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Conserved domains on  [gi|1133447891|ref|XP_019848770|]
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PREDICTED: wings apart-like protein homolog isoform X1 [Amphimedon queenslandica]

Protein Classification

WAPL family protein( domain architecture ID 10544815)

wings apart-like (WAPL) family protein that may play a role in sister chromatid cohesion; similar to human wings apart-like protein homolog (WAPL) which is a regulator of sister chromatid cohesion in mitosis that destabilizes cohesin binding to chromatin

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WAPL pfam07814
Wings apart-like protein regulation of heterochromatin; This family contains sequences ...
 643-1016 1.67e-39

Wings apart-like protein regulation of heterochromatin; This family contains sequences expressed in eukaryotic organizms bearing high similarity to the WAPL conserved region of D. melanogaster wings apart-like protein. This protein is involved in the regulation of heterochromatin structure. hWAPL, the human homolog, is found to play a role in the development of cervical carcinogenesis, and is thought to have similar functions to Drosophila wapl protein. Malfunction of the hWAPL pathway is thought to activate an apoptotic pathway that consequently leads to cell death.


:

Pssm-ID: 462278  Cd Length: 344  Bit Score: 150.53  E-value: 1.67e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133447891  643 NVRQAHECLQHGENLRFRDDVIYLLDSMKTEEPLL-VRCLSTLNLAEQCLNVDFMRQMRSLGLVKKSLLLLKDAQTHPA- 720
Cdd:pfam07814    1 NVRSIHELREAGENQRFEDEVEYILDDIEDSNPSSsTRRSSLLELASKCLDPAFRRQFRAHGLVKRLFKALGDATDDISg 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133447891  721 -LKVALVTLSFVMTQSNVEPSEL-DKKCTELLVMALSVKDQFLvspageeeppplegkaateykKITDKSKALLKKCSPL 798
Cdd:pfam07814   81 sLALCAATLMLVLSPDSLVMDLDrWSGLLELLLKLLSVDSDIS---------------------VLAKDRKTNLSKSAQK 139

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133447891  799 LIHAKysDSSNTNETVDISLQPSTLSLGELATECFLSLTSSmntsvsslkedLRTLG-AIDVIANRAIALTRQCTGYLTS 877
Cdd:pfam07814  140 SVREL--REQLLKGKIWDDLGPSKLSPQTLALECLESLVSK-----------LRELGgLIDHISDEVLDCLVELLLSSSE 206

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133447891  878 gqeeegkeeeeREGEEREVDVHFMKLFRQLKLLENILCMSKGNQSYLTMFDGsiFISEISKFLvllgdylisKDLSTRHT 957
Cdd:pfam07814  207 -----------RDSWDDLSPEDLRLLELCLSILESVTVLNEENQAYLLWSLG--LLSSLAKLL---------SSSLRRRD 264

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1133447891  958 CIVTETLLGTLRVFLNITHDNALASYRVGE---QEKIIDSICNFTFKLAQ--SVPVIQQFDILV 1016
Cdd:pfam07814  265 DQLRQLQMLALRLLLNLTNNNPSLCEAFSTpelVHGLVEIALSNFLNLSPeyAPDRESSLDLLI 328
PHA03307 super family cl33723
transcriptional regulator ICP4; Provisional
 105-361 1.00e-08

transcriptional regulator ICP4; Provisional


The actual alignment was detected with superfamily member PHA03307:

Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 60.18  E-value: 1.00e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133447891  105 SSGLHVGQKRGRGRPRKTPKEPLDESKDDDSTANESEP---------TSQKPADRGHSRKTLNESTESEPGPNDE----S 171
Cdd:PHA03307   135 SEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAalplsspeeTARAPSSPPAEPPPSTPPAAASPRPPRRsspiS 214

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133447891  172 TGELTPVVKRGRGRPRKTPKSTNESTPNISITSE-----------PESIGQKPPVKRGRG----RPRKTPKSTNESTPNV 236
Cdd:PHA03307   215 ASASSPAPAPGRSAADDAGASSSDSSSSESSGCGwgpenecplprPAPITLPTRIWEASGwngpSSRPGPASSSSSPRER 294

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133447891  237 SIASEPESIGQKPPVKGGRGRPKKIRKEAMNESTASESELVQESTGTESEPSSQQPPVVKRGRGRPRKTPKPSSAVSTPS 316
Cdd:PHA03307   295 SPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRA 374

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*...
gi 1133447891  317 SQEPVVKRGRGRPRKVRPPNDSIGTV---TPSSTEQRPSTIETGDDEA 361
Cdd:PHA03307   375 PSSPAASAGRPTRRRARAAVAGRARRrdaTGRFPAGRPRPSPLDAGAA 422
 
Name Accession Description Interval E-value
WAPL pfam07814
Wings apart-like protein regulation of heterochromatin; This family contains sequences ...
 643-1016 1.67e-39

Wings apart-like protein regulation of heterochromatin; This family contains sequences expressed in eukaryotic organizms bearing high similarity to the WAPL conserved region of D. melanogaster wings apart-like protein. This protein is involved in the regulation of heterochromatin structure. hWAPL, the human homolog, is found to play a role in the development of cervical carcinogenesis, and is thought to have similar functions to Drosophila wapl protein. Malfunction of the hWAPL pathway is thought to activate an apoptotic pathway that consequently leads to cell death.


Pssm-ID: 462278  Cd Length: 344  Bit Score: 150.53  E-value: 1.67e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133447891  643 NVRQAHECLQHGENLRFRDDVIYLLDSMKTEEPLL-VRCLSTLNLAEQCLNVDFMRQMRSLGLVKKSLLLLKDAQTHPA- 720
Cdd:pfam07814    1 NVRSIHELREAGENQRFEDEVEYILDDIEDSNPSSsTRRSSLLELASKCLDPAFRRQFRAHGLVKRLFKALGDATDDISg 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133447891  721 -LKVALVTLSFVMTQSNVEPSEL-DKKCTELLVMALSVKDQFLvspageeeppplegkaateykKITDKSKALLKKCSPL 798
Cdd:pfam07814   81 sLALCAATLMLVLSPDSLVMDLDrWSGLLELLLKLLSVDSDIS---------------------VLAKDRKTNLSKSAQK 139

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133447891  799 LIHAKysDSSNTNETVDISLQPSTLSLGELATECFLSLTSSmntsvsslkedLRTLG-AIDVIANRAIALTRQCTGYLTS 877
Cdd:pfam07814  140 SVREL--REQLLKGKIWDDLGPSKLSPQTLALECLESLVSK-----------LRELGgLIDHISDEVLDCLVELLLSSSE 206

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133447891  878 gqeeegkeeeeREGEEREVDVHFMKLFRQLKLLENILCMSKGNQSYLTMFDGsiFISEISKFLvllgdylisKDLSTRHT 957
Cdd:pfam07814  207 -----------RDSWDDLSPEDLRLLELCLSILESVTVLNEENQAYLLWSLG--LLSSLAKLL---------SSSLRRRD 264

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1133447891  958 CIVTETLLGTLRVFLNITHDNALASYRVGE---QEKIIDSICNFTFKLAQ--SVPVIQQFDILV 1016
Cdd:pfam07814  265 DQLRQLQMLALRLLLNLTNNNPSLCEAFSTpelVHGLVEIALSNFLNLSPeyAPDRESSLDLLI 328
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 105-361 1.00e-08

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 60.18  E-value: 1.00e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133447891  105 SSGLHVGQKRGRGRPRKTPKEPLDESKDDDSTANESEP---------TSQKPADRGHSRKTLNESTESEPGPNDE----S 171
Cdd:PHA03307   135 SEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAalplsspeeTARAPSSPPAEPPPSTPPAAASPRPPRRsspiS 214

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133447891  172 TGELTPVVKRGRGRPRKTPKSTNESTPNISITSE-----------PESIGQKPPVKRGRG----RPRKTPKSTNESTPNV 236
Cdd:PHA03307   215 ASASSPAPAPGRSAADDAGASSSDSSSSESSGCGwgpenecplprPAPITLPTRIWEASGwngpSSRPGPASSSSSPRER 294

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133447891  237 SIASEPESIGQKPPVKGGRGRPKKIRKEAMNESTASESELVQESTGTESEPSSQQPPVVKRGRGRPRKTPKPSSAVSTPS 316
Cdd:PHA03307   295 SPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRA 374

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*...
gi 1133447891  317 SQEPVVKRGRGRPRKVRPPNDSIGTV---TPSSTEQRPSTIETGDDEA 361
Cdd:PHA03307   375 PSSPAASAGRPTRRRARAAVAGRARRrdaTGRFPAGRPRPSPLDAGAA 422
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 110-353 2.33e-03

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 42.06  E-value: 2.33e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133447891  110 VGQKRGRGRPRKTPKEPLDESKDDDSTANESEPTSQKPADRGHSRKTLNESTESEPGPNDESTGE---LTPVVKRGRGRP 186
Cdd:NF033839   271 VVTKFKKGLTQDTPKEPGNKKPSAPKPGMQPSPQPEKKEVKPEPETPKPEVKPQLEKPKPEVKPQpekPKPEVKPQLETP 350

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133447891  187 RKTPKSTNEsTPNISITSEPEsiGQKPPVKRGRGRPRKTPKSTNEsTPNVSIASEPESigQKPPVKGGRGRPKKIRKEAm 266
Cdd:NF033839   351 KPEVKPQPE-KPKPEVKPQPE--KPKPEVKPQPETPKPEVKPQPE-KPKPEVKPQPEK--PKPEVKPQPEKPKPEVKPQ- 423

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133447891  267 NESTASESELVQESTGTESEPSSQQP-PVVKRGRGRPRKTPKPSsavstPSSQEPVVKRgrgRPRKVRPPNDSigtvtPS 345
Cdd:NF033839   424 PEKPKPEVKPQPEKPKPEVKPQPEKPkPEVKPQPETPKPEVKPQ-----PEKPKPEVKP---QPEKPKPDNSK-----PQ 490


                   ....*...
gi 1133447891  346 STEQRPST 353
Cdd:NF033839   491 ADDKKPST 498
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 150-354 4.04e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 41.68  E-value: 4.04e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133447891  150 RGHSRKTLNESTESEPGPNDESTGELTPVVKRGRGRPRKTPKSTNESTPniSITSEPESIGQKPPVKRGRGRPRKTPKST 229
Cdd:pfam03154   40 RSSGRNSPSAASTSSNDSKAESMKKSSKKIKEEAPSPLKSAKRQREKGA--SDTEEPERATAKKSKTQEISRPNSPSEGE 117

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133447891  230 NESTPNVSI----ASEPESIGQKppvkgGRGRPKKIRKEAMNESTASESELVQESTGTESEPSSQQPPVVKRGRGRPRKT 305
Cdd:pfam03154  118 GESSDGRSVndegSSDPKDIDQD-----NRSTSPSIPSPQDNESDSDSSAQQQILQTQPPVLQAQSGAASPPSPPPPGTT 192

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 1133447891  306 PKPSsavSTPSSQEPVVKrGRGRPRKVRPPNDSIGTVTPSSTEQRPSTI 354
Cdd:pfam03154  193 QAAT---AGPTPSAPSVP-PQGSPATSQPPNQTQSTAAPHTLIQQTPTL 237
PBP1 COG5180
PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification]; ...
 91-352 5.75e-03

PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification];


Pssm-ID: 444064 [Multi-domain]  Cd Length: 548  Bit Score: 40.82  E-value: 5.75e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133447891   91 SPIPVRVTGGTSKTSSGLHVGQKRGRGRPRKTPKEPLDESKDDDstanESEPTSQKPADRGHS-----RKTLNESTESEP 165
Cdd:COG5180    125 APAAAAALPKAKVTREATSASAGVALAAALLQRSDPILAKDPDG----DSASTLPPPAEKLDKvltepRDALKDSPEKLD 200

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133447891  166 GPNDESTGELTPVVKRGRGRPRkTPKSTNESTPNISITSEPESIGQKPPVkrgRGRPRKTPKSTNESTPNVSIASEPESI 245
Cdd:COG5180    201 RPKVEVKDEAQEEPPDLTGGAD-HPRPEAASSPKVDPPSTSEARSRPATV---DAQPEMRPPADAKERRRAAIGDTPAAE 276

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133447891  246 GQKPPVKGGRGRPKKIRKEAMNESTASESELVQESTGTesepssqqPPVVKRGRGRPRKTPKPSSAVSTPSSQEPVVKRG 325
Cdd:COG5180    277 PPGLPVLEAGSEPQSDAPEAETARPIDVKGVASAPPAT--------RPVRPPGGARDPGTPRPGQPTERPAGVPEAASDA 348

                          250       260
                   ....*....|....*....|....*..
gi 1133447891  326 RGRPRKVRPPNDSIGTVTPSSTEQRPS 352
Cdd:COG5180    349 GQPPSAYPPAEEAVPGKPLEQGAPRPG 375
 
Name Accession Description Interval E-value
WAPL pfam07814
Wings apart-like protein regulation of heterochromatin; This family contains sequences ...
 643-1016 1.67e-39

Wings apart-like protein regulation of heterochromatin; This family contains sequences expressed in eukaryotic organizms bearing high similarity to the WAPL conserved region of D. melanogaster wings apart-like protein. This protein is involved in the regulation of heterochromatin structure. hWAPL, the human homolog, is found to play a role in the development of cervical carcinogenesis, and is thought to have similar functions to Drosophila wapl protein. Malfunction of the hWAPL pathway is thought to activate an apoptotic pathway that consequently leads to cell death.


Pssm-ID: 462278  Cd Length: 344  Bit Score: 150.53  E-value: 1.67e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133447891  643 NVRQAHECLQHGENLRFRDDVIYLLDSMKTEEPLL-VRCLSTLNLAEQCLNVDFMRQMRSLGLVKKSLLLLKDAQTHPA- 720
Cdd:pfam07814    1 NVRSIHELREAGENQRFEDEVEYILDDIEDSNPSSsTRRSSLLELASKCLDPAFRRQFRAHGLVKRLFKALGDATDDISg 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133447891  721 -LKVALVTLSFVMTQSNVEPSEL-DKKCTELLVMALSVKDQFLvspageeeppplegkaateykKITDKSKALLKKCSPL 798
Cdd:pfam07814   81 sLALCAATLMLVLSPDSLVMDLDrWSGLLELLLKLLSVDSDIS---------------------VLAKDRKTNLSKSAQK 139

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133447891  799 LIHAKysDSSNTNETVDISLQPSTLSLGELATECFLSLTSSmntsvsslkedLRTLG-AIDVIANRAIALTRQCTGYLTS 877
Cdd:pfam07814  140 SVREL--REQLLKGKIWDDLGPSKLSPQTLALECLESLVSK-----------LRELGgLIDHISDEVLDCLVELLLSSSE 206

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133447891  878 gqeeegkeeeeREGEEREVDVHFMKLFRQLKLLENILCMSKGNQSYLTMFDGsiFISEISKFLvllgdylisKDLSTRHT 957
Cdd:pfam07814  207 -----------RDSWDDLSPEDLRLLELCLSILESVTVLNEENQAYLLWSLG--LLSSLAKLL---------SSSLRRRD 264

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1133447891  958 CIVTETLLGTLRVFLNITHDNALASYRVGE---QEKIIDSICNFTFKLAQ--SVPVIQQFDILV 1016
Cdd:pfam07814  265 DQLRQLQMLALRLLLNLTNNNPSLCEAFSTpelVHGLVEIALSNFLNLSPeyAPDRESSLDLLI 328
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 105-361 1.00e-08

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 60.18  E-value: 1.00e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133447891  105 SSGLHVGQKRGRGRPRKTPKEPLDESKDDDSTANESEP---------TSQKPADRGHSRKTLNESTESEPGPNDE----S 171
Cdd:PHA03307   135 SEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAalplsspeeTARAPSSPPAEPPPSTPPAAASPRPPRRsspiS 214

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133447891  172 TGELTPVVKRGRGRPRKTPKSTNESTPNISITSE-----------PESIGQKPPVKRGRG----RPRKTPKSTNESTPNV 236
Cdd:PHA03307   215 ASASSPAPAPGRSAADDAGASSSDSSSSESSGCGwgpenecplprPAPITLPTRIWEASGwngpSSRPGPASSSSSPRER 294

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133447891  237 SIASEPESIGQKPPVKGGRGRPKKIRKEAMNESTASESELVQESTGTESEPSSQQPPVVKRGRGRPRKTPKPSSAVSTPS 316
Cdd:PHA03307   295 SPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRA 374

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*...
gi 1133447891  317 SQEPVVKRGRGRPRKVRPPNDSIGTV---TPSSTEQRPSTIETGDDEA 361
Cdd:PHA03307   375 PSSPAASAGRPTRRRARAAVAGRARRrdaTGRFPAGRPRPSPLDAGAA 422
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 106-381 2.66e-05

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 48.53  E-value: 2.66e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133447891  106 SGLHVGQKRGRGRPRKTPKEPLDESkdddSTANESEPT--SQKPADRGHSRKTLNESTESEPGPNDESTGELTPVV-KRG 182
Cdd:PTZ00449   504 SDKHDEPPEGPEASGLPPKAPGDKE----GEEGEHEDSkeSDEPKEGGKPGETKEGEVGKKPGPAKEHKPSKIPTLsKKP 579

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133447891  183 RG--------RPRKTPKSTNESTPNISITSE----PES--IGQKPPVKRGRGRPRKTPKSTNESTPN-----VSIASEPE 243
Cdd:PTZ00449   580 EFpkdpkhpkDPEEPKKPKRPRSAQRPTRPKspklPELldIPKSPKRPESPKSPKRPPPPQRPSSPErpegpKIIKSPKP 659

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133447891  244 SIGQKPPV--------------KGGRGRPKKIRKEAMNESTASESELVQESTGTESEPSSQQPPVVKRGRGRPRKTPKPS 309
Cdd:PTZ00449   660 PKSPKPPFdpkfkekfyddyldAAAKSKETKTTVVLDESFESILKETLPETPGTPFTTPRPLPPKLPRDEEFPFEPIGDP 739

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1133447891  310 SAVSTPSSQ---EPVVKRGRgrpRKVRPPNDSIGTVTPSSTEQRPSTIETGDDEACLKRDATgvgeDMEEEPVPT 381
Cdd:PTZ00449   740 DAEQPDDIEfftPPEEERTF---FHETPADTPLPDILAEEFKEEDIHAETGEPDEAMKRPDS----PSEHEDKPP 807
PHA03379 PHA03379
EBNA-3A; Provisional
 149-334 1.46e-04

EBNA-3A; Provisional


Pssm-ID: 223066 [Multi-domain]  Cd Length: 935  Bit Score: 46.20  E-value: 1.46e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133447891  149 DRGHSRKTLNESTESEPGPNDEstgELTPVVKRGRGRPRKTP---------------KSTNESTPNISITSEPESIGQKP 213
Cdd:PHA03379   342 DEGATGETREESEDTESDGDDE---ELPRIVSREGTKRKRPPiflrrlhrlllmragKLTERAREALEKASEPTYGTPRP 418

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133447891  214 PVKRgrgrPRKTPKSTNESTPNVSIASEPESigqkPPVKGGRGRPkkirkeaMNESTASESELVQESTGT---ESEPSSQ 290
Cdd:PHA03379   419 PVEK----PRPEVPQSLETATSHGSAQVPEP----PPVHDLEPGP-------LHDQHSMAPCPVAQLPPGplqDLEPGDQ 483

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....
gi 1133447891  291 QPPVVKRGRGRPRKTPKPSSAVSTPSSQEPVVKRGRGrPRKVRP 334
Cdd:PHA03379   484 LPGVVQDGRPACAPVPAPAGPIVRPWEASLSQVPGVA-FAPVMP 526
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 32-316 4.95e-04

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 44.68  E-value: 4.95e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133447891   32 ISPSRTIYRPLPP--SKFKVPSSSVSLKRGTKKKKTSKLDVFD--FHSDDSDYEFDMPIVDYHSPIPVRVTGGTSKTSsg 107
Cdd:PTZ00449   654 IKSPKPPKSPKPPfdPKFKEKFYDDYLDAAAKSKETKTTVVLDesFESILKETLPETPGTPFTTPRPLPPKLPRDEEF-- 731

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133447891  108 lhvgqkrgrgrPRKTPKEPLDESKDDdsTANESEPTSQkpadrghsRKTLNESTESEPGPNDESTGELTPVVKRGRGRPR 187
Cdd:PTZ00449   732 -----------PFEPIGDPDAEQPDD--IEFFTPPEEE--------RTFFHETPADTPLPDILAEEFKEEDIHAETGEPD 790

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133447891  188 KTPKStnestPNISITSEPESIGQKPPVKRGRGRPRKTPKSTNEstpnvsIASEPESIGQKPPvkggrGRPKKIRK---- 263
Cdd:PTZ00449   791 EAMKR-----PDSPSEHEDKPPGDHPSLPKKRHRLDGLALSTTD------LESDAGRIAKDAS-----GKIVKLKRsksf 854

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1133447891  264 ------EAMNESTASESELVQESTGTESEPSSQQPPVVKR----GRGRPRKTPKPSSAVSTPS 316
Cdd:PTZ00449   855 ddlttvEEAEEMGAEARKIVVDDDGTEADDEDTHPPEEKHksevRRRRPPKKPSKPKKPSKPK 917
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
 36-291 8.01e-04

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 43.88  E-value: 8.01e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133447891   36 RTIYRPLPPSKFKVPSS-SVSLKRGTKKKKTSKldvfdfhsddsdyefdmpiVDYHSPIPVRVTGGTSKTSSGLHVGQKR 114
Cdd:PTZ00108  1153 AKEQRLKSKTKGKASKLrKPKLKKKEKKKKKSS-------------------ADKSKKASVVGNSKRVDSDEKRKLDDKP 1213

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133447891  115 GRGRPRKTPKEPLDESKDDDSTANESEPTSQKPADRGHSRKTLNESTESEPGPNDESTGELTPVVkrgRGRPRKTPKSTN 194
Cdd:PTZ00108  1214 DNKKSNSSGSDQEDDEEQKTKPKKSSVKRLKSKKNNSSKSSEDNDEFSSDDLSKEGKPKNAPKRV---SAVQYSPPPPSK 1290

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133447891  195 ESTPNISITSEPESIGQKPPVKRGRGRPRKTPKSTNESTPNVSIASEPESIGQKPPVKGGRGRPkKIRKEAMNESTASES 274
Cdd:PTZ00108  1291 RPDGESNGGSKPSSPTKKKVKKRLEGSLAALKKKKKSEKKTARKKKSKTRVKQASASQSSRLLR-RPRKKKSDSSSEDDD 1369

                          250
                   ....*....|....*..
gi 1133447891  275 ELVQESTGTESEPSSQQ 291
Cdd:PTZ00108  1370 DSEVDDSEDEDDEDDED 1386
PHA03379 PHA03379
EBNA-3A; Provisional
 90-321 1.56e-03

EBNA-3A; Provisional


Pssm-ID: 223066 [Multi-domain]  Cd Length: 935  Bit Score: 42.74  E-value: 1.56e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133447891   90 HSPIPVRVTGGTSKTSSGLHVGQKRGRGRPRKTPKEPLDESKDDDSTANESEPTS--QKPADRGHSRKTLNESTESEPGP 167
Cdd:PHA03379   387 HRLLLMRAGKLTERAREALEKASEPTYGTPRPPVEKPRPEVPQSLETATSHGSAQvpEPPPVHDLEPGPLHDQHSMAPCP 466

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133447891  168 ---------NDESTGELTP-VVKRGRGRPRKTPKSTNestpNISITSEPeSIGQKPPVKRGRGRPRKTPkstNESTPNVS 237
Cdd:PHA03379   467 vaqlppgplQDLEPGDQLPgVVQDGRPACAPVPAPAG----PIVRPWEA-SLSQVPGVAFAPVMPQPMP---VEPVPVPT 538

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133447891  238 IASEpESIGQKPP--VKGGRGRPKKIRKEAMNESTASeselvqeSTGTESEPSSQQPPVVKRGRGRPRKTPKPSSAVSTP 315
Cdd:PHA03379   539 VALE-RPVCPAPPliAMQGPGETSGIVRVRERWRPAP-------WTPNPPRSPSQMSVRDRLARLRAEAQPYQASVEVQP 610

                          250
                   ....*....|..
gi 1133447891  316 ------SSQEPV 321
Cdd:PHA03379   611 pqltqvSPQQPM 622
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 110-353 2.33e-03

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 42.06  E-value: 2.33e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133447891  110 VGQKRGRGRPRKTPKEPLDESKDDDSTANESEPTSQKPADRGHSRKTLNESTESEPGPNDESTGE---LTPVVKRGRGRP 186
Cdd:NF033839   271 VVTKFKKGLTQDTPKEPGNKKPSAPKPGMQPSPQPEKKEVKPEPETPKPEVKPQLEKPKPEVKPQpekPKPEVKPQLETP 350

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133447891  187 RKTPKSTNEsTPNISITSEPEsiGQKPPVKRGRGRPRKTPKSTNEsTPNVSIASEPESigQKPPVKGGRGRPKKIRKEAm 266
Cdd:NF033839   351 KPEVKPQPE-KPKPEVKPQPE--KPKPEVKPQPETPKPEVKPQPE-KPKPEVKPQPEK--PKPEVKPQPEKPKPEVKPQ- 423

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133447891  267 NESTASESELVQESTGTESEPSSQQP-PVVKRGRGRPRKTPKPSsavstPSSQEPVVKRgrgRPRKVRPPNDSigtvtPS 345
Cdd:NF033839   424 PEKPKPEVKPQPEKPKPEVKPQPEKPkPEVKPQPETPKPEVKPQ-----PEKPKPEVKP---QPEKPKPDNSK-----PQ 490


                   ....*...
gi 1133447891  346 STEQRPST 353
Cdd:NF033839   491 ADDKKPST 498
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 150-354 4.04e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 41.68  E-value: 4.04e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133447891  150 RGHSRKTLNESTESEPGPNDESTGELTPVVKRGRGRPRKTPKSTNESTPniSITSEPESIGQKPPVKRGRGRPRKTPKST 229
Cdd:pfam03154   40 RSSGRNSPSAASTSSNDSKAESMKKSSKKIKEEAPSPLKSAKRQREKGA--SDTEEPERATAKKSKTQEISRPNSPSEGE 117

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133447891  230 NESTPNVSI----ASEPESIGQKppvkgGRGRPKKIRKEAMNESTASESELVQESTGTESEPSSQQPPVVKRGRGRPRKT 305
Cdd:pfam03154  118 GESSDGRSVndegSSDPKDIDQD-----NRSTSPSIPSPQDNESDSDSSAQQQILQTQPPVLQAQSGAASPPSPPPPGTT 192

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 1133447891  306 PKPSsavSTPSSQEPVVKrGRGRPRKVRPPNDSIGTVTPSSTEQRPSTI 354
Cdd:pfam03154  193 QAAT---AGPTPSAPSVP-PQGSPATSQPPNQTQSTAAPHTLIQQTPTL 237
PBP1 COG5180
PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification]; ...
 91-352 5.75e-03

PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification];


Pssm-ID: 444064 [Multi-domain]  Cd Length: 548  Bit Score: 40.82  E-value: 5.75e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133447891   91 SPIPVRVTGGTSKTSSGLHVGQKRGRGRPRKTPKEPLDESKDDDstanESEPTSQKPADRGHS-----RKTLNESTESEP 165
Cdd:COG5180    125 APAAAAALPKAKVTREATSASAGVALAAALLQRSDPILAKDPDG----DSASTLPPPAEKLDKvltepRDALKDSPEKLD 200

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133447891  166 GPNDESTGELTPVVKRGRGRPRkTPKSTNESTPNISITSEPESIGQKPPVkrgRGRPRKTPKSTNESTPNVSIASEPESI 245
Cdd:COG5180    201 RPKVEVKDEAQEEPPDLTGGAD-HPRPEAASSPKVDPPSTSEARSRPATV---DAQPEMRPPADAKERRRAAIGDTPAAE 276

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133447891  246 GQKPPVKGGRGRPKKIRKEAMNESTASESELVQESTGTesepssqqPPVVKRGRGRPRKTPKPSSAVSTPSSQEPVVKRG 325
Cdd:COG5180    277 PPGLPVLEAGSEPQSDAPEAETARPIDVKGVASAPPAT--------RPVRPPGGARDPGTPRPGQPTERPAGVPEAASDA 348

                          250       260
                   ....*....|....*....|....*..
gi 1133447891  326 RGRPRKVRPPNDSIGTVTPSSTEQRPS 352
Cdd:COG5180    349 GQPPSAYPPAEEAVPGKPLEQGAPRPG 375
PHA03378 PHA03378
EBNA-3B; Provisional
 139-335 6.49e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 40.82  E-value: 6.49e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133447891  139 ESEPTSQKP--ADRGHSRKTLNESTESEPgPNDESTGELTPVVKRGRGRPRKTPKSTNESTPNISITSEPESIGQKPPVK 216
Cdd:PHA03378   708 AAPPGRAQRpaAATGRARPPAAAPGRARP-PAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGAPTPQPPPQAPPAP 786

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133447891  217 RGRGRPRKTPKSTNESTPNVSIASEPESIGQKPPVK--------GG--RGRPkKIRKEAMNESTASESELVQESTGTESE 286
Cdd:PHA03378   787 QQRPRGAPTPQPPPQAGPTSMQLMPRAAPGQQGPTKqilrqlltGGvkRGRP-SLKKPAALERQAAAGPTPSPGSGTSDK 865

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1133447891  287 --------PSSQQPPVVKRGRGRPRktPKPSSAVSTPSSQEPVVKRGRGR--PRKVRPP 335
Cdd:PHA03378   866 ivqapvfyPPVLQPIQVMRQLGSVR--AAAASTVTQAPTEYTGERRGVGPmhPTDIPPS 922
PHA03247 PHA03247
large tegument protein UL36; Provisional
 186-420 6.85e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.08  E-value: 6.85e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133447891  186 PRKTPKSTNESTPnisiTSEPESIGQKPPVKRGRGRPRKTPKSTNESTPN----------VSIASEPESIGQKPPVKGGR 255
Cdd:PHA03247  2557 PAAPPAAPDRSVP----PPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVddrgdprgpaPPSPLPPDTHAPDPPPPSPS 2632

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133447891  256 GRPkkirkeamNESTASESELVQESTGTESEPSsqqPPVVKRGRgRPRKTPKPSSAVSTPSsqepvvkrgRGRPRKVRPP 335
Cdd:PHA03247  2633 PAA--------NEPDPHPPPTVPPPERPRDDPA---PGRVSRPR-RARRLGRAAQASSPPQ---------RPRRRAARPT 2691

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133447891  336 ndsIGTVT--------PSSTEQRPSTIETGDDEACLKRDATGVGEDMEEEPVPtildiidkeekSTPANNPSTKAQDTME 407
Cdd:PHA03247  2692 ---VGSLTsladppppPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAP-----------PAVPAGPATPGGPARP 2757

                          250
                   ....*....|...
gi 1133447891  408 TTTIVITVPPDPT 420
Cdd:PHA03247  2758 ARPPTTAGPPAPA 2770
PLN02967 PLN02967
kinase
 154-285 7.30e-03

kinase


Pssm-ID: 215521 [Multi-domain]  Cd Length: 581  Bit Score: 40.41  E-value: 7.30e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133447891  154 RKTLNESTESEPGPNDESTGEL--TPVVKRGRGRPRKTPKSTNESTPNISITSEPESIGQKPPVKRgRGRPRKtpKSTNE 231
Cdd:PLN02967    48 SRKKIESALAVDEEPDENGAVSkkKPTRSVKRATKKTVVEISEPLEEGSELVVNEDAALDKESKKT-PRRTRR--KAAAA 124

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1133447891  232 STPNVSIASEPESigqkppvkggRGRPKKIRKEAMNESTASESEL--VQESTGTES 285
Cdd:PLN02967   125 SSDVEEEKTEKKV----------RKRRKVKKMDEDVEDQGSESEVsdVEESEFVTS 170
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 147-380 7.60e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 40.54  E-value: 7.60e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133447891  147 PADRGHSRKTLNESTESEPGPNDESTGELTPVVKRGRGRPRKTPKST---NESTPNISITSEPESIGQKPPvkrgrgrpr 223
Cdd:PHA03307    61 ACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTppgPSSPDPPPPTPPPASPPPSPA--------- 131

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133447891  224 ktpkstNESTPNVSIASEPESIGQKPPVKGGRGRPKKIRKEAMNESTASESELVQESTGTESEPSSqqPPVVKRGRGRPR 303
Cdd:PHA03307   132 ------PDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPA--EPPPSTPPAAAS 203

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1133447891  304 KTPKPSSAVSTPSSQEPVVKRGRGRPRKVRPPNDSigtvtpSSTEQRPSTIETGDDEACLKRDATGVGEDMEEEPVP 380
Cdd:PHA03307   204 PRPPRRSSPISASASSPAPAPGRSAADDAGASSSD------SSSSESSGCGWGPENECPLPRPAPITLPTRIWEASG 274
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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