|
Name |
Accession |
Description |
Interval |
E-value |
| Cys_Met_Meta_PP |
pfam01053 |
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and ... |
19-395 |
0e+00 |
|
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and methionine metabolism. The following are members: Cystathionine gamma-lyase, Cystathionine gamma-synthase, Cystathionine beta-lyase, Methionine gamma-lyase, OAH/OAS sulfhydrylase, O-succinylhomoserine sulfhydrylase All of these members participate is slightly different reactions. All these enzymes use PLP (pyridoxal-5'-phosphate) as a cofactor.
Pssm-ID: 395837 [Multi-domain] Cd Length: 376 Bit Score: 610.77 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 19 ATQAIHVGQEPEQwTSRAVVPLISLSTTFKQEAPGQHSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAFASGLAA-TVTI 97
Cdd:pfam01053 1 DTLAVHAGQRPDP-QTGAVSVPIYLTSTYVFDFAGEEGGYDYSRSGNPTRDVLEERIAALEGGAAALAFSSGMAAiTAAI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 98 THLLKAGDQIICVDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPILKMIDIEACAHIVH 177
Cdd:pfam01053 80 LALLKAGDHIVATDDLYGGTYRLFNKVLPRFGIEVTFVDTSDPEDLEAAIKPNTKAVYLETPTNPLLKVVDIEAIAKLAK 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 178 KHGdIILVVDNTFMSPYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVNCERLHNRLRFLQNSLGAVPSPLDCYLCNR 257
Cdd:pfam01053 160 KHG-ILVVVDNTFASPYLQRPLDLGADIVVHSATKYIGGHSDVVGGVIVVNGEELGKELYFLQNATGAVLSPFDAWLLLR 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 258 GLKTLHVRMEKHFKNGMAVAQFLESNPGVEKVIYPGLPSHPQHELAKRQCTGCTGMITFYIKGTLQHAEIFLKNLKLFTL 337
Cdd:pfam01053 239 GLKTLGLRMEQHQENAQKVAEFLESHPKVEKVYYPGLPSHPGHELAKRQMKGFGGMLSFELKGGLEAAKKFLDNLKLFSL 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1059158380 338 AESLGGFESLAELPAIMTHASVPKNDRDVLGISDTLIRLSVGLEDEKDLLEDLDQALK 395
Cdd:pfam01053 319 AVSLGGVESLISHPATMTHASIPPEEREAAGITDDLIRLSVGIEDVDDLIADLKQALE 376
|
|
| MetC |
COG0626 |
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; ... |
16-397 |
0e+00 |
|
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; Cystathionine beta-lyase/cystathionine gamma-synthase is part of the Pathway/BioSystem: Methionine biosynthesis
Pssm-ID: 440391 [Multi-domain] Cd Length: 389 Bit Score: 595.49 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 16 QHFATQAIHVGQEPEQWTsRAVVPLISLSTTFKQEAPGQ--------HSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAF 87
Cdd:COG0626 1 MGPATRAVHAGRDPDPQT-GAVSPPIYLTSTFVFPSAEAlaarfageEGGYIYSRYGNPTRRALEEALAALEGGEAALAF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 88 ASGLAA-TVTITHLLKAGDQIICVDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPILKM 166
Cdd:COG0626 80 ASGMAAiSAVLLALLKAGDHVVASDDLYGGTRRLLDKVLARFGIEVTFVDPTDLAAVEAAIRPNTKLVFLETPSNPTLEV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 167 IDIEACAHIVHKHGdIILVVDNTFMSPYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVNCERLHNRLRFLQNSLGAV 246
Cdd:COG0626 160 VDIAAIAAIAHAAG-ALLVVDNTFATPLLQRPLELGADIVVHSATKYLGGHSDVLGGAVVGRDEELAERLRFLQNALGAV 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 247 PSPLDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPGVEKVIYPGLPSHPQHELAKRQCTGCTGMITFYIKGTLQHAE 326
Cdd:COG0626 239 LSPFDAWLLLRGLKTLALRMERHCENALAVAEWLEAHPAVARVYYPGLPSHPGHELAKRQMSGFGGMLSFELKGGREAAR 318
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1059158380 327 IFLKNLKLFTLAESLGGFESLAELPAIMTHASVPKNDRDVLGISDTLIRLSVGLEDEKDLLEDLDQALKAA 397
Cdd:COG0626 319 RFLDALKLFTLAVSLGGVESLITHPATMTHRSLPPEERAALGITDGLVRLSVGLEDVDDLIADLEQALAAL 389
|
|
| CGS_like |
cd00614 |
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed ... |
36-395 |
0e+00 |
|
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of antimicrobials and herbicides. This subgroup also includes cystathionine gamma-lyases (CGL), O-acetylhomoserine sulfhydrylases and O-acetylhomoserine thiol lyases. CGL's are very similar to CGS's. Members of this group are widely distributed among all three forms of life.
Pssm-ID: 99738 [Multi-domain] Cd Length: 369 Bit Score: 572.61 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 36 AVVPLISLSTTFKQEAP--------GQHSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAFASGLAA-TVTITHLLKAGDQ 106
Cdd:cd00614 2 AVAPPIYQTSTFVFPSPaeaadlfaLREGGYIYSRIGNPTVDALEKKLAALEGGEAALAFSSGMAAiSTVLLALLKAGDH 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 107 IICVDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPILKMIDIEACAHIVHKHGdIILVV 186
Cdd:cd00614 82 VVASDDLYGGTYRLFERLLPKLGIEVTFVDPDDPEALEAAIKPETKLVYVESPTNPTLKVVDIEAIAELAHEHG-ALLVV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 187 DNTFMSPYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVNCERLHNRLRFLQNSLGAVPSPLDCYLCNRGLKTLHVRM 266
Cdd:cd00614 161 DNTFATPYLQRPLELGADIVVHSATKYIGGHSDVIAGVVVGSGEALIQRLRFLRLALGTILSPFDAWLLLRGLKTLPLRM 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 267 EKHFKNGMAVAQFLESNPGVEKVIYPGLPSHPQHELAKRQCTGCTGMITFYIKGTLQHAEIFLKNLKLFTLAESLGGFES 346
Cdd:cd00614 241 ERHSENALKVAEFLEKHPKVERVYYPGLPSHPQHELAKKQMSGYGGVFSFELKGGLEAAKKFLNALKLFSLAVSLGGVES 320
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 1059158380 347 LAELPAIMTHASVPKNDRDVLGISDTLIRLSVGLEDEKDLLEDLDQALK 395
Cdd:cd00614 321 LVEHPASMTHSQLPPEERAAAGITPGLVRLSVGIEDVEDLIADLEQALK 369
|
|
| PRK07811 |
PRK07811 |
cystathionine gamma-synthase; Provisional |
13-396 |
7.08e-174 |
|
cystathionine gamma-synthase; Provisional
Pssm-ID: 236104 [Multi-domain] Cd Length: 388 Bit Score: 492.24 E-value: 7.08e-174
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 13 PHFQHFATQAIHVGQEPEQWTSrAVVPLISLSTTFKQEAPGQ-HSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAFASGL 91
Cdd:PRK07811 8 HANQGFATRAIHAGYEPDPATG-AVNPPIYASSTFAQDGVGGlRGGYEYARTGNPTRTALEEQLAALEGGAYGRAFSSGM 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 92 AAT-VTITHLLKAGDQIICVDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPILKMIDIE 170
Cdd:PRK07811 87 AATdCLLRAVLRPGDHIVIPNDAYGGTFRLIDKVFTRWGVEYTPVDLSDLDAVRAAITPRTKLIWVETPTNPLLSITDIA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 171 ACAHIVHKHGdIILVVDNTFMSPYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVNCERLHNRLRFLQNSLGAVPSPL 250
Cdd:PRK07811 167 ALAELAHDAG-AKVVVDNTFASPYLQQPLALGADVVVHSTTKYIGGHSDVVGGALVTNDEELDEAFAFLQNGAGAVPGPF 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 251 DCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPGVEKVIYPGLPSHPQHELAKRQCTGCTGMITFYIKGTLQHAEIFLK 330
Cdd:PRK07811 246 DAYLTLRGLKTLAVRMDRHSENAEAVAEFLAGHPEVSTVLYPGLPSHPGHEVAARQMRGFGGMVSVRLAGGEEAARDFCA 325
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1059158380 331 NLKLFTLAESLGGFESLAELPAIMTHASVPKNDrdvLGISDTLIRLSVGLEDEKDLLEDLDQALKA 396
Cdd:PRK07811 326 RTKVFTLAESLGGVESLIEHPSAMTHASTAGSQ---LEVPDDLVRLSVGIEDVADLLADLEQALGQ 388
|
|
| PRK07671 |
PRK07671 |
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase; |
20-395 |
1.01e-163 |
|
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase;
Pssm-ID: 181076 [Multi-domain] Cd Length: 377 Bit Score: 466.12 E-value: 1.01e-163
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 20 TQAIHVGQEPEQWTSRAVVPLISLSTtFKQEAPGQHSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAFASGLAATVTITH 99
Cdd:PRK07671 5 TKLIHGGIIGDPSTGAVSVPIYQVST-YKQEAVGKHQGYEYSRTGNPTRAALEELIAVLEGGHAGFAFGSGMAAITAVMM 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 100 LLKAGDQIICVDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPILKMIDIEACAHIVHKH 179
Cdd:PRK07671 84 LFSSGDHVILTDDVYGGTYRVMTKVLNRFGIEHTFVDTSNLEEVEEAIRPNTKAIYVETPTNPLLKITDIKKISTIAKEK 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 180 GdIILVVDNTFMSPYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVNCERLHNRLRFLQNSLGAVPSPLDCYLCNRGL 259
Cdd:PRK07671 164 G-LLTIVDNTFMTPYWQSPISLGADIVLHSATKYLGGHSDVVAGLVVVNSPELAEDLHFVQNSTGGILGPQDSWLLLRGL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 260 KTLHVRMEKHFKNGMAVAQFLESNPGVEKVIYPGLPSHPQHELAKRQCTGCTGMITFYIkGTLQHAEIFLKNLKLFTLAE 339
Cdd:PRK07671 243 KTLGIRMEEHETNSRAIAEFLNNHPAVNKVYYPGLPSHPNHELAKEQANGFGGMISFDV-GSEETANKVLERLQYFTLAE 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1059158380 340 SLGGFESLAELPAIMTHASVPKNDRDVLGISDTLIRLSVGLEDEKDLLEDLDQALK 395
Cdd:PRK07671 322 SLGAVESLISIPSQMTHASIPADRRKELGITDGLIRISVGIEDGEDLIEDLAQALA 377
|
|
| PRK06176 |
PRK06176 |
cystathionine gamma-synthase; |
17-396 |
3.37e-152 |
|
cystathionine gamma-synthase;
Pssm-ID: 180443 [Multi-domain] Cd Length: 380 Bit Score: 437.02 E-value: 3.37e-152
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 17 HFATQAIHVGQEPEQWTSRAVVPlISLSTTFKQEAPGQHSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAFASGLAATVT 96
Cdd:PRK06176 2 RMQTKLIHGGISEDTTTGAVSVP-IYQTSTYRQDAIGRPKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASGLAGIHA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 97 ITHLLKAGDQIICVDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPILKMIDIEACAHIV 176
Cdd:PRK06176 81 VFSLFQSGDHVLLGDDVYGGTFRLFDKVLVKNGLSCTIIDTSDLSQIKKAIKPNTKALYLETPSNPLLKITDLAQCASVA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 177 HKHGdIILVVDNTFMSPYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVNCERLHNRLRFLQNSLGAVPSPLDCYLCN 256
Cdd:PRK06176 161 KDHG-LLTIVDNTFATPYYQNPLLLGADIVVHSGTKYLGGHSDVVAGLVTTNNEALAQEIAFFQNAIGGVLGPQDSWLLQ 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 257 RGLKTLHVRMEKHFKNGMAVAQFLESNPGVEKVIYPGLPSHPQHELAKRQCTGCTGMITFYIKGTLQhAEIFLKNLKLFT 336
Cdd:PRK06176 240 RGIKTLGLRMEAHQKNALCVAEFLEKHPKVEKVYYPGLPTHPNHELAKKQMRGFSGMLSFTLKNDSE-AVAFVESLKLFI 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 337 LAESLGGFESLAELPAIMTHASVPKNDRDVLGISDTLIRLSVGLEDEKDLLEDLDQALKA 396
Cdd:PRK06176 319 LGESLGGVESLVGIPAFMTHACIPKEQREAAGIRDGLVRLSVGIEHEQDLLEDLEQAFAK 378
|
|
| cysta_beta_ly_E |
TIGR01329 |
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase ... |
19-397 |
1.24e-130 |
|
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys.
Pssm-ID: 273557 [Multi-domain] Cd Length: 378 Bit Score: 381.87 E-value: 1.24e-130
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 19 ATQAIHVGQEPEQWTsrAVVPLISLSTTFKQEAPGQHSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAFASGLAATVTIT 98
Cdd:TIGR01329 2 STLLVNTDNKNDPYD--ASSMPIYQTATFKQPLAIENGPYDYTRSGNPTRTALESLLAKLDKADRAFAFSSGMAALDVIT 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 99 HLLKAGDQIICVDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPILKMIDIEACAHIVHK 178
Cdd:TIGR01329 80 RLLNNGDEIIAGDDLYGGTDRLLTQVVPRSGVVVVHVDTTDLDKVKAALGPKTKLVLLESPTNPLQKIVDIRKISEMAHA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 179 HGdIILVVDNTFMSPYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVNCERLHNRLRFLQNSLGAVPSPLDCYLCNRG 258
Cdd:TIGR01329 160 QN-ALVVVDNTMMSPLLCNPLELGADIVYHSATKFLAGHSDVMAGVLAVKGEEIAKKVYFLQNSTGSGLAPFDCWLLLRG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 259 LKTLHVRMEKHFKNGMAVAQFLESNPGVEKVIYPGLPSHPQHELAKRQCTGCTGMITFyIKGTLQHAEIFLKNLKLFTLA 338
Cdd:TIGR01329 239 IKTLAIRIEKQQENARAIAMFLSTHPRVKKVRYAGLPSHPGFHLHFSQAKGAGSVLSF-ETGSVALSKRLVEATKLFSIT 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 1059158380 339 ESLGGFESLAELPAIMTHASVPKNDRDVLGISDTLIRLSVGLEDEKDLLEDLDQALKAA 397
Cdd:TIGR01329 318 VSFGSVNSLISMPCFMSHASIPAEVREERGLPEDLVRLSVGIEDVDDLISDLDIAFVTA 376
|
|
| O_succ_thio_ly |
TIGR02080 |
O-succinylhomoserine (thiol)-lyase; This family consists of O-succinylhomoserine (thiol)-lyase, ... |
36-397 |
8.02e-129 |
|
O-succinylhomoserine (thiol)-lyase; This family consists of O-succinylhomoserine (thiol)-lyase, one of three different enzymes designated cystathionine gamma-synthase and involved in methionine biosynthesis. In all three cases, sulfur is added by transsulfuration from Cys to yield cystathionine rather than by a sulfhydrylation step that uses H2S directly and bypasses cystathionine. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 131135 Cd Length: 382 Bit Score: 377.60 E-value: 8.02e-129
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 36 AVVPLISLSTTFKQEAPGQHSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAFASGLAA-TVTITHLLKAGDQIICVDDVY 114
Cdd:TIGR02080 21 CVVPPIYLSTTYNFTGFNEPRAYDYSRSGNPTRDLLQQALAELEGGAGAVVTNTGMSAiHLVTTALLGPDDLLVAPHDCY 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 115 GGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPILKMIDIEACAHIVHKHGdIILVVDNTFMSPY 194
Cdd:TIGR02080 101 GGTYRLLNALAKKGCFRVLFVDQGDEQALRAALAQKPKLVLIETPSNPLLRVVDIAKICHLAKAVG-AVVVVDNTFLSPA 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 195 FQRPLALGADICMCSATKYMNGHSDVVMGLVSVNCERLHNRLRFLQNSLGAVPSPLDCYLCNRGLKTLHVRMEKHFKNGM 274
Cdd:TIGR02080 180 LQNPLALGADLVLHSCTKYLNGHSDVIAGAVIAKDPQVAEELAWWANNLGVTGGAFDSYLTLRGLRTLVARMRLQQRNAQ 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 275 AVAQFLESNPGVEKVIYPGLPSHPQHELAKRQCTGCTGMITFYIKGTLQHAEIFLKNLKLFTLAESLGGFESLAELPAIM 354
Cdd:TIGR02080 260 AIVEYLQTQPLVKKIYYPGLPDHPGHEIAARQQKGFGAMLSFELKGGEQTVRRFLGGLSLFTLAESLGGVESLIAHPATM 339
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 1059158380 355 THASVPKNDRDVLGISDTLIRLSVGLEDEKDLLEDLDQALKAA 397
Cdd:TIGR02080 340 THAAMGPEARAEAGISDTLLRLSVGLEDADDLIADLEQGLRAA 382
|
|
| MET17 |
COG2873 |
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid ... |
13-398 |
1.16e-127 |
|
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid transport and metabolism]; O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent is part of the Pathway/BioSystem: Methionine biosynthesis
Pssm-ID: 442120 [Multi-domain] Cd Length: 428 Bit Score: 375.91 E-value: 1.16e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 13 PHFQHFATQAIHVGQEPEQWT-SRAVvPlISLSTTFK----QEAP----GQHSGFEYSRSGNPTRNCLEKAVAALDGAKY 83
Cdd:COG2873 3 EKKYGFETLALHAGQEPDPTTgARAV-P-IYQTTSYVfddaEHAAdlfaLKEPGNIYTRIMNPTTDVLEKRIAALEGGVA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 84 CLAFASGLAA-TVTITHLLKAGDQIICVDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNP 162
Cdd:COG2873 81 ALATASGQAAiTLAILNLAEAGDHIVASSSLYGGTYNLFAHTLPRLGIEVRFVDPDDPEAFEAAIDPNTKAIFGETIGNP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 163 ILKMIDIEACAHIVHKHGdIILVVDNTFMSPYFQRPLALGADICMCSATKYMNGHSDVVMGLV--------SVN------ 228
Cdd:COG2873 161 ALDVLDIEAIAEIAHEHG-VPLIVDNTFATPYLCRPIEHGADIVVHSATKYIGGHGTSIGGVIvdggnfdwAANgkfpel 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 229 ------------CERLHN-------RLRFLQNsLGAVPSPLDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPGVEKV 289
Cdd:COG2873 240 tepdpsyhglvyTEAFGNaafitkaRVQLLRD-LGAALSPFNAFLLLQGLETLSLRMERHVENALKVAEFLEAHPKVAWV 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 290 IYPGLPSHPQHELAKRQCT-GCTGMITFYIKGTLQHAEIFLKNLKLFTLAESLGGFESLAELPAIMTHASVPKNDRDVLG 368
Cdd:COG2873 319 NYPGLPSHPYHELAQKYLPkGAGGVLTFGLKGGREAGKKFIDSLKLFSHLANIGDAKSLVIHPASTTHSQLSEEEQAAAG 398
|
410 420 430
....*....|....*....|....*....|
gi 1059158380 369 ISDTLIRLSVGLEDEKDLLEDLDQALKAAA 398
Cdd:COG2873 399 VTPDLIRLSVGIEDIDDIIADLDQALAAAT 428
|
|
| PRK08064 |
PRK08064 |
cystathionine beta-lyase MetC; |
18-399 |
3.72e-126 |
|
cystathionine beta-lyase MetC;
Pssm-ID: 236146 [Multi-domain] Cd Length: 390 Bit Score: 371.03 E-value: 3.72e-126
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 18 FATQAIHVGQEPEQWTSRAVVPlISLSTTFKQEAPGQHSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAFASGLAATVTI 97
Cdd:PRK08064 7 IDTLLLHNQYKHDKQTGAVNVP-IYHASTFHQFDFDTFGKYDYSRSGNPTREALEDIIAELEGGTKGFAFASGMAAISTA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 98 THLLKAGDQIICVDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPILKMIDIEACAHIVH 177
Cdd:PRK08064 86 FLLLSKGDHVLISEDVYGGTYRMITEVLSRFGIEHTFVDMTNLEEVAQNIKPNTKLFYVETPSNPLLKVTDIRGVVKLAK 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 178 KHGdIILVVDNTFMSPYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVNCERLHNRLRFLQNSLGAVPSPLDCYLCNR 257
Cdd:PRK08064 166 AIG-CLTFVDNTFLTPLLQKPLDLGADVVLHSATKFLAGHSDVLAGLAVVKDEELAQKLYFLQNSFGAVLGVQDCWLVLR 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 258 GLKTLHVRMEKHFKNGMAVAQFLESNPGVEKVIYPGLPSHPQHELAKRQCTGCTGMITFyikgTLQHAEI---FLKNLKL 334
Cdd:PRK08064 245 GLKTLHVRLEHSSETANKIALYLQEHPKVQNVYYPGLQTHLGFDIQQSQATSAGAVLSF----TLQSEEAvrqFVSHVKL 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1059158380 335 FTLAESLGGFESLAELPAIMTHASVPKNDRDVLGISDTLIRLSVGLEDEKDLLEDLDQALKAAAE 399
Cdd:PRK08064 321 PVFAVSLGAVESILSYPAKMSHAAMPKEERDERGITDGLLRLSVGLENVDDLIADFEQALSYVEE 385
|
|
| PRK06234 |
PRK06234 |
methionine gamma-lyase; Provisional |
18-394 |
2.16e-125 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 168478 [Multi-domain] Cd Length: 400 Bit Score: 369.54 E-value: 2.16e-125
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 18 FATQAIHVGQEPEQWTSRAVVPLISLSTTFKQEA-------PGQHSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAFASG 90
Cdd:PRK06234 9 FATKAIHGGHIGDKQFGSLATPIYQTSTFIFDSAeqggrrfAGEESGYIYSRLGNPTSTEVENKLALLEGGEAAVVAASG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 91 LAA-TVTITHLLKAGDQIICVDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPILKMIDI 169
Cdd:PRK06234 89 MGAiSSSLWSALKAGDHVVASDTLYGCTFALLNHGLTRYGVEVTFVDTSNLEEVRNALKANTKVVYLETPANPTLKVTDI 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 170 EACAHIVHKHG-DIILVVDNTFMSPYFQRPLALGADICMCSATKYMNGHSDVVMGLVsVNCERLHNRLRF--LQNSLGAV 246
Cdd:PRK06234 169 KAISNIAHENNkECLVFVDNTFCTPYIQRPLQLGADVVVHSATKYLNGHGDVIAGFV-VGKEEFINQVKLfgIKDMTGSV 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 247 PSPLDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPGVEKVIYPGLPSHPQHELAKRQCTGCTGMITFYIKGTLQHAE 326
Cdd:PRK06234 248 IGPFEAFLIIRGMKTLQIRMEKHCKNAMKVAKFLESHPAVEKVYYPGLESFEYYELAKKQMSLPGAMISFELKGGVEEGK 327
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1059158380 327 IFLKNLKLFTLAESLGGFESLAELPAIMTHASVPKNDRDVLGISDTLIRLSVGLEDEKDLLEDLDQAL 394
Cdd:PRK06234 328 VVMNNVKLATLAVSLGDAETLIQHPASMTHSPYTAEERKEAGISDGLVRLSVGLEDVDDIIADLKQAL 395
|
|
| PRK08247 |
PRK08247 |
methionine biosynthesis PLP-dependent protein; |
16-397 |
2.18e-125 |
|
methionine biosynthesis PLP-dependent protein;
Pssm-ID: 181320 [Multi-domain] Cd Length: 366 Bit Score: 367.88 E-value: 2.18e-125
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 16 QHFATQAIHVGQEPEQWTSrAVVPLISLSTTFKQEAPGQHSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAFASGLAATV 95
Cdd:PRK08247 3 STIETKLAQIGNRSDERTG-TVNPPVYFSTAYRHEGIGESTGFDYSRTGNPTRGVLEQAIADLEGGDQGFACSSGMAAIQ 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 96 TITHLLKAGDQIICVDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPILKMIDIEACAHI 175
Cdd:PRK08247 82 LVMSLFRSGDELIVSSDLYGGTYRLFEEHWKKWNVRFVYVNTASLKAIEQAITPNTKAIFIETPTNPLMQETDIAAIAKI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 176 VHKHGdIILVVDNTFMSPYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVNCERLHNRLRFLQNSLGAVPSPLDCYLC 255
Cdd:PRK08247 162 AKKHG-LLLIVDNTFYTPVLQRPLEEGADIVIHSATKYLGGHNDVLAGLVVAKGQELCERLAYYQNAAGAVLSPFDSWLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 256 NRGLKTLHVRMEKHFKNGMAVAQFLESNPGVEKVIYPGLpshpqhelakrqctgcTGMITFyikgTLQHAE---IFLKNL 332
Cdd:PRK08247 241 IRGMKTLALRMRQHEENAKAIAAFLNEQPGVTDVLYPGR----------------GGMLSF----RLQDEEwvnPFLKSL 300
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1059158380 333 KLFTLAESLGGFESLAELPAIMTHASVPKNDRDVLGISDTLIRLSVGLEDEKDLLEDLDQALKAA 397
Cdd:PRK08247 301 KLITFAESLGGVESFITYPATQTHADIPEEIRIANGVCNRLLRFSVGIENVEDLIADLKQAFKQV 365
|
|
| met_gam_lyase |
TIGR01328 |
methionine gamma-lyase; This model describes a methionine gamma-lyase subset of a family of ... |
16-396 |
1.85e-124 |
|
methionine gamma-lyase; This model describes a methionine gamma-lyase subset of a family of PLP-dependent trans-sulfuration enzymes. The member from the parasite Trichomonas vaginalis is described as catalyzing alpha gamma- and alpha-beta eliminations and gamma-replacement reactions on methionine, cysteine, and some derivatives. Likewise, the enzyme from Pseudomonas degrades cysteine as well as methionine. [Energy metabolism, Amino acids and amines]
Pssm-ID: 130395 [Multi-domain] Cd Length: 391 Bit Score: 366.52 E-value: 1.85e-124
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 16 QHFATQAIHVGQEPEQWTSrAVVPLISLSTTFKQEA--------PGQHSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAF 87
Cdd:TIGR01328 2 MTFATRAIHAGYPPKDQFG-ALTPPIYQTSTFVFDSceqggnrfAGQESGYIYSRLGNPTVSNLEGRIAFLEGTEAAVAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 88 ASGLAA-TVTITHLLKAGDQIICVDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPILKM 166
Cdd:TIGR01328 81 SSGMGAiAATLLTILKAGDHLISDECLYGCTFALLEHALTKFGIQVDFINMAIPEEVKAHIKDNTKIVYFETPANPTMKL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 167 IDIEACAHIVHKHGdIILVVDNTFMSPYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVNCERLHN-RLRFLQNSLGA 245
Cdd:TIGR01328 161 IDMERVCRDAHSQG-VKVIVDNTFATPMLTNPVALGVDVVVHSATKYIGGHGDVVAGLICGKAELLQQiRMVGIKDMTGS 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 246 VPSPLDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPGVEKVIYPGLPSHPQHELAKRQCTGCTGMITFYIKGTLQHA 325
Cdd:TIGR01328 240 VISPFDAWLILRGLKTLNIRMKRHSENAMKVAEYLKSHPAVEKVYYPGFEDHPGHDIAAKQMRMGGGMITFELKGGFAGA 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1059158380 326 EIFLKNLKLFTLAESLGGFESLAELPAIMTHASVPKNDRDVLGISDTLIRLSVGLEDEKDLLEDLDQALKA 396
Cdd:TIGR01328 320 KKLLNNLKLIRLAVSLGDAETLIQHPASMTHAVVPKEEREAAGITDGMIRLSVGLEDADDLIADLKQALDA 390
|
|
| PRK07503 |
PRK07503 |
methionine gamma-lyase; Provisional |
18-402 |
2.74e-121 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 181005 [Multi-domain] Cd Length: 403 Bit Score: 359.12 E-value: 2.74e-121
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 18 FATQAIHVGQEPEQwTSRAVVPLISLSTTFKQEA--------PGQHSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAFAS 89
Cdd:PRK07503 10 FSTRAIHHGYDPLD-HGGALVPPVYLTATFAFPTaeygaecfAGEEEGHFYSRISNPTLALLEQRMASLEGGEAAVALAS 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 90 GLAA-TVTITHLLKAGDQIICVDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPILKMID 168
Cdd:PRK07503 89 GMGAiTATLWTLLRPGDEVIVDQTLYGCTFAFLHHGLGEFGVTVRHVDLTDPAALKAAISDKTRMVYFETPANPNMRLVD 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 169 IEACAHIVHKHGdIILVVDNTFMSPYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVNCERLHN-RLRFLQNSLGAVP 247
Cdd:PRK07503 169 IAAVAEIAHGAG-AKVVVDNTYCTPYLQRPLELGADLVVHSATKYLGGHGDITAGLVVGGKALADRiRLEGLKDMTGAVM 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 248 SPLDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPGVEKVIYPGLPSHPQHELAKRQCTGCTGMITFYIKGTLQHAEI 327
Cdd:PRK07503 248 SPFDAFLLMRGLKTLALRMDRHCASAQAVAEWLARHPAVELVHYPGLPSFAQHALAQRQMALPGGMIAFELKGGIAAGRR 327
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1059158380 328 FLKNLKLFTLAESLGGFESLAELPAIMTHASVPKNDRDVLGISDTLIRLSVGLEDEKDLLEDLDQALKAAAESGS 402
Cdd:PRK07503 328 FMNALQLFARAVSLGDAESLAQHPASMTHSTYTPEERAEHGISEGLVRLSVGLEDVADILADLAQALDACAVAAA 402
|
|
| PLN02509 |
PLN02509 |
cystathionine beta-lyase |
36-395 |
6.30e-120 |
|
cystathionine beta-lyase
Pssm-ID: 178125 [Multi-domain] Cd Length: 464 Bit Score: 357.80 E-value: 6.30e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 36 AVVPLISLSTTFKQEAPGQHSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAFASGLAATVTITHLLKAGDQIICVDDVYG 115
Cdd:PLN02509 103 AMSTPLYQTATFKQPSAIENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALSAVTHLIKNGEEIVAGDDVYG 182
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 116 GTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPILKMIDIEACAHIVHKHGDIILVvDNTFMSPYF 195
Cdd:PLN02509 183 GSDRLLSQVVPRSGVVVKRVNTTNLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKIAEMAHAQGALVLV-DNSIMSPVL 261
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 196 QRPLALGADICMCSATKYMNGHSDVVMGLVSVNCERLHNRLRFLQNSLGAVPSPLDCYLCNRGLKTLHVRMEKHFKNGMA 275
Cdd:PLN02509 262 SRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWLCLRGIKTMALRIEKQQENARK 341
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 276 VAQFLESNPGVEKVIYPGLPSHPQHELAKRQCTGCTGMITFyIKGTLQHAEIFLKNLKLFTLAESLGGFESLAELPAIMT 355
Cdd:PLN02509 342 IAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAKGAGSVFSF-ITGSVALSKHLVETTKYFSIAVSFGSVKSLISMPCFMS 420
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 1059158380 356 HASVPKNDRDVLGISDTLIRLSVGLEDEKDLLEDLDQALK 395
Cdd:PLN02509 421 HASIPAEVREARGLTEDLVRISAGIEDVDDLISDLDIAFR 460
|
|
| PRK06767 |
PRK06767 |
methionine gamma-lyase; Provisional |
16-395 |
3.83e-115 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 180685 [Multi-domain] Cd Length: 386 Bit Score: 342.59 E-value: 3.83e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 16 QHFATQAIHVGQEPEQWTSRAVVPLISLST-TF---KQEA---PGQHSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAFA 88
Cdd:PRK06767 4 KHMETALIHHGYTSEEHKGSLTPPLFQTSTfTFetaQQGEasfAGVDPSYIYSRLGNPTVKLFEERMAVLEGGEEALAFG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 89 SGLAA-TVTITHLLKAGDQIICVDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPILKMI 167
Cdd:PRK06767 84 SGMAAiSATLIGFLKAGDHIICSNGLYGCTYGFLEVLEEKFMITHSFCDMETEADIENKIRPNTKLIFVETPINPTMKLI 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 168 DIEACAHIVHKHGdIILVVDNTFMSPYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVNCERLHNRLRFLQNSLGAVP 247
Cdd:PRK06767 164 DLKQVIRVAKRNG-LLVIVDNTFCSPYLQRPLELGCDAVVHSATKYIGGHGDVVAGVTICKTRALAEKIRPMRKDIGGIM 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 248 SPLDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPGVEKVIYpglpshPQHELAKRQCTGCTGMITFYIKGTLQHAEI 327
Cdd:PRK06767 243 APFDAWLLLRGLKTLAVRMDRHCDNAEKIVSFLKNHDAVEGVWY------PEGELASRQMKRGGGVISFSIKGGKEETQA 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1059158380 328 FLKNLKLFTLAESLGGFESLAELPAIMTHASVPKNDRDVLGISDTLIRLSVGLEDEKDLLEDLDQALK 395
Cdd:PRK06767 317 FINDLHFITIAVSLGDTETLIQHPATMTHAAIPAELRQEMGIYDNLIRLSVGLESWEDIVSDLEQALK 384
|
|
| PRK08133 |
PRK08133 |
O-succinylhomoserine sulfhydrylase; Validated |
17-396 |
3.98e-109 |
|
O-succinylhomoserine sulfhydrylase; Validated
Pssm-ID: 181244 [Multi-domain] Cd Length: 390 Bit Score: 327.34 E-value: 3.98e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 17 HFATQAIHVGQE--PEQWTSRAVVPliSLSTTFKQEA------PGQHSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAFA 88
Cdd:PRK08133 6 GFDTLAVRAGQLrsPFGEHSEALFL--TSSFVFESAAeaaarfAGEEPGNIYSRFTNPTVTMFQERLAALEGAEACVATA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 89 SGLAATVTIT-HLLKAGDQIICVDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPILKMI 167
Cdd:PRK08133 84 SGMAAILAVVmALLQAGDHVVSSRSLFGSTVSLFEKIFARFGIETTFVDLTDLDAWRAAVRPNTKLFFLETPSNPLTELA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 168 DIEACAHIVHKHGdIILVVDNTFMSPYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVNCERLHNRLRFLQnSLGAVP 247
Cdd:PRK08133 164 DIAALAEIAHAAG-ALLVVDNCFCTPALQQPLKLGADVVIHSATKYLDGQGRVLGGAVVGSKELMEEVFGFLR-TAGPTL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 248 SPLDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPGVEKVIYPGLPSHPQHELAKRQCTGCTGMITFYIKGTLQHAEI 327
Cdd:PRK08133 242 SPFNAWVFLKGLETLSLRMEAHSANALALAEWLEAHPGVERVFYPGLPSHPQHELAKRQQKGGGAIVSFEVKGGREAAWR 321
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1059158380 328 FLKNLKLFTLAESLGGFESLAELPAIMTHASVPKNDRDVLGISDTLIRLSVGLEDEKDLLEDLDQALKA 396
Cdd:PRK08133 322 VIDATRLISITANLGDTKTTITHPATTTHGRLSPEARAAAGITEGLIRVAVGLEDVADIKADLARGLAA 390
|
|
| PRK08861 |
PRK08861 |
O-succinylhomoserine (thiol)-lyase; |
19-400 |
7.17e-109 |
|
O-succinylhomoserine (thiol)-lyase;
Pssm-ID: 181567 [Multi-domain] Cd Length: 388 Bit Score: 326.85 E-value: 7.17e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 19 ATQAIHVGQEPEQwTSRAVVPLISLSTTFKQEAPGQHSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAFASGLAA-TVTI 97
Cdd:PRK08861 7 ATIAVRTGIESDS-QYHAVVPPIYLSTNYGFPAFGEVPKYDYTRSGNPNRGLLEQTLSELESGKGAVVTNCGTSAlNLWV 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 98 THLLKAGDQIICVDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPILKMIDIEACAHIVH 177
Cdd:PRK08861 86 SALLGPDDLIVAPHDCYGGTYRLFNTRANKGDFKVQFVDQSDAAALDAALAKKPKLILLETPSNPLVRVVDIAELCQKAK 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 178 KHGDIIlVVDNTFMSPYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVNCERLHNRLRFLQNSLGAVPSPLDCYLCNR 257
Cdd:PRK08861 166 AVGALV-AVDNTFLTPVLQKPLELGADFVIHSTTKYINGHSDVIGGVLITKTKEHAEELAWWGNCIGATGTPFDSYMTLR 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 258 GLKTLHVRMEKHFKNGMAVAQFLESNPGVEKVIYPGLPSHPQHELAKRQCTGCTGMITFYIKGTLQHAEIFLKNLKLFTL 337
Cdd:PRK08861 245 GIRTLGARMRVHEESAQQILAYLQTQSLVGTIYHPSLPEHPGHEIAKKQQSGFGSMLSFEFAGSFEQLKVFVKALALFSL 324
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1059158380 338 AESLGGFESLAELPAIMTHASVPKNDRDVLGISDTLIRLSVGLEDEKDLLEDLDQALKAAAES 400
Cdd:PRK08861 325 AESLGGVESLICHPASMTHRAMGEEALAEAGVSQQLLRLSVGLEDAQDLIADLDQAFAKAAEA 387
|
|
| PRK07269 |
PRK07269 |
cystathionine gamma-synthase; Reviewed |
17-396 |
1.10e-107 |
|
cystathionine gamma-synthase; Reviewed
Pssm-ID: 235983 Cd Length: 364 Bit Score: 322.93 E-value: 1.10e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 17 HFATQAIHVGQEPEQWTSRAVVPlISLSTTFKQEAPGQHSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAFASGLAATVT 96
Cdd:PRK07269 6 HINTILAQAGIKSDEATGALVTP-LHFSTTYQHPEFGQSTGFDYTRTKNPTRAKLEETLAAIESADYALATSSGMSAIVL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 97 ITHLLKAGDQIICVDDVYGGTNRYFRQVASEFglKISFVDCSKIKLLEAAITPETKLVWIETPTNPILKMIDIEACAHIV 176
Cdd:PRK07269 85 AFSVFPVGSKVVAVRDLYGGSFRWFNQQEKEG--RFHFTYANTEEELIAAIEEDTDIVYIETPTNPLMVEFDIEKVAKLA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 177 HKHGdIILVVDNTFMSPYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVNCERLHNRLRFLQNSLGAVPSPLDCYLCN 256
Cdd:PRK07269 163 HAKG-AKVIVDNTFYSPIYQRPIELGADIVLHSATKYLSGHNDVLAGVVVTNDLELYEKLFYNLNTTGAVLSPFDSYLLM 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 257 RGLKTLHVRMEKHFKNGMAVAQFLESNPGVEKVIYPGLpshpqhelakrqctgcTGMITFYI--KGTLQHaeiFLKNLKL 334
Cdd:PRK07269 242 RGLKTLSLRMERSTANAQEVVAFLKKSPAVKEVLYTGK----------------GGMISFKVadETRIPH---ILNSLKV 302
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1059158380 335 FTLAESLGGFESLAELPAIMTHASVPKNDRDVLGISDTLIRLSVGLEDEKDLLEDLDQALKA 396
Cdd:PRK07269 303 FTFAESLGGVESLITYPTTQTHADIPAEVRHSYGLTDDLLRLSIGIEDARDLIADLKQALEG 364
|
|
| PRK08574 |
PRK08574 |
cystathionine gamma-synthase family protein; |
19-396 |
2.82e-107 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 236298 [Multi-domain] Cd Length: 385 Bit Score: 322.40 E-value: 2.82e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 19 ATQAIHVGQEPEQWtsRAVVPLISLSTTFKQEAPGQHS--GFE--YSRSGNPTRNCLEKAVAALDGAKYCLAFASGLAAT 94
Cdd:PRK08574 4 GTDAVRGYRGSDPY--GSLQPPIYLTALFRQEGEAYPSdrGFDlkYSREENPTLRPLEEALAKLEGGVDALAFNSGMAAI 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 95 VTI-THLLKAGDQIICVDDVYGGTNRYFRQVaSEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPILKMIDIEACA 173
Cdd:PRK08574 82 STLfFSLLKAGDRVVLPMEAYGTTLRLLKSL-EKFGVKVVLAYPSTEDIIEAIKEGRTKLVFIETMTNPTLKVIDVPEVA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 174 HiVHKHGDIILVVDNTFMSPYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVNCERLHNRLRFLQNSLGAVPSPLDCY 253
Cdd:PRK08574 161 K-AAKELGAILVVDNTFATPLLYRPLRHGADFVVHSLTKYIAGHNDVVGGVAVAWSGEFLEELWEWRRRLGTIMQPFEAY 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 254 LCNRGLKTLHVRMEKHFKNGMAVAQFLESNPGVEKVIYPGLPSHPQHELAKR--QCTGCTGMITFYIKGTLQHAEIFLKN 331
Cdd:PRK08574 240 LVLRGLKTLEVRFERQCRNAMAIAEFLSEHPKVAEVYYPGLPSDPYHGVAKRlfGKDLYGGVVSFRVKGGRDAVLKFLRS 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1059158380 332 LKLFTLAESLGGFESLAELPAIMTHASVPKNDRDVLGISDTLIRLSVGLEDEKDLLEDLDQALKA 396
Cdd:PRK08574 320 LKLIKPSPSLGGVESLATYPVKSAASPIPEEDRKALGITEDLVRLSVGLEDVEDLIEDLDQALGS 384
|
|
| PRK08776 |
PRK08776 |
O-succinylhomoserine (thiol)-lyase; |
17-397 |
2.91e-107 |
|
O-succinylhomoserine (thiol)-lyase;
Pssm-ID: 181554 [Multi-domain] Cd Length: 405 Bit Score: 323.09 E-value: 2.91e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 17 HFATQAIHVGQEPEQwTSRAVVPLISLSTTFKQEAPGQHSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAFASGLAATVT 96
Cdd:PRK08776 12 SAATAAVRAGIDRDT-AYGAVTPPIVLSSNFSFDGFGNKRQYDYTRSGNPTRDLLGEALAELEGGAGGVITATGMGAINL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 97 ITH-LLKAGDQIICVDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPILKMIDIEACAHI 175
Cdd:PRK08776 91 VLNaLLQPGDTLVVPHDAYGGSWRLFNALAKKGHFALITADLTDPRSLADALAQSPKLVLIETPSNPLLRITDLRFVIEA 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 176 VHKHGDIIlVVDNTFMSPYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVNCERLHNRLRFLQNSLGAVPSPLDCYLC 255
Cdd:PRK08776 171 AHKVGALT-VVDNTFLSPALQKPLEFGADLVLHSTTKYINGHSDVVGGAVVARDAELHQQLVWWANALGLTGSPFDAFLT 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 256 NRGLKTLHVRMEKHFKNGMAVAQFLESNPGVEKVIYPGLPSHPQHELAKRQCTGCTGMITFYIKGTLQHAEIFLKNLKLF 335
Cdd:PRK08776 250 LRGLRTLDARLRVHQENADAIAALLDGHAAVNQVYYPGLASHPGHALAARQQKGFGAMLSFELEGGEAAVRAFVDGLRYF 329
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1059158380 336 TLAESLGGFESLAELPAIMTHASVPKNDRDVLGISDTLIRLSVGLEDEKDLLEDLDQALKAA 397
Cdd:PRK08776 330 TLAESLGGVESLIAHPASMTHAAMTAEARAAAGISDGLLRLSVGIESAEDLLIDLRAGLARA 391
|
|
| PRK08249 |
PRK08249 |
cystathionine gamma-synthase family protein; |
17-400 |
3.04e-106 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 236202 [Multi-domain] Cd Length: 398 Bit Score: 320.53 E-value: 3.04e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 17 HFATQAIHVGqEPEQWTSRAVVPLISLSTTFKQE--------APGQHSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAFA 88
Cdd:PRK08249 8 GVGTKAVWAG-EKEYLPYGATQVPVVLSVAYGYDdidewydvALGKKPGHIYSRNTNPTVQAFEEKVRILEGAEAATAFS 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 89 SGLAA-TVTITHLLKAGDQIICVDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPILKMI 167
Cdd:PRK08249 87 TGMAAiSNTLYTFLKPGDRVVSIKDTYGGTNKIFTEFLPRMGVDVTLCETGDHEQIEAEIAKGCDLLYLETPTNPTLKIV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 168 DIEACAHIVHKHGDIIlVVDNTFMSPYFQRPLALGADICMCSATKYMNGHSDVvMGLVSVNCERLHNRLRFLQNSLGAVP 247
Cdd:PRK08249 167 DIERLAAAAKKVGALV-VVDNTFATPINQNPLALGADLVIHSATKFLSGHADA-LGGVVCGSKELMEQVYHYREINGATM 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 248 SPLDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPGVEKVIYPGLPSHPQHELAKRQCTGCTGMITFYIKGTLQHAEI 327
Cdd:PRK08249 245 DPMSAYLILRGMKTLKLRVRQQQESAMALAKYLQTHPKVEAVYYPGLETHPNHEIAKAQMRGFGGILSFVLKGGMDTVKR 324
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1059158380 328 FLKNLKLFTLAESLGGFESLAELPAIMTHASVPKNDRDVLGISDTLIRLSVGLEDEKDLLEDLDQALKAAAES 400
Cdd:PRK08249 325 LLPKLRYAHRAANLGAVETIYGPARTTSHVENTLEERAALGIPEGLVRISVGIEDTEDLIADLEQAFAHLESE 397
|
|
| OAH_OAS_sulfhy |
TIGR01326 |
OAH/OAS sulfhydrylase; This model describes a distinct clade of the Cys/Met metabolism ... |
17-395 |
3.46e-104 |
|
OAH/OAS sulfhydrylase; This model describes a distinct clade of the Cys/Met metabolism pyridoxal phosphate-dependent enzyme superfamily. Members include examples of OAH/OAS sulfhydrylase, an enzyme with activity both as O-acetylhomoserine (OAH) sulfhydrylase (EC 2.5.1.49) and O-acetylserine (OAS) sulphydrylase (EC 2.5.1.47). An alternate name for OAH sulfhydrylase is homocysteine synthase. This model is designated subfamily because it may or may not have both activities. [Amino acid biosynthesis, Aspartate family, Amino acid biosynthesis, Serine family]
Pssm-ID: 273555 [Multi-domain] Cd Length: 418 Bit Score: 315.84 E-value: 3.46e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 17 HFATQAIHVGQEPEQWTSRAVVPlISLSTTFKQEAPG--------QHSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAFA 88
Cdd:TIGR01326 1 HFETLQLHAGQEPDPTTGSRAVP-IYQTTSYVFDSTEhaaalfglQEPGNIYSRLMNPTTDVLEQRIAALEGGVAALAVA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 89 SGLAA-TVTITHLLKAGDQIICVDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPILKMI 167
Cdd:TIGR01326 80 SGQAAiTYAILNLAGAGDNIVSSSYLYGGTYNLFSHTLKRLGIEVRFVDPDDPESLEKAIDENTKAVFAETIGNPQINVL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 168 DIEACAHIVHKHGdIILVVDNTFMSPYFQRPLALGADICMCSATKYMNGHSDVVMGLV------SVNCER---------- 231
Cdd:TIGR01326 160 DIEAIAEVAHRHG-IPLIVDNTFATPYLCRPIKHGADIVVHSATKYIGGHGTAIGGVIvdggkfDWNNGRfplfttpdps 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 232 ----------------LHNRLRFLQNsLGAVPSPLDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPGVEKVIYPGLP 295
Cdd:TIGR01326 239 yhglvftetlgnpafiLKARVQLLRD-LGAALSPFNAFLLLQGLETLSLRMERHVENALKVAEFLESHPDVAWVNYPGLA 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 296 SHPQHELAKRQCTGCTG-MITFYIKGTLQHAEIFLKNLKLFTLAESLGGFESLAELPAIMTHASVPKNDRDVLGISDTLI 374
Cdd:TIGR01326 318 SHPHHALAKKYLPKGFGaVLSFEIKGGREAGKKFIDALKLASHLANVGDAKSLVIHPASTTHSQLSEEEQLKAGVTPGLI 397
|
410 420
....*....|....*....|.
gi 1059158380 375 RLSVGLEDEKDLLEDLDQALK 395
Cdd:TIGR01326 398 RLSVGIENIDDIIADLEQALE 418
|
|
| PRK08045 |
PRK08045 |
cystathionine gamma-synthase; Provisional |
19-399 |
5.25e-104 |
|
cystathionine gamma-synthase; Provisional
Pssm-ID: 169194 [Multi-domain] Cd Length: 386 Bit Score: 314.14 E-value: 5.25e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 19 ATQAIHVG-QEPEQWTsrAVVPLISLSTTFKQEAPGQHSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAFASGLAAT-VT 96
Cdd:PRK08045 6 ATIAVRSGlNDDEQYG--CVVPPIHLSSTYNFTGFNEPRAHDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAIhLV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 97 ITHLLKAGDQIICVDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPILKMIDIEACAHIV 176
Cdd:PRK08045 84 TTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQGDEQALRAALAEKPKLVLVESPSNPLLRVVDIAKICHLA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 177 HKHGDIIlVVDNTFMSPYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVNCERLHNRLRFLQNSLGAVPSPLDCYLCN 256
Cdd:PRK08045 164 REAGAVS-VVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDPDVVTELAWWANNIGVTGGAFDSYLLL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 257 RGLKTLHVRMEKHFKNGMAVAQFLESNPGVEKVIYPGLPSHPQHELAKRQCTGCTGMITFYIKGTLQHAEIFLKNLKLFT 336
Cdd:PRK08045 243 RGLRTLVPRMELAQRNAQAIVKYLQTQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFELDGDEQTLRRFLGGLSLFT 322
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1059158380 337 LAESLGGFESLAELPAIMTHASVPKNDRDVLGISDTLIRLSVGLEDEKDLLEDLDQALKAAAE 399
Cdd:PRK08045 323 LAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLENGFRAANK 385
|
|
| PRK06434 |
PRK06434 |
cystathionine gamma-lyase; Validated |
15-396 |
1.42e-101 |
|
cystathionine gamma-lyase; Validated
Pssm-ID: 102374 [Multi-domain] Cd Length: 384 Bit Score: 307.98 E-value: 1.42e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 15 FQHFATQAIHVGQEPEQWTSRAVVPLISLSTTF----KQEAPGQHSG---FEYSRSGNPTRNCLEKAVAALDGAKYCLAF 87
Cdd:PRK06434 6 LNGFNTRAVQSGELRDPRFGNVTTPIFETSTFVypnsEKEAYMDSTRgmpYIYTRWGNPTVQAFEEKYAVLENAEHALSF 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 88 ASGLAA-TVTITHLLKAGDQIICVDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITpETKLVWIETPTNPILKM 166
Cdd:PRK06434 86 SSGMGAiTSAILSLIKKGKRILSISDLYGQTFYFFNKVLKTLGIHVDYIDTDRLNSLDFDPS-NYDLIYAESITNPTLKV 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 167 IDIEACAHIVHKHgdiILVVDNTFMSPYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVNCERLHNRLRFLQNSLGAV 246
Cdd:PRK06434 165 PDIKNVSSFCHEN---DVIVDATFASPYNQNPLDLGADVVIHSATKYISGHSDVVMGVAGTNNKSIFNNLVERRKTLGSN 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 247 PSPLDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPGVEKVIYPGLpshpqhELAKRQCTGCTGMITFYIKgTLQHAE 326
Cdd:PRK06434 242 PDPIQAYLALRGLKTLGLRMEKHNKNGMELARFLRDSKKISNVYYPDT------EIGKKVLRGFGGMLSFELR-SMEDVH 314
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 327 IFLKNLKLFTLAESLGGFESLAELPAIMTHASVPKNDRDVLGISDTLIRLSVGLEDEKDLLEDLDQALKA 396
Cdd:PRK06434 315 KFIRNLEIPMVAASLGGVESLITLPVETSHSSLSPEERERLGISDNLVRFSIGIEDIDDLIKDIENALSK 384
|
|
| O_suc_HS_sulf |
TIGR01325 |
O-succinylhomoserine sulfhydrylase; This model describes O-succinylhomoserine sulfhydrylase, ... |
19-394 |
3.10e-101 |
|
O-succinylhomoserine sulfhydrylase; This model describes O-succinylhomoserine sulfhydrylase, one of several related pyridoxal phosphate-dependent enzymes of cysteine and methionine metabolism. This enzyme is part of an alternative pathway of homocysteine biosynthesis, a step in methionine biosynthesis. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 188131 Cd Length: 381 Bit Score: 306.77 E-value: 3.10e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 19 ATQAIHVGQEPEQWTSRAVVPLISLSTTFKQEA------PGQHSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAFASGLA 92
Cdd:TIGR01325 1 ATLAVRGGMLRSGFEETAEALYLTSGYVYDSAAvaakrfAGELPGFVYSRYGNPTVSVFEERLALLEGAEAAVATASGMA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 93 ATVT-ITHLLKAGDQIICVDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPILKMIDIEA 171
Cdd:TIGR01325 81 AIFAaLMALLGAGDHVVASRSLFGSCFVVCSEILPRFGVQTVFVDGTDLSAWEAALKPNTKAVFVETPSNPLQELVDIAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 172 CAHIVHKHGdIILVVDNTFMSPYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVNCERLHNRLRFLQNSLGAVPSPLD 251
Cdd:TIGR01325 161 VAELAHAAG-AKVVVDNVFATPLLQQPLKLGADVVVYSATKHIDGQGRVLGGAILGSEEYMDEPVQKLLRHTGPAMSPFN 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 252 CYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPGVEKVIYPGLPSHPQHELAKRQCTGCTGMITFYIKGTlQHAEIFLKN 331
Cdd:TIGR01325 240 AWVLLKGLETLAIRVQHQNASALAIAEWLNGHPSVQWVYYPGLPSHPQHELAKRQMSGGGTVVTFDLDCR-QAAFKVLDA 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1059158380 332 LKLFTLAESLGGFESLAELPAIMTHASVPKNDRDVLGISDTLIRLSVGLEDEKDLLEDLDQAL 394
Cdd:TIGR01325 319 MRLVDISNNLGDAKSTITHPATTTHRRMGPEERAAAGIGDGLVRLSVGLEDVDDLIADIDRAL 381
|
|
| PRK08248 |
PRK08248 |
homocysteine synthase; |
20-397 |
6.81e-93 |
|
homocysteine synthase;
Pssm-ID: 236201 [Multi-domain] Cd Length: 431 Bit Score: 287.12 E-value: 6.81e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 20 TQAIHVGQEPEQWT-SRAVVPLISLSTTFKQEAPG------QHSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAFASGLA 92
Cdd:PRK08248 11 TLAIHAGQEIDPTTgSRAVPIYQTTSYGFRDSEHAanlfslKEFGNIYTRIMNPTTDVFEKRIAALEGGIGALAVSSGQA 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 93 A-TVTITHLLKAGDQIICVDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPILKMIDIEA 171
Cdd:PRK08248 91 AiTYSILNIASAGDEIVSSSSLYGGTYNLFAHTLPKLGITVKFVDPSDPENFEAAITDKTKALFAETIGNPKGDVLDIEA 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 172 CAHIVHKHGdIILVVDNTFMSPYFQRPLALGADICMCSATKYMNGHSDVVMGLVsVNCER-------------------- 231
Cdd:PRK08248 171 VAAIAHEHG-IPLIVDNTFASPYLLRPIEHGADIVVHSATKFIGGHGTSIGGVI-VDSGKfdwkgsgkfpgltepdpsyh 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 232 --------------LHNRLRFLQNsLGAVPSPLDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPGVEKVIYPGLPSH 297
Cdd:PRK08248 249 glvytdavgeaayiTKARVQLLRD-LGAALSPFNSFLLLQGLETLHLRMERHSENALAVAKFLEEHEAVEWVSYPGLPSH 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 298 PQHELAKRQCTGCTGMI-TFYIKGTLQHAEIFLKNLKLFTLAESLGGFESLAELPAIMTHASVPKNDRDVLGISDTLIRL 376
Cdd:PRK08248 328 PSYELAKKYLPKGQGAIlTFGIKGGVEAGKKLIDSVKLFSHLANVGDSKSLIIHPASTTHQQLSEEEQLAAGVTPGLVRL 407
|
410 420
....*....|....*....|.
gi 1059158380 377 SVGLEDEKDLLEDLDQALKAA 397
Cdd:PRK08248 408 SVGTEAIDDILDDLRQAIRQS 428
|
|
| PRK06460 |
PRK06460 |
hypothetical protein; Provisional |
58-394 |
3.77e-92 |
|
hypothetical protein; Provisional
Pssm-ID: 235807 [Multi-domain] Cd Length: 376 Bit Score: 283.65 E-value: 3.77e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 58 FEYSRSGNPTRNCLEKAVAALDGAKYCLAFASGLAA-TVTITHLLKAGDQIICVDDVYGGTNRYFRQVASEFGLKISFVD 136
Cdd:PRK06460 37 YRYSREANPTVLELTKKIVELENAEMGVAFSSGMGAiSTTALALLKPGNSVLVHRDMFGRSYRFFTDYLKNWGVNVDASN 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 137 CSKIKLLEAAITPETKLVWIETPTNPILKMIDIEACAHIVHKHGdIILVVDNTFMSPYFQRPLALGADICMCSATKYMNG 216
Cdd:PRK06460 117 PGSDNIIEKAKSKRYDVVFVENITNPLLRVVDITELSKVCKENG-SILIVDATFSTPINQKPLELGADIVVHSASKFLAG 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 217 HSDVVMGLVSVNCErLHNRLRFLQNSLGAVPSPLDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPGVEKVIYPGLPS 296
Cdd:PRK06460 196 HNDVIAGLAAGYGK-LLNVIDQMRRTLGTSLDPHAAYLTLRGIKTLKIRMDVINRNAEQIAEFLEGHPKVVKVYYPGLKS 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 297 HPQHELAKRQCTGCTGMITFYIKGTLQHAEIFLKNLKLFTLAESLGGFESLAELPAIMTHASVPKNDRDVLGISDTLIRL 376
Cdd:PRK06460 275 HVDYEIARRVLKGFGGVLSFEVNGGQESALKVMKSLKLIIPAQTLGGVNSVISHPATMSHRTLSLEERKIVGITDSLLRL 354
|
330
....*....|....*...
gi 1059158380 377 SVGLEDEKDLLEDLDQAL 394
Cdd:PRK06460 355 SVGIEDVNDLIEDLDRAL 372
|
|
| PRK08134 |
PRK08134 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
18-402 |
3.09e-90 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 236159 Cd Length: 433 Bit Score: 280.47 E-value: 3.09e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 18 FATQAIHVGQEPEQWTSRAVVPlISLSTT------------FKQEAPGQhsgfEYSRSGNPTRNCLEKAVAALDGAKYCL 85
Cdd:PRK08134 9 FDTLALHAGAAPDPATGARAVP-IHLTTSfvfrdsdhaaalFNLERAGH----VYSRISNPTVAVLEERVAALEGGVGAI 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 86 AFASGLAA-TVTITHLLKAGDQIICVDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPIL 164
Cdd:PRK08134 84 ATASGQAAlHLAIATLMGAGSHIVASSALYGGSHNLLHYTLRRFGIETTFVKPGDIDGWRAAIRPNTRLLFGETLGNPGL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 165 KMIDIEACAHIVHKHGdIILVVDNTFMSPYFQRPLALGADICMCSATKYMNGHSDVVMGLV------------------- 225
Cdd:PRK08134 164 EVLDIPTVAAIAHEAG-VPLLVDSTFTTPYLLRPFEHGADLVYHSATKFLGGHGTAIGGVLvdggrfdweasgkfpelte 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 226 --------------SVNCERLHNRLRFLQNsLGAVPSPLDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPGVEKVIY 291
Cdd:PRK08134 243 pyagfhgmvfaeesTVAAFLLRARREGLRD-FGACLSPMNAWQLLQGIETLPLRMERHVANTRKVVAFLASHPAVARVAH 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 292 PGLPSHPQHELAKRQC-TGCTGMITFYIKGTLQHAEIFLKNLKLFTLAESLGGFESLAELPAIMTHASVPKNDRDVLGIS 370
Cdd:PRK08134 322 PELESHPDHALAKRLLpRGAGSVFSFDLKGGRAAGRKFIESLKLFSHLANVGDARSLVIHPASTTHFRMDAAALAAAGIG 401
|
410 420 430
....*....|....*....|....*....|..
gi 1059158380 371 DTLIRLSVGLEDEKDLLEDLDQALKAAAESGS 402
Cdd:PRK08134 402 EGTIRLSIGLEDADDLIDDLKRALKAAEKAGA 433
|
|
| PRK07049 |
PRK07049 |
cystathionine gamma-synthase family protein; |
14-397 |
5.89e-90 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 180809 [Multi-domain] Cd Length: 427 Bit Score: 279.63 E-value: 5.89e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 14 HFQHFATQAIHVGQEPEqWTSRAVVPLISLSTTF-----------------KQEAP-GQHSGFEYSRSGNPTRNCLEKAV 75
Cdd:PRK07049 14 RELHPETQMLNYGYDPE-LSEGAVKPPVFLTSTFvfrsaedgrdffdyvsgRKEPPaGEGAGLVYSRFNHPNSEIVEDRL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 76 AALDGAKYCLAFASGLAA-TVTITHLLKAGDQIICVDDVYGGTNRYFRQVASEFGLK-ISFVDCSKIKLLEAAITP---- 149
Cdd:PRK07049 93 AVYEGAESAALFSSGMSAiATTLLAFVRPGDVILHSQPLYGGTETLLAKTFRNFGVGaVGFADGLSEAAIGAAAEAaaak 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 150 -ETKLVWIETPTNPILKMIDIEA----CAHIVHKHGDI-ILVVDNTFMSPYFQRPLALGADICMCSATKYMNGHSDVVMG 223
Cdd:PRK07049 173 gRVSLILIETPANPTNSLVDVAAvrrvADAIEARQGHRpIIACDNTLLGPVFQKPLEHGADLSVYSLTKYVGGHSDLVAG 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 224 LVSVNcERLHNRLRFLQNSLGAVPSPLDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPGVEKVIYPGL--PSHPQHE 301
Cdd:PRK07049 253 AVLGR-KALIRQVRALRSAIGTQLDPHSCWMLGRSLETLVLRMERANRNARAVAEFLRDHPKVEKLHYLPFldPDSAYGA 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 302 LAKRQCTGCTGMITFYIKGTLQHAEIFLKNLKLFTLAESLGGFESLAELPAIMTHASVPKNDRDVLGISDTLIRLSVGLE 381
Cdd:PRK07049 332 VYKRQCTGAGSTFSFDIKGGQAAAFRFLNALQIFKLAVSLGGTESLASHPASMTHSGVPADVRERIGVLESTIRLSIGIE 411
|
410
....*....|....*.
gi 1059158380 382 DEKDLLEDLDQALKAA 397
Cdd:PRK07049 412 HPDDLIADLAQALDAA 427
|
|
| PRK07504 |
PRK07504 |
O-succinylhomoserine sulfhydrylase; Reviewed |
47-397 |
2.19e-88 |
|
O-succinylhomoserine sulfhydrylase; Reviewed
Pssm-ID: 168979 [Multi-domain] Cd Length: 398 Bit Score: 274.71 E-value: 2.19e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 47 FKQEAPGqhsgFEYSRSGNPTRNCLEKAVAALDGAKYCLAFASGLAA-TVTITHLLKAGDQIICVDDVYGGTNRYFRQVA 125
Cdd:PRK07504 50 FKGEDPG----FIYSRYSNPTVDMFEKRMCALEGAEDARATASGMAAvTAAILCQVKAGDHVVAARALFGSCRYVVETLL 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 126 SEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPILKMIDIEACAHIVHKHGdIILVVDNTFMSPYFQRPLALGADI 205
Cdd:PRK07504 126 PRYGIESTLVDGLDLDNWEKAVRPNTKVFFLESPTNPTLEVIDIAAVAKIANQAG-AKLVVDNVFATPLFQKPLELGAHI 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 206 CMCSATKYMNGHSDVVMGLV-SVNC---ERLHNRLRFLQNSLgavpSPLDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLE 281
Cdd:PRK07504 205 VVYSATKHIDGQGRCLGGVVlSDKAwieEHLQDYFRHTGPSL----SPFNAWTLLKGLETLPVRVRQQTESAAAIADFLA 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 282 SNPGVEKVIYPGLPSHPQHELAKRQCTGCTGMITFYIKGTLQHAEIFLKNLKLFTLAESLGGFESLAELPAIMTHASVPK 361
Cdd:PRK07504 281 GHPKVARVIYPGRADHPQADIIAKQMTGGSTLVAFELKGGKEAAFRFLNALKIVRISNNLGDAKSLITHPATTTHKNLSP 360
|
330 340 350
....*....|....*....|....*....|....*.
gi 1059158380 362 NDRDVLGISDTLIRLSVGLEDEKDLLEDLDQALKAA 397
Cdd:PRK07504 361 EARAELGISEGFLRLSAGLEDTDDLIEDLAAALKKV 396
|
|
| PRK07582 |
PRK07582 |
cystathionine gamma-lyase; Validated |
19-397 |
3.84e-85 |
|
cystathionine gamma-lyase; Validated
Pssm-ID: 236061 Cd Length: 366 Bit Score: 264.94 E-value: 3.84e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 19 ATQAIH-VGQEPEQWTSraVVPLISLSTTFKQEAPGQHSGFEYSRSGNPTRNCLEKAVAALDGAKyCLAFASGLAA-TVT 96
Cdd:PRK07582 5 GTRSVHaGGPEAVPGEP--VLPGPVFAAPYHLSPGEPTGPDTYGRASNPTWRALEAALGELEGAE-ALVFPSGMAAiTAV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 97 ITHLLKAGDQIICVDDVYGGTNRYFRQVASEFGLKISFVDCSKIklLEAAITPeTKLVWIETPTNPILKMIDIEACAHIV 176
Cdd:PRK07582 82 LRALLRPGDTVVVPADGYYQVRALAREYLAPLGVTVREAPTAGM--AEAALAG-ADLVLAETPSNPGLDVCDLAALAAAA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 177 HKHGdIILVVDNTFMSPYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVNCERLHNRLRFLQNSLGAVPSPLDCYLCN 256
Cdd:PRK07582 159 HAAG-ALLVVDNTTATPLGQRPLELGADLVVASDTKALTGHSDLLLGYVAGRDPELMAAVERWRLLAGAIPGPFEAWLAH 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 257 RGLKTLHVRMEKHFKNGMAVAQFLESNPGVEKVIYPGLPSHPQHELAKRQCTGCTGMITFYIkGTLQHAEIFLKNLKLFT 336
Cdd:PRK07582 238 RSLGTLGLRFARQCANALAVAELLAGHPAVRGVRYPGLPGDPAHEVAARQMRRFGGLVSFEL-ADAAAAERFVAASRLVV 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1059158380 337 LAESLGGfeslaelpaimTHASVPKNDRDVLGISDTLIRLSVGLEDEKDLLEDLDQALKAA 397
Cdd:PRK07582 317 AATSFGG-----------VHTSADRRARWGDAVPEGFVRLSCGIEDTDDLVADLERALDAL 366
|
|
| PRK05994 |
PRK05994 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
18-397 |
1.51e-83 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 180344 [Multi-domain] Cd Length: 427 Bit Score: 263.11 E-value: 1.51e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 18 FATQAIHVGQEPEQWTSRAVVPlISLSTTFKQEAPG--------QHSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAFAS 89
Cdd:PRK05994 8 FATLAVHAGAQPDPTTGARATP-IYQTTSFVFNDADhaaslfglQAFGNIYTRITNPTNAVLEERVAALEGGTAALAVAS 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 90 GLAATVTITH-LLKAGDQIICVDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPILKMID 168
Cdd:PRK05994 87 GHAAQFLVFHtLLQPGDEFIAARKLYGGSINQFGHAFKSFGWQVRWADADDPASFERAITPRTKAIFIESIANPGGTVTD 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 169 IEACAHIVHKHGdIILVVDNTFMSPYFQRPLALGADICMCSATKYMNGHSDVVMGLV----------------------S 226
Cdd:PRK05994 167 IAAIAEVAHRAG-LPLIVDNTLASPYLIRPIEHGADIVVHSLTKFLGGHGNSMGGIIvdggtfdwsksgkypmlseprpE 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 227 VNCERLHNRL---------RFLQ-NSLGAVPSPLDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPGVEKVIYPGLPS 296
Cdd:PRK05994 246 YHGLVLHETFgnfafaiaaRVLGlRDLGPAISPFNAFLILTGIETLPLRMQRHSDNALAVAEWLKGHPKVSWVNYAGLPD 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 297 HPQHELAKRQCTGCTGMI-TFYIKGTLQHAEIFLKNLKLFTLAESLGGFESLAELPAIMTHASVPKNDRDVLGISDTLIR 375
Cdd:PRK05994 326 DPYHALAQKYSPKGAGAVfTFGLKGGYEAGVKLVSSLKLFSHLANIGDTRSLVIHPASTTHRQLTDEQKVAAGAGPDVVR 405
|
410 420
....*....|....*....|..
gi 1059158380 376 LSVGLEDEKDLLEDLDQALKAA 397
Cdd:PRK05994 406 LSIGIEDVDDIIADLEQALAKA 427
|
|
| PRK07812 |
PRK07812 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
17-398 |
1.95e-82 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 236105 Cd Length: 436 Bit Score: 260.45 E-value: 1.95e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 17 HFATQAIHVGQEPEQWT-SRAVVPLISLSTTFKQEAPGQ------HSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAFAS 89
Cdd:PRK07812 13 SFETKQIHAGQTPDPATnARALPIYQTTSYTFDDTDHAAalfglaEPGNIYTRIMNPTQDVVEQRIAALEGGVAALLLAS 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 90 GLAA-TVTITHLLKAGDQIICVDDVYGGTNRYFRQVASEFGLKISFV-DCSKIKLLEAAITPETKLVWIETPTNPILKMI 167
Cdd:PRK07812 93 GQAAeTFAILNLAGAGDHIVSSPRLYGGTYNLFHYTLPKLGIEVSFVeDPDDLDAWRAAVRPNTKAFFAETISNPQIDVL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 168 DIEACAHIVHKHGdIILVVDNTFMSPYFQRPLALGADICMCSATKYMNGHSDVVMGLVsVNCER---------------- 231
Cdd:PRK07812 173 DIPGVAEVAHEAG-VPLIVDNTIATPYLIRPLEHGADIVVHSATKYLGGHGTAIAGVI-VDGGTfdwtqgrfpgfttpdp 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 232 ----------------LHNRLRFLQNsLGAVPSPLDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPGVEKVIYPGLP 295
Cdd:PRK07812 251 syhgvvfaelgppayaLKARVQLLRD-LGSAISPFNAFLIAQGLETLSLRIERHVANAQRVAEFLEARDEVASVNYAGLP 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 296 SHPQHELAKRQCTGCTGMI-TFYIKGTLQHAEIFLKNLKLFTLAESLGGFESLAELPAIMTHASVPKNDRDVLGISDTLI 374
Cdd:PRK07812 330 SSPWYERAKRLAPKGTGAVlSFELAGGVEAGKAFVNALTLHSHVANIGDVRSLVIHPASTTHSQLTPEEQLATGVTPGLV 409
|
410 420
....*....|....*....|....
gi 1059158380 375 RLSVGLEDEKDLLEDLDQALKAAA 398
Cdd:PRK07812 410 RLAVGIEGIDDILADLEAGFAAAK 433
|
|
| PRK06084 |
PRK06084 |
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; |
20-398 |
1.40e-81 |
|
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
Pssm-ID: 180392 [Multi-domain] Cd Length: 425 Bit Score: 257.91 E-value: 1.40e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 20 TQAIHVGQEPEQwTSRAVVPLISLSTTFKQEAPgQH---------SGFEYSRSGNPTRNCLEKAVAALDGAKYCLAFASG 90
Cdd:PRK06084 5 TLAIHAGYSPDP-TTKAVAVPIYQTTSYAFDDT-QHgadlfdlkvPGNIYTRIMNPTNDVLEQRVAALEGGVGALAVASG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 91 LAA-TVTITHLLKAGDQIICVDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPILKMIDI 169
Cdd:PRK06084 83 MAAiTYAIQTIAEAGDNIVSVAKLYGGTYNLLAHTLPRIGIETRFAAHDDIAALEALIDERTKAVFCESIGNPAGNIIDI 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 170 EACAHIVHKHGdIILVVDNTFMSPYFQRPLALGADICMCSATKYMNGHSDVVMGLV--SVNCERLHNRLRF-LQN----- 241
Cdd:PRK06084 163 QALADAAHRHG-VPLIVDNTVATPVLCRPFEHGADIVVHSLTKYIGGHGTSIGGIVvdSGKFPWAEHKERFaLLNtpdps 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 242 -------------------------SLGAVPSPLDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPGVEKVIYPGLPS 296
Cdd:PRK06084 242 yhgvtyteafgpaafigrcrvvplrNMGAALSPFNAFLILQGLETLALRMERHTENALKVARYLQQHPQVAWVKYAGLPD 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 297 HPQHELAKRQCTGC-TGMITFYIKGTLQHAEIFLKNLKLFTLAESLGGFESLAELPAIMTHASVPKNDRDVLGISDTLIR 375
Cdd:PRK06084 322 HPEHELARRYMGGKpASILSFGIKGGQAAGARFIDALKLVVRLVNIGDAKSLACHPASTTHRQLNDEELEKAGVSRDMVR 401
|
410 420
....*....|....*....|...
gi 1059158380 376 LSVGLEDEKDLLEDLDQALKAAA 398
Cdd:PRK06084 402 LSIGIEHIDDIIADLAQALDASK 424
|
|
| PRK05968 |
PRK05968 |
hypothetical protein; Provisional |
8-399 |
1.48e-80 |
|
hypothetical protein; Provisional
Pssm-ID: 168320 [Multi-domain] Cd Length: 389 Bit Score: 253.85 E-value: 1.48e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 8 SQGFLPHfqhfaTQAIHVGQEPEQWTSRAVVPLI---SLsTTFKQEAP------GQHSGFEYSRSGNPTRNCLEKAVAAL 78
Cdd:PRK05968 2 NDGLDPF-----DLAALITAHDEGNAFDAVVPPIfqtSL-FTFDSYDEmedvyaGEKVRPIYSRGDNPTVRAFEEMLAKL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 79 DGAKYCLAFASGLAA-TVTITHLLKAGDQIICVDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAItPETKLVWIE 157
Cdd:PRK05968 76 EGAEDARGFASGMAAiSSTVLSFVEPGDRIVAVRHVYPDAFRLFETILKRMGVEVDYVDGRDEEAVAKAL-PGAKLLYLE 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 158 TPTNPILKMIDIEACAHIVHKHGdIILVVDNTFMSPYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVNCERLhNRLR 237
Cdd:PRK05968 155 SPTSWVFELQDVAALAALAKRHG-VVTMIDNSWASPVFQRPITLGVDLVIHSASKYLGGHSDTVAGVVAGSKEHI-ARIN 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 238 FLQNS-LGAVPSPLDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPGVEKVIYPGLPSHPQHELakrqcTGCTGMITF 316
Cdd:PRK05968 233 AEAYPyLGAKLSPFEAWLLLRGLRTLPLRMKAHEASALEIARRLKAHPVVERVCHPALANHPPAGL-----SGTSGLFSF 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 317 YIKGTLQHAEiFLKNLKLFTLAESLGGFESLAeLPAIMTHASVPK-NDRDVLGISDTLIRLSVGLEDEKDLLEDLDQALK 395
Cdd:PRK05968 308 IFREGIDVRA-FADALKLFRLGVSWGGHESLV-VPAEVVLQQKAQpNSAARFGVSPRSVRLHVGLEGTEALWADLEQALA 385
|
....
gi 1059158380 396 AAAE 399
Cdd:PRK05968 386 AASR 389
|
|
| PRK05967 |
PRK05967 |
cystathionine beta-lyase; Provisional |
20-398 |
1.64e-80 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 235657 [Multi-domain] Cd Length: 395 Bit Score: 253.96 E-value: 1.64e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 20 TQAIHVGQEPEQWTSRAVVPLISLSTTFKQEAPGQHSG---FEYSRSGNPTRNCLEKAVAALDGAKYCLAFASGLAA-TV 95
Cdd:PRK05967 15 TRLAHDGNDPGDYHGFVNPPVVHASTVLFPDAETMATRgqkYTYGTRGTPTTDALCKAIDALEGSAGTILVPSGLAAvTV 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 96 TITHLLKAGDQIICVDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPILKMIDIEACAHI 175
Cdd:PRK05967 95 PFLGFLSPGDHALIVDSVYYPTRHFCDTMLKRLGVEVEYYDPEIGAGIAKLMRPNTKVVHTEAPGSNTFEMQDIPAIAEA 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 176 VHKHGDIILVvDNTFMSPYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVNcERLHNRLRFLQNSLGAVPSPLDCYLC 255
Cdd:PRK05967 175 AHRHGAIVMM-DNTWATPLYFRPLDFGVDISIHAATKYPSGHSDILLGTVSAN-EKCWPQLLEAHGTLGLCAGPDDTYQI 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 256 NRGLKTLHVRMEKHFKNGMAVAQFLESNPGVEKVIYPGLPSHPQHELAKRQCTGCTGMITFYIKGTL----QHAEIFLKN 331
Cdd:PRK05967 253 LRGLRTMGIRLEHHRKSALEIARWLEGRPDVARVLHPALPSFPGHEIWKRDFSGASGIFSFVLAAGPekgkAKAHAFLDA 332
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1059158380 332 LKLFTLAESLGGFESLAeLPAIMTHASVPKNDRDvlgisDTLIRLSVGLEDEKDLLEDLDQALKAAA 398
Cdd:PRK05967 333 LEIFGLGYSWGGYESLA-LHVKLGDRTVAKAPYA-----GPVIRLQIGLEDVPDLKADLERGFAAAS 393
|
|
| PRK07810 |
PRK07810 |
O-succinylhomoserine sulfhydrylase; Provisional |
12-395 |
1.43e-79 |
|
O-succinylhomoserine sulfhydrylase; Provisional
Pssm-ID: 236103 [Multi-domain] Cd Length: 403 Bit Score: 251.96 E-value: 1.43e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 12 LPHFQHFATQAIHVGQEPEQW--TSRAvvplISLSTTFKQEAP--------GQHSGFEYSRSGNPTRNCLEKAVAALDGA 81
Cdd:PRK07810 10 LPDGVSQATIGVRGGLLRSGFeeTAEA----LYLTSGYVYESAaaaeaaftGELDRFVYSRYGNPTVSMFEERLRLIEGA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 82 KYCLAFASGLAATVT-ITHLLKAGDQIICVDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPT 160
Cdd:PRK07810 86 EACFATASGMSAVFTaLGALLGAGDRLVAARSLFGSCFVVCNEILPRWGVETVFVDGEDLSQWEEALSVPTQAVFFETPS 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 161 NPILKMIDIEACAHIVHKHGDIIlVVDNTFMSPYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVNCERLHNRLRFLQ 240
Cdd:PRK07810 166 NPMQSLVDIAAVSELAHAAGAKV-VLDNVFATPLLQRGLPLGADVVVYSGTKHIDGQGRVLGGAILGDREYIDGPVQKLM 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 241 NSLGAVPSPLDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPGVEKVIYPGLPSHPQHELAKRQCTGCTGMITFYIKG 320
Cdd:PRK07810 245 RHTGPALSAFNAWVLLKGLETLALRVRHSNASALRIAEFLEGHPAVRWVRYPFLPSHPQYDLAKRQMSGGGTVVTFELDA 324
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1059158380 321 TL----QHAEIFLKNLKLFTLAESLGGFESLAELPAIMTHASVPKNDRDVLGISDTLIRLSVGLEDEKDLLEDLDQALK 395
Cdd:PRK07810 325 PEdaakKRAFEVLDKLRVIDISNNLGDAKSLITHPATTTHRAMGPEGRAAIGLGDGVVRLSVGLEDTDDLIADLDRALG 403
|
|
| PRK05939 |
PRK05939 |
cystathionine gamma-synthase family protein; |
53-397 |
4.41e-79 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 235650 [Multi-domain] Cd Length: 397 Bit Score: 250.38 E-value: 4.41e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 53 GQHSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAFASGLAA-TVTITHLLKAGDQIICVDDVYGGTNRYFRQVAsEFGLK 131
Cdd:PRK05939 34 GKKPGFTYARQGTPTTAALEAKITKMEGGVGTVCFATGMAAiAAVFLTLLRAGDHLVSSQFLFGNTNSLFGTLR-GLGVE 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 132 ISFVDCSKIKLLEAAITPETKLVWIETPTNPILKMIDIEACAHIVHKHGdIILVVDNTFMSPYFQRPLALGADICMCSAT 211
Cdd:PRK05939 113 VTMVDATDVQNVAAAIRPNTRMVFVETIANPGTQVADLAGIGALCRERG-LLYVVDNTMTSPWLFRPKDVGASLVINSLS 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 212 KYMNGHSDVVMGLVS----------VNCERLHNR---------------LRflqnSLGAVPSPLDCYLCNRGLKTLHVRM 266
Cdd:PRK05939 192 KYIAGHGNALGGAVTdtglfdwsayPNIFPAYRKgdpqqwgltqirkkgLR----DMGATLSSEAAHRIAIGAETLALRV 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 267 EKHFKNGMAVAQFLESNPGVEKVIYPGLPSHPQHELAKRQCTGCTGMITFYIKGTLQHAEiFLKNLKLFTLAESLGGFES 346
Cdd:PRK05939 268 DRSCSNALALAQFLEAHPKVARVYYPGLASHPQHARATELFRHYGGLLSFELADGIDCFD-FLNRLKLVIKATHLGDTRT 346
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1059158380 347 LAeLPAIMT--HASVPKNdRDVLGISDTLIRLSVGLEDEKDLLEDLDQALKAA 397
Cdd:PRK05939 347 LV-IPVAPTiyYEMGAER-RASMGIADSLIRVSVGIEDEADLIADFEQALDAT 397
|
|
| cysta_beta_ly_B |
TIGR01324 |
cystathionine beta-lyase, bacterial; This model represents cystathionine beta-lyase (alternate ... |
20-397 |
3.16e-75 |
|
cystathionine beta-lyase, bacterial; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 130391 [Multi-domain] Cd Length: 377 Bit Score: 239.78 E-value: 3.16e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 20 TQAIHVGQEPEQWtSRAVVPLISLSTT--FKQEAP--GQHSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAFASGLAA-T 94
Cdd:TIGR01324 1 TRLIHSGRQPRFS-QGSVNPPLQRASTvlFDSHAAqrRAKGELTYGRRGTLTHFALQDAMCELEGGAGCYLYPSGLAAvT 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 95 VTITHLLKAGDQIICVDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPILKMIDIEACAH 174
Cdd:TIGR01324 80 NSILAFVKAGDHVLMVDSAYEPTRYFCDIVLKRMGVDITYYDPLIGEDIATLIQPNTKVLFLEAPSSITFEIQDIPAIAK 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 175 IVHKHGdIILVVDNTFMSPYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVnCERLHNRLRFLQNSLGAVPSPLDCYL 254
Cdd:TIGR01324 160 AARNPG-IVIMIDNTWAAGLLFKPLEHGVDISIQAGTKYLVGHSDIMIGTVVA-NARTWDQLREHSYLMGQMVDADDAYT 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 255 CNRGLKTLHVRMEKHFKNGMAVAQFLESNPGVEKVIYPGLPSHPQHELAKRQCTGCTGMITFYIKGTLQHA-EIFLKNLK 333
Cdd:TIGR01324 238 TLRGLRTLGVRLKQHQESSLAIAKWLSEQPEVARVLHPALPSCPGHEFWKRDFSGSSGLFSFVLQRLTQKQvHAFLDHLQ 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1059158380 334 LFTLAESLGGFESLAeLPAIMTHASVPKNDRDVLGisdTLIRLSVGLEDEKDLLEDLDQALKAA 397
Cdd:TIGR01324 318 LFGLGYSWGGYESLA-LCNQPELGHRPNIKRNLEG---PLIRVHIGLENVDDLKADLKAGFEAI 377
|
|
| PRK07050 |
PRK07050 |
cystathionine beta-lyase; Provisional |
17-397 |
3.25e-71 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 180810 [Multi-domain] Cd Length: 394 Bit Score: 230.00 E-value: 3.25e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 17 HFATQAIH-VGQEPEQWTSrAVVPLISLSTT-FKQEAP------GQHSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAFA 88
Cdd:PRK07050 9 ALQTRIVQpDDQIPPGFRS-FVTPVARASTVvFPDLATmraldwRQDVQWRYGLHATPTSLALAQRLAEIEGGRHALLQP 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 89 SGLAATVTITH-LLKAGDQIICVDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPILKMI 167
Cdd:PRK07050 88 SGLAAISLVYFgLVKAGDDVLIPDNAYGPNRDHGEWLARDFGITVRFYDPLIGAGIADLIQPNTRLIWLEAPGSVTMEVP 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 168 DIEACAHIVHKHGdIILVVDNTFMSPYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVNCERLHNRLRFLQNSLGAVP 247
Cdd:PRK07050 168 DVPAITAAARARG-VVTAIDNTYSAGLAFKPFEHGVDISVQALTKYQSGGSDVLMGATITADAELHAKLKLARMRLGIGV 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 248 SPLDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPGVEKVIYPGLPSHPQHELAKRQCTGCTGM--ITFYIKGTLQHA 325
Cdd:PRK07050 247 SADDCSLVLRGLPSLQVRLAAHDRSALEVAEWLKARPEIATVLHPALPDCPGHAFWMRDFTGAGGLfsVVFDERYSPAQV 326
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1059158380 326 EIFLKNLKLFTLAESLGGFESLAeLPaimthASVPKNDRDVLGISDTLIRLSVGLEDEKDLLEDLDQALKAA 397
Cdd:PRK07050 327 DAFVEALELFAIGWSWGGACSLA-MP-----YDVASMRTAKWPHRGTLVRLYIGLEDEADLIADLEQALEAA 392
|
|
| PRK09028 |
PRK09028 |
cystathionine beta-lyase; Provisional |
19-394 |
1.39e-70 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 181615 [Multi-domain] Cd Length: 394 Bit Score: 228.46 E-value: 1.39e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 19 ATQAIHVGQEpEQWTSRAVVPLISLSTT--FKQEAPGQHSGFE-------YSRSGNPTRNCLEKAVAALDGAKYCLAFAS 89
Cdd:PRK09028 6 ATKIVSAGRD-KKWTKGVINPPVFRASTvvFDTVAEMRHAAKNrangemfYGRRGTPTHFAFQAAIVELEGGAGTALYPS 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 90 GLAA-TVTITHLLKAGDQIICVDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPILKMID 168
Cdd:PRK09028 85 GAAAiSNALLSFLKAGDHLLMVDSCYEPTRDLCDKILKGFGIETTYYDPMIGEGIRELIRPNTKVLFLESPGSITMEVQD 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 169 IEACAHIVHKHgDIILVVDNTFMSPYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVNcERLHNRLRFLQNSLGAVPS 248
Cdd:PRK09028 165 VPTLSRIAHEH-DIVVMLDNTWASPINSRPFEMGVDISIQAATKYIVGHSDVMLGTATAN-EKHWDQLREHSYLMGQCTS 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 249 PLDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPGVEKVIYPGLPSHPQHELAKRQCTGCTGMITFYIK-GTLQHAEI 327
Cdd:PRK09028 243 PDDVYLAMRGLRTLGVRLAQHEKNALKVANWLATRPEVDHVRHPAFETCPGHEFFKRDFSGSNGLFSFVLKqGDPKAVTA 322
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1059158380 328 FLKNLKLFTLAESLGGFESLaelpaIMTHASVPKNdRDVLG--ISDTLIRLSVGLEDEKDLLEDLDQAL 394
Cdd:PRK09028 323 LVEGMQHFKMGFSWGGFESL-----ILGVFGINKL-RTATNwdFSKPLIRLHIGLEDVDDLIADLEAGF 385
|
|
| PRK05613 |
PRK05613 |
O-acetylhomoserine/O-acetylserine sulfhydrylase; |
18-396 |
3.23e-66 |
|
O-acetylhomoserine/O-acetylserine sulfhydrylase;
Pssm-ID: 168128 [Multi-domain] Cd Length: 437 Bit Score: 218.20 E-value: 3.23e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 18 FATQAIHVGQEPEQWTSRAVVPlISLSTTF--------KQEAPGQHSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAFAS 89
Cdd:PRK05613 14 FETRSIHAGQSVDSDTSARNLP-IYQTTSYvfdsaehaKQRFALEDLGPIYSRLTNPTVEALENRIASLEGGVHAVAFAS 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 90 GLAA-TVTITHLLKAGDQIICVDDVYGGTNRYFRQVASEFGLKISFV-DCSKIKLLEAAITPETKLVWIETPTNPILKMI 167
Cdd:PRK05613 93 GQAAeTAAILNLAGAGDHIVTSPRLYGGTETLFLVTLNRLGIEVTFVeNPDDPESWQAAVQPNTKAFFGETFANPQADVL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 168 DIEACAHIVHKHgDIILVVDNTFMSPYFQRPLALGADICMCSATKYMNGHSDVVMGLVS--------------------V 227
Cdd:PRK05613 173 DIPAVAEVAHRN-QVPLIVDNTIATAALVRPLELGADVVVASLTKFYTGNGSGLGGVLIdggkfdwtverdgkpvfpyfV 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 228 NCERLHNRLRF---------------LQNSLGAVPSPLDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPGVEKVIYP 292
Cdd:PRK05613 252 TPDPAYHGLKYadlgapafglkaragLLRDTGATLSPFNAWVTAQGLDTLSLRLERHNENAIKVAEFLNNHEKVAKVNFA 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 293 GLPSHPQHELAKRQCTGCTG-MITFYIKGTLQHAEIFLKNLKLFTLAESLGGFESLAELPAIMTHASVPKNDRDVLGISD 371
Cdd:PRK05613 332 GLKDSPWYATKEKLGLKYTGsVLSFDIKGGKDEAWAFIDALKLHSNLANIGDVRSLVVHPATTTHSQSDEAGLARAGITQ 411
|
410 420
....*....|....*....|....*
gi 1059158380 372 TLIRLSVGLEDEKDLLEDLDQALKA 396
Cdd:PRK05613 412 ATVRLSVGIEDIDDIIADLEGGFAA 436
|
|
| PRK08114 |
PRK08114 |
cystathionine beta-lyase; Provisional |
16-391 |
5.49e-61 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 181231 [Multi-domain] Cd Length: 395 Bit Score: 203.40 E-value: 5.49e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 16 QHFATQAIHVGQEPeQWTSRAVVPLI--SLSTTF------KQEAPGQHSG--FeYSRSGNPTRNCLEKAVAALDGAKYCL 85
Cdd:PRK08114 4 KKLDTQLVNAGRSK-KYTQGSVNSVIqrASSLVFdsveakKHATRNRANGelF-YGRRGTLTHFSLQEAMCELEGGAGCA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 86 AFASGLAA-TVTITHLLKAGDQIICVDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPIL 164
Cdd:PRK08114 82 LYPCGAAAvANAILAFVEQGDHVLMTGTAYEPTQDFCSKILSKLGVTTTWFDPLIGADIAKLIQPNTKVVFLESPGSITM 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 165 KMIDIEACAHIVH-KHGDIILVVDNTFMSPYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVNcERLHNRLRflQNS- 242
Cdd:PRK08114 162 EVHDVPAIVAAVRsVNPDAVIMIDNTWAAGVLFKALDFGIDISIQAGTKYLVGHSDAMIGTAVAN-ARCWEQLR--ENSy 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 243 -LGAVPSPLDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPGVEKVIYPGLPSHPQHELAKRQCTGCTGMITFYIKGT 321
Cdd:PRK08114 239 lMGQMVDADTAYMTSRGLRTLGVRLRQHEESSLKVAEWLAEHPEVARVNHPALPGCKGHEFWKRDFTGSSGLFSFVLKKK 318
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1059158380 322 LQHAEI--FLKNLKLFTLAESLGGFESL------AELPAIMthasvPKNDRDVLGisdTLIRLSVGLEDEKDLLEDLD 391
Cdd:PRK08114 319 LTDEQLanYLDNFSLFSMAYSWGGFESLilanqpEEIAAIR-----PAGEVDFTG---TLIRLHIGLEDVDDLIADLA 388
|
|
| PRK06702 |
PRK06702 |
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; |
19-394 |
5.54e-55 |
|
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
Pssm-ID: 102505 [Multi-domain] Cd Length: 432 Bit Score: 188.72 E-value: 5.54e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 19 ATQAIHVGQEPEQWTSRaVVPLISlSTTFKQEAPG--------QHSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAFASG 90
Cdd:PRK06702 8 GTICVQGGYTPKNGEPR-VLPLYQ-STTYKYDTSDdlaalfnlEAEGYIYTRIGNPTLAAFEQKLAELEGGVGAVATASG 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 91 LAA-TVTITHLLKAGDQIICVDDVYGGTNRYFRQVASEFGLKISFVDCS-KIKLLEAAITPETKLVWIETPTNPILKMID 168
Cdd:PRK06702 86 QAAiMLAVLNICSSGDHLLCSSTVYGGTFNLFGVSLRKLGIDVTFFNPNlTADEIVALANDKTKLVYAESLGNPAMNVLN 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 169 IEACAHIVhKHGDIILVVDNTFMSPYFQRPLALGADICMCSATKYMNGHSDVVMGLVS---------------VNCERLH 233
Cdd:PRK06702 166 FKEFSDAA-KELEVPFIVDNTLATPYLCQAFEHGANIIVHSTTKYIDGHASSLGGIVIdggnfdwtngkypelVEPDPSY 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 234 NRLRFLQN----------------SLGAVPSPLDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPGVEKVIYPGLPSH 297
Cdd:PRK06702 245 HGVSYVQNfgaaayivkarvqllrDYGNCMSPFNAYISNIGLETLHLRMERHSENALAVAKWLADHERIEWVNYPGLDSN 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 298 PQHELAKRQCT-GCTGMITFYIKGTLQHAEIFLKNLKLFTLAESLGGFESLAELPAIMTHASVPKNDRDVLGISDTLIRL 376
Cdd:PRK06702 325 ENYSLAQKYLKkGASGVLTFGIKGGLEAAKEFIANVKLATLVTHVADARTCVIHPASTTHRQLSAEDQRLAGVTSDLIRL 404
|
410
....*....|....*...
gi 1059158380 377 SVGLEDEKDLLEDLDQAL 394
Cdd:PRK06702 405 SVGIEDVSDIIADLEAAL 422
|
|
| PLN02242 |
PLN02242 |
methionine gamma-lyase |
42-379 |
2.01e-51 |
|
methionine gamma-lyase
Pssm-ID: 215134 Cd Length: 418 Bit Score: 178.81 E-value: 2.01e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 42 SLSTTFKQEAPGQHSGFEYSRSGNPTRNCLEKAVAALDG--AKYCLAfaSGLAA-TVTITHLLKAGDQIICVDDVYGGTN 118
Cdd:PLN02242 52 TMRRMFSGELGPDRDFYIYSRHFNPTVLNLGRQMAALEGteAAYCTA--SGMSAiSSVLLQLCSSGGHVVASNTLYGGTH 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 119 RYFRQ-VASEFGLKISFVDCSKIKLLEAAITP-ETKLVWIETPTNPILKMIDIEACAHIVHKHGdIILVVDNTFmSPYFQ 196
Cdd:PLN02242 130 ALLAHfLPRKCNITTTFVDITDLEAVKKAVVPgKTKVLYFESISNPTLTVADIPELARIAHEKG-VTVVVDNTF-APMVL 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 197 RPLALGADICMCSATKYMNGHSDVVMGLVSVNCERLHNRLRFLQNS---LGAVPSPLDCYLCNRGLKTLHVRMEKHFKNG 273
Cdd:PLN02242 208 SPARLGADVVVHSISKFISGGADIIAGAVCGPAELVNSMMDLHHGAlmlLGPTMNPKVAFELSERLPHLSLRMKEHCRRA 287
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 274 MAVAQFLESnPGVeKVIYPGLPSHPQHELAKRQ---CTGCTGMITFYIkGTLQHAEIFLKNLKLFT----LAESLGGFES 346
Cdd:PLN02242 288 MEYAKRMKE-LGL-KVIYPGLEDHPQHALLKSMankGYGFGGLLCLDM-DTEERANRLMRYLQNSTqfgfMAVSLGYYET 364
|
330 340 350
....*....|....*....|....*....|...
gi 1059158380 347 LAELPAIMTHASVPKNDRDVLGISDTLIRLSVG 379
Cdd:PLN02242 365 LMSCSGSSTSSELDPEEKAAAGISPGLVRMSVG 397
|
|
| AAT_I |
cd01494 |
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ... |
71-216 |
4.60e-12 |
|
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).
Pssm-ID: 99742 [Multi-domain] Cd Length: 170 Bit Score: 63.94 E-value: 4.60e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 71 LEKAVAAL--DGAKYCLAFASGLAATVTITH-LLKAGDQIICVDDVYGGTNRYFrqvASEFGLKISFVD--------CSK 139
Cdd:cd01494 5 LEEKLARLlqPGNDKAVFVPSGTGANEAALLaLLGPGDEVIVDANGHGSRYWVA---AELAGAKPVPVPvddagyggLDV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 140 IKLLEAAITPETKLVWIETPTNPILKMIDIEACAHIVHKHGdIILVVDNTFMSPY----FQRPLALGADICMCSATKYMN 215
Cdd:cd01494 82 AILEELKAKPNVALIVITPNTTSGGVLVPLKEIRKIAKEYG-ILLLVDAASAGGAspapGVLIPEGGADVVTFSLHKNLG 160
|
.
gi 1059158380 216 G 216
Cdd:cd01494 161 G 161
|
|
| AAT_like |
cd00609 |
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent ... |
100-315 |
8.00e-08 |
|
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. The major groups in this CD corresponds to Aspartate aminotransferase a, b and c, Tyrosine, Alanine, Aromatic-amino-acid, Glutamine phenylpyruvate, 1-Aminocyclopropane-1-carboxylate synthase, Histidinol-phosphate, gene products of malY and cobC, Valine-pyruvate aminotransferase and Rhizopine catabolism regulatory protein.
Pssm-ID: 99734 [Multi-domain] Cd Length: 350 Bit Score: 53.88 E-value: 8.00e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 100 LLKAGDQIICVDDVYGGtnryFRQVASEFGLKISFVDCSK-------IKLLEAAITPETKLVWIETPTNP---ILKMIDI 169
Cdd:cd00609 79 LLNPGDEVLVPDPTYPG----YEAAARLAGAEVVPVPLDEeggflldLELLEAAKTPKTKLLYLNNPNNPtgaVLSEEEL 154
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 170 EACAHIVHKHgDIILVVDNT---FMSPYFQRPLALGAD-----ICMCSATKYMNghsdvVMGL----VSVNCERLHNRLR 237
Cdd:cd00609 155 EELAELAKKH-GILIISDEAyaeLVYDGEPPPALALLDayervIVLRSFSKTFG-----LPGLrigyLIAPPEELLERLK 228
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 238 FLQNSLGAVPSPLDCYLCNRGLKTLHVRMEKHF----KNGMAVAQFLESNPGVEKV-------IYPGLPSHPQHELAKRQ 306
Cdd:cd00609 229 KLLPYTTSGPSTLSQAAAAAALDDGEEHLEELReryrRRRDALLEALKELGPLVVVkpsggffLWLDLPEGDDEEFLERL 308
|
....*....
gi 1059158380 307 CTGCTGMIT 315
Cdd:cd00609 309 LLEAGVVVR 317
|
|
| WecE |
COG0399 |
dTDP-4-amino-4,6-dideoxygalactose transaminase [Cell wall/membrane/envelope biogenesis]; |
71-241 |
2.28e-07 |
|
dTDP-4-amino-4,6-dideoxygalactose transaminase [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440168 Cd Length: 364 Bit Score: 52.38 E-value: 2.28e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 71 LEKAVAALDGAKYCLAFASGLAATVTITHLL--KAGDQIICVDdvYGgtnryFrqVAS-----EFGLKISFVDCSK---- 139
Cdd:COG0399 35 FEEEFAAYLGVKHAVAVSSGTAALHLALRALgiGPGDEVITPA--FT-----F--VATanailYVGATPVFVDIDPdtyn 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 140 --IKLLEAAITPETKLVwietptnpIL-----KMIDIEACAHIVHKHGdIILVVDN--TFMSPYFQRPLALGADICMCS- 209
Cdd:COG0399 106 idPEALEAAITPRTKAI--------IPvhlygQPADMDAIMAIAKKHG-LKVIEDAaqALGATYKGKKVGTFGDAGCFSf 176
|
170 180 190
....*....|....*....|....*....|....*.
gi 1059158380 210 -ATK---YMNGhsdvvmGLVSVNCERLHNRLRFLQN 241
Cdd:COG0399 177 yPTKnltTGEG------GAVVTNDEELAERARSLRN 206
|
|
| DegT_DnrJ_EryC1 |
pfam01041 |
DegT/DnrJ/EryC1/StrS aminotransferase family; The members of this family are probably all ... |
71-241 |
1.83e-06 |
|
DegT/DnrJ/EryC1/StrS aminotransferase family; The members of this family are probably all pyridoxal-phosphate-dependent aminotransferase enzymes with a variety of molecular functions. The family includes StsA, StsC and StsS. The aminotransferase activity was demonstrated for purified StsC protein as the L-glutamine:scyllo-inosose aminotransferase EC:2.6.1.50, which catalyzes the first amino transfer in the biosynthesis of the streptidine subunit of streptomycin.
Pssm-ID: 395827 Cd Length: 360 Bit Score: 49.59 E-value: 1.83e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 71 LEKAVAALDGAKYCLAFASGLAATVTITHLLKA--GDQIICVDDVYGGTNryfrQVASEFGLKISFVD------CSKIKL 142
Cdd:pfam01041 29 FERAFAAYLGVKHAIAVSSGTAALHLALRALGVgpGDEVITPSFTFVATA----NAALRLGAKPVFVDidpdtyNIDPEA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 143 LEAAITPETKLVwieTPTNPILKMIDIEACAHIVHKHGdIILVVD--NTFMSPYFQRPLALGADICMCS--ATKYM---N 215
Cdd:pfam01041 105 IEAAITPRTKAI---IPVHLYGQPADMDAIRAIAARHG-LPVIEDaaHALGATYQGKKVGTLGDAATFSfhPTKNLttgE 180
|
170 180
....*....|....*....|....*.
gi 1059158380 216 GhsdvvmGLVSVNCERLHNRLRFLQN 241
Cdd:pfam01041 181 G------GAVVTNDPELAEKARVLRN 200
|
|
| AHBA_syn |
cd00616 |
3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal ... |
71-188 |
2.47e-06 |
|
3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary metabolites. Some well studied proteins in this CD are AHBA_synthase, protein product of pleiotropic regulatory gene degT, Arnb aminotransferase and pilin glycosylation protein. The prototype of this family, the AHBA_synthase, is a dimeric PLP dependent enzyme. AHBA_syn is the terminal enzyme of 3-amino-5-hydroxybenzoic acid (AHBA) formation which is involved in the biosynthesis of ansamycin antibiotics, including rifamycin B. Some members of this CD are involved in 4-amino-6-deoxy-monosaccharide D-perosamine synthesis. Perosamine is an important element in the glycosylation of several cell products, such as antibiotics and lipopolysaccharides of gram-positive and gram-negative bacteria. The pilin glycosylation protein encoded by gene pglA, is a galactosyltransferase involved in pilin glycosylation. Additionally, this CD consists of ArnB (PmrH) aminotransferase, a 4-amino-4-deoxy-L-arabinose lipopolysaccharide-modifying enzyme. This CD also consists of several predicted pyridoxal phosphate-dependent enzymes apparently involved in regulation of cell wall biogenesis. The catalytic lysine which is present in all characterized PLP dependent enzymes is replaced by histidine in some members of this CD.
Pssm-ID: 99740 [Multi-domain] Cd Length: 352 Bit Score: 49.46 E-value: 2.47e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 71 LEKAVAALDGAKYCLAFASGLAATVTITHLL--KAGDQIICvddvyggTNRYFrqVAS-----EFGLKISFVDCSK---- 139
Cdd:cd00616 23 FEKAFAEYLGVKYAVAVSSGTAALHLALRALgiGPGDEVIV-------PSFTF--VATanailLLGATPVFVDIDPdtyn 93
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 1059158380 140 --IKLLEAAITPETKLVwieTPTNPILKMIDIEACAHIVHKHGdIILVVDN 188
Cdd:cd00616 94 idPELIEAAITPRTKAI---IPVHLYGNPADMDAIMAIAKRHG-LPVIEDA 140
|
|
| PRK09082 |
PRK09082 |
methionine aminotransferase; Validated |
66-187 |
1.49e-05 |
|
methionine aminotransferase; Validated
Pssm-ID: 181642 [Multi-domain] Cd Length: 386 Bit Score: 46.83 E-value: 1.49e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 66 PTRNCLEKAVAALDGAKYClafaSGLAATVT----------ITHLLKAGDQIICVDDVY----------GGTNRYFRQVA 125
Cdd:PRK09082 71 ALREAIAAKTARLYGRQYD----ADSEITVTagatealfaaILALVRPGDEVIVFDPSYdsyapaielaGGRAVRVALQP 146
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1059158380 126 SEFGlkisfVDCSKIKlleAAITPETKLVWIETPTNP---ILKMIDIEACAHIVHKHgDIILVVD 187
Cdd:PRK09082 147 PDFR-----VDWQRFA---AAISPRTRLIILNTPHNPsgtVWSAADMRALWQLIAGT-DIYVLSD 202
|
|
| AspB |
COG0436 |
Aspartate/methionine/tyrosine aminotransferase [Amino acid transport and metabolism]; ... |
75-188 |
1.34e-04 |
|
Aspartate/methionine/tyrosine aminotransferase [Amino acid transport and metabolism]; Aspartate/methionine/tyrosine aminotransferase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis
Pssm-ID: 440205 [Multi-domain] Cd Length: 387 Bit Score: 43.97 E-value: 1.34e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 75 VAALDGAKYCLAFAsgLAAtvtithLLKAGDQIICVD---DVYggtnryfRQVASEFGLKISFVDCSK-------IKLLE 144
Cdd:COG0436 93 ILVTNGAKEALALA--LLA------LLNPGDEVLVPDpgyPSY-------RAAVRLAGGKPVPVPLDEengflpdPEALE 157
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 1059158380 145 AAITPETKLVWIETPTNP---ILKMIDIEACAHIVHKHgDIILVVDN 188
Cdd:COG0436 158 AAITPRTKAIVLNSPNNPtgaVYSREELEALAELAREH-DLLVISDE 203
|
|
| PRK12414 |
PRK12414 |
putative aminotransferase; Provisional |
68-190 |
2.07e-04 |
|
putative aminotransferase; Provisional
Pssm-ID: 183514 Cd Length: 384 Bit Score: 43.24 E-value: 2.07e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 68 RNCLEKAVAALDGAKY-------CLAFAS-GLAATvtITHLLKAGDQIICVD---DVYGGTNRYfrQVASEFGLKISF-- 134
Cdd:PRK12414 72 REALAEKTERLYGARYdpasevtVIASASeGLYAA--ISALVHPGDEVIYFEpsfDSYAPIVRL--QGATPVAIKLSPed 147
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1059158380 135 --VDCSKIKlleAAITPETKLVWIETPTNP---ILKMIDIEACAHIVhKHGDIILVVDNTF 190
Cdd:PRK12414 148 frVNWDEVA---AAITPRTRMIIVNTPHNPsatVFSAADLARLAQLT-RNTDIVILSDEVY 204
|
|
| Aminotran_1_2 |
pfam00155 |
Aminotransferase class I and II; |
71-187 |
4.02e-04 |
|
Aminotransferase class I and II;
Pssm-ID: 395103 [Multi-domain] Cd Length: 351 Bit Score: 42.29 E-value: 4.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059158380 71 LEKAVAALDGAKYCLA--------FASG-LAATVTITHLLKAGDQIICVDD-VYGGTNRYFRqvASefGLKISFVDCSK- 139
Cdd:pfam00155 44 LREALAKFLGRSPVLKldreaavvFGSGaGANIEALIFLLANPGDAILVPApTYASYIRIAR--LA--GGEVVRYPLYDs 119
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1059158380 140 ------IKLLEAAITPETKLVWIETPTNP---ILKMIDIEACAHIVHKHGdIILVVD 187
Cdd:pfam00155 120 ndfhldFDALEAALKEKPKVVLHTSPHNPtgtVATLEELEKLLDLAKEHN-ILLLVD 175
|
|
| PRK07682 |
PRK07682 |
aminotransferase; |
143-187 |
7.23e-03 |
|
aminotransferase;
Pssm-ID: 181082 [Multi-domain] Cd Length: 378 Bit Score: 38.56 E-value: 7.23e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 1059158380 143 LEAAITPETKLVWIETPTNP---ILKMIDIEACAHIVHKHgDIILVVD 187
Cdd:PRK07682 147 IEAAITAKTKAILLCSPNNPtgaVLNKSELEEIAVIVEKH-DLIVLSD 193
|
|
| |
