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Conserved domains on  [gi|120140|sp|P12799|]
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RecName: Full=Fibrinogen gamma-B chain; Short=Gamma'; Flags: Precursor

Protein Classification

Fib_alpha and FReD domain-containing protein( domain architecture ID 11179727)

Fib_alpha and FReD domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Fibrinogen_C pfam00147
Fibrinogen beta and gamma chains, C-terminal globular domain;
173-414 1.13e-122

Fibrinogen beta and gamma chains, C-terminal globular domain;


:

Pssm-ID: 395095 [Multi-domain]  Cd Length: 221  Bit Score: 355.68  E-value: 1.13e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120140     173 TGRDCQDVANKGAKESGLYFIRPLKAKQ-FLVYCEIDGSGNGWTVFQKRLDGSLDFKKNWIQYKEGFGHLSPTgtgntEF 251
Cdd:pfam00147   1 FGRDCSDVYNKGAKTSGLYTIRPDGATKpFEVYCDMETDGGGWTVFQRRLDGSTNFKRNWKDYKAGFGNLSPG-----EF 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120140     252 WLGNEKIHLISTQSsiPYVLRIQLEDWNGRTSTADYASFKVTGENDKYRLTYAYFIGgDAGDAFDGydfgddsSDKFFTS 331
Cdd:pfam00147  76 WLGNDKIHLLTKQG--PYVLRIDLEDWNGETVFALYDSFKVTNENