NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1111957604|ref|XP_721915|]
View 

protein-lysine N-methyltransferase [Candida albicans SC5314]

Protein Classification

SETD4 family SET domain-containing protein( domain architecture ID 14442830)

SETD4 family SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain-containing protein similar to the SET domain region of Homo sapiens SET domain-containing protein 4 (SETD4), a histone-lysine N-methyltransferase that acts as a regulator of cell proliferation, cell differentiation and inflammatory response

CATH:  2.170.270.10
EC:  2.1.1.-
Gene Ontology:  GO:0005515|GO:1904047|GO:0016279
PubMed:  12372294|17013555
SCOP:  3000162

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
SET_SETD4 cd19177
SET domain found in SET domain-containing protein 4 (SETD4) and similar proteins; SETD4 is a ...
 31-296 4.05e-74

SET domain found in SET domain-containing protein 4 (SETD4) and similar proteins; SETD4 is a cytosolic and nuclear functional lysine methyltransferase that plays a crucial role in breast carcinogenesis. However, its specific substrates and modification sites remain to be disclosed.


:

Pssm-ID: 380954 [Multi-domain]  Cd Length: 245  Bit Score: 232.19  E-value: 4.05e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1111957604  31 ISPKIDVKDVRSSGRGIYAVEPLKKGELILNIPHSFLLNFTTVMAHIVKYNgmaidshihvpfdksedeyteiyrtlTKE 110
Cdd:cd19177     1 KSSKLKPAEFPDTGRGLVATKDIKPGELIISIPESLLINTTTVLSSLLGSL--------------------------IKR 54

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1111957604 111 EILELSSFQLLSLYLTFERKRSHKSFWKPFLDMLPSmdDFELMPIDWPQEVCTLLPSS----TEVRNKKVRSRFDNDYQV 186
Cdd:cd19177    55 VKPKLSSLQLLALFLALEKRRGENSFWAPYLDSLPK--SFDTHPLYWSLEELSLLPPSlleaVRKLLDKQKKRFESDWEI 132

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1111957604 187 ICELIKTKIDKDGdvTTLLPRQEVLLSWLCINSRCLYMDLPTSKN---SADNFTMAPYVDFMNHSCDDHCTL--KIDGKG 261
Cdd:cd19177   133 ISSVLKSLPSLFD--SEIFTLEEFRWAWLCVNTRCVYYKLPLSDYlssSEDNIALAPFLDLLNHSPDVNVKAgfNKSGKC 210

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1111957604 262 FQVRTTSQYNTGDQVYLSYGPHSNDFLLCEYGFVI 296
Cdd:cd19177   211 YEIRTGTDYKKGEEVFISYGPHSNDFLLLEYGFVL 245
 
Name Accession Description Interval E-value
SET_SETD4 cd19177
SET domain found in SET domain-containing protein 4 (SETD4) and similar proteins; SETD4 is a ...
 31-296 4.05e-74

SET domain found in SET domain-containing protein 4 (SETD4) and similar proteins; SETD4 is a cytosolic and nuclear functional lysine methyltransferase that plays a crucial role in breast carcinogenesis. However, its specific substrates and modification sites remain to be disclosed.


Pssm-ID: 380954 [Multi-domain]  Cd Length: 245  Bit Score: 232.19  E-value: 4.05e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1111957604  31 ISPKIDVKDVRSSGRGIYAVEPLKKGELILNIPHSFLLNFTTVMAHIVKYNgmaidshihvpfdksedeyteiyrtlTKE 110
Cdd:cd19177     1 KSSKLKPAEFPDTGRGLVATKDIKPGELIISIPESLLINTTTVLSSLLGSL--------------------------IKR 54

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1111957604 111 EILELSSFQLLSLYLTFERKRSHKSFWKPFLDMLPSmdDFELMPIDWPQEVCTLLPSS----TEVRNKKVRSRFDNDYQV 186
Cdd:cd19177    55 VKPKLSSLQLLALFLALEKRRGENSFWAPYLDSLPK--SFDTHPLYWSLEELSLLPPSlleaVRKLLDKQKKRFESDWEI 132

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1111957604 187 ICELIKTKIDKDGdvTTLLPRQEVLLSWLCINSRCLYMDLPTSKN---SADNFTMAPYVDFMNHSCDDHCTL--KIDGKG 261
Cdd:cd19177   133 ISSVLKSLPSLFD--SEIFTLEEFRWAWLCVNTRCVYYKLPLSDYlssSEDNIALAPFLDLLNHSPDVNVKAgfNKSGKC 210

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1111957604 262 FQVRTTSQYNTGDQVYLSYGPHSNDFLLCEYGFVI 296
Cdd:cd19177   211 YEIRTGTDYKKGEEVFISYGPHSNDFLLLEYGFVL 245
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 213-281 6.02e-04

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 39.43  E-value: 6.02e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1111957604 213 SWLCINSRCLYMDLPTsknsadnftmapyvDFMNHSCDDHCTLKID----GKGFQVRTTSQYNTGDQVYLSYG 281
Cdd:pfam00856  57 SEYCIDARALYYGNWA--------------RFINHSCDPNCEVRVVyvngGPRIVIFALRDIKPGEELTIDYG 115
 
Name Accession Description Interval E-value
SET_SETD4 cd19177
SET domain found in SET domain-containing protein 4 (SETD4) and similar proteins; SETD4 is a ...
 31-296 4.05e-74

SET domain found in SET domain-containing protein 4 (SETD4) and similar proteins; SETD4 is a cytosolic and nuclear functional lysine methyltransferase that plays a crucial role in breast carcinogenesis. However, its specific substrates and modification sites remain to be disclosed.


Pssm-ID: 380954 [Multi-domain]  Cd Length: 245  Bit Score: 232.19  E-value: 4.05e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1111957604  31 ISPKIDVKDVRSSGRGIYAVEPLKKGELILNIPHSFLLNFTTVMAHIVKYNgmaidshihvpfdksedeyteiyrtlTKE 110
Cdd:cd19177     1 KSSKLKPAEFPDTGRGLVATKDIKPGELIISIPESLLINTTTVLSSLLGSL--------------------------IKR 54

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1111957604 111 EILELSSFQLLSLYLTFERKRSHKSFWKPFLDMLPSmdDFELMPIDWPQEVCTLLPSS----TEVRNKKVRSRFDNDYQV 186
Cdd:cd19177    55 VKPKLSSLQLLALFLALEKRRGENSFWAPYLDSLPK--SFDTHPLYWSLEELSLLPPSlleaVRKLLDKQKKRFESDWEI 132

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1111957604 187 ICELIKTKIDKDGdvTTLLPRQEVLLSWLCINSRCLYMDLPTSKN---SADNFTMAPYVDFMNHSCDDHCTL--KIDGKG 261
Cdd:cd19177   133 ISSVLKSLPSLFD--SEIFTLEEFRWAWLCVNTRCVYYKLPLSDYlssSEDNIALAPFLDLLNHSPDVNVKAgfNKSGKC 210

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1111957604 262 FQVRTTSQYNTGDQVYLSYGPHSNDFLLCEYGFVI 296
Cdd:cd19177   211 YEIRTGTDYKKGEEVFISYGPHSNDFLLLEYGFVL 245
SET_LSMT cd10527
SET domain found in Rubisco large subunit methyltransferase (LSMT) and similar proteins; ...
 34-295 7.38e-46

SET domain found in Rubisco large subunit methyltransferase (LSMT) and similar proteins; Rubisco LSMT is a non-histone protein methyl transferase responsible for the trimethylation of lysine14 in the large subunit of Rubisco (ribulose-1,5-bisphosphate carboxylase/oxygenase). The family also includes SET domain-containing proteins, SETD3, SETD4 and SETD6, which belong to methyltransferase class VII that represents classical non-histone SET domain methyltransferases. Members in this family contain a SET domain and a C-terminal RubisCO LSMT substrate-binding (Rubis-subs-bind) domain.


Pssm-ID: 380925 [Multi-domain]  Cd Length: 236  Bit Score: 158.38  E-value: 7.38e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1111957604  34 KIDVKDVRSSGRGIYAVEPLKKGELILNIPHSFLLNFTTVMAHIVKYNGMAIDshihvpfdksedeyteiyrtltkEEIL 113
Cdd:cd10527     1 GVELAESPDGGRGLFATRDIAAGEVLLSVPRSLLLTVETARESPLGGAALALL-----------------------ELDP 57

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1111957604 114 ELSSFQLLSLYLTFERKRSHKSFWKPFLDMLPSmdDFELMPIDWPQEVCTLLPSSTEVRN-KKVRSRFDNDYQVICELIK 192
Cdd:cd10527    58 ELSWDVALALFLLYERARGPDSFWAPYLDSLPR--PFEDTPLFWSEEELDALQGTPLLEAaAAQRRRLREEYEALVEALP 135

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1111957604 193 TKIDKDGDVTtlLPRQEVLLSWLCINSRCLYMDLPtskNSADNFTMAPYVDFMNHSCDDH-CTLKIDGKG--FQVRTTSQ 269
Cdd:cd10527   136 EALPAEPGEA--FTLEEFLWALALVLSRAFSLPVP---DGGGGLALVPLADMLNHSPDAPnVRYEYDEDEgsFVLVATRD 210

                         250       260
                  ....*....|....*....|....*.
gi 1111957604 270 YNTGDQVYLSYGPHSNDFLLCEYGFV 295
Cdd:cd10527   211 IAAGEEVFISYGPKSNDELLLYYGFV 236
SET_RBCMT cd19179
SET domain found in chloroplastic ribulose-1,5 bisphosphate carboxylase/oxygenase large ...
 39-295 9.69e-27

SET domain found in chloroplastic ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase (RBCMT) and similar proteins; RBCMT (EC 2.1.1.127; also termed [Ribulose-bisphosphate carboxylase]-lysine N-methyltransferase, RuBisCO LSMT, RuBisCO methyltransferase, or rbcMT) methylates 'Lys-14' of the large subunit of RuBisCO.


Pssm-ID: 380956  Cd Length: 237  Bit Score: 107.40  E-value: 9.69e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1111957604  39 DVRSSGRGIYAVEPLKKGELILNIPHSFLLNFTTVMAHIVKYNGMAidshihvpfdksedeyteiyrtltkeeilELSSF 118
Cdd:cd19179    12 DEEAGGRGLVAARPIRRGERLLSVPESLWITAETAARSEIGGVLES-----------------------------GLKPW 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1111957604 119 QLLSLYLTFERKRSHKSFWKPFLDMLPSMDDFElMPIDWPQ-EVCTLLPSSTEVRNKKVRSRFDNDYQVICELIKTKIDK 197
Cdd:cd19179    63 LALALFLLRERSRGEASFWAPYIAVLPKEEELD-SPLLWSEeELAELLGSPLLAATAERKAYVRAEYEALLEAVFEKNPK 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1111957604 198 dgdvttLLPRQEVLLS---W----LCinSRCLYMDLPtsknsaDNFTMAPYVDFMNHSCDDHCTLKIDGKGFQ-----VR 265
Cdd:cd19179   142 ------VFPPEVFTLEafkWafgiLF--SRAFSLLAG------GTLALVPWADLLNHSSGVSSDASYDVRGGSskavvLT 207

                         250       260       270
                  ....*....|....*....|....*....|
gi 1111957604 266 TTSQYNTGDQVYLSYGPHSNDFLLCEYGFV 295
Cdd:cd19179   208 ADRNYSAGEQVFISYGPKSNAELLLDYGFV 237
SET_SpSET10-like cd19180
SET domain found in Schizosaccharomyces pombe SET domain-containing protein 10 (SETD10) and ...
 13-295 2.96e-24

SET domain found in Schizosaccharomyces pombe SET domain-containing protein 10 (SETD10) and similar proteins; Schizosaccharomyces pombe SETD10 is a ribosomal S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates ribosomal protein L23 (rpl23a and rpl23b).


Pssm-ID: 380957  Cd Length: 252  Bit Score: 100.88  E-value: 2.96e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1111957604  13 LHWVKntddekkiSNHTYISPKIDVKDVRSSGRGIYAVE-PLKKGELILNIPHSFLLNFTTVMAHIVKYNGMAidshihv 91
Cdd:cd19180     1 LEWAT--------ENGAKIHPKLEFRYDPDSGISVVATEnAIDPGETLLSIPTSLILTPENARKSFLGALSLA------- 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1111957604  92 pfdksedeyteiyrtLTKEEILELSsfQLLSLYLTFERKRS-HKSFWKPFLDMLPSMDDfelMPIDW-PQEVCTLLPSST 169
Cdd:cd19180    66 ---------------SAALESLLPR--RLLLVFLLIERRGLgLGSFWGPYIDLLPKEFS---TPLYWsDDELELLRGTNL 125

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1111957604 170 EVRNKKVRSRFDNDYQVICELIKtKIDKDGDVTTLlprQEVLLSWLCINSRCL---YMDLPTSKNSADNFTMAPYVDFMN 246
Cdd:cd19180   126 FGAVQDRREQLEKEYEVLKEALK-SEHPPKEVFTF---EDYLWAYTIVSSRSFpsrLVSDSGDTSSESEPVLLPLLDLLN 201

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1111957604 247 HSCDDHCTLKIDGKGFQVRTTSQYNT--GDQVYLSYGPHSNDFLLCEYGFV 295
Cdd:cd19180   202 HKPGAKVTWNTTDTSSAFELVSGDDLakGEQVFNNYGPKSNEELLLGYGFV 252
SET_SETD6 cd19178
SET domain found in SET domain-containing protein 6 (SETD6) and similar proteins; SETD6 is a ...
 31-297 4.17e-17

SET domain found in SET domain-containing protein 6 (SETD6) and similar proteins; SETD6 is a lysine N-methyltransferase that monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulate NF-kappa-B transcription factor activity. It also monomethylates 'Lys-8' of H2AZ (H2AZK8me1).


Pssm-ID: 380955 [Multi-domain]  Cd Length: 250  Bit Score: 80.43  E-value: 4.17e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1111957604  31 ISPKIDVKDVRS-SGRGIYAVEPLKKGELILNIPHSFLLNFTTvmahivkyngmaidSHIHvpfdksedeytEIYRTLTK 109
Cdd:cd19178     3 LSPKVAISKLGSsAGRGMVATEDIKEGEVLFTVPRSALLSPET--------------SSIA-----------DLLEEEED 57

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1111957604 110 EEILELSSFQLLSLYLTFERKRShKSFWKPFLDMLPsmDDFEL-MPIDWPQEVCTLLPSSTEVRnKKVRSRFDNDYQVIC 188
Cdd:cd19178    58 ASLQSLSGWVPLLLALMYEYTNP-SSRWRPYLSLLP--DFSELhHPMFWDEEEREELLGGTGIA-EAVDRDLKEIDEEYN 133

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1111957604 189 ELIKTKIDKDGDVTTLLPRQEVLLSWLCinsrCLYM----DLPTSKNSADNFT--------MAPYVDFMNHSCDDHCTLK 256
Cdd:cd19178   134 SIVLPFIKKHPELFSPEKHSLELYKRMV----AFVMaysfTEPDEDEDDDDEDedddsppmMVPMADMLNHIANNNARLE 209

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1111957604 257 IDGKGFQVRTTSQYNTGDQVYLSYGPHSNDFLLCEYGFVIP 297
Cdd:cd19178   210 FDPDCLRMIATRDIKKGEEIFNTYGELANWELLHMYGFVEP 250
SET_SETD3 cd19176
SET domain found in SET domain-containing protein 3 (SETD3) and similar proteins; SETD3 (EC 2. ...
 34-295 5.75e-09

SET domain found in SET domain-containing protein 3 (SETD3) and similar proteins; SETD3 (EC 2.1.1.43) is a histone-lysine N-methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3 (H3K4me and H3K36me). It functions as a transcriptional activator that plays an important role in the transcriptional regulation of muscle cell differentiation via interaction with MYOD1.


Pssm-ID: 380953  Cd Length: 251  Bit Score: 56.49  E-value: 5.75e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1111957604  34 KIDVKDVRSSGRGIYAVEPLKKGELILNIPhsfllnfTTVMahivkyngMAIDSHihvpfdksedEYTEIYRTLTKEEIL 113
Cdd:cd19176    16 KVEIAFFEEEGYGLRATRDIKAGELLLSIP-------RKLM--------ITAEAA----------KSSVLGPLIESDPIL 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1111957604 114 ELSSFQLLSLYLTFERkRSHKSFWKPFLDMLPSmdDFELmPIDWPQEVCTLLPSST-------EVRNkKVR--SRFdndY 184
Cdd:cd19176    71 QAMPNVALALHLLCER-SNPNSFWKPYIDILPS--SYTT-PLYFTPEELLLLKGSPafeeainQYRN-IARqyAYF---Y 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1111957604 185 QVICELIKTKIDKDGD----------VTTLLPRQevllswlciNSrclymdLPTSkNSADNFTMA--PYVDFMNHSCDDH 252
Cdd:cd19176   143 QLLQTSPLASKLNLRNsftfddyrwaVSTVMTRQ---------NQ------IPTE-DGTERSTLAliPLWDMCNHANGKI 206

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1111957604 253 CTlKIDGKGFQVRTTSQ--YNTGDQVYLSYGPHSNDFLLCEYGFV 295
Cdd:cd19176   207 TT-DYNLESDSLECVAMedFKAGEQVFIFYGPRSNAELLLHSGFV 250
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 213-281 6.02e-04

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 39.43  E-value: 6.02e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1111957604 213 SWLCINSRCLYMDLPTsknsadnftmapyvDFMNHSCDDHCTLKID----GKGFQVRTTSQYNTGDQVYLSYG 281
Cdd:pfam00856  57 SEYCIDARALYYGNWA--------------RFINHSCDPNCEVRVVyvngGPRIVIFALRDIKPGEELTIDYG 115
SET_SMYD cd20071
SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing ...
 244-294 1.20e-03

SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing protein, and similar proteins; The family includes SET and MYND domain-containing proteins, SMYD1-SYMD5. SMYD1 (EC 2.1.1.43; also termed BOP) is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD2 (also termed HSKM-B, or lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. SMYD5 (also termed protein NN8-4AG, or retinoic acid-induced protein 15) functions as histone lysine methyltransferase that mediates H4K20me3 at heterochromatin regions.


Pssm-ID: 380997 [Multi-domain]  Cd Length: 122  Bit Score: 38.51  E-value: 1.20e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1111957604 244 FMNHSCDDHCTLKIDGKG-FQVRTTSQYNTGDQVYLSYGPHSNDF------LLCEYGF 294
Cdd:cd20071    58 LLNHSCDPNAVVVFDGNGtLRVRALRDIKAGEELTISYIDPLLPRterrreLLEKYGF 115
SET_SMYD1_2_3-like cd19167
SET domain (including post-SET domain) found in SET and MYND domain-containing proteins, SMYD1, ...
 240-280 4.72e-03

SET domain (including post-SET domain) found in SET and MYND domain-containing proteins, SMYD1, SMYD2, SMYD3 and similar proteins; The family includes SET and MYND domain-containing proteins, SMYD1, SMYD2 and SMYD3. SMYD1 (EC 2.1.1.43; also termed BOP) is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD2 (also termed HSKM-B, or lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex.


Pssm-ID: 380944 [Multi-domain]  Cd Length: 205  Bit Score: 38.18  E-value: 4.72e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1111957604 240 PYVDFMNHSCDDHCTLKIDGKGFQVRTTSQYNTGDQVYLSY 280
Cdd:cd19167   136 PQAALLNHSCCPNCIVTFNGPNIEVRAVQEIEPGEEVFHSY 176
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH