NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1191447807|gb|AQY77346|]
View 

NOTCH4 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1618-1822 4.50e-40

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 151.26  E-value: 4.50e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447807 1618 LLDGGACPQAHTVGTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLrSRQTAVDART 1697
Cdd:COG0666     72 LLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLL-EAGADVNAQD 150

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447807 1698 EDGTTPLMLAARLAVEDLVEELIAAQADVGARDKWGKTALHWAAAVNNARAARSLLQAGADKDAQDNREQTPLFLAAREG 1777
Cdd:COG0666    151 NDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENG 230

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 1191447807 1778 AVEVAQLLLGLGAARELRDQAGLAPADVAHQRNHWDLLTLLEGAG 1822
Cdd:COG0666    231 NLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLAL 275
JMTM_Notch4 cd21705
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ...
 1430-1514 2.23e-29

juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 4 (Notch4) and similar proteins; Neurogenic locus notch homolog protein 4 (Notch4) functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. It affects the implementation of differentiation, proliferation and apoptotic programs. This model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch4, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


:

Pssm-ID: 411988  Cd Length: 92  Bit Score: 113.26  E-value: 2.23e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447807 1430 AVHPHAGTAPP---ANQLPWPVLCSPVAGVILLALGALLVLQLIRRRRREHGALWLPPGFTRRPRTQsaPHRRRPPLGED 1506
Cdd:cd21705      7 AVTVEEAEKDPqlvAAQLPWPLVCSSVAGVLALVLGALLGVQLIRRRQREHGALWLPPGFARHRDPN--PHRRREPVGED 84


                   ....*...
gi 1191447807 1507 SIGLKALK 1514
Cdd:cd21705     85 AIGLKPLK 92
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 431-472 4.22e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 50.71  E-value: 4.22e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1191447807  431 DLDECLMaqqgPSPCEHGGSCLNTPGSFNCLCPPGYTGSRCE 472
Cdd:cd00054      1 DIDECAS----GNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1248-1284 5.25e-08

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


:

Pssm-ID: 459658  Cd Length: 35  Bit Score: 50.60  E-value: 5.25e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1191447807 1248 PACTPAYdqyCHDHFHNGHCEKGCNTAECGWDGGDCR 1284
Cdd:pfam00066    2 PNCPYPY---CWDKFGNGVCDEECNNAECLWDGGDCS 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 550-586 1.58e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.17  E-value: 1.58e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1191447807  550 DIDECRS-SPCANGGQCQDQPGAFHCKCLPGFEGPRCQ 586
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 313-352 5.18e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.63  E-value: 5.18e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1191447807  313 DVDECETQGPphCRNGGTCQNSAGSFHCVCVSGWGGTSCE 352
Cdd:cd00054      1 DIDECASGNP--CQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1210-1245 8.40e-07

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


:

Pssm-ID: 459658  Cd Length: 35  Bit Score: 47.14  E-value: 8.40e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1191447807 1210 WKGCPsHSRCWLLFRDGQCHPQCDSEECLFDGYDCE 1245
Cdd:pfam00066    1 WPNCP-YPYCWDKFGNGVCDEECNNAECLWDGGDCS 35
EGF_CA pfam07645
Calcium-binding EGF domain;
193-224 1.94e-06

Calcium-binding EGF domain;


:

Pssm-ID: 429571  Cd Length: 32  Bit Score: 46.08  E-value: 1.94e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1191447807  193 DVNECFQDPGPCPKGTSCHNTLGSFQCLCPVG 224
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 514-548 2.85e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 2.85e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1191447807  514 NECASA-PCLNHADCHDLLNGFQCICLPGFSGTRCE 548
Cdd:cd00054      3 DECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 969-1003 3.64e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.32  E-value: 3.64e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1191447807  969 DACQSQ-PCHNHGTCTPKPGGFHCACPPGFVGLRCE 1003
Cdd:cd00054      3 DECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 768-802 1.11e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 1.11e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1191447807  768 DYCVSA-PCFNGGTCVNRPGTFSCLCAMGFQGPRCE 802
Cdd:cd00054      3 DECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 589-624 2.44e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.01  E-value: 2.44e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1191447807  589 VDECLS-DPCPVGASCLDLPGAFFCLCPSGFTGQLCE 624
Cdd:cd00054      2 IDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 474-510 5.69e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 5.69e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1191447807  474 DHNECLSQ-PCHPGSTCLDLLATFHCLCPPGLEGQLCE 510
Cdd:cd00054      1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1167-1203 1.43e-04

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


:

Pssm-ID: 459658  Cd Length: 35  Bit Score: 40.59  E-value: 1.43e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1191447807 1167 PRCQKPGakgCEGRSGDGACDAGCSGPGGNWDGGDCS 1203
Cdd:pfam00066    2 PNCPYPY---CWDKFGNGVCDEECNNAECLWDGGDCS 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 930-964 2.82e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 2.82e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1191447807  930 VNPCESR-PCQNGATCMAQPSGYLCQCAPGYDGQNC 964
Cdd:cd00054      2 IDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
NOD super family cl08449
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ...
 1294-1343 4.50e-04

NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. Role of NOD domain remains to be elucidated.


The actual alignment was detected with superfamily member pfam06816:

Pssm-ID: 462014  Cd Length: 56  Bit Score: 39.80  E-value: 4.50e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1191447807 1294 PSLAL----LVVLSPP-ALDQQLFALARVLSLTLRVGLWVRKDRDGRDMVYPYPG 1343
Cdd:pfam06816    2 EKLAEgvlvIVVLMDPeELLNNSVQFLRELSTVLRTNVRFKKDENGNPMIYPWYG 56
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 735-764 8.57e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.77  E-value: 8.57e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 1191447807  735 GPCLNGGSCNPSPGGYYCTCPPSHTGPQCQ 764
Cdd:cd00054      9 NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 698-725 1.25e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 1.25e-03
                           10        20
                   ....*....|....*....|....*...
gi 1191447807  698 PCAHGGTCYPQPSGYNCTCPTGYTGPTC 725
Cdd:cd00054     10 PCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 898-927 1.49e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 1.49e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1191447807  898 SLCHNGGLCVDSGPSYFCHCPPGFQGSLCQ 927
Cdd:cd00054      9 NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
NODP super family cl06639
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ...
 1378-1419 1.93e-03

NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. The role of the NOD and NODP domains remains to be elucidated.


The actual alignment was detected with superfamily member pfam07684:

Pssm-ID: 462229  Cd Length: 59  Bit Score: 38.41  E-value: 1.93e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1191447807 1378 AGFVVVMGVDLSRCGPDHpaSRCPWDPGLLLRFLAAMAAVGA 1419
Cdd:pfam07684    2 IGSVVYLEIDNRKCSQSS--DECFSTAQSAADFLAALAAKGG 41
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 363-389 3.75e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 3.75e-03
                           10        20
                   ....*....|....*....|....*..
gi 1191447807  363 CAPGSTCIDRVGSFSCLCPPGRTGLLC 389
Cdd:cd00054     11 CQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 812-841 4.10e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 4.10e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1191447807  812 SPCRNRATCQDSPQGPRCLCPTGYTGGSCQ 841
Cdd:cd00054      9 NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 279-307 9.37e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.44  E-value: 9.37e-03
                           10        20
                   ....*....|....*....|....*....
gi 1191447807  279 CVSHQCQNGGTCQDGLDTYTCLCPETWTG 307
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1046-1083 9.57e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 9.57e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1191447807 1046 IDPCHSQ-PCFHGGTCEATAGSplgFICHCPKGFEGPTC 1083
Cdd:cd00054      2 IDECASGnPCQNGGTCVNTVGS---YRCSCPPGYTGRNC 37
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1618-1822 4.50e-40

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 151.26  E-value: 4.50e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447807 1618 LLDGGACPQAHTVGTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLrSRQTAVDART 1697
Cdd:COG0666     72 LLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLL-EAGADVNAQD 150

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447807 1698 EDGTTPLMLAARLAVEDLVEELIAAQADVGARDKWGKTALHWAAAVNNARAARSLLQAGADKDAQDNREQTPLFLAAREG 1777
Cdd:COG0666    151 NDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENG 230

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 1191447807 1778 AVEVAQLLLGLGAARELRDQAGLAPADVAHQRNHWDLLTLLEGAG 1822
Cdd:COG0666    231 NLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLAL 275
JMTM_Notch4 cd21705
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ...
 1430-1514 2.23e-29

juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 4 (Notch4) and similar proteins; Neurogenic locus notch homolog protein 4 (Notch4) functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. It affects the implementation of differentiation, proliferation and apoptotic programs. This model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch4, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411988  Cd Length: 92  Bit Score: 113.26  E-value: 2.23e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447807 1430 AVHPHAGTAPP---ANQLPWPVLCSPVAGVILLALGALLVLQLIRRRRREHGALWLPPGFTRRPRTQsaPHRRRPPLGED 1506
Cdd:cd21705      7 AVTVEEAEKDPqlvAAQLPWPLVCSSVAGVLALVLGALLGVQLIRRRQREHGALWLPPGFARHRDPN--PHRRREPVGED 84


                   ....*...
gi 1191447807 1507 SIGLKALK 1514
Cdd:cd21705     85 AIGLKPLK 92
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1637-1730 5.52e-17

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 77.85  E-value: 5.52e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447807 1637 LHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLRSRQTAVDartEDGTTPLMLAARLAVEDLV 1716
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLK---DNGRTALHYAARSGHLEIV 77

                           90
                   ....*....|....
gi 1191447807 1717 EELIAAQADVGARD 1730
Cdd:pfam12796   78 KLLLEKGADINVKD 91
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 1618-1790 1.25e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 71.95  E-value: 1.25e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447807 1618 LLDGGACPQaHTVGTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLRSRQTAVDART 1697
Cdd:PHA02875    21 LLDIGINPN-FEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKFADDVFY 99

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447807 1698 EDGTTPLMLAARLAVEDLVEELIA--AQADVGARDKWgkTALHWAAAVNNARAARSLLQAGADKDAQDNREQTPLFLAAR 1775
Cdd:PHA02875   100 KDGMTPLHLATILKKLDIMKLLIArgADPDIPNTDKF--SPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMA 177

                          170
                   ....*....|....*
gi 1191447807 1776 EGAVEVAQLLLGLGA 1790
Cdd:PHA02875   178 KGDIAICKMLLDSGA 192
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 1633-1786 2.56e-08

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 58.87  E-value: 2.56e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447807 1633 GETPLHLAARFSRPTAARRLLEAGanP---NQPDR----AGRTPLHAAVAADAREVCQLLLRSRQTAVDARTED------ 1699
Cdd:cd22192     51 GETALHVAALYDNLEAAVVLMEAA--PelvNEPMTsdlyQGETALHIAVVNQNLNLVRELIARGADVVSPRATGtffrpg 128

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447807 1700 -------GTTPLMLAARLAVEDLVEELIAAQADVGARDKWGKTALHWAAAVNNARAARS----LLQAGADKDAQ------ 1762
Cdd:cd22192    129 pknliyyGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVLHILVLQPNKTFACQmydlILSYDKEDDLQpldlvp 208

                          170       180
                   ....*....|....*....|....
gi 1191447807 1763 DNREQTPLFLAAREGAVEVAQLLL 1786
Cdd:cd22192    209 NNQGLTPFKLAAKEGNIVMFQHLV 232
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 431-472 4.22e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 50.71  E-value: 4.22e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1191447807  431 DLDECLMaqqgPSPCEHGGSCLNTPGSFNCLCPPGYTGSRCE 472
Cdd:cd00054      1 DIDECAS----GNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1248-1284 5.25e-08

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 50.60  E-value: 5.25e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1191447807 1248 PACTPAYdqyCHDHFHNGHCEKGCNTAECGWDGGDCR 1284
Cdd:pfam00066    2 PNCPYPY---CWDKFGNGVCDEECNNAECLWDGGDCS 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 550-586 1.58e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.17  E-value: 1.58e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1191447807  550 DIDECRS-SPCANGGQCQDQPGAFHCKCLPGFEGPRCQ 586
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
431-472 2.28e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.78  E-value: 2.28e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1191447807   431 DLDECLMaqqgPSPCEHGGSCLNTPGSFNCLCPPGYT-GSRCE 472
Cdd:smart00179    1 DIDECAS----GNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 1243-1283 3.10e-07

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 48.48  E-value: 3.10e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1191447807  1243 DCETPPACTpayDQYCHDHFHNGHCEKGCNTAECGWDGGDC 1283
Cdd:smart00004    1 PQDPWSRCE---DAQCWDKFGDGVCDEECNNAECLWDGGDC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 313-352 5.18e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.63  E-value: 5.18e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1191447807  313 DVDECETQGPphCRNGGTCQNSAGSFHCVCVSGWGGTSCE 352
Cdd:cd00054      1 DIDECASGNP--CQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1210-1245 8.40e-07

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 47.14  E-value: 8.40e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1191447807 1210 WKGCPsHSRCWLLFRDGQCHPQCDSEECLFDGYDCE 1245
Cdd:pfam00066    1 WPNCP-YPYCWDKFGNGVCDEECNNAECLWDGGDCS 35
EGF_CA pfam07645
Calcium-binding EGF domain;
193-224 1.94e-06

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 46.08  E-value: 1.94e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1191447807  193 DVNECFQDPGPCPKGTSCHNTLGSFQCLCPVG 224
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 1206-1244 2.76e-06

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 45.78  E-value: 2.76e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1191447807  1206 VPDPWKGCPsHSRCWLLFRDGQCHPQCDSEECLFDGYDC 1244
Cdd:smart00004    1 PQDPWSRCE-DAQCWDKFGDGVCDEECNNAECLWDGGDC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 514-548 2.85e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 2.85e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1191447807  514 NECASA-PCLNHADCHDLLNGFQCICLPGFSGTRCE 548
Cdd:cd00054      3 DECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 969-1003 3.64e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.32  E-value: 3.64e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1191447807  969 DACQSQ-PCHNHGTCTPKPGGFHCACPPGFVGLRCE 1003
Cdd:cd00054      3 DECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
550-586 3.70e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 3.70e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1191447807   550 DIDECRS-SPCANGGQCQDQPGAFHCKCLPGFE-GPRCQ 586
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
313-352 5.37e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.93  E-value: 5.37e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1191447807   313 DVDECETQGPphCRNGGTCQNSAGSFHCVCVSGW-GGTSCE 352
Cdd:smart00179    1 DIDECASGNP--CQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 193-231 5.89e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 5.89e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1191447807  193 DVNECfQDPGPCPKGTSCHNTLGSFQCLCPVGQEGPRCE 231
Cdd:cd00054      1 DIDEC-ASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 768-802 1.11e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 1.11e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1191447807  768 DYCVSA-PCFNGGTCVNRPGTFSCLCAMGFQGPRCE 802
Cdd:cd00054      3 DECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
193-231 1.40e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 1.40e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1191447807   193 DVNECfQDPGPCPKGTSCHNTLGSFQCLCPVG-QEGPRCE 231
Cdd:smart00179    1 DIDEC-ASGNPCQNGGTCVNTVGSYRCECPPGyTDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 589-624 2.44e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.01  E-value: 2.44e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1191447807  589 VDECLS-DPCPVGASCLDLPGAFFCLCPSGFTGQLCE 624
Cdd:cd00054      2 IDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 474-510 5.69e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 5.69e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1191447807  474 DHNECLSQ-PCHPGSTCLDLLATFHCLCPPGLEGQLCE 510
Cdd:cd00054      1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
514-548 5.83e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 5.83e-05
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1191447807   514 NECASA-PCLNHADCHDLLNGFQCICLPGFS-GTRCE 548
Cdd:smart00179    3 DECASGnPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
313-345 1.25e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 40.68  E-value: 1.25e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1191447807  313 DVDECETqGPPHCRNGGTCQNSAGSFHCVCVSG 345
Cdd:pfam07645    1 DVDECAT-GTHNCPANTVCVNTIGSFECRCPDG 32
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1167-1203 1.43e-04

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 40.59  E-value: 1.43e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1191447807 1167 PRCQKPGakgCEGRSGDGACDAGCSGPGGNWDGGDCS 1203
Cdd:pfam00066    2 PNCPYPY---CWDKFGNGVCDEECNNAECLWDGGDCS 35
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 971-1001 1.57e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 40.44  E-value: 1.57e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1191447807  971 CQSQPCHNHGTCTPKPGGFHCACPPGFVGLR 1001
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
768-802 2.03e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 2.03e-04
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1191447807   768 DYCVSA-PCFNGGTCVNRPGTFSCLCAMGFQ-GPRCE 802
Cdd:smart00179    3 DECASGnPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 1164-1202 2.16e-04

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 40.39  E-value: 2.16e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1191447807  1164 SPGPRCQkpgAKGCEGRSGDGACDAGCSGPGGNWDGGDC 1202
Cdd:smart00004    3 DPWSRCE---DAQCWDKFGDGVCDEECNNAECLWDGGDC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 930-964 2.82e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 2.82e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1191447807  930 VNPCESR-PCQNGATCMAQPSGYLCQCAPGYDGQNC 964
Cdd:cd00054      2 IDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
969-1003 3.39e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 3.39e-04
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1191447807   969 DACQS-QPCHNHGTCTPKPGGFHCACPPGFV-GLRCE 1003
Cdd:smart00179    3 DECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
431-465 4.00e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 39.53  E-value: 4.00e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1191447807  431 DLDECLmaqQGPSPCEHGGSCLNTPGSFNCLCPPG 465
Cdd:pfam07645    1 DVDECA---TGTHNCPANTVCVNTIGSFECRCPDG 32
NOD pfam06816
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ...
 1294-1343 4.50e-04

NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. Role of NOD domain remains to be elucidated.


Pssm-ID: 462014  Cd Length: 56  Bit Score: 39.80  E-value: 4.50e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1191447807 1294 PSLAL----LVVLSPP-ALDQQLFALARVLSLTLRVGLWVRKDRDGRDMVYPYPG 1343
Cdd:pfam06816    2 EKLAEgvlvIVVLMDPeELLNNSVQFLRELSTVLRTNVRFKKDENGNPMIYPWYG 56
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 770-800 6.09e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.90  E-value: 6.09e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1191447807  770 CVSAPCFNGGTCVNRPGTFSCLCAMGFQGPR 800
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 735-764 8.57e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.77  E-value: 8.57e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 1191447807  735 GPCLNGGSCNPSPGGYYCTCPPSHTGPQCQ 764
Cdd:cd00054      9 NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
588-624 8.88e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 8.88e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1191447807   588 EVDECLS-DPCPVGASCLDLPGAFFCLCPSGFT-GQLCE 624
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
474-510 1.09e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.09e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1191447807   474 DHNECLS-QPCHPGSTCLDLLATFHCLCPPGLE-GQLCE 510
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 698-725 1.25e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 1.25e-03
                           10        20
                   ....*....|....*....|....*...
gi 1191447807  698 PCAHGGTCYPQPSGYNCTCPTGYTGPTC 725
Cdd:cd00054     10 PCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 898-927 1.49e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 1.49e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1191447807  898 SLCHNGGLCVDSGPSYFCHCPPGFQGSLCQ 927
Cdd:cd00054      9 NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
NODP pfam07684
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ...
 1378-1419 1.93e-03

NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. The role of the NOD and NODP domains remains to be elucidated.


Pssm-ID: 462229  Cd Length: 59  Bit Score: 38.41  E-value: 1.93e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1191447807 1378 AGFVVVMGVDLSRCGPDHpaSRCPWDPGLLLRFLAAMAAVGA 1419
Cdd:pfam07684    2 IGSVVYLEIDNRKCSQSS--DECFSTAQSAADFLAALAAKGG 41
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 933-963 2.51e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.98  E-value: 2.51e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1191447807  933 CESRPCQNGATCMAQPSGYLCQCAPGYDGQN 963
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 732-762 2.66e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.98  E-value: 2.66e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1191447807  732 CHSGPCLNGGSCNPSPGGYYCTCPPSHTGPQ 762
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
930-964 3.49e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 3.49e-03
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1191447807   930 VNPCESR-PCQNGATCMAQPSGYLCQCAPGY-DGQNC 964
Cdd:smart00179    2 IDECASGnPCQNGGTCVNTVGSYRCECPPGYtDGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 363-389 3.75e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 3.75e-03
                           10        20
                   ....*....|....*....|....*..
gi 1191447807  363 CAPGSTCIDRVGSFSCLCPPGRTGLLC 389
Cdd:cd00054     11 CQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 812-841 4.10e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 4.10e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1191447807  812 SPCRNRATCQDSPQGPRCLCPTGYTGGSCQ 841
Cdd:cd00054      9 NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 809-837 6.77e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.82  E-value: 6.77e-03
                           10        20
                   ....*....|....*....|....*....
gi 1191447807  809 CADSPCRNRATCQDSPQGPRCLCPTGYTG 837
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 279-307 9.37e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.44  E-value: 9.37e-03
                           10        20
                   ....*....|....*....|....*....
gi 1191447807  279 CVSHQCQNGGTCQDGLDTYTCLCPETWTG 307
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1046-1083 9.57e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 9.57e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1191447807 1046 IDPCHSQ-PCFHGGTCEATAGSplgFICHCPKGFEGPTC 1083
Cdd:cd00054      2 IDECASGnPCQNGGTCVNTVGS---YRCSCPPGYTGRNC 37
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1618-1822 4.50e-40

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 151.26  E-value: 4.50e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447807 1618 LLDGGACPQAHTVGTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLrSRQTAVDART 1697
Cdd:COG0666     72 LLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLL-EAGADVNAQD 150

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447807 1698 EDGTTPLMLAARLAVEDLVEELIAAQADVGARDKWGKTALHWAAAVNNARAARSLLQAGADKDAQDNREQTPLFLAAREG 1777
Cdd:COG0666    151 NDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENG 230

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 1191447807 1778 AVEVAQLLLGLGAARELRDQAGLAPADVAHQRNHWDLLTLLEGAG 1822
Cdd:COG0666    231 NLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLAL 275
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1633-1822 2.52e-37

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 143.17  E-value: 2.52e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447807 1633 GETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLrSRQTAVDARTEDGTTPLMLAARLAV 1712
Cdd:COG0666     54 GALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLL-EAGADVNARDKDGETPLHLAAYNGN 132

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447807 1713 EDLVEELIAAQADVGARDKWGKTALHWAAAVNNARAARSLLQAGADKDAQDNREQTPLFLAAREGAVEVAQLLLGLGAAR 1792
Cdd:COG0666    133 LEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADV 212

                          170       180       190
                   ....*....|....*....|....*....|
gi 1191447807 1793 ELRDQAGLAPADVAHQRNHWDLLTLLEGAG 1822
Cdd:COG0666    213 NAKDNDGKTALDLAAENGNLEIVKLLLEAG 242
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1576-1803 4.74e-36

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 139.32  E-value: 4.74e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447807 1576 APDLDTRGPDGVTPLMSAVCCGEVQSGTFqgawlgcpepwepLLDGGACPQAHTVGtGETPLHLAARFSRPTAARRLLEA 1655
Cdd:COG0666     77 GADINAKDDGGNTLLHAAARNGDLEIVKL-------------LLEAGADVNARDKD-GETPLHLAAYNGNLEIVKLLLEA 142

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447807 1656 GANPNQPDRAGRTPLHAAVAADAREVCQLLLrSRQTAVDARTEDGTTPLMLAARLAVEDLVEELIAAQADVGARDKWGKT 1735
Cdd:COG0666    143 GADVNAQDNDGNTPLHLAAANGNLEIVKLLL-EAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKT 221

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1191447807 1736 ALHWAAAVNNARAARSLLQAGADKDAQDNREQTPLFLAAREGAVEVAQLLLGLGAARELRDQAGLAPA 1803
Cdd:COG0666    222 ALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
JMTM_Notch4 cd21705
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ...
 1430-1514 2.23e-29

juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 4 (Notch4) and similar proteins; Neurogenic locus notch homolog protein 4 (Notch4) functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. It affects the implementation of differentiation, proliferation and apoptotic programs. This model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch4, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411988  Cd Length: 92  Bit Score: 113.26  E-value: 2.23e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447807 1430 AVHPHAGTAPP---ANQLPWPVLCSPVAGVILLALGALLVLQLIRRRRREHGALWLPPGFTRRPRTQsaPHRRRPPLGED 1506
Cdd:cd21705      7 AVTVEEAEKDPqlvAAQLPWPLVCSSVAGVLALVLGALLGVQLIRRRQREHGALWLPPGFARHRDPN--PHRRREPVGED 84


                   ....*...
gi 1191447807 1507 SIGLKALK 1514
Cdd:cd21705     85 AIGLKPLK 92
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1637-1822 5.72e-29

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 118.90  E-value: 5.72e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447807 1637 LHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLRSRQTAVDARTEDGTTPLMLAARLAVEDLV 1716
Cdd:COG0666     24 LLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIV 103

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447807 1717 EELIAAQADVGARDKWGKTALHWAAAVNNARAARSLLQAGADKDAQDNREQTPLFLAAREGAVEVAQLLLGLGAARELRD 1796
Cdd:COG0666    104 KLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARD 183

                          170       180
                   ....*....|....*....|....*.
gi 1191447807 1797 QAGLAPADVAHQRNHWDLLTLLEGAG 1822
Cdd:COG0666    184 NDGETPLHLAAENGHLEIVKLLLEAG 209
JMTM_Notch cd21701
juxtamembrane and transmembrane (JMTM) domain found in Notch protein family; Neurogenic locus ...
 1430-1513 1.05e-19

juxtamembrane and transmembrane (JMTM) domain found in Notch protein family; Neurogenic locus notch homolog (Notch) proteins are a family of type-1 transmembrane proteins that form a core component of the Notch signaling pathway. They operate in a variety of different tissues and play a role in a variety of developmental processes by controlling cell fate decisions. The model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch proteins, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411984  Cd Length: 85  Bit Score: 85.12  E-value: 1.05e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447807 1430 AVHPHAGTAPPAnQLPWPVLCSPVAGVILLALGALLVLQLIRRRRReHGALWLPPGFTRRPRTQsaPHRRRPPLGEDSIG 1509
Cdd:cd21701      6 SVRSEPGPATKT-TPPAQLSPLVVAAVCVLLVLVVLGVLVARKRRR-HGTLWFPEGFPRTRASR--RSRRRDPVGQDSVG 81


                   ....
gi 1191447807 1510 LKAL 1513
Cdd:cd21701     82 LKNL 85
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1652-1822 9.87e-18

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 85.78  E-value: 9.87e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447807 1652 LLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLRSRQTAVDARTEDGTTPLMLAARLAVEDLVEELIAAQADVGARDK 1731
Cdd:COG0666      6 LLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDD 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447807 1732 WGKTALHWAAAVNNARAARSLLQAGADKDAQDNREQTPLFLAAREGAVEVAQLLLGLGAARELRDQAGLAPADVAHQRNH 1811
Cdd:COG0666     86 GGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGN 165

                          170
                   ....*....|.
gi 1191447807 1812 WDLLTLLEGAG 1822
Cdd:COG0666    166 LEIVKLLLEAG 176
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1637-1730 5.52e-17

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 77.85  E-value: 5.52e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447807 1637 LHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLRSRQTAVDartEDGTTPLMLAARLAVEDLV 1716
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLK---DNGRTALHYAARSGHLEIV 77

                           90
                   ....*....|....
gi 1191447807 1717 EELIAAQADVGARD 1730
Cdd:pfam12796   78 KLLLEKGADINVKD 91
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 1618-1790 1.25e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 71.95  E-value: 1.25e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447807 1618 LLDGGACPQaHTVGTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLRSRQTAVDART 1697
Cdd:PHA02875    21 LLDIGINPN-FEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKFADDVFY 99

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447807 1698 EDGTTPLMLAARLAVEDLVEELIA--AQADVGARDKWgkTALHWAAAVNNARAARSLLQAGADKDAQDNREQTPLFLAAR 1775
Cdd:PHA02875   100 KDGMTPLHLATILKKLDIMKLLIArgADPDIPNTDKF--SPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMA 177

                          170
                   ....*....|....*
gi 1191447807 1776 EGAVEVAQLLLGLGA 1790
Cdd:PHA02875   178 KGDIAICKMLLDSGA 192
JMTM_Notch1 cd21702
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ...
 1471-1514 3.42e-12

juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 1 (Notch1) and similar proteins; Neurogenic locus notch homolog protein 1 (Notch1), also called translocation-associated notch protein TAN-1, functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. It affects the implementation of differentiation, proliferation and apoptotic programs. It is also involved in angiogenesis, and also negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. This model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch1, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411985  Cd Length: 80  Bit Score: 63.66  E-value: 3.42e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1191447807 1471 RRRRREHGALWLPPGFTrrpRTQSAPHRRRPPLGEDSIGLKALK 1514
Cdd:cd21702     39 RKRRREHGQLWFPEGFK---VSEPSKKKRREPVGEDSVGLKPLK 79
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 1618-1776 1.54e-11

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 69.14  E-value: 1.54e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447807 1618 LLDGGACPQAHTVGTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLRSrQTAVDART 1697
Cdd:PHA02878   153 LLSYGADINMKDRHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLEN-GASTDARD 231

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447807 1698 EDGTTPLMLA-ARLAVEDLVEELIAAQADVGARDK-WGKTALHwaAAVNNARAARSLLQAGADKDAQDNREQTPLFLAAR 1775
Cdd:PHA02878   232 KCGNTPLHISvGYCKDYDILKLLLEHGVDVNAKSYiLGLTALH--SSIKSERKLKLLLEYGADINSLNSYKLTPLSSAVK 309


                   .
gi 1191447807 1776 E 1776
Cdd:PHA02878   310 Q 310
PHA03095 PHA03095
ankyrin-like protein; Provisional
 1650-1790 2.42e-11

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 68.51  E-value: 2.42e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447807 1650 RRLLEAGANPNQPDRAGRTPLHAAVA---ADAREVCQLLLRSrQTAVDARTEDGTTPLMLAARLA-VEDLVEELIAAQAD 1725
Cdd:PHA03095    31 RRLLAAGADVNFRGEYGKTPLHLYLHyssEKVKDIVRLLLEA-GADVNAPERCGFTPLHLYLYNAtTLDVIKLLIKAGAD 109

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1191447807 1726 VGARDKWGKTALHWAAAVNNARAA--RSLLQAGADKDAQDNREQTPL--FLAAREGAVEVAQLLLGLGA 1790
Cdd:PHA03095   110 VNAKDKVGRTPLHVYLSGFNINPKviRLLLRKGADVNALDLYGMTPLavLLKSRNANVELLRLLIDAGA 178
PHA03095 PHA03095
ankyrin-like protein; Provisional
 1577-1826 2.55e-11

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 68.51  E-value: 2.55e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447807 1577 PDLDTRGPDGVTPLMSAVCCGEVQsgtfqgawlgCPEPWEPLLDGGACPQAHTVgTGETPLHLAARFS-RPTAARRLLEA 1655
Cdd:PHA03095    38 ADVNFRGEYGKTPLHLYLHYSSEK----------VKDIVRLLLEAGADVNAPER-CGFTPLHLYLYNAtTLDVIKLLIKA 106

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447807 1656 GANPNQPDRAGRTPLHA-----AVAADareVCQLLLRsRQTAVDARTEDGTTPL----------------MLAA---RLA 1711
Cdd:PHA03095   107 GADVNAKDKVGRTPLHVylsgfNINPK---VIRLLLR-KGADVNALDLYGMTPLavllksrnanvellrlLIDAgadVYA 182

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447807 1712 VED------------------LVEELIAAQADVGARDKWGKTALHWAAAVNNARAA--RSLLQAGADKDAQDNREQTPLF 1771
Cdd:PHA03095   183 VDDrfrsllhhhlqsfkprarIVRELIRAGCDPAATDMLGNTPLHSMATGSSCKRSlvLPLLIAGISINARNRYGQTPLH 262

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1191447807 1772 LAAREGAVEVAQLLLGLGAARELRDQAGLAPADVAHQRNHWDLL-TLLEGAGPPEA 1826
Cdd:PHA03095   263 YAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVrAALAKNPSAET 318
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1704-1790 4.67e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 60.90  E-value: 4.67e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447807 1704 LMLAARLAVEDLVEELIAAQADVGARDKWGKTALHWaAAVNNARAARSLLQAGADKDAQDNReQTPLFLAAREGAVEVAQ 1783
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHL-AAKNGHLEIVKLLLEHADVNLKDNG-RTALHYAARSGHLEIVK 78


                   ....*..
gi 1191447807 1784 LLLGLGA 1790
Cdd:pfam12796   79 LLLEKGA 85
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1670-1763 1.41e-10

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 59.74  E-value: 1.41e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447807 1670 LHAAVAADAREVCQLLLRSRqTAVDARTEDGTTPLMLAARLAVEDLVEELIAaQADVGARDKwGKTALHWAAAVNNARAA 1749
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENG-ADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDN-GRTALHYAARSGHLEIV 77

                           90
                   ....*....|....
gi 1191447807 1750 RSLLQAGADKDAQD 1763
Cdd:pfam12796   78 KLLLEKGADINVKD 91
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1618-1695 8.55e-10

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 63.76  E-value: 8.55e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1191447807 1618 LLDGGACPQAHTVgTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLRSRQTAVDA 1695
Cdd:PTZ00322   101 LLTGGADPNCRDY-DGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQCHFEL 177
JMTM_Notch2 cd21703
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ...
 1472-1513 8.94e-10

juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 2 (Notch2) and similar proteins; Neurogenic locus notch homolog protein 2 (Notch2) functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Notch2 is involved in bone remodeling and homeostasis. In collaboration with RELA/p65, it enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation. Notch2 positively regulates self-renewal of liver cancer cells. This model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch2, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411986  Cd Length: 82  Bit Score: 57.08  E-value: 8.94e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1191447807 1472 RRRREHGALWLPPGFTrrPRTQSAPHRRRPPLGEDSIGLKAL 1513
Cdd:cd21703     43 KRKRKHGPLWFPEGFI--LNKENSNRKRREPVGQDAVGMKNL 82
Ank_4 pfam13637
Ankyrin repeats (many copies);
1635-1686 2.31e-09

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 54.97  E-value: 2.31e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1191447807 1635 TPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLL 1686
Cdd:pfam13637    3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1684-1822 3.94e-09

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 59.97  E-value: 3.94e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447807 1684 LLLRSRQTAVDARTEDGTTPLMLAARLAVEDLVEELIAAQADVGARDKWGKTALHWAAAVNNARAARSLLQAGADKDAQD 1763
Cdd:COG0666      5 LLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKD 84

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1191447807 1764 NREQTPLFLAAREGAVEVAQLLLGLGAARELRDQAGLAPADVAHQRNHWDLLTLLEGAG 1822
Cdd:COG0666     85 DGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAG 143
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 1618-1823 7.24e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 60.45  E-value: 7.24e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447807 1618 LLDGGACPQAHTVGTgETPLHLAARF-----SRPTAARRLLEAGANPNQPDRAGRTPLHAAVAadaREVCQL----LLRS 1688
Cdd:PHA03100    54 LLDNGADINSSTKNN-STPLHYLSNIkynltDVKEIVKLLLEYGANVNAPDNNGITPLLYAIS---KKSNSYsiveYLLD 129

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447807 1689 RQTAVDARTEDGTTPLMLAARLAVEDL--VEELIAAQADVGARDKwgktalhwaaavnnaraARSLLQAGADKDAQDNRE 1766
Cdd:PHA03100   130 NGANVNIKNSDGENLLHLYLESNKIDLkiLKLLIDKGVDINAKNR-----------------VNYLLSYGVPINIKDVYG 192

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1191447807 1767 QTPLFLAAREGAVEVAQLLLGLGAARELRDQAGLAPADVAHQRNHWDLLTLLEGAGP 1823
Cdd:PHA03100   193 FTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGP 249
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 1652-1797 1.43e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 60.08  E-value: 1.43e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447807 1652 LLEAGANPNQPDRAGRTPLHAAVAADA--REVCQLLlrSRQTAVDARTEDGTTPLMLAARLAVE-DLVEELIAAQADVGA 1728
Cdd:PHA02876   259 LYDAGFSVNSIDDCKNTPLHHASQAPSlsRLVPKLL--ERGADVNAKNIKGETPLYLMAKNGYDtENIRTLIMLGADVNA 336

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447807 1729 RDKWGKTALHWAAAVNNARAAR-SLLQAGADKDAQDNREQTPLFLAAREGAVEVAQLLLGLGAARELRDQ 1797
Cdd:PHA02876   337 ADRLYITPLHQASTLDRNKDIViTLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQ 406
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 1633-1786 2.56e-08

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 58.87  E-value: 2.56e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447807 1633 GETPLHLAARFSRPTAARRLLEAGanP---NQPDR----AGRTPLHAAVAADAREVCQLLLRSRQTAVDARTED------ 1699
Cdd:cd22192     51 GETALHVAALYDNLEAAVVLMEAA--PelvNEPMTsdlyQGETALHIAVVNQNLNLVRELIARGADVVSPRATGtffrpg 128

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447807 1700 -------GTTPLMLAARLAVEDLVEELIAAQADVGARDKWGKTALHWAAAVNNARAARS----LLQAGADKDAQ------ 1762
Cdd:cd22192    129 pknliyyGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVLHILVLQPNKTFACQmydlILSYDKEDDLQpldlvp 208

                          170       180
                   ....*....|....*....|....
gi 1191447807 1763 DNREQTPLFLAAREGAVEVAQLLL 1786
Cdd:cd22192    209 NNQGLTPFKLAAKEGNIVMFQHLV 232
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 431-472 4.22e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 50.71  E-value: 4.22e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1191447807  431 DLDECLMaqqgPSPCEHGGSCLNTPGSFNCLCPPGYTGSRCE 472
Cdd:cd00054      1 DIDECAS----GNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1248-1284 5.25e-08

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 50.60  E-value: 5.25e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1191447807 1248 PACTPAYdqyCHDHFHNGHCEKGCNTAECGWDGGDCR 1284
Cdd:pfam00066    2 PNCPYPY---CWDKFGNGVCDEECNNAECLWDGGDCS 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 550-586 1.58e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.17  E-value: 1.58e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1191447807  550 DIDECRS-SPCANGGQCQDQPGAFHCKCLPGFEGPRCQ 586
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
431-472 2.28e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.78  E-value: 2.28e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1191447807   431 DLDECLMaqqgPSPCEHGGSCLNTPGSFNCLCPPGYT-GSRCE 472
Cdd:smart00179    1 DIDECAS----GNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 1243-1283 3.10e-07

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 48.48  E-value: 3.10e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1191447807  1243 DCETPPACTpayDQYCHDHFHNGHCEKGCNTAECGWDGGDC 1283
Cdd:smart00004    1 PQDPWSRCE---DAQCWDKFGDGVCDEECNNAECLWDGGDC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 313-352 5.18e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.63  E-value: 5.18e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1191447807  313 DVDECETQGPphCRNGGTCQNSAGSFHCVCVSGWGGTSCE 352
Cdd:cd00054      1 DIDECASGNP--CQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1210-1245 8.40e-07

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 47.14  E-value: 8.40e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1191447807 1210 WKGCPsHSRCWLLFRDGQCHPQCDSEECLFDGYDCE 1245
Cdd:pfam00066    1 WPNCP-YPYCWDKFGNGVCDEECNNAECLWDGGDCS 35
JMTM_Notch3 cd21704
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ...
 1470-1511 9.52e-07

juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 3 (Notch3) and similar proteins; Neurogenic locus notch homolog protein 3 (Notch3) functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. The model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch3, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411987  Cd Length: 90  Bit Score: 48.59  E-value: 9.52e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1191447807 1470 IRRRRREHGALWLPPGFTRrpRTQSAPHRRRPPLGEDSIGLK 1511
Cdd:cd21704     47 VARRKREHSTLWFPEGFFL--KKESSNKNRREPVGQDALGMK 86
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1752-1850 9.54e-07

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 54.13  E-value: 9.54e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447807 1752 LLQAGADKDAQDNREQTPLFLAAREGAVEVAQLLLGLGAARELRDQAGLAPADVAHQRNHWDLLTLL----------EGA 1821
Cdd:PTZ00322   101 LLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLsrhsqchfelGAN 180

                           90       100
                   ....*....|....*....|....*....
gi 1191447807 1822 GPPEARHKATPGREAGPFPRARTVSVSVP 1850
Cdd:PTZ00322   181 AKPDSFTGKPPSLEDSPISSHHPDFSAVP 209
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 1616-1827 1.31e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 53.53  E-value: 1.31e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447807 1616 EPLLDGGACPQAHTVGTgETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLlrsrqtaVDA 1695
Cdd:PHA02876   162 EMLLEGGADVNAKDIYC-ITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAI-------IDN 233

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447807 1696 RTEDGTTPLMLAARLAVEDLVEELIAAQA--DVGARDKWGKTALHWAAAVNN-ARAARSLLQAGADKDAQDNREQTPLFL 1772
Cdd:PHA02876   234 RSNINKNDLSLLKAIRNEDLETSLLLYDAgfSVNSIDDCKNTPLHHASQAPSlSRLVPKLLERGADVNAKNIKGETPLYL 313

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1191447807 1773 AAREG-AVEVAQLLLGLGAARELRDQAGLAPADVAH--QRNHWDLLTLLEGAGPPEAR 1827
Cdd:PHA02876   314 MAKNGyDTENIRTLIMLGADVNAADRLYITPLHQAStlDRNKDIVITLLELGANVNAR 371
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 1635-1773 1.52e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 53.53  E-value: 1.52e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447807 1635 TPLHLAARfsRPTAAR---RLLEAGANPNQPDRAGRTPLH--AAVAADAREVCQLLlrSRQTAVDARTEDGTTPLMLAAR 1709
Cdd:PHA02876   275 TPLHHASQ--APSLSRlvpKLLERGADVNAKNIKGETPLYlmAKNGYDTENIRTLI--MLGADVNAADRLYITPLHQAST 350

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1191447807 1710 L-AVEDLVEELIAAQADVGARDKWGKTALHWAAAVNNARAARSLLQAGADKDAQDNREQTPLFLA 1773
Cdd:PHA02876   351 LdRNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFA 415
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 1618-1796 1.70e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 53.14  E-value: 1.70e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447807 1618 LLDGGACPQAHTVgTGETPLHLAARFSRPTA-ARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLRSRQTAVDAR 1696
Cdd:PHA02876   293 LLERGADVNAKNI-KGETPLYLMAKNGYDTEnIRTLIMLGADVNAADRLYITPLHQASTLDRNKDIVITLLELGANVNAR 371

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447807 1697 TEDGTTPLMLAA--------------RLAVEDL--------------------VEELIAAQADVGARDKWGKTALHWAAA 1742
Cdd:PHA02876   372 DYCDKTPIHYAAvrnnvviintlldyGADIEALsqkigtalhfalcgtnpymsVKTLIDRGANVNSKNKDLSTPLHYACK 451

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1191447807 1743 VNNARAARS-LLQAGADKDAQDNREQTPLFLAAreGAVEVAQLLLGLGAarELRD 1796
Cdd:PHA02876   452 KNCKLDVIEmLLDNGADVNAINIQNQYPLLIAL--EYHGIVNILLHYGA--ELRD 502
Ank_5 pfam13857
Ankyrin repeats (many copies);
1618-1673 1.92e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 46.57  E-value: 1.92e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1191447807 1618 LLDGGACPQAHTVGTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAA 1673
Cdd:pfam13857    1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
EGF_CA pfam07645
Calcium-binding EGF domain;
193-224 1.94e-06

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 46.08  E-value: 1.94e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1191447807  193 DVNECFQDPGPCPKGTSCHNTLGSFQCLCPVG 224
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 1206-1244 2.76e-06

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 45.78  E-value: 2.76e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1191447807  1206 VPDPWKGCPsHSRCWLLFRDGQCHPQCDSEECLFDGYDC 1244
Cdd:smart00004    1 PQDPWSRCE-DAQCWDKFGDGVCDEECNNAECLWDGGDC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 514-548 2.85e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 2.85e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1191447807  514 NECASA-PCLNHADCHDLLNGFQCICLPGFSGTRCE 548
Cdd:cd00054      3 DECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 969-1003 3.64e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.32  E-value: 3.64e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1191447807  969 DACQSQ-PCHNHGTCTPKPGGFHCACPPGFVGLRCE 1003
Cdd:cd00054      3 DECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
550-586 3.70e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 3.70e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1191447807   550 DIDECRS-SPCANGGQCQDQPGAFHCKCLPGFE-GPRCQ 586
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
313-352 5.37e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.93  E-value: 5.37e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1191447807   313 DVDECETQGPphCRNGGTCQNSAGSFHCVCVSGW-GGTSCE 352
Cdd:smart00179    1 DIDECASGNP--CQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 193-231 5.89e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 5.89e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1191447807  193 DVNECfQDPGPCPKGTSCHNTLGSFQCLCPVGQEGPRCE 231
Cdd:cd00054      1 DIDEC-ASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1578-1663 6.38e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 46.26  E-value: 6.38e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447807 1578 DLDTRGPDGVTPLMSAVCCGEVQSGTFqgawlgcpepwepLLDggaCPQAHTVGTGETPLHLAARFSRPTAARRLLEAGA 1657
Cdd:pfam12796   22 DANLQDKNGRTALHLAAKNGHLEIVKL-------------LLE---HADVNLKDNGRTALHYAARSGHLEIVKLLLEKGA 85


                   ....*.
gi 1191447807 1658 NPNQPD 1663
Cdd:pfam12796   86 DINVKD 91
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 1633-1692 1.03e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 50.05  E-value: 1.03e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447807 1633 GETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLRSRQTA 1692
Cdd:PHA03100   192 GFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSI 251
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1752-1818 1.11e-05

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 45.49  E-value: 1.11e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1191447807 1752 LLQAGADKDAQDNREQTPLFLAAREGAVEVAQLLLGLGAARElrDQAGLAPADVAHQRNHWDLLTLL 1818
Cdd:pfam12796   16 LLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNL--KDNGRTALHYAARSGHLEIVKLL 80
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 768-802 1.11e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 1.11e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1191447807  768 DYCVSA-PCFNGGTCVNRPGTFSCLCAMGFQGPRCE 802
Cdd:cd00054      3 DECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
193-231 1.40e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 1.40e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1191447807   193 DVNECfQDPGPCPKGTSCHNTLGSFQCLCPVG-QEGPRCE 231
Cdd:smart00179    1 DIDEC-ASGNPCQNGGTCVNTVGSYRCECPPGyTDGRNCE 39
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1638-1719 1.58e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 49.90  E-value: 1.58e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447807 1638 HLAARfSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLR--SRQTAVDartEDGTTPLMLAARLAVEDL 1715
Cdd:PTZ00322    88 QLAAS-GDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEfgADPTLLD---KDGKTPLELAEENGFREV 163


                   ....
gi 1191447807 1716 VEEL 1719
Cdd:PTZ00322   164 VQLL 167
Ank_5 pfam13857
Ankyrin repeats (many copies);
1652-1707 2.03e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 43.87  E-value: 2.03e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1191447807 1652 LLEAG-ANPNQPDRAGRTPLHAAVAADAREVCQLLLRSRQtAVDARTEDGTTPLMLA 1707
Cdd:pfam13857    1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGV-DLNLKDEEGLTALDLA 56
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 589-624 2.44e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.01  E-value: 2.44e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1191447807  589 VDECLS-DPCPVGASCLDLPGAFFCLCPSGFTGQLCE 624
Cdd:cd00054      2 IDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
PHA02946 PHA02946
ankyin-like protein; Provisional
 1616-1786 4.20e-05

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 48.51  E-value: 4.20e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447807 1616 EPLLDGGACPQaHTVGTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAR--EVCQLLLRSRQTAV 1693
Cdd:PHA02946    56 EELLHRGYSPN-ETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLYYLSGTDDEviERINLLVQYGAKIN 134

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447807 1694 DARTEDGTTPLmLAARLAVEDLVEELIAAQADVGARDKWGKTAL--HWAAAVNNARAARSLLQAGADKDAQDNREQTPLF 1771
Cdd:PHA02946   135 NSVDEEGCGPL-LACTDPSERVFKKIMSIGFEARIVDKFGKNHIhrHLMSDNPKASTISWMMKLGISPSKPDHDGNTPLH 213

                          170
                   ....*....|....*..
gi 1191447807 1772 LAAREGA--VEVAQLLL 1786
Cdd:PHA02946   214 IVCSKTVknVDIINLLL 230
Ank_5 pfam13857
Ankyrin repeats (many copies);
1685-1738 5.21e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 42.72  E-value: 5.21e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1191447807 1685 LLRSRQTAVDARTEDGTTPLMLAARLAVEDLVEELIAAQADVGARDKWGKTALH 1738
Cdd:pfam13857    1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALD 54
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 474-510 5.69e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 5.69e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1191447807  474 DHNECLSQ-PCHPGSTCLDLLATFHCLCPPGLEGQLCE 510
Cdd:cd00054      1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
514-548 5.83e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 5.83e-05
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1191447807   514 NECASA-PCLNHADCHDLLNGFQCICLPGFS-GTRCE 548
Cdd:smart00179    3 DECASGnPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 1635-1802 1.13e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 46.88  E-value: 1.13e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447807 1635 TPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLrsrqtavdartEDGTTPLMLAARLAVED 1714
Cdd:PHA02874    37 TPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLI-----------DNGVDTSILPIPCIEKD 105

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447807 1715 LVEELIAAQADVGARDKWGKTALHWAAAVNNARAARSLLQAGADKDAQDNREQTPLFLAAREGAVEVAQLLLGLGAAREL 1794
Cdd:PHA02874   106 MIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANV 185


                   ....*...
gi 1191447807 1795 RDQAGLAP 1802
Cdd:PHA02874   186 KDNNGESP 193
EGF_CA pfam07645
Calcium-binding EGF domain;
313-345 1.25e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 40.68  E-value: 1.25e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1191447807  313 DVDECETqGPPHCRNGGTCQNSAGSFHCVCVSG 345
Cdd:pfam07645    1 DVDECAT-GTHNCPANTVCVNTIGSFECRCPDG 32
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1167-1203 1.43e-04

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 40.59  E-value: 1.43e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1191447807 1167 PRCQKPGakgCEGRSGDGACDAGCSGPGGNWDGGDCS 1203
Cdd:pfam00066    2 PNCPYPY---CWDKFGNGVCDEECNNAECLWDGGDCS 35
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 971-1001 1.57e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 40.44  E-value: 1.57e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1191447807  971 CQSQPCHNHGTCTPKPGGFHCACPPGFVGLR 1001
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 1633-1664 1.58e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 40.74  E-value: 1.58e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1191447807 1633 GETPLHLAA-RFSRPTAARRLLEAGANPNQPDR 1664
Cdd:pfam00023    2 GNTPLHLAAgRRGNLEIVKLLLSKGADVNARDK 34
EGF_CA smart00179
Calcium-binding EGF-like domain;
768-802 2.03e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 2.03e-04
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1191447807   768 DYCVSA-PCFNGGTCVNRPGTFSCLCAMGFQ-GPRCE 802
Cdd:smart00179    3 DECASGnPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 1164-1202 2.16e-04

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 40.39  E-value: 2.16e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1191447807  1164 SPGPRCQkpgAKGCEGRSGDGACDAGCSGPGGNWDGGDC 1202
Cdd:smart00004    3 DPWSRCE---DAQCWDKFGDGVCDEECNNAECLWDGGDC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 930-964 2.82e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 2.82e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1191447807  930 VNPCESR-PCQNGATCMAQPSGYLCQCAPGYDGQNC 964
Cdd:cd00054      2 IDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 1636-1818 2.88e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 45.64  E-value: 2.88e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447807 1636 PLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLRS-------------------------RQ 1690
Cdd:PHA02878    40 PLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMIRSinkcsvfytlvaikdafnnrnveifKI 119

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447807 1691 TAVDARTEDGTTPLMLAARLAVEDLVEE-----LIAAQADVGARDK-WGKTALHWAAAVNNARAARSLLQAGADKDAQDN 1764
Cdd:PHA02878   120 ILTNRYKNIQTIDLVYIDKKSKDDIIEAeitklLLSYGADINMKDRhKGNTALHYATENKDQRLTELLLSYGANVNIPDK 199

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1191447807 1765 REQTPLFLAAREGAVEVAQLLLGLGAARELRDQAGLAPADVAHQR-NHWDLLTLL 1818
Cdd:PHA02878   200 TNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISVGYcKDYDILKLL 254
EGF_CA smart00179
Calcium-binding EGF-like domain;
969-1003 3.39e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 3.39e-04
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1191447807   969 DACQS-QPCHNHGTCTPKPGGFHCACPPGFV-GLRCE 1003
Cdd:smart00179    3 DECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
431-465 4.00e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 39.53  E-value: 4.00e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1191447807  431 DLDECLmaqQGPSPCEHGGSCLNTPGSFNCLCPPG 465
Cdd:pfam07645    1 DVDECA---TGTHNCPANTVCVNTIGSFECRCPDG 32
NOD pfam06816
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ...
 1294-1343 4.50e-04

NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. Role of NOD domain remains to be elucidated.


Pssm-ID: 462014  Cd Length: 56  Bit Score: 39.80  E-value: 4.50e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1191447807 1294 PSLAL----LVVLSPP-ALDQQLFALARVLSLTLRVGLWVRKDRDGRDMVYPYPG 1343
Cdd:pfam06816    2 EKLAEgvlvIVVLMDPeELLNNSVQFLRELSTVLRTNVRFKKDENGNPMIYPWYG 56
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1719-1787 4.57e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 45.27  E-value: 4.57e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1191447807 1719 LIAAQADVGARDKWGKTALHWAAAVNNARAARSLLQAGADKDAQDNREQTPLFLAAREGAVEVAQLLLG 1787
Cdd:PTZ00322   101 LLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSR 169
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 770-800 6.09e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.90  E-value: 6.09e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1191447807  770 CVSAPCFNGGTCVNRPGTFSCLCAMGFQGPR 800
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
Ank_5 pfam13857
Ankyrin repeats (many copies);
1752-1806 6.27e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 39.64  E-value: 6.27e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1191447807 1752 LLQAG-ADKDAQDNREQTPLFLAAREGAVEVAQLLLGLGAARELRDQAGLAPADVA 1806
Cdd:pfam13857    1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 442-470 6.82e-04

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 39.00  E-value: 6.82e-04
                           10        20
                   ....*....|....*....|....*....
gi 1191447807  442 PSPCEHGGSCLNTPGSFNCLCPPGYTGSR 470
Cdd:cd00053      5 SNPCSNGGTCVNTPGSYRCVCPPGYTGDR 33
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 442-470 7.86e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.52  E-value: 7.86e-04
                           10        20
                   ....*....|....*....|....*....
gi 1191447807  442 PSPCEHGGSCLNTPGSFNCLCPPGYTGSR 470
Cdd:pfam00008    3 PNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 1633-1660 8.43e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 38.39  E-value: 8.43e-04
                           10        20
                   ....*....|....*....|....*...
gi 1191447807 1633 GETPLHLAARFSRPTAARRLLEAGANPN 1660
Cdd:pfam13606    2 GNTPLHLAARNGRLEIVKLLLENGADIN 29
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 735-764 8.57e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.77  E-value: 8.57e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 1191447807  735 GPCLNGGSCNPSPGGYYCTCPPSHTGPQCQ 764
Cdd:cd00054      9 NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
588-624 8.88e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 8.88e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1191447807   588 EVDECLS-DPCPVGASCLDLPGAFFCLCPSGFT-GQLCE 624
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 1632-1786 1.05e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 44.10  E-value: 1.05e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447807 1632 TGETPLHLAARFSRPT---AARRLLEAGANPNQPDR-----------AGRTPLHAAVAADAREVCQLLLrSRQTAVDART 1697
Cdd:cd21882     25 TGKTCLHKAALNLNDGvneAIMLLLEAAPDSGNPKElvnapctdefyQGQTALHIAIENRNLNLVRLLV-ENGADVSARA 103

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447807 1698 ED-------------GTTPLMLAARLAVEDLVEELI---AAQADVGARDKWGKTALHWAAAVNNARAARS---------L 1752
Cdd:cd21882    104 TGrffrkspgnlfyfGELPLSLAACTNQEEIVRLLLengAQPAALEAQDSLGNTVLHALVLQADNTPENSafvcqmynlL 183

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 1191447807 1753 LQAGADKDAQDNREQ-------TPLFLAAREGAVEVAQLLL 1786
Cdd:cd21882    184 LSYGAHLDPTQQLEEipnhqglTPLKLAAVEGKIVMFQHIL 224
EGF_CA smart00179
Calcium-binding EGF-like domain;
474-510 1.09e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.09e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1191447807   474 DHNECLS-QPCHPGSTCLDLLATFHCLCPPGLE-GQLCE 510
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
TRPV1-4 cd22193
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are ...
 1633-1710 1.19e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are thermo-sensing channels that function directly in temperature-sensing and nociception; they share substantial structural and functional properties. Transient Receptor Potential (TRP) ion channels activated by temperature (thermo TRPs) are important molecular players in acute, inflammatory, and chronic pain states. So far, 11 TRP channels in mammalian cells have been identified as thermosensitive TRP (thermo-TRP) channels. TRPV1-4 channels are activated by different heat temperatures, for example, TRPV1 and TRPV2 are activated by high temperatures (>43C and >55C, respectively). TRPV1-4 belong to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411977 [Multi-domain]  Cd Length: 607  Bit Score: 44.02  E-value: 1.19e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447807 1633 GETPLHLAARFSRPTAARRLLEagaNPNQP------DRAGRTPLHA--AVAADAREVCQ--------LLLRSRQTAVDAR 1696
Cdd:cd22193    123 GELPLSLAACTNQPDIVQYLLE---NEHQPadieaqDSRGNTVLHAlvTVADNTKENTKfvtrmydmILIRGAKLCPTVE 199

                           90
                   ....*....|....*....
gi 1191447807 1697 TE-----DGTTPLMLAARL 1710
Cdd:cd22193    200 LEeirnnDGLTPLQLAAKM 218
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 698-725 1.25e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 1.25e-03
                           10        20
                   ....*....|....*....|....*...
gi 1191447807  698 PCAHGGTCYPQPSGYNCTCPTGYTGPTC 725
Cdd:cd00054     10 PCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 898-927 1.49e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 1.49e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1191447807  898 SLCHNGGLCVDSGPSYFCHCPPGFQGSLCQ 927
Cdd:cd00054      9 NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 1633-1775 1.74e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 43.03  E-value: 1.74e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447807 1633 GETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLrSRQTAVDARTEDGTTPL---MLAAR 1709
Cdd:PHA02874   157 GCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLI-DHGNHIMNKCKNGFTPLhnaIIHNR 235

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1191447807 1710 LAVedlveELIAAQADVGARDKWGKTALHWA-AAVNNARAARSLLQAGADKDAQDNREQTPLFLAAR 1775
Cdd:PHA02874   236 SAI-----ELLINNASINDQDIDGSTPLHHAiNPPCDIDIIDILLYHKADISIKDNKGENPIDTAFK 297
NODP pfam07684
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ...
 1378-1419 1.93e-03

NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. The role of the NOD and NODP domains remains to be elucidated.


Pssm-ID: 462229  Cd Length: 59  Bit Score: 38.41  E-value: 1.93e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1191447807 1378 AGFVVVMGVDLSRCGPDHpaSRCPWDPGLLLRFLAAMAAVGA 1419
Cdd:pfam07684    2 IGSVVYLEIDNRKCSQSS--DECFSTAQSAADFLAALAAKGG 41
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 972-1001 2.13e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 37.46  E-value: 2.13e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1191447807  972 QSQPCHNHGTCTPKPGGFHCACPPGFVGLR 1001
Cdd:cd00053      4 ASNPCSNGGTCVNTPGSYRCVCPPGYTGDR 33
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 933-963 2.51e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.98  E-value: 2.51e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1191447807  933 CESRPCQNGATCMAQPSGYLCQCAPGYDGQN 963
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 732-762 2.66e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.98  E-value: 2.66e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1191447807  732 CHSGPCLNGGSCNPSPGGYYCTCPPSHTGPQ 762
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 1699-1731 2.78e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 37.27  E-value: 2.78e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1191447807 1699 DGTTPLMLAA-RLAVEDLVEELIAAQADVGARDK 1731
Cdd:pfam00023    1 DGNTPLHLAAgRRGNLEIVKLLLSKGADVNARDK 34
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 1652-1790 2.83e-03

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 42.93  E-value: 2.83e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447807 1652 LLEAGANPNQPDRAGRTPLHAAvAADAREVCQLLLRSRQTAVDARTEDGTTPLMLAARLAVEDLVEEL--IAAQADVGAr 1729
Cdd:PLN03192   544 LLKAKLDPDIGDSKGRTPLHIA-ASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILyhFASISDPHA- 621

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1191447807 1730 dkwGKTALHWAAAVNNARAARSLLQAGADKDAQDNREQTPLFLAAREGAVEVAQLLLGLGA 1790
Cdd:PLN03192   622 ---AGDLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGA 679
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 1634-1806 3.09e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 42.26  E-value: 3.09e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447807 1634 ETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLRSRQTAvDARTEDGTTPLMLAARLAVE 1713
Cdd:PHA02874   125 KTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYA-NVKDNNGESPLHNAAEYGDY 203

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447807 1714 DLVEELIAAQADVGARDKWGKTALHwaAAVNNARAARSLLQAGADKDAQDNREQTPLFLAAR-EGAVEVAQLLLGLGAAR 1792
Cdd:PHA02874   204 ACIKLLIDHGNHIMNKCKNGFTPLH--NAIIHNRSAIELLINNASINDQDIDGSTPLHHAINpPCDIDIIDILLYHKADI 281

                          170
                   ....*....|....
gi 1191447807 1793 ELRDQAGLAPADVA 1806
Cdd:PHA02874   282 SIKDNKGENPIDTA 295
EGF_CA smart00179
Calcium-binding EGF-like domain;
930-964 3.49e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 3.49e-03
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1191447807   930 VNPCESR-PCQNGATCMAQPSGYLCQCAPGY-DGQNC 964
Cdd:smart00179    2 IDECASGnPCQNGGTCVNTVGSYRCECPPGYtDGRNC 38
Ank_4 pfam13637
Ankyrin repeats (many copies);
1735-1786 3.54e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 37.25  E-value: 3.54e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1191447807 1735 TALHWAAAVNNARAARSLLQAGADKDAQDNREQTPLFLAAREGAVEVAQLLL 1786
Cdd:pfam13637    3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 363-389 3.75e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 3.75e-03
                           10        20
                   ....*....|....*....|....*..
gi 1191447807  363 CAPGSTCIDRVGSFSCLCPPGRTGLLC 389
Cdd:cd00054     11 CQNGGTCVNTVGSYRCSCPPGYTGRNC 37
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 1632-1761 3.97e-03

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 42.16  E-value: 3.97e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447807 1632 TGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLrsrQTAVDARTEDGTTPLMLAARLA 1711
Cdd:PLN03192   557 KGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILY---HFASISDPHAAGDLLCTAAKRN 633

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1191447807 1712 VEDLVEELIAAQADVGARDKWGKTALHWAAAVNNARAARSLLQAGADKDA 1761
Cdd:PLN03192   634 DLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDK 683
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 812-841 4.10e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 4.10e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1191447807  812 SPCRNRATCQDSPQGPRCLCPTGYTGGSCQ 841
Cdd:cd00054      9 NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 1652-1773 4.83e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 41.49  E-value: 4.83e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447807 1652 LLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLRSRqTAVDARTEDGTTPLMLAARLAVEDLVEELIAAQADVGARDK 1731
Cdd:PHA02874   110 ILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYG-ADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDN 188

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1191447807 1732 WGKTALHWAAAVNNARAARSLLQAGADKDAQDNREQTPLFLA 1773
Cdd:PHA02874   189 NGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNA 230
COG3903 COG3903
Predicted ATPase [General function prediction only];
1663-1847 4.99e-03

Predicted ATPase [General function prediction only];


Pssm-ID: 443109 [Multi-domain]  Cd Length: 933  Bit Score: 41.93  E-value: 4.99e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447807 1663 DRAGRTPLHAAVAADAREVCQLLLRSRQTAVDARTEDGTTPLMLAARLAVEDLVEELIAAQADVGARDKWGKTALHWAAA 1742
Cdd:COG3903      3 AAAAAAAAAAAAALALLALAAAAAAAAAAAALAAALEALRAALALLLLLLAALALALAALALLLAAAALLLRLLLLLLAA 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447807 1743 VNNARAARSLLQAGADKDAQDNREQTPLFLAAREGAVEVAQLLLGLGAARELRDQAGLAPADVAHQRNHWDLLTLLEGAG 1822
Cdd:COG3903     83 RLLARLAAAAAAALARAAAAALALLLRLRLAARRLLLARALAAAALAAAAAAAAAAAAAPAPPPPAPPPPAPLAALARRA 162

                          170       180
                   ....*....|....*....|....*
gi 1191447807 1823 PPEARhkatpgREAGPFPRARTVSV 1847
Cdd:COG3903    163 AALAA------AARALLSAARLVTL 181
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 809-837 6.77e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.82  E-value: 6.77e-03
                           10        20
                   ....*....|....*....|....*....
gi 1191447807  809 CADSPCRNRATCQDSPQGPRCLCPTGYTG 837
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
TRPV3 cd22194
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a ...
 1618-1710 7.12e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a temperature-sensitive Transient Receptor Potential (TRP) ion channel that is activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. TRPV3 function is regulated by physiological factors such as extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. It is expressed in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice have abnormal hair morphogenesis and compromised skin barrier function. It may play roles in inflammatory skin disorders, such as itch and pain sensation. TRPV3 is also expressed by many neuronal and non-neuronal tissues, showing that TRPV3 might play roles in other unknown cellular and physiological functions. TRPV3 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411978 [Multi-domain]  Cd Length: 680  Bit Score: 41.28  E-value: 7.12e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447807 1618 LLDGGACPQAHTVGT-------------GETPLHLAARFSRPTAARRLLEAGANP-NQPDRAGRTPLHAAV-AADAREVC 1682
Cdd:cd22194    160 LIAKGADVNAHAKGVffnpkykhegfyfGETPLALAACTNQPEIVQLLMEKESTDiTSQDSRGNTVLHALVtVAEDSKTQ 239

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1191447807 1683 ---------QLLLRSRQTAVDA-RTEDGTTPLMLAARL 1710
Cdd:cd22194    240 ndfvkrmydMILLKSENKNLETiRNNEGLTPLQLAAKM 277
PHA03095 PHA03095
ankyrin-like protein; Provisional
 1704-1799 9.29e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 40.78  E-value: 9.29e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447807 1704 LMLAARLAVEDlVEELIAAQADVGARDKWGKTALHWAAAVNNARAA---RSLLQAGADKDAQDNREQTPLFLAAREGAVE 1780
Cdd:PHA03095    19 LLNASNVTVEE-VRRLLAAGADVNFRGEYGKTPLHLYLHYSSEKVKdivRLLLEAGADVNAPERCGFTPLHLYLYNATTL 97

                           90       100
                   ....*....|....*....|
gi 1191447807 1781 -VAQLLLGLGAARELRDQAG 1799
Cdd:PHA03095    98 dVIKLLIKAGADVNAKDKVG 117
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 279-307 9.37e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.44  E-value: 9.37e-03
                           10        20
                   ....*....|....*....|....*....
gi 1191447807  279 CVSHQCQNGGTCQDGLDTYTCLCPETWTG 307
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1046-1083 9.57e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 9.57e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1191447807 1046 IDPCHSQ-PCFHGGTCEATAGSplgFICHCPKGFEGPTC 1083
Cdd:cd00054      2 IDECASGnPCQNGGTCVNTVGS---YRCSCPPGYTGRNC 37
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH