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Conserved domains on  [gi|1102546649|gb|APC57481|]
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Topo1 (plasmid) [Enterococcus faecium]

Protein Classification

type IA DNA topoisomerase( domain architecture ID 13449637)

type IA DNA topoisomerase resolves single strand DNA recombination and replication intermediates

EC:  5.6.2.1
Gene Ontology:  GO:0006265|GO:0003917|GO:0003677
PubMed:  19208647

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK07726 super family cl35606
DNA topoisomerase 3;
1-362 7.25e-98

DNA topoisomerase 3;


The actual alignment was detected with superfamily member PRK07726:

Pssm-ID: 236078 [Multi-domain]  Cd Length: 658  Bit Score: 305.55  E-value: 7.25e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649   1 MQGLYE-AKLLSYPRTDTPFITENEFAYLKA------NFGKYSGFLGLDLEmvqTEPRKRYVDGSKVQEHHAIIPTKQVP 73
Cdd:PRK07726  305 AQSLYEtHKLITYPRTDSRYLPEDMVATLPEvlnaisKVDPYLLLAPPVLD---PSIRSRAWNDKKVTAHHAIIPTEQPP 381

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649  74 tesALAKMDDLQRKIYALVVKTTVAMFLPDYLYEETKIQTKVADLLFQSIGKTPKQEGWKILFKQQTKEEKEDvQTLPLV 153
Cdd:PRK07726  382 ---NLSKLSEDERKVYDLIARRYLAQFLPPAEYDKTTIELEIAGGTFIAKGKQVVEAGWKALLGKKEEDEEKE-QPLPVL 457

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649 154 IIGERAEV-GVKSVEKETQPPKAFTEGTLLTAMKTANKTVDDEEAIKILQEVEGIGTEATRASIIEALKQKEYIQVIKNK 232
Cdd:PRK07726  458 AKGDELKVeKGEVKEGQTQPPKRFTEGTLLSAMENIARFVQDKELKKTLKETDGLGTEATRAGIIEKLFKRGYLEKKGKY 537

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649 233 LVVTEKGKLLCQAVESQhlLTSAEMTAKWETYLKKIGKREGNQENFITNIKKFIVHLLEavpndieklnfsDYQEQKEKE 312
Cdd:PRK07726  538 IHATDKGKQLIDALPEE--LTSPDMTAKWEQALDQISEGQLSYQDFMQPLKQWLKQLVE------------QAKQSSEKY 603

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1102546649 313 AEKSIVG-KCPKCGNNIVLKKS----FYGCSNYPECKFTLAEHFRKKKLTKTNVK 362
Cdd:PRK07726  604 KFDNLTGpKCPDCGKPMLKVKGkngkMLVCQDRECGKRKNVSKKTNARCPNCKKK 658
Toprim_Crpt pfam13342
C-terminal repeat of topoisomerase;
343-397 1.34e-07

C-terminal repeat of topoisomerase;


:

Pssm-ID: 463851 [Multi-domain]  Cd Length: 60  Bit Score: 47.86  E-value: 1.34e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1102546649 343 CKFTLAEHFRKKKLTKTNVKELLEGKET-LVKGIKNKEKKPYNAVVKIGEKGYIDF 397
Cdd:pfam13342   2 CGFSIGKTIAGKKLSEEQVKELLTKGKTgLIKGFKSKKGKKFDAYLVLDDDEKVEF 57
 
Name Accession Description Interval E-value
PRK07726 PRK07726
DNA topoisomerase 3;
1-362 7.25e-98

DNA topoisomerase 3;


Pssm-ID: 236078 [Multi-domain]  Cd Length: 658  Bit Score: 305.55  E-value: 7.25e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649   1 MQGLYE-AKLLSYPRTDTPFITENEFAYLKA------NFGKYSGFLGLDLEmvqTEPRKRYVDGSKVQEHHAIIPTKQVP 73
Cdd:PRK07726  305 AQSLYEtHKLITYPRTDSRYLPEDMVATLPEvlnaisKVDPYLLLAPPVLD---PSIRSRAWNDKKVTAHHAIIPTEQPP 381

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649  74 tesALAKMDDLQRKIYALVVKTTVAMFLPDYLYEETKIQTKVADLLFQSIGKTPKQEGWKILFKQQTKEEKEDvQTLPLV 153
Cdd:PRK07726  382 ---NLSKLSEDERKVYDLIARRYLAQFLPPAEYDKTTIELEIAGGTFIAKGKQVVEAGWKALLGKKEEDEEKE-QPLPVL 457

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649 154 IIGERAEV-GVKSVEKETQPPKAFTEGTLLTAMKTANKTVDDEEAIKILQEVEGIGTEATRASIIEALKQKEYIQVIKNK 232
Cdd:PRK07726  458 AKGDELKVeKGEVKEGQTQPPKRFTEGTLLSAMENIARFVQDKELKKTLKETDGLGTEATRAGIIEKLFKRGYLEKKGKY 537

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649 233 LVVTEKGKLLCQAVESQhlLTSAEMTAKWETYLKKIGKREGNQENFITNIKKFIVHLLEavpndieklnfsDYQEQKEKE 312
Cdd:PRK07726  538 IHATDKGKQLIDALPEE--LTSPDMTAKWEQALDQISEGQLSYQDFMQPLKQWLKQLVE------------QAKQSSEKY 603

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1102546649 313 AEKSIVG-KCPKCGNNIVLKKS----FYGCSNYPECKFTLAEHFRKKKLTKTNVK 362
Cdd:PRK07726  604 KFDNLTGpKCPDCGKPMLKVKGkngkMLVCQDRECGKRKNVSKKTNARCPNCKKK 658
TOP1Ac cd00186
DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA ...
 2-290 8.65e-78

DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA and then rejoin the broken phosphodiester backbone. Proposed catalytic mechanism of single stranded DNA cleavage is by phosphoryl transfer through a tyrosine nucleophile using acid/base catalysis. Tyr is activated by a nearby group (not yet identified) acting as a general base for nucleophilic attack on the 5' phosphate of the scissile bond. Arg and Lys stabilize the pentavalent transition state. Glu then acts as a proton donor for the leaving 3'-oxygen, upon cleavage of the scissile strand.


Pssm-ID: 238110 [Multi-domain]  Cd Length: 381  Bit Score: 245.21  E-value: 8.65e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649   2 QGLYEAKLLSYPRTDTPFITENEFAYLKANFGKYSGFLGLDLEMVQTePRKRYVDGSKVQEHHAIIPTKQVPTESALAKM 81
Cdd:cd00186   112 QKLYEAGLITYPRTDSTRLSEEAILEAREYIQAIYGKEYLYPAPLLG-RRNPKRGKKEQGAHEAIRPTKVAPTPELEANL 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649  82 DDLQRKIYALVVKTTVAMFLPDYLYEETKIQTKVADLLFQSIGKTPKQEGWKILFKQQTKEEKEDvqTLPLVIIGERAEV 161
Cdd:cd00186   191 SEDEFKLYELIWRRFLASQMADAKYEETTVTLEIGGEKFKASGKVLLEDGWLEVYPEEKDDEEEE--PPPLKEGDELKLE 268

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649 162 GVKSVEKETQPPKAFTEGTLLTAMKTanktvddeeaikilqevEGIGTEATRASIIEALKQKEYIQVIKNKLVVTEKGKL 241
Cdd:cd00186   269 EVELEEKETQPPPRYTEASLIKLMEK-----------------RGIGRPSTYASIIETLLDRGYVEKEKKKLIPTELGFA 331

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1102546649 242 LCQAVESQ-HLLTSAEMTAKWETYLKKIGKREGNQENFITNIKKFIVHLL 290
Cdd:cd00186   332 VIELLEKHfPELVDPEFTAKLEEKLDEIAEGKKDYQEVLEEFYEEFKKIV 381
topB TIGR01056
DNA topoisomerase III, bacteria and conjugative plasmid; This model describes topoisomerase ...
 2-344 9.34e-73

DNA topoisomerase III, bacteria and conjugative plasmid; This model describes topoisomerase III from bacteria and its equivalents encoded on plasmids. The gene is designated topB if found in the bacterial chromosome, traE on conjugative plasmid RP4, etc. These enzymes are involved in the control of DNA topology. DNA topoisomerase III belongs to the type I topoisomerases, which are ATP-independent. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273419 [Multi-domain]  Cd Length: 660  Bit Score: 239.75  E-value: 9.34e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649   2 QGLYEA-KLLSYPRTDTPFITENEFAYLKANFGKYSG--FLGLDLEMVQTEPRKRYVDGSKVQEHHAIIPTKQvptESAL 78
Cdd:TIGR01056 309 QKLYEThKLITYPRTDSRYLPEDEKEMLLEVLDALKVitPALLPIKKRDELTNNRLWNDKKIEDHHAIIPTGN---DFNL 385

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649  79 AKMDDLQRKIYALVVKTTVAMFLPDYLYEETKIQTKVADLLFQSIGKTPKQEGWKILFKQQTKEEKEDVQTLPLVIIGER 158
Cdd:TIGR01056 386 SDLSEEERNVYKLIAQNYLMQFMPKEEYETTTIEIAIGKLMFEAKGKILQDNGWKALLGKQEEDEETEDTTLPAFQKGDE 465

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649 159 AEV-GVKSVEKETQPPKAFTEGTLLTAMKTANKTVDDEEAIKILQEVEGIGTEATRASIIEALKQKEYIQVIKNKLVVTE 237
Cdd:TIGR01056 466 LDVeTLELLEKQTKPPARYTEGTLLSAMTNPAAFVQDKGLKKTLKETKGLGTEATRADIIENLFKRGFIQKKKNKIYITK 545

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649 238 KGKLLCQAVEsqHLLTSAEMTAKWETYLKKIGKREGNQENFITNIKKFIVHLLeavpNDIEKLNFSDYQEQKEKEAEKSI 317
Cdd:TIGR01056 546 NGKLLCLLLP--ELLTKPDLTAQWEQYLNGISAGEKDDDDFINTINEMIKQTI----NEEKKNPETIQKVAKEPVSCGGI 619

                         330       340
                  ....*....|....*....|....*..
gi 1102546649 318 vGKCPKCGNNIvlkksFYGCSNYPECK 344
Cdd:TIGR01056 620 -AKCPAKDNGR-----LIDCKKFPECT 640
TOP1Ac smart00437
Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, ...
 1-242 4.60e-72

Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, Eukaryotic DNA topoisomeraes III, reverse gyrase alpha subunit


Pssm-ID: 214663 [Multi-domain]  Cd Length: 259  Bit Score: 226.36  E-value: 4.60e-72
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649    1 MQGLYEAKLLSYPRTDTPFITENEFAYLKANFGKYSGFLGLDLEMVQTEPRKRYVDGSKVQEHHAIIPTKQVPTESALAK 80
Cdd:smart00437  37 AQKLYEKGLITYPRTDSTRLSEEAVLEARNYIQKLYGKEYLDLAVVLLKPRKPRKGKKAQGAHEAIRPTKPIFTPELEKE 116

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649   81 MDDLQRKIYALVVKTTVAMFLPDYLYEETKIQTKVADLLFQSIGKTPKQEGWKILFKqqtKEEKEDVQTLPLVIIGERAE 160
Cdd:smart00437 117 LSEDEFKLYELIWRRFLASQMPDAKYEETKVTIKIGGEKFKAKGKTLLFDGWLKVYP---EEKKEEEIELPTLKKGDELK 193

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649  161 VG-VKSVEKETQPPKAFTEGTLLTAMKTanktvddeeaikilqevEGIGTEATRASIIEALKQKEYIQVIKNKLVVTEKG 239
Cdd:smart00437 194 VEeVEVEEKETKPPARYTEASLIKLMEK-----------------RGIGRPSTYASIIETLLDRGYVTKKKKKLIPTELG 256


                   ...
gi 1102546649  240 KLL 242
Cdd:smart00437 257 IAV 259
TopA COG0550
DNA topoisomerase IA [Replication, recombination and repair];
1-291 1.78e-65

DNA topoisomerase IA [Replication, recombination and repair];


Pssm-ID: 440316 [Multi-domain]  Cd Length: 541  Bit Score: 217.66  E-value: 1.78e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649   1 MQGLYEAKLLSYPRTDTPFITENEFA----YLKANFGKysGFLGldlemvqtePRKRYVDGSK-VQE-HHAIIPTKQVPT 74
Cdd:COG0550   273 AQRLYEVGLITYMRTDSVRLSEDAVAaareYIEALYGK--EYLP---------EKPRVYKTSKnAQEaHEAIRPTGVTRT 341

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649  75 esaLAKMDDLQRKIYALVVKTTVAMFLPDYLYEETKIQTKVADLLFQSIGKTPKQEGWKILFKQQTKEEKEDV-QTLPLV 153
Cdd:COG0550   342 ---PESLSGDEFKLYDLIWKRFLASQMPPAEYETTTVTIEVGGEEFRASGKVIKFPGFLKVYGEGKDDEEEEEeKRLPPL 418

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649 154 IIGERAEV-GVKSVEKETQPPKAFTEGTLLTAMktanktvddEEAikilqeveGIGTEATRASIIEALKQKEYIQVIKNK 232
Cdd:COG0550   419 KEGEKLKLkKIEPEQHFTKPPPRYTEASLVKAM---------EEL--------GIGRPSTYASIIETLQDRGYVEREGKR 481

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1102546649 233 LVVTEKGKLLCQAVEsQHL--LTSAEMTAKWETYLKKIGKREGNQENFITNIKKFIVHLLE 291
Cdd:COG0550   482 LVPTELGFIVIDLLE-EHFpdLVDYEFTAKMEEKLDEIAEGKLDWKDVLEEFYKPFKELVE 541
Topoisom_bac pfam01131
DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes ...
 2-279 1.94e-63

DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes preferentially relax negatively supercoiled DNA, from a 5' phospho- tyrosine linkage in the enzyme-DNA covalent intermediate and has high affinity for single stranded DNA.


Pssm-ID: 426069 [Multi-domain]  Cd Length: 410  Bit Score: 209.02  E-value: 1.94e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649   2 QGLYE-AKLLSYPRTDTPFITE-NEFAYLKANFGKYSGFLGLDLEMVQTEPR-KRYVDGSKVQEHHAIIPTKQVPTESAL 78
Cdd:pfam01131 151 QKLYEkHGLITYPRTDSTYLSDdATLKAILEYLTKNYGKYLPYAPRLLKKTKgKLTVGNAKVTAHEAIRPTGDIPVLPEL 230

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649  79 akmDDLQRKIYALVVKTTVAMFLPDYLYEETKIQTKVADLLFQSIGKTPKQEGWKILFKqqtKEEKEDVQTLPLVIIGER 158
Cdd:pfam01131 231 ---SDDERKLYELIVRRFLASQMPPAVYETTTVVLEVGGEEFRASGKVILEDGWLKVYP---YEKKEDEEELPELKEGEE 304

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649 159 AEV-GVKSVEKETQPPKAFTEGTLLTAMKTAnktvddeeaikilqeveGIGTEATRASIIEALKQKEYIQVIKNKLVVTE 237
Cdd:pfam01131 305 LKVtQVEVEEKKTKPPPRYTEASLIKAMEKA-----------------GIGTPATRATIIETLLERGYVERKKKSLVPTE 367

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1102546649 238 KGKLLCQAVESQHLLTSAEMTAKWETYLKKIGKREGNQENFI 279
Cdd:pfam01131 368 LGKALVEALEKFPDLVDPELTAELEEKLDEIAEGKLDWKDVL 409
Toprim_Crpt pfam13342
C-terminal repeat of topoisomerase;
343-397 1.34e-07

C-terminal repeat of topoisomerase;


Pssm-ID: 463851 [Multi-domain]  Cd Length: 60  Bit Score: 47.86  E-value: 1.34e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1102546649 343 CKFTLAEHFRKKKLTKTNVKELLEGKET-LVKGIKNKEKKPYNAVVKIGEKGYIDF 397
Cdd:pfam13342   2 CGFSIGKTIAGKKLSEEQVKELLTKGKTgLIKGFKSKKGKKFDAYLVLDDDEKVEF 57
 
Name Accession Description Interval E-value
PRK07726 PRK07726
DNA topoisomerase 3;
1-362 7.25e-98

DNA topoisomerase 3;


Pssm-ID: 236078 [Multi-domain]  Cd Length: 658  Bit Score: 305.55  E-value: 7.25e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649   1 MQGLYE-AKLLSYPRTDTPFITENEFAYLKA------NFGKYSGFLGLDLEmvqTEPRKRYVDGSKVQEHHAIIPTKQVP 73
Cdd:PRK07726  305 AQSLYEtHKLITYPRTDSRYLPEDMVATLPEvlnaisKVDPYLLLAPPVLD---PSIRSRAWNDKKVTAHHAIIPTEQPP 381

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649  74 tesALAKMDDLQRKIYALVVKTTVAMFLPDYLYEETKIQTKVADLLFQSIGKTPKQEGWKILFKQQTKEEKEDvQTLPLV 153
Cdd:PRK07726  382 ---NLSKLSEDERKVYDLIARRYLAQFLPPAEYDKTTIELEIAGGTFIAKGKQVVEAGWKALLGKKEEDEEKE-QPLPVL 457

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649 154 IIGERAEV-GVKSVEKETQPPKAFTEGTLLTAMKTANKTVDDEEAIKILQEVEGIGTEATRASIIEALKQKEYIQVIKNK 232
Cdd:PRK07726  458 AKGDELKVeKGEVKEGQTQPPKRFTEGTLLSAMENIARFVQDKELKKTLKETDGLGTEATRAGIIEKLFKRGYLEKKGKY 537

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649 233 LVVTEKGKLLCQAVESQhlLTSAEMTAKWETYLKKIGKREGNQENFITNIKKFIVHLLEavpndieklnfsDYQEQKEKE 312
Cdd:PRK07726  538 IHATDKGKQLIDALPEE--LTSPDMTAKWEQALDQISEGQLSYQDFMQPLKQWLKQLVE------------QAKQSSEKY 603

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1102546649 313 AEKSIVG-KCPKCGNNIVLKKS----FYGCSNYPECKFTLAEHFRKKKLTKTNVK 362
Cdd:PRK07726  604 KFDNLTGpKCPDCGKPMLKVKGkngkMLVCQDRECGKRKNVSKKTNARCPNCKKK 658
TOP1Ac cd00186
DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA ...
 2-290 8.65e-78

DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA and then rejoin the broken phosphodiester backbone. Proposed catalytic mechanism of single stranded DNA cleavage is by phosphoryl transfer through a tyrosine nucleophile using acid/base catalysis. Tyr is activated by a nearby group (not yet identified) acting as a general base for nucleophilic attack on the 5' phosphate of the scissile bond. Arg and Lys stabilize the pentavalent transition state. Glu then acts as a proton donor for the leaving 3'-oxygen, upon cleavage of the scissile strand.


Pssm-ID: 238110 [Multi-domain]  Cd Length: 381  Bit Score: 245.21  E-value: 8.65e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649   2 QGLYEAKLLSYPRTDTPFITENEFAYLKANFGKYSGFLGLDLEMVQTePRKRYVDGSKVQEHHAIIPTKQVPTESALAKM 81
Cdd:cd00186   112 QKLYEAGLITYPRTDSTRLSEEAILEAREYIQAIYGKEYLYPAPLLG-RRNPKRGKKEQGAHEAIRPTKVAPTPELEANL 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649  82 DDLQRKIYALVVKTTVAMFLPDYLYEETKIQTKVADLLFQSIGKTPKQEGWKILFKQQTKEEKEDvqTLPLVIIGERAEV 161
Cdd:cd00186   191 SEDEFKLYELIWRRFLASQMADAKYEETTVTLEIGGEKFKASGKVLLEDGWLEVYPEEKDDEEEE--PPPLKEGDELKLE 268

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649 162 GVKSVEKETQPPKAFTEGTLLTAMKTanktvddeeaikilqevEGIGTEATRASIIEALKQKEYIQVIKNKLVVTEKGKL 241
Cdd:cd00186   269 EVELEEKETQPPPRYTEASLIKLMEK-----------------RGIGRPSTYASIIETLLDRGYVEKEKKKLIPTELGFA 331

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1102546649 242 LCQAVESQ-HLLTSAEMTAKWETYLKKIGKREGNQENFITNIKKFIVHLL 290
Cdd:cd00186   332 VIELLEKHfPELVDPEFTAKLEEKLDEIAEGKKDYQEVLEEFYEEFKKIV 381
topB TIGR01056
DNA topoisomerase III, bacteria and conjugative plasmid; This model describes topoisomerase ...
 2-344 9.34e-73

DNA topoisomerase III, bacteria and conjugative plasmid; This model describes topoisomerase III from bacteria and its equivalents encoded on plasmids. The gene is designated topB if found in the bacterial chromosome, traE on conjugative plasmid RP4, etc. These enzymes are involved in the control of DNA topology. DNA topoisomerase III belongs to the type I topoisomerases, which are ATP-independent. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273419 [Multi-domain]  Cd Length: 660  Bit Score: 239.75  E-value: 9.34e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649   2 QGLYEA-KLLSYPRTDTPFITENEFAYLKANFGKYSG--FLGLDLEMVQTEPRKRYVDGSKVQEHHAIIPTKQvptESAL 78
Cdd:TIGR01056 309 QKLYEThKLITYPRTDSRYLPEDEKEMLLEVLDALKVitPALLPIKKRDELTNNRLWNDKKIEDHHAIIPTGN---DFNL 385

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649  79 AKMDDLQRKIYALVVKTTVAMFLPDYLYEETKIQTKVADLLFQSIGKTPKQEGWKILFKQQTKEEKEDVQTLPLVIIGER 158
Cdd:TIGR01056 386 SDLSEEERNVYKLIAQNYLMQFMPKEEYETTTIEIAIGKLMFEAKGKILQDNGWKALLGKQEEDEETEDTTLPAFQKGDE 465

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649 159 AEV-GVKSVEKETQPPKAFTEGTLLTAMKTANKTVDDEEAIKILQEVEGIGTEATRASIIEALKQKEYIQVIKNKLVVTE 237
Cdd:TIGR01056 466 LDVeTLELLEKQTKPPARYTEGTLLSAMTNPAAFVQDKGLKKTLKETKGLGTEATRADIIENLFKRGFIQKKKNKIYITK 545

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649 238 KGKLLCQAVEsqHLLTSAEMTAKWETYLKKIGKREGNQENFITNIKKFIVHLLeavpNDIEKLNFSDYQEQKEKEAEKSI 317
Cdd:TIGR01056 546 NGKLLCLLLP--ELLTKPDLTAQWEQYLNGISAGEKDDDDFINTINEMIKQTI----NEEKKNPETIQKVAKEPVSCGGI 619

                         330       340
                  ....*....|....*....|....*..
gi 1102546649 318 vGKCPKCGNNIvlkksFYGCSNYPECK 344
Cdd:TIGR01056 620 -AKCPAKDNGR-----LIDCKKFPECT 640
TOP1Ac smart00437
Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, ...
 1-242 4.60e-72

Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, Eukaryotic DNA topoisomeraes III, reverse gyrase alpha subunit


Pssm-ID: 214663 [Multi-domain]  Cd Length: 259  Bit Score: 226.36  E-value: 4.60e-72
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649    1 MQGLYEAKLLSYPRTDTPFITENEFAYLKANFGKYSGFLGLDLEMVQTEPRKRYVDGSKVQEHHAIIPTKQVPTESALAK 80
Cdd:smart00437  37 AQKLYEKGLITYPRTDSTRLSEEAVLEARNYIQKLYGKEYLDLAVVLLKPRKPRKGKKAQGAHEAIRPTKPIFTPELEKE 116

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649   81 MDDLQRKIYALVVKTTVAMFLPDYLYEETKIQTKVADLLFQSIGKTPKQEGWKILFKqqtKEEKEDVQTLPLVIIGERAE 160
Cdd:smart00437 117 LSEDEFKLYELIWRRFLASQMPDAKYEETKVTIKIGGEKFKAKGKTLLFDGWLKVYP---EEKKEEEIELPTLKKGDELK 193

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649  161 VG-VKSVEKETQPPKAFTEGTLLTAMKTanktvddeeaikilqevEGIGTEATRASIIEALKQKEYIQVIKNKLVVTEKG 239
Cdd:smart00437 194 VEeVEVEEKETKPPARYTEASLIKLMEK-----------------RGIGRPSTYASIIETLLDRGYVTKKKKKLIPTELG 256


                   ...
gi 1102546649  240 KLL 242
Cdd:smart00437 257 IAV 259
TopA COG0550
DNA topoisomerase IA [Replication, recombination and repair];
1-291 1.78e-65

DNA topoisomerase IA [Replication, recombination and repair];


Pssm-ID: 440316 [Multi-domain]  Cd Length: 541  Bit Score: 217.66  E-value: 1.78e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649   1 MQGLYEAKLLSYPRTDTPFITENEFA----YLKANFGKysGFLGldlemvqtePRKRYVDGSK-VQE-HHAIIPTKQVPT 74
Cdd:COG0550   273 AQRLYEVGLITYMRTDSVRLSEDAVAaareYIEALYGK--EYLP---------EKPRVYKTSKnAQEaHEAIRPTGVTRT 341

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649  75 esaLAKMDDLQRKIYALVVKTTVAMFLPDYLYEETKIQTKVADLLFQSIGKTPKQEGWKILFKQQTKEEKEDV-QTLPLV 153
Cdd:COG0550   342 ---PESLSGDEFKLYDLIWKRFLASQMPPAEYETTTVTIEVGGEEFRASGKVIKFPGFLKVYGEGKDDEEEEEeKRLPPL 418

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649 154 IIGERAEV-GVKSVEKETQPPKAFTEGTLLTAMktanktvddEEAikilqeveGIGTEATRASIIEALKQKEYIQVIKNK 232
Cdd:COG0550   419 KEGEKLKLkKIEPEQHFTKPPPRYTEASLVKAM---------EEL--------GIGRPSTYASIIETLQDRGYVEREGKR 481

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1102546649 233 LVVTEKGKLLCQAVEsQHL--LTSAEMTAKWETYLKKIGKREGNQENFITNIKKFIVHLLE 291
Cdd:COG0550   482 LVPTELGFIVIDLLE-EHFpdLVDYEFTAKMEEKLDEIAEGKLDWKDVLEEFYKPFKELVE 541
Topoisom_bac pfam01131
DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes ...
 2-279 1.94e-63

DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes preferentially relax negatively supercoiled DNA, from a 5' phospho- tyrosine linkage in the enzyme-DNA covalent intermediate and has high affinity for single stranded DNA.


Pssm-ID: 426069 [Multi-domain]  Cd Length: 410  Bit Score: 209.02  E-value: 1.94e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649   2 QGLYE-AKLLSYPRTDTPFITE-NEFAYLKANFGKYSGFLGLDLEMVQTEPR-KRYVDGSKVQEHHAIIPTKQVPTESAL 78
Cdd:pfam01131 151 QKLYEkHGLITYPRTDSTYLSDdATLKAILEYLTKNYGKYLPYAPRLLKKTKgKLTVGNAKVTAHEAIRPTGDIPVLPEL 230

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649  79 akmDDLQRKIYALVVKTTVAMFLPDYLYEETKIQTKVADLLFQSIGKTPKQEGWKILFKqqtKEEKEDVQTLPLVIIGER 158
Cdd:pfam01131 231 ---SDDERKLYELIVRRFLASQMPPAVYETTTVVLEVGGEEFRASGKVILEDGWLKVYP---YEKKEDEEELPELKEGEE 304

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649 159 AEV-GVKSVEKETQPPKAFTEGTLLTAMKTAnktvddeeaikilqeveGIGTEATRASIIEALKQKEYIQVIKNKLVVTE 237
Cdd:pfam01131 305 LKVtQVEVEEKKTKPPPRYTEASLIKAMEKA-----------------GIGTPATRATIIETLLERGYVERKKKSLVPTE 367

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1102546649 238 KGKLLCQAVESQHLLTSAEMTAKWETYLKKIGKREGNQENFI 279
Cdd:pfam01131 368 LGKALVEALEKFPDLVDPELTAELEEKLDEIAEGKLDWKDVL 409
PRK08173 PRK08173
DNA topoisomerase III; Validated
 2-391 7.62e-45

DNA topoisomerase III; Validated


Pssm-ID: 236172 [Multi-domain]  Cd Length: 862  Bit Score: 166.00  E-value: 7.62e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649   2 QGLYEA-KLLSYPRTDTPFITENEFAYLKANFGK------YSGFLGLDLEMVQTEPRKRYVDGSKVQEHHAIIPTKQVPt 74
Cdd:PRK08173  316 QALYEKhKVLTYPRTDSRALPEDYLGTVKQTLEMlkesnnYLPHAKQILDKGWVKPNKRIFDNSKISDHFAIIPTLQAP- 394

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649  75 esalAKMDDLQRKIYALVVKTTVAMFLPDYLYEETKIQTKVADLLFQSIGKTPKQEGWKILFkqqTKEEKEDVQTLPLVI 154
Cdd:PRK08173  395 ----KSLSEPEQKLYDLVVKRFLAVFFPAAEFLVTTRITEVAGHHFKTEGKVLVNPGWLAVY---GKEAQGADANLVPVQ 467

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649 155 IGERAEV-GVKSVEKETQPPKAFTEGTLLTAMKTANKTVDDEEAIKILQEvEGIGTEATRASIIEALKQKEYIQVIKNKL 233
Cdd:PRK08173  468 KGEKVKTdKIEAVALTTKPPARYNEATLLSAMEGAGKLVEDDELREAMAE-KGLGTPATRAAIIEGLLGEKYLVREGREL 546

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649 234 VVTEKG----KLL-CQAVESqhlLTSAEMTAKWETYLKKIGKREGNQENFITNIKKFIVHLLEAVPNDIEKLNFSDYQEQ 308
Cdd:PRK08173  547 IPTAKAfqlmTLLrGLGVEE---LTSPELTGEWEYKLSQIERGKLSRDAFMQEIAQMTQQIVKRAKEYDSDTIPGDYATL 623

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649 309 KEkeaeksivgKCPKCGNniVLKKSF--YGCSnypECKFTLAEHFRKKKLTKTNVKELLEGKET-LVKGIKNKEKKPYNA 385
Cdd:PRK08173  624 QT---------PCPNCGG--VVKENYrrFACT---KCDFSISKIPGGRQFEIAEVEELLRKKEIgPLSGFRSKMGRPFSA 689


                  ....*.
gi 1102546649 386 VVKIGE 391
Cdd:PRK08173  690 ILKLSD 695
PRK14724 PRK14724
DNA topoisomerase III; Provisional
 2-389 2.60e-40

DNA topoisomerase III; Provisional


Pssm-ID: 237803 [Multi-domain]  Cd Length: 987  Bit Score: 152.80  E-value: 2.60e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649   2 QGLYEA-KLLSYPRTDTPFITENEFAYLKANFGKYSG--------FLGLDLEMVQTEPRKRYVDGSKVQEHHAIIPTKQV 72
Cdd:PRK14724  324 QSLYERhKALTYPRTDSRALPEDYLPVAKQTFEMLATsgmrhlapFAQQALDGNYVRPSKRIFDNSKVSDHFAIIPTTQA 403

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649  73 PTesalaKMDDLQRKIYALVVKTTVAMFLPDYLYEETKIQTKVADLLFQSIGKTPKQEGWKILFKQQTKEEKEDVQT--- 149
Cdd:PRK14724  404 PS-----GLSEAEQKLYDLVVRRFMAVFFPSAEYQVTTRISQVVGHSFKTEGKVLVKPGWLAIYGKEAANEVEDAKDgdk 478

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649 150 -LPLVIIGERAEVGVKSVEK---ETQPPKAFTEGTLLTAMKTANKTVDDEEAIKILQEvEGIGTEATRASIIEALKQKEY 225
Cdd:PRK14724  479 gQPLVPVKPGEMVRTEFAEAkglKTKPPARYSEATLLGAMESAGKQIDDDELREAMQE-KGLGTPATRAAIIEGLLTEKY 557

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649 226 IQVIKNKLVVTEKG---KLLCQAVESQHlLTSAEMTAKWETYLKKIGKREGNQENFITNIKKFIVHLLeavpndieklnf 302
Cdd:PRK14724  558 MLREGRELIPTAKAfqlMTLLRGLGVEE-LSRAELTGEWEYKLAQMEKGQLSREAFMQQIAAMTEKLV------------ 624

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649 303 sdyqeQKEKEAEKSIV--------GKCPKCGNniVLKKSF--YGCSNY----PECKFTLAEHFRKKKLTKTNVKELLEGK 368
Cdd:PRK14724  625 -----KKAKEYDRDTIpgdyatlsTPCPNCGG--VVKENYrrYACTGAngagEGCGFSFTKSPAGRTFETAEAEQLLRDR 697

                         410       420
                  ....*....|....*....|..
gi 1102546649 369 ET-LVKGIKNKEKKPYNAVVKI 389
Cdd:PRK14724  698 RIgPLEGFRSKAGWPFTAEVVI 719
PRK07219 PRK07219
DNA topoisomerase I; Validated
 2-347 3.55e-38

DNA topoisomerase I; Validated


Pssm-ID: 235971 [Multi-domain]  Cd Length: 822  Bit Score: 146.30  E-value: 3.55e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649   2 QGLYEAKLLSYPRTDTPFITEN-EFAYLKANFGKYSGFlGLDLEMVQTEPRKRYVDGSK-VQEHHAIIPTKQVPTEsala 79
Cdd:PRK07219  309 EKLYTAGYISYPRTDNTVYPDDlDPKELLKKLSKKKEY-GPYAESILEQENIKPTEGKKeTTDHPPIHPVDVPKRE---- 383

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649  80 KMDDLQRKIYALVVKTTVAMFLPDYLYEETKIQTKVADLLFQSIGKTPKQEGWKILFKQQTKEEKEdvqtLPLVIIGEra 159
Cdd:PRK07219  384 ELSDDEWKVYELIVRRFLATLADPAEWEYLKVELDVNGEIFKASGSRLVEEGWHEVYPYEKFDEKE----LPDLEEGE-- 457

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649 160 EVGVKSV---EKETQPPKAFTEGTLLTAMktanktvddeeaikilqEVEGIGTEATRASIIEALKQKEYiqVIKNK-LVV 235
Cdd:PRK07219  458 KLKVNKIeieAKETQPPKRYTQSSLIKEM-----------------EKRGLGTKATRHDIIEKLYKRGY--VIEGDpPRP 518

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649 236 TEKGKLLCQAVE-SQHLLTSAEMTAKWETYLKKIGKREgnqenfitniKKFivhllEAVPNDIEKLNFSDYQEQKEKEAE 314
Cdd:PRK07219  519 TDLGIAVIEALEkYAPEIVSEEMTAQLEADMQAIEDGK----------KKK-----EDVTEESREMLKEILSELKEKRKE 583

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1102546649 315 ------KSI---------VGKCPKCGNNIVLKKS-----FYGCSNYPECKFTL 347
Cdd:PRK07219  584 igdhlaGSLkaenrslktIGKCPECGGDLIIIRTdkgsrFVGCSGYPDCRNTF 636
topA_arch TIGR01057
DNA topoisomerase I, archaeal; This model describes topoisomerase I from archaea. These ...
 2-343 3.10e-32

DNA topoisomerase I, archaeal; This model describes topoisomerase I from archaea. These enzymes are involved in the control of DNA topology. DNA topoisomerase I belongs to the type I topoisomerases, which are ATP-independent. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273420 [Multi-domain]  Cd Length: 618  Bit Score: 128.41  E-value: 3.10e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649   2 QGLYEAKLLSYPRTDTPFITEN-EFAYLKANFGKYSGFlGLDLEMVQTEPRKRYVDGSKVQEHH-AIIPTKQVPTEsala 79
Cdd:TIGR01057 300 QELYEEALISYPRTSSQKLPPSiNYRAILDNLAKGPLY-REAAERLLETGVLKPVEGKKEDPAHpAIHPTGEIPSQ---- 374

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649  80 KMDDLQRKIYALVVKTTVAMFLPDYLYEETKIQTKVADLLFQSIGKTPKQEGWKILFKQQTKEEKEdvqtLPLVIIGERA 159
Cdd:TIGR01057 375 ELSKDEKKVYDLIVRRFLAAFSEEAIREKSKVLLRIGQEKFRLSGLRVVKLGWLEYYHYSKFEEKE----LPPLDRGDKI 450

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649 160 EV-GVKSVEKETQPPKAFTEGTLLTAMktanktvddeeaikilqEVEGIGTEATRASIIEALKQKEYIQViKNKLVVTEK 238
Cdd:TIGR01057 451 KVvRVDVRVKETQPPARYDKASLIREM-----------------ESRGLGTKATRARIIETLYKRGYIEG-KKSIKVTPL 512

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649 239 GKLLCQAVESQ-HLLTSAEMTAKWETYLKKIGKREGNQENFITNIKKFIVHLLEavpndieklNFSDYQEQKEKEAEKS- 316
Cdd:TIGR01057 513 GEAVIETLQRYcPEIISEELTRRFESKLEDIMSGRITKDEVIDEAKKRLRKILE---------EFKKRLDDIGIELGKSl 583

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 1102546649 317 ----IVGKCPKCGNNIVLKKS----FYGCSNYPEC 343
Cdd:TIGR01057 584 gsveVVGKCPKCGGKLVSKYAkkgrFVGCSNYPEC 618
PRK07220 PRK07220
DNA topoisomerase I; Validated
 4-347 4.11e-32

DNA topoisomerase I; Validated


Pssm-ID: 180892 [Multi-domain]  Cd Length: 740  Bit Score: 128.34  E-value: 4.11e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649   4 LYEAKLLSYPRTDTPFITE-----NEFAYLKAN-FGKYSGFLGLDLEMVQTEPRKRYVDgskvqeHHAIIPTkqvptesA 77
Cdd:PRK07220  304 LYTNGYISYPRTDNTVYPEsldlrEQIEIFAEGpFGEYAQKLLEKGELVPTRGKKETTD------HPPIYPA-------S 370

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649  78 LAKMDDL---QRKIYALVVKTTVAMFLPDYLYEETKIQTKVADLLFQSIGKTPKQEGWKILFKQQTKEEKEdvqtLPLVI 154
Cdd:PRK07220  371 LAKKSELkedEWKVYELVVRRFFATFAGPAEWETMKLRFDIGGEEFRANGSRLTEPGWRWYYPYNAPEDRL----LPELS 446

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649 155 IGERAEVGVKSV-EKETQPPKAFTEGTLltamktanktvddeeaIKILQEVeGIGTEATRASIIEALKQKEYIQviKNKL 233
Cdd:PRK07220  447 EGEELKVKKKEMlDKETQPPGRYGQGRL----------------IKLMEDL-GLGTKATRHEIISKLYSRAYIH--GNPI 507

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649 234 VVTEKGKLLCQAVES-QHLLTSAEMTAKWETYLKKIGKREGNQENFITNIKKfivhLLEAVPNDIEKlNFSDYQEQ-KEK 311
Cdd:PRK07220  508 QPTNTAFAVVDALEKyAPTITKPDMTSRLEEDMDKIAEGKIKEDAVLEESRE----MLEQVFDELDK-NREKIRESlREG 582

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 1102546649 312 EAEKSIVGKCPKCGNNIVLKKS-----FYGCSNYPECKFTL 347
Cdd:PRK07220  583 LREDKIIGKCPLCGSDLMVRRSkrgsrFIGCEGYPECTFSL 623
PRK05776 PRK05776
DNA topoisomerase I; Provisional
 2-358 9.81e-28

DNA topoisomerase I; Provisional


Pssm-ID: 235602 [Multi-domain]  Cd Length: 670  Bit Score: 115.47  E-value: 9.81e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649   2 QGLYEAKLLSYPRTDTPFI--TENEFAYLK--ANFGKYSGFLGLDLEMvqTEPRKRYVDGSKVQEHH-AIIPTKQVPTes 76
Cdd:PRK05776  303 EDLYLDGLISYPRTNSQKLppTLNIRNILKglSRSPQYRPLVNLLLKE--TKGVLKPVQGPKDDPAHpAIYPTGEPPK-- 378

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649  77 alaKMDDLQRKIYALVVKTTVAMFLPDYLYEETKIQTKVAD--LLFQSIGKTPKQEGWKILFKQQTKEEKEdvqtLPLVI 154
Cdd:PRK05776  379 ---NLSKDEFKLYDLIVRRFLASFAAPAVLSNTIVTLRVPGfpLVFSASGQRIEERGWLKYYPFHKFDEEE----LPLLK 451

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649 155 IGERAEV-GVKSVEKETQPPKAFTEGTLLTAMktanktvddeeaikilqEVEGIGTEATRASIIEALKQKEYIQVIKNKL 233
Cdd:PRK05776  452 KGERVKIvDVKVRKSYTKPPSRYSKASLLKWM-----------------ESVGIGTEATRARIIETLFKRGYLTSNGKYI 514

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649 234 VVTEKGKLLCQAVESQHL-LTSAEMTAKWETYLKKI--GKRegNQENFITNIKKFIVHLLEAVPNDIEKLNfsdyQEQKE 310
Cdd:PRK05776  515 EVTPLGFGVAEVLEKYFPdIVSVELTRDFEEKLEMIrtGKA--TREEVIEEAKETLNKLLEEFKKNKDEIG----EELAK 588

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1102546649 311 KEAEKSIVGKCPKCG-----NNIV-----LKKSFYGCSNYPECKFTLAEHFRKKKLTK 358
Cdd:PRK05776  589 ALGLIKPVGKCKICGreaykDGLCkyhyeAKKRLVKAYEEWKERTGYDHKEYLEKISK 646
PRK14973 PRK14973
DNA topoisomerase I; Provisional
 4-345 3.38e-27

DNA topoisomerase I; Provisional


Pssm-ID: 184936 [Multi-domain]  Cd Length: 936  Bit Score: 114.17  E-value: 3.38e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649   4 LYEAKLLSYPRTDT----PFITENEF--AYLKANFGKYSGFLGLDLEMVQTEPRKRYVDgskvqeHHAIIPTKqVPTESA 77
Cdd:PRK14973  303 LYMNGYISYPRTDNtiypKSLDLNGVlaTLAKGAFSKDVAWVKDNRRPVPTRGKKSSTD------HPPIHPTG-VATREE 375

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649  78 LAkmdDLQRKIYALVVKTTVAMFLPDYLYEETKIQTKVADLLFQSIGKTPKQEGWKILFKQQtkEEKEDVqtLPLVIIGE 157
Cdd:PRK14973  376 LG---DDRWKLYELVVRRFLATLSPDAEWATMKVNFDAGGEPYTATGGRLLEAGWRTVYPYS--EAKENI--LPAFALGE 448

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649 158 RAEV-GVKSVEKETQPPKAFTEGTLLTAMktanktvddEEAikilqeveGIGTEATRASIIEALKQKEYIQviKNKLVVT 236
Cdd:PRK14973  449 KLPIlAVNLEEKETQPPARYSQSRLIQRM---------EEL--------GLGTKSTRHEVIGKLVSRKYIE--GNPLRPT 509

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649 237 EKGKLLCQAVEsQH--LLTSAEMTAKWETYLKKIGKREGNQENFITNIKKfivhLLEAVPNDIEKLNFSDYQEQKEKEAE 314
Cdd:PRK14973  510 LVGRAVTESLE-EHagTITEPDMTQTLEEHMQQIKERKRTRDDVVTESRK----MLHRAFDELEANEAVIGRDIMERTAE 584

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 1102546649 315 KSIVGKCPKCGNNIVLKK----SFYGCSNYPECKF 345
Cdd:PRK14973  585 ELTIGPCPVCGKDLRIKHigssQFIGCSGYPDCTF 619
PRK07561 PRK07561
DNA topoisomerase I subunit omega; Validated
 2-346 7.30e-27

DNA topoisomerase I subunit omega; Validated


Pssm-ID: 236048 [Multi-domain]  Cd Length: 859  Bit Score: 112.96  E-value: 7.30e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649   2 QGLYEAKLLSYPRTDTPFITENEFA----YLKANFGKysgflgldlEMVQTEPRkRYvdGSKV---QE-HHAIIPTKQVP 73
Cdd:PRK07561  296 QRLYEAGYITYMRTDSTNLSQEAINaargYIGDNYGK---------KYLPEKPR-QY--SSKAknaQEaHEAIRPSDVFR 363

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649  74 TESALAKMDDLQRKIYALVVKTTVAMFLPDYLYEETKIQTKVADLLFQSIGKTPKQEGW-KILFKQQTKEEKEDVQTLPL 152
Cdd:PRK07561  364 TPDQLKGLEGDAQRLYELIWKRFVASQMAPARYDSTTVTIAAGDAELRATGRVLRFDGFlKVYVEGRDDALDDEDRRLPA 443

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649 153 VIIGERAEVG-VKSVEKETQPPKAFTEGTLltamktanktvddeeaIKILQEvEGIGTEATRASIIEALKQKEYIQVIKN 231
Cdd:PRK07561  444 LKVGDALTLEkLDPTQHFTKPPARYSEASL----------------VKELEK-LGIGRPSTYASIISTIQDRGYVRLENR 506

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649 232 KLVVTEKG----KLLcqaVESQHLLTSAEMTAKWETYLKKI--GKREGNQ--ENFitnIKKFIVHLLEAVpndieklnfS 303
Cdd:PRK07561  507 RFYPEKMGrivtDRL---EEFFPRLVDYDFTARMEEELDDIanGEADWKPvlDDF---YKDFSQQLEKAE---------E 571

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1102546649 304 DYQEQKEKEAEKSIVG-KCPKCGNNIVLK----KSFYGCSNY---PECKFT 346
Cdd:PRK07561  572 LREEGGMRPNQMVITDrDCPTCGRGMGIRtgktGVFLGCSGYalkERCKTT 622
PRK06599 PRK06599
DNA topoisomerase I; Validated
 2-346 4.26e-23

DNA topoisomerase I; Validated


Pssm-ID: 235840 [Multi-domain]  Cd Length: 675  Bit Score: 101.47  E-value: 4.26e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649   2 QGLYEA--------KLLSYPRTDTPFITeNEF-----AYLKANFGKysgflgldlEMVQTEPRKRYVDGSKVQE-HHAII 67
Cdd:PRK06599  286 QKLYEGidlgegtvGLITYMRTDSVRLS-NEAldearKYITKKYGK---------EYLPAKPRVYKKKSKNAQEaHEAIR 355

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649  68 PTKQVPT-ESALAKMDDLQRKIYALVVKTTVAMFLPDYLYEETK--IQTKVADLLFQSIGKTPKQEGWKILFKQQTKEEK 144
Cdd:PRK06599  356 PTSINRTpESLKPYLTPDQFKLYELIWKRTVASQMAPAILDQTSvdIASENGKYVFRATGSVILFPGFLKVYGESKDDEE 435

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649 145 ED-VQTLPLVIIGEraEVGVKSVEKE---TQPPKAFTEGTLLTAMktanktvddeeaikilqEVEGIGTEATRASIIEAL 220
Cdd:PRK06599  436 EDdEKLLPPLKEGE--KLKLDELLPEqhfTEPPPRYSEASLVKKL-----------------EEYGIGRPSTYASIISTL 496

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649 221 KQKEYIQVIKNKLVVTEKGKLLCQavesqhLLTS-------AEMTAKWETYLKKI--GKREgnqenFITNIKKFIVHLLE 291
Cdd:PRK06599  497 QDREYVELEKKRFIPTDLGRIVND------FLVEhfpkyvdYDFTAGLEDELDEIaeGKKD-----WKPVLREFWEPFIS 565

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649 292 AVpNDIEKlnfsdyQEQKEKEAEKSIVGKCPKC-GNNIVLK----KSFYGCSNYPECKFT 346
Cdd:PRK06599  566 NL-EKVEE------DVRTEKVTQEETDETCPKCgGGPLVLKlgknGKFLGCSGYPECKYT 618
PRK06319 PRK06319
DNA topoisomerase I/SWI domain fusion protein; Validated
 2-349 1.30e-16

DNA topoisomerase I/SWI domain fusion protein; Validated


Pssm-ID: 235778 [Multi-domain]  Cd Length: 860  Bit Score: 81.79  E-value: 1.30e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649   2 QGLYEA---------KLLSYPRTDT----PFITENEFAYLKANFGKysgflgldlEMVQTEPrKRYVDGSKVQE-HHAII 67
Cdd:PRK06319  296 QTLYEGvdldsegatGLITYMRTDSvrtdPEALKQVRKYIEGTFGK---------EFLPSSP-NVYTTKKMAQDaHEAIR 365

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649  68 PTK-QVPTESALAKMDDLQRKIYALVVKTTVAMFLPDYLYEETKIQ-TKVADLLFQSIGKTPKQEGWKILFKQQTKEEKE 145
Cdd:PRK06319  366 PTDiTLTPEKLRSKLTEDQYKLYSLIWKRFVASQMIPAIYDTLAIRiTTNKGIDLRATGSLLKFKGFLAVYEEKRDDEGD 445

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649 146 DVQTLPLVIIGERAEVGVKSVEKE---TQPPKAFTEGTLLTAMktanktvddeeaikilqEVEGIGTEATRASIIEALKQ 222
Cdd:PRK06319  446 EEENIHLPKLHEQDVLTKEELSAEqafTKPLPRFTEASLVKEL-----------------EKSGIGRPSTYATIMNKIQS 508

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649 223 KEYIQVIKNKLVVTEKGKLLCQAVESQH-LLTSAEMTAKWETYLKKIGKregNQENFITNIKKFIVHLLEAVpndiekln 301
Cdd:PRK06319  509 REYTLKENQRLRPTELGKIISQFLETNFpRIMDIGFTALMEDELELIAD---NKKPWKLLLQEFWELFLPVV-------- 577

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1102546649 302 fsdyqEQKEKEAeksIVGK------CPKCGNNIVLK-----KSFYGCSNYPECKFTLAE 349
Cdd:PRK06319  578 -----VTAEKEA---FIPRivteidCPKCHKGKLVKiwaknRYFYGCSEYPECDYKTSE 628
zf-C4_Topoisom pfam01396
Topoisomerase DNA binding C4 zinc finger;
318-347 1.51e-11

Topoisomerase DNA binding C4 zinc finger;


Pssm-ID: 307520 [Multi-domain]  Cd Length: 39  Bit Score: 58.81  E-value: 1.51e-11
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1102546649 318 VGKCPKCGNNIVLKKS----FYGCSNYPECKFTL 347
Cdd:pfam01396   1 GGKCPKCGGDLVLKRGrfgkFVGCSNYPECRFTR 34
PRK08780 PRK08780
DNA topoisomerase I; Provisional
 2-272 4.60e-11

DNA topoisomerase I; Provisional


Pssm-ID: 181555 [Multi-domain]  Cd Length: 780  Bit Score: 64.78  E-value: 4.60e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649   2 QGLYEA---------KLLSYPRTDTPFITENEFAYLKANFGKYSGFLGLdlemvQTEPRkRYVDGSK-VQE-HHAIIPTK 70
Cdd:PRK08780  289 QKLYEGvdlgdegsvGLITYMRTDSVNLSQDALAEIRDVIARDYGTASL-----PDQPN-TYKTKSKnAQEaHEAVRPTS 362

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649  71 --QVPTESAlAKMDDLQRKIYALVVKTTVAMFLPDYLYEETKIQTKV-ADLLFQSIGKTPKQEGWKILF---KQQTKEEK 144
Cdd:PRK08780  363 alRTPAQVA-RFLSDDQRRLYELIWKRAVACQMIPATLNTVSVDLAAgSEHVFRATGSTVVVPGFLAVYeegKDDKSAED 441

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649 145 ED-VQTLPLVIIGERAEV-GVKSVEKETQPPKAFTEGTLltamktanktvddeeaIKILQEVeGIGTEATRASIIEALKQ 222
Cdd:PRK08780  442 EDeGRKLPPMKEGDNVPLeRIRAEQHFTEPPPRYTEASL----------------VKALEEY-GIGRPSTYASIISTLQF 504

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1102546649 223 KEYIQVIKNKLVVTEKGKLLcQAVESQHL--LTSAEMTAKWETYLKKIGKRE 272
Cdd:PRK08780  505 RKYVEMEGRRFRPTDVGRAV-NKFLTGHFtrYVDYDFTARLEDDLDAVSRGE 555
YrdD COG0551
DNA topoisomerase I, ssDNA-binding Zn-finger and Zn-ribbon domains [Replication, recombination ...
 1-347 5.93e-11

DNA topoisomerase I, ssDNA-binding Zn-finger and Zn-ribbon domains [Replication, recombination and repair];


Pssm-ID: 440317 [Multi-domain]  Cd Length: 695  Bit Score: 64.12  E-value: 5.93e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649   1 MQGLYEAKLLSYPRTDTPFITENEFAYLKANFGKYSGFLGLDLEMVQTEPRKRYVDGSKVQEHHAIIPTKQVPTESALAK 80
Cdd:COG0551   295 LEEEGELLYTGGYIRYTRTPKSSEADALAALEALKKIAEEPPDERAKKKKKKAKKKKASEAKETTDHPPIPPTTAAALLE 374

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649  81 MDDLQRKIYALVVKTTVAMFLPDYLYEETKIQTKVADLLFQSIGKTPKQEGWKilFKQQTKEEKEDVQTLPLVIIGERAE 160
Cdd:COG0551   375 LLEDRKLLLELLVRRRFAAAADLAKVEELTKVEEADEEELVEAEGGLLEVLGE--EEEDDEDEEEELLLPPLEEGEPLLL 452

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649 161 VGVKSVEKETQPPKAFTEGTLLTAMktanktvddeeaikilqEVEGIGTEATRASIIEALKQKEYIQVIKNKLVVTEKGK 240
Cdd:COG0551   453 EELLLEKQTTTPPPRYTTELLLKKL-----------------EEEGGGGRGTTATIIILILKRRYVVLEEKKTTPTELLV 515

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649 241 LLCQAVESQHLLTSAEMTAKWETYLKKIGKREGNQENFITNIKKFIVHLLEAVPNDIEKlnfsdyqEQKEKEAEKSIVGK 320
Cdd:COG0551   516 EVVLLLLLPFPKLEDTTETAEEEEALLDKEEGKEDKVVEIREEEYPFFKKLLEIAEEEG-------EEELSEEDEVLGEK 588

                         330       340       350
                  ....*....|....*....|....*....|.
gi 1102546649 321 CPKCGNNIVLKKS----FYGCSNYPECKFTL 347
Cdd:COG0551   589 CPKCGKPLVIKKGrygkFLGCSNYPECKYTK 619
Toprim_Crpt pfam13342
C-terminal repeat of topoisomerase;
343-397 1.34e-07

C-terminal repeat of topoisomerase;


Pssm-ID: 463851 [Multi-domain]  Cd Length: 60  Bit Score: 47.86  E-value: 1.34e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1102546649 343 CKFTLAEHFRKKKLTKTNVKELLEGKET-LVKGIKNKEKKPYNAVVKIGEKGYIDF 397
Cdd:pfam13342   2 CGFSIGKTIAGKKLSEEQVKELLTKGKTgLIKGFKSKKGKKFDAYLVLDDDEKVEF 57
PTZ00407 PTZ00407
DNA topoisomerase IA; Provisional
 1-276 6.18e-07

DNA topoisomerase IA; Provisional


Pssm-ID: 173597 [Multi-domain]  Cd Length: 805  Bit Score: 51.48  E-value: 6.18e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649   1 MQGLYEAKLLSYPRTDTPFITENE----FAYLKANFGKYSGFLGLDLEMVQTEPRKRYVDGSK---------------VQ 61
Cdd:PTZ00407  347 LQDLFQLGHITYPRTDSTRIDESAlpdiYAAVKKEFGKEFLYRLEDRTVSAQEGKGSKKTGKKrstkqkkgadtpvgnVE 426

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649  62 E-HHAIIPTKQVPTESALAkMDDLQRKIYALVVKTTVAMFLPDYLYEetKIQTKVA-------DLLFQSIGKTPKQEGWK 133
Cdd:PTZ00407  427 DaHEAIRPTNIDTTGESLS-LSPPTRAVYDLVRRNTLAVFMIPMKTE--KIVATVKftsgsgeKLEFELQGKRVVEPGWT 503

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649 134 ILFKQQTK-------EEKEDVQTL----PLV----------IIGERAEVG--VKS----------VEKETQPPKAFTEGT 180
Cdd:PTZ00407  504 RAFHKGDKgttgpaeETDEDITAVeegaPVVpslsqeefkaIMNLRSQLGsgVQKgffelrspqvRENRPVPPLPHSEGT 583

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1102546649 181 LLTAMKTanktvddeeaikilqevEGIGTEATRASIIEALKQKEYIQV-IKNKLVVTEKGKLLCQAVESQH-LLTSAEMT 258
Cdd:PTZ00407  584 LIEELKN-----------------NGVGRPSTYPMIVKTLLARGYIAVnPKGRCETTPVGRMLVETAKSTFpSIVDIGFT 646

                         330
                  ....*....|....*...
gi 1102546649 259 AKWETYLKKIGKREGNQE 276
Cdd:PTZ00407  647 AAFEKKLDRIAKPGPAKR 664
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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