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Conserved domains on  [gi|114596764|ref|XP_526724|]
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annexin A10 [Pan troglodytes]

Protein Classification

annexin( domain architecture ID 10446041)

annexin belongs to a family of calcium- and phospholipid-binding proteins that have been implicated in many cellular processes, including channel formation, membrane fusion, vesicle transport, and regulation of phospholipase A2 activity

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
93-158 3.09e-24

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 93.31  E-value: 3.09e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 114596764   93 YDAHELWHAMKGVGTDENCLIEILASRTNGEIFQMREAYCLQYSNNLQEDIYSETSGHFRDTLMNL 158
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
251-316 8.29e-22

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 86.76  E-value: 8.29e-22
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 114596764  251 YFAYRLYSAIHDFGFHNKTVIRILIARSEIDLLTIRKRYKERYGKSLFHDIRNFASGHYKKALLAI 316
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
22-86 1.45e-19

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 80.98  E-value: 1.45e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 114596764   22 DAQMLGGALQGFDCDKDMLINILTQRCNAQRMMIAEAYQSMYGRDLIGDLREQLSDHFKDVMVGL 86
Cdd:pfam00191   2 DAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
175-241 1.16e-16

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 72.89  E-value: 1.16e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 114596764  175 QDAMVLWEACQqKTGEHKTMLQMILCNKSYQQLWLVFQEFQNISGQDMVDAINECYDGYFQELLVAI 241
Cdd:pfam00191   1 YDAELLRKAMK-GLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
 
Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
93-158 3.09e-24

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 93.31  E-value: 3.09e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 114596764   93 YDAHELWHAMKGVGTDENCLIEILASRTNGEIFQMREAYCLQYSNNLQEDIYSETSGHFRDTLMNL 158
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
251-316 8.29e-22

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 86.76  E-value: 8.29e-22
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 114596764  251 YFAYRLYSAIHDFGFHNKTVIRILIARSEIDLLTIRKRYKERYGKSLFHDIRNFASGHYKKALLAI 316
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
22-86 1.45e-19

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 80.98  E-value: 1.45e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 114596764   22 DAQMLGGALQGFDCDKDMLINILTQRCNAQRMMIAEAYQSMYGRDLIGDLREQLSDHFKDVMVGL 86
Cdd:pfam00191   2 DAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
175-241 1.16e-16

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 72.89  E-value: 1.16e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 114596764  175 QDAMVLWEACQqKTGEHKTMLQMILCNKSYQQLWLVFQEFQNISGQDMVDAINECYDGYFQELLVAI 241
Cdd:pfam00191   1 YDAELLRKAMK-GLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
268-316 4.87e-15

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 68.20  E-value: 4.87e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 114596764   268 KTVIRILIARSEIDLLTIRKRYKERYGKSLFHDIRNFASGHYKKALLAI 316
Cdd:smart00335   5 KTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
106-158 2.39e-14

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 66.28  E-value: 2.39e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 114596764   106 GTDENCLIEILASRTNGEIFQMREAYCLQYSNNLQEDIYSETSGHFRDTLMNL 158
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
36-86 3.03e-13

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 63.20  E-value: 3.03e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 114596764    36 DKDMLINILTQRCNAQRMMIAEAYQSMYGRDLIGDLREQLSDHFKDVMVGL 86
Cdd:smart00335   3 DEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
198-241 5.10e-05

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 40.08  E-value: 5.10e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 114596764   198 ILCNKSYQQLWLVFQEFQNISGQDMVDAINECYDGYFQELLVAI 241
Cdd:smart00335  10 ILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
 
Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
93-158 3.09e-24

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 93.31  E-value: 3.09e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 114596764   93 YDAHELWHAMKGVGTDENCLIEILASRTNGEIFQMREAYCLQYSNNLQEDIYSETSGHFRDTLMNL 158
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
251-316 8.29e-22

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 86.76  E-value: 8.29e-22
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 114596764  251 YFAYRLYSAIHDFGFHNKTVIRILIARSEIDLLTIRKRYKERYGKSLFHDIRNFASGHYKKALLAI 316
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
22-86 1.45e-19

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 80.98  E-value: 1.45e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 114596764   22 DAQMLGGALQGFDCDKDMLINILTQRCNAQRMMIAEAYQSMYGRDLIGDLREQLSDHFKDVMVGL 86
Cdd:pfam00191   2 DAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
175-241 1.16e-16

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 72.89  E-value: 1.16e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 114596764  175 QDAMVLWEACQqKTGEHKTMLQMILCNKSYQQLWLVFQEFQNISGQDMVDAINECYDGYFQELLVAI 241
Cdd:pfam00191   1 YDAELLRKAMK-GLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
268-316 4.87e-15

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 68.20  E-value: 4.87e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 114596764   268 KTVIRILIARSEIDLLTIRKRYKERYGKSLFHDIRNFASGHYKKALLAI 316
Cdd:smart00335   5 KTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
106-158 2.39e-14

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 66.28  E-value: 2.39e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 114596764   106 GTDENCLIEILASRTNGEIFQMREAYCLQYSNNLQEDIYSETSGHFRDTLMNL 158
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
36-86 3.03e-13

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 63.20  E-value: 3.03e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 114596764    36 DKDMLINILTQRCNAQRMMIAEAYQSMYGRDLIGDLREQLSDHFKDVMVGL 86
Cdd:smart00335   3 DEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
198-241 5.10e-05

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 40.08  E-value: 5.10e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 114596764   198 ILCNKSYQQLWLVFQEFQNISGQDMVDAINECYDGYFQELLVAI 241
Cdd:smart00335  10 ILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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