617
3-hydroxyisobutyryl-CoA hydrolase; Provisional
 20-114 5.80e-12

3-hydroxyisobutyryl-CoA hydrolase; Provisional


Pssm-ID: 235533 [Multi-domain]  Cd Length: 342  Bit Score: 62.92  E-value: 5.80e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  20 IAAFPVPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGvALAKELIFTGRRLNGAQ 99
Cdd:PRK05617   96 IARYPKPYIALMDGIVMGGGVGISAHGSHRIVTERTKMAMPETGIGFFPDVGGTYFLSRAPG-ALGTYLALTGARISAAD 174

                          90
                  ....*....|....*
gi 1039768216 100 ARELGLVNHAVAQNE 114
Cdd:PRK05617  175 ALYAGLADHFVPSAD 189
PRK05674 PRK05674
gamma-carboxygeranoyl-CoA hydratase; Validated
 11-186 1.28e-11

gamma-carboxygeranoyl-CoA hydratase; Validated


Pssm-ID: 168168  Cd Length: 265  Bit Score: 61.36  E-value: 1.28e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  11 QRLRGLMSEIAAFPVPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPgAGGTQRLPRCLGVALAKELIF 90
Cdd:PRK05674   88 RELAELMYNLYRLKIPTLAVVQGAAFGGALGLISCCDMAIGADDAQFCLSEVRIGLAP-AVISPFVVKAIGERAARRYAL 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  91 TGRRLNGAQARELGLVNHAVAQNEegnaAYHRALALAQEILPQAPIAVRLGKvaiDRGMEVDIAS-GMAIEQmcYAQNIP 169
Cdd:PRK05674  167 TAERFDGRRARELGLLAESYPAAE----LEAQVEAWIANLLLNSPQALRASK---DLLREVGDGElSPALRR--YCENAI 237

                         170       180
                  ....*....|....*....|..
gi 1039768216 170 TQDRL-----EGMAAFREKRAP 186
Cdd:PRK05674  238 ARIRVsaegqEGLRAFLEKRTP 259
PRK08272 PRK08272
crotonase/enoyl-CoA hydratase family protein;
26-110 3.95e-11

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 236213  Cd Length: 302  Bit Score: 60.44  E-value: 3.95e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  26 PTIAAMDGFALGGGLELALACDLRIAASSAVMGLIET-TRGLLPGAGGTQRlprcLGVALAKELIFTGRRLNGAQARELG 104
Cdd:PRK08272  129 PTVAKVHGYCVAGGTDIALHCDQVIAADDAKIGYPPTrVWGVPATGMWAYR----LGPQRAKRLLFTGDCITGAQAAEWG 204


                  ....*.
gi 1039768216 105 LVNHAV 110
Cdd:PRK08272  205 LAVEAV 210
PRK07827 PRK07827
enoyl-CoA hydratase family protein;
12-190 2.91e-10

enoyl-CoA hydratase family protein;


Pssm-ID: 236109 [Multi-domain]  Cd Length: 260  Bit Score: 57.77  E-value: 2.91e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  12 RLRGLMSEIAAFPVPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIfT 91
Cdd:PRK07827   89 EMTALLRAIVELPKPVIAAIDGHVRAGGFGLVGACDIVVAGPESTFALTEARIGVAPAIISLTLLPRLSPRAAARYYL-T 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  92 GRRLNGAQARELGLVNHAVAQNEEGNAAYHRALALAQeilPQAPIAV-RLGKVAIDRGMEVDiASGMAIEQmcyAQNIPT 170
Cdd:PRK07827  168 GEKFGAAEAARIGLVTAAADDVDAAVAALLADLRRGS---PQGLAESkALTTAAVLAGFDRD-AEELTEES---ARLFVS 240

                         170       180
                  ....*....|....*....|
gi 1039768216 171 QDRLEGMAAFREKRAPKFVG 190
Cdd:PRK07827  241 DEAREGMTAFLQKRPPRWAL 260
PRK06023 PRK06023
crotonase/enoyl-CoA hydratase family protein;
20-180 2.25e-09

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 168351  Cd Length: 251  Bit Score: 55.18  E-value: 2.25e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  20 IAAFPVPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQ 99
Cdd:PRK06023   93 LAEAEKPIVSGVDGLAIGIGTTIHLHCDLTFASPRSLFRTPFVDLALVPEAGSSLLAPRLMGHQRAFALLALGEGFSAEA 172

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216 100 ARELGLVNHAVAQneegNAAYHRALALAQEILPQAPIAVRLGKVAIdRGMEVDIASGMAIEQMCYAQNIPTQDRLEGMAA 179
Cdd:PRK06023  173 AQEAGLIWKIVDE----EAVEAETLKAAEELAAKPPQALQIARDLM-RGPREDILARIDEEAKHFAARLKSAEARAAFEA 247


                  .
gi 1039768216 180 F 180
Cdd:PRK06023  248 F 248
PLN02851 PLN02851
3-hydroxyisobutyryl-CoA hydrolase-like protein
 5-108 3.66e-09

3-hydroxyisobutyryl-CoA hydrolase-like protein


Pssm-ID: 178443 [Multi-domain]  Cd Length: 407  Bit Score: 54.99  E-value: 3.66e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216   5 EVGTFVQRLRGLMSEIAAFPVPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGT---QRLPRCLG 81
Cdd:PLN02851  119 ECKLFFENLYKFVYLQGTYLKPNVAIMDGITMGCGAGISIPGMFRVVTDKTVFAHPEVQMGFHPDAGASyylSRLPGYLG 198

                          90       100
                  ....*....|....*....|....*..
gi 1039768216  82 VALAkeliFTGRRLNGAQARELGLVNH 108
Cdd:PLN02851  199 EYLA----LTGQKLNGVEMIACGLATH 221
PRK12478 PRK12478
crotonase/enoyl-CoA hydratase family protein;
24-110 2.82e-08

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 183548  Cd Length: 298  Bit Score: 52.26  E-value: 2.82e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  24 PVPTIAAMDGFALGGGLELALACDLRIAASSAVMGlieTTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQAREL 103
Cdd:PRK12478  112 SKPVIAQVHGWCVGGASDYALCADIVIASDDAVIG---TPYSRMWGAYLTGMWLYRLSLAKVKWHSLTGRPLTGVQAAEA 188


                  ....*..
gi 1039768216 104 GLVNHAV 110
Cdd:PRK12478  189 ELINEAV 195
PLN03214 PLN03214
probable enoyl-CoA hydratase/isomerase; Provisional
 24-139 5.68e-08

probable enoyl-CoA hydratase/isomerase; Provisional


Pssm-ID: 215635  Cd Length: 278  Bit Score: 51.42  E-value: 5.68e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  24 PVPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGL-LPGAGGTQRLPRCLGVALAKELIFTGRRLNGAQARE 102
Cdd:PLN03214  107 RLATVCAIRGACPAGGCAVSLCCDYRLQTTEGTMGLNEVALGIpVPKFWARLFMGRVIDRKVAESLLLRGRLVRPAEAKQ 186

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1039768216 103 LGLVNHAVAQneegnAAYHRALALAQEILPQAPIAVR 139
Cdd:PLN03214  187 LGLIDEVVPA-----AALMEAAASAMERALKLPSAAR 218
PRK07260 PRK07260
enoyl-CoA hydratase; Provisional
 2-106 8.53e-07

enoyl-CoA hydratase; Provisional


Pssm-ID: 180910 [Multi-domain]  Cd Length: 255  Bit Score: 47.81  E-value: 8.53e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216   2 SDVEVGTFVQRLRGLMSEIaafPVPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLG 81
Cdd:PRK07260   79 SLVKIAELVNEISFAIKQL---PKPVIMCVDGAVAGAAANMAVAADFCIASTKTKFIQAFVGVGLAPDAGGLFLLTRAIG 155

                          90       100
                  ....*....|....*....|....*
gi 1039768216  82 VALAKELIFTGRRLNGAQARELGLV 106
Cdd:PRK07260  156 LNRATHLAMTGEALTAEKALEYGFV 180
PLN02988 PLN02988
3-hydroxyisobutyryl-CoA hydrolase
 20-110 1.38e-06

3-hydroxyisobutyryl-CoA hydrolase


Pssm-ID: 178568 [Multi-domain]  Cd Length: 381  Bit Score: 47.40  E-value: 1.38e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  20 IAAFPVPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVaLAKELIFTGRRLNGAQ 99
Cdd:PLN02988  101 MATYSKAQVSILNGIVMGGGAGVSVHGRFRIATENTVFAMPETALGLFPDVGASYFLSRLPGF-FGEYVGLTGARLDGAE 179

                          90
                  ....*....|.
gi 1039768216 100 ARELGLVNHAV 110
Cdd:PLN02988  180 MLACGLATHFV 190
PLN02157 PLN02157
3-hydroxyisobutyryl-CoA hydrolase-like protein
 9-114 1.54e-06

3-hydroxyisobutyryl-CoA hydrolase-like protein


Pssm-ID: 177817 [Multi-domain]  Cd Length: 401  Bit Score: 47.37  E-value: 1.54e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216   9 FVQRLRGLMSEIAAFPVPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGvALAKEL 88
Cdd:PLN02157  118 FFSSLYSFIYLLGTYLKPHVAILNGVTMGGGTGVSIPGTFRVATDRTIFATPETIIGFHPDAGASFNLSHLPG-RLGEYL 196

                          90       100
                  ....*....|....*....|....*.
gi 1039768216  89 IFTGRRLNGAQARELGLVNHAVAQNE 114
Cdd:PLN02157  197 GLTGLKLSGAEMLACGLATHYIRSEE 222
PLN02267 PLN02267
enoyl-CoA hydratase/isomerase family protein
 6-131 4.28e-05

enoyl-CoA hydratase/isomerase family protein


Pssm-ID: 215151  Cd Length: 239  Bit Score: 42.78  E-value: 4.28e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216   6 VGTFVQRLRGLMSEIAAFPVPTIAAMDGFALGGGLELALACDLRIA-ASSAVMGLIETTRGL-LP-----------GAGG 72
Cdd:PLN02267   76 LHLMVAKLRPLVADLISLPMPTIAAVTGHASAAGFILALSHDYVLMrKDRGVLYMSEVDIGLpLPdyfmallrakiGSPA 155

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1039768216  73 TQRlprclgvalakELIFTGRRLNGAQARELGLVnHAVAQNEEGNAAyhRALALAQEIL 131
Cdd:PLN02267  156 ARR-----------DVLLRAAKLTAEEAVEMGIV-DSAHDSAEETVE--AAVRLGEELA 200
PLN02874 PLN02874
3-hydroxyisobutyryl-CoA hydrolase-like protein
 10-110 9.48e-05

3-hydroxyisobutyryl-CoA hydrolase-like protein


Pssm-ID: 178462 [Multi-domain]  Cd Length: 379  Bit Score: 42.09  E-value: 9.48e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  10 VQRLRGLMSEIAAFPVPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGvALAKELI 89
Cdd:PLN02874   91 VYRMYWLCYHIHTYKKTQVALVHGLVMGGGAGLMVPMKFRVVTEKTVFATPEASVGFHTDCGFSYILSRLPG-HLGEYLA 169

                          90       100
                  ....*....|....*....|.
gi 1039768216  90 FTGRRLNGAQARELGLVNHAV 110
Cdd:PLN02874  170 LTGARLNGKEMVACGLATHFV 190
PRK07112 PRK07112
enoyl-CoA hydratase/isomerase;
13-114 1.59e-04

enoyl-CoA hydratase/isomerase;


Pssm-ID: 235938  Cd Length: 255  Bit Score: 41.21  E-value: 1.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768216  13 LRGLMSEIAAFPVPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPgAGGTQRLPRCLGVALAKELIFTG 92
Cdd:PRK07112   85 LYDLWHRLATGPYVTIAHVRGKVNAGGIGFVAASDIVIADETAPFSLSELLFGLIP-ACVLPFLIRRIGTQKAHYMTLMT 163

                          90       100
                  ....*....|....*....|..
gi 1039768216  93 RRLNGAQARELGLVNHAVAQNE 114
Cdd:PRK07112  164 QPVTAQQAFSWGLVDAYGANSD 185
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH