RecName: Full=F-box only protein 32
List of domain hits
Name | Accession | Description | Interval | E-value | ||
F-box_FBXO32 | cd22103 | F-box domain found in F-box only protein 32 (FBXO32) and similar proteins; FBXO32, also called ... |
223-270 | 1.62e-27 | ||
F-box domain found in F-box only protein 32 (FBXO32) and similar proteins; FBXO32, also called FBX32, atrogin-1, or muscle atrophy F-box protein (MAFbx), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during skeletal muscle atrophy. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. : Pssm-ID: 438875 Cd Length: 48 Bit Score: 102.24 E-value: 1.62e-27
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Name | Accession | Description | Interval | E-value | ||
F-box_FBXO32 | cd22103 | F-box domain found in F-box only protein 32 (FBXO32) and similar proteins; FBXO32, also called ... |
223-270 | 1.62e-27 | ||
F-box domain found in F-box only protein 32 (FBXO32) and similar proteins; FBXO32, also called FBX32, atrogin-1, or muscle atrophy F-box protein (MAFbx), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during skeletal muscle atrophy. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438875 Cd Length: 48 Bit Score: 102.24 E-value: 1.62e-27
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Name | Accession | Description | Interval | E-value | ||
F-box_FBXO32 | cd22103 | F-box domain found in F-box only protein 32 (FBXO32) and similar proteins; FBXO32, also called ... |
223-270 | 1.62e-27 | ||
F-box domain found in F-box only protein 32 (FBXO32) and similar proteins; FBXO32, also called FBX32, atrogin-1, or muscle atrophy F-box protein (MAFbx), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during skeletal muscle atrophy. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438875 Cd Length: 48 Bit Score: 102.24 E-value: 1.62e-27
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F-box_FBXO25 | cd22099 | F-box domain found in F-box only protein 25 (FBXO25) and similar proteins; FBXO25, also called ... |
224-268 | 9.06e-16 | ||
F-box domain found in F-box only protein 25 (FBXO25) and similar proteins; FBXO25, also called FBX25, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It functions as a negative regulator of MAPK signaling though the reduction of ERK1/2 activation. It controls Tbx5 and Nkx2-5 transcriptional activity to regulate cardiomyocyte development. FBXO25 also plays a crucial role in tumorigenesis. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438871 Cd Length: 45 Bit Score: 70.27 E-value: 9.06e-16
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F-box_FBXO7 | cd22087 | F-box domain found in F-box only protein 7 (FBXO7) and similar proteins; FBXO7, also called ... |
228-270 | 2.41e-05 | ||
F-box domain found in F-box only protein 7 (FBXO7) and similar proteins; FBXO7, also called FBX7, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It recognizes BIRC2 and DLGAP5. FBXO7 plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PRKN to dysfunctional depolarized mitochondria. It promotes MFN1 ubiquitination. FBXO7 acts as a cell cycle regulator by enhancing cyclin D/cyclin-dependent kinase 6 (Cdk6) complex formation and stabilizing levels of p27, a cyclin-dependent kinase inhibitor. Mutations in the FBXO7 (PARK15) gene have been implicated in a juvenile form of parkinsonism called parkinsonian pyramidal syndrome (PPS), characterized by Parkinsonian symptoms and pyramidal tract signs. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438859 Cd Length: 45 Bit Score: 41.13 E-value: 2.41e-05
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F-box_FBXO4 | cd22085 | F-box domain found in F-box only protein 4 (FBXO4) and similar proteins; FBXO4, also called ... |
224-270 | 3.19e-04 | ||
F-box domain found in F-box only protein 4 (FBXO4) and similar proteins; FBXO4, also called FBX4, is a specific substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that catalyzes the ubiquitination and subsequent degradation of cyclin D1 and Trx1. It recognizes TERF1 and promotes its ubiquitination together with UBE2D1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438857 Cd Length: 50 Bit Score: 38.16 E-value: 3.19e-04
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F-box_FBXW8 | cd22134 | F-box domain found in F-box/WD repeat-containing protein 8 (FBXW8) and similar proteins; FBXW8, ... |
227-270 | 3.84e-03 | ||
F-box domain found in F-box/WD repeat-containing protein 8 (FBXW8) and similar proteins; FBXW8, also called F-box and WD-40 domain-containing protein 8, or F-box only protein 29 (FBXO29), is the substrate-recognition component of a Cul7-RING ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as GORASP1, IRS1, MAP4K1/HPK1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438906 Cd Length: 48 Bit Score: 35.04 E-value: 3.84e-03
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F-box_FBXO3 | cd22084 | F-box domain found in F-box only protein 3 (FBXO3) and similar proteins; FBXO3, also called ... |
227-274 | 6.85e-03 | ||
F-box domain found in F-box only protein 3 (FBXO3) and similar proteins; FBXO3, also called FBX3, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. It also promotes ubiquitylation and transcriptional activity of AIRE (autoimmune regulator). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438856 Cd Length: 49 Bit Score: 34.16 E-value: 6.85e-03
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Blast search parameters | ||||
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