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Conserved domains on  [gi|1048478233|ref|XP_017517828|]
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Protein Classification

7tmA_prokineticin-R domain-containing protein (domain architecture ID 11606947)

7tmA_prokineticin-R domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
82-372 0e+00

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


:

Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 525.69  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233  82 IVIGVALAGIMLVCGIGNFVFIAALARYKKLRNLTNLLIANLAISDFLVAIICCPFEMDYYVVRQLSWEHGHVLCASVNY 161
Cdd:cd15204     1 IVLGVVYVLIMLVCGVGNLLLIAVLARYKKLRTLTNLLIANLALSDFLVAVFCLPFEMDYYVVRQRSWTHGDVLCAVVNY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 162 LRTVSLYVSTNALLAIALDRYLAIVHPLKPRMNYQTASFLIALVWMVSILIAIPSAYFTTETVLFivkSQEKIFCGQIWP 241
Cdd:cd15204    81 LRTVSLYVSTNALLVIAIDRYLVIVHPLKPRMKRRTACVVIALVWVVSLLLAIPSAVYSKTTPYA---NQGKIFCGQIWP 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 242 VDQQLYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPGFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYG 321
Cdd:cd15204   158 VDQQAYYKAYYLFLFVLEFVLPVLIMTLCYLRIVRKVWFRRVPGQQTEQIRRRLRRRRRKVRLLVVILTAFVLCWAPYYG 237
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1048478233 322 FTIVRDFFPTVFIKEKHYLTAFYVVECIAMSNSMINTVCFVTVKNNTMKYF 372
Cdd:cd15204   238 YAIVRDFFPTLLSKEKLNTTIFYIVEALAMSNSMINTVVYVAFNNNIRKYL 288
 
Name Accession Description Interval E-value
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
82-372 0e+00

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 525.69  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233  82 IVIGVALAGIMLVCGIGNFVFIAALARYKKLRNLTNLLIANLAISDFLVAIICCPFEMDYYVVRQLSWEHGHVLCASVNY 161
Cdd:cd15204     1 IVLGVVYVLIMLVCGVGNLLLIAVLARYKKLRTLTNLLIANLALSDFLVAVFCLPFEMDYYVVRQRSWTHGDVLCAVVNY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 162 LRTVSLYVSTNALLAIALDRYLAIVHPLKPRMNYQTASFLIALVWMVSILIAIPSAYFTTETVLFivkSQEKIFCGQIWP 241
Cdd:cd15204    81 LRTVSLYVSTNALLVIAIDRYLVIVHPLKPRMKRRTACVVIALVWVVSLLLAIPSAVYSKTTPYA---NQGKIFCGQIWP 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 242 VDQQLYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPGFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYG 321
Cdd:cd15204   158 VDQQAYYKAYYLFLFVLEFVLPVLIMTLCYLRIVRKVWFRRVPGQQTEQIRRRLRRRRRKVRLLVVILTAFVLCWAPYYG 237
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1048478233 322 FTIVRDFFPTVFIKEKHYLTAFYVVECIAMSNSMINTVCFVTVKNNTMKYF 372
Cdd:cd15204   238 YAIVRDFFPTLLSKEKLNTTIFYIVEALAMSNSMINTVVYVAFNNNIRKYL 288
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
98-357 1.97e-51

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 333754 [Multi-domain]  Cd Length: 255  Bit Score: 172.88  E-value: 1.97e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233  98 GNFVFIAALARYKKLRNLTNLLIANLAISDFLVAIICCPFEMDYYVVRQlsWEHGHVLCASVNYLRTVSLYVSTNALLAI 177
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFLLLTLPFWLVYYLHGT--WPFGSALCKLVTFLDVVNGYASILLLTAI 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 178 ALDRYLAIVHPLKPRMNYQTASFLIALVWMVSILIAIPSAYFTTetvLFIVKSQEKIFCGQIWPVDqqLYYKSYFLFIFG 257
Cdd:pfam00001  79 SIDRYLAIVHPLRYRRIMRRAKAIILLIWVLALLLSLPPLLGWN---TLDIPSNGVTSCLITFPES--LWPVSYLLFSTV 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 258 IEFVGPVVTMTLCYARISRELWfkavpgFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYGFTIVRDFFPTVFIK-- 335
Cdd:pfam00001 154 LGFLLPLLVILVCYTRIIRTLR------KQQSSSIRSVRSERKALKTLLVVVVVFILCWLPYHILLLLDSLCDLGIIIsc 227
                         250       260
                  ....*....|....*....|....
gi 1048478233 336 --EKHYLTAFYVVECIAMSNSMIN 357
Cdd:pfam00001 228 evVTPPRTLLQLTVWLAYSNSCLN 251
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
97-378 2.40e-18

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 85.22  E-value: 2.40e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233  97 IGNFVFIAALARYKkLRNLTNLLIANLAISDfLVAIICCPFEMDYYVVRQLSWehGHVLCASVNYLRTVSLYVSTNALLA 176
Cdd:PHA03087   56 VGNIIVIYVLTKTK-IKTPMDIYLLNLAVSD-LLFVMTLPFQIYYYILFQWSF--GEFACKIVSGLYYIGFYNSMNFITV 131
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 177 IALDRYLAIVHPLK--PRMNYQTASFLIALVWMVSILIAIPSAYFTTetvlfiVKSQEKIFCGQIWPVDQQLYYKSYFLF 254
Cdd:PHA03087  132 MSVDRYIAIVHPVKsnKINTVKYGYIVSLVIWIISIIETTPILFVYT------TKKDHETLICCMFYNNKTMNWKLFINF 205
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 255 ---IFGieFVGPVVTMTLCYARISRELwfkavpgfQTEQIRKRlrcRRKTVLVLMCILTAYVLCWAPFYGFTIVRDFFPT 331
Cdd:PHA03087  206 einIIG--MLIPLTILLYCYSKILITL--------KGINKSKK---NKKAIKLVLIIVILFVIFWLPFNVSVFVYSLHIL 272
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1048478233 332 VFIKE----KHYLTAFYVVECIAMSNSMINTVCFVTVKNNTMKYFKKMILL 378
Cdd:PHA03087  273 HFKSGckavKYIQYALHVTEIISLSHCCINPLIYAFVSEFFNKHKKKSLKL 323
 
Name Accession Description Interval E-value
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
82-372 0e+00

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 525.69  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233  82 IVIGVALAGIMLVCGIGNFVFIAALARYKKLRNLTNLLIANLAISDFLVAIICCPFEMDYYVVRQLSWEHGHVLCASVNY 161
Cdd:cd15204     1 IVLGVVYVLIMLVCGVGNLLLIAVLARYKKLRTLTNLLIANLALSDFLVAVFCLPFEMDYYVVRQRSWTHGDVLCAVVNY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 162 LRTVSLYVSTNALLAIALDRYLAIVHPLKPRMNYQTASFLIALVWMVSILIAIPSAYFTTETVLFivkSQEKIFCGQIWP 241
Cdd:cd15204    81 LRTVSLYVSTNALLVIAIDRYLVIVHPLKPRMKRRTACVVIALVWVVSLLLAIPSAVYSKTTPYA---NQGKIFCGQIWP 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 242 VDQQLYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPGFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYG 321
Cdd:cd15204   158 VDQQAYYKAYYLFLFVLEFVLPVLIMTLCYLRIVRKVWFRRVPGQQTEQIRRRLRRRRRKVRLLVVILTAFVLCWAPYYG 237
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1048478233 322 FTIVRDFFPTVFIKEKHYLTAFYVVECIAMSNSMINTVCFVTVKNNTMKYF 372
Cdd:cd15204   238 YAIVRDFFPTLLSKEKLNTTIFYIVEALAMSNSMINTVVYVAFNNNIRKYL 288
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
82-372 9.08e-127

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 367.53  E-value: 9.08e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233  82 IVIGVALAGIMLVCGIGNFVFIAALARYKKLRNLTNLLIANLAISDFLVAIICCPFEMDYYVVRqlSWEHGHVLCASVNY 161
Cdd:cd14992     1 IILGVALVVIILVSVVGNFIVIAALARHKNLRGATNYFIASLAISDLLMALFCTPFNFTYVVSL--SWEYGHFLCKIVNY 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 162 LRTVSLYVSTNALLAIALDRYLAIVHPLKPR--MNYQTASFLIALVWMVSILIAIPSAYFTTETVLFIVKSQEKIFCGQI 239
Cdd:cd14992    79 LRTVSVYASSLTLTAIAFDRYFAIIHPLKPRhrQSYTTTVIIIITIWVVSLLLAIPQLYYATTEVLFSVKNQEKIFCCQI 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 240 WPVDQQLYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPGFQ-TEQIRKRLRCRRKTVLVLMCILTAYVLCWAP 318
Cdd:cd14992   159 PPVDNKTYEKVYFLLIFVVIFVLPLIVMTLAYARISRELWFRKVPGFSiKEVERKRLKCKRRVIKMLVCVVVLFVICWLP 238
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1048478233 319 FYGFTIVRDFFPTvFIKEKHYLTAFYVVECIAMSNSMINTVCFVTVKNNTMKYF 372
Cdd:cd14992   239 FHLFFLLRDFFPL-IMKEKHTLQVYYFLHWIAMSNSMYNPIIYVTLNNNFRKNF 291
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
90-357 4.58e-63

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 204.38  E-value: 4.58e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233  90 GIMLVCGI-GNFVFIAALARYKKLRNLTNLLIANLAISDFLVAIICCPFEMDYYVVRQlsWEHGHVLCASVNYLRTVSLY 168
Cdd:cd15203     8 GLIIVLGVvGNLLVIYVVLRNKSMQTVTNIFILNLAVSDLLLCLVSLPFTLIYTLTKN--WPFGSILCKLVPSLQGVSIF 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 169 VSTNALLAIALDRYLAIVHPLKPRMNYQTASFLIALVWMVSILIAIPSAYFTT-ETVLFIVKSQEKIFCGQIWPVDQqlY 247
Cdd:cd15203    86 VSTLTLTAIAIDRYQLIVYPTRPRMSKRHALLIIALIWILSLLLSLPLAIFQElSDVPIEILPYCGYFCTESWPSSS--S 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 248 YKSYFLFIFGIEFVGPVVTMTLCYARISREL---WFK--AVPGFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYGF 322
Cdd:cd15203   164 RLIYTISVLVLQFVIPLLIISFCYFRISLKLrkrVKKkrGKRTLSSRRRRSELRRKRRTNRLLIAMVVVFAVCWLPLNLF 243
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1048478233 323 TIVRDFFPTVFIKEKHYLTAFYVVECIAMSNSMIN 357
Cdd:cd15203   244 NLLRDFEPLPQIDGRHFYLIFLICHLIAMSSACVN 278
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
82-361 2.50e-61

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 200.13  E-value: 2.50e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233  82 IVIGVALAGIMLVCGIGNFVFIAALARYKKLRNLTNLLIANLAISDFLVAIICCPFEMDYYVVRqlSWEHGHVLCASVNY 161
Cdd:cd14993     1 IVLIVLYVVVFLLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMPLTLLENVYR--PWVFGEVLCKAVPY 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 162 LRTVSLYVSTNALLAIALDRYLAIVHPLKPR--MNYQTASFLIALVWMVSILIAIPSAYF--TTETVLFIVKSQEKIFCG 237
Cdd:cd14993    79 LQGVSVSASVLTLVAISIDRYLAICYPLKARrvSTKRRARIIIVAIWVIAIIIMLPLLVVyeLEEIISSEPGTITIYICT 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 238 QIWPvdQQLYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPGFQT----EQIRKRLRCRRKTVLVLMCILTAYV 313
Cdd:cd14993   159 EDWP--SPELRKAYNVALFVVLYVLPLLIISVAYSLIGRRLWRRKPPGDRGsansTSSRRILRSKKKVARMLIVVVVLFA 236
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1048478233 314 LCWAPFYGFTIVRDFFPTVFIKEKH-YLTAFYVVECIAMSNSMINTVCF 361
Cdd:cd14993   237 LSWLPYYVLSILLDFGPLSSEESDEnFLLILPFAQLLGYSNSAINPIIY 285
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
82-357 9.33e-57

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 187.95  E-value: 9.33e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233  82 IVIGVALAGIMLVCGIGNFVFIAALARYKKLRNLTNLLIANLAISDFLVAIICCPFEMdYYVVRQLSWEHGHVLCASVNY 161
Cdd:cd15392     1 VIIILMYSTIFVLAVGGNGLVCYIVVSYPRMRTVTNYFIVNLALSDILMAVFCVPFSF-IALLILQYWPFGEFMCPVVNY 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 162 LRTVSLYVSTNALLAIALDRYLAIVHPLKPRMNYQTASFLIALVWMVSILIAIPSAyFTTETVLFIVKSQEKIFCGQIWP 241
Cdd:cd15392    80 LQAVSVFVSAFTLVAISIDRYVAIMWPLRPRMTKRQALLLIAVIWIFALATALPIA-ITSRLFEDSNASCGQYICTESWP 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 242 VDQQLYYKSYFLFIfgIEFVGPVVTMTLCYARISRELWFKAVPGFQTE-QIRKRLRCRRKTVLVLMCILTAYVLCWAPFY 320
Cdd:cd15392   159 SDTNRYIYSLVLMI--LQYFVPLAVLVFTYTRIGIVVWAKRTPGEAENnRDQRMAESKRKLVKMMITVVAIFALCWLPLN 236
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1048478233 321 GFTIVRDFFPTVFiKEKHYLTAFYVVECIAMSNSMIN 357
Cdd:cd15392   237 ILNLVGDHDESIY-SWPYIPYLWLAAHWLAMSHCCYN 272
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
86-357 3.10e-54

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 341313 [Multi-domain]  Cd Length: 275  Bit Score: 180.94  E-value: 3.10e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233  86 VALAGIMLVCGIGNFVFIAALARYKKLRNLTNLLIANLAISDFLVAIICCPFEMDYYVVRqlSWEHGHVLCASVNYLRTV 165
Cdd:cd00637     3 VLYILIFVVGVVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLG--GWWFGDALCKLLGFLQTV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 166 SLYVSTNALLAIALDRYLAIVHPLKP--RMNYQTASFLIALVWMVSILIAIPSAYFTTETVLFIVksqekifCGQIWPVD 243
Cdd:cd00637    81 SLTASILTLTAISVDRYLAIVHPLRYrrRFTRRRAKLVIALIWLLSLLLALPPLLGWKVYDYGGY-------CCCCLCWP 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 244 QQLYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPGF---QTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFY 320
Cdd:cd00637   154 DSTLRKAYTIFLFVLLFLLPLLVIIVCYVRIFRKLRRHRRRIRrssSNSSRRRRRRRERKVTKMLLIVVVVFLLCWLPYF 233
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1048478233 321 GFTIVRDFFPTVFikeKHYLTAFYVVECIAMSNSMIN 357
Cdd:cd00637   234 ILLLLDVFGPDPS---PLPRILYFLALLLAYLNSAIN 267
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
98-357 1.97e-51

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 333754 [Multi-domain]  Cd Length: 255  Bit Score: 172.88  E-value: 1.97e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233  98 GNFVFIAALARYKKLRNLTNLLIANLAISDFLVAIICCPFEMDYYVVRQlsWEHGHVLCASVNYLRTVSLYVSTNALLAI 177
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFLLLTLPFWLVYYLHGT--WPFGSALCKLVTFLDVVNGYASILLLTAI 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 178 ALDRYLAIVHPLKPRMNYQTASFLIALVWMVSILIAIPSAYFTTetvLFIVKSQEKIFCGQIWPVDqqLYYKSYFLFIFG 257
Cdd:pfam00001  79 SIDRYLAIVHPLRYRRIMRRAKAIILLIWVLALLLSLPPLLGWN---TLDIPSNGVTSCLITFPES--LWPVSYLLFSTV 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 258 IEFVGPVVTMTLCYARISRELWfkavpgFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYGFTIVRDFFPTVFIK-- 335
Cdd:pfam00001 154 LGFLLPLLVILVCYTRIIRTLR------KQQSSSIRSVRSERKALKTLLVVVVVFILCWLPYHILLLLDSLCDLGIIIsc 227
                         250       260
                  ....*....|....*....|....
gi 1048478233 336 --EKHYLTAFYVVECIAMSNSMIN 357
Cdd:pfam00001 228 evVTPPRTLLQLTVWLAYSNSCLN 251
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
82-357 2.34e-50

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 171.27  E-value: 2.34e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233  82 IVIGVALAGIMLVCGIGNFVFIAALARYKKLRNLTNLLIANLAISDFLVAIICCPFEMDYYVVrqLSWEHGHVLCASVNY 161
Cdd:cd15207     1 VLFIVSYSLIFLLCVVGNVLVCLVVAKNPRMRTVTNYFILNLAVSDLLVGVFCMPFTLVDNIL--TGWPFGDVMCKLSPL 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 162 LRTVSLYVSTNALLAIALDRYLAIVHPLKPRMNYQTASFLIALVWMVSILIAIPSAYFTTETVLFIVKSQEKIFCGQIWP 241
Cdd:cd15207    79 VQGVSVAASVFTLVAIAVDRYRAVVHPTEPKLTNRQAFVIIVAIWVLALAIMIPQALVLEVKEYQFFRGQTVHICVEFWP 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 242 VDqqLYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPG---FQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAP 318
Cdd:cd15207   159 SD--EYRKAYTTSLFVLCYVAPLLIIAVLYVRIGYRLWFKPVPGggsASREAQAAVSKKKVRVIKMLIVVVVLFALSWLP 236
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1048478233 319 FYGFTIVRDFFP-TVFIKEKHYLTAFYVVECIAMSNSMIN 357
Cdd:cd15207   237 LHTVTMLDDFGNlSPNQREVLYVYIYPIAHWLAYFNSCVN 276
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
85-357 1.21e-48

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 166.70  E-value: 1.21e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233  85 GVALAGIMLVCGIGNFVFIAALARYKKLRNLTNLLIANLAISDFLVAIICCPFeMDYYVVRQlSWEHGHVLCASVNYLRT 164
Cdd:cd15390     4 SIVFVVMVLVAIGGNLIVIWIVLAHKRMRTVTNYFLVNLAVADLLISAFNTVF-NFTYLLYN-DWPFGLFYCKFSNFVAI 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 165 VSLYVSTNALLAIALDRYLAIVHPLKPRMNYQTASFLIALVWMVSILIAIPSAYFTTETVLFIVKSQEKIFCGQIWPVDQ 244
Cdd:cd15390    82 TTVAASVFTLMAISIDRYIAIVHPLRPRLSRRTTKIAIAVIWLASFLLALPQLLYSTTETYYYYTGSERTVCFIAWPDGP 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 245 QLYYKS-YFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPGFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYGFT 323
Cdd:cd15390   162 NSLQDFvYNIVLFVVTYFLPLIIMAVAYTRVGVELWGSKTIGENTPRQLESVRAKRKVVKMMIVVVVIFAICWLPYHLYF 241
                         250       260       270
                  ....*....|....*....|....*....|....
gi 1048478233 324 IVRDFFPTVFIKeKHYLTAFYVVECIAMSNSMIN 357
Cdd:cd15390   242 ILTYLYPDINSW-KYIQQIYLAIYWLAMSNSMYN 274
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
82-357 7.48e-47

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 161.90  E-value: 7.48e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233  82 IVIGVALAGIMLVCGIGNFVFIAALARYKKLRNLTNLLIANLAISDFLVAIICCPFEMDYYVVRQlsWEHGHVLCASVNY 161
Cdd:cd15202     1 VLLIVAYSFIIVFSLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMITLFNTPFTFVRAVNNT--WIFGLFMCHFSNF 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 162 LRTVSLYVSTNALLAIALDRYLAIVHPLKPRMNYQTASFLIALVWMVSILIAIPSAYFTTETVLFIVKSQEKIFCGQIWP 241
Cdd:cd15202    79 AQYCSVHVSAYTLTAIAVDRYQAIMHPLKPRISKTKAKFIIAVIWTLALAFALPHAICSKLETFKYSEDIVRSLCLEDWP 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 242 VDQQLYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPG-FQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFY 320
Cdd:cd15202   159 ERADLFWKYYDLALFILQYFLPLLVISFAYARVGIKLWASNMPGdATTERYFALRRKKKKVIKMLMVVVVLFALCWLPFN 238
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1048478233 321 GFTIVRDFFPTVFIKEKHYLtaFYVVECIAMSNSMIN 357
Cdd:cd15202   239 IYVLLLSSKPDYLIKTINAV--YFAFHWLAMSSTCYN 273
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
82-357 2.31e-45

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 157.88  E-value: 2.31e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233  82 IVIGVALAGIMLVCGIGNFVFIAALARYKKLRNLTNLLIANLAISDFLVAIICCPFEMDYYVVRQlsWEHGHVLCASVNY 161
Cdd:cd15389     1 ALLIVAYSIIIVISLFGNSLVCHVIFKNKRMHTATNLFIVNLAVSDILITLLNTPFTLVRFVNST--WVFGKIMCHLSRF 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 162 LRTVSLYVSTNALLAIALDRYLAIVHPLKPRMNYQTASFLIALVWMVSILIAIPSAYFTTETVLFIVKSQEKIFCGQIWP 241
Cdd:cd15389    79 AQYCSVYVSTLTLTAIALDRHRVILHPLKPRITPCQGVVVIAIIWIMASCLSLPHAIYQKLVEFEYSNERTRSRCLPSFP 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 242 VDQQLYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWF-KAVPGFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFY 320
Cdd:cd15389   159 EPSDLFWKYLDLATFILQYVLPLLIIGVAYTRVAKKLWLrNAIGDVTTEQYVAQRRKKKKTIKMLMLVVLLFAICWLPLN 238
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1048478233 321 GFTIVRDFFPTvfikeKHYLTAFYVVECIAMSNSMIN 357
Cdd:cd15389   239 CYHVLLSSHPI-----RSNSALFFAFHWLAMSSTCYN 270
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
91-357 4.66e-43

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 152.20  E-value: 4.66e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233  91 IMLVCGIGNFVFIAALARYKKLRNLTNLLIANLAISDFLVAIICCPFEMdYYVVRQLSWEHGHVLCASVNYLRTVSLYVS 170
Cdd:cd15394    10 VVLVGVVGNYLLIYVICRTKKMHNVTNFLIGNLAFSDMLMCATCVPLTL-AYAFEPRGWVFGRFMCYFVFLMQPVTVYVS 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 171 TNALLAIALDRYLAIVHPLKPRMNYQTASFLIALVWMVSILIAIPSAYFTTETVLfivKSQEKIFCGQIW--PVDQQLYY 248
Cdd:cd15394    89 VFTLTAIAVDRYYVTVYPLRRRISRRTCAYIVAAIWLLSCGLALPAAAHTYYVEF---KGLDFSICEEFWfgQEKQRLAY 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 249 KSYFLFifgIEFVGPVVTMTLCYARISRELWFKAVPGFQTE-QIRKRLRCRRKTVLVLMCILTAYVLCWAPFYGFTIVRD 327
Cdd:cd15394   166 ACSTLL---ITYVLPLLAISLSYLRISVKLRNRVVPGSMTQsQAEWDRARRRKTFRLLVVVVVAFAICWLPLHIFNVIRD 242
                         250       260       270
                  ....*....|....*....|....*....|
gi 1048478233 328 FFPTvFIKEKHYLTAFYVVECIAMSNSMIN 357
Cdd:cd15394   243 IDID-LIDKQYFNLIQLLCHWLAMSSACYN 271
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
89-357 3.37e-40

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaeastagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 144.47  E-value: 3.37e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233  89 AGIMLVCGIGNFVFIAALARYKKLRNLTNLLIANLAISDFLVAIICCPFEMDYYVVRqlSWEHGHVLCASVNYLRTVSLY 168
Cdd:cd15393     8 GIISLVAVVGNFLVIWVVAKNRRMRTVTNIFIANLAVADIIIGLFSIPFQFQAALLQ--RWVLPRFMCPFCPFVQVLSVN 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 169 VSTNALLAIALDRYLAIVHPLKPRMNYQTASFLIALVWMVSILIAIPSA-YFTTETVLFIVKSQEKIFCGQIWPVDQQLy 247
Cdd:cd15393    86 VSVFTLTVIAVDRYRAVIHPLKARCSKKSAKIIILIIWILALLVALPVAlALRVEELTDKTNNGVKPFCLPVGPSDDWW- 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 248 yKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPG-FQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYGFTIVR 326
Cdd:cd15393   165 -KIYNLYLVCVQYFVPLVIICYAYTRIAVKIWGTKAPGnAQDVRDDEILKNKKKVIKMLIIVVALFALCWLPLQTYNLLN 243
                         250       260       270
                  ....*....|....*....|....*....|..
gi 1048478233 327 DFFPTvfIKEKHYLT-AFYVVECIAMSNSMIN 357
Cdd:cd15393   244 EIKPE--INKYKYINiIWFCSHWLAMSNSCYN 273
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
83-357 4.00e-40

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 143.47  E-value: 4.00e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233  83 VIGVALAGIMLVCGIGNFVFIAALARYKKLRNLTNLLIANLAISDFLVAIICCPFEMDYYVVRqlSWEHGHVLCASVNYL 162
Cdd:cd14967     1 LLAVFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLG--YWPFGPVLCRFWIAL 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 163 RTVSLYVSTNALLAIALDRYLAIVHPL--KPRMNYQTASFLIALVWMVSILIAIPSayftteTVLFIVKSQEKIFCGQIW 240
Cdd:cd14967    79 DVLCCTASILNLCAISLDRYLAITRPLryRQLMTKKRALIMIAAVWVYSLLISLPP------LVGWRDETQPSVVDCECE 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 241 PVdqqlYYKSYFLFIFGIEFVGPVVTMTLCYARISRELwfkavpgfQTEqirkrlrcrRKTVLVLMCILTAYVLCWAPFY 320
Cdd:cd14967   153 FT----PNKIYVLVSSVISFFIPLLIMIVLYARIFRVA--------RRE---------LKAAKTLAIIVGAFLLCWLPFF 211
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1048478233 321 GFTIVRDFFPTVFIKEkhylTAFYVVECIAMSNSMIN 357
Cdd:cd14967   212 IIYLVSAFCPPDCVPP----ILYAVFFWLGYLNSALN 244
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
82-372 1.22e-38

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 140.50  E-value: 1.22e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233  82 IVIGVALAGIMLVCGIGNFVFIAALARYKKLRNLTNLLIANLAISDFLVAIICCPFEMDYYVVrqLSWEHGHVLCASVNY 161
Cdd:cd15095     1 WLVPLIFAIIFLVGLAGNSLVIYVVSRHREMRTVTNYYIVNLAVTDLAFLVCCVPFTAALYAT--PSWVFGDFMCKFVNY 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 162 LRTVSLYVSTNALLAIALDRYLAIVHPLKpRMNYQT---ASFLIALVWMVSILIAIPSAYFTTETVLFIVKSQekIFCGQ 238
Cdd:cd15095    79 MMQVTVQATCLTLTALSVDRYYAIVHPIR-SLRFRTprvAVVVSACIWIVSFLLSIPVAIYYRLEEGYWYGPQ--TYCRE 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 239 IWPvdQQLYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPGFQTEQI--RKRLRCRRKTVLVLMCILTAYVLCW 316
Cdd:cd15095   156 VWP--SKAFQKAYMIYTVLLTYVIPLAIIAVCYGLILRRLWRRSVDGNNQSEQlsERALRQKRKVTRMVIVVVVLFAICW 233
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 317 APFYGFTIVRDFFPtvfikEKHYLTAFYVVE----CIAMSNSMINTVCFVTVKNNTMKYF 372
Cdd:cd15095   234 LPNHVLNLWQRFDP-----NFPETYATYALKiaalCLSYANSAVNPFVYAFMGENFRKYF 288
7tmA_NPY2R cd15399
neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G ...
82-372 1.39e-38

neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320521 [Multi-domain]  Cd Length: 285  Bit Score: 139.95  E-value: 1.39e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233  82 IVIGVALAGIMLVCGIGNFVFIAALARYKKLRNLTNLLIANLAISDFLVAIICCPFEMDYYVVRQlsWEHGHVLCASVNY 161
Cdd:cd15399     1 IVLILAYCSIILLGVVGNSLVIYVVIKFKNMRTVTNFFIANLAVADLMVNTLCLPFTLVYTLLDE--WKFGAVLCHLVPY 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 162 LRTVSLYVSTNALLAIALDRYLAIVHPLKPRMNYQTASFLIALVWMVSILIAIPSAYFTTETVLFIVKSQEKIFCGQIWP 241
Cdd:cd15399    79 AQALAVHVSTVTLTVIALDRHRCIVYHLESKISKKISFLIIGLTWAASALLASPLAIFREYSVIEISPDFKIQACSEKWP 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 242 VDQQLYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPGFQTEQIRKRlrcRRKTVLVLMCILTAYVLCWAPFYG 321
Cdd:cd15399   159 NGTLNDGTIYSVSMLLIQYVLPLAIISYAYIRIWTKLKNHVSPGGGNDHYHQR---RRKTTKMLVCVVVVFAVSWLPFHA 235
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1048478233 322 FTIVRDFFPTVFiKEKHYLTAFYVVECIAMSNSMINTVCFVTVKNNTMKYF 372
Cdd:cd15399   236 FQLASDIDSKVL-DLKEYKLIYTIFHVIAMCSTFANPLLYGWMNNNYRTAF 285
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
82-359 2.75e-38

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 139.83  E-value: 2.75e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233  82 IVIGVALAGIMLVCgignfvfiAALARYKKLRNLTNLLIANLAISDFLVAIICCPFEMDYYVVRqlSWEHGHVLCASVNY 161
Cdd:cd15208     9 LVFIVGLVGNVLVC--------FAVWRNHHMRTVTNYFIVNLSLADFLVIIICLPATLLVDVTE--TWFFGQVLCKIIPY 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 162 LRTVSLYVSTNALLAIALDRYLAIVHPLKPRMNYQTASFLIALVWMVSILIAIPSAYFtTETVLFIVKSQEKI---FCGQ 238
Cdd:cd15208    79 LQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARVSILIIWIVSLLIMIPQAIV-MECSRVVPLANKTIlltVCDE 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 239 IWPVDQqlYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPGFQTEQIR--------------KRLRCRRKTVLV 304
Cdd:cd15208   158 RWSDSI--YQKVYHICFFLVTYLLPLCLMILAYFQIFRKLWCRQIPGTSSVVQRkwnkprksavaaeeKQLRSRRKTAKM 235
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1048478233 305 LMCILTAYVLCWAPFYGFTIVRDFFpTVFIKEKHYLTAFYVV-ECIAMSNSMINTV 359
Cdd:cd15208   236 LIVVVIMFAICYLPVHLLNILRYVF-GLFTVDRETIYAWFLFsHWLVYANSAINPI 290
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
91-361 5.25e-37

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 135.48  E-value: 5.25e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233  91 IMLVCGIGNFVFIAALARYKKLRNLTNLLIANLAISDFLVAIICCPFEMDYYVVrqLSWEHGHVLCASVNYLRTVSLYVS 170
Cdd:cd15001     9 TFVLGLIGNSLVIFVVARFRRMRSVTNVFLASLATADLLLLVFCVPLKTAEYFS--PTWSLGAFLCKAVAYLQLLSFICS 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 171 TNALLAIALDRYLAIVHPLKPRM--NYQTASFLIALVWMVSILIAIPSAYFTTETVLFIVKSQEKIFCGQIWPvdQQLYY 248
Cdd:cd15001    87 VLTLTAISIERYYVILHPMKAKSfcTIGRARKVALLIWILSAILASPVLFGQGLVRYESENGVTVYHCQKAWP--STLYS 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 249 KSYFLFIFGIEFVGPVVTMTLCYARISrelwfkavpgfqteqirkrlrcRRKTVLVLMCILTAYVLCWAPF--YGFTIVR 326
Cdd:cd15001   165 RLYVVYLAIVIFFIPLIVMTFAYARDT----------------------RKQVIKMLISVVVLFAVCWGPLliDNLLVSF 222
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1048478233 327 DFFPTVFIKEKHYLTAFYvvECIAMSNSMINTVCF 361
Cdd:cd15001   223 DVISTLHTQALKYMRIAF--HLLSYANSCINPIIY 255
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
98-361 1.02e-36

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 135.34  E-value: 1.02e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233  98 GNFVFIAALARYKKLRNLTNLLIANLAISDFLVAIICCPFEMDYYVVRQlsWEHGHVLCASVNYLRTVSLYVSTNALLAI 177
Cdd:cd15391    17 GNYSVIVVFYDGRRSRTDLNYYLINLAVSDLIMALFCMPFTFTQIMLGH--WVFPAPMCPIVLYVQLVSVTASVLTNTAI 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 178 ALDRYLAIVHPLKPRMNYQTASFLIALVWMVSILIAiPSAYFTTETVLFIVKSQEKIFCGQIWPvdQQLYYKS-YFLFIF 256
Cdd:cd15391    95 GIDRFFAVIFPLRSRHTKSRTKCIIASIWAISFSLS-SVQLFAGRTQRYGQYSEGRVLCGESWP--GPDTSRSaYTVFVM 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 257 GIEFVGPVVTMTLCYARISRELWFKAVPGFQTEQI-RKRLRCRRKTVLVLMCILTAYVLCWAPFYGFTIVRDfFPTVFIK 335
Cdd:cd15391   172 LLTYIIPLLILTSTYGYVGFRLWNRTAPGNADKGRdDMQIKSKRKVIKMLVFVVLMFGICWLPLHLFNLVQD-FSTVFRN 250
                         250       260
                  ....*....|....*....|....*...
gi 1048478233 336 EKHYLT--AFYVVECIAMSNSMINTVCF 361
Cdd:cd15391   251 MPQHTTrlIYGACHWIAMSNSFVNPIIY 278
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
87-361 1.07e-36

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 135.20  E-value: 1.07e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233  87 ALAGIMLVCGIGNFVFIAALARYKKLRNLTNLLIANLAISDFLVAIICCPFEMDYYVVRQlsWEHGHVLCASVNYLRTVS 166
Cdd:cd14986     6 VLGVLFVFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADLVVAFFTVLTQIIWEATGE--WVAGDVLCRIVKYLQVVG 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 167 LYVSTNALLAIALDRYLAIVHPLKPRMNYQTASFLIALVWMVSILIAIPSAYfttetvLFIVKSQEKIF--CGQIWPVDQ 244
Cdd:cd14986    84 LFASTYILVSMSLDRYQAIVKPMSSLKPRKRARLMIVVAWVLSFLFSIPQLV------IFVERELGDGVhqCWSSFYTPW 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 245 QLyyKSYFLFIFGIEFVGPVVTMTLCYARISRELW-----FKAVPGFQTEQIRKRLRCRR-----------KTVLVLMCI 308
Cdd:cd14986   158 QR--KVYITWLATYVFVIPLIILSYCYGRILRTIWirsrqKTDRPIAPTAMSCRSVSCVSsrvslisrakiKTIKMTLVI 235
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1048478233 309 LTAYVLCWAPFYGFTIVRDFFPTVFIKEkhylTAFYVVECIAMSNSMINTVCF 361
Cdd:cd14986   236 ILAFILCWTPYFIVQLLDVYAGMQQLEN----DAYVVSETLASLNSALNPLIY 284
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
83-372 1.14e-36

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 134.73  E-value: 1.14e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233  83 VIGVALAGIMLVCG-IGNFVFIAALARYKKLRNLTNLLIANLAISDFLVAIICcPFEMDYYVVRqlSWEHGHVLCASVNY 161
Cdd:cd14970     1 IVIPAVYSVVCVVGlTGNSLVIYVILRYSKMKTVTNIYILNLAVADELFLLGL-PFLATSYLLG--YWPFGEVMCKIVLS 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 162 LRTVSLYVSTNALLAIALDRYLAIVHPLK--PRMNYQTASFLIALVWMVSILIAIPSAYFTTetvlFIVKSQEKIFCGQI 239
Cdd:cd14970    78 VDAYNMFTSIFCLTVMSVDRYLAVVHPVKslRFRTPRKAKLVSLCVWALSLVLGLPVIIFAR----TLQEEGGTISCNLQ 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 240 WPVDQQLYYKSYFLFIFGIEFVGPVVTMTLCYARISRELwfKAV-PGFQTEQIRKRLRCRRKTVLVLMcILTAYVLCWAP 318
Cdd:cd14970   154 WPDPPDYWGRVFTIYTFVLGFAVPLLVITVCYSLIIRRL--RSSrNLSTSGAREKRRARRKVTRLVLV-VVAVFVVCWLP 230
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1048478233 319 FYGFTIVRdffptVFIKEKHYLTA---FYVVECIAMSNSMINTVCFVTVKNNTMKYF 372
Cdd:cd14970   231 FHVFQIVR-----LLIDPPETLTVvgvFLFCIALSYANSCLNPILYAFLDENFRKSF 282
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
91-372 1.24e-36

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 135.29  E-value: 1.24e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233  91 IMLVCGIGNFVFIAALARYKKLRNLTNLLIANLAISDFLVAIICCPFEMDYYVVRQlsWEHGHVLCASVNYLRTVSLYVS 170
Cdd:cd15205    10 IFVLALFGNSLVIYVVTRKRAMRTATNIFICSLALSDLLITFFCIPFTLLQNISSN--WLGGAFMCKMVPFVQSTAVVTS 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 171 TNALLAIALDRYLAIVHPLKPRMNY--QTASFLIALVWMVSILIAIPSAYF-TTETVLFIVKSQEKIFCGQIWpvDQQLY 247
Cdd:cd15205    88 ILTMTCIAVERHQGIVHPLKMKWQYtnRRAFTMLGLVWIVSVIVGSPMLFVqQLEVKYDFLYEKRHVCCLERW--YSPTQ 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 248 YKSYFLFIFGIEFVGPVVTMTLCYARISRELWFK----------AVPGFQTEQIrkrLRCRRKTVLVLMCILTAYVLCWA 317
Cdd:cd15205   166 QKIYTTFILVILFLLPLTTMLFLYSRIGYELWIKkrvgdasvlqTIHGIEMSKI---SRKKKRAVKMMVTVVLLFAVCWA 242
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1048478233 318 PFYGFTIVRDFfpTVFIKEKHYLTA---FYVVECIAMSNSMINTVCFVTVKNNTMKYF 372
Cdd:cd15205   243 PFHVVHMMIEY--SNLENKYDGVTIkliFAIVQLIGFSNSFNNPIVYAFMNENFKKNF 298
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
83-372 9.42e-36

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 132.59  E-value: 9.42e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233  83 VIGVALAGIMLVCGIGNFVFIAALARYKKLRNLTNLLIANLAISDFLVAIICCPFEMDYYVVRqlSWEHGHVLCASVNYL 162
Cdd:cd14971     2 IVPLFFALIFLLGLVGNSLVILVVARNKPMRSTTNLFILNLAVADLTFLLFCVPFTATIYPLP--GWVFGDFMCKFVHYF 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 163 RTVSLYVSTNALLAIALDRYLAIVHPL--KPRMNYQTASFLIALVWMVSILIAIPSAYFTTetvLFIVKSQEKIFCGQIW 240
Cdd:cd14971    80 QQVSMHASIFTLVAMSLDRFLAVVYPLrsLHIRTPRNALAASGCIWVVSLAVAAPVLALHR---LRNYTPGNRTVCSEAW 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 241 PvdQQLYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPGFQTEQIRkrlRCRRKTVLVLMCILTAYVLCWAPFY 320
Cdd:cd14971   157 P--SRAHRRAFALCTFLFGYLLPLLLICVCYAAMLRHLWRVAVRPVLSEGSR---RAKRKVTRLVLVVVVLFAACWGPIH 231
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1048478233 321 GFTIVRDFFPTVFIKEKHYLTAFyvVECIAMSNSMINTVCFVTVKNNTMKYF 372
Cdd:cd14971   232 AILLLVALGPFPLTYATYALRIW--AHCLAYSNSAVNPVLYAFLSEHFRKAF 281
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
86-361 1.20e-32

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 124.27  E-value: 1.20e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233  86 VALAGIMLVCGIGNFVFIAALARYKKLRNLTNLLIANLAISDFLVAIICCPFEMDYYVVRQlsWEHGHVLCASVNYLRTV 165
Cdd:cd16003     5 LAYGFVVAVAVFGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASMAAFNTLINFIYALHSE--WYFGEAYCRFHNFFPIT 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 166 SLYVSTNALLAIALDRYLAIVHPLKPRMNYQTASFLIALVWMVSILIAIPSAYFTTETVLfivksQEKIFCGQIWPVDQQ 245
Cdd:cd16003    83 SVFASIYSMTAIAVDRYMAIIDPLKPRLSATATKVVIGSIWILAFLLAFPQCLYSKTKVM-----PGRTLCFVAWPGGPD 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 246 LYYKSYFLFIFgIEFVGPVVTMTLCYARISRELWFKAVPGFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYGFTIV 325
Cdd:cd16003   158 QHFTYHIIVIV-LVYCLPLLVMGITYTIVGITLWGGEIPGDTSDKYHEQLRAKRKVVKMMIIVVLTFAICWLPYHIYFIV 236
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1048478233 326 RDFFPTV----FIKEKhYLTAFYvvecIAMSNSMINTVCF 361
Cdd:cd16003   237 TGLYQQLnrwkYIQQV-YLASFW----LAMSSTMYNPIIY 271
7tmA_NPY4R cd15397
neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G ...
86-374 1.92e-32

neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320519  Cd Length: 293  Bit Score: 123.70  E-value: 1.92e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233  86 VALAGIMLVCG-IGNFVFIAALARYKKLRNLTNLLIANLAISDFLVAIICCPFE-----MDYyvvrqlsWEHGHVLCASV 159
Cdd:cd15397     4 VVSYSLVMAVGlLGNICLICVIARQKEKTNVTNILIANLSFSDILVCLVCLPFTvvytlMDY-------WIFGEVLCKMT 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 160 NYLRTVSLYVSTNALLAIALDRYLAIVHPLKPRMNYQTASFLIALVWMVSILIAIPSAYFTTET-------VLFIVKSQE 232
Cdd:cd15397    77 PFIQCMSVTVSILSLVLIALERHQLIINPTGWKPSVSQAYLAVVVIWMLACFISLPFLAFHILTdepyknlSHFFAPLAD 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 233 KIFCGQIWPVDQQLYYKSYFLFIFgiEFVGPVVTMTLCYARISRELWFKAVPGFQTEQIRKRLRCRRKTVLVLMCILTAY 312
Cdd:cd15397   157 KAVCTESWPSEHHKLAYTTWLLLF--QYCLPLLFILVCYLRIYLRLRRRKDMLERRGEYNRRAGHSKRINVMLVSLVAAF 234
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1048478233 313 VLCWAPFYGFTIVRDFFPTVFIKEKHYLTaFYVVECIAMSNSMINTVCFVTVKNNtmkyFKK 374
Cdd:cd15397   235 ALCWLPLNVFNAIADWNHEAIPHCQHNLI-FSLCHLAAMASTCVNPIIYGFLNSN----FKK 291
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
82-372 4.65e-32

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 122.53  E-value: 4.65e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233  82 IVIGVALAGIMLVCGIGNFVFIAALARYKKL--RNLTNLLIANLAISDFLVAIICCPFEMDYYVVRqlSWEHGHVLCASV 159
Cdd:cd15098     1 VIVPVVFGLIFCLGVLGNSLVITVLARVKPGkrRSTTNVFILNLSIADLFFLLFCVPFQATIYSLP--EWVFGAFMCKFV 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 160 NYLRTVSLYVSTNALLAIALDRYLAIVHPLKPR--MNYQTASFLIALVWMVSILIAIPSAYftTETVLFIVKSQEKIFCG 237
Cdd:cd15098    79 HYFFTVSMLVSIFTLVAMSVDRYIAVVHSRTSSslRTRRNALLGVLVIWVLSLAMASPVAV--HQDLVHHWTASNQTFCW 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 238 QIWPVDQQlyYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAvpgfqTEQIRKRLRCRRKTVLVLMCILTAYVLCWA 317
Cdd:cd15098   157 ENWPEKQQ--KPVYVVCTFVFGYLLPLLLITFCYAKVLNHLHKKL-----KNMSKKSERSKKKTAQTVLVVVVVFGISWL 229
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1048478233 318 PFYGFTIVRDF--FPtvfikekhYLTAFYVVE----CIAMSNSMINTVCFVTVKNNTMKYF 372
Cdd:cd15098   230 PHHIIHLWVEFgdFP--------LTQASFVLRitahCLAYANSCVNPIIYAFLSENFRKAY 282
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
83-359 1.32e-31

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 121.61  E-value: 1.32e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233  83 VIGVALAGIMLVCGIGNFVFIAALARYKKLRNLTNLLIANLAISDFLVAIICCPFEMDYYVVRqlSWEHGHVLCASVNYL 162
Cdd:cd15927     2 VVPILFALIFLVGVLGNGTLILIFLRNKSMRNVPNIFILSLALGDLLLLLTCVPFTSTIYTLD--SWPFGEFLCKLSEFL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 163 RTVSLYVSTNALLAIALDRYLAIVHPLkpRMNYQTASFLIAL----VWMVSILIAIPSAYFTTETVLFIVKSQEKIFCGQ 238
Cdd:cd15927    80 KDTSIGVSVFTLTALSADRYFAIVNPM--RKHRSQATRRTLVtaasIWIVSILLAIPEAIFSHVVTFTLTDNQTIQICYP 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 239 IWPVDQQLYYKSYFLFIFGIEFVGPVVTMTLCYARISRELW--FKAVPGFQTEQIRKRLRCRRKTVLVLMCILTAYVLCW 316
Cdd:cd15927   158 YPQELGPNYPKIMVLLRFLVYYLIPLLIIGVFYVLMARHLIrsTRNIGSGQNQAAQRQIEARKKVAKTVLAFVVLFAVCW 237
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1048478233 317 APFYGFTIVRDFFPTVFIKEKHYLTAFYVVE-CIAMSNSMINTV 359
Cdd:cd15927   238 LPRHVFMLWFHFAPNGLVDYNAFWHVLKIVGfCLSFINSCVNPV 281
7tmA_NK1R cd16002
neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
86-361 1.37e-31

neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neurokinin 1 receptor (NK1R), also known as tachykinin receptor 1 (TACR1) or substance P receptor (SPR), is a G-protein coupled receptor found in the mammalian central nervous and peripheral nervous systems. The tachykinins act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. SP is an extremely potent vasodilator through endothelium dependent mechanism and is released from the autonomic sensory nerves. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320668 [Multi-domain]  Cd Length: 284  Bit Score: 121.13  E-value: 1.37e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233  86 VALAGIMLVCGIGNFVFIAALARYKKLRNLTNLLIANLAISDFLVAIICCPFEMDYYVVRQlsWEHGHVLCASVNYLRTV 165
Cdd:cd16002     5 VAYSVIVVVSVVGNIIVMWIILAHKRMRTVTNYFLVNLAFAEASMSAFNTVINFTYAIHNE--WYYGLEYCKFHNFFPIA 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 166 SLYVSTNALLAIALDRYLAIVHPLKPRMNYQTASFLIALVWMVSILIAIPSAYFTTETVLFivksqEKIFCGQIWPVDQQ 245
Cdd:cd16002    83 AVFASIYSMTAIALDRYMAIIHPLQPRLSATATKVVICVIWVLAFLLAFPQGYYSDTEEMP-----GRVVCYVEWPEHEE 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 246 LYY-KSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPGFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYGFTI 324
Cdd:cd16002   158 RKYeTVYHVCVTVLIYFLPLLVIGCAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPYHIYFL 237
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1048478233 325 VRDFFPTVFIKeKHYLTAFYVVECIAMSNSMINTVCF 361
Cdd:cd16002   238 LQYFHPELYEQ-KFIQQVYLAIMWLAMSSTMYNPIIY 273
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
97-365 3.57e-30

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 117.32  E-value: 3.57e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233  97 IGNFVFIAALARYKKLRNLTNLLIANLAISDFLVAIICcPFEMDYYVVrqlSWEHGHVLCASVNYLRTVSLYVSTNALLA 176
Cdd:cd14984    16 VGNSLVLLVLLYYRKLRSMTDVYLLNLALADLLFVLTL-PFWAVYAAD---GWVFGSFLCKLVSALYTINFYSGILFLAC 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 177 IALDRYLAIVHPLkPRMNYQTASFLI---ALVWMVSILIAIPSAYFTTetvlfIVKSQEKIFCGQIWPVDQQLYYKSYFL 253
Cdd:cd14984    92 ISIDRYLAIVHAV-SALRARTLLHGKltcLGVWALALLLSLPEFIFSQ-----VSEENGSSICSYDYPEDTATTWKTLLR 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 254 F---IFGieFVGPVVTMTLCYARISRELwfkavpgfqteqIRKRLRCRRKTVLVLMCILTAYVLCWAPFYGFTIVRDFFP 330
Cdd:cd14984   166 LlqnILG--FLLPLLVMLFCYSRIIRTL------------LRARNHKKHRALRVIFAVVVVFFLCWLPYNIVLLLDTLQL 231
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1048478233 331 TVFIK-----EKHYLTAFYVVECIAMSNSMINTV--CFVTVK 365
Cdd:cd14984   232 LGIISrscelSKSLDYALQVTESLAFSHCCLNPVlyAFVGVK 273
7tmA_SKR_NK2R cd16004
substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
86-361 4.99e-30

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320670 [Multi-domain]  Cd Length: 285  Bit Score: 117.25  E-value: 4.99e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233  86 VALAGIMLVCGIGNFVFIAALARYKKLRNLTNLLIANLAISDFLVAIICCPFEMDYyvVRQLSWEHGHVLCASVNYLRTV 165
Cdd:cd16004     5 IAYSLIVLVAVTGNATVIWIILAHRRMRTVTNYFIVNLALADLSMAAFNTAFNFVY--ASHNDWYFGLEFCRFQNFFPIT 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 166 SLYVSTNALLAIALDRYLAIVHPLKPRMNYQTASFLIALVWMVSILIAIPSAYFTTetvlfIVKSQEKIFCGQIWPVD-- 243
Cdd:cd16004    83 AMFVSIYSMTAIAADRYMAIIHPFKPRLSAGSTKVVIAGIWLVALALAFPQCFYST-----VTMDQGRTKCIVAWPGDsg 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 244 --QQLyykSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPGFQ-TEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFY 320
Cdd:cd16004   158 gkHQL---TYHLAVIVLIYLLPLAVMFVTYSIIGITLWRSAVPGHQaHGAYHRQLQAKKKFVKTMVVVVVTFAICWLPYH 234
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1048478233 321 GFTIVRDFFPTVFiKEKHYLTAFYVVECIAMSNSMINTVCF 361
Cdd:cd16004   235 LYFILGSFNEDIY-CQKYIQQVYLAIFWLAMSSTMYNPIIY 274
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
91-361 7.86e-30

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 115.95  E-value: 7.86e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233  91 IMLVCGIGNFVFIAALARYKKLRNLTNLLIANLAISDFLVAIICCPFEMDYYVVRQLSWehGHVLCASVNYLRTVSLYVS 170
Cdd:cd15206    10 IFLLAVVGNILVIVTLVQNKRMRTVTNVFLLNLAVSDLLLAVFCMPFTLVGQLLRNFIF--GEVMCKLIPYFQAVSVSVS 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 171 TNALLAIALDRYLAIVHPLKPRMnYQTASF---LIALVWMVSILIAIPSAYFtTETVLFIVKSQEKifCGQIWPVDQqlY 247
Cdd:cd15206    88 TFTLVAISLERYFAICHPLKSRV-WQTLSHaykVIAGIWLLSFLIMSPILVF-SNLIPMSRPGGHK--CREVWPNEI--A 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 248 YKSYFLFIFGIEFVGPVVTMTLCYARISRELWfkavpgfqteqirkrlRCRRKTVLVLMCILTAYVLCWAPFYGFTIVRD 327
Cdd:cd15206   162 EQAWYVFLDLMLLVIPGLVMSVAYGLISWTLL----------------EAKKRVIRMLFVIVVEFFICWTPLYVINTWKA 225
                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1048478233 328 FFPTVFIKEKHYlTAFYVVECIAMSNSMIN--TVCF 361
Cdd:cd15206   226 FDPPSAARYVSS-TTISLIQLLAYISSCVNpiTYCF 260
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
82-357 1.95e-29

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 115.47  E-value: 1.95e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233  82 IVIGVALAGIMLVCGIGN-FVFIAALARyKKLRNLTNLLIANLAISDFLVAIICCPFEMDYYVVRQlsWEHGHVLCASVN 160
Cdd:cd15096     1 IVVPVIFGLIFIVGLIGNsLVILVVLSN-QQMRSTTNILILNLAVADLLFVVFCVPFTATDYVLPT--WPFGDVWCKIVQ 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 161 YLRTVSLYVSTNALLAIALDRYLAIVHPLKPRM--NYQTASFLIALVWMVSILIAIPSAyFTTETVLFIVKSQEKIFCGQ 238
Cdd:cd15096    78 YLVYVTAYASVYTLVLMSLDRYLAVVHPITSMSirTERNTLIAIVGIWIVILVANIPVL-FLHGVVSYGFSSEAYSYCTF 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 239 IWPVDQ--QLYYKSYFLFIFGIefvgPVVTMTLCYARISRELWFKAVPGFQ--TEQIRKRLRCRRKTVLVLMciltAYVL 314
Cdd:cd15096   157 LTEVGTaaQTFFTSFFLFSYLI----PLTLICVLYMLMLRRLRRQKSPGGRrsAESQRGKRRVTRLVVVVVV----VFAI 228
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1048478233 315 CWAPFYGFTIVRDFfpTVFIKEKHYLTAFYVVECIAMSNSMIN 357
Cdd:cd15096   229 CWLPIHIILLLKYY--GVLPETVLYVVIQILSNCLAYGNSCVN 269
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
91-330 1.36e-28

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 112.99  E-value: 1.36e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233  91 IMLVCGIGNFVFIAALARYKKLRNLTNLLIANLAISDFLVAIICCPFEMDYYVVRQLSWehGHVLCASVNYLRTVSLYVS 170
Cdd:cd15979    10 IFLLSVFGNMLIIVVLGLNKRLRTVTNSFLLSLALSDLMLAVFCMPFTLIPNLMGTFIF--GEVICKAVAYLMGVSVSVS 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 171 TNALLAIALDRYLAIVHPLKPRMnYQTASF---LIALVWMVSILIAIPSAYFTTeTVLFIVKSQEKIF-CGQIWPVDQql 246
Cdd:cd15979    88 TFSLVAIAIERYSAICNPLQSRV-WQTRSHayrVIAATWLLSGLIMIPYPVYSV-TVPVPVGDRPRGHqCRHAWPSAQ-- 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 247 YYKSYFLFIFGIEFVGPVVTMTLCYARISRELWfkavpgfqteqirKRLRCRRKTVLVLMCILTAYVLCWAPFYGFTIVR 326
Cdd:cd15979   164 VRQAWYVLLLLILFFIPGVVMIVAYGLISRELY-------------RGLLAKKRVIRMLVVIVAMFFLCWLPIFSANTWR 230

                  ....
gi 1048478233 327 DFFP 330
Cdd:cd15979   231 AFDP 234
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
91-366 1.78e-28

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320  Cd Length: 284  Bit Score: 112.86  E-value: 1.78e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233  91 IMLVCGIGNFVFIAALARYKKLRNLTNLLIANLAISDfLVAIICCPFEMDYYVvRQLSWEHGHVLCASVNYLRTVSLYVS 170
Cdd:cd14985    10 IFLVGLLGNLFVVWVFLFPRGPKRVADIFIANLAAAD-LVFVLTLPLWATYTA-NQYDWPFGAFLCKVSSYVISVNMFAS 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 171 TNALLAIALDRYLAIVHPLK--PRMNYQTASFLIALVWMVSILIAIPSAYFTTetvLFIVKSQEKIFCGQIWPVDQQLYY 248
Cdd:cd14985    88 IFLLTCMSVDRYLAIVHPVAsrRLRRRRQARVTCALIWVVACLLSLPTFLLRS---LQAIENLNKTACIMLYPHEAWHFG 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 249 KSYFLFIFGieFVGPVVTMTLCYARISRELWFKavpgfqTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYGFT----- 323
Cdd:cd14985   165 LSLELNILG--FVLPLLIILTCYFHIARSLRKR------YERTGKNGRKRRKSLKIIFALVVAFLVCWLPFHFFKfldfl 236
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1048478233 324 ----IVRDFFPTVFIKekhylTAFYVVECIAMSNSMINTVCFVTVKN 366
Cdd:cd14985   237 aqlgAIRPCFWELFLD-----LGLPIATCLAFTNSCLNPFIYVFVDR 278
7tmA_SSTR1 cd15970
somatostatin receptor type 1, member of the class A family of seven-transmembrane G ...
82-372 2.51e-28

somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.


Pssm-ID: 320636 [Multi-domain]  Cd Length: 276  Bit Score: 112.31  E-value: 2.51e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233  82 IVIGVALAGIMLVCGIGNFVFIAALARYKKLRNLTNLLIANLAISDFLVaIICCPFEMDYYVVRQlsWEHGHVLCASVNY 161
Cdd:cd15970     1 ILISFIYSVVCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIADELL-MLSVPFLVTSTLLRH--WPFGSLLCRLVLS 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 162 LRTVSLYVSTNALLAIALDRYLAIVHPLK-PRMNYQTASFLIAL-VWMVSILIAIPSAYFTTETvlfiVKSQEKIFCGQI 239
Cdd:cd15970    78 VDAINMFTSIYCLTVLSIDRYIAVVHPIKaARYRRPTVAKMVNLgVWVFSILVILPIIIFSNTA----PNSDGSVACNMQ 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 240 WPVDQQLYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAV-PGFQteqirKRLRCRRKTVLVLMCILTAYVLCWAP 318
Cdd:cd15970   154 MPEPSQRWLAVFVVYTFLMGFLLPVIAICLCYILIIVKMRVVALkAGWQ-----QRKRSERKITLMVMMVVTVFVICWMP 228
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1048478233 319 FYGFTIVrdffpTVFIkEKHYLTAFYVVECIAMSNSMINTVCFVTVKNNTMKYF 372
Cdd:cd15970   229 FYVVQLV-----SVFV-GQHDATVSQLSVILGYANSCANPILYGFLSDNFKRSF 276
7tmA_NPY1R cd15395
neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G ...
82-359 8.43e-28

neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320517  Cd Length: 293  Bit Score: 111.06  E-value: 8.43e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233  82 IVIGVALAGIMLVCGIGNFVFIAALARYKKLRNLTNLLIANLAISDFLVAIICCPFEMDYYVVRQlsWEHGHVLCASVNY 161
Cdd:cd15395     1 FTLALAYSAVIILGVSGNLALIIIILKQKEMHNVTNILIVNLSFSDLLMTIMCLPFTFVYTLMDH--WVFGEAMCKLNSM 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 162 LRTVSLYVSTNALLAIALDRYLAIVHPLKPRMNYQTASFLIALVWMVSILIAIPSAYF---TTETVLFIVKSQE----KI 234
Cdd:cd15395    79 VQCISITVSIFSLVLIAIERHQLIINPRGWRPNNRHAYVGIAVIWVLAVLTSLPFLIFqvlTDEPFKNVNVSLDaykgKY 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 235 FCGQIWPVDQQLYykSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPGFQTEQIRKRLRCRRKTVLVLMCILTAYVL 314
Cdd:cd15395   159 VCLDQFPSDTIRL--SYTTCLLVLQYFGPLCFIFICYLKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLISIVVAFAV 236
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1048478233 315 CWAPFYGFTIVRDFFPTVFIKEKHYLTaFYVVECIAMSNSMINTV 359
Cdd:cd15395   237 CWLPLNIFNAVFDWNHEAIATCNHNLL-FLICHLTAMISTCVNPI 280
7tmA_ET_R-like cd14977
endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...
82-372 1.46e-27

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.


Pssm-ID: 320108 [Multi-domain]  Cd Length: 292  Bit Score: 110.59  E-value: 1.46e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233  82 IVIGVALAgIMLVCGIGNFVFIAALARYKKLRNLTNLLIANLAISDFLVAIICCPFEMDYYVVRQlsWEHGHVLCASVNY 161
Cdd:cd14977     2 VIMSLSLV-IFAVGIIGNLMVLCIVCTNYYMRSVPNILIASLALGDLLLLLLCVPLNAYNLLTKD--WLFGDVMCKLVPF 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 162 LRTVSLYVSTNALLAIALDRYLAIV--HPLKPRMNYQTASFLIALVWMVSILIAIPSAYFTTETVLFIVKSQEKIFCG-Q 238
Cdd:cd14977    79 IQVTSLGVTVFSLCALSIDRYRAAVnsMPMQTIGACLSTCVKLAVIWVGSVLLAVPEAVLSTVARESSLDNSSLTVCImK 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 239 IWPVDQQLYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPGfqTEQIRKRLRCRRKTVLVLMCILTAYVLCWAP 318
Cdd:cd14977   159 PSTPFAETYPKARSWWLFGCYFCLPLAFTAVCYLLMARTLIRAAKEY--TRGTKKHMKQRRQLAKTVLCLVLVFAFCWLP 236
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1048478233 319 FYGFTIVRDFFPT-VFIKEKHYLT-AFYVVECIAMSNSMINTVCFVTVKNNTMKYF 372
Cdd:cd14977   237 EHISNILRATLYNeVLIDTRSTLDiLDLIGQFLSFFNSCVNPIALYLLSEPFRRAF 292
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
80-361 2.49e-27

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in nuemerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 109.83  E-value: 2.49e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233  80 AKIVIgvaLAGIMLVCGIGNFVFIAALARYKKLRNLTNLLIANLAISDFLVAIICCPFEMDY-YVVrqlSWEHGHVLCAS 158
Cdd:cd15384     2 LKIVV---LAVMFVISFIGNLLTIIQIYRLRRSRRTIYSLLLHLAIADLLVTFFCIPSEAIWaYTV---AWLAGNTMCKL 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 159 VNYLRTVSLYVSTNALLAIALDRYLAIVHPLKPRMNYQTASFLIALVWMVSILIAIPSAYFTTETVLFIVKSQEKI---- 234
Cdd:cd15384    76 VKYLQVFGLYLSTYITVLISLDRCVAILYPMKRNQAPERVRRMVTVAWILSPIFSIPQAVIFHVERGPFVEDFHQCvtyg 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 235 FCGQIWpvDQQLYYKSYFLFIFGIefvgPVVTMTLCYARISRELwFKAVPGFQTE--------QIRKRL--RCRRKTVLV 304
Cdd:cd15384   156 FYTAEW--QEQLYNMLSLVFMFPI----PLVIMVTCYVLIFITL-SKSSRDFQGLeiytrnrgPNRQRLfhKAKVKSLRM 228
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1048478233 305 LMCILTAYVLCWAPFYGFTIVRDFFPTVFIKEKHYLTAFYvvecIAMSNSMINTVCF 361
Cdd:cd15384   229 SAVIVTAFILCWTPYYVIMIWFLFFNPYPLNDILFDVIFF----FGMSNSCVNPLIY 281
7tmA_NPFFR2 cd15980
neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G ...
91-328 3.43e-27

neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320646 [Multi-domain]  Cd Length: 299  Bit Score: 109.59  E-value: 3.43e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233  91 IMLVCGIGNFVFIAALARYKKLRNLTNLLIANLAISDFLVAIICCPFEMDYYVVRqlSWEHGHVLCASVNYLRTVSLYVS 170
Cdd:cd15980    10 IFLLCMMGNGVVCFIVLRSKHMRTVTNLFILNLAISDLLVGIFCMPTTLLDNIIA--GWPFGSTVCKMSGMVQGISVSAS 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 171 TNALLAIALDRYLAIVHPLKPRMNYQTASFLIALVWMVSILIAIPSAYF--TTETVLFIV------KSQEKIFCGQIWPv 242
Cdd:cd15980    88 VFTLVAIAVDRFRCIVYPFKQKLTISTAVVIIVIIWVLAIAIMCPSAVMlhVQEEKNYRVvlgsqnKTSPVYWCREDWP- 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 243 dQQLYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVP-GFQTEQIRKRLRCRRKTVLVLMCILTA--YVLCWAPF 319
Cdd:cd15980   167 -NQEMRKIYTTVLFANIYLAPLSLIVIMYARIGITLFKTAMPhTGKHNQEQRHVVSRKKQKVIKMLLIVAllFILSWLPL 245

                  ....*....
gi 1048478233 320 YGFTIVRDF 328
Cdd:cd15980   246 WTLMMLSDY 254
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
82-334 4.01e-27

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 320100 [Multi-domain]  Cd Length: 284  Bit Score: 109.22  E-value: 4.01e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233  82 IVIGVALAGIMLVCGIGNFVFIAALARYKKLRNLTNLLIANLAISDFLVAIICCPFEMDYYVVRQLSWehGHVLCASVNY 161
Cdd:cd14969     1 YVLAVYLSLIGVLGVVLNGLVILVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSF--GDPGCVIYGF 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 162 LRTVSLYVSTNALLAIALDRYLAIVHPLKP-RMNYQTASFLIALVWMVSILIAIP-----SAYfTTETVlfivksqeKIF 235
Cdd:cd14969    79 AVTFLGLVSISTLAALAFERYLVIVRPLKAfRLSKRRALILIAFIWLYGLFWALPplfgwSSY-VPEGG--------GTS 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 236 CGQIWpVDQQLYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFK---AVPGFQTEQIRKRLRCRRKTVLVLMCILTAY 312
Cdd:cd14969   150 CSVDW-YSKDPNSLSYIVSLFVFCFFLPLAIIIFCYYKIYRTLRKMskrAARRKNSAITKRTKKAEKKVAKMVLVMIVAF 228
                         250       260
                  ....*....|....*....|..
gi 1048478233 313 VLCWAPFYGFTIVRDFFPTVFI 334
Cdd:cd14969   229 LIAWTPYAVVSLYVSFGGESTI 250
7tmA_NPY6R cd15396
neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G ...
86-370 1.41e-26

neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320518  Cd Length: 293  Bit Score: 107.61  E-value: 1.41e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233  86 VALAGIMLVCGIGNFVFIAALARYKKLRNLTNLLIANLAISDFLVAIICCPFEMDYYVVRQlsWEHGHVLCASVNYLRTV 165
Cdd:cd15396     5 IAYSVVTIVGLFGNLCLITIIKKQKEEHNVTNILIANLSLSDVLVCVMCIPFTAVYTLMDH--WIFGETMCKLTSFVQSV 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 166 SLYVSTNALLAIALDRYLAIVHPLKPRMNYQTASFLIALVWMVSILIAIPSAYF---TTETVLFIVKSQE----KIFCGQ 238
Cdd:cd15396    83 SVSVSIFSLVLIAIERYQLIVNPRGWKPSASHAYWGIVLIWLFSLMISIPFLIFhqlTDEPFRNLSSHSDfykdKVVCIE 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 239 IWP--VDQQLYYKSYFLFifgiEFVGPVVTMTLCYARISRELWFKAVPGFQTEQIRKRLRCRRKTVLVLMCILTAYVLCW 316
Cdd:cd15396   163 AWPseTERLIFTTSLLVF----QYFVPLGFIFICYLKIFVCLKKRNSKIDRMRENESRLSENKRINTMLISIVVTFAACW 238
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1048478233 317 APFYGFTIVRDFFPTVFIKEKHYLtAFYVVECIAMSNSMINTVCFVTVKNNTMK 370
Cdd:cd15396   239 LPLNIFNVVFDWNHEVLMSCHHNL-VFTLCHLVAMVSTCINPIFYGFLNKNFQK 291
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
93-372 5.47e-26

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221 [Multi-domain]  Cd Length: 280  Bit Score: 106.01  E-value: 5.47e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233  93 LVCGIG---NFVFIAALARYKKLRNLTNLLIANLAISDFLVaIICCPFEMDYYVVRQlsWEHGHVLCASVNYLRTVSLYV 169
Cdd:cd15093     9 VVCLVGlcgNSLVIYVVLRYAKMKTVTNIYILNLAIADELF-MLGLPFLAASNALRH--WPFGSVLCRLVLSVDGINMFT 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 170 STNALLAIALDRYLAIVHPLK------PRmnyqTASFLIALVWMVSILIAIPSAYFTTETvlfiVKSQEKIFCGQIWPVD 243
Cdd:cd15093    86 SIFCLTVMSVDRYLAVVHPIKsarwrrPR----VAKVVNLAVWVASLLVILPVVVFAGTR----ENQDGSSACNMQWPEP 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233 244 QQLYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAV-PGFQteqirKRLRCRRKTVLVLMCILTAYVLCWAPFYGF 322
Cdd:cd15093   158 AAAWSAGFIIYTFVLGFLLPLLIICLCYLLIVIKVKSAGLrAGWQ-----QRKRSERKVTRMVVMVVVVFVICWLPFYVL 232
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1048478233 323 TIVRDFFPtvFIKEKHYLTAFYVVECIAMSNSMINTVCFVTVKNNTMKYF 372
Cdd:cd15093   233 QLVNVFVQ--LPETPALVGVYHFVVILSYANSCANPILYGFLSDNFKKSF 280
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
82-370 6.22e-26

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 105.61  E-value: 6.22e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1048478233  82 IVIGVALAGIMLVCGIGNFVFIAALARYKKLRNLTNLLIANLAISDfLVAIICCPFeMDYYVVRQLSWEHGHVLCASVNY 161
Cdd:cd15088     1 VIMPSVFGCICVV</