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Conserved domains on  [gi|1109453878|ref|NP_001334490|]
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sodium/calcium exchanger 2 isoform 2 precursor [Mus musculus]

Protein Classification

CaCA family sodium/calcium exchanger( domain architecture ID 11489785)

CaCA family sodium/calcium exchanger mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1-915 0e+00

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


:

Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 1642.21  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109453878   1 MAPLALMGVVLLLGVPHCLGEATPTPSLPPptANDSDASPEGCQGSYRCQPGVLLPVWEPEDPSLGDKVARAVVYFVAMV 80
Cdd:TIGR00845   6 LSPLFSVGFHLLTAVSLLFLHVDHARALTE--ASSSGSNTGECTGSYYCKEGVILPIWEPQNPSVGDKIARATVYFVAMV 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109453878  81 YMFLGVSIIADRFMASIEVITSKEKEITITKANGETSVGTVRIWNETVSNLTLMALGSSAPEILLTVIEVCGHNFQAGEL 160
Cdd:TIGR00845  84 YMFLGVSIIADRFMASIEVITSQEKEITIKKPNGETTVTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFEAGDL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109453878 161 GPGTIVGSAAFNMFVVIAVCVYVIPAGESRKIKHLRVFFVTASWSIFAYVWLYLILAVFSPGVVQVWEALLTLIFFPVCV 240
Cdd:TIGR00845 164 GPSTIVGSAAFNMFIIIAICVYVIPDGETRKIKHLRVFFVTAAWSVFAYVWLYLILAVFSPGVVEVWEGLLTFFFFPLCV 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109453878 241 VFAWMADKRLLFYKYVYKRYRTDPRSGIIIGAEGDPPKS---IELDGTFVGTEVPGELGALGTgpAEARELDASRREVIQ 317
Cdd:TIGR00845 244 VFAWVADRRLLFYKYVYKRYRAGKQRGMIIETEGDRPKSkteIEMDGKMVNSHVDNFLDGALV--LEVKEFDEARREMIR 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109453878 318 ILKDLKQKHPDKDLEQLMGIAKYYALLHQQKSRAFYRIQATRLMTGAGNVLRRHAADAARRPG--ATDGAPDDEDDGASR 395
Cdd:TIGR00845 322 ILKELKQKHPDKDLEQLEEMANYQVLSRQQKSRAFYRIQATRLMTGAGNILKKHAADAARKAVsmHEVATDDEENDPVSK 401

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109453878 396 IFFEPSLYHCLENCGSVLLSVACQGGEGNSTFYVDYRTEDGSAKAGSDYEYSEGTLVFKPGETQKDLRIGIIDDDIFEED 475
Cdd:TIGR00845 402 IFFEPGHYTCLENCGTVALTVVRRGGDLTNTVYVDYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEED 481

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109453878 476 EHFFVRLLNLRVGDAQGMFEPDGGGRpKGRLVAPLLATVTILDDDHAGIFSFQDRLLHVSECMGTVDVRVVRSSGARGTV 555
Cdd:TIGR00845 482 EHFYVRLSNLRVGSEDGILEANHVSA-VAQLASPNTATVTILDDDHAGIFTFEEDVFHVSESIGIMEVKVLRTSGARGTV 560

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109453878 556 RLPYRTVDGTARGGGVHYEDACGELEFGDDETMKTLQVKIVDDEEYEKKDNFFIELGQPQWLKRGIS---------GNGD 626
Cdd:TIGR00845 561 IVPYRTVEGTARGGGKDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIELGEPRWAKRGIKaalllnetiTDDD 640

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109453878 627 KKITAEQEEAQRIAEMGKPVLGENNRLEVIIEESYDFKNTVDKLIKKTNLALVIGTHSWREQFIEAVTVSAG-DEEEDED 705
Cdd:TIGR00845 641 QKLTSKEEEERRIAEMGKPRLGEHTKLEVIIEESYEFKSTVDKLIKKTNLALVVGTHSWREQFIEAITVSAGdDDDDDED 720

