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Conserved domains on  [gi|1158966714|dbj|BAX01865|]
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small T antigen [Miniopterus schreibersii polyomavirus 1]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA03102 super family cl42983
Small T antigen; Reviewed
 7-152 1.59e-35

Small T antigen; Reviewed


The actual alignment was detected with superfamily member PHA03102:

Pssm-ID: 222986 [Multi-domain]  Cd Length: 153  Bit Score: 121.32  E-value: 1.59e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1158966714   7 KKEREQLVELLEVHPQAFYNVPIMKTAFKKACKKWHPDKGGDTTKMTLLNSLWQRYQQGVIGLRS----SQVRPGQLDIW 82
Cdd:PHA03102    1 REESKELMDLLGLPRSAWGNLPLMRKAYLRKCLEFHPDKGGDEEKMKELNTLYKKFRESVKSLRDldgeEDSSSEEEDVP 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1158966714  83 DVCLEQTFSIPQLRDLMLKSPQCLVMAKSCCTCIASTLINQHLYiKKREGKKCLVWGECFCIFCFALWFG 152
Cdd:PHA03102   81 SGYVGATFGDRVNALYCKDWDTCLKNLSSLCKCIFCLLRKQHRL-KQKLRPEPLVWGECYCYKCFRQWFG 149
 
Name Accession Description Interval E-value
PHA03102 PHA03102
Small T antigen; Reviewed
 7-152 1.59e-35

Small T antigen; Reviewed


Pssm-ID: 222986 [Multi-domain]  Cd Length: 153  Bit Score: 121.32  E-value: 1.59e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1158966714   7 KKEREQLVELLEVHPQAFYNVPIMKTAFKKACKKWHPDKGGDTTKMTLLNSLWQRYQQGVIGLRS----SQVRPGQLDIW 82
Cdd:PHA03102    1 REESKELMDLLGLPRSAWGNLPLMRKAYLRKCLEFHPDKGGDEEKMKELNTLYKKFRESVKSLRDldgeEDSSSEEEDVP 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1158966714  83 DVCLEQTFSIPQLRDLMLKSPQCLVMAKSCCTCIASTLINQHLYiKKREGKKCLVWGECFCIFCFALWFG 152
Cdd:PHA03102   81 SGYVGATFGDRVNALYCKDWDTCLKNLSSLCKCIFCLLRKQHRL-KQKLRPEPLVWGECYCYKCFRQWFG 149
Papo_T_antigen pfam02380
T-antigen specific domain; This domain represents a conserved region in papovavirus small and ...
 103-173 3.17e-16

T-antigen specific domain; This domain represents a conserved region in papovavirus small and middle T-antigens. It is found as the N-terminal domain in the small T-antigen, and is centrally located in the middle T-antigen.


Pssm-ID: 367062  Cd Length: 93  Bit Score: 70.11  E-value: 3.17e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1158966714 103 PQCLVMAKSCCTCIASTLINQHLYIKKREGKKCLVWGECFCIFCFALWFGAAHTWETFELWAKIIAQLPKC 173
Cdd:pfam02380  19 PTCLKNVSSNCNCILCLLRKQHKNRKKFLRKPPLVWGECYCYDCYRQWFGLPLTEETLFLWAQIIANTPFR 89
DnaJ smart00271
DnaJ molecular chaperone homology domain;
15-60 7.98e-07

DnaJ molecular chaperone homology domain;


Pssm-ID: 197617 [Multi-domain]  Cd Length: 60  Bit Score: 44.53  E-value: 7.98e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1158966714   15 ELLEVHPQAfyNVPIMKTAFKKACKKWHPDKGGDTT-----KMTLLNSLWQ 60
Cdd:smart00271   5 EILGVPRDA--SLDEIKKAYRKLALKYHPDKNPGDKeeaeeKFKEINEAYE 53
DnaJ cd06257
DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and ...
 15-60 1.14e-03

DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, an important chaperonine family. Hsp40 proteins are characterized by the presence of a J domain, which mediates the interaction with Hsp70. They may contain other domains as well, and the architectures provide a means of classification.


Pssm-ID: 99751 [Multi-domain]  Cd Length: 55  Bit Score: 35.60  E-value: 1.14e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1158966714  15 ELLEVHPQAfyNVPIMKTAFKKACKKWHPDKGGD----TTKMTLLNSLWQ 60
Cdd:cd06257     4 DILGVPPDA--SDEEIKKAYRKLALKYHPDKNPDdpeaEEKFKEINEAYE 51
CbpA COG2214
Curved DNA-binding protein CbpA, contains a DnaJ-like domain [Transcription];
15-48 1.29e-03

Curved DNA-binding protein CbpA, contains a DnaJ-like domain [Transcription];


Pssm-ID: 441816 [Multi-domain]  Cd Length: 91  Bit Score: 36.62  E-value: 1.29e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1158966714  15 ELLEVHPQAfyNVPIMKTAFKKACKKWHPDKGGD 48
Cdd:COG2214     9 AVLGVPPDA--SLEEIRQAYRRLAKLLHPDRGGE 40
 
Name Accession Description Interval E-value
PHA03102 PHA03102
Small T antigen; Reviewed
 7-152 1.59e-35

Small T antigen; Reviewed


Pssm-ID: 222986 [Multi-domain]  Cd Length: 153  Bit Score: 121.32  E-value: 1.59e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1158966714   7 KKEREQLVELLEVHPQAFYNVPIMKTAFKKACKKWHPDKGGDTTKMTLLNSLWQRYQQGVIGLRS----SQVRPGQLDIW 82
Cdd:PHA03102    1 REESKELMDLLGLPRSAWGNLPLMRKAYLRKCLEFHPDKGGDEEKMKELNTLYKKFRESVKSLRDldgeEDSSSEEEDVP 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1158966714  83 DVCLEQTFSIPQLRDLMLKSPQCLVMAKSCCTCIASTLINQHLYiKKREGKKCLVWGECFCIFCFALWFG 152
Cdd:PHA03102   81 SGYVGATFGDRVNALYCKDWDTCLKNLSSLCKCIFCLLRKQHRL-KQKLRPEPLVWGECYCYKCFRQWFG 149
PHA02624 PHA02624
large T antigen; Provisional
 1-72 1.32e-21

large T antigen; Provisional


Pssm-ID: 222912 [Multi-domain]  Cd Length: 647  Bit Score: 90.81  E-value: 1.32e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1158966714   1 MDRLLEKKEREQLVELLEVHPQAFYNVPIMKTAFKKACKKWHPDKGGDTTKMTLLNSLWQRYQQGVIGLRSS 72
Cdd:PHA02624    1 MDKTLSREESKELMDLLGLPMAAWGNLPLMRKAYLRKCKEYHPDKGGDEEKMKRLNSLYKKLQEGVKSARQS 72
Papo_T_antigen pfam02380
T-antigen specific domain; This domain represents a conserved region in papovavirus small and ...
 103-173 3.17e-16

T-antigen specific domain; This domain represents a conserved region in papovavirus small and middle T-antigens. It is found as the N-terminal domain in the small T-antigen, and is centrally located in the middle T-antigen.


Pssm-ID: 367062  Cd Length: 93  Bit Score: 70.11  E-value: 3.17e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1158966714 103 PQCLVMAKSCCTCIASTLINQHLYIKKREGKKCLVWGECFCIFCFALWFGAAHTWETFELWAKIIAQLPKC 173
Cdd:pfam02380  19 PTCLKNVSSNCNCILCLLRKQHKNRKKFLRKPPLVWGECYCYDCYRQWFGLPLTEETLFLWAQIIANTPFR 89
DnaJ smart00271
DnaJ molecular chaperone homology domain;
15-60 7.98e-07

DnaJ molecular chaperone homology domain;


Pssm-ID: 197617 [Multi-domain]  Cd Length: 60  Bit Score: 44.53  E-value: 7.98e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1158966714   15 ELLEVHPQAfyNVPIMKTAFKKACKKWHPDKGGDTT-----KMTLLNSLWQ 60
Cdd:smart00271   5 EILGVPRDA--SLDEIKKAYRKLALKYHPDKNPGDKeeaeeKFKEINEAYE 53
DnaJ cd06257
DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and ...
 15-60 1.14e-03

DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, an important chaperonine family. Hsp40 proteins are characterized by the presence of a J domain, which mediates the interaction with Hsp70. They may contain other domains as well, and the architectures provide a means of classification.


Pssm-ID: 99751 [Multi-domain]  Cd Length: 55  Bit Score: 35.60  E-value: 1.14e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1158966714  15 ELLEVHPQAfyNVPIMKTAFKKACKKWHPDKGGD----TTKMTLLNSLWQ 60
Cdd:cd06257     4 DILGVPPDA--SDEEIKKAYRKLALKYHPDKNPDdpeaEEKFKEINEAYE 51
CbpA COG2214
Curved DNA-binding protein CbpA, contains a DnaJ-like domain [Transcription];
15-48 1.29e-03

Curved DNA-binding protein CbpA, contains a DnaJ-like domain [Transcription];


Pssm-ID: 441816 [Multi-domain]  Cd Length: 91  Bit Score: 36.62  E-value: 1.29e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1158966714  15 ELLEVHPQAfyNVPIMKTAFKKACKKWHPDKGGD 48
Cdd:COG2214     9 AVLGVPPDA--SLEEIRQAYRRLAKLLHPDRGGE 40
DnaJ pfam00226
DnaJ domain; DnaJ domains (J-domains) are associated with hsp70 heat-shock system and it is ...
 15-45 6.49e-03

DnaJ domain; DnaJ domains (J-domains) are associated with hsp70 heat-shock system and it is thought that this domain mediates the interaction. DnaJ-domain is therefore part of a chaperone (protein folding) system. The T-antigens, although not in Prosite are confirmed as DnaJ containing domains from literature.


Pssm-ID: 395170 [Multi-domain]  Cd Length: 63  Bit Score: 33.60  E-value: 6.49e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1158966714  15 ELLEVHPQAfyNVPIMKTAFKKACKKWHPDK 45
Cdd:pfam00226   4 EILGVSPDA--SDEEIKKAYRKLALKYHPDK 32
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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