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Conserved domains on  [gi|1084315495|ref|XP_018644586|]
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hypothetical protein Smp_190110, partial [Schistosoma mansoni]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
NADB_Rossmann super family cl21454
Rossmann-fold NAD(P)(+)-binding proteins; A large family of proteins that share a ...
5-58 3.06e-03

Rossmann-fold NAD(P)(+)-binding proteins; A large family of proteins that share a Rossmann-fold NAD(P)H/NAD(P)(+) binding (NADB) domain. The NADB domain is found in numerous dehydrogenases of metabolic pathways such as glycolysis, and many other redox enzymes. NAD binding involves numerous hydrogen-bonds and van der Waals contacts, in particular H-bonding of residues in a turn between the first strand and the subsequent helix of the Rossmann-fold topology. Characteristically, this turn exhibits a consensus binding pattern similar to GXGXXG, in which the first 2 glycines participate in NAD(P)-binding, and the third facilitates close packing of the helix to the beta-strand. Typically, proteins in this family contain a second domain in addition to the NADB domain, which is responsible for specifically binding a substrate and catalyzing a particular enzymatic reaction.


The actual alignment was detected with superfamily member COG5044:

Pssm-ID: 473865  Cd Length: 434  Bit Score: 33.22  E-value: 3.06e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1084315495   5 ILFPNISITPSLSQS----FLQL-SIPKLYHLTDSITQQLT---IEIFNNQLLPIMEVNRFM 58
Cdd:COG5044    81 FLFANSELLKILIETgvteYLEFkQISGSFLYRPGKIYKVPyneAEIFTSPLLSLFEKRRVM 142
 
Name Accession Description Interval E-value
MRS6 COG5044
RAB proteins geranylgeranyltransferase component A (RAB escort protein) [Posttranslational ...
5-58 3.06e-03

RAB proteins geranylgeranyltransferase component A (RAB escort protein) [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227377  Cd Length: 434  Bit Score: 33.22  E-value: 3.06e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1084315495   5 ILFPNISITPSLSQS----FLQL-SIPKLYHLTDSITQQLT---IEIFNNQLLPIMEVNRFM 58
Cdd:COG5044    81 FLFANSELLKILIETgvteYLEFkQISGSFLYRPGKIYKVPyneAEIFTSPLLSLFEKRRVM 142
 
Name Accession Description Interval E-value
MRS6 COG5044
RAB proteins geranylgeranyltransferase component A (RAB escort protein) [Posttranslational ...
5-58 3.06e-03

RAB proteins geranylgeranyltransferase component A (RAB escort protein) [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227377  Cd Length: 434  Bit Score: 33.22  E-value: 3.06e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1084315495   5 ILFPNISITPSLSQS----FLQL-SIPKLYHLTDSITQQLT---IEIFNNQLLPIMEVNRFM 58
Cdd:COG5044    81 FLFANSELLKILIETgvteYLEFkQISGSFLYRPGKIYKVPyneAEIFTSPLLSLFEKRRVM 142
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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