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109453878 706 GprEERLPSCFDYVMHFLTVFWKVLFACVPPTEYCNGWACFGVCILVIGVLTALIGDLASHFGCTVGLKDSVNAVVFVAL 785
Cdd:TIGR00845 721 G--EEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWGGWACFVVSILMIGVLTAFIGDLASHFGCTIGLKDSVTAVVFVAL 798

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109453878 786 GTSIPDTFASKVAALQDQCADASIGNVTGSNAVNVFLGLGVAWSVAAVYWAVQGRPFEVRAGTLAFSVTLFTVFAFVCIA 865
Cdd:TIGR00845 799 GTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGTQFKVSPGTLAFSVTLFTIFAFICIG 878

                         890       900       910       920       930
                  ....*....|....*....|....*....|....*....|....*....|
gi 1109453878 866 VLLYRRRPQIGGELGGPRGPKLATTALFLGLWFLYILFSSLEAYCHIRGF 915
Cdd:TIGR00845 879 VLLYRRRPEIGGELGGPRTAKLLTSALFVLLWLLYILFSSLEAYCHIKGF 928
 
Name Accession Description Interval E-value
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1-915 0e+00

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 1642.21  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109453878   1 MAPLALMGVVLLLGVPHCLGEATPTPSLPPptANDSDASPEGCQGSYRCQPGVLLPVWEPEDPSLGDKVARAVVYFVAMV 80
Cdd:TIGR00845   6 LSPLFSVGFHLLTAVSLLFLHVDHARALTE--ASSSGSNTGECTGSYYCKEGVILPIWEPQNPSVGDKIARATVYFVAMV 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109453878  81 YMFLGVSIIADRFMASIEVITSKEKEITITKANGETSVGTVRIWNETVSNLTLMALGSSAPEILLTVIEVCGHNFQAGEL 160
Cdd:TIGR00845  84 YMFLGVSIIADRFMASIEVITSQEKEITIKKPNGETTVTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFEAGDL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109453878 161 GPGTIVGSAAFNMFVVIAVCVYVIPAGESRKIKHLRVFFVTASWSIFAYVWLYLILAVFSPGVVQVWEALLTLIFFPVCV 240
Cdd:TIGR00845 164 GPSTIVGSAAFNMFIIIAICVYVIPDGETRKIKHLRVFFVTAAWSVFAYVWLYLILAVFSPGVVEVWEGLLTFFFFPLCV 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109453878 241 VFAWMADKRLLFYKYVYKRYRTDPRSGIIIGAEGDPPKS---IELDGTFVGTEVPGELGALGTgpAEARELDASRREVIQ 317
Cdd:TIGR00845 244 VFAWVADRRLLFYKYVYKRYRAGKQRGMIIETEGDRPKSkteIEMDGKMVNSHVDNFLDGALV--LEVKEFDEARREMIR 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109453878 318 ILKDLKQKHPDKDLEQLMGIAKYYALLHQQKSRAFYRIQATRLMTGAGNVLRRHAADAARRPG--ATDGAPDDEDDGASR 395
Cdd:TIGR00845 322 ILKELKQKHPDKDLEQLEEMANYQVLSRQQKSRAFYRIQATRLMTGAGNILKKHAADAARKAVsmHEVATDDEENDPVSK 401

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109453878 396 IFFEPSLYHCLENCGSVLLSVACQGGEGNSTFYVDYRTEDGSAKAGSDYEYSEGTLVFKPGETQKDLRIGIIDDDIFEED 475
Cdd:TIGR00845 402 IFFEPGHYTCLENCGTVALTVVRRGGDLTNTVYVDYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEED 481

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109453878 476 EHFFVRLLNLRVGDAQGMFEPDGGGRpKGRLVAPLLATVTILDDDHAGIFSFQDRLLHVSECMGTVDVRVVRSSGARGTV 555
Cdd:TIGR00845 482 EHFYVRLSNLRVGSEDGILEANHVSA-VAQLASPNTATVTILDDDHAGIFTFEEDVFHVSESIGIMEVKVLRTSGARGTV 560

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109453878 556 RLPYRTVDGTARGGGVHYEDACGELEFGDDETMKTLQVKIVDDEEYEKKDNFFIELGQPQWLKRGIS---------GNGD 626
Cdd:TIGR00845 561 IVPYRTVEGTARGGGKDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIELGEPRWAKRGIKaalllnetiTDDD 640

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109453878 627 KKITAEQEEAQRIAEMGKPVLGENNRLEVIIEESYDFKNTVDKLIKKTNLALVIGTHSWREQFIEAVTVSAG-DEEEDED 705
Cdd:TIGR00845 641 QKLTSKEEEERRIAEMGKPRLGEHTKLEVIIEESYEFKSTVDKLIKKTNLALVVGTHSWREQFIEAITVSAGdDDDDDED 720

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109453878 706 GprEERLPSCFDYVMHFLTVFWKVLFACVPPTEYCNGWACFGVCILVIGVLTALIGDLASHFGCTVGLKDSVNAVVFVAL 785
Cdd:TIGR00845 721 G--EEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWGGWACFVVSILMIGVLTAFIGDLASHFGCTIGLKDSVTAVVFVAL 798

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109453878 786 GTSIPDTFASKVAALQDQCADASIGNVTGSNAVNVFLGLGVAWSVAAVYWAVQGRPFEVRAGTLAFSVTLFTVFAFVCIA 865
Cdd:TIGR00845 799 GTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGTQFKVSPGTLAFSVTLFTIFAFICIG 878

                         890       900       910       920       930
                  ....*....|....*....|....*....|....*....|....*....|
gi 1109453878 866 VLLYRRRPQIGGELGGPRGPKLATTALFLGLWFLYILFSSLEAYCHIRGF 915
Cdd:TIGR00845 879 VLLYRRRPEIGGELGGPRTAKLLTSALFVLLWLLYILFSSLEAYCHIKGF 928
Na_Ca_ex_C pfam16494
C-terminal extension of sodium/calcium exchanger domain; Na_Ca_ex_C is a region of the higher ...
 248-368 1.68e-66

C-terminal extension of sodium/calcium exchanger domain; Na_Ca_ex_C is a region of the higher eukaryote sodium/calcium exchanger domain that extends toward the C-terminal, and is cytoplasmic.


Pssm-ID: 465141  Cd Length: 136  Bit Score: 218.33  E-value: 1.68e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109453878 248 KRLLFYKYVYKRYRTDPRSGIIIGAEGDPPKS----IELDGTFVGTEVPGELGALGTGPAEARELDASRREVIQILKDLK 323
Cdd:pfam16494   1 RRLLFYKYLYKRYRADKRRGIIVETEGELGPKegieMLMDGKLVGSHVMEGGAEGPVDDPEAKELDEARREVIRILKELK 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1109453878 324 QKHPDKDLEQLMGIAKYYALLHQQKSRAFYRIQATRLMTGAGNVL 368
Cdd:pfam16494  81 QKHPDKDLEQLEEMANYEALSHQPKSRAFYRIQATRKMTGAGNIL 125
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 522-612 1.16e-33

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 124.29  E-value: 1.16e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109453878  522 AGIFSFQDRLLHVSECMGTVDVRVVRSSGARGTVRLPYRTVDGTARGGgVHYEDACGELEFGDDETMKTLQVKIVDDEEY 601
Cdd:smart00237   1 AGSVGFEQPVYTVSESDGEVEVCVVRTGGARGPVVVPYSTEDGTATAG-SDYEPVPGELTFPPGETEKEIRIKIIDDDIY 79

                           90
                   ....*....|.
gi 1109453878  602 EKKDNFFIELG 612
Cdd:smart00237  80 EKDETFYVRLS 90
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
742-903 1.61e-13

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 72.09  E-value: 1.61e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109453878 742 GWACFGVCILVIG--VLTALIGDLASHFGctvgLKDSVNAVVFVALGTSIPDTFASKVAALQDQcADASIGNVTGSNAVN 819
Cdd:COG0530   155 LLLVLGLALLVVGarLLVDGAVEIARALG----VSELVIGLTIVAIGTSLPELATSIVAARKGE-DDLAVGNIIGSNIFN 229

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109453878 820 VFLGLGvawsVAAVYwavqgRPFEVRAGTLAFSVTLFTVFAFVCIAVLLYRRRpqiggeLGGPRGpklattALFLGLWFL 899
Cdd:COG0530   230 ILLVLG----IGALI-----TPIPVDPAVLSFDLPVMLAATLLLLGLLRTGGR------IGRWEG------LLLLALYLA 288


                  ....
gi 1109453878 900 YILF 903
Cdd:COG0530   289 YLAL 292
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 764-867 1.22e-04

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 45.02  E-value: 1.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109453878 764 ASHFGCTVGLKDSVNAVVFVALGTSIPDTFASKVAALQDQcADASIGNVTGSNAVNVFLGLGVAWSVaavywavqgRPFE 843
Cdd:PRK10734   26 ASILCRTFGIPPLIIGMTVVGIGTSLPEIIVSVAASLHGQ-RDLAVGTALGSNITNILLILGLAALI---------RPFT 95

                          90       100
                  ....*....|....*....|....
gi 1109453878 844 VRAGTLAFSVTLFTVFAFVCIAVL 867
Cdd:PRK10734   96 VHSDVLRRELPLMLLVSVLAGSVL 119
 
Name Accession Description Interval E-value
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1-915 0e+00

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 1642.21  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109453878   1 MAPLALMGVVLLLGVPHCLGEATPTPSLPPptANDSDASPEGCQGSYRCQPGVLLPVWEPEDPSLGDKVARAVVYFVAMV 80
Cdd:TIGR00845   6 LSPLFSVGFHLLTAVSLLFLHVDHARALTE--ASSSGSNTGECTGSYYCKEGVILPIWEPQNPSVGDKIARATVYFVAMV 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109453878  81 YMFLGVSIIADRFMASIEVITSKEKEITITKANGETSVGTVRIWNETVSNLTLMALGSSAPEILLTVIEVCGHNFQAGEL 160
Cdd:TIGR00845  84 YMFLGVSIIADRFMASIEVITSQEKEITIKKPNGETTVTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFEAGDL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109453878 161 GPGTIVGSAAFNMFVVIAVCVYVIPAGESRKIKHLRVFFVTASWSIFAYVWLYLILAVFSPGVVQVWEALLTLIFFPVCV 240
Cdd:TIGR00845 164 GPSTIVGSAAFNMFIIIAICVYVIPDGETRKIKHLRVFFVTAAWSVFAYVWLYLILAVFSPGVVEVWEGLLTFFFFPLCV 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109453878 241 VFAWMADKRLLFYKYVYKRYRTDPRSGIIIGAEGDPPKS---IELDGTFVGTEVPGELGALGTgpAEARELDASRREVIQ 317
Cdd:TIGR00845 244 VFAWVADRRLLFYKYVYKRYRAGKQRGMIIETEGDRPKSkteIEMDGKMVNSHVDNFLDGALV--LEVKEFDEARREMIR 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109453878 318 ILKDLKQKHPDKDLEQLMGIAKYYALLHQQKSRAFYRIQATRLMTGAGNVLRRHAADAARRPG--ATDGAPDDEDDGASR 395
Cdd:TIGR00845 322 ILKELKQKHPDKDLEQLEEMANYQVLSRQQKSRAFYRIQATRLMTGAGNILKKHAADAARKAVsmHEVATDDEENDPVSK 401

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109453878 396 IFFEPSLYHCLENCGSVLLSVACQGGEGNSTFYVDYRTEDGSAKAGSDYEYSEGTLVFKPGETQKDLRIGIIDDDIFEED 475
Cdd:TIGR00845 402 IFFEPGHYTCLENCGTVALTVVRRGGDLTNTVYVDYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEED 481

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109453878 476 EHFFVRLLNLRVGDAQGMFEPDGGGRpKGRLVAPLLATVTILDDDHAGIFSFQDRLLHVSECMGTVDVRVVRSSGARGTV 555
Cdd:TIGR00845 482 EHFYVRLSNLRVGSEDGILEANHVSA-VAQLASPNTATVTILDDDHAGIFTFEEDVFHVSESIGIMEVKVLRTSGARGTV 560

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109453878 556 RLPYRTVDGTARGGGVHYEDACGELEFGDDETMKTLQVKIVDDEEYEKKDNFFIELGQPQWLKRGIS---------GNGD 626
Cdd:TIGR00845 561 IVPYRTVEGTARGGGKDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIELGEPRWAKRGIKaalllnetiTDDD 640

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109453878 627 KKITAEQEEAQRIAEMGKPVLGENNRLEVIIEESYDFKNTVDKLIKKTNLALVIGTHSWREQFIEAVTVSAG-DEEEDED 705
Cdd:TIGR00845 641 QKLTSKEEEERRIAEMGKPRLGEHTKLEVIIEESYEFKSTVDKLIKKTNLALVVGTHSWREQFIEAITVSAGdDDDDDED 720

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109453878 706 GprEERLPSCFDYVMHFLTVFWKVLFACVPPTEYCNGWACFGVCILVIGVLTALIGDLASHFGCTVGLKDSVNAVVFVAL 785
Cdd:TIGR00845 721 G--EEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWGGWACFVVSILMIGVLTAFIGDLASHFGCTIGLKDSVTAVVFVAL 798

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109453878 786 GTSIPDTFASKVAALQDQCADASIGNVTGSNAVNVFLGLGVAWSVAAVYWAVQGRPFEVRAGTLAFSVTLFTVFAFVCIA 865
Cdd:TIGR00845 799 GTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGTQFKVSPGTLAFSVTLFTIFAFICIG 878

                         890       900       910       920       930
                  ....*....|....*....|....*....|....*....|....*....|
gi 1109453878 866 VLLYRRRPQIGGELGGPRGPKLATTALFLGLWFLYILFSSLEAYCHIRGF 915
Cdd:TIGR00845 879 VLLYRRRPEIGGELGGPRTAKLLTSALFVLLWLLYILFSSLEAYCHIKGF 928
Na_Ca_ex_C pfam16494
C-terminal extension of sodium/calcium exchanger domain; Na_Ca_ex_C is a region of the higher ...
 248-368 1.68e-66

C-terminal extension of sodium/calcium exchanger domain; Na_Ca_ex_C is a region of the higher eukaryote sodium/calcium exchanger domain that extends toward the C-terminal, and is cytoplasmic.


Pssm-ID: 465141  Cd Length: 136  Bit Score: 218.33  E-value: 1.68e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109453878 248 KRLLFYKYVYKRYRTDPRSGIIIGAEGDPPKS----IELDGTFVGTEVPGELGALGTGPAEARELDASRREVIQILKDLK 323
Cdd:pfam16494   1 RRLLFYKYLYKRYRADKRRGIIVETEGELGPKegieMLMDGKLVGSHVMEGGAEGPVDDPEAKELDEARREVIRILKELK 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1109453878 324 QKHPDKDLEQLMGIAKYYALLHQQKSRAFYRIQATRLMTGAGNVL 368
Cdd:pfam16494  81 QKHPDKDLEQLEEMANYEALSHQPKSRAFYRIQATRKMTGAGNIL 125
Calx-beta pfam03160
Calx-beta domain;
393-482 5.02e-38

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 136.61  E-value: 5.02e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109453878 393 ASRIFFEPSLYHCLENCGSVLLSVACQGGEGNSTFYVDYRTEDGSAKAGSDYEYSEGTLVFKPGETQKDLRIGIIDDDIF 472
Cdd:pfam03160   1 AGVIGFEPPTYQVSENDGVAEVCVVRMSGTLRRTVVVPYRTEDGTATAGDDYEPVEGELVFGPGETEKCINVTIIDDDVY 80

                          90
                  ....*....|
gi 1109453878 473 EEDEHFFVRL 482
Cdd:pfam03160  81 EGDENFFVLL 90
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 522-612 1.16e-33

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 124.29  E-value: 1.16e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109453878  522 AGIFSFQDRLLHVSECMGTVDVRVVRSSGARGTVRLPYRTVDGTARGGgVHYEDACGELEFGDDETMKTLQVKIVDDEEY 601
Cdd:smart00237   1 AGSVGFEQPVYTVSESDGEVEVCVVRTGGARGPVVVPYSTEDGTATAG-SDYEPVPGELTFPPGETEKEIRIKIIDDDIY 79

                           90
                   ....*....|.
gi 1109453878  602 EKKDNFFIELG 612
Cdd:smart00237  80 EKDETFYVRLS 90
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 393-483 1.92e-33

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 123.52  E-value: 1.92e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109453878  393 ASRIFFEPSLYHCLENCGSVLLSVACQGGeGNSTFYVDYRTEDGSAKAGSDYEYSEGTLVFKPGETQKDLRIGIIDDDIF 472
Cdd:smart00237   1 AGSVGFEQPVYTVSESDGEVEVCVVRTGG-ARGPVVVPYSTEDGTATAGSDYEPVPGELTFPPGETEKEIRIKIIDDDIY 79

                           90
                   ....*....|.
gi 1109453878  473 EEDEHFFVRLL 483
Cdd:smart00237  80 EKDETFYVRLS 90
Calx-beta pfam03160
Calx-beta domain;
522-612 4.41e-31

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 116.97  E-value: 4.41e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109453878 522 AGIFSFQDRLLHVSECMGTVDVRVVRSSGA-RGTVRLPYRTVDGTARGGgVHYEDACGELEFGDDETMKTLQVKIVDDEE 600
Cdd:pfam03160   1 AGVIGFEPPTYQVSENDGVAEVCVVRMSGTlRRTVVVPYRTEDGTATAG-DDYEPVEGELVFGPGETEKCINVTIIDDDV 79

                          90
                  ....*....|..
gi 1109453878 601 YEKKDNFFIELG 612
Cdd:pfam03160  80 YEGDENFFVLLS 91
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 742-906 2.36e-23

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 96.90  E-value: 2.36e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109453878 742 GWACFGVCILVIGVLTALIGDLASHFGCTVGLKDSVNAVVFVALGTSIPDTFASKVAALQDQcADASIGNVTGSNAVNVF 821
Cdd:pfam01699   2 SLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGE-PDLALGNVIGSNIFNIL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109453878 822 LGLGVAWSVAAVYWAVQGRPFEvragtlaFSVTLFTVFAFVCIAVLLYRRRpqiggelggPRGPKLATTALFLGLWFLYI 901
Cdd:pfam01699  81 LVLGLSALIGPVKVDSLLLKLD-------LGVLLLVALLLLLLLLLLLLPL---------FGRLSRFEGLVLLLLYIVYL 144


                  ....*
gi 1109453878 902 LFSSL 906
Cdd:pfam01699 145 VFQIV 149
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 74-245 2.27e-19

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 85.73  E-value: 2.27e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109453878  74 VYFVAMVYMFLGVSIIADRFMASIEVItskekeititkangetsvGTVRIWNETVSNLTLMALGSSAPEILLTVIEVCGH 153
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVL------------------ARVLGISGTVLGLTILALGTSLPELVSSIIAALRG 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109453878 154 NfqaGELGPGTIVGSAAFNMFVVIAVCVYVIPA--GESRKIKHLRVFFVTASWSIFAYVWLYLILavfsPGVVQVWEALL 231
Cdd:pfam01699  63 E---PDLALGNVIGSNIFNILLVLGLSALIGPVkvDSLLLKLDLGVLLLVALLLLLLLLLLLLPL----FGRLSRFEGLV 135

                         170
                  ....*....|....
gi 1109453878 232 TLIFFPVCVVFAWM 245
Cdd:pfam01699 136 LLLLYIVYLVFQIV 149
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
742-903 1.61e-13

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 72.09  E-value: 1.61e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109453878 742 GWACFGVCILVIG--VLTALIGDLASHFGctvgLKDSVNAVVFVALGTSIPDTFASKVAALQDQcADASIGNVTGSNAVN 819
Cdd:COG0530   155 LLLVLGLALLVVGarLLVDGAVEIARALG----VSELVIGLTIVAIGTSLPELATSIVAARKGE-DDLAVGNIIGSNIFN 229

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109453878 820 VFLGLGvawsVAAVYwavqgRPFEVRAGTLAFSVTLFTVFAFVCIAVLLYRRRpqiggeLGGPRGpklattALFLGLWFL 899
Cdd:COG0530   230 ILLVLG----IGALI-----TPIPVDPAVLSFDLPVMLAATLLLLGLLRTGGR------IGRWEG------LLLLALYLA 288


                  ....
gi 1109453878 900 YILF 903
Cdd:COG0530   289 YLAL 292
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 73-314 6.84e-12

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 69.64  E-value: 6.84e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109453878   73 VVYFVAMVYMFLGVSIIADR-FMASIEVITSKekeititkangetsvgtVRIwNETVSNLTLMALGSSAPEILLTVIEV- 150
Cdd:TIGR00927  458 VLHIFGMMYVFVALAIVCDEyFVPALGVITDK-----------------LQI-SEDVAGATFMAAGGSAPELFTSLIGVf 519

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109453878  151 CGHNfqagELGPGTIVGSAAFNMFVVIAVCvyvipAGESRKIKHLrvffvtASWSIFAYVWLY-----LILAVFSPGVVQ 225
Cdd:TIGR00927  520 ISHS----NVGIGTIVGSAVFNILFVIGTC-----ALFSREILNL------TWWPLFRDVSFYildlmMLILFFLDSLIA 584

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109453878  226 VWEALLTLIFFPVcVVFAWMADKRLlfYKYVYKRYRTDPRSGIIigAEGDPPKSIELDGTFVGTEVPGELGALGTGPAEA 305
Cdd:TIGR00927  585 WWESLLLLLAYAL-YVFTMKWNKQI--ELWVKEQLSRRPVAKVM--ALGDLSKGDVAEAEHTGERTGEEGERPTEAEGEN 659


                   ....*....
gi 1109453878  306 RELDASRRE 314
Cdd:TIGR00927  660 GEESGGEAE 668
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
763-904 3.72e-10

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 62.07  E-value: 3.72e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109453878 763 LASHFGctvgLKDSVNAVVFVALGTSIPDTFASKVAALQDQcADASIGNVTGSNAVNVFLGLGvawsVAAVYwavqgRPF 842
Cdd:COG0530    11 LARRLG----ISPLVIGLTIVAFGTSLPELAVSVTAALDGS-PDIAVGNVVGSNIANILLILG----LAALI-----RPL 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1109453878 843 EVRAGTLAFSVTLFTVFAFVCIAVLLYRRRPQIGGelggprgpklattALFLGLWFLYILFS 904
Cdd:COG0530    77 AVDRRVLRRDLPFLLLASLLLLALLLDGTLSRIDG-------------VILLLLYVLYLYYL 125
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
131-249 4.11e-08

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 55.91  E-value: 4.11e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109453878 131 LTLMALGSSAPEILLTVIEVCGHNFqagELGPGTIVGSAAFNMFVVIAVCVYVIPAgesrKIKHlRVFFVTASWSIFAYV 210
Cdd:COG0530    24 LTIVAFGTSLPELAVSVTAALDGSP---DIAVGNVVGSNIANILLILGLAALIRPL----AVDR-RVLRRDLPFLLLASL 95

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1109453878 211 wlyLILAVFSPGVVQVWEALLTLIFFPVCVVFAWMADKR 249
Cdd:COG0530    96 ---LLLALLLDGTLSRIDGVILLLLYVLYLYYLIRRARK 131
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 743-900 2.21e-06

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 50.40  E-value: 2.21e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109453878 743 WACFGVCILVIGvlTALIGDLASHFGCTVGLKDSVNAVVFVALGTSIPDTFASKVAALQDQCaDASIGNVTGSNAVNVFL 822
Cdd:TIGR00367 174 LLIIGLIGLVVG--SRLLVDGAVKIAEILGISEKIIGLTLLAIGTSLPELVVSLAAARKGLG-DIAVGNVIGSNIFNILV 250

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1109453878 823 GLGVAWSVAAVywavqgrPFEVRAGTLAFSVTLFTVFAFvciaVLLYRRRPQIGGELGgprgpklattALFLGLWFLY 900
Cdd:TIGR00367 251 GLGVPSLFMPI-------PVEPLAYNLDAPVMVIVTLLL----MLFFKTSMKLGRWEG----------ILLLALYIAY 307
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 762-900 1.11e-05

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 48.47  E-value: 1.11e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109453878 762 DLASHFGctvgLKDSVNAVVFVALGTSIPDTFASKVAALQDQcADASIGNVTGSNAVNVFLGLGVAWSVaavywavqgRP 841
Cdd:TIGR00367  27 RIARHLG----ISPLIIGVTVVAIGTSLPELFTSLIASLMGQ-PDIGVGNVIGSNIFNILLILGLSAIF---------SP 92

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1109453878 842 FEVRAGTLAFSVTLFTVFAFVCIAVLLYrrrpqiggelgGPRGPKLATTALFLG---LWFLY 900
Cdd:TIGR00367  93 IIVDKDWLRRDILFYLLVSILLLFFGLD-----------GQISRIDGVVLLILYivyLLFLV 143
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 77-244 5.97e-05

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 46.16  E-value: 5.97e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109453878  77 VAMVYMFLGVSII-ADRFMASIEVITSKEKEITItkangetsvgtvriwnetVSNLTLMALGSSAPEILLTVIEVCGHNf 155
Cdd:TIGR00367   4 IGYLILGLILLIYgADLFVKSSVRIARHLGISPL------------------IIGVTVVAIGTSLPELFTSLIASLMGQ- 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109453878 156 qaGELGPGTIVGSAAFNMFVVIAVCVYVIPagesrkikhlrvfFVTASWSIF----AYVWLYLILAVFspGVVQVWEALL 231
Cdd:TIGR00367  65 --PDIGVGNVIGSNIFNILLILGLSAIFSP-------------IIVDKDWLRrdilFYLLVSILLLFF--GLDGQISRID 127

                         170
                  ....*....|...
gi 1109453878 232 TLIFFPVCVVFAW 244
Cdd:TIGR00367 128 GVVLLILYIVYLL 140
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 764-867 1.22e-04

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 45.02  E-value: 1.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109453878 764 ASHFGCTVGLKDSVNAVVFVALGTSIPDTFASKVAALQDQcADASIGNVTGSNAVNVFLGLGVAWSVaavywavqgRPFE 843
Cdd:PRK10734   26 ASILCRTFGIPPLIIGMTVVGIGTSLPEIIVSVAASLHGQ-RDLAVGTALGSNITNILLILGLAALI---------RPFT 95

                          90       100
                  ....*....|....*....|....
gi 1109453878 844 VRAGTLAFSVTLFTVFAFVCIAVL 867
Cdd:PRK10734   96 VHSDVLRRELPLMLLVSVLAGSVL 119
PLN03151 PLN03151
cation/calcium exchanger; Provisional
 127-263 1.59e-03

cation/calcium exchanger; Provisional


Pssm-ID: 215604 [Multi-domain]  Cd Length: 650  Bit Score: 42.06  E-value: 1.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109453878 127 TVSNLTLMALGSSAPEILLTVIEVCGHNfqAGELGPGTIVGSAAFNMFVV---IAVCVyvipAGESRKIKHlRVFFVTAS 203
Cdd:PLN03151  178 TVAGVTLLPLGNGAPDVFASIAAFVGKD--AGEVGLNSVLGGAVFVTCVVvgiVSLCV----ADKEVQIDK-RCFIRDLC 250

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109453878 204 WSIFAYVWLYLILAVfspGVVQVWEAlltLIFFPVCVVFAWMADKRLLFYKYVyKRYRTD 263
Cdd:PLN03151  251 FFLFTLVSLLVILMV---GKVTVGGA---IAFVSIYVVYAFLVAANEILRKHA-RRLKLD 303
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
124-242 4.61e-03

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 40.12  E-value: 4.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109453878 124 WNETVSNLTLMALGSSAPEILLTVIEVcghnFQ-AGELGPGTIVGSAAFNMFVVIAVCVYVIPagesrkikhLRVFFVTA 202
Cdd:COG0530   184 VSELVIGLTIVAIGTSLPELATSIVAA----RKgEDDLAVGNIIGSNIFNILLVLGIGALITP---------IPVDPAVL 250

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1109453878 203 SWSIFAYV--WLYLILAVFSPGVVQVWEALLTLIFFPVCVVF 242
Cdd:COG0530   251 SFDLPVMLaaTLLLLGLLRTGGRIGRWEGLLLLALYLAYLAL 292
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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