NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|111955338|ref|NP_032560|]
View 

T-lymphocyte surface antigen Ly-9 isoform 1 precursor [Mus musculus]

Protein Classification

Ig_SLAM-like_N and Ig_2 domain-containing protein( domain architecture ID 11617254)

Ig_SLAM-like_N and Ig_2 domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Ig_SLAM-like_N cd16842
N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule ...
 53-151 3.22e-35

N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family and similar proteins. The SLAM family is a group of immune-cell specific receptors that can regulate both adaptive and innate immune responses. Members of this group include proteins such as CD84, SLAM (CD150), Ly-9 (CD229), NTB-A (ly-108, SLAM6), 19A (CRACC), and SLAMF9. The genes coding for the SLAM family are nested on chromosome 1, in humans at 1q23, and in mice at 1H2. The SLAM family is a subset of the CD2 family, which also includes CD2 and CD58 located on chromosome 1 at 1p13 in humans. In mice, CD2 is located on chromosome 3, and there is no CD58 homolog. The SLAM family proteins are organized as an extracellular domain with either two or four Ig-like domains, a single transmembrane segment, and a cytoplasmic region having Tyr-based motifs. The extracellular domain is organized as a membrane-distal Ig variable (IgV) domain that is responsible for ligand recognition and a membrane-proximal truncated Ig constant-2 (IgC2) domain.


:

Pssm-ID: 409517  Cd Length: 102  Bit Score: 128.59  E-value: 3.22e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111955338  53 TVISGMLGGSVTFSLNISKDAEIEHIIWNCPPKALALVFYK---KDITILDKGYNGRLKVSEDGYSLYMSNLTKSDSGSY 129
Cdd:cd16842    1 KEVNGILGGSVTFPLNISDGQEIENITWSFKTSLAVIAPGEggaPEIIITDKSYKERLNISQNDYSLQISNLTMEDAGSY 80

                         90       100
                 ....*....|....*....|..
gi 111955338 130 HAQINQKNVILTTNKEFTLHIY 151
Cdd:cd16842   81 RARINTKNSRVTITKEFTLHIY 102
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 254-356 1.02e-22

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd16842:

Pssm-ID: 472250  Cd Length: 102  Bit Score: 93.15  E-value: 1.02e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111955338 254 KTVVGILGEPVTLPLEFRATRATKNVVWVFNTSVISQERrGAATADSRRKPKGSEERRVRTSDQDQSLKISQLKMEDAGP 333
Cdd:cd16842    1 KEVNGILGGSVTFPLNISDGQEIENITWSFKTSLAVIAP-GEGGAPEIIITDKSYKERLNISQNDYSLQISNLTMEDAGS 79

                         90       100
                 ....*....|....*....|...
gi 111955338 334 YHAYVCSEASRDPSVRHFTLLVY 356
Cdd:cd16842   80 YRARINTKNSRVTITKEFTLHIY 102
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 156-239 5.81e-08

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


:

Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 50.47  E-value: 5.81e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111955338  156 KPQIIVESVTPsdTDSCTFTLICTVKGtKDSVQYSWTREDTHLNTYDGSHTLRVSqsVCDPDLpYTCKAWNPVSQNSSQP 235
Cdd:pfam13895   1 KPVLTPSPTVV--TEGEPVTLTCSAPG-NPPPSYTWYKDGSAISSSPNFFTLSVS--AEDSGT-YTCVARNGRGGKVSNP 74


                  ....
gi 111955338  236 VRIW 239
Cdd:pfam13895  75 VELT 78
 
Name Accession Description Interval E-value
Ig_SLAM-like_N cd16842
N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule ...
 53-151 3.22e-35

N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family and similar proteins. The SLAM family is a group of immune-cell specific receptors that can regulate both adaptive and innate immune responses. Members of this group include proteins such as CD84, SLAM (CD150), Ly-9 (CD229), NTB-A (ly-108, SLAM6), 19A (CRACC), and SLAMF9. The genes coding for the SLAM family are nested on chromosome 1, in humans at 1q23, and in mice at 1H2. The SLAM family is a subset of the CD2 family, which also includes CD2 and CD58 located on chromosome 1 at 1p13 in humans. In mice, CD2 is located on chromosome 3, and there is no CD58 homolog. The SLAM family proteins are organized as an extracellular domain with either two or four Ig-like domains, a single transmembrane segment, and a cytoplasmic region having Tyr-based motifs. The extracellular domain is organized as a membrane-distal Ig variable (IgV) domain that is responsible for ligand recognition and a membrane-proximal truncated Ig constant-2 (IgC2) domain.


Pssm-ID: 409517  Cd Length: 102  Bit Score: 128.59  E-value: 3.22e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111955338  53 TVISGMLGGSVTFSLNISKDAEIEHIIWNCPPKALALVFYK---KDITILDKGYNGRLKVSEDGYSLYMSNLTKSDSGSY 129
Cdd:cd16842    1 KEVNGILGGSVTFPLNISDGQEIENITWSFKTSLAVIAPGEggaPEIIITDKSYKERLNISQNDYSLQISNLTMEDAGSY 80

                         90       100
                 ....*....|....*....|..
gi 111955338 130 HAQINQKNVILTTNKEFTLHIY 151
Cdd:cd16842   81 RARINTKNSRVTITKEFTLHIY 102
Ig_SLAM-like_N cd16842
N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule ...
 254-356 1.02e-22

N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family and similar proteins. The SLAM family is a group of immune-cell specific receptors that can regulate both adaptive and innate immune responses. Members of this group include proteins such as CD84, SLAM (CD150), Ly-9 (CD229), NTB-A (ly-108, SLAM6), 19A (CRACC), and SLAMF9. The genes coding for the SLAM family are nested on chromosome 1, in humans at 1q23, and in mice at 1H2. The SLAM family is a subset of the CD2 family, which also includes CD2 and CD58 located on chromosome 1 at 1p13 in humans. In mice, CD2 is located on chromosome 3, and there is no CD58 homolog. The SLAM family proteins are organized as an extracellular domain with either two or four Ig-like domains, a single transmembrane segment, and a cytoplasmic region having Tyr-based motifs. The extracellular domain is organized as a membrane-distal Ig variable (IgV) domain that is responsible for ligand recognition and a membrane-proximal truncated Ig constant-2 (IgC2) domain.


Pssm-ID: 409517  Cd Length: 102  Bit Score: 93.15  E-value: 1.02e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111955338 254 KTVVGILGEPVTLPLEFRATRATKNVVWVFNTSVISQERrGAATADSRRKPKGSEERRVRTSDQDQSLKISQLKMEDAGP 333
Cdd:cd16842    1 KEVNGILGGSVTFPLNISDGQEIENITWSFKTSLAVIAP-GEGGAPEIIITDKSYKERLNISQNDYSLQISNLTMEDAGS 79

                         90       100
                 ....*....|....*....|...
gi 111955338 334 YHAYVCSEASRDPSVRHFTLLVY 356
Cdd:cd16842   80 YRARINTKNSRVTITKEFTLHIY 102
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 156-239 5.81e-08

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 50.47  E-value: 5.81e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111955338  156 KPQIIVESVTPsdTDSCTFTLICTVKGtKDSVQYSWTREDTHLNTYDGSHTLRVSqsVCDPDLpYTCKAWNPVSQNSSQP 235
Cdd:pfam13895   1 KPVLTPSPTVV--TEGEPVTLTCSAPG-NPPPSYTWYKDGSAISSSPNFFTLSVS--AEDSGT-YTCVARNGRGGKVSNP 74


                  ....
gi 111955338  236 VRIW 239
Cdd:pfam13895  75 VELT 78
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 50-151 1.54e-04

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 41.29  E-value: 1.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111955338   50 TPPTVISGMLGGSVTF--SLNISKDAEIEHIIW-----NCPPKALALVFYKKD-ITILDKGYNGRLKVSEDGYSLYMSNL 121
Cdd:pfam07686   1 QTPREVTVALGGSVTLpcTYSSSMSEASTSVYWyrqppGKGPTFLIAYYSNGSeEGVKKGRFSGRGDPSNGDGSLTIQNL 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 111955338  122 TKSDSGSYHAQINQKNvILTTNKEFTLHIY 151
Cdd:pfam07686  81 TLSDSGTYTCAVIPSG-EGVFGKGTRLTVL 109
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 52-129 6.17e-04

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 39.03  E-value: 6.17e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111955338    52 PTVISGMLGGSVTFSLNISKDAEIeHIIWncppkalalvfYKKDITILdkGYNGRLKVSEDG--YSLYMSNLTKSDSGSY 129
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSPPP-EVTW-----------YKQGGKLL--AESGRFSVSRSGstSTLTISNVTPEDSGTY 66
 
Name Accession Description Interval E-value
Ig_SLAM-like_N cd16842
N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule ...
 53-151 3.22e-35

N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family and similar proteins. The SLAM family is a group of immune-cell specific receptors that can regulate both adaptive and innate immune responses. Members of this group include proteins such as CD84, SLAM (CD150), Ly-9 (CD229), NTB-A (ly-108, SLAM6), 19A (CRACC), and SLAMF9. The genes coding for the SLAM family are nested on chromosome 1, in humans at 1q23, and in mice at 1H2. The SLAM family is a subset of the CD2 family, which also includes CD2 and CD58 located on chromosome 1 at 1p13 in humans. In mice, CD2 is located on chromosome 3, and there is no CD58 homolog. The SLAM family proteins are organized as an extracellular domain with either two or four Ig-like domains, a single transmembrane segment, and a cytoplasmic region having Tyr-based motifs. The extracellular domain is organized as a membrane-distal Ig variable (IgV) domain that is responsible for ligand recognition and a membrane-proximal truncated Ig constant-2 (IgC2) domain.


Pssm-ID: 409517  Cd Length: 102  Bit Score: 128.59  E-value: 3.22e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111955338  53 TVISGMLGGSVTFSLNISKDAEIEHIIWNCPPKALALVFYK---KDITILDKGYNGRLKVSEDGYSLYMSNLTKSDSGSY 129
Cdd:cd16842    1 KEVNGILGGSVTFPLNISDGQEIENITWSFKTSLAVIAPGEggaPEIIITDKSYKERLNISQNDYSLQISNLTMEDAGSY 80

                         90       100
                 ....*....|....*....|..
gi 111955338 130 HAQINQKNVILTTNKEFTLHIY 151
Cdd:cd16842   81 RARINTKNSRVTITKEFTLHIY 102
Ig_SLAM-like_N cd16842
N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule ...
 254-356 1.02e-22

N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family and similar proteins. The SLAM family is a group of immune-cell specific receptors that can regulate both adaptive and innate immune responses. Members of this group include proteins such as CD84, SLAM (CD150), Ly-9 (CD229), NTB-A (ly-108, SLAM6), 19A (CRACC), and SLAMF9. The genes coding for the SLAM family are nested on chromosome 1, in humans at 1q23, and in mice at 1H2. The SLAM family is a subset of the CD2 family, which also includes CD2 and CD58 located on chromosome 1 at 1p13 in humans. In mice, CD2 is located on chromosome 3, and there is no CD58 homolog. The SLAM family proteins are organized as an extracellular domain with either two or four Ig-like domains, a single transmembrane segment, and a cytoplasmic region having Tyr-based motifs. The extracellular domain is organized as a membrane-distal Ig variable (IgV) domain that is responsible for ligand recognition and a membrane-proximal truncated Ig constant-2 (IgC2) domain.


Pssm-ID: 409517  Cd Length: 102  Bit Score: 93.15  E-value: 1.02e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111955338 254 KTVVGILGEPVTLPLEFRATRATKNVVWVFNTSVISQERrGAATADSRRKPKGSEERRVRTSDQDQSLKISQLKMEDAGP 333
Cdd:cd16842    1 KEVNGILGGSVTFPLNISDGQEIENITWSFKTSLAVIAP-GEGGAPEIIITDKSYKERLNISQNDYSLQISNLTMEDAGS 79

                         90       100
                 ....*....|....*....|...
gi 111955338 334 YHAYVCSEASRDPSVRHFTLLVY 356
Cdd:cd16842   80 YRARINTKNSRVTITKEFTLHIY 102
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 156-239 5.81e-08

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 50.47  E-value: 5.81e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111955338  156 KPQIIVESVTPsdTDSCTFTLICTVKGtKDSVQYSWTREDTHLNTYDGSHTLRVSqsVCDPDLpYTCKAWNPVSQNSSQP 235
Cdd:pfam13895   1 KPVLTPSPTVV--TEGEPVTLTCSAPG-NPPPSYTWYKDGSAISSSPNFFTLSVS--AEDSGT-YTCVARNGRGGKVSNP 74


                  ....
gi 111955338  236 VRIW 239
Cdd:pfam13895  75 VELT 78
IgV_CD2_like_N cd05775
N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; ...
 55-151 8.35e-05

N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain (or domain 1) of T-cell surface antigen Clusters of Differentiation (CD) 2 and similar proteins. CD2 is a T-cell specific surface glycoprotein and is critically important for mediating adhesion between T cells and antigen-presenting cells or between cytolytic T cells and target cells. CD2 is located on chromosome 1 at 1p13 in humans and on chromosome 3 in mice. CD2 contains an extracellular domain with two or Ig-like domains, a single transmembrane segment, and a cytoplasmic region rich in proline and basic residues.


Pssm-ID: 409431  Cd Length: 98  Bit Score: 41.95  E-value: 8.35e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111955338  55 ISGMLGGSVTfsLNISKD-AEIEHIIWNcPPKALALVFYKKDITILDKGYNGRLKVSEDGYSLYMSNLTKSDSGSYHAQI 133
Cdd:cd05775    5 VYGALGGNVT--LTISSLqDDIDEIKWK-KTKDKIVEWENNIGPTYFGSFKDRVLLDKESGSLTIKNLTKEDSGTYELEI 81

                         90
                 ....*....|....*...
gi 111955338 134 NQKNVIlTTNKEFTLHIY 151
Cdd:cd05775   82 TSTNGK-VLSSKFTLEVL 98
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 50-151 1.54e-04

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 41.29  E-value: 1.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111955338   50 TPPTVISGMLGGSVTF--SLNISKDAEIEHIIW-----NCPPKALALVFYKKD-ITILDKGYNGRLKVSEDGYSLYMSNL 121
Cdd:pfam07686   1 QTPREVTVALGGSVTLpcTYSSSMSEASTSVYWyrqppGKGPTFLIAYYSNGSeEGVKKGRFSGRGDPSNGDGSLTIQNL 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 111955338  122 TKSDSGSYHAQINQKNvILTTNKEFTLHIY 151
Cdd:pfam07686  81 TLSDSGTYTCAVIPSG-EGVFGKGTRLTVL 109
IgV_CD2_like_N cd05775
N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; ...
 254-356 1.62e-04

N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain (or domain 1) of T-cell surface antigen Clusters of Differentiation (CD) 2 and similar proteins. CD2 is a T-cell specific surface glycoprotein and is critically important for mediating adhesion between T cells and antigen-presenting cells or between cytolytic T cells and target cells. CD2 is located on chromosome 1 at 1p13 in humans and on chromosome 3 in mice. CD2 contains an extracellular domain with two or Ig-like domains, a single transmembrane segment, and a cytoplasmic region rich in proline and basic residues.


Pssm-ID: 409431  Cd Length: 98  Bit Score: 41.18  E-value: 1.62e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111955338 254 KTVVGILGEPVTL-PLEFRATRatKNVVWVFNTSVIsqerrgaATADSRRKP--KGSEERRVRTSDQDQSLKISQLKMED 330
Cdd:cd05775    3 GEVYGALGGNVTLtISSLQDDI--DEIKWKKTKDKI-------VEWENNIGPtyFGSFKDRVLLDKESGSLTIKNLTKED 73

                         90       100
                 ....*....|....*....|....*.
gi 111955338 331 AGPYHAYVCSEASRDPSVRhFTLLVY 356
Cdd:cd05775   74 SGTYELEITSTNGKVLSSK-FTLEVL 98
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 156-226 3.01e-04

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 39.86  E-value: 3.01e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 111955338  156 KPQIIVESVTPSDTDSCTFTLICTVKGTkDSVQYSWTREDTHLNT--------YDGSHTLRVSQSVCDPDLPYTCKAWN 226
Cdd:pfam13927   1 KPVITVSPSSVTVREGETVTLTCEATGS-PPPTITWYKNGEPISSgstrsrslSGSNSTLTISNVTRSDAGTYTCVASN 78
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 52-129 6.17e-04

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 39.03  E-value: 6.17e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111955338    52 PTVISGMLGGSVTFSLNISKDAEIeHIIWncppkalalvfYKKDITILdkGYNGRLKVSEDG--YSLYMSNLTKSDSGSY 129
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSPPP-EVTW-----------YKQGGKLL--AESGRFSVSRSGstSTLTISNVTPEDSGTY 66
Ig_LP_like cd05877
Immunoglobulin (Ig)-like domain of human cartilage link protein (LP), and similar domains; The ...
 256-334 4.99e-03

Immunoglobulin (Ig)-like domain of human cartilage link protein (LP), and similar domains; The members here are composed of the immunoglobulin (Ig)-like domain similar to that found in human cartilage link protein (LP; also called hyaluronan and proteoglycan link protein). In cartilage, chondroitin-keratan sulfate proteoglycan (CSPG), aggrecan, forms cartilage link protein stabilized aggregates with hyaluronan (HA). These aggregates contribute to the tissue's load bearing properties. Aggregates having other CSPGs substituting for aggrecan may contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.


Pssm-ID: 409461  Cd Length: 117  Bit Score: 37.30  E-value: 4.99e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111955338 256 VVGILGEPVTLPLEFRATRATKN-----VVWVFNTSVISQERRGAATADSRRKPKGSEERRV---RTSDQDQSLKISQLK 327
Cdd:cd05877    7 VFSHRGGNVTLPCRYHYEPELSAprkirVKWTKLEVDYAKEEDVLVAIGTRHKSYGSYQGRVflrRADDLDASLVITDLR 86


                 ....*..
gi 111955338 328 MEDAGPY 334
Cdd:cd05877   87 LEDYGRY 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH