|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
22-397 |
2.10e-138 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 400.46 E-value: 2.10e-138
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 22 ATISQTFATFVTYGIGPLASLWQQVHHLSQFQTGLLVSAVNIGPIFSMLPFGNLMDRYGERWIVGVGSVFLGASMLLAYP 101
Cdd:cd17475 1 ATLAQAAASLVAQGIPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 102 VTNYTYLVVILLFVGIWYGTAQPGGSKAIVKWFPPQRRGLAMGIRQTGIPIGGALASSTLPFFFYKYGLPSVILVQAIVT 181
Cdd:cd17475 81 VGSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 182 ISGGLLFILFYREERSTIQKIETAS-FLTKLKQIRRNDSLYPIFLIGITMMSLQMVLVSHLMSYLTNEVHTNLHHAGTLL 260
Cdd:cd17475 161 ILAAVLFWLFYREPPAASAATESAStLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 261 SVVLLGGMIGRILLAWTSDNIFKGNRVIPLQITIGITILLLLCMSFVMPYITFWLLVILCFFLGFFAIGWFSLFIVLVSE 340
Cdd:cd17475 241 AVAQLGGALGRIGLGRVSDRVFGGRRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFAIGWNGLYLTLVAE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1098108237 341 RSDPQFIGLTVSFALTLNQFAIVLAPALFGILVDYLHSYAAPFSILALLIALSGIWL 397
Cdd:cd17475 321 SAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLAALLL 377
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
13-406 |
2.66e-49 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 171.60 E-value: 2.66e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 13 SYRWVILLIATISQTFATFVTYGIGPLASLWQQVHHLSQFQTGLLVSAVNIGPIFSMLPFGNLMDRYGERWIVGVGSVFL 92
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 93 GASMLLAYPVTNYTYLVVILLFVGIWYGTAQPGGSKAIVKWFPPQRRGLAMGIRQTGIPIGGALASSTLPFFFYKYGLPS 172
Cdd:COG2223 81 GIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 173 VILVQAIVTISGGLLFILFYREERSTIQKIETASFLTkLKQIRRNDSLYPIFLIGITMMSLQMVLVSHLMSYLTNEVHTN 252
Cdd:COG2223 161 AFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRD-QLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLS 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 253 LHHAGTLLSVVLLGGMIGRILLAWTSDNIfkgNRVIPLQITIGITILLLLCMSFVMPyiTFWLLVILCFFLGFFAIGWFS 332
Cdd:COG2223 240 AATAGLLAALFALLGALGRPLGGWLSDRI---GGRRVLLIVFALMALGLLLLALALG--SLWLFLVLFLLLGLALGGGNG 314
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1098108237 333 LFIVLVSERSDPQFIGLTVSFALTLNQFAIVLAPALFGILVDYLHSYAAPFSILALLIALSGIWLTITEYRNKQ 406
Cdd:COG2223 315 AVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTLLLYRRPRR 388
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
8-399 |
2.82e-46 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 162.73 E-value: 2.82e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 8 NDSTSSYRWVILLIATISQTFATFVTYGIGPLASLWQQVHHLSQFQTGLLVSAVNIGPIFSMLPFGNLMDRYGERWIVGV 87
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 88 GSVFLGASMLLAYPVTNYTYLVVILLFVGIWYGTAQPGGSKAIVKWFPPQRRGLAMGIRQTGIPIGGALASSTLPFFFYK 167
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 168 YGLPSVILVQAIVTISGGLLFILFyreerstiqkietasfltklkqirrndslypIFLIGITMMSLQMVLVSHLMSYLTN 247
Cdd:COG2271 161 FGWRAAFLILGLPGLLLALLRFWL-------------------------------LALAYFLVYFALYGFLTWLPTYLVE 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 248 EVHTNLHHAGTLLSVVLLGGMIGRILLAWTSDNIFKGNRVIplqiTIGITILLLLCMSFVMPYITFWLLVILCFFLGFFA 327
Cdd:COG2271 210 VRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLV----LAIGLLLAALALLLLALLPSPALAIALLFLAGFGL 285
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1098108237 328 IGWFSLFIVLVSERSDPQFIGLTVSFALTLNQFAIVLAPALFGILVDYLHsYAAPFSILALLIALSGIWLTI 399
Cdd:COG2271 286 GGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG-YQAAFLLLAALALLAALLALL 356
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
10-365 |
5.96e-32 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 123.93 E-value: 5.96e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 10 STSSYRWVILLIATISQTFATFVTYGIGPLASLWQQVHHLSQFQTGLLVSAVNIGPIFSMLPFGNLMDRYGERWIVGVGS 89
Cdd:COG2814 3 ATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 90 VFLGASMLLAYPVTNYTYLVVILLFVGIWYGTAQPGGSKAIVKWFPPQRRGLAMGIRQTGIPIGGALASSTLPFFFYKYG 169
Cdd:COG2814 83 LLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 170 LPSVILVQAIVTISGGLLFILFYREERstiqKIETASFLTKLKQIRRNDSLYPIFLIGITMMSLQMVLVSHLMSYLTNEV 249
Cdd:COG2814 163 WRWVFLVNAVLALLALLLLLRLLPESR----PAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 250 HTNLHHAGTLLSVVLLGGMIGRILLAWTSDnifkgnRVIPLQITIGITILLLLCMSFVMPYITFWLLVILCFFLGFFAIG 329
Cdd:COG2814 239 GLSASAAGLLLALFGLGGVLGALLAGRLAD------RFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGL 312
|
330 340 350
....*....|....*....|....*....|....*.
gi 1098108237 330 WFSLFIVLVSERSDPQFIGLTVSFALTLNQFAIVLA 365
Cdd:COG2814 313 LFPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
27-399 |
2.83e-30 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 119.99 E-value: 2.83e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 27 TFATFVTYGI-GPLASLWQQVHHLSQFQTGLLVSAVNIGPIFSMLPFGNLMDRYGERWIVGVGSVFLGASMLLAYPVTNY 105
Cdd:cd17325 5 LFLDMLGYGIiIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSY 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 106 TYLVVILLFVGIWYGTAQPGGSKAIVKWFPPQRRGLAMGIRQTGIPIGGALASSTLPFFFYKYGLPSVILVQAIVTISGG 185
Cdd:cd17325 85 WQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLAL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 186 LLFILFYREERSTI--QKIETASFLTKLKQIRRNDSLYPIFLIGITMMSLQMVLVSHLMSYLTNEVHTNLHHAGTLLSVV 263
Cdd:cd17325 165 VLALLLLPEPRPPPnkRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQ 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 264 LLGGMIGRILLAWTSDnifKGNRVIPLQITIGITILLLLCMSFVmpyITFWLLVILCFFLGFFAIGWFSLFIVLVSERSD 343
Cdd:cd17325 245 GLASALSQPPAGKLSD---RIGRKPLILIGLLLSAVALLLLPLA---TSFWLLLLLLALLGLGLGLVFPATLALLADIVP 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1098108237 344 PQFIGLTVSFALTLNQFAIVLAPALFGILVDYLhSYAAPFSILALLIALSGIWLTI 399
Cdd:cd17325 319 PEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAF-GFATPFLAAAALLLLAAVLFLL 373
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
1-395 |
7.43e-30 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 119.21 E-value: 7.43e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 1 MQKQKTRNDSTSSYR--WVILLIATISQTFATFVTyGIGPLASLWQQVHHLSQFQTGLLVSAVNIGPIFSMLPFGNLMDR 78
Cdd:COG2807 1 MSTTSSSARRSRRAGrwLLLLAIVLVALNLRPAIT-SVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 79 YGERWIVGVGSVFLGASMLLAYPVTNYTYLVVILLFVGIWYGTAQPGGSKAIVKWFpPQRRGLAMGIRQTGIPIGGALAS 158
Cdd:COG2807 80 FGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWF-PDRVGLMTGLYTAAMGLGAALAA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 159 STLPFFFYKYGLPSVILVQAIVTISGGLLFILFYREERSTIQkieTASFLTKLKQIRRNDSLYPIFLIGITMMSLQMVLV 238
Cdd:COG2807 159 GLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAAA---AAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVV 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 239 SHLMSYLTnEVHTNLHHAGTLLSVVLLGGMIGRILLAWTSDNIfkGNRVIPLQITIGITILLLLCMSFvMPYITFWLLVI 318
Cdd:COG2807 236 AWLPPILR-DAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRL--GDRRPLLLLLGLLGLAGLLGLLL-APGSLPWLWAV 311
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1098108237 319 LcffLGFFAIGWFSLFIVLVSERS-DPQFIGLTVSFALTLNQFAIVLAPALFGILVDYLHSYAAPFSILALLIALSGI 395
Cdd:COG2807 312 L---LGLGQGGLFPLALTLIGLRArTPAEAAALSGMAQSVGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLV 386
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
48-399 |
1.05e-28 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 115.36 E-value: 1.05e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 48 HLSQFQTGLLVSAVNIGPIFSMLPFGNLMDRYGERWIVGVGSVFLGASMLLAYPVTNYTYLVVILLFVGIWYGTAQPGGS 127
Cdd:cd17319 34 GLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFPGAI 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 128 KAIVKWFPPQRRGLAMGIRQTGIPIGGALASSTLPFFFYKYGLPSVILVQAIVTISGGLLFILFYReerstiqkietasf 207
Cdd:cd17319 114 KALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLR-------------- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 208 ltklkqirrndSLYPIFLIGITMMSLQMVLVSHLMSYLTNEVHTNLHHAGTLLSVVLLGGMIGRILLAWTSDNIFKGNRV 287
Cdd:cd17319 180 -----------QVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGARR 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 288 IPLqitIGITILLLLCMSFVMPYITFWLLVILCFFLGFFAIGWFSLFIVLVSERSDPQFIGLTVSFALTLNQFAIVLAPA 367
Cdd:cd17319 249 LVI---IIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPL 325
|
330 340 350
....*....|....*....|....*....|..
gi 1098108237 368 LFGILVDYLHSYAAPFSILALLIALSGIWLTI 399
Cdd:cd17319 326 LIGYLVDATGSYTAAFLFLAAVALLAALLVLL 357
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
24-366 |
2.33e-28 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 114.05 E-value: 2.33e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 24 ISQTFATFVTYGIGPLASLW-QQVHHLSQFQTGLLVSAVNIGPIFSMLPFGNLMDRYGERWIVGVGSVFLGASMLLAYPV 102
Cdd:pfam07690 3 LAAFLAALGRSLLGPALPLLlAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 103 TNYTYLVVILLFVGIWYGTAQPGGSKAIVKWFPPQRRGLAMGIRQTGIPIGGALASSTLPFFFYKYGLPSVILVQAIVTI 182
Cdd:pfam07690 83 SSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 183 SGGLLFILFYREERSTIQKIETASFLTKLKQIR--RNDSLYPIFLIGITMMSLQMVLVSHLMSYLTnEVHTNLHHAGTLL 260
Cdd:pfam07690 163 LAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKalLRDPVLWLLLALLLFGFAFFGLLTYLPLYQE-VLGLSALLAGLLL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 261 SVVLLGGMIGRILLAWTSDNIFKGNRVIplqITIGITILLLLCMSFVMPYITFWLLVILCFFLGFFAIGWFSLFIVLVSE 340
Cdd:pfam07690 242 GLGGLLGAIGRLLLGRLSDRLGRRRRLL---LALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSD 318
|
330 340
....*....|....*....|....*.
gi 1098108237 341 RSDPQFIGLTVSFALTLNQFAIVLAP 366
Cdd:pfam07690 319 LAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
31-395 |
9.63e-24 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 101.73 E-value: 9.63e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 31 FVTYGIGPLASLWQQVHHLSQFQTGLLVSAVNIGPIFSMLPFGNLMDRYGERWIVGVGSVFLGASMLLAYPVTNYTYLVV 110
Cdd:cd06174 10 LARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 111 ILLFVGIWYGTAQPGGSKAIVKWFPPQRRGLAMGIRQTGIPIGGALASSTLPFFFY--KYGLPSVILVQAIVTISGGLLF 188
Cdd:cd06174 90 GRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASslGFGWRAVFLIAAALALLAAILL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 189 ILFYREERSTIQK----IETASFLTKLKQIRRNDSLYPIFLIGITMMSLQMVLVSHLMSYLTNEVHTNLHHAGTLLSVVL 264
Cdd:cd06174 170 LLVVPDPPESARAkneeASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFG 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 265 LGGMIGRILLAWTSDNIFKGNRVIPLQITIGITILLLLCMSFvmpyiTFWLLVILCFFLGFFAIGWFSLFIVLVSERSDP 344
Cdd:cd06174 250 LAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAP-----SLLLLLLLLLLLGFGLGGLLPLSFALIAELFPP 324
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1098108237 345 QFIGLTVSFALTLNQFAIVLAPALFGILVDYLHSYAAPFSILALLIALSGI 395
Cdd:cd06174 325 EIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAI 375
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
16-395 |
1.06e-21 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 95.80 E-value: 1.06e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 16 WVILLIATISQTFATFVTYGIGPLASLWQQVHHLSQFQTGLLVSAVNIGPIFSMLPFGNLMDRYGERWIVGVGSVFLGAS 95
Cdd:cd17355 2 WVVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 96 MLLAYPVTNYTYLVV-ILLFVGIWYGTAQPGGSKAIVKWFPPQRRGLAMGIRQTGIPIGGALASSTLPFFFYKYGLPSVI 174
Cdd:cd17355 82 LVLLALATSLWQLYLlWGLLGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 175 LVQAIVTISGGLLFILFYREERSTIQK-----IETASFLTKLKQIRRNdSLYPIFLIGITMMSLQMV-LVSHLMSYLTnE 248
Cdd:cd17355 162 LVLALLALLVLVPVLLLLRRRPADLALrayddASPASPGSTLKEALRS-ASFWLLALAFFLCGFAVVgLIVHLVPYLA-D 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 249 VHTNLHHAGTLLSVVLLGGMIGRILLAWTSDNIFKGNRVIPLQITIGITILLLLcmSFVMPYITFWLLVIlcfFLGFFAI 328
Cdd:cd17355 240 RGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLL--LLPFPPLALLLFAA---LFGLGWG 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1098108237 329 GWFSLFIVLVSERSDPQFIGLTVSFALTLNQFAIVLAPALFGILVDYLHSYAAPFSILALLIALSGI 395
Cdd:cd17355 315 ATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAAL 381
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
16-399 |
1.15e-21 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 95.31 E-value: 1.15e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 16 WVILLIATISQTFATFVTYGIGPLASLWQQVHHLSQFQTGLlVSAVNIGPIFSMLPF-GNLMDRYGERWIVGVGSVFLGA 94
Cdd:cd17352 2 WVVVFASFLVNFFTDGILNSFGVLFVELLEEFGESTSDIAW-IGSLLLGVSLFSGPLsSALVNRFGCRPVAIAGGLLAAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 95 SMLLAYPVTNYTYLVVIL-LFVGIWYGTAQPGGSKAIVKWFPpQRRGLAMGIRQTGIPIGGALASSTLPFFFYKYGLPSV 173
Cdd:cd17352 81 GLLLSSFATSLWQLYLTYgVLGGLGLGLIYSPAIVIVGQYFE-KKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 174 ILVQAIVTISGgLLFILFYREERSTIQKIETASFLtklkqirrndslypIFLIGITMMSlqMVLVSHLMSYLTNEvhtnl 253
Cdd:cd17352 160 LLILGGLCLNL-CVCGLLLRLLKDPTFVLLALGVS--------------FAMLGFFVPF--VYLPSYAKSLGIDE----- 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 254 HHAGTLLSVVLLGGMIGRILLAWTSD--NIFKGNRVIplqITIGITILLLLCMSFvmpYITFWLLVILCFFLGFFAIGWF 331
Cdd:cd17352 218 SDAAFLLSIIGISDIVGRILLGLLADkpRIGRLYLYI---FTLLILGLSLLAFPL---ATTYVGLIVFSVLFGFCSGSYS 291
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1098108237 332 SLFIVLVSERSDPQFIGLTVSFALTLNQFAIVLAPALFGILVDYLHSYAAPFSILALLIALSGIWLTI 399
Cdd:cd17352 292 SLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAFYFCGACLLLSGVLLFL 359
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
49-377 |
2.05e-21 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 95.14 E-value: 2.05e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 49 LSQFQTGLLVSAVNIGPIFSMLPFGNLMDRYGERWIVGVGSVFLGASMLLAYPVTNYTYLVVILLFVGIWYGTAQPGGSK 128
Cdd:TIGR00881 27 LSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQGMGWPPCGR 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 129 AIVKWFPPQRRGLAMGIRQTGIPIGGALASSTLPFFF-YKYGLPSVILVQAIVTISGGLLFILFYREERSTI-------- 199
Cdd:TIGR00881 107 TVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIaELYSWHWVFIVPGIIAIIVSLICFLLLRDSPQSCglppaeem 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 200 --------QKIETASFLTK---LKQIRRNDSLYPIFLIGITMMSLQMVLVSHLMSYLTNEVHTNLHHAGTLLSVVLLGGM 268
Cdd:TIGR00881 187 pneepdgdAEKKEEELTKKqifLQYVLLNKVLWYISLGYVFVYVVRTGILDWSPLYLTQEKGFSKEKASWAFTLYELGGL 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 269 IGRILLAWTSDNIFKGNR-VIPLQITIGITILLLLcmSFVMPYITFWLLVILCFFLGFFAIGWFSLFIVLVSERSDPQFI 347
Cdd:TIGR00881 267 VGTLLAGWLSDKLFNGRRgPLAVFFMALIIVSLLV--YWLNPAANPLMDLICLFALGFLVYGPQMLIGVIASELAPKKAA 344
|
330 340 350
....*....|....*....|....*....|
gi 1098108237 348 GLTVSFALTLNQFAIVLAPALFGILVDYLH 377
Cdd:TIGR00881 345 GTAAGFVGFFAYLGGILAGLPLGYLADGFG 374
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
27-396 |
4.03e-21 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 93.81 E-value: 4.03e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 27 TFATFVTYGIgPLASLWQQVHHL--SQFQTGLLVSAVNIGPIFSMLPFGNLMDRYGERWIVGVGSVFLGASMLLAYPVTN 104
Cdd:cd17489 5 NFFFFLSFYL-LLPVLPLYAHDLggSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 105 YTYLVVILLFVGIWYGTAQPGGSKAIVKWFPPQRRGLAMGIRQTGIPIGGALASSTLPFFFYKYGLPSVILVqAIVTISG 184
Cdd:cd17489 84 VALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIV-AAVLALL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 185 GLLFILFYREErsTIQKIETASFLTKLKQIRRNDSLYPIFLIGITMMSLQMVLVSHLMSYLtneVHTNLHHAGTLLSVVL 264
Cdd:cd17489 163 ALLLVFLVKDP--PPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYA---AERGISNAGLFFTVYA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 265 LGGMIGRILLAWTSDnifKGNRVIPLQITIGITILLLLCMSFVmpyITFWLLVILCFFLGFFAIGWFSLFIVLVSERSDP 344
Cdd:cd17489 238 IALLLSRPFSGKLSD---RKGPKTVIIPGLLLLALGLLLLSFA---GSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPP 311
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 1098108237 345 QFIGLTVSFALTLNQFAIVLAPALFGILVDYLhSYAAPFSILALLIALSGIW 396
Cdd:cd17489 312 HRRGAANGTFFIFFDLGIGLGGLLLGLVAELF-GYRAMFLLAAVVVLLALVL 362
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
10-392 |
9.68e-21 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 92.99 E-value: 9.68e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 10 STSSYRWVILLIATISQTFAtFVTYGIGPLASLWQQVHHLSQFQTGLLVSAVNIGPIFSMLPFGNLMDRYGERWIVGVGS 89
Cdd:COG0738 2 SKKNYRRALIAIYLLFFLWG-FATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 90 VFLGASMLLAYPVTNYTYLVVILLFVGIWYGTAQPGGSkAIVKWFPPQRRGLAMGIRQTGIPIGGALASSTLPFFFYKYG 169
Cdd:COG0738 81 LLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAAN-PYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 170 LPSVILVQAIVTISGGLLFILFYREE--RSTIQKIETASFLTKLKQIRRNDSLYPIFLIGITMMSLQMVLVSHLMSYLTN 247
Cdd:COG0738 160 SLSWHLPYLILAVLLLLLALLFLRSKlpEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKD 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 248 EVHTNLHHAGTLLSVVLLGGMIGRILLAWTSDNIfkgNRVIPLQITIGITILLLLCMSFVMpyiTFWLLVILCFFLGFFA 327
Cdd:COG0738 240 VLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRF---GPVRLLRLSALLAAVGLLLALLAP---GPWLALIGLALVGLGL 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1098108237 328 IGWFSLFIVLVSERSdPQFIGLTVSFALTLNQFAIVLAPALFGILVDYLHSYAAPFSILALLIAL 392
Cdd:COG0738 314 SLMFPTIFSLALDGL-GKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLI 377
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
15-395 |
2.15e-19 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 89.21 E-value: 2.15e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 15 RWVILLIATISQTFATFVTYGIGPLASLWQQVHHLSQFQTGLLVSAVNIGPIFSMLPFGNLMDRYGERWIVGVGSVFLGA 94
Cdd:cd17353 1 RRWLVLLGAVLMHLILGYQYAWSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 95 SMLLAYPVTNYTYLVVIL-LFVGIWYGTAQPGGSKAIVKWFpPQRRGLAMGIRQTGIPIGGALASSTLPFFFYKYGLPSV 173
Cdd:cd17353 81 GFILSAFAISLPLLFLGYgVLGGIGAGIGYITPVSTAVKWF-PDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTT 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 174 ILVQAIvtISGGLLFIL--FYREERSTIQKIETASFLTKLKQIRRNDSL---------YPIFLIGITMMSLQMVLVSHLM 242
Cdd:cd17353 160 FLILGI--IFLIIIVIGafLIRDPPKGWVPPGVDPLANNAENSPRDYTPremlrtptfWLLWLMFFLNATAGLMLIGQAK 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 243 SYLTNEVHTNLHHAGTLLSVVLLGGMIGRILLAWTSDNIFKGNrviplqiTIGITILLLLCMSFVMPYI--TFWLLVILC 320
Cdd:cd17353 238 PIGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKN-------TLSIAFLIQGVAMFLLPFIgsVAVLFVLGV 310
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1098108237 321 FFLGFFAIGWFSLFIVLVSERSDPQFIGLTVSFALTLNQFAIVLAPALFGiLVDYLHSYAAPFSILALLIALSGI 395
Cdd:cd17353 311 ALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAA-YVLYTGGYNAAFIIAAALSLVALA 384
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
38-395 |
3.24e-19 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 88.38 E-value: 3.24e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 38 PLASLWQQVHHLSQFQTGLLVSAVNIGPIFSMLPFGNLMDRYGERWIVGVGSVFLGASMLLAYPVTNYTYLVVILLFVGI 117
Cdd:cd17478 17 ALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGI 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 118 WYGTAQPGGSkAIVKWFPPQRRGLAMGIRQTGIPIGGALASSTLPFFFYKYGLPSVILVQAIVTISGGLLFILFYReERS 197
Cdd:cd17478 97 GSAAFHPEGA-RLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRP-LKK 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 198 TIQKIETASFLTKLKQIRRNDSLYPIFLIGITMMSLQMVLVSHLMSYLTNEVHTNLhHAGTLLSVVLLGGMIGRILLAWT 277
Cdd:cd17478 175 PEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLV-FAGLLLSLFLFAGAIGTLIGGPL 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 278 SDNIfkGNRVIPLQITIGITILLLLcmsfvMPYITFWLLVILCFFLGFFAIGWFSLFIVLVSErSDPQFIGLTVSFALTL 357
Cdd:cd17478 254 SDRF--GRRRVIIASLLLAAPFLLL-----FLLTPGIWSYILLVLAGFLLFASFPVTVVLAQE-LLPGNVGLASGLMMGL 325
|
330 340 350
....*....|....*....|....*....|....*...
gi 1098108237 358 NQFAIVLAPALFGILVDYlHSYAAPFSILALLIALSGI 395
Cdd:cd17478 326 SFGLGGIGAPVLGALADA-FGLESVLLILALLPLLGAL 362
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
27-397 |
1.37e-17 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 83.75 E-value: 1.37e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 27 TFATFVT-YGIGPLASLWQQVHHLSQFQTGLLVSAVNIGPIFSMLPFGNLMDRYGERWIVGVGSVFLGASMLLAYPVTNY 105
Cdd:cd17324 8 AFAIGTTeYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSF 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 106 TYLVVILLFVGIWYGTAQPGGSKAIVKWFPPQRRGLAMGIRQTGIPIGGALASSTLPFFFYKYGLPSVILVQAIVTISGG 185
Cdd:cd17324 88 ALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAA 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 186 LLFILFYREERStiQKIETASFLTKLKQIRRNDSLYPIFLIGITMMSLQMVLVSHLMSYLTNEVHTNLHHAGTLLSVVLL 265
Cdd:cd17324 168 LLLWRLLPSLPP--KKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGV 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 266 GGMIGRILLAWTSDNIFKGNrviplqITIGITILLLLCMSFVMPYITFWLLVILCFFLGFFAIGWFSLFIVLVSERSdPQ 345
Cdd:cd17324 246 AGVVGSPLAGRLADRGGRRA------LLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLA-PE 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 1098108237 346 FIGLTVSFALTLNQFAIVLAPALFGILVDYLHSYAAPFSILALLIALSGIWL 397
Cdd:cd17324 319 ARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
15-352 |
1.85e-17 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 83.09 E-value: 1.85e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 15 RWVILLIATISQTFATFVTYGIGPLASLWQQVHHLSQFQTGLLVSAVNIGPIFSMLPFGNLMDRYGERWIVGVGSVFLGA 94
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 95 SMLLAYPVTNYTYLVVILLFVGIWYGTAQPGGSKAIVKWFPPQRRGLAMGIRQTGIPIGGALASSTLPFFFYKYGLPSVI 174
Cdd:cd17312 81 ANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 175 LVQAIVTISGGLLFILFYREERSTIQKIETASFLTKLkqirrndSLYPIFLIGITmmslqmvlvshlmsYLTNEVHTNLH 254
Cdd:cd17312 161 LVPGIVGLVVAIILFFFLRDSPPYVWVLSLAYAFVYI-------VRYACLDWGPL--------------YLYEVKGYSLI 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 255 HAGTLLSVVLLGGMIGRILLAWTSDNIFKGNRVIPLQITIGITILLLLCMSFVMPYitfWLLVILCFFL-GFFAIGWFSL 333
Cdd:cd17312 220 DAGWFSSLYEVGGIAGTILAGLLSDKLFGGRRAPIAVIYMLLMTLSLALFWFFPHN---KLLSIVLLFLiGFFVGGPINL 296
|
330
....*....|....*....
gi 1098108237 334 FIVLVSERSDPQFIGLTVS 352
Cdd:cd17312 297 IGGAAAQDIGRKEAAGTAT 315
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
36-396 |
5.24e-16 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 78.75 E-value: 5.24e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 36 IGPLASLWQQVHHLSQFQTGLLVSAVNIGPIFSMLPFGNLMDRYGERWIVGVGSVFLGASMLLAYPVTNYTYLVVILLFV 115
Cdd:cd17477 15 LLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVM 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 116 GIWYGTAQPGGSKAIVKWFPPQRRGLAMGIRQTGIPIGGALASSTLPFFfykYGLPSVILVQAIVTISGGLLFILFYREE 195
Cdd:cd17477 95 GIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALV---GTAGALPFLIAAVLLLLALVPLLLTRRA 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 196 RSTIQKIETASFLTKLKQIRRndSLYPIFLIGITMMSLQMvlvshLMSYLTNEVHTNLHHAGTLLSVVLLGGMIGRILLA 275
Cdd:cd17477 172 APEIEEAESISLRRLLRIAPL--ALLGAFVAGFLEGAFYS-----LLPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLG 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 276 WTSDnifKGNRVIPLQITIGITILLLLCMSFVMPyiTFWLLVILCFFLGFFAIGWFSLFIVLVSERSDPQFIGLTVSFAL 355
Cdd:cd17477 245 WLAD---RFDRRRVLLGCALLGALAALLLPLVPG--LPLALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVAANAALL 319
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 1098108237 356 TLNQFAIVLAPALFGILVDYLHSYAAPFSILALLIALSGIW 396
Cdd:cd17477 320 LLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
49-395 |
1.48e-15 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 77.24 E-value: 1.48e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 49 LSQFQTGLLVSAVNIGPIFSMLPFGNLMDRYGERWIVGVGSVFLGASMLLAYPVTNYTYLVVILLFVGIWYGTAQPGGSK 128
Cdd:cd17365 31 LSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAMPNAIT 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 129 AIVKWFPPQRRGLAMGIRQTGIPIGGALASSTLPFFFYKYGLPSVILVQAIVTIsggLLFILFyreeRSTiqkietasfl 208
Cdd:cd17365 111 LVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPL---ILLPLL----RGT---------- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 209 tklkqirrndslypIFLIGITMMSLQMV-LVSHLMSYLTNEVHTNLHHAGTLLSVVLLGGMIGRILLAWTSDnifKGNRV 287
Cdd:cd17365 174 --------------LLLWVTFFMGLLLVyLLNSWLPKLMVEAGYSLSQALTITLLLNIGGVIGSLLLGWLAD---RFGPK 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 288 IPLQITIGITILLLLCMSFVMPyiTFWLLVILCFFLGFFAIGWFSLFIVLVSERSDPQFIGLTVSFALTLNQFAIVLAPA 367
Cdd:cd17365 237 RVLALFFALGAVSLALLGVSPA--SLVLLYVLVFLAGACVNGAQVGLYALAARFYPTEVRATGVGWALGVGRLGAILGPL 314
|
330 340
....*....|....*....|....*...
gi 1098108237 368 LFGILVDYLHSYAAPFSILALLIALSGI 395
Cdd:cd17365 315 LGGLLLAAGLGPESVFLALAIPAALGAL 342
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
19-192 |
2.24e-15 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 76.85 E-value: 2.24e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 19 LLIATISQTFATFVTYGIGPLASLW-QQVHHLSQFQTGLLVSAVNIGPIFSMLPFGNLMDRYGERWIVGVGSVFLGASML 97
Cdd:cd17325 201 LLALFLAIFVLAFAFGALEPFLPLYaAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALL 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 98 LAYPVTNYTYLVVILLFVGIWYGTAQPGGSKAIVKWFPPQRRGLAMGIRQTGIPIGGALASSTLPFFFYKYGLPSVILVQ 177
Cdd:cd17325 281 LLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAA 360
|
170
....*....|....*
gi 1098108237 178 AIVTISGGLLFILFY 192
Cdd:cd17325 361 AALLLLAAVLFLLLR 375
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
7-373 |
3.05e-15 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 77.01 E-value: 3.05e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 7 RNDSTSSYRWVILLIATISQTFATFVTYGIGPLASLWQQVHHLSQFQTGLLVSAVNIGPIFSMLPFGNLMDRYGERWIVG 86
Cdd:TIGR00895 7 RKQPLSRYQWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 87 VGSVFLGASMLLAYPVTNYTYLVVILLFVGIWYGTAQPGGSKAIVKWFPPQRRGLAMGIRQTGIPIGGALASSTLPFFFY 166
Cdd:TIGR00895 87 WSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIP 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 167 KYGLPSVILVQAIVTISGGLLFILFYRE---------------------------------ERSTIQKIETASFLTkLKQ 213
Cdd:TIGR00895 167 VFGWRSLFYVGGIAPLLLLLLLMRFLPEsidflvskrpetvrrivnaiapqmqaeaqsalpEQKSTQGTKRSVFKA-LFQ 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 214 IRRNDSLyPIFLIGITMMSLQMVLVSHLMSYLTNEVHTNLHHAGTLLSVVLLGGMIGRILLAWTSDNIfkgNRVIPLQIT 293
Cdd:TIGR00895 246 GKTARIT-VLLWLLYFMLLVGVYFLTNWLPKLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRL---GPRVTALLL 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 294 IGITILLLLCMSFvmpYITFWLLVILCFFLGFFAIGWFSLFIVLVSERSDPQFIGLTVSFALTLNQFAIVLAPALFGILV 373
Cdd:TIGR00895 322 LLGAVFAVLVGST---LFSPTLLLLLGAIAGFFVNGGQSGLYALMALFYPTAIRATGVGWAIGIGRLGAIIGPILAGYLL 398
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
16-397 |
1.43e-14 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 74.53 E-value: 1.43e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 16 WVILLIATISqTFATFVtygIGP-LASLWQQVHHLSQFQTGLLVSAVNIGPIFSMLPFGNLMDRYGERWIVGVGSVFLGA 94
Cdd:cd17473 2 ITLLLASTLT-VMAGAA---IAPaLPAIAQHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGI 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 95 SMLLAYPVTNYTYLVVILLFVGIWYGTAQPGGSKAIVKWFPPQRRGLAMGIRQT--------GIPIGGALA--SSTLPFF 164
Cdd:cd17473 78 GGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAamslggvvFLLLGGALAeiGWRAPFL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 165 FYKYGLPSVILVqaivtisggllfILFYREERSTiqKIETASFLTKLKQIRRNDSLYPIFLIGITMMSLQMVLVSHLMSY 244
Cdd:cd17473 158 VYLLALPVLILV------------LLFLPEPARK--SKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFL 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 245 LTNEVHTNLHHAGTLLSVVLLGGMIGRILLAWTSDNIFKGNRVIPLQITIGITILLLLCMSFVmpyitfWLLVILCFFLG 324
Cdd:cd17473 224 LQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGL------WVVLLGAILAG 297
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1098108237 325 FFAIGWFSLFIVLVSERSDPQFIGLTVSFALTLNQFAIVLAPALFGILVDYLHSYAAPFSILALLIALSGIWL 397
Cdd:cd17473 298 LGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVL 370
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
19-398 |
1.71e-14 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 74.60 E-value: 1.71e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 19 LLIATISQTFATFVTYGIGPLASLWQQVHHLSQFQTGLLVSAVNIGPIFSMLPFGNLMDRYGERWIVGVGSVFLGA-SML 97
Cdd:cd17341 1 LHLSWLSFFLGFMVWFLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIpLLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 98 LAYPVTNYTYLVVILLFVGIwYGTAQPGGSKAIVKWFPPQRRGLAMGIRQTGIPIGGALASSTLPFFF-------YKYGL 170
Cdd:cd17341 81 LALAVSSYWGLLVLGFLLGF-AGANFASGQPWASFWFPKEKIGGAAGGIAGAGNMGVAVSQLLAPLIAgaivfdgGFVGW 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 171 PSVILVQAIVTISGGLLFILFYREerSTIQKIETASFLTKLKQIRRNDSLYPIFLIGITMMSLQMVLVSHLMSYLTNEVH 250
Cdd:cd17341 160 RNAFFVPGILLAIAAVLVLLFGDD--LPTGKASALEFLKVQLAVLKNYRTWILSLLYGVTFGSFVGFSNVLPTYFKTRFG 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 251 TNLHHAGTLLSVVLLGGMIGRILLAWTSDniFKGNRVIPLQITIGITILLLLC-MSFVMPYITFWLLVILCFFLGFFAIG 329
Cdd:cd17341 238 LPLVTAGILAALFPLAGALARPAGGWLSD--RFGGRRRLWWLFIVMTIGAALLsLSLPTSGTNLVLFLALFVALGLGAGA 315
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1098108237 330 WFSLFIVLVSERSdPQFIGLTVSFALTLNQFAIVLAPALFGILVDYLHSYAAPFSILALLIALSGIWLT 398
Cdd:cd17341 316 GNGSVFRMVPFIF-RRELGAVTGLVGAIGGLGGFFLPLLFGSSALMTGSGVGAFSLFGVLAVACTLLVW 383
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
15-398 |
3.75e-14 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 73.60 E-value: 3.75e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 15 RWVILLIATISQTFATFVTYGIGPLASLWQQVHHLSQFQTGLLVSAVNIGPIFSMLPFGNLMDRYGERWIVGVGSV-FLG 93
Cdd:cd17314 1 RWFVLYVSFLLSAMSTGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGImVLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 94 ASMLLAYPVTNYTYLVVILLFVGIWYGTAQPGGSKAIVKWFPpQRRGLAMGIRQTGIPIGGALASSTLPFFFYKYGLPS- 172
Cdd:cd17314 81 GYTYLSYVFNSFPLSYACFVFIGAGTGILYGSAVLVTTQYFP-DTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALv 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 173 ---VILVQAIVTISGGLLFILFYREERSTIQ----KIETASFLTKLKQIRRNDSLYPIFLIGITMMSLQMVLVSHLMSYL 245
Cdd:cd17314 160 ytiLGILAAIVLSVVSLLGFKEPPDNQARLHvqkkKTQTMGEIFRDKVFWILFIAIFLVLIGGFLFIANMASLVRSLQLD 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 246 TNEVHTnlhhagTLLSVVLLGGMIGRILLAWTSDniFKGNRVIPLQITIGITILLLLCMSFVMPYITFWLLVILCFFlGF 325
Cdd:cd17314 240 APSFVT------KLMSIYGLFNAFGRLLWGIVAD--FFGGRLSTLSILLTILGLGLCAFLFLLKMTPVGLVLTGSLL-GF 310
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1098108237 326 FAIGWFSLFIVLVSERSDPQFIGLTVSFALTLNQFAIVLAPALFGILVDYLHSYAAPFSILALLIALSGIWLT 398
Cdd:cd17314 311 SYGGLFTVYPATVSTVFGTESFATLYGILLFAPAIGSILGPMLGAKFYDRTPSYISAVYIYAVIVFLASAILL 383
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
19-399 |
3.64e-13 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 70.70 E-value: 3.64e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 19 LLIATISQTFATFVTYgigplasLWQQVHHLSQFQTGLLVSAVNIGPIFSMLPFGNLMDRYGERW-----IVGVGSVFLG 93
Cdd:COG2211 20 LGLNLAFGLLSAYLLY-------FYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWgrrrpWILIGAIPLA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 94 ASMLLAY------PVTNYTYLVVILLFVGIWYGTAQ-PGGSKAIVKWFPPQRRGLAMGIRQTGIPIGGALASSTLPFFFY 166
Cdd:COG2211 93 LSFVLLFtapdlsPTGKLIYALVTYLLLGLAYTLVNiPYSALGAELTPDYEERTRLSSWRFAFAGLGGLLASVLPPPLVA 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 167 KYGLPSVILVQAIVTISGGLLFILFY-----REERSTIQKiETASFLTKLKQIRRNDSLYPIFLIGITMMSLQMVLVSHL 241
Cdd:COG2211 173 AFGGDAALGYRLTALIFAVLGLLAFLltffgTKERPVPEE-EKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALL 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 242 MSYLTNEVHTNLHHAGTLLSVVLLGGMIGRILLAWTSDNIfkgNRVIPLQITIGITILLLLCMSFVMPyITFWLLVILCF 321
Cdd:COG2211 252 LYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRF---GKKKAFIIGLLLAALGLLLLFFLGP-GNLWLLLVLAA 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 322 FLGFFAIGWFSLFIVLVSERSDPQFI-------GLTVSFALTLNQFAIVLAPALFGILVDYLH-------SYAAPFSILA 387
Cdd:COG2211 328 LAGIGLGAILVLPWAMLADVVDYDEWktgrrreGLYFGIFTFAIKLGQALAGALAGLLLALFGyvagaaqSPSALTGIRL 407
|
410
....*....|..
gi 1098108237 388 LLIALSGIWLTI 399
Cdd:COG2211 408 LFFLLPAVLLLL 419
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
48-399 |
4.45e-13 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 69.91 E-value: 4.45e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 48 HLSQFQTGLLVSAVNIGPIFSMLPFGNLMDRYGERWIVGVGSVFLGASMLLAYPVTNYTYLVVILLFVGIWYGTAQPGGS 127
Cdd:cd17474 30 GASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGLGPLAL 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 128 KAIVKWFPPQRRGLAMGIRQTGIP--------IGGALASSTLPFFFYKYGLPSVIlvqaivtisgGLLFILFYREERSTI 199
Cdd:cd17474 110 TLIGDLFEGGERAKAMGLYEAALGlgiavgplLGGLLAAISWRYPFFLLAALIPV----------AFLAILFLLPEPKEK 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 200 QKIETASFLTKLKQIRRNDSLYPIFLIGITMMSLQMVLVSHLMSYLTNEVHTNLHHAGTLLSVVLLGGMIGRILLAWTSd 279
Cdd:cd17474 180 AKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLL- 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 280 nifkGNRVIPLQITIGITILLLLCMSFVMPYITFWLLVILCFFLGFFAIGWFSLFIVLVSERSDPQFIGLTVSFALTLNQ 359
Cdd:cd17474 259 ----KKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRF 334
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 1098108237 360 FAIVLAPALFGILVDYLhSYAAPFsILALLIALSGIWLTI 399
Cdd:cd17474 335 LGQAVGPLLFGLLLEIF-GLSAPF-LVGAAIALAAAVLLA 372
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
44-400 |
7.34e-13 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 69.58 E-value: 7.34e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 44 QQVHHLSQFQTGLLVSAVNIGPIFSMLPFGNLMDRYGERWIVGVGsVFLGASMLLAYPVTNYTYLVVILLFV-----GIW 118
Cdd:cd17345 30 IEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIG-LILSAIINILIGFVPSATSSVGLMFIllflnGWF 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 119 YGTAQPGGSKAIVKWFPPQRRGLAMGIRQTGIPIGGALASST----LPFFFY-----KYGLPSVI-LVQAIVTI------ 182
Cdd:cd17345 109 QGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLaglgLAIFGDgwwrgAFIFPAIIaIIVAVIVLflgkdt 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 183 --SGGLLFILFYREERSTIQKIETASF-LTK----LKQIRRNDSLYPIFLIGITMMSLQMVLVSHLMSYLTNEVHTNLHH 255
Cdd:cd17345 189 peSEGLPPIEEYKGDYPEEADGEEEEQeLSAweifVKYVLKNKLLWYIAIANVFVYLVRYGILDWAPTYLSEVKGFSKAQ 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 256 AGTLLSVVLLGGMIGRILLAWTSDNIFKGNRVIPLQITIGITILLLLCMSFVMPYitfWLLVILCFFLGFFAIGWFSLFI 335
Cdd:cd17345 269 AMWAFSLFEWAAIPGTLLAGWLSDKLFKGRRAPTGIIFMILVIVALIVYWLAPNV---LVDLIALIALGFLIYGPVMLIG 345
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1098108237 336 VLVSERSDPQFIGLTVSF-ALTLNQFAIVLAPALFGILVDYlHSYAAPFSILALLIALSGIWLTIT 400
Cdd:cd17345 346 LQALELVPKKAAGTAAGLtGLFGYLGGSVLATALIGIIVDH-FGWNGGFIVLLASCILAIIFLALV 410
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
48-395 |
1.66e-12 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 68.01 E-value: 1.66e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 48 HLSQFQTGLLVSAVNIGPIFSMLPFGNLMDRYGERWIVGVGSVFLGASMLLAYPVTNYTYLVVILLFVGIWYGTAQPGGS 127
Cdd:cd17316 32 GLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGAS 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 128 KAIVKWFPPQRRGLAMGIRQTGIPIGGALASstLPFFFYKYGLPSVILVQAIVTISGGLLFILFYreerstiqkietasf 207
Cdd:cd17316 112 TYVAEFAPSKRRGFALGLLQSGWALGALLAA--LVASLLIPLLSGDWGWRILFLIGALPALLALL--------------- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 208 ltklkqIRRNDSLypIFLIGITMMSLQMVLVSHLMSYLTNEVHTNLHHAGTLLSVVLLGGMIGRILLAWTSDNIfkGNRv 287
Cdd:cd17316 175 ------LRRRTLL--LILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRI--GRK- 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 288 iPLQITIGITILLLLCMSFVMPYITFWLLVILCFFLGFFAIGWFSLFIVLVSERSDPQFIGLTVSFALTLNQFAIVLAPA 367
Cdd:cd17316 244 -KTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPP 322
|
330 340
....*....|....*....|....*...
gi 1098108237 368 LFGILVDYLHSYAAPFSILALLIALSGI 395
Cdd:cd17316 323 LIALLLASTGGTGVPALILALLAIVALI 350
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
24-395 |
2.28e-12 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 68.02 E-value: 2.28e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 24 ISQTFATFVTYGIGPLASLW-QQVHHLSQFQTGLLVSAVNIGPIFSMLPFGNLMDRYGERWIVGVGSVFLGASMLLAYPV 102
Cdd:cd17329 6 IGSFLNRLGFFMVWPFMAIYlHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 103 TNYTYLVVILLFVGIWYGTAQPGGSKAIVKWFPPQRRGLAMGIRQTGIPIG---GALASStlpfFFYKYGLPSVILVQAI 179
Cdd:cd17329 86 HSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGvaiGPLLGG----LLLLYSFRLLFLAAAV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 180 VTISGGLLFILFYREERSTIQKIETASFLTKLKQIRRNDSLYPIFLIGITMMSLQMVLVSHLMSYLTNEVHTNLHHAGTL 259
Cdd:cd17329 162 LFLLAALVLLFLLPETRPKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 260 LS-----VVLLGGMIGRILLAWTsdnifkgnrvIPLQITIGItILLLLCMSFVMPYITFWLLVILCFFLGFFAIGWFSLF 334
Cdd:cd17329 242 LAlnallIVLLQFPVARLVERFR----------LRKILMIGI-LLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAV 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1098108237 335 IVLVSERSDPQFIGLTVSFALTLNQFAIVLAPALFGILVDYlHSYAAPFSILALLIALSGI 395
Cdd:cd17329 311 QTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDL-LGPGLPWLILAALGLIAAA 370
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
57-397 |
4.42e-12 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 67.26 E-value: 4.42e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 57 LVSAVNIGPIFSMLPF-GNLMDRYGERWI-----VGVGSVFLGASMLLAYPVTNYTYLVVILLFVGIWYGTAQPGGSKAI 130
Cdd:cd06173 38 LVLAAFFLPFLLFSPFaGVLADRFDRRRLliladLLRALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPARQALL 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 131 VKWFPPQRRGLAMGIRQTGIPIGGALASSTLPFFFYKYGLPSVILVQAIV-TISGGLLFILFYREERSTIQK--IETASF 207
Cdd:cd06173 118 PELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSfLLSALLLLFIRRPPPAAPGESssLLLRDL 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 208 LTKLKQIRRNDSLYPIFLIGITMMSLQMVLVSHLMSYLTNEVHTNLHHAGTLLSVVLLGGMIGRILLAWTSDNIFKGNRV 287
Cdd:cd06173 198 REGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLL 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 288 IPLQITIGITiLLLLCMSFVmpyitFWLLVILCFFLGFFAIGWFSLFIVLVSERSDPQFIGLTVSFALTLNQFAIVLAPA 367
Cdd:cd06173 278 LIGALLLGLA-LLVLGLSPS-----LWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGAL 351
|
330 340 350
....*....|....*....|....*....|
gi 1098108237 368 LFGILVDyLHSYAAPFSILALLIALSGIWL 397
Cdd:cd06173 352 LAGLLAD-ALGLSAVFLLAGALLLLAALLL 380
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
16-196 |
4.77e-12 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 66.82 E-value: 4.77e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 16 WVILLIATISQTFATFVTYGIGP-LASLWQQVHHLSQFQTGLLVSAVNIGPIFSMLPFGNLMDRYGER--WIVGVGSVFL 92
Cdd:COG2271 179 LLRFWLLALAYFLVYFALYGFLTwLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrkLVLAIGLLLA 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 93 GASMLLAYPVTNYTYLVVILLFVGIWYGTAQPGGSKAIVKWFPPQRRGLAMGIRQTGIPIGGALASSTLPFFFYKYGLPS 172
Cdd:COG2271 259 ALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQA 338
|
170 180
....*....|....*....|....
gi 1098108237 173 VILVQAIVTISGGLLFILFYREER 196
Cdd:COG2271 339 AFLLLAALALLAALLALLLLRETR 362
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
33-397 |
5.51e-12 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 66.94 E-value: 5.51e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 33 TYGIGPLASLWQqvhhLSQFQTGLLVSAVNIGPIFSMLPFGNLMDRYGERWIVGVGSVFLGASMLLAYPVTNYTYLVVIL 112
Cdd:cd17371 19 GLVLPALIAEFG----LDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILR 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 113 LFVGIWYGTAQPGGSKAIVKWFPPQRRGLAMGIRQTGIPIGGALASSTLPFFFykyGLPSVILVQAIVTISGGL--LFIL 190
Cdd:cd17371 95 ALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLF---PLLPPEIAWRVLFLLGALpaLLVL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 191 FYREERStiqkiETASFLTKlKQIRRNDSLYPIFLIGITMMSLQMVLVSHLM----------------SYLTNEVHTNLH 254
Cdd:cd17371 172 FIRRFVK-----EPPQWQAA-RAARRHFADRPSLRELFSPPLLRTTLLASLLatgalggyygittwlpSYLTGERGLSFE 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 255 HAGTLLSVVLLGGMIGRILLAWTSDNIFKGNRVIPLQITIGITILLllcmsfVMPY-ITFWLLVILCFFLGFFAIGWFSL 333
Cdd:cd17371 246 GSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFALGSAISILL------YFFLpLSPTLILILGFPLGFFASGPFSG 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1098108237 334 FIVLVSERSDPQFIGLTVSFALTLNQFAIVLAPALFGILVDY--LHSYAAPFSILALLIALSGIWL 397
Cdd:cd17371 320 MGAYLTELFPTAVRATAQGFCYNVGRIIGALFPFLVGFLATSgsLGTAIAVFAAVYYIAGLVLALL 385
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
5-301 |
5.74e-11 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 62.91 E-value: 5.74e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 5 KTRNDSTSSYRWVILLIATISQTFATFVTYGIGPLASLWQQVHHLSQFQTGLLVSAVNIGPIFSMLPFGNLMDRYGERWI 84
Cdd:COG0477 2 SSTDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 85 VGVGSVFLGASMLLAYPVTNYTYLVVILLFVGIWYGTAQPGGSKAIVKWFPPQRRGLAMGIRQTGIPIGGALASSTLPFF 164
Cdd:COG0477 82 LLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 165 FYKYGLPSVILVQAIVtisGGLLFILFYREERSTIQKIETASFLTKLKQIRRNDSLYPIFLIGITMMSLQMVLVSHLMSY 244
Cdd:COG0477 162 VAALGWRWIFLINAPL---GLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAA 238
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 1098108237 245 LTNEVHTNLHHAGTLLSVVLLGGMIGRILLAWTSDNIFKGNRVIPLQITIGITILLL 301
Cdd:COG0477 239 LLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
48-398 |
5.88e-11 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 63.89 E-value: 5.88e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 48 HLSQFQTGLLVSAVNIGPIFSMLPFGNLMDRYGERWIVGVGSVFLG-ASMLLAYpvTNYTYLVVILLFV-GIWYGTAQPG 125
Cdd:cd17343 34 GLDKSDLGLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGlTTVAFSG--SSSVWVFSILWFLnGLAQGLGWPP 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 126 GSKAIVKWFPPQRRGLAMGIRQTGIPIGGALASSTLPFFFYKYGLPSVILVQAIVTISGGLLFILFYREERS--TIQKIE 203
Cdd:cd17343 112 CAKILRKWFSPSQFGTWWSVLSTSMNLAGSLGPILATLLALSYGWRSTLSISGTVAVVMSVVCLLFIKNEPSdvGLNNIE 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 204 TASFLTKLKQIRRNDS-----LYPIFLIGITMMSLQMVLVSHLMS-----YLTNEVHTNLHHAGTLLSVVLLGGMIGRIL 273
Cdd:cd17343 192 EEESKGKKKKSPRGEStlkelLLSPFLWLLSLGYLVVFGVKTAVTdwgqlFLIQDKGQSALTGSSFMSSLEVGGFVGSIA 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 274 LAWTSD-------NIFKGNRVIPLQI--TIGITILLLLCMSFVMPYITFWLLVILCFFLGFFAIGWFSLFIVLVSERSDP 344
Cdd:cd17343 272 AGYLSDwavakhgSSSRGNPRMPLALvfMAGLTVSLHLFRVHITSDSSELFILLLGFLIGFSLYGPIAIFGVIANESAPS 351
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1098108237 345 QFIGLTVSFALTLNQFAIVLAPALFGILVDyLHSYAAPFSIL--ALLIALSGIWLT 398
Cdd:cd17343 352 HLCGTSHAIVALAANVGGVLAGLPFSYIAK-HYDWRTAFLLLeiLCAITVVILFLL 406
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
73-397 |
1.31e-10 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 62.42 E-value: 1.31e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 73 GNLMDRYGERWIVGVGSVFLGASMLLAYPVTNYTYLVVILLFVGIWYGTAQPGGSKAIVKWFPPQRRGLAMGIRQTGIPI 152
Cdd:cd17488 59 GLMSDRSNPRYFMGIGLIATGIINILFGFSSSLWAFAVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNI 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 153 GGALASSTLPFFFYKYGLPSVILVQAIVTISGGLLFILFYREERSTIQKIETASFLTKLKQIRRNDSlypifligitmms 232
Cdd:cd17488 139 GGALIPILTGFAALTYGWRAGMYVPGIIAILMGIVLCWRLRDRPPYIWLLAFCYVLVYVVRTAINDW------------- 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 233 lqmvlvSHLmsYLTNEVHTNLHHAGTLLSVVLLGGMIGRILLAWTSDNIFKGNRViPLQITIGITILLLLCMSFVMPYIT 312
Cdd:cd17488 206 ------GNL--YLSETHGYSLVKANSAVSLFEVGGLIGALVAGWGSDKLFKGNRG-PMNLIFALGLLVSVGALWLVPVHS 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 313 FWLLVILCFFLGFFAIGWFSLFIVLVSERSDPQFIGLTVSFALTLNQFAIVLAPALFGILVDYLHsYAAPFSILALLIAL 392
Cdd:cd17488 277 YWLLATCFFTIGFFVFGPQMLIGMAAAECSHKDAAGSATGFVGLFAYLGAALAGYPLAKVIESWG-WSGFFIVISIAAAI 355
|
....*
gi 1098108237 393 SGIWL 397
Cdd:cd17488 356 SGLLL 360
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
11-165 |
7.11e-10 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 60.26 E-value: 7.11e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 11 TSSYRWVILLIATISQTFATFVTYgigpLASLWQQVHHLSQFQTGLLVSAVNIGPIFSMLPFGNLMDRYGERWIVGVGSV 90
Cdd:cd17321 167 ARTFSGAVLAAFLLGAALGGLLFL----LPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLL 242
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 91 FLGASMLLAYPV---TNYTYLVVILLFVGIWYGTAQPGGSKAIVKWFPPQRRGLAMGI----RQTGIPIGGALASSTLPF 163
Cdd:cd17321 243 LTAVGLLLLALLgadSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGIlntaRQLGGALGVALLGALLTA 322
|
..
gi 1098108237 164 FF 165
Cdd:cd17321 323 GL 324
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
73-329 |
1.29e-09 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 59.72 E-value: 1.29e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 73 GNLMDRYGERWIVGVGSVFLGAsMLLAYPVTNYTYLVVILLFVGIWY-GTAQPGGSKAIVKWFPPQRRGLAMGIRQTGIP 151
Cdd:PRK11663 79 GIVSDRSNARYFMGIGLIATGI-INILFGFSSSLWAFALLWVLNAFFqGWGWPVCAKLLTAWYSRTERGGWWAIWNTAHN 157
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 152 IGGALASSTLPFFFYKYGLPSVILVQAIVTISGGLLFILFYREERSTI----------------QKIETASfLTKLKQIR 215
Cdd:PRK11663 158 VGGALIPLVVGAIALHYGWRYGMMIAGIIAIVVGLFLCWRLRDKPQAMglpsvgewrhdalelaQQQEGAG-LSRKEILT 236
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 216 RndslYPIFLIGITMMSLQMVLVSHLMS--------YLTNEVHTNLHHAGTLLSVVLLGGMIGRILLAWTSDNIFKGNRV 287
Cdd:PRK11663 237 K----YVLLNPYIWLLSFSYVLVYVVRAaindwgnlYMSETLGVDLVTANSAVSMFELGGFIGALVAGWGSDKLFNGNRG 312
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 1098108237 288 iPLQITIGITILLLLCMSFVMPYITFWLLVILCFFLGFFAIG 329
Cdd:PRK11663 313 -PMNLIFAAGILLSVGSLWLMPFASYVMQAACFFTIGFFVFG 353
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
38-320 |
1.30e-09 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 59.76 E-value: 1.30e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 38 PLASLWQQVHHLSQFQTGLLVSAVNIGPIFSMLPFGNLMDRYGERWIVGVGSVFLGASMLLAYPvtNYTYLVVILLFVGI 117
Cdd:TIGR00894 62 ELDNIKNPNFKWSGALQGLILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPW--AAGGGIALVVFCRV 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 118 WYGTAQ----PGGSKAIVKWFPPQRRGLAMGIRQTG--------IPIGGALASSTLpfffykyGLPSVILVQAIVTISGG 185
Cdd:TIGR00894 140 IQGLAQgsvsPATHKIIVKWAPPKERSRLLGMSTSGfqlgtfifLPISGWLCESWG-------GWPMIFYVFGIVGCAWS 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 186 LLFILFYREERST---IQKIETASFLTKLKQirRNDSLYPIFLIGITMMSLQMV-----------LVSHLMSYLTNEVHT 251
Cdd:TIGR00894 213 LLWFVFPADDPSIhpcISKFEKKYINSSLQG--QKGSTRQSLPIKAIPKSLPVWaiwfaifghfwLYTILPTYLPTFISW 290
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 252 NLHHAGTL---------LSVVLLGGMIGRILLAWTSDNIFKgnRVIPLQITIGITILLLLCMSFVMPYIT---FWLLVIL 319
Cdd:TIGR00894 291 VLRVSGKEngllsslpyLFAWLCSIFAGYLADFLKSSKTLS--LTAARKIFNGIGGLGPGIFAYALPYLSaafYLTIIIL 368
|
.
gi 1098108237 320 C 320
Cdd:TIGR00894 369 T 369
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
12-191 |
4.04e-09 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 57.99 E-value: 4.04e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 12 SSYRWVILLIATISQTFATFVTYGIGPLASLWQQVHHLSQfqTGLLVSAVNIGPIFSMLPFGNLMDRYGERWIVGVGSVF 91
Cdd:cd17489 189 RRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERGISN--AGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLL 266
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 92 LGASMLLAYPVTNYTYLVVILLFVGIWYGTAQPGGSKAIVKWFPPQRRGLAMGIRQTGIPIGGALASSTLPFFFYKYGLP 171
Cdd:cd17489 267 LALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYR 346
|
170 180
....*....|....*....|
gi 1098108237 172 SVILVQAIVTISGGLLFILF 191
Cdd:cd17489 347 AMFLLAAVVVLLALVLYIFL 366
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
44-397 |
7.17e-09 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 57.25 E-value: 7.17e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 44 QQVHHLSQFQTGLLVSAVNIGPIFSMLPFGNLMDRYGERWIVGVGSVFLGASMLLAYPVTNYTYLVVILLFVGIW---YG 120
Cdd:cd17328 26 QSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGeasYS 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 121 TAQPGgskAIVKWFPPQRRGLAMGIRQTGIPIGGAL--------ASSTLP--FFFYKYGLPSVILVqaivtisggLLFIL 190
Cdd:cd17328 106 PIAPT---IIADLFPKEKRTRALGVFYFAIPLGSGLgyvvgglvAQATGGwrWAFRVTGVLGVLLA---------ILLLL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 191 FYRE------ERSTIQKIETASFLTKLKQIRRNdslyPIFLIgitmMSLQMVLVS-----------HLMSYLTNEVHTNL 253
Cdd:cd17328 174 FVREpprgaaEGGVMAKSTATSFLADLKALAKN----PSFIL----STLGFTAVSfvtgalafwapTFFLRAFGVGDLSS 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 254 HHAGTLLSVV-----LLGGMIGRILLAWTSDNIFKGNRVIPLQITIGITILLLLCMSFvmpYITFWLLVILCFFLG-FFA 327
Cdd:cd17328 246 ADVGLIFGAItciagVLGVLLGGILADRLRRKTPRADPLVCAVGLLAAAPFLFLALVL---ALSNLLLAWVLLFLGeFLL 322
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1098108237 328 IGWFSLFIVLVSERSDPQFIGLTVSFALTLNQ-FAIVLAPALFGILVDYLH----SYAAPFSIL--ALLIALSGIWL 397
Cdd:cd17328 323 SLNWAPVFAILLYVVIPTRRSTASAIQILLSHlLGDAGSPYLIGLISDLLRqnkdSPLAEAASLqyALLLCSFVLVL 399
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
27-397 |
4.81e-08 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 54.63 E-value: 4.81e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 27 TFATFVTYGI-----GPLASLWQQVHHLSQFQTGLLVSAVNIGPIFSMLPFGNLMDRYGERWIVGVGSVFLGASMLLAYP 101
Cdd:cd17333 1 LYISFFSNGLtdallGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 102 VTNYTYLVVILLFVGIWYGTAQPGGSKAIVKWFpPQRRGLAMGIRQT--------GIPIGGALASSTLPFFFYKYGLPSV 173
Cdd:cd17333 81 TPSIYLFVVLMFLAGLGAGILDTGANTFVGALF-EESSATRLNVLHGffglgaliGPLIATSLLTSELSWSWAYLIIGLI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 174 ILVQAIVTisgglLFILFYREERSTIQKIETASFLTKLKQIRRNDSLYPIFLIGITMMSLQMVLVSHLMSYLTNEVHTNL 253
Cdd:cd17333 160 YLLLAILI-----LLTLFPELPSARNPQQSVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSD 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 254 HHAGTLLSVVLLGGMIGRILLAWTSDNIfKGNRVIPLQITIGITILLLLCMSFvmpyiTFWLLVILCFFLGFFAIGWFSL 333
Cdd:cd17333 235 GLAGYLLSGFWVGITIGRLLGGPISRRI-KPHTLLVLSGSGALLGLLILLLAP-----TLVVGLVATALLGLFMAALFPT 308
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1098108237 334 FIVLVSERSdPQFIGLTVSFALTLNQFAIVLAPALFGILVDYLHSYAAPFSILALLIALSGIWL 397
Cdd:cd17333 309 ILSLGISNL-PYAKGKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLLITILYAIIFVLAL 371
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
223-397 |
5.21e-08 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 54.21 E-value: 5.21e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 223 IFLIGITMMSLQMVLVSHLMSYLTNEVHTNLHHAGTLLSVVLLGGMIGRILLAWTSDNIfkgNRVIPLQITIGITILLLL 302
Cdd:COG2814 14 ALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRF---GRRRVLLLGLLLFALGSL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 303 CMSFVMpyiTFWLLVILCFFLGFFAIGWFSLFIVLVSERSDPQFIGLTVSFALTLNQFAIVLAPALFGILVDYLhSYAAP 382
Cdd:COG2814 91 LCALAP---SLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF-GWRWV 166
|
170
....*....|....*
gi 1098108237 383 FSILALLIALSGIWL 397
Cdd:COG2814 167 FLVNAVLALLALLLL 181
|
|
| MFS_DIRC2 |
cd17397 |
Disrupted in renal carcinoma protein 2 of the Major Facilitator Superfamily of transporters; ... |
14-371 |
5.83e-08 |
|
Disrupted in renal carcinoma protein 2 of the Major Facilitator Superfamily of transporters; Disrupted in renal carcinoma protein 2 or disrupted in renal cancer protein 2 (DIRC2), encoded by the SLC49A4 gene, was initially identified as a breakpoint-spanning gene in a chromosomal translocation associated with the development of renal cancer. It is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. DIRC2 belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340955 [Multi-domain] Cd Length: 381 Bit Score: 54.23 E-value: 5.83e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 14 YRWVILLIATISQTFATFVTYGIGPLASLWQQVHHLSQFQTGLLVSAVNIGPIFSMLPFGNLMDRYGERWIVGVGSVFLG 93
Cdd:cd17397 1 RRWYILLVFSLLAFTQGAVWNTWGPIADSAKPAFGWSDSDIALLANWGPIGFVPTFFFMAWLMDVKGLRIAVLSSAFLVA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 94 ASMLL-AYPVTNY--TYLVVI-LLFVGIWYGTAQPGGSKAIVKWFPPQRRGLAMGIRQTGIPIGGALA--SSTLPFFFYK 167
Cdd:cd17397 81 AGTGLrCIPVPNHlaTWLIHIgQFLNGLAGPVAMAAAPFLSATWFPPNQRATATAIASIFNYLGGAASflIGPLVLMYLE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 168 YGLPSVIlvqaivtisggLLFILFYREER-----STIQKIETASFLTKLKQIRRNDSLYPIFLIGITMMSLQMVLVSHLM 242
Cdd:cd17397 161 FGWSALI-----------FLAMLIYFPSKpptppSVSASTQRLSYKSGILSLLKNKRFWLIALAYGIPTGVYAGWSGVLD 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 243 SYLTNeVHTNLHHAGTLLSVVLLGGMIGRILLAWTSDNIFKGNRVIPLQITIGITILLLLCMSFVMPYITF--WLLVILC 320
Cdd:cd17397 230 VNLTP-FGVSQVEAGWIGFYSTVAGCVGGIIVGRFADRFGGRMKLILLLLFSGATGSFLWFTLICLKLLPFstVSLYTSC 308
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1098108237 321 FFLGFFAIGWFSLFIVLVSERSDPQFIGLTVSFALTLNQFAIVLAPALFGI 371
Cdd:cd17397 309 ILLGVFLNGSVPLFYELAVEAAYPVPEGITSGVLTFLNNVFGLVFLLILII 359
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
18-325 |
6.45e-08 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 54.23 E-value: 6.45e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 18 ILLIATISQTFATFVTYGIGPLAS-LWQQVHHLSQFQTGLLVSAVNIGPIFSMLPFGNLMDRYGER-WIVGVGSVFLGAS 95
Cdd:TIGR00886 2 NLFFSWFGFFLSFLVWFAFSPLAVfLIKDDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRyTTALSLLLLAIPC 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 96 MLLAYPVTNYTYLVVILLFVGIWYGTAQPgGSKAIVKWFPPQRRGLAMGIRQTGIPIGGALASSTLP----FFFYKYGLP 171
Cdd:TIGR00886 82 LWAGLAVQSYSVLLLIRLFIGIAGGSFAS-CMPWISFFFPKKIQGTALGLAAGWGNMGGGVAQFVMPpiigSLIFGGGQP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 172 -------SVILVQAIVTISGGLLFILFYREERSTIQKIETASFLTKLKQIRRNDSLYPIFLIGITMMSlQMVLVSHLMSY 244
Cdd:TIGR00886 161 ahlawgwAFVIVPAGILLLPALLIFFVGADTPPGKPATGKLSFKEALKVFGNRHTWILALLYSVTFGS-FLGVSSIFAML 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 245 LTNEVHTNLHHAGTLLSVVLLGGMIGRILLAWTSDNIFkGNRVIPLQITIGITILLLLCMSFVMPY---ITFWLLVILCF 321
Cdd:TIGR00886 240 FKDQFGLSKVQAGAYASLGGFLGSLARPAGGAISDRLG-GARKLLMNFLGVAMGAFLVVLGLVSDGslaAFIVLFVALFF 318
|
....
gi 1098108237 322 FLGF 325
Cdd:TIGR00886 319 FAGA 322
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
48-397 |
1.84e-07 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 52.58 E-value: 1.84e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 48 HLSQFQTGLLVSAVNIGPIFSMLPFGNLMDRYGERWIVGVGSVFLGASMLLAYPVTNYTYLVVILLFVGIWYGTAQPGGS 127
Cdd:cd17330 30 GASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNVSVAQA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 128 kAIVKWFPPQRRGLAMGIRQTGIPIGGALASSTLPFFFYKYGLPSVILVQAIVTISGgLLFILFYreerstiqkietasf 207
Cdd:cd17330 110 -YIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLN-LVLVLFF--------------- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 208 ltkLKQIRRndslypIFLIGITMMSLQMVLVSHLMSYLTNEVHTNLHHAGTLLSVVLLGGMIGRILLawtsdnIFKGNRV 287
Cdd:cd17330 173 ---LPPLRR------LLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLL------IPRLAKR 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 288 IPLQITIGITILLLLCMSFVMPYIT-FWLLVILCFFLGFFAIGWFSLFIVLVSERSDPQFIGLTVSFALTLNQFAIVLAP 366
Cdd:cd17330 238 LGERKLLRLGLLLAIIGLLLLPFASsVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGP 317
|
330 340 350
....*....|....*....|....*....|.
gi 1098108237 367 ALFGILVDYLhSYAAPFSILALLIALSGIWL 397
Cdd:cd17330 318 LLAGPLYSFL-GPGVPFLLAAGLLLIALFLL 347
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
27-191 |
2.03e-07 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 52.58 E-value: 2.03e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 27 TFATFVTYGIGP--LASLWQQVHHLSQFQTGLLVSAVNIGPIFSMLPFGNLMDRYGERWIVGVGSVFLGASMLLAYPVTN 104
Cdd:cd17473 206 AFLAMLLFYVIPiqLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASG 285
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 105 YTYLVVILLFVGIWYGTAQPGGSKAIVKWFPPQRRGLAMGIRQTGIpIGGALASSTLPFFFYKY--GLPSVILVQAIVTI 182
Cdd:cd17473 286 LWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAF-FLGQFLSPLVLGPLVNLtgGLSGAFLILGVLAL 364
|
....*....
gi 1098108237 183 SGGLLFILF 191
Cdd:cd17473 365 VLAIVLLLL 373
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
38-189 |
2.44e-07 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 52.16 E-value: 2.44e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 38 PLASLWQQVHHLSQFQTGLLVSAVNIGPIFSMLPFGNLMDRYGERWIVGVGSVFLGASMLLAYPVTNYTYLVVILLFVGI 117
Cdd:cd17370 220 AFLILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGL 299
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1098108237 118 WYGTAQPGGSKAIVKWFPPQRRGLAMGIRQTGIPIGGALASSTLPFFFYKYGLPSVILVQAIVTISGGLLFI 189
Cdd:cd17370 300 YMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLLL 371
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
21-189 |
3.19e-07 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 52.19 E-value: 3.19e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 21 IATISQTFATFVTYGIGPLASLW-QQVHHLSQFQTGLLVSAVNIGPIFSMLPFGNLMDRYGERWIVGVGSVFLGASMLL- 98
Cdd:cd17503 182 LGLLLSFLLGLGLFGAMFLLPLYlQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLl 261
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 99 --AYPVTNYTYLVVILLFVGIWYGTAQPGGSKAIVKWFPPQRRGLAMGI----RQTGIPIGGALASSTLPFFFYKYGLPS 172
Cdd:cd17503 262 afLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALfntiRQLGGSIGTALLATLLTNRTQFHHSRL 341
|
170
....*....|....*..
gi 1098108237 173 VILVQAIVTISGGLLFI 189
Cdd:cd17503 342 SELLAQQVQKQALIIAF 358
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
53-395 |
5.14e-07 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 51.50 E-value: 5.14e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 53 QTGLLVSAVNIGPIFSMLPFGNLMDRYGERW---IVGVGSVFLGASMLLAYPVTNYTYLVVILLFVGIWYGTAQPGGSKA 129
Cdd:pfam00083 47 LSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKsllIANVLFVIGAVLQGAAKGKWSVYQLIVGRVLVGIGVGGASVLAPMY 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 130 IVKWFPPQRRGLAMGIRQTGIPIGGALASSTlpFFFYKYGLPSV--ILVQAIVTISGGLLFILFY--------------- 192
Cdd:pfam00083 127 ISEIAPKKLRGALGSLYQLAITFGILLAYIF--GLGLNKTSNSDgwRIPLGLQLVPALLLIIGLLflpesprwlvekgrl 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 193 --------------------REERSTIQKIETASFLTKLKQIRRNDSLYPIFLIGITMMSLQMVLVSHLMSYLTNeVHTN 252
Cdd:pfam00083 205 eearevlaklrgvpdvdrelDEIKDSLEAGQEAEKASWKELFSTKTRRQRLLIGVMLQIFQQLTGINAIFYYSTT-IFEN 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 253 LHHAGTLLSVVLLGG--MIGRILLAWTSDNIfkGNRviPLQITIGITillLLCMSFVMPYITFWL-----------LVIL 319
Cdd:pfam00083 284 LGLSDSFLVTIIVGVvnFVFTFIAIFLVDRF--GRR--PLLLLGAAG---MAICFVILGIVALLGvsksdwagivaIVFI 356
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1098108237 320 CFFLGFFAIGWFSLFIVLVSERSDPQFIGLTVSFALTLNQFAIVLAPALFGILVDYLHSYAAPFSILALLIALSGI 395
Cdd:pfam00083 357 ALFIAFFAMGWGPVPWVIVSELFPLSVRSKAMALATAANWLANFLIGFLFPIITDAIGLGYTFFIFAGLLVLFIIF 432
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
50-192 |
5.34e-07 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 51.47 E-value: 5.34e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 50 SQFQTGLLVSAVNIGPIFSMLPFGNLMDRYGERWIVGVGsVFLGASMLLAYPV---TNYTYLVVILLFVGIWYGTAQPGG 126
Cdd:cd17318 54 SEKTQGIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYS-ILITALLTLLTPLaarGGYGALIVLRILQGLAQGVTFPAM 132
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1098108237 127 SKAIVKWFPPQRRGLAMGIRQTGIPIGGALASSTLPFFFYKYGLPSVILVQAIVtisgGLLFILFY 192
Cdd:cd17318 133 HALWAKWAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLCESLGWPSIFYIFGGL----GLLWCLLW 194
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
70-399 |
1.84e-06 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 49.52 E-value: 1.84e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 70 LPFGNLMDRYGERWIVGVGSVFLGASMLLAYPVTNYTYLVVILLFVGIwyGTAQPGGSKAIVKWFPPQRRGLAMGIrqTG 149
Cdd:cd17472 50 IPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGS--GAISSVVMALLADLTREENRTKAMAL--IG 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 150 IPIGGALASSTL--PFFFYKYGLPSVILVQAIVTISGglLFILFYREERSTIQKIETASFLTKLKQIRRNDSLYPIFLIG 227
Cdd:cd17472 126 ASIGIAFAISMVlgPLLAAHLGVSGLFLITAILSLVS--LLILLFFVPDPPKIVQISEKEKKKLKKLLKNKRLLRLDFSI 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 228 ITMMSLQMVLVSHLMSYLTNEVHTNLHHAGTLLSVVLLGGMIGRILLAWtSDNIFKGNRVIplQITIGITILLLLCMSFV 307
Cdd:cd17472 204 FILHFVLMAFFYILPLLLTQLGGGKGQLWKVYLPAILIGFILMVPFVIY-AEKKGKMKQVF--VSSILLIAVGFLLLLFA 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 308 MPYITFWLLVILCFFLGFFAIGwfSLFIVLVSERSDPQFIGLTVSFALTLNQFAIVLAPALFGILVDYLHSyaapFSILA 387
Cdd:cd17472 281 ATSLWLLIIGLIIFFIGFNLLE--ALLPSLVSKIAPKEYRGTAMGIYNTSQFLGSFLGGALGGLLWGLLGY----SSVFL 354
|
330
....*....|..
gi 1098108237 388 LLIALSGIWLTI 399
Cdd:cd17472 355 TILILALLWLLV 366
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
73-400 |
2.68e-06 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 49.19 E-value: 2.68e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 73 GNLMDRYGERWIVGVGSVFLGASMLLAYPVTNYTYLVVILLFVGIWYGTAqPGGSKAIVKWFPPQRRGLAMGIRQTGIP- 151
Cdd:cd17391 57 GRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGVFSGYV-PNATALIASQTPKEKSGWALGTLSTGVVa 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 152 -------IGGALASStlpfffykYGLPSVILVQAIVTISGGLLFILFYREERSTIQKIETASFLTKLKQIRRNDSLYPIF 224
Cdd:cd17391 136 gtligplLGGFLADL--------FGIRNVFFITGGLLFLAFLLTLFFVKEDFKPVEKKKMVSTKEVWNSVPNPSLLISLF 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 225 ----LIGITMMSLQMVLVSHLMSYLTNEVHTNLhHAGTLLSVVLLGGMIGRILLAWTSDNIfkGNRVIpLQITIGITILL 300
Cdd:cd17391 208 vttfIIQLANQSIEPILTLYIRQLMGDASNLAF-ISGLVFSATGVSSLLSAPRLGKLGDRI--GHHRI-LLGALLASALL 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 301 LLCMSFVMpyiTFWLLVILCFFLGFFAIGWFSLFIVLVSERSDPQFIGLTVSFALTLNQFAIVLAPALFGILVDYLhSYA 380
Cdd:cd17391 284 YIPQAFVQ---TPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHF-GYR 359
|
330 340
....*....|....*....|
gi 1098108237 381 APFSILALLIALSGIWLTIT 400
Cdd:cd17391 360 AVFVVTALLVLLNAIWSFIF 379
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
50-193 |
2.99e-06 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 49.09 E-value: 2.99e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 50 SQFQTGLLVSAVNIGPIFSMLPFGNLMDRYGERWIVGVGSVFLGASMLLaYPVTNYTYLVVILL---FVGIWYGTAQPGG 126
Cdd:cd17380 32 SKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLL-TPLLAYSSLPLLILsriLLGLGEGVHFPSM 110
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1098108237 127 SKAIVKWFPPQRRGLAMGIRQTGIPIGGALASSTLPFFFYKYGLPSVILVQAIVTISGGLLFILFYR 193
Cdd:cd17380 111 TSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGLLGLLWALVWLIYLP 177
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
48-191 |
3.81e-06 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 48.72 E-value: 3.81e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 48 HLSQFQTGLLVSAVNIGPIFSMLPFGNLMD-RYGERWIVGVGSVFLGASMLLAYPVTNYTYLVVILLFVGIWYGTAQPGG 126
Cdd:cd17474 230 GISPIIIGLLFAGWSVLLALGSLFVGRLLKkRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLL 309
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1098108237 127 SKAIVKWFPPQRRGLAMGIRQTGIPIGGALASSTLPFFFYKYGLPSVILVQAIVTISGGLLFILF 191
Cdd:cd17474 310 TTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
23-190 |
9.12e-06 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 47.57 E-value: 9.12e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 23 TISQTFATFVTYGIGP-LASLWQQVHHLSQFQTGLLVSAVNIGPIFSMLPFGNLMDRY---GERWIVGVGSVFLGASMLL 98
Cdd:cd17319 185 ALGYFGINYALYGLLTwLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLlrgARRLVIIIGLLLAAVGLLL 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 99 AYPVTNYTYLVVILLFVGIWYGTAQPGGSKAIVKWFPPQRRGLAMGIRQTGIPIGGALASSTLPFFFYKYG--LPSVILV 176
Cdd:cd17319 265 AYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGsyTAAFLFL 344
|
170
....*....|....
gi 1098108237 177 QAIVTISGGLLFIL 190
Cdd:cd17319 345 AAVALLAALLVLLL 358
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
15-191 |
1.44e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 46.84 E-value: 1.44e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 15 RWVILLIATISQTFATFVTYGIGPLASLWQQVHHLSQFQTGLLVSAVNIGPIFSMLPFGNLMDRYGERWIVGVGSVFLGA 94
Cdd:cd06173 207 SPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGL 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 95 SMLLAYPVTNYTYLVVILLFVGIWYGTAQPGGSKAIVKWFPPQRRGLAMGIRQTGIPIGGALASSTLPFFFYKYGLPSVI 174
Cdd:cd06173 287 ALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVF 366
|
170
....*....|....*..
gi 1098108237 175 LVQAIVTISGGLLFILF 191
Cdd:cd06173 367 LLAGALLLLAALLLLLL 383
|
|
| 2A0113 |
TIGR00892 |
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ... |
13-407 |
1.74e-05 |
|
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273325 [Multi-domain] Cd Length: 455 Bit Score: 46.66 E-value: 1.74e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 13 SYRWVILLIATISQTFATFVTYGIGPLASLWQQVHHLSQFQTGLLVS---AV--NIGPIFSMLpfgnlMDRYGERWIVGV 87
Cdd:TIGR00892 15 GWGWVVLGATFVSIGFSYAFPKAVTVFFKELQQIFQATYSETAWISSimlAVlyAGGPISSIL-----VNRFGCRPVVIA 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 88 GSVFLGASMLLAYPVTNYTYLVVILLFVGiWYGTA---QPggSKAIVKWFPPQRRGLAMGIRQTGIPIGGALASSTLPFF 164
Cdd:TIGR00892 90 GGLLASLGMILASFSSNVIELYLTAGFIT-GLGLAfnfQP--SLTMLGKYFYRRRPLANGLAMAGSPVFLSTLAPLNQYL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 165 FYKYGLPSVILvqaivtISGGLLF-------ILFYREERSTIQKIET------------ASFLTKLKQIRR-------ND 218
Cdd:TIGR00892 167 FESFGWRGSFL------ILGGLLLhccvcgaLMRPVGPSQRVSKSKSkeglppdgstkkLSKKSTAEKINRfldfslfTH 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 219 SLYPIFLIGITMMSLQMVLVSHLMSYLTNEVHTNLHHAGTLLSVVLLGGMIGRillawTSDNIFKGNRVIPLQITIGITI 298
Cdd:TIGR00892 241 RGFLVYLSGNVIMFLGFFAPIIFLVPYAKDKGVDEYEAAFLLSIIGFVDIFAR-----PSCGLIAGLKWIRPHVQYLFSF 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 299 LLL---LCMSFVMPYITFWLLVILCFFLGFfAIGWFS--LFIVLVSERSDPQFIGlTVSFALTLNQFAIVLAPALFGILV 373
Cdd:TIGR00892 316 ALLfngLTHLLCALAGDYTGLVIYCIFFGL-SFGSVGalLFEVLMDLVGAQRFSS-AVGLVTIVECCAVLIGPPLAGRLV 393
|
410 420 430
....*....|....*....|....*....|....
gi 1098108237 374 DYLHSYAAPFSILALLIALSGIWLTITEYRNKQL 407
Cdd:TIGR00892 394 DATKNYKYIFYASGSIVVSAGLFLAIGNYINYRL 427
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
16-205 |
2.09e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 46.43 E-value: 2.09e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 16 WVILLIATISQTFATFVTYGIGPLAslWQQVHHLSQFQTGLLVSAVNIGPIFSMLPFGNLMDRYGERWIVGVGSVFLGAS 95
Cdd:COG2211 230 FLLLLLAYLLFFLALALVAALLLYY--FKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALG 307
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 96 MLLAY--PVTNYTYLVVILLFVGIWYGTAQPGGSkAIV-------KWFPPQRR-GLAMGIRQTGIPIGGALASSTLPFFF 165
Cdd:COG2211 308 LLLLFflGPGNLWLLLVLAALAGIGLGAILVLPW-AMLadvvdydEWKTGRRReGLYFGIFTFAIKLGQALAGALAGLLL 386
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 1098108237 166 --------------YKYGLPSVILVQAIVTISGGLLFILFYREERSTIQKIETA 205
Cdd:COG2211 387 alfgyvagaaqspsALTGIRLLFFLLPAVLLLLAALLLLFYPLTRERHAEIRAE 440
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
71-396 |
4.96e-05 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 45.30 E-value: 4.96e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 71 PF-GNLMDRYGERWIVGVGSVFLGASMLLAYPVTNYTYLVVILLFVGIwYGTAQPGGSKAIVKWFPPQRRGLAMGIRQTG 149
Cdd:PRK09874 72 PFwGGLADRKGRKIMLLRSALGMGIVMVLMGLAQNIWQFLILRALLGL-LGGFVPNANALIATQVPRNKSGWALGTLSTG 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 150 IPIGGALASSTLPFFFYKYGLPSVILVQAIVTISGGLLFILFYREERSTIQKIETAS---FLTKLKQIRRNDSLYpifli 226
Cdd:PRK09874 151 GVSGALLGPLAGGLLADSYGLRPVFFITASVLFLCFLVTLFCIRENFQPVSKKEMLHmreVVTSLKNPKLVLSLF----- 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 227 gITMMSLQmVLVSHLMSYLTNEVHtnlHHAGTLLSVVLLGGMIGR---ILLAWTSDNIFK-GNRVIPLQITIG---ITIL 299
Cdd:PRK09874 226 -VTTLIIQ-VATGSIAPILTLYVR---ELAGNVSNIAFISGMIASvpgVAALLSAPRLGKlGDRIGPEKILITaliFSVL 300
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 300 LLLCMSFVMpyiTFWLLVILCFFLGFFAIGWFSLFIVLVSERSDPQFIGLTVSFALTLNQFAIVLAPaLFGILVDYLHSY 379
Cdd:PRK09874 301 LLIPMSFVQ---TPLQLGILRFLLGAADGALLPAVQTLLVYNSSNQIAGRIFSYNQSFRDIGNVTGP-LMGAAISANYGF 376
|
330
....*....|....*..
gi 1098108237 380 AAPFSILALLIALSGIW 396
Cdd:PRK09874 377 RAVFLVTAGVVLFNAVY 393
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
17-190 |
6.89e-05 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 44.51 E-value: 6.89e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 17 VILLIATISQTFATFVTYGIGPlaSLWQQVHHLSQFQTGLLVSAVNIGPIFSMLPFGNLMDRYGERWIVGVGSVFLGAS- 95
Cdd:cd17316 180 LLLILLWFFISFGYYGLTTFLP--TYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILa 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 96 ----MLLAYPVTNYTYLVVILLFVGIWYGTAQPggsKAIVKWFPPQRRGLAMGIRQTGIPIGGALASSTLPFFFYKYGLP 171
Cdd:cd17316 258 lplfYLLSGSPTLLLLLLFILSFFVGGVWGALY---AYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGT 334
|
170
....*....|....*....
gi 1098108237 172 SVILVQAIVTISGGLLFIL 190
Cdd:cd17316 335 GVPALILALLAIVALIVAL 353
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
47-153 |
7.17e-05 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 44.65 E-value: 7.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 47 HHLSQFQTGLLVSAVNIGPIFSMLPFGNLMDRYGER-------WIVGVGSVFLGASmllaypvTNYTYLVVILLFVGIWY 119
Cdd:cd17362 34 YNLSSLQSGLVVSGSLLGALLGSLVAGALIDRLGRRkelilaaLLYLVGSLVTGLA-------PSYPVLLVGRLIYGVGI 106
|
90 100 110
....*....|....*....|....*....|....
gi 1098108237 120 GTAQPGGSKAIVKWFPPQRRGLAMGIRQTGIPIG 153
Cdd:cd17362 107 GLAMHAAPVYIAETSPSHIRGLLVSLKELFIVLG 140
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
223-401 |
9.79e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 43.95 E-value: 9.79e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 223 IFLIGITMMSLQMVLVSHLMSYLTNEVHTNLHHAGTLLSVVLLGGMIGRILLAWTSDNIfkgNRVIPLQITIGITILLLL 302
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRF---GRRRVLLIGLLLFALGLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 303 CMSFVmpyITFWLLVILCFFLGFFAIGWFSLFIVLVSERSDPQFIGLTVSFALTLNQFAIVLAPALFGILVDYLhSYAAP 382
Cdd:pfam07690 78 LLLFA---SSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF-GWRAA 153
|
170
....*....|....*....
gi 1098108237 383 FSILALLIALSGIWLTITE 401
Cdd:pfam07690 154 FLILAILSLLAAVLLLLPR 172
|
|
| SP |
TIGR00879 |
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ... |
43-396 |
1.39e-04 |
|
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273317 [Multi-domain] Cd Length: 481 Bit Score: 43.87 E-value: 1.39e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 43 WQQVHHLSQFQTGLLVSAVNIGPIFSMLPFGNLMDRYGER---WIVGVGSVFLGASMLLAYPVTNYTYLVVILLFVGIWY 119
Cdd:TIGR00879 62 SANSDSYSSSLWGLVVSIFLVGGFIGALFAGWLSDRFGRKkslLIIALLFVIGAILMGLAAFALSVEMLIVGRVLLGIGV 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 120 GTAQPGGSKAIVKWFPPQRRGLAMGIRQTGIPIGGALA--SSTLPFFFYKYGLPSVILvqAIVTISGGLLFILF------ 191
Cdd:TIGR00879 142 GIASALVPMYLSEIAPKALRGALTSLYQLAITFGILVAygFGSGKVSLNNTLGWRIPL--GLQLIPAGLLFLGLfflpes 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 192 -------YREE-------RSTIQKIETASFLTKLKQIRRN--------------------DSLYPIFLIGITMMSLQMVL 237
Cdd:TIGR00879 220 prwlvgkGRVEearkslaRLRGTSGEDKELLDELELIDIKrsiekrsvqpswgslfsstrRIRRRLFLGVVLQWFQQFTG 299
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 238 VSHLMSYLT---NEVHTNLHHAGTLLSVVLLGGMIGRILLAWTSDNIfkGNRVIPLQITIGITILLLLCMSFVMPYIT-- 312
Cdd:TIGR00879 300 INAIMYYSPtifENAGVSTDHAFLVSIIVGAVNFAFTFVAIFLVDRF--GRRPLLLIGAAGMAICLFVLGILGASFVTgs 377
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 313 -----FWLLVILCFFLGFFAIGWFSLFIVLVSERSDPQFIGLTVSFALTLNQFAIVLAPALFGILVDYLHSYAApFSILA 387
Cdd:TIGR00879 378 skssgNVAIVFILLFIAFFAMGWGPVPWVIVSEIFPLSLRPKGISIAVAANWLANFIVGFLFPTMLESIGVGGV-FIFFG 456
|
....*....
gi 1098108237 388 LLIALSGIW 396
Cdd:TIGR00879 457 GLNVLGLIF 465
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
135-397 |
1.71e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 43.30 E-value: 1.71e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 135 PPQRRGLAMGIRQTGIPIGGALAS--STLPFFFYKYGLPSVILVQAIVTIsGGLLFILFYREERSTIQKIETASFLTKLK 212
Cdd:cd17370 118 PPSGRGKAFGLHRALDTLGAVLGPllAALLLYLLGGNYRTIFLLAAIPAL-LALLILLFVVKEYPRPPKLRKKSKKTSLK 196
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 213 QIRRndsLYPIFLIGITMMSLQMVLVShLMSYLTNEVHTNLHHAGTLLSVVLLGGMIGRILLAWTSDNIFKGNRVIplqI 292
Cdd:cd17370 197 KLPK---AFWLYLLAVALFALGNFSFA-FLILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLI---L 269
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 293 TIGITILLLLCMSFVmpyITFWLLVILCFFLGFFAIGWFSLFIVLVSERSDPQFIGLTVSFALTLNQFAIVLAPALFGIL 372
Cdd:cd17370 270 GYLSLALAYLGFALG---SSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYL 346
|
250 260
....*....|....*....|....*
gi 1098108237 373 VDYlHSYAAPFSILALLIALSGIWL 397
Cdd:cd17370 347 WDL-ISPSAAFLFSAVLALIALLLL 370
|
|
| MFS_GLUT12_Class3 |
cd17435 |
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
49-157 |
2.45e-04 |
|
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340993 [Multi-domain] Cd Length: 376 Bit Score: 42.86 E-value: 2.45e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 49 LSQFQTGLLVSAVNIGPIFSMLPFGNLMDRYGERWIVGVGSVFLGASMLLAYPVTNYTYLVVILLFVGIWYGTAQPGGSK 128
Cdd:cd17435 33 LSCHEQEMVVSSLLIGALLASLTGGVLIDRYGRRTAIILTSCLLVLGSLLLVCSVSYTVLIVGRIAIGVSISLSSIATCV 112
|
90 100
....*....|....*....|....*....
gi 1098108237 129 AIVKWFPPQRRGLAMGIRQTGIPIGGALA 157
Cdd:cd17435 113 YIAEIAPQHRRGLLVSLNELMIVIGILLA 141
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
36-396 |
2.72e-04 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 42.94 E-value: 2.72e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 36 IGPLASLWQqvhhLSQFQTGLLVSAVNIGPIFSMLPFGNLMDRYGERWIVGVGSVFLGASMLLAYPVTNYTYLVV--ILL 113
Cdd:cd17359 24 LPFLQTDFN----LTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIarIIG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 114 FVGIwygtaqpGGSKAIVKWF-----PPQRRGLAMGIRQTGIpIGGALASSTLPFFFYKYGLPSVILVQ------AIVTI 182
Cdd:cd17359 100 GLAV-------GGASALVPMYiaevaPAEIRGRLVSLNQLMI-VFGQLLAYIVNYLIANAGGADWLGAEgwrwmlGLEAI 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 183 SGGLLFILFYREErstiqkiETASFLTKLKQirrndslyPIFLIGITMMSLQMVLVSHLMSYLTNEVHTN--LHHAGTLL 260
Cdd:cd17359 172 PAILFLLGMLFIP-------ESPRWLVSKGK--------PILIIGIGLAIFQQFVGINVIFYYGPEIFQNagFSENAALL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 261 SVVLLGG--MIGRILLAWTSDNIFKgnrvIPLQI--TIGITILLLL---CMSFV-MPYITFWLLVIL-CFFLGFFAIGWF 331
Cdd:cd17359 237 QTIGIGVvnVIFTIIAILLVDKVGR----KPLLLigSIGMAISLLLigtAFYFApGSQASGIVALVLiLLFVAFFAMSWG 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1098108237 332 SLFIVLVSERSDPQFIGLTVSFALTLNQFAIVLAPALFGILVDYLHSyAAPFSILALLIALSGIW 396
Cdd:cd17359 313 PVTWVLLSEIFPNRIRGLAMGIAVFFLWIANFLVSLTFPILLAAFGL-AFTFLIFAVICVLAFLF 376
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
254-392 |
2.78e-04 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 42.95 E-value: 2.78e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 254 HHAGTLLSVVLLGGMIGRILLAWTSDNiFKGNRVIPLqiTIGITILLLLCMSFVMPYITFWLLVILCFFLGFFAigwFSL 333
Cdd:cd17339 231 ATAGWLLSLFQLVGIPASLLVPILATR-LKNQRPIVV--LLAVLFIIGVLGLLFAPTALALLWAVLLGLGGGAA---FSL 304
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 334 FIVLVSERS-DPQFIGLTVSFALTLNQFAIVLAPALFGILVDYLHSYAAPFSILALLIAL 392
Cdd:cd17339 305 ALTLISLRSsDPAEAAALSGMAQSVGYLLAALGPLLFGVLHDLTGSWTAPLVLLLALTVL 364
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
48-158 |
2.80e-04 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 43.03 E-value: 2.80e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 48 HLSQFQTGLLVSAVNIGPIFSMLPFGNLMDRYGeRWIVGVGSV--FLGASMLLAYpVTNYTYLVVILLFVGIWYGTAQPG 125
Cdd:PRK11551 46 GLDVAQMGWAFSAGILGLLPGALLGGRLADRIG-RKRILIVSValFGLFSLATAQ-AWDFPSLLVARLLTGVGLGGALPN 123
|
90 100 110
....*....|....*....|....*....|....*..
gi 1098108237 126 ----GSKAIvkwfPPQRRGLAMGIRQTGIPIGGALAS 158
Cdd:PRK11551 124 lialTSEAV----GPRLRGTAVSLMYCGVPFGGALAS 156
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
53-193 |
6.30e-04 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 41.84 E-value: 6.30e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 53 QTGLLVSAVNIGPIFSMLPFGNLMDRYGERWIVGVGSVFLGASMLLAYPVTNYTYLVVILLFVGIWYGTAQPGGSkAIVK 132
Cdd:cd06179 33 NSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQALIGIGAGTQGLGAA-VASE 111
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1098108237 133 WFPPQRRGLAMGIRQTGIPIGGALASSTLPFFFYKY--GLPSVILVQAIVTISGGLLFILFYR 193
Cdd:cd06179 112 LVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEANaaGWRWIFYINAIFNALALILLFFFYH 174
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
48-218 |
6.42e-04 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 41.85 E-value: 6.42e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 48 HLSQFQTGLLVSAVNIGPIFSMLPFGNLMDRYGERWIVGVGSVFLGASMLLAYPVTNYTYLVVILLFVGIWYGTAQPGGS 127
Cdd:cd17327 37 KLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTAAVKNFGGLIALRFFLGLFESGVFPGFI 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 128 KAIVKWFPPQRRGLAMGIRQTGIPIGGALASStLPFFFYKY----GLPS---VILVQAIVTISGGLLFILFYREErstiq 200
Cdd:cd17327 117 LYLGMWYKREEQAKRIAFFYAAAGLGSIFGGL-LAYGVFKIlgvgGLAGwrwLFIIEGLITIIIGLVIFFWLPDN----- 190
|
170 180
....*....|....*....|....
gi 1098108237 201 kIETASFLTK------LKQIRRND 218
Cdd:cd17327 191 -PSKAWFLTEeekelaVERLRANQ 213
|
|
| MFS_SLC49 |
cd17334 |
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The ... |
15-344 |
9.20e-04 |
|
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The Solute carrier 49 (SLC49) family is composed of four members: feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1); FLVCR2 (SLC49A2); major facilitator superfamily domain-containing protein 7 (MFSD7, SLC49A3); and disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. In addition, FLVCR2 also functions as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The function of MFSD7 is unknown. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. The SLC49 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340892 [Multi-domain] Cd Length: 407 Bit Score: 41.23 E-value: 9.20e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 15 RWVILLIATISQTFATFVTYGIGPLASLWQQVHHLSQFQTGLLVSAVNIGPIFSMLPFGNLMDRYGERW--IVGVGSVFL 92
Cdd:cd17334 2 RWVVLLLFSLLSFSNAMQWITFSPIADEARTFFDLSASQINWLSLVYPIVYVPGVFAFCWLLDKVGLRIgvLIGAALNAL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 93 GASMLLAYPVTNYTYLVVIL--LFVGIWYGTAQPGGSKAIVKWFPPQRRGLAMGIRQTGIPIGGALAsSTLPFFFYKYGL 170
Cdd:cd17334 82 GSVLKCIPLGQQPKFALLVLgqVLNALAQVLVLSLPPLIAAVWFPPKERTTATAIASLANFLGCAIG-FLLPPVVVPPPK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 171 PSVILVQAIVTISGG-----LLFILFYREER--------STIQKIETASFLTKLKQIRRNDSLYPIFLIGIT--MMSLQM 235
Cdd:cd17334 161 GTKKEFGAVFYGEFGfacllLALVLALFPPKpkyppsaaSARQQNSEHVILELQKSISELLRNEPFVLLAVAfsIMMGVF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 236 VLVSHLMSYLTNEVHTNLHHAGTLLSVVLLGGMIGRILLAWTSDNIfKGNRVIPLQI----TIGITILLLLCMSFVMPYI 311
Cdd:cd17334 241 AGFSSVLAQILLPFGVSQTSAGWLGFFGIVAGMVGGLLLGLFVDRT-RMFKLIGLIIlalgTVVCTFFMLLVDRYGLPYV 319
|
330 340 350
....*....|....*....|....*....|...
gi 1098108237 312 TfWLLVILCFFLGFFAIGWFSLFIVLVSERSDP 344
Cdd:cd17334 320 T-LAFYLLCGLLGFFQNSMVPIMFELAVELTYP 351
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
48-190 |
9.92e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 41.02 E-value: 9.92e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 48 HLSQFQTGLLVSAVNIGPIFSMLPF-GNLMDRYGERWIVGVGSVFLGASMLLAYPVTNYTYLVVILLFVGIWYGTAQPGG 126
Cdd:cd17330 206 GFSPSQIGLLLALVGIAGILAQLLLiPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPAL 285
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1098108237 127 SKAIVKWFPPQRRGLAMGIRQTGIPIGGALASSTLPFFFYKYGLPSVILVQAIVTISGGLLFIL 190
Cdd:cd17330 286 SALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLLSL 349
|
|
| MFS_MCT7 |
cd17422 |
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; ... |
245-399 |
1.59e-03 |
|
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 7 (MCT7) is also called Solute carrier family 16 member 6 (SLC16A6). Zebrafish MCT7 is required for hepatocyte secretion of ketone bodies during fasting; it has been shown to be a selective transporter of the major ketone body beta-hydroxybutyrate, whose abundance is increased during fasting. MCT7 is expressed in the brain, pancreas, muscle, and prostate. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340980 [Multi-domain] Cd Length: 363 Bit Score: 40.50 E-value: 1.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 245 LTNEVHTNLHHAGTLLSVVLLGGMIGRILLAWTSdnifkgNRVIPLQITIGITILLLLCMS-FVMPYIT-FWLLVILCFF 322
Cdd:cd17422 209 LSLSLGIDQDWAAYMLSAMAIAELFGRISAGWVL------NKCPIRKIYIELICVILLCVVlLLFPFAYgFWSLLVCSIF 282
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1098108237 323 LGFFAIGWFSLFIVLVSERS--DPQFIGLTVSFALTLNQFAIVLAPALFGILVDYLHSYAAPFSILALLIALSGIWLTI 399
Cdd:cd17422 283 YGFMFGTVAGTHIPLLAEDDvvGIEKMSSALGVYVFIQSIAGLAGPPLGGVLVDWTQNYGSAFYSCAAGMALGAVFLAL 361
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
46-326 |
1.74e-03 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 40.28 E-value: 1.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 46 VHHLSQFQTGLLVSAVNIGPIFSMLPFGNLMDRYGERW-----IVGVGSVFLGASMLLAY--PVTNYTYLVVILLFVGIW 118
Cdd:cd17332 29 VLGLSAAAAGTIFLVARIIDAINDPLMGYLIDRTRSRWgrfrpWLLWGAIPLALLFVLLFttPDGSGTGKLIYALITYIL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 119 YGTAQPGGSKAIVKWFP-----PQRRGLAMGIRQTGIPIGGALASSTLPFFF----YKYGLPSVILVQAIVTISGGLLFI 189
Cdd:cd17332 109 LDLLYTLVNIPYTALIPeltddPEERTSLTSWRMFFATIGGLLVTVLPPPLVayfgGGNASRGYFLTALIIGIIGIILLL 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 190 LFY----REERSTIQKIETASFLTKLKQIRRNDSLYPIFLIGITMMSLQMVLVSHLMSYLTnevHTNLHHAGTLLSVVLL 265
Cdd:cd17332 189 ICFfgtrERVVPPEEEKSKLPLLKSLKALLKNRPFLILLLAYLLYFLAFNIVNTVLVYYFK---YVLGGRAELVLLLLLI 265
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1098108237 266 GGMIGrILLAWTSDNIFKGNRVIPLQITIGITILLLLcMSFVMPYITFWLLVILCFFLGFF 326
Cdd:cd17332 266 LSGAL-LALLPWPPLKKRFGKKKAFFIGLLLAILGLL-LLFFLPPGNLVLILVLAVLAGIG 324
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
15-164 |
1.76e-03 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 40.20 E-value: 1.76e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 15 RWVILLIATISQtFATFVTYGIGP--LASLWQQVHHLSQFQTGLLVSAVNIGPIFSMLPFGNLMDRYGERWIVGVGSVFL 92
Cdd:cd17369 226 HWRALLLAIGLR-LAENVLFYLFTtfALSYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLA 304
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1098108237 93 GASMLLAYPV---TNYTYLVVILLFVG--IWYGTAQPGGSkAIVKWFPPQRRGLAMGIrqtGIPIGGALASSTLPFF 164
Cdd:cd17369 305 ALFAFPFFWLldtGSTWLIVLAAVVVLgvLHGMMYGPQAA-FLAELFPTRVRYTGASL---GYQLGAILGGGFAPLI 377
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
2-189 |
3.62e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 39.08 E-value: 3.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 2 QKQKTRNDSTSSYRWVILLIATISQTFATFVTYGIGPLASLWQQVHHLSQFQTGLLVSAVNIGPIFSMLPFGNLMDRYGE 81
Cdd:cd17478 180 AAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGR 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 82 RWIVgVGSVFLGASMLLAYPVTNYTYLVVILLFVGIWYGTAQPgGSKAIVKWFPPQRRGLAMGIrQTGIPIG-GALASST 160
Cdd:cd17478 260 RRVI-IASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFP-VTVVLAQELLPGNVGLASGL-MMGLSFGlGGIGAPV 336
|
170 180
....*....|....*....|....*....
gi 1098108237 161 LPFFFYKYGLPSVILVQAIVTISGGLLFI 189
Cdd:cd17478 337 LGALADAFGLESVLLILALLPLLGALLAF 365
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
48-393 |
3.97e-03 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 39.09 E-value: 3.97e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 48 HLSQFQTGLLVSAVNIGPIFSMLPFGNLMDRYGERWIVGVGSVFLGASMLLAYPVTNYTYLVVILLFVGIWYGTAQPGGS 127
Cdd:cd17315 30 GLSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGLGVGLASVLVP 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 128 KAIVKWFPPQRRGLAMGIRQTGIpIGGALASSTLPFFFYKYGLPSVILVQAIVTISGGLLFILFYREERStiqkietasf 207
Cdd:cd17315 110 LYISEIAPAKIRGALGTLNQLMI-TFGILLAYLLGLALSLSPPGWWRLMFALAAVPALLQLLLMFFLPES---------- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 208 ltklkqirrndslyPIFLIGITMMSLQMVLVSHLMSYLTNEVHTNLH--HAGTLLSVVL-LGGMIGRILLAWTSDniFKG 284
Cdd:cd17315 179 --------------RALLVGVGLQLLQQLTGINAVMYYAPTIFKSAGggTASILASIIVgVVNLLATLVAIRLVD--KVG 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 285 NRVIPLQITIGITILLLLC-----MSFVMPYITFWLLVILCFFLGFFAIGWFSLFIVLVSERSDPQFIGLTVSFALTLNQ 359
Cdd:cd17315 243 RRPLLLIGFAGMAASLLLLaiaflLPALAKAAGWLALLGILLYIAAFAMGAGPVPWLLLSEIFPLRIRGKGMAIATLVNW 322
|
330 340 350
....*....|....*....|....*....|....
gi 1098108237 360 FAIVLAPALFGILVDYLHsYAAPFSILALLIALS 393
Cdd:cd17315 323 IFNFIVGLTFLIMVSTIG-LAGVFIFFAAVCLLA 355
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
15-189 |
5.48e-03 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 38.56 E-value: 5.48e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 15 RWVILLIATISQTFATFVTygIGPLASLWQQVHHLSQFQTGLLVSAVNIGPIFSMLPFGNLMDRY-GERWIVGVGSVFLG 93
Cdd:cd06174 204 GLWLLLLAIFLVNLAYYSF--STLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLiGRKPLLLIGLLLMA 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 94 ASMLLAYPVTNYTYLVVILLFVGIWYGTAQPGGSKAIVKWFPPQRRGLAMGIRQTGIPIGGALASSTLPFFFY-KYGLPS 172
Cdd:cd06174 282 LGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAaTFGLTG 361
|
170
....*....|....*..
gi 1098108237 173 VILVQAIVTISGGLLFI 189
Cdd:cd06174 362 AFLVLAVLLLLAAILLL 378
|
|
| MFS_MCT12 |
cd17424 |
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; ... |
254-397 |
5.85e-03 |
|
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 12 (MCT12) is also called Solute carrier family 16 member 12 (SLC16A12). It is a creatine transporter encoded by the cataract and glucosuria associated gene SLC16A12. A heterozygous mutation of the gene causes a syndrome with juvenile cataracts, microcornea, and glucosuria. MCT12 may function in a basolateral exit pathway for creatine in the proximal tubule. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340982 [Multi-domain] Cd Length: 363 Bit Score: 38.64 E-value: 5.85e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 254 HHAGTLLSVVLLGGMIGRILLAWTSDNIF-KGNRVIPLQITIGITILLLLCMSFVMpyiTFWLLVILCFFLGFFAIGWFS 332
Cdd:cd17424 218 QQAAFLMSILGVIDIIGNITFGWLTDRRClKKYRYFCYLFAVGMDGLCCLFLPILK---TFPLLVPFSFTFGYFDGAYVA 294
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1098108237 333 LFIVLVSERSDPQFIGLTVSFALTLNQFAIVLAPALFGILVDYLHSYAAPFSILALLIALSGIWL 397
Cdd:cd17424 295 LIPVVTSDVVGTSSLSSALGVVYFLHAVPYLVSPPIAGWLVDTTGTYTAAFLLSGFSMIFSSLLL 359
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
48-395 |
6.48e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 38.36 E-value: 6.48e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 48 HLSQFQTGLLVSAVNIGPIFSMLPFGNLMDRYGERWI-VGVGSVFLGASMLLAYPVTNYTYLVVILLFVGIwygtaqpGG 126
Cdd:cd17490 27 GASLSMIGIILGAYGISQMLLRIPLGILSDRIGKRKLfIIIGLLFTVLASLIMILFPSPWGLLIARFLSGI-------AA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 127 SKAIV------KWFPPQRRGLAMGIRQTGIPIGGALASSTLPFFFYKYGLPSVILVQAIVTISgGLLFILFYREERSTiq 200
Cdd:cd17490 100 ATWVSftvlyaSYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVL-GFILSLFIKEERRE-- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 201 KIETASFLTKLKQIRRNDSLYPIFLIGITMMSLQMVLVshlmSYLTNEVHTNLHHAGTLLSVVLLGGMIGRILLAWTSDN 280
Cdd:cd17490 177 KKPVLTELKELLSVLKDKKLLFFSLLAILQQMITFSTT----FGFTPLIAKQLGASSFQLGLLSIIYLLPNALASLLSGT 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 281 IFKgnRVIPLQITIGITILLLLCMSFVMPYI-TFWLLVILCFFLGFFAIGWFSLFIVLVSERSDPQFIGLTVSFALTLNQ 359
Cdd:cd17490 253 LFY--KKLGERNTIIIGFLLLGAYCFLIPFApNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAIYA 330
|
330 340 350
....*....|....*....|....*....|....*.
gi 1098108237 360 FAIVLAPALFGILVDYLhSYAAPFSILALLIALSGI 395
Cdd:cd17490 331 LGMFLGPVLVGIISEAF-GLQTGFFVIGVIALLAAI 365
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
68-391 |
7.11e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 38.31 E-value: 7.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 68 SMLPFGNLMDRYGERWIVGVGSVFLGASMLLAYPVTNYTYLVVILLFVGIWYGTAQPGGSKAIVKWFPPQRRGLAMGIRQ 147
Cdd:cd17321 47 LLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWG 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 148 TGIPIG---GALASSTLPFFFykyGLPSVILVQAIVTISGGLLFILFyreerstiqkieTASFLTklkqirrndslypIF 224
Cdd:cd17321 127 AVVGIGaalGPLLGGLLLELF---GWRWIFLINVPIGLVALLLARTF------------SGAVLA-------------AF 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 225 LIGITMMSLQMVLVSHLMSYLtnevHTNLHHAGTLLSVVLLGGMIGRILLAWTSDnifkgnRVIPLQITIG---ITILLL 301
Cdd:cd17321 179 LLGAALGGLLFLLPLYLQGVL----GYSPLQAGLALLPLALAMLVAAPLAGRLAD------RFGPRLVLVAgllLTAVGL 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 302 LCMSFVMPYITFWLLVILCFFLGF-FAIGWFSLFIVLVSErSDPQFIGLTVSFALTLNQFAIVLAPALFGILVDYLHSYA 380
Cdd:cd17321 249 LLLALLGADSSVWLLLPGLVLLGLgLGLFATPLTNAALSS-VPKEKAGAASGILNTARQLGGALGVALLGALLTAGLSAN 327
|
330
....*....|.
gi 1098108237 381 APFSILALLIA 391
Cdd:cd17321 328 LGDSGVAALLS 338
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
49-164 |
7.41e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 38.33 E-value: 7.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 49 LSQFQTGLLVSAVNIGPIFSMLPFGNLMDRYGERWIVGVGSVFLGAS-MLLAYPVTNYTYLVVILLFVGIWYGTAQPGGS 127
Cdd:cd17504 214 LGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGlLLLALLHSSLWALVVALLLIGIGLGLAFASLP 293
|
90 100 110
....*....|....*....|....*....|....*..
gi 1098108237 128 KAIVKWFPPQRRGLAMGIRQTGIPIGGALASSTLPFF 164
Cdd:cd17504 294 NIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAI 330
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
211-396 |
9.27e-03 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 38.37 E-value: 9.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 211 LKQIRRNDslyPIFL--IGITM-MSLQMVLVSHLMSYLTNEVH-TNLHHAGTLLSVVLLGGMIGRILLA-WTSDNIFKGn 285
Cdd:PRK08633 225 LKLLRSDR---VLWLaiIGLSYfWFISQLAQANFPAYAKEVLGlDNTFQVQYLLAASAIGIGIGSLLAGrLSGRHIELG- 300
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098108237 286 rVIPLQItIGITIllllcMSFVMPY-ITFWLLVILCFFLGFFAigwfSLFIV----LVSERSDPQFIGLTVSFALTLNQF 360
Cdd:PRK08633 301 -LVPLGA-LGLAL-----SLFLLPTaPSLASVLVLFFLFGFSA----GLFIVplnaLIQFRAPEKELGKVLAANNFLQNV 369
|
170 180 190
....*....|....*....|....*....|....*.
gi 1098108237 361 AIVLAPALFGILVDYLHSYAAPFSILALLIALSGIW 396
Cdd:PRK08633 370 GMLLFLALTTLFSGLGLSPAGLFYLIALVTLIGTLY 405
|
|
| |
