NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|10946916|ref|NP_067478|]
View 

myozenin-2 isoform 1 [Mus musculus]

Protein Classification

Calsarcin domain-containing protein( domain architecture ID 10527746)

Calsarcin domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
Calsarcin pfam05556
Calcineurin-binding protein (Calsarcin); This family consists of several mammalian ...
1-264 2.36e-111

Calcineurin-binding protein (Calsarcin); This family consists of several mammalian calcineurin-binding proteins. The calcium- and calmodulin-dependent protein phosphatase calcineurin has been implicated in the transduction of signals that control the hypertrophy of cardiac muscle and slow fibre gene expression in skeletal muscle. Calsarcin-1 and calsarcin-2 are expressed in developing cardiac and skeletal muscle during embryogenesis, but calsarcin-1 is expressed specifically in adult cardiac and slow-twitch skeletal muscle, whereas calsarcin-2 is restricted to fast skeletal muscle. Calsarcins represent a novel family of sarcomeric proteins that link calcineurin with the contractile apparatus, thereby potentially coupling muscle activity to calcineurin activation. Calsarcin-3, is expressed specifically in skeletal muscle and is enriched in fast-twitch muscle fibres. Like calsarcin-1 and calsarcin-2, calsarcin-3 interacts with calcineurin, and the Z-disc proteins alpha-actinin, gamma-filamin, and telethonin.


:

Pssm-ID: 461676  Cd Length: 255  Bit Score: 321.23  E-value: 2.36e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946916     1 MLSHSAMV-KQRKQQASAITKEIHG--HDVDGMDLGKKVSIPRDIMIEELSHFSNRGARLFKMRQRRSDKYTFENfqyes 77
Cdd:pfam05556   1 MPLSGTPApKEKKKKASKIIRELHGsePEASEMDLGKKISVPKDIMLEELSLLSNRGSKMFKMRQRRVEKFIYEN----- 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946916    78 raqinhniamqngrvdgsnleggsqqgpstPPNTPDPRSPPNPENIAPGYSGPLK-EIPPERFN---------------- 140
Cdd:pfam05556  76 ------------------------------NPDTFDSRSMDNPQKFAPSYGGQLKaPVPPPKPGskgagggggsgggggd 125
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946916   141 ------TTAVPKYYRSPWEQAIGSDPELLEALYPKLFKPEGKAELRDYRSFNRVATPFGGFEKASKMVKFKVPDFELLLL 214
Cdd:pfam05556 126 gadggkTTAVPKTYISPWEQAMGGDPELLETLKPKMPGPEPKPDLPKYKSFNRVAMPFGGFEKASKLMTFKLPEFDPLPE 205
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 10946916   215 tDPRFLAF-ANPLSGRRCFNRAPKGWVSENIPVVITTEPTEDATVPESDDL 264
Cdd:pfam05556 206 -EPEPAVLyQQDISKRPSFNRTPIGWVSSGEPSSIPLEVNAVPFDGETDDL 255
 
Name Accession Description Interval E-value
Calsarcin pfam05556
Calcineurin-binding protein (Calsarcin); This family consists of several mammalian ...
1-264 2.36e-111

Calcineurin-binding protein (Calsarcin); This family consists of several mammalian calcineurin-binding proteins. The calcium- and calmodulin-dependent protein phosphatase calcineurin has been implicated in the transduction of signals that control the hypertrophy of cardiac muscle and slow fibre gene expression in skeletal muscle. Calsarcin-1 and calsarcin-2 are expressed in developing cardiac and skeletal muscle during embryogenesis, but calsarcin-1 is expressed specifically in adult cardiac and slow-twitch skeletal muscle, whereas calsarcin-2 is restricted to fast skeletal muscle. Calsarcins represent a novel family of sarcomeric proteins that link calcineurin with the contractile apparatus, thereby potentially coupling muscle activity to calcineurin activation. Calsarcin-3, is expressed specifically in skeletal muscle and is enriched in fast-twitch muscle fibres. Like calsarcin-1 and calsarcin-2, calsarcin-3 interacts with calcineurin, and the Z-disc proteins alpha-actinin, gamma-filamin, and telethonin.


Pssm-ID: 461676  Cd Length: 255  Bit Score: 321.23  E-value: 2.36e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946916     1 MLSHSAMV-KQRKQQASAITKEIHG--HDVDGMDLGKKVSIPRDIMIEELSHFSNRGARLFKMRQRRSDKYTFENfqyes 77
Cdd:pfam05556   1 MPLSGTPApKEKKKKASKIIRELHGsePEASEMDLGKKISVPKDIMLEELSLLSNRGSKMFKMRQRRVEKFIYEN----- 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946916    78 raqinhniamqngrvdgsnleggsqqgpstPPNTPDPRSPPNPENIAPGYSGPLK-EIPPERFN---------------- 140
Cdd:pfam05556  76 ------------------------------NPDTFDSRSMDNPQKFAPSYGGQLKaPVPPPKPGskgagggggsgggggd 125
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946916   141 ------TTAVPKYYRSPWEQAIGSDPELLEALYPKLFKPEGKAELRDYRSFNRVATPFGGFEKASKMVKFKVPDFELLLL 214
Cdd:pfam05556 126 gadggkTTAVPKTYISPWEQAMGGDPELLETLKPKMPGPEPKPDLPKYKSFNRVAMPFGGFEKASKLMTFKLPEFDPLPE 205
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 10946916   215 tDPRFLAF-ANPLSGRRCFNRAPKGWVSENIPVVITTEPTEDATVPESDDL 264
Cdd:pfam05556 206 -EPEPAVLyQQDISKRPSFNRTPIGWVSSGEPSSIPLEVNAVPFDGETDDL 255
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
103-262 8.89e-04

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 40.44  E-value: 8.89e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946916  103 QGPSTPPNTPDPRSPPNPEniapgysgplKEIPPERFNTTAVPKYYRSPWEQAIGSDPELLEALYPKLFKPEGKAElrdy 182
Cdd:PTZ00449 622 KSPKRPESPKSPKRPPPPQ----------RPSSPERPEGPKIIKSPKPPKSPKPPFDPKFKEKFYDDYLDAAAKSK---- 687
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946916  183 rsfnRVATPFGGFEKASKMVKFKVPDFELLLLTDPRFLAFANPLSGRrcFNRAPKGwvsenIPVVITTEPTEDATVPESD 262
Cdd:PTZ00449 688 ----ETKTTVVLDESFESILKETLPETPGTPFTTPRPLPPKLPRDEE--FPFEPIG-----DPDAEQPDDIEFFTPPEEE 756
 
Name Accession Description Interval E-value
Calsarcin pfam05556
Calcineurin-binding protein (Calsarcin); This family consists of several mammalian ...
1-264 2.36e-111

Calcineurin-binding protein (Calsarcin); This family consists of several mammalian calcineurin-binding proteins. The calcium- and calmodulin-dependent protein phosphatase calcineurin has been implicated in the transduction of signals that control the hypertrophy of cardiac muscle and slow fibre gene expression in skeletal muscle. Calsarcin-1 and calsarcin-2 are expressed in developing cardiac and skeletal muscle during embryogenesis, but calsarcin-1 is expressed specifically in adult cardiac and slow-twitch skeletal muscle, whereas calsarcin-2 is restricted to fast skeletal muscle. Calsarcins represent a novel family of sarcomeric proteins that link calcineurin with the contractile apparatus, thereby potentially coupling muscle activity to calcineurin activation. Calsarcin-3, is expressed specifically in skeletal muscle and is enriched in fast-twitch muscle fibres. Like calsarcin-1 and calsarcin-2, calsarcin-3 interacts with calcineurin, and the Z-disc proteins alpha-actinin, gamma-filamin, and telethonin.


Pssm-ID: 461676  Cd Length: 255  Bit Score: 321.23  E-value: 2.36e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946916     1 MLSHSAMV-KQRKQQASAITKEIHG--HDVDGMDLGKKVSIPRDIMIEELSHFSNRGARLFKMRQRRSDKYTFENfqyes 77
Cdd:pfam05556   1 MPLSGTPApKEKKKKASKIIRELHGsePEASEMDLGKKISVPKDIMLEELSLLSNRGSKMFKMRQRRVEKFIYEN----- 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946916    78 raqinhniamqngrvdgsnleggsqqgpstPPNTPDPRSPPNPENIAPGYSGPLK-EIPPERFN---------------- 140
Cdd:pfam05556  76 ------------------------------NPDTFDSRSMDNPQKFAPSYGGQLKaPVPPPKPGskgagggggsgggggd 125
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946916   141 ------TTAVPKYYRSPWEQAIGSDPELLEALYPKLFKPEGKAELRDYRSFNRVATPFGGFEKASKMVKFKVPDFELLLL 214
Cdd:pfam05556 126 gadggkTTAVPKTYISPWEQAMGGDPELLETLKPKMPGPEPKPDLPKYKSFNRVAMPFGGFEKASKLMTFKLPEFDPLPE 205
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 10946916   215 tDPRFLAF-ANPLSGRRCFNRAPKGWVSENIPVVITTEPTEDATVPESDDL 264
Cdd:pfam05556 206 -EPEPAVLyQQDISKRPSFNRTPIGWVSSGEPSSIPLEVNAVPFDGETDDL 255
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
103-262 8.89e-04

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 40.44  E-value: 8.89e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946916  103 QGPSTPPNTPDPRSPPNPEniapgysgplKEIPPERFNTTAVPKYYRSPWEQAIGSDPELLEALYPKLFKPEGKAElrdy 182
Cdd:PTZ00449 622 KSPKRPESPKSPKRPPPPQ----------RPSSPERPEGPKIIKSPKPPKSPKPPFDPKFKEKFYDDYLDAAAKSK---- 687
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946916  183 rsfnRVATPFGGFEKASKMVKFKVPDFELLLLTDPRFLAFANPLSGRrcFNRAPKGwvsenIPVVITTEPTEDATVPESD 262
Cdd:PTZ00449 688 ----ETKTTVVLDESFESILKETLPETPGTPFTTPRPLPPKLPRDEE--FPFEPIG-----DPDAEQPDDIEFFTPPEEE 756
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH