RecName: Full=Sodium channel protein type 2 subunit alpha; AltName: Full=Sodium channel protein brain II subunit alpha; AltName: Full=Sodium channel protein type II subunit alpha; AltName: Full=Voltage-gated sodium channel subunit alpha Nav1.2
Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain ...
558-709
3.62e-91
Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain towards the start of voltage-dependent sodium ion channel proteins in eukaryotes. It is found closely associated with pfam06512 and pfam00520.
:
Pssm-ID: 463401 Cd Length: 163 Bit Score: 292.79 E-value: 3.62e-91
Sodium ion transport-associated; Members of this family contain a region found exclusively in ...
997-1203
1.83e-83
Sodium ion transport-associated; Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of pfam00520 and, less often, one copy of pfam00612.
:
Pssm-ID: 461936 Cd Length: 195 Bit Score: 271.90 E-value: 1.83e-83
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1207-1482
1.01e-63
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
:
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 217.13 E-value: 1.01e-63
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1531-1786
1.22e-58
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
:
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 202.50 E-value: 1.22e-58
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
758-971
8.65e-55
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
:
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 191.71 E-value: 8.65e-55
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
128-435
3.49e-48
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
:
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 172.45 E-value: 3.49e-48
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of ...
1474-1526
1.16e-31
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of the intracellular linker between domains III and IV of the alpha subunits of voltage-gated sodium channels. It is responsible for fast inactivation of the channel and essential for proper physiological function.
:
Pssm-ID: 240441 Cd Length: 54 Bit Score: 118.44 E-value: 1.16e-31
Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain ...
558-709
3.62e-91
Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain towards the start of voltage-dependent sodium ion channel proteins in eukaryotes. It is found closely associated with pfam06512 and pfam00520.
Pssm-ID: 463401 Cd Length: 163 Bit Score: 292.79 E-value: 3.62e-91
Sodium ion transport-associated; Members of this family contain a region found exclusively in ...
997-1203
1.83e-83
Sodium ion transport-associated; Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of pfam00520 and, less often, one copy of pfam00612.
Pssm-ID: 461936 Cd Length: 195 Bit Score: 271.90 E-value: 1.83e-83
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1207-1482
1.01e-63
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 217.13 E-value: 1.01e-63
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1531-1786
1.22e-58
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 202.50 E-value: 1.22e-58
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
758-971
8.65e-55
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 191.71 E-value: 8.65e-55
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
128-435
3.49e-48
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 172.45 E-value: 3.49e-48
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of ...
1474-1526
1.16e-31
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of the intracellular linker between domains III and IV of the alpha subunits of voltage-gated sodium channels. It is responsible for fast inactivation of the channel and essential for proper physiological function.
Pssm-ID: 240441 Cd Length: 54 Bit Score: 118.44 E-value: 1.16e-31
Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain ...
558-709
3.62e-91
Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain towards the start of voltage-dependent sodium ion channel proteins in eukaryotes. It is found closely associated with pfam06512 and pfam00520.
Pssm-ID: 463401 Cd Length: 163 Bit Score: 292.79 E-value: 3.62e-91
Sodium ion transport-associated; Members of this family contain a region found exclusively in ...
997-1203
1.83e-83
Sodium ion transport-associated; Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of pfam00520 and, less often, one copy of pfam00612.
Pssm-ID: 461936 Cd Length: 195 Bit Score: 271.90 E-value: 1.83e-83
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1207-1482
1.01e-63
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 217.13 E-value: 1.01e-63
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1531-1786
1.22e-58
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 202.50 E-value: 1.22e-58
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
758-971
8.65e-55
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 191.71 E-value: 8.65e-55
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
128-435
3.49e-48
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 172.45 E-value: 3.49e-48
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of ...
1474-1526
1.16e-31
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of the intracellular linker between domains III and IV of the alpha subunits of voltage-gated sodium channels. It is responsible for fast inactivation of the channel and essential for proper physiological function.
Pssm-ID: 240441 Cd Length: 54 Bit Score: 118.44 E-value: 1.16e-31
Polycystin cation channel; This family contains the cation channel region from group II of ...
1562-1780
2.70e-05
Polycystin cation channel; This family contains the cation channel region from group II of Transient receptor potential (TRP) channels, the TRPP subfamily, including PKD1, PKD2, PKD2L and mucolipin proteins.
Pssm-ID: 462341 [Multi-domain] Cd Length: 225 Bit Score: 47.66 E-value: 2.70e-05
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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