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Conserved domains on  [gi|119390043]
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Protein Classification

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List of domain hits

Name Accession Description Interval E-value
TPP1 pfam10341
Shelterin complex subunit, TPP1/ACD. TPP1 is a component of the telomerase holoenzyme, ...
8-106 1.82e-27

Shelterin complex subunit, TPP1/ACD. TPP1 is a component of the telomerase holoenzyme, involved in telomere replication. It has been demonstrated that TPP1 dimerizes and binds to DNA and RNA. Furthermore, TPP1 stimulates the dissociation of RNA/DNA hetero-duplexes. Yeast telomerase protein TPP1 (Est3 in yeast) is a novel type of GTPase. The key residues in yeast EST3 are an Asp at residue 86 and the Arg at residue 110. The Asp is totally conserved in the family, whereas the Arg is not so well conserved. The N-terminal of TPP1 is likely to be the binding surface for TINF2, whereas the C-terminus probably binds to POT1, thereby tethering POT1 to the shelterin complex. The complex bound to telomeric DNA increases the activity and processivity of the human telomerase core enzyme, thus helping to maintain the length of the telomeres. This domain is conserved from fungi to mammals, hence family Telomere_Pot1 has been merged into the family. The human shelterin complex includes six proteins: telomere repeat binding factor 1 (TRF1), TRF2, repressor/activator protein 1 (RAP1), TRF1-interacting nuclear protein 2 (TIN2), TIN2-interacting protein 1 (TPP1) and protection of telomeres 1 (POT1).


:

Pssm-ID: 370991  Cd Length: 105  Bit Score: 98.54  E-value: 1.82e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119390043    8 PWIRELILGSETPSSPR--------AGQLLEVLQdaeaavagpsHAPDTSDVGATLLVSDGTHSVRCLVTREALDTSDWE 79
Cdd:pfam10341   1 PWIEKLVLGAIKLSLDYptlptnpsPAQLLKVVK----------FAQSTSNPAITALLSDSTHQILAIFTREAVSNFERE 70
                          90       100
                  ....*....|....*....|....*..
gi 119390043   80 EKEFGFRGTEGRLLLLQDCGVHVQVAE 106
Cdd:pfam10341  71 EKSRITSGTKNCLILIKDASLVFQTVS 97
 
Name Accession Description Interval E-value
TPP1 pfam10341
Shelterin complex subunit, TPP1/ACD. TPP1 is a component of the telomerase holoenzyme, ...
8-106 1.82e-27

Shelterin complex subunit, TPP1/ACD. TPP1 is a component of the telomerase holoenzyme, involved in telomere replication. It has been demonstrated that TPP1 dimerizes and binds to DNA and RNA. Furthermore, TPP1 stimulates the dissociation of RNA/DNA hetero-duplexes. Yeast telomerase protein TPP1 (Est3 in yeast) is a novel type of GTPase. The key residues in yeast EST3 are an Asp at residue 86 and the Arg at residue 110. The Asp is totally conserved in the family, whereas the Arg is not so well conserved. The N-terminal of TPP1 is likely to be the binding surface for TINF2, whereas the C-terminus probably binds to POT1, thereby tethering POT1 to the shelterin complex. The complex bound to telomeric DNA increases the activity and processivity of the human telomerase core enzyme, thus helping to maintain the length of the telomeres. This domain is conserved from fungi to mammals, hence family Telomere_Pot1 has been merged into the family. The human shelterin complex includes six proteins: telomere repeat binding factor 1 (TRF1), TRF2, repressor/activator protein 1 (RAP1), TRF1-interacting nuclear protein 2 (TIN2), TIN2-interacting protein 1 (TPP1) and protection of telomeres 1 (POT1).


Pssm-ID: 370991  Cd Length: 105  Bit Score: 98.54  E-value: 1.82e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119390043    8 PWIRELILGSETPSSPR--------AGQLLEVLQdaeaavagpsHAPDTSDVGATLLVSDGTHSVRCLVTREALDTSDWE 79
Cdd:pfam10341   1 PWIEKLVLGAIKLSLDYptlptnpsPAQLLKVVK----------FAQSTSNPAITALLSDSTHQILAIFTREAVSNFERE 70
                          90       100
                  ....*....|....*....|....*..
gi 119390043   80 EKEFGFRGTEGRLLLLQDCGVHVQVAE 106
Cdd:pfam10341  71 EKSRITSGTKNCLILIKDASLVFQTVS 97
 
Name Accession Description Interval E-value
TPP1 pfam10341
Shelterin complex subunit, TPP1/ACD. TPP1 is a component of the telomerase holoenzyme, ...
8-106 1.82e-27

Shelterin complex subunit, TPP1/ACD. TPP1 is a component of the telomerase holoenzyme, involved in telomere replication. It has been demonstrated that TPP1 dimerizes and binds to DNA and RNA. Furthermore, TPP1 stimulates the dissociation of RNA/DNA hetero-duplexes. Yeast telomerase protein TPP1 (Est3 in yeast) is a novel type of GTPase. The key residues in yeast EST3 are an Asp at residue 86 and the Arg at residue 110. The Asp is totally conserved in the family, whereas the Arg is not so well conserved. The N-terminal of TPP1 is likely to be the binding surface for TINF2, whereas the C-terminus probably binds to POT1, thereby tethering POT1 to the shelterin complex. The complex bound to telomeric DNA increases the activity and processivity of the human telomerase core enzyme, thus helping to maintain the length of the telomeres. This domain is conserved from fungi to mammals, hence family Telomere_Pot1 has been merged into the family. The human shelterin complex includes six proteins: telomere repeat binding factor 1 (TRF1), TRF2, repressor/activator protein 1 (RAP1), TRF1-interacting nuclear protein 2 (TIN2), TIN2-interacting protein 1 (TPP1) and protection of telomeres 1 (POT1).


Pssm-ID: 370991  Cd Length: 105  Bit Score: 98.54  E-value: 1.82e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119390043    8 PWIRELILGSETPSSPR--------AGQLLEVLQdaeaavagpsHAPDTSDVGATLLVSDGTHSVRCLVTREALDTSDWE 79
Cdd:pfam10341   1 PWIEKLVLGAIKLSLDYptlptnpsPAQLLKVVK----------FAQSTSNPAITALLSDSTHQILAIFTREAVSNFERE 70
                          90       100
                  ....*....|....*....|....*..
gi 119390043   80 EKEFGFRGTEGRLLLLQDCGVHVQVAE 106
Cdd:pfam10341  71 EKSRITSGTKNCLILIKDASLVFQTVS 97
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.19
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
  • Marchler-Bauer A et al. (2015), "CDD: NCBI's conserved domain database.", Nucleic Acids Res.43(D)222-6.
  • Marchler-Bauer A et al. (2011), "CDD: a Conserved Domain Database for the functional annotation of proteins.", Nucleic Acids Res.39(D)225-9.
  • Marchler-Bauer A, Bryant SH (2004), "CD-Search: protein domain annotations on the fly.", Nucleic Acids Res.32(W)327-331.
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