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Conserved domains on  [gi|1060597009|ref|XP_017809788|]
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ankyrin repeat and SOCS box protein 9 isoform X3 [Papio anubis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
36-217 6.09e-31

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 116.21  E-value: 6.09e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060597009  36 DWSPMHEAAIYGHQLSLRNLISQ---VNGVTTDWHTPLFNACVSGSRDCVNLLLQHGASV-QPESDLASPIHEAARRGHV 111
Cdd:COG0666    87 GNTLLHAAARNGDLEIVKLLLEAgadVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVnAQDNDGNTPLHLAAANGNL 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060597009 112 ECVDSLIAYGSNIDHKISHLGTPLYLACENQQRACVKKLLESGADVN-QGKGQDSPLHAVARTASEELACLLMDFGADTQ 190
Cdd:COG0666   167 EIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNaKDNDGKTALDLAAENGNLEIVKLLLEAGADLN 246

                         170       180
                  ....*....|....*....|....*..
gi 1060597009 191 AKNAEGKRPVELVPPDSPLARLFLERE 217
Cdd:COG0666   247 AKDKDGLTALLLAAAAGAALIVKLLLL 273
SOCS_ASB_9_11 cd03728
SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have ...
 217-258 1.18e-19

SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


:

Pssm-ID: 239698  Cd Length: 42  Bit Score: 79.45  E-value: 1.18e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1060597009 217 EGPPSLMQLCRLRIRKCFGIQQHHKITKLVLPEDLKQFLLHL 258
Cdd:cd03728     1 EGPPSLMQLCRLCIRKCFGRKQHHKIHKLHLPEPLKHFLLYR 42
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
36-217 6.09e-31

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 116.21  E-value: 6.09e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060597009  36 DWSPMHEAAIYGHQLSLRNLISQ---VNGVTTDWHTPLFNACVSGSRDCVNLLLQHGASV-QPESDLASPIHEAARRGHV 111
Cdd:COG0666    87 GNTLLHAAARNGDLEIVKLLLEAgadVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVnAQDNDGNTPLHLAAANGNL 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060597009 112 ECVDSLIAYGSNIDHKISHLGTPLYLACENQQRACVKKLLESGADVN-QGKGQDSPLHAVARTASEELACLLMDFGADTQ 190
Cdd:COG0666   167 EIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNaKDNDGKTALDLAAENGNLEIVKLLLEAGADLN 246

                         170       180
                  ....*....|....*....|....*..
gi 1060597009 191 AKNAEGKRPVELVPPDSPLARLFLERE 217
Cdd:COG0666   247 AKDKDGLTALLLAAAAGAALIVKLLLL 273
SOCS_ASB_9_11 cd03728
SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have ...
 217-258 1.18e-19

SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239698  Cd Length: 42  Bit Score: 79.45  E-value: 1.18e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1060597009 217 EGPPSLMQLCRLRIRKCFGIQQHHKITKLVLPEDLKQFLLHL 258
Cdd:cd03728     1 EGPPSLMQLCRLCIRKCFGRKQHHKIHKLHLPEPLKHFLLYR 42
Ank_2 pfam12796
Ankyrin repeats (3 copies);
102-193 1.24e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 67.45  E-value: 1.24e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060597009 102 IHEAARRGHVECVDSLIAYGSNIDHKISHLGTPLYLACENQQRACVKKLLESgADVNQGKGQDSPLHAVARTASEELACL 181
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGRTALHYAARSGHLEIVKL 79

                          90
                  ....*....|..
gi 1060597009 182 LMDFGADTQAKN 193
Cdd:pfam12796  80 LLEKGADINVKD 91
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 38-200 1.98e-14

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 72.40  E-value: 1.98e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060597009  38 SPMHEAAIYGHQL-SLRNLISQ---VNGVTTDWHTPLFNA-CVSGSRDCVNLLLQHGASVQPESDL-ASPIHEAARRGHV 111
Cdd:PHA02876  309 TPLYLMAKNGYDTeNIRTLIMLgadVNAADRLYITPLHQAsTLDRNKDIVITLLELGANVNARDYCdKTPIHYAAVRNNV 388

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060597009 112 ECVDSLIAYGSNIDHKISHLGTPLYLA-CENQQRACVKKLLESGADVN-QGKGQDSPLH-AVARTASEELACLLMDFGAD 188
Cdd:PHA02876  389 VIINTLLDYGADIEALSQKIGTALHFAlCGTNPYMSVKTLIDRGANVNsKNKDLSTPLHyACKKNCKLDVIEMLLDNGAD 468

                         170
                  ....*....|..
gi 1060597009 189 TQAKNAEGKRPV 200
Cdd:PHA02876  469 VNAINIQNQYPL 480
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 218-256 2.45e-10

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 54.48  E-value: 2.45e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1060597009 218 GPPSLMQLCRLRIRKCFGIQQHHKITKLVLPEDLKQFLL 256
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRRLGAIDKLPLPPLLKDYLL 39
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 220-257 5.05e-07

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 45.09  E-value: 5.05e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1060597009  220 PSLMQLCRLRIRKCFGiqqhhKITKLVLPEDLKQFLLH 257
Cdd:smart00969   1 RSLQHLCRLAIRRSLG-----GIDKLPLPPRLKDYLLY 33
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 57-191 9.85e-06

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 46.23  E-value: 9.85e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060597009  57 SQVNGVTTDWHTPLFNACVSGS-RDCVNLLLQHGASVQPESDLaspIHeAARRGHVECVDSLIAYGSNIDHKISHLG--- 132
Cdd:TIGR00870  43 LNINCPDRLGRSALFVAAIENEnLELTELLLNLSCRGAVGDTL---LH-AISLEYVDAVEAILLHLLAAFRKSGPLElan 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060597009 133 -----------TPLYLACENQQRACVKKLLESGADVN---------QGKGQD------SPLHAVARTASEELACLLMDFG 186
Cdd:TIGR00870 119 dqytseftpgiTALHLAAHRQNYEIVKLLLERGASVParacgdffvKSQGVDsfyhgeSPLNAAACLGSPSIVALLSEDP 198


                  ....*
gi 1060597009 187 ADTQA 191
Cdd:TIGR00870 199 ADILT 203
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 133-158 4.80e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.80  E-value: 4.80e-04
                           10        20
                   ....*....|....*....|....*.
gi 1060597009  133 TPLYLACENQQRACVKKLLESGADVN 158
Cdd:smart00248   4 TPLHLAAENGNLEVVKLLLDKGADIN 29
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 40-185 1.27e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 39.61  E-value: 1.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060597009  40 MHEAAIYGH-QLSL------RNLISQVngVTTDWH---TPLFNACVSGSRDCVNLLLQHGASVQpeSDLASPIheAARRG 109
Cdd:cd22192    55 LHVAALYDNlEAAVvlmeaaPELVNEP--MTSDLYqgeTALHIAVVNQNLNLVRELIARGADVV--SPRATGT--FFRPG 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060597009 110 hvecVDSLIAYGsniDHKIShlgtplYLACENQQRAcVKKLLESGADVnqgKGQDS----PLHAVARTASEELACLLMDF 185
Cdd:cd22192   129 ----PKNLIYYG---EHPLS------FAACVGNEEI-VRLLIEHGADI---RAQDSlgntVLHILVLQPNKTFACQMYDL 191
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
36-217 6.09e-31

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 116.21  E-value: 6.09e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060597009  36 DWSPMHEAAIYGHQLSLRNLISQ---VNGVTTDWHTPLFNACVSGSRDCVNLLLQHGASV-QPESDLASPIHEAARRGHV 111
Cdd:COG0666    87 GNTLLHAAARNGDLEIVKLLLEAgadVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVnAQDNDGNTPLHLAAANGNL 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060597009 112 ECVDSLIAYGSNIDHKISHLGTPLYLACENQQRACVKKLLESGADVN-QGKGQDSPLHAVARTASEELACLLMDFGADTQ 190
Cdd:COG0666   167 EIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNaKDNDGKTALDLAAENGNLEIVKLLLEAGADLN 246

                         170       180
                  ....*....|....*....|....*..
gi 1060597009 191 AKNAEGKRPVELVPPDSPLARLFLERE 217
Cdd:COG0666   247 AKDKDGLTALLLAAAAGAALIVKLLLL 273
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
22-258 2.06e-30

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 114.67  E-value: 2.06e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060597009  22 IRLLSNPLMSDAVSDWSPMHEAAIYGHQLSLRNLISQ---VNGVTTDWHTPLFNACVSGSRDCVNLLLQHGASV-QPESD 97
Cdd:COG0666    40 LLLALLALALADALGALLLLAAALAGDLLVALLLLAAgadINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVnARDKD 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060597009  98 LASPIHEAARRGHVECVDSLIAYGSNIDHKISHLGTPLYLACENQQRACVKKLLESGADVN-QGKGQDSPLHAVARTASE 176
Cdd:COG0666   120 GETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNaRDNDGETPLHLAAENGHL 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060597009 177 ELACLLMDFGADTQAKNAEGKRPVEL--VPPDSPLARLFLEREGPPSLMQLCRLRIRKCFGIQQHHKITKLVLPEDLKQF 254
Cdd:COG0666   200 EIVKLLLEAGADVNAKDNDGKTALDLaaENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLA 279


                  ....
gi 1060597009 255 LLHL 258
Cdd:COG0666   280 AALL 283
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
50-199 3.62e-22

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 92.71  E-value: 3.62e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060597009  50 LSLRNLISQVNGVTTDWHTPLFNACVSGSRDCVNLLLQHGASV-QPESDLASPIHEAARRGHVECVDSLIAYGSNIDHKI 128
Cdd:COG0666    38 LLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADInAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARD 117

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1060597009 129 SHLGTPLYLACENQQRACVKKLLESGADVN-QGKGQDSPLHAVARTASEELACLLMDFGADTQAKNAEGKRP 199
Cdd:COG0666   118 KDGETPLHLAAYNGNLEIVKLLLEAGADVNaQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETP 189
SOCS_ASB_9_11 cd03728
SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have ...
 217-258 1.18e-19

SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239698  Cd Length: 42  Bit Score: 79.45  E-value: 1.18e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1060597009 217 EGPPSLMQLCRLRIRKCFGIQQHHKITKLVLPEDLKQFLLHL 258
Cdd:cd03728     1 EGPPSLMQLCRLCIRKCFGRKQHHKIHKLHLPEPLKHFLLYR 42
Ank_2 pfam12796
Ankyrin repeats (3 copies);
102-193 1.24e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 67.45  E-value: 1.24e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060597009 102 IHEAARRGHVECVDSLIAYGSNIDHKISHLGTPLYLACENQQRACVKKLLESgADVNQGKGQDSPLHAVARTASEELACL 181
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGRTALHYAARSGHLEIVKL 79

                          90
                  ....*....|..
gi 1060597009 182 LMDFGADTQAKN 193
Cdd:pfam12796  80 LLEKGADINVKD 91
SOCS_ASB_like cd03716
SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB ...
 217-257 1.64e-14

SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable number of repeats. SSB proteins contain a central SPRY domain and a C-terminal SOCS. Recently, it has been shown that all four SSB proteins interact with the MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), and that SSB-1, SSB-2, and SSB-4 interact with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain.


Pssm-ID: 239686  Cd Length: 42  Bit Score: 65.59  E-value: 1.64e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1060597009 217 EGPPSLMQLCRLRIRKCFGIQQHHKITKLVLPEDLKQFLLH 257
Cdd:cd03716     1 STPRSLQHLCRLAIRRCLGRRRLELIKKLPLPPRLKDYLLY 41
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 38-200 1.98e-14

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 72.40  E-value: 1.98e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060597009  38 SPMHEAAIYGHQL-SLRNLISQ---VNGVTTDWHTPLFNA-CVSGSRDCVNLLLQHGASVQPESDL-ASPIHEAARRGHV 111
Cdd:PHA02876  309 TPLYLMAKNGYDTeNIRTLIMLgadVNAADRLYITPLHQAsTLDRNKDIVITLLELGANVNARDYCdKTPIHYAAVRNNV 388

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060597009 112 ECVDSLIAYGSNIDHKISHLGTPLYLA-CENQQRACVKKLLESGADVN-QGKGQDSPLH-AVARTASEELACLLMDFGAD 188
Cdd:PHA02876  389 VIINTLLDYGADIEALSQKIGTALHFAlCGTNPYMSVKTLIDRGANVNsKNKDLSTPLHyACKKNCKLDVIEMLLDNGAD 468

                         170
                  ....*....|..
gi 1060597009 189 TQAKNAEGKRPV 200
Cdd:PHA02876  469 VNAINIQNQYPL 480
Ank_2 pfam12796
Ankyrin repeats (3 copies);
40-127 1.93e-13

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 64.37  E-value: 1.93e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060597009  40 MHEAAIYGHQLSLRNLI---SQVNGVTTDWHTPLFNACVSGSRDCVNLLLQHgASVQPESDLASPIHEAARRGHVECVDS 116
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLengADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGRTALHYAARSGHLEIVKL 79

                          90
                  ....*....|.
gi 1060597009 117 LIAYGSNIDHK 127
Cdd:pfam12796  80 LLEKGADINVK 90
SOCS cd03587
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 219-257 4.63e-13

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239641  Cd Length: 41  Bit Score: 61.72  E-value: 4.63e-13
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1060597009 219 PPSLMQLCRLRIRKCFGIQQHHKITKLVLPEDLKQFLLH 257
Cdd:cd03587     2 PRSLQHLCRLAIRRCLGKRRLDLIDKLPLPPRLKDYLLY 40
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 57-203 3.58e-12

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 65.67  E-value: 3.58e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060597009  57 SQVNGVTTDW-HTPLFNACVSGSRDCVNLLLQHGASVQ-PESDLASPIHEAARRGHVECVDSLIAYGSNIDHKISHLGTP 134
Cdd:PHA02878  158 ADINMKDRHKgNTALHYATENKDQRLTELLLSYGANVNiPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTP 237

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1060597009 135 LYLA---CENQQraCVKKLLESGADVNQGKG--QDSPLHAVARtaSEELACLLMDFGADTQAKNAEGKRPVELV 203
Cdd:PHA02878  238 LHISvgyCKDYD--ILKLLLEHGVDVNAKSYilGLTALHSSIK--SERKLKLLLEYGADINSLNSYKLTPLSSA 307
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 218-256 2.45e-10

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 54.48  E-value: 2.45e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1060597009 218 GPPSLMQLCRLRIRKCFGIQQHHKITKLVLPEDLKQFLL 256
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRRLGAIDKLPLPPLLKDYLL 39
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 68-194 1.03e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 55.06  E-value: 1.03e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060597009  68 TPLFNACV--SGSRDCVNLLLQHGASVQP-ESDLASPIHEAARRGHVEC------------------VDSLIAYGSNIDH 126
Cdd:PHA03100  108 TPLLYAISkkSNSYSIVEYLLDNGANVNIkNSDGENLLHLYLESNKIDLkilkllidkgvdinaknrVNYLLSYGVPINI 187

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060597009 127 KISHLGTPLYLACENQQRACVKKLLESGADVN--QGKGqDSPLHAVARTASEELACLLMDFGADTQAKNA 194
Cdd:PHA03100  188 KDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNlvNKYG-DTPLHIAILNNNKEIFKLLLNNGPSIKTIIE 256
Ank_2 pfam12796
Ankyrin repeats (3 copies);
37-92 3.01e-08

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 50.11  E-value: 3.01e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1060597009  37 WSPMHEAAIYGHQLSLRNLISQVNG-VTTDWHTPLFNACVSGSRDCVNLLLQHGASV 92
Cdd:pfam12796  31 RTALHLAAKNGHLEIVKLLLEHADVnLKDNGRTALHYAARSGHLEIVKLLLEKGADI 87
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 38-189 1.10e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 51.92  E-value: 1.10e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060597009  38 SPMHEAAIYGHQLSLRNLI---SQVNGVT-TDWHTPLFNACVSGSRDCVNLLLQHGASVQ-PESDLASPIHEAARRGHVE 112
Cdd:PHA02875   70 SELHDAVEEGDVKAVEELLdlgKFADDVFyKDGMTPLHLATILKKLDIMKLLIARGADPDiPNTDKFSPLHLAVMMGDIK 149

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1060597009 113 CVDSLIAYGSNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQ-GKGQDSPLHAVA-RTASEELACLLMDFGADT 189
Cdd:PHA02875  150 GIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYfGKNGCVAALCYAiENNKIDIVRLFIKRGADC 228
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 57-200 1.14e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 51.89  E-value: 1.14e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060597009  57 SQVNGVTTDWHTPLFNACVSGSRDCVNLLLQHG--ASVQPESDLASP----------------------IHEAARRGHVE 112
Cdd:PHA02874   59 ADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGvdTSILPIPCIEKDmiktildcgidvnikdaelktfLHYAIKKGDLE 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060597009 113 CVDSLIAYGSNIDHKISHLGTPLYLACENQQRACVKKLLESGA--DVNQGKGqDSPLHAVARTASEELACLLMDFGADTQ 190
Cdd:PHA02874  139 SIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAyaNVKDNNG-ESPLHNAAEYGDYACIKLLIDHGNHIM 217

                         170
                  ....*....|
gi 1060597009 191 AKNAEGKRPV 200
Cdd:PHA02874  218 NKCKNGFTPL 227
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 220-257 5.05e-07

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 45.09  E-value: 5.05e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1060597009  220 PSLMQLCRLRIRKCFGiqqhhKITKLVLPEDLKQFLLH 257
Cdd:smart00969   1 RSLQHLCRLAIRRSLG-----GIDKLPLPPRLKDYLLY 33
PHA03095 PHA03095
ankyrin-like protein; Provisional
 82-200 5.19e-07

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 50.02  E-value: 5.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060597009  82 VNLLLQHGASVQPESDLAS-PIHEAARRGHVEC---VDSLIAYGSNIDHKISHLGTPLYLACENQQRACVKKLL-ESGAD 156
Cdd:PHA03095   30 VRRLLAAGADVNFRGEYGKtPLHLYLHYSSEKVkdiVRLLLEAGADVNAPERCGFTPLHLYLYNATTLDVIKLLiKAGAD 109

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1060597009 157 VN-QGKGQDSPLHAVARTAS--EELACLLMDFGADTQAKNAEGKRPV 200
Cdd:PHA03095  110 VNaKDKVGRTPLHVYLSGFNinPKVIRLLLRKGADVNALDLYGMTPL 156
PHA03095 PHA03095
ankyrin-like protein; Provisional
 111-199 5.59e-07

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 50.02  E-value: 5.59e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060597009 111 VECVDSLIAYGSNIDHKISHLGTPL--YLACENQQRA-CVKKLLESGADVN-QGKGQDSPLHAVARTASEE-LACLLMDF 185
Cdd:PHA03095   27 VEEVRRLLAAGADVNFRGEYGKTPLhlYLHYSSEKVKdIVRLLLEAGADVNaPERCGFTPLHLYLYNATTLdVIKLLIKA 106

                          90
                  ....*....|....
gi 1060597009 186 GADTQAKNAEGKRP 199
Cdd:PHA03095  107 GADVNAKDKVGRTP 120
Ank_4 pfam13637
Ankyrin repeats (many copies);
100-151 6.81e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 45.34  E-value: 6.81e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1060597009 100 SPIHEAARRGHVECVDSLIAYGSNIDHKISHLGTPLYLACENQQRACVKKLL 151
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
SOCS_ASB1 cd03720
SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a ...
 219-257 9.21e-07

SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239690  Cd Length: 42  Bit Score: 44.72  E-value: 9.21e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1060597009 219 PPSLMQLCRLRIRKCFGIQQHHKITKLVLPEDLKQFLLH 257
Cdd:cd03720     3 PRSLLSLCRIAVRRALGKQRLSLICSLPLPDPIKKFLLH 41
SOCS_ASB5 cd03724
SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a ...
 219-255 1.36e-06

SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB5 has been implicated in the initiation of arteriogenesis. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239694  Cd Length: 42  Bit Score: 44.10  E-value: 1.36e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1060597009 219 PPSLMQLCRLRIRKCFGIQQHHKITKLVLPEDLKQFL 255
Cdd:cd03724     3 PSSLCQLCRLCIRNYIGRSRLHLIPQLQLPTLLKNFL 39
Ank_4 pfam13637
Ankyrin repeats (many copies);
66-118 1.54e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 44.19  E-value: 1.54e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1060597009  66 WHTPLFNACVSGSRDCVNLLLQHGASV--QPESDLaSPIHEAARRGHVECVDSLI 118
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADInaVDGNGE-TALHFAASNGNVEVLKLLL 54
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 69-201 2.02e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 48.42  E-value: 2.02e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060597009  69 PLFNACVSGSRDCVNLLLQHGASVQ-PESDLASPIHEAARRGHVECVDSLIAYGSNIDHKISHLGTPLYLACENQQRACv 147
Cdd:PHA02874  160 PIHIAIKHNFFDIIKLLLEKGAYANvKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNRSAI- 238

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1060597009 148 kKLLESGADVN-QGKGQDSPLH-AVARTASEELACLLMDFGADTQAKNAEGKRPVE 201
Cdd:PHA02874  239 -ELLINNASINdQDIDGSTPLHhAINPPCDIDIIDILLYHKADISIKDNKGENPID 293
SOCS_ASB13 cd03729
SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a ...
 219-258 6.43e-06

SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239699  Cd Length: 42  Bit Score: 42.08  E-value: 6.43e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1060597009 219 PPSLMQLCRLRIRKCFGIQQHHKITKLVLPEDLKQFLLHL 258
Cdd:cd03729     3 PLSLQQLCRINLRKALGTRALEKIAKLNIPNRIIDYLSYN 42
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 68-203 8.33e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 46.60  E-value: 8.33e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060597009  68 TPLFNACVSGSRDCVNLLLQHGASVQPES-DLASPIHEAARRGHVECVDSLIAYGSNIDHKishlGTPLYLACENQQRAC 146
Cdd:PHA02876  180 TPIHYAAERGNAKMVNLLLSYGADVNIIAlDDLSVLECAVDSKNIDTIKAIIDNRSNINKN----DLSLLKAIRNEDLET 255

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1060597009 147 VKKLLESGADVNQ-GKGQDSPLHAVARTAS-EELACLLMDFGADTQAKNAEGKRPVELV 203
Cdd:PHA02876  256 SLLLYDAGFSVNSiDDCKNTPLHHASQAPSlSRLVPKLLERGADVNAKNIKGETPLYLM 314
SOCS_ASB2 cd03721
SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a ...
 217-257 9.43e-06

SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB2 targets specific proteins to destruction by the proteasome in leukemia cells that have been induced to differentiate. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239691  Cd Length: 45  Bit Score: 41.77  E-value: 9.43e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1060597009 217 EGPPSLMQLCRLRIRKCFGIQQHHKITKLVLPEDLKQFLLH 257
Cdd:cd03721     1 EPPRPLAHLCRLKVRTLIGINRIKLIDTLPLPPRLIRYLNH 41
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 57-191 9.85e-06

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 46.23  E-value: 9.85e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060597009  57 SQVNGVTTDWHTPLFNACVSGS-RDCVNLLLQHGASVQPESDLaspIHeAARRGHVECVDSLIAYGSNIDHKISHLG--- 132
Cdd:TIGR00870  43 LNINCPDRLGRSALFVAAIENEnLELTELLLNLSCRGAVGDTL---LH-AISLEYVDAVEAILLHLLAAFRKSGPLElan 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060597009 133 -----------TPLYLACENQQRACVKKLLESGADVN---------QGKGQD------SPLHAVARTASEELACLLMDFG 186
Cdd:TIGR00870 119 dqytseftpgiTALHLAAHRQNYEIVKLLLERGASVParacgdffvKSQGVDsfyhgeSPLNAAACLGSPSIVALLSEDP 198


                  ....*
gi 1060597009 187 ADTQA 191
Cdd:TIGR00870 199 ADILT 203
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 70-202 1.01e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 46.14  E-value: 1.01e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060597009  70 LFNACVSGSRDCVNLLLQHGasVQPESDLA---SPIHEAARRGHVECVDSLIAYGSNIDHKISHLGTPLYLACENQQRAC 146
Cdd:PHA02875    6 LCDAILFGELDIARRLLDIG--INPNFEIYdgiSPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKA 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1060597009 147 VKKLLESGA---DVNQGKGqDSPLHAVARTASEELACLLMDFGADTQAKNAEGKRPVEL 202
Cdd:PHA02875   84 VEELLDLGKfadDVFYKDG-MTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHL 141
SOCS_SOCS_like cd03717
SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of ...
 217-256 1.04e-05

SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. These intracellular proteins regulate the responses of immune cells to cytokines. Identified as negative regulators of the cytokine-JAK-STAT pathway, they seem to play a role in many immunological and pathological processes. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. Related SOCS boxes are also present in Rab40-like proteins and insect proteins of unknown function that also contain a NEUZ (domain in neuralized proteins) domain.


Pssm-ID: 239687  Cd Length: 39  Bit Score: 41.43  E-value: 1.04e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1060597009 217 EGPPSLMQLCRLRIRKCFGIqqhHKITKLVLPEDLKQFLL 256
Cdd:cd03717     1 TSVRSLQHLCRFVIRQCTRR---DLIDQLPLPRRLKDYLK 37
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 45-202 1.49e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 45.72  E-value: 1.49e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060597009  45 IYGHQLSL-RNLISQ----VNGVTTDWHTPLFNACVSGSRDCVNLLLQHGASV-QPESDLASPIHEAARRGHVECVDSLI 118
Cdd:PHA02874    9 IYSGDIEAiEKIIKNkgncINISVDETTTPLIDAIRSGDAKIVELFIKHGADInHINTKIPHPLLTAIKIGAHDIIKLLI 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060597009 119 AYGsnIDHKIshlgtpLYLACENQQraCVKKLLESGADVN-QGKGQDSPLHAVARTASEELACLLMDFGADTQAKNAEGK 197
Cdd:PHA02874   89 DNG--VDTSI------LPIPCIEKD--MIKTILDCGIDVNiKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGC 158


                  ....*
gi 1060597009 198 RPVEL 202
Cdd:PHA02874  159 YPIHI 163
SOCS_ASB4_ASB18 cd03723
SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members ...
 219-256 1.61e-05

SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239693  Cd Length: 48  Bit Score: 41.27  E-value: 1.61e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1060597009 219 PPSLMQLCRLRIRKCFGIQQHHKITKLVLPEDLKQFLL 256
Cdd:cd03723     3 PRSLQHLCRCAIRKLLGSRCHKLVPQLSLPTSLKNYLL 40
SOCS_SSB1_4 cd03718
SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box ...
 219-257 2.29e-05

SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF) and also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239688  Cd Length: 42  Bit Score: 40.75  E-value: 2.29e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1060597009 219 PPSLMQLCRLRIRKCFGIQQHHKITKLVLPEDLKQFLLH 257
Cdd:cd03718     3 PLPLMDLCRRRVRVALGRDRLEEIEQLPLPPSLKNYLLY 41
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 38-157 2.69e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 45.24  E-value: 2.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060597009  38 SPMHEAAIYGHQ---LSLRNLISQVNGVTTDWHTPLFNACVSGSRDCVNLLLQHGASVQPES--DLaspIHEAARRGHVE 112
Cdd:PLN03192  560 TPLHIAASKGYEdcvLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILYHFASISDPHAagDL---LCTAAKRNDLT 636

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1060597009 113 CVDSLIAYGSNIDHKISHLGTPLYLACENQQRACVKKLLESGADV 157
Cdd:PLN03192  637 AMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADV 681
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 68-131 3.04e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 44.66  E-value: 3.04e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1060597009  68 TPLFNACVSGSRDCVNLLLQHGASVQPESDLA-SPIHEAARRGHVECVDSLIAYGSNIDHKISHL 131
Cdd:PHA03100  194 TPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGdTPLHIAILNNNKEIFKLLLNNGPSIKTIIETL 258
PHA02884 PHA02884
ankyrin repeat protein; Provisional
 68-148 2.82e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165212 [Multi-domain]  Cd Length: 300  Bit Score: 41.51  E-value: 2.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060597009  68 TPLFNACVSGSRDCVNLLLQHGASVQPESDLA--SPIHEAARRGHVECVDSLIAYGSNIDHKISHLGTPLYLA---CENQ 142
Cdd:PHA02884   72 NPLIYAIDCDNDDAAKLLIRYGADVNRYAEEAkiTPLYISVLHGCLKCLEILLSYGADINIQTNDMVTPIELAlmiCNNF 151


                  ....*.
gi 1060597009 143 QRACVK 148
Cdd:PHA02884  152 LAFMIC 157
SOCS_SSB4 cd03743
SOCS (suppressors of cytokine signaling) box of SSB4 (SPRY domain-containing SOCS box ...
 219-255 3.28e-04

SOCS (suppressors of cytokine signaling) box of SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF). SSB4, like SSB2 and SSB1, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239712  Cd Length: 42  Bit Score: 37.63  E-value: 3.28e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1060597009 219 PPSLMQLCRLRIRKCFGIQQHHKITKLVLPEDLKQFL 255
Cdd:cd03743     3 PLPLMDLCRRSARQALGRHRLHHIQSLPLPQTLKNYL 39
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 38-158 4.48e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 41.13  E-value: 4.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060597009  38 SPMHEAAIYGHQLSLRNLI---SQVNGVTTDWHTPLFNACVSGSRDCVNLLLQHGASVQPESDLA-SPIHEAARRGHVEC 113
Cdd:PHA02875  104 TPLHLATILKKLDIMKLLIargADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGcTPLIIAMAKGDIAI 183

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1060597009 114 VDSLIAYGSNIDHkISHLG--TPLYLACENQQRACVKKLLESGADVN 158
Cdd:PHA02875  184 CKMLLDSGANIDY-FGKNGcvAALCYAIENNKIDIVRLFIKRGADCN 229
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 133-158 4.80e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.80  E-value: 4.80e-04
                           10        20
                   ....*....|....*....|....*.
gi 1060597009  133 TPLYLACENQQRACVKKLLESGADVN 158
Cdd:smart00248   4 TPLHLAAENGNLEVVKLLLDKGADIN 29
SOCS smart00253
suppressors of cytokine signalling; suppressors of cytokine signalling
 216-256 5.05e-04

suppressors of cytokine signalling; suppressors of cytokine signalling


Pssm-ID: 128549  Cd Length: 43  Bit Score: 36.89  E-value: 5.05e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1060597009  216 REGPPSLMQLCRLRIRKCFGIQQhhkITKLVLPEDLKQFLL 256
Cdd:smart00253   4 PSNVPSLQHLCRFTIRRCTRTDQ---IKTLPLPPKLKDYLS 41
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 40-185 1.27e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 39.61  E-value: 1.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060597009  40 MHEAAIYGH-QLSL------RNLISQVngVTTDWH---TPLFNACVSGSRDCVNLLLQHGASVQpeSDLASPIheAARRG 109
Cdd:cd22192    55 LHVAALYDNlEAAVvlmeaaPELVNEP--MTSDLYqgeTALHIAVVNQNLNLVRELIARGADVV--SPRATGT--FFRPG 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060597009 110 hvecVDSLIAYGsniDHKIShlgtplYLACENQQRAcVKKLLESGADVnqgKGQDS----PLHAVARTASEELACLLMDF 185
Cdd:cd22192   129 ----PKNLIYYG---EHPLS------FAACVGNEEI-VRLLIEHGADI---RAQDSlgntVLHILVLQPNKTFACQMYDL 191
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 38-200 1.30e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 39.66  E-value: 1.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060597009  38 SPMHEAAIYGHQLSLRNLIS---QVNGVTTDWHTPLFNACVSGSRDCVN-----------------------------LL 85
Cdd:PHA02876  180 TPIHYAAERGNAKMVNLLLSygaDVNIIALDDLSVLECAVDSKNIDTIKaiidnrsninkndlsllkairnedletslLL 259

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060597009  86 LQHGASVQPESDLA-SPIHEAARRGHV-ECVDSLIAYGSNIDHKISHLGTPLYLACEN-QQRACVKKLLESGADVNQGKG 162
Cdd:PHA02876  260 YDAGFSVNSIDDCKnTPLHHASQAPSLsRLVPKLLERGADVNAKNIKGETPLYLMAKNgYDTENIRTLIMLGADVNAADR 339

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1060597009 163 Q-DSPLH-AVARTASEELACLLMDFGADTQAKNAEGKRPV 200
Cdd:PHA02876  340 LyITPLHqASTLDRNKDIVITLLELGANVNARDYCDKTPI 379
SOCS_ASB15 cd03731
SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a ...
 217-257 2.56e-03

SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB15 is expressed predominantly in skeletal muscle and participates in the regulation of protein turnover and muscle cell development by stimulating protein synthesis and regulating differentiation of muscle cells. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239701  Cd Length: 56  Bit Score: 35.19  E-value: 2.56e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1060597009 217 EGPPSLMQLCRLRIRKCFGIQQHHK---ITKLVLPEDLKQFLLH 257
Cdd:cd03731     1 ENPRPLKHLCRLKIRKLMGLQKLQQpssMKKLPLPPALKRYILY 44
SOCS_SSB1 cd03744
SOCS (suppressors of cytokine signaling) box of SSB1 (SPRY domain-containing SOCS box proteins) ...
 219-257 2.96e-03

SOCS (suppressors of cytokine signaling) box of SSB1 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), both the absence and the presence of HGF and enhances the HGF-MET-induced mitogen-activated protein kinases Erk-transcription factor Elk-1-serum response elements (SRE) pathway. SSB1, like SSB2 and SSB4, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239713  Cd Length: 42  Bit Score: 34.96  E-value: 2.96e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1060597009 219 PPSLMQLCRLRIRKCFGIQQHHKITKLVLPEDLKQFLLH 257
Cdd:cd03744     3 PLPLMDLCRRSVRLALGRERLSEIHTLPLPASLKNYLLY 41
SOCS_ASB7 cd03726
SOCS (suppressors of cytokine signaling) box of ASB7-like proteins. ASB family members have a ...
 219-257 3.05e-03

SOCS (suppressors of cytokine signaling) box of ASB7-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239696  Cd Length: 45  Bit Score: 34.82  E-value: 3.05e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1060597009 219 PPSLMQLCRLRIRKCFGIQQHHKITKLVLPEDLKQFLLH 257
Cdd:cd03726     3 PRTLQDLCRIKIRHCIGLQNLKLLDELPIAKVMKDYLKH 41
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 66-200 3.23e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 38.46  E-value: 3.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060597009  66 WHTPLFNACVSGSRDCVN-LLLQHGASVQPESDLA-SPIHEAARRGHVECVDSLI-AYGSNIDHKIS---HLG-TPLYLA 138
Cdd:cd22192    17 SESPLLLAAKENDVQAIKkLLKCPSCDLFQRGALGeTALHVAALYDNLEAAVVLMeAAPELVNEPMTsdlYQGeTALHIA 96

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1060597009 139 CENQQRACVKKLLESGADVNQG--------KGQDS-------PLHAVARTASEELACLLMDFGADTQAKNAEGKRPV 200
Cdd:cd22192    97 VVNQNLNLVRELIARGADVVSPratgtffrPGPKNliyygehPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVL 173
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 124-199 3.30e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 38.49  E-value: 3.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060597009 124 IDHKISHLGTPLYLACENQQRACVKKLLESGADVNQ-GKGQDSPLHAVAR-----TASEELACLLMDFGADTQAKNAEGK 197
Cdd:PHA03100   28 NDYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSsTKNNSTPLHYLSNikynlTDVKEIVKLLLEYGANVNAPDNNGI 107


                  ..
gi 1060597009 198 RP 199
Cdd:PHA03100  108 TP 109
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 65-92 3.31e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.49  E-value: 3.31e-03
                           10        20
                   ....*....|....*....|....*...
gi 1060597009   65 DWHTPLFNACVSGSRDCVNLLLQHGASV 92
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADI 28
SOCS_ASB14 cd03730
SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a ...
 217-257 3.52e-03

SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239700  Cd Length: 57  Bit Score: 34.82  E-value: 3.52e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1060597009 217 EGPPSLMQLCRLRIRKCFG---IQQHHKITKLVLPEDLKQFLLH 257
Cdd:cd03730     1 TNPRSLKHLCRLKIRACMGrlrLRCPVFMSFLPLPNRLKAYILY 44
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 100-125 4.14e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.10  E-value: 4.14e-03
                           10        20
                   ....*....|....*....|....*.
gi 1060597009  100 SPIHEAARRGHVECVDSLIAYGSNID 125
Cdd:smart00248   4 TPLHLAAENGNLEVVKLLLDKGADIN 29
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 117-209 5.23e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 37.96  E-value: 5.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060597009 117 LIAYGSNIDHKISHLGTPLYLACENQQRACVKKLLESGADVN-QGKGQDSPLHAVARTASEELACLLM-------DFGAD 188
Cdd:PTZ00322  101 LLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTlLDKDGKTPLELAEENGFREVVQLLSrhsqchfELGAN 180

                          90       100
                  ....*....|....*....|.
gi 1060597009 189 TQAKNAEGKRPVELvppDSPL 209
Cdd:PTZ00322  181 AKPDSFTGKPPSLE---DSPI 198
PHA03095 PHA03095
ankyrin-like protein; Provisional
 135-202 5.76e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 37.70  E-value: 5.76e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1060597009 135 LYLACENQQRAC---VKKLLESGADVNQGKGQDS-PLHAVARTASEELA---CLLMDFGADTQAKNAEGKRPVEL 202
Cdd:PHA03095   15 LYDYLLNASNVTveeVRRLLAAGADVNFRGEYGKtPLHLYLHYSSEKVKdivRLLLEAGADVNAPERCGFTPLHL 89
Ank_4 pfam13637
Ankyrin repeats (many copies);
133-182 7.06e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 34.17  E-value: 7.06e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1060597009 133 TPLYLACENQQRACVKKLLESGADVN-QGKGQDSPLHAVARTASEELACLL 182
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINaVDGNGETALHFAASNGNVEVLKLL 53
Ank_4 pfam13637
Ankyrin repeats (many copies);
37-86 7.64e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 33.79  E-value: 7.64e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1060597009  37 WSPMHEAAIYGHQLSLRNLIS---QVNGVTTDWHTPLFNACVSGSRDCVNLLL 86
Cdd:pfam13637   2 LTALHAAAASGHLELLRLLLEkgaDINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 133-158 8.11e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 33.38  E-value: 8.11e-03
                          10        20
                  ....*....|....*....|....*.
gi 1060597009 133 TPLYLACENQQRACVKKLLESGADVN 158
Cdd:pfam13606   4 TPLHLAARNGRLEIVKLLLENGADIN 29
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
83-199 8.34e-03

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 36.86  E-value: 8.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060597009  83 NLLLQHGASVQPESDLASPIHEAARRGHVECVDSLIAYGSNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQ-GK 161
Cdd:COG0666     6 LLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAkDD 85

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1060597009 162 GQDSPLHAVARTASEELACLLMDFGADTQAKNAEGKRP 199
Cdd:COG0666    86 GGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETP 123
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
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