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Conserved domains on  [gi|1060099343|ref|NP_001317528|]
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zinc finger transcription factor Trps1 isoform 4 [Homo sapiens]

Protein Classification

GATA-type transcription factor( domain architecture ID 10078896)

GATA-type transcription factor binds to the DNA consensus sequence [AT]GATA[AG] and may function as a transcription factor/regulator

CATH:  3.30.50.10
Gene Ontology:  GO:0003700|GO:0006357|GO:0008270|GO:0043565
PubMed:  31574210

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 895-951 3.97e-14

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


:

Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 67.78  E-value: 3.97e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1060099343  895 FCANCLTTKTSLWRKNANGG-YVCNACGLYQKLHSTPRPLNiiKQNNGEqiIRRRTRK 951
Cdd:cd00202      1 ACSNCGTTTTPLWRRGPSGGsTLCNACGLYWKKHGVMRPLS--KRKKDQ--IKRRNRK 54
 
Name Accession Description Interval E-value
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 895-951 3.97e-14

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 67.78  E-value: 3.97e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1060099343  895 FCANCLTTKTSLWRKNANGG-YVCNACGLYQKLHSTPRPLNiiKQNNGEqiIRRRTRK 951
Cdd:cd00202      1 ACSNCGTTTTPLWRRGPSGGsTLCNACGLYWKKHGVMRPLS--KRKKDQ--IKRRNRK 54
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 896-930 5.63e-12

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 61.18  E-value: 5.63e-12
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1060099343  896 CANCLTTKTSLWRKNANGGY-VCNACGLYQKLHSTP 930
Cdd:pfam00320    1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKKGLK 36
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
891-934 9.94e-12

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 60.89  E-value: 9.94e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 1060099343   891 GSGVFCANCLTTKTSLWRKNANG-GYVCNACGLYQKLHSTP-RPLN 934
Cdd:smart00401    1 GSGRSCSNCGTTETPLWRRGPSGnKTLCNACGLYYKKHGGLkRPLS 46
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
872-960 7.51e-07

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 53.34  E-value: 7.51e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060099343  872 ASGENKSKDESQSllrrrrgsgVFCANCLTTKTSLWRK-----NANGGYVCNACGLYQKLHSTPRPLNIIKQNNGEQIIR 946
Cdd:COG5641    146 NPNNNQSDNSNQP---------HVCSNCKTTSTPLWRRassesSLPGNNLCNACGLYLKLHGSPRAPISLKSDSIKSRSS 216

                           90
                   ....*....|....
gi 1060099343  947 RRTRKRLNPEALQA 960
Cdd:COG5641    217 RSSHNNNDSNGENA 230
 
Name Accession Description Interval E-value
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 895-951 3.97e-14

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 67.78  E-value: 3.97e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1060099343  895 FCANCLTTKTSLWRKNANGG-YVCNACGLYQKLHSTPRPLNiiKQNNGEqiIRRRTRK 951
Cdd:cd00202      1 ACSNCGTTTTPLWRRGPSGGsTLCNACGLYWKKHGVMRPLS--KRKKDQ--IKRRNRK 54
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 896-930 5.63e-12

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 61.18  E-value: 5.63e-12
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1060099343  896 CANCLTTKTSLWRKNANGGY-VCNACGLYQKLHSTP 930
Cdd:pfam00320    1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKKGLK 36
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
891-934 9.94e-12

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 60.89  E-value: 9.94e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 1060099343   891 GSGVFCANCLTTKTSLWRKNANG-GYVCNACGLYQKLHSTP-RPLN 934
Cdd:smart00401    1 GSGRSCSNCGTTETPLWRRGPSGnKTLCNACGLYYKKHGGLkRPLS 46
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
872-960 7.51e-07

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 53.34  E-value: 7.51e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060099343  872 ASGENKSKDESQSllrrrrgsgVFCANCLTTKTSLWRK-----NANGGYVCNACGLYQKLHSTPRPLNIIKQNNGEQIIR 946
Cdd:COG5641    146 NPNNNQSDNSNQP---------HVCSNCKTTSTPLWRRassesSLPGNNLCNACGLYLKLHGSPRAPISLKSDSIKSRSS 216

                           90
                   ....*....|....
gi 1060099343  947 RRTRKRLNPEALQA 960
Cdd:COG5641    217 RSSHNNNDSNGENA 230
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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