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Conserved domains on  [gi|1050396602|gb|OCT98792|]
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hypothetical protein XELAEV_18011026mg [Xenopus laevis]

Protein Classification

EpoR_lig-bind and FN3 domain-containing protein( domain architecture ID 10557304)

EpoR_lig-bind and FN3 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EpoR_lig-bind pfam09067
Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin ...
 24-123 1.19e-42

Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin (EPO), with subsequent initiation of the downstream chain of events associated with binding of EPO to the receptor, including EPO-induced erythroblast proliferation and differentiation through induction of the JAK2/STAT5 signaling cascade. The domain adopts a secondary structure composed of a short amino-terminal helix, followed by two beta-sandwich regions.


:

Pssm-ID: 401127  Cd Length: 104  Bit Score: 148.72  E-value: 1.19e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050396602  24 SLNAQSPPGKPEIIKCRSYEKVTFSCWWKPASDGGLPTNYSLLYRKENDpKIYECPDYETSGLNS-----CYFDKAHTSF 98
Cdd:pfam09067   1 SQAALLLPEKPEDIKCFSREKEDFTCFWEEEEDGGLPTTYSFSYAYENE-TVKECPLYSTSGANStrlfiCFFPKNDVSL 79

                          90       100
                  ....*....|....*....|....*
gi 1050396602  99 WVFYHIYVNATNALGSNVSEELSVD 123
Cdd:pfam09067  80 FVPLHITVVATNTNGTRYSRELSVE 104
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 132-225 7.15e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 59.05  E-value: 7.15e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050396602 132 PPTNLSLTVEDGHHdLLVKWHPPDmadvQSGWLTLKYEVRLKEEKEQEWEAHSV--GNQLKLKLYGLTPGGNYVVQVRCK 209
Cdd:cd00063     3 PPTNLRVTDVTSTS-VTLSWTPPE----DDGGPITGYVVEYREKGSGDWKEVEVtpGSETSYTLTGLKPGTEYEFRVRAV 77

                          90
                  ....*....|....*.
gi 1050396602 210 pDSGHWSEWSQESYIQ 225
Cdd:cd00063    78 -NGGGESPPSESVTVT 92
 
Name Accession Description Interval E-value
EpoR_lig-bind pfam09067
Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin ...
 24-123 1.19e-42

Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin (EPO), with subsequent initiation of the downstream chain of events associated with binding of EPO to the receptor, including EPO-induced erythroblast proliferation and differentiation through induction of the JAK2/STAT5 signaling cascade. The domain adopts a secondary structure composed of a short amino-terminal helix, followed by two beta-sandwich regions.


Pssm-ID: 401127  Cd Length: 104  Bit Score: 148.72  E-value: 1.19e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050396602  24 SLNAQSPPGKPEIIKCRSYEKVTFSCWWKPASDGGLPTNYSLLYRKENDpKIYECPDYETSGLNS-----CYFDKAHTSF 98
Cdd:pfam09067   1 SQAALLLPEKPEDIKCFSREKEDFTCFWEEEEDGGLPTTYSFSYAYENE-TVKECPLYSTSGANStrlfiCFFPKNDVSL 79

                          90       100
                  ....*....|....*....|....*
gi 1050396602  99 WVFYHIYVNATNALGSNVSEELSVD 123
Cdd:pfam09067  80 FVPLHITVVATNTNGTRYSRELSVE 104
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 132-225 7.15e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 59.05  E-value: 7.15e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050396602 132 PPTNLSLTVEDGHHdLLVKWHPPDmadvQSGWLTLKYEVRLKEEKEQEWEAHSV--GNQLKLKLYGLTPGGNYVVQVRCK 209
Cdd:cd00063     3 PPTNLRVTDVTSTS-VTLSWTPPE----DDGGPITGYVVEYREKGSGDWKEVEVtpGSETSYTLTGLKPGTEYEFRVRAV 77

                          90
                  ....*....|....*.
gi 1050396602 210 pDSGHWSEWSQESYIQ 225
Cdd:cd00063    78 -NGGGESPPSESVTVT 92
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 132-213 1.45e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.15  E-value: 1.45e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050396602  132 PPTNLSLTvEDGHHDLLVKWHPPDmaDVQSGWLTLKYEVRLKEEKEQEWEAHSVGNQLKLKLYGLTPGGNYVVQVRCKPD 211
Cdd:smart00060   3 PPSNLRVT-DVTSTSVTLSWEPPP--DDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                   ..
gi 1050396602  212 SG 213
Cdd:smart00060  80 AG 81
fn3 pfam00041
Fibronectin type III domain;
132-219 2.91e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 48.57  E-value: 2.91e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050396602 132 PPTNLSLTvEDGHHDLLVKWHPPDMADVQSgwltLKYEVRLKEEKEQEWEAHS--VGNQLKLKLYGLTPGGNYVVQVRCK 209
Cdd:pfam00041   2 APSNLTVT-DVTSTSLTVSWTPPPDGNGPI----TGYEVEYRPKNSGEPWNEItvPGTTTSVTLTGLKPGTEYEVRVQAV 76

                          90
                  ....*....|
gi 1050396602 210 PDSGhWSEWS 219
Cdd:pfam00041  77 NGGG-EGPPS 85
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
30-248 3.78e-05

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 46.53  E-value: 3.78e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050396602  30 PPGKPEIIKCRSY--EKVTFScwWKPASDGGLpTNYSLlYRKENDPKIYEcpdYETSGLNSCYFDK----AHTsfwvfYH 103
Cdd:COG3401   232 PPSAPTGLTATADtpGSVTLS--WDPVTESDA-TGYRV-YRSNSGDGPFT---KVATVTTTSYTDTgltnGTT-----YY 299

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050396602 104 IYVNATNALG--SNVSEELSVdTTYIVETYPPTNLSLTVEDGHhDLLVKWHPPDMADVQSgwltlkYEVRLKEEKEQEWE 181
Cdd:COG3401   300 YRVTAVDAAGneSAPSNVVSV-TTDLTPPAAPSGLTATAVGSS-SITLSWTASSDADVTG------YNVYRSTSGGGTYT 371

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1050396602 182 A-HSVGNQLKLKLYGLTPGGNYVVQVRCKPDSGHWSEWSQESYIQILGGGKKTDLMLWISVGTLSAVI 248
Cdd:COG3401   372 KiAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTASAASGESLTASVDAVPLTDVA 439
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 31-124 2.70e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 37.48  E-value: 2.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050396602  31 PGKPEIIKCRSYEKVTFSCWWK-PASDGGLPTNYSLLYRKENDPKIYECpdyETSGLNSCYFD----KAHTSfwvfYHIY 105
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTpPEDDGGPITGYVVEYREKGSGDWKEV---EVTPGSETSYTltglKPGTE----YEFR 73

                          90       100
                  ....*....|....*....|
gi 1050396602 106 VNATNALG-SNVSEELSVDT 124
Cdd:cd00063    74 VRAVNGGGeSPPSESVTVTT 93
 
Name Accession Description Interval E-value
EpoR_lig-bind pfam09067
Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin ...
 24-123 1.19e-42

Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin (EPO), with subsequent initiation of the downstream chain of events associated with binding of EPO to the receptor, including EPO-induced erythroblast proliferation and differentiation through induction of the JAK2/STAT5 signaling cascade. The domain adopts a secondary structure composed of a short amino-terminal helix, followed by two beta-sandwich regions.


Pssm-ID: 401127  Cd Length: 104  Bit Score: 148.72  E-value: 1.19e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050396602  24 SLNAQSPPGKPEIIKCRSYEKVTFSCWWKPASDGGLPTNYSLLYRKENDpKIYECPDYETSGLNS-----CYFDKAHTSF 98
Cdd:pfam09067   1 SQAALLLPEKPEDIKCFSREKEDFTCFWEEEEDGGLPTTYSFSYAYENE-TVKECPLYSTSGANStrlfiCFFPKNDVSL 79

                          90       100
                  ....*....|....*....|....*
gi 1050396602  99 WVFYHIYVNATNALGSNVSEELSVD 123
Cdd:pfam09067  80 FVPLHITVVATNTNGTRYSRELSVE 104
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 132-225 7.15e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 59.05  E-value: 7.15e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050396602 132 PPTNLSLTVEDGHHdLLVKWHPPDmadvQSGWLTLKYEVRLKEEKEQEWEAHSV--GNQLKLKLYGLTPGGNYVVQVRCK 209
Cdd:cd00063     3 PPTNLRVTDVTSTS-VTLSWTPPE----DDGGPITGYVVEYREKGSGDWKEVEVtpGSETSYTLTGLKPGTEYEFRVRAV 77

                          90
                  ....*....|....*.
gi 1050396602 210 pDSGHWSEWSQESYIQ 225
Cdd:cd00063    78 -NGGGESPPSESVTVT 92
IL6Ra-bind pfam09240
Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure ...
 38-127 1.23e-07

Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure consisting of an immunoglobulin-like beta-sandwich, with seven strands in two beta-sheets, in a Greek-key topology. They are required for binding to the cytokine Interleukin-6.


Pssm-ID: 401252  Cd Length: 96  Bit Score: 49.72  E-value: 1.23e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050396602  38 KCRSYEKVTFSCWWKPASDGGLPTNYSLLYRKENDPKIYECPDY-ETSGLN-SCYFDKAHTSFWVFYHIY--VNATNALG 113
Cdd:pfam09240   3 TCFIHNPSNLSCEWKPGPNAPPDTNYVLYVRKSPLGPVLQCQYYiRDDGTRiGCQFDDLEGLSSSFHQVYicVNGSSSAG 82

                          90
                  ....*....|....
gi 1050396602 114 SNVSEELSVDTTYI 127
Cdd:pfam09240  83 PIRSSDQTFQLQNI 96
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 132-213 1.45e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.15  E-value: 1.45e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050396602  132 PPTNLSLTvEDGHHDLLVKWHPPDmaDVQSGWLTLKYEVRLKEEKEQEWEAHSVGNQLKLKLYGLTPGGNYVVQVRCKPD 211
Cdd:smart00060   3 PPSNLRVT-DVTSTSVTLSWEPPP--DDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                   ..
gi 1050396602  212 SG 213
Cdd:smart00060  80 AG 81
fn3 pfam00041
Fibronectin type III domain;
132-219 2.91e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 48.57  E-value: 2.91e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050396602 132 PPTNLSLTvEDGHHDLLVKWHPPDMADVQSgwltLKYEVRLKEEKEQEWEAHS--VGNQLKLKLYGLTPGGNYVVQVRCK 209
Cdd:pfam00041   2 APSNLTVT-DVTSTSLTVSWTPPPDGNGPI----TGYEVEYRPKNSGEPWNEItvPGTTTSVTLTGLKPGTEYEVRVQAV 76

                          90
                  ....*....|
gi 1050396602 210 PDSGhWSEWS 219
Cdd:pfam00041  77 NGGG-EGPPS 85
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
30-248 3.78e-05

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 46.53  E-value: 3.78e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050396602  30 PPGKPEIIKCRSY--EKVTFScwWKPASDGGLpTNYSLlYRKENDPKIYEcpdYETSGLNSCYFDK----AHTsfwvfYH 103
Cdd:COG3401   232 PPSAPTGLTATADtpGSVTLS--WDPVTESDA-TGYRV-YRSNSGDGPFT---KVATVTTTSYTDTgltnGTT-----YY 299

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050396602 104 IYVNATNALG--SNVSEELSVdTTYIVETYPPTNLSLTVEDGHhDLLVKWHPPDMADVQSgwltlkYEVRLKEEKEQEWE 181
Cdd:COG3401   300 YRVTAVDAAGneSAPSNVVSV-TTDLTPPAAPSGLTATAVGSS-SITLSWTASSDADVTG------YNVYRSTSGGGTYT 371

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1050396602 182 A-HSVGNQLKLKLYGLTPGGNYVVQVRCKPDSGHWSEWSQESYIQILGGGKKTDLMLWISVGTLSAVI 248
Cdd:COG3401   372 KiAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTASAASGESLTASVDAVPLTDVA 439
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 31-124 2.70e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 37.48  E-value: 2.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050396602  31 PGKPEIIKCRSYEKVTFSCWWK-PASDGGLPTNYSLLYRKENDPKIYECpdyETSGLNSCYFD----KAHTSfwvfYHIY 105
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTpPEDDGGPITGYVVEYREKGSGDWKEV---EVTPGSETSYTltglKPGTE----YEFR 73

                          90       100
                  ....*....|....*....|
gi 1050396602 106 VNATNALG-SNVSEELSVDT 124
Cdd:cd00063    74 VRAVNGGGeSPPSESVTVTT 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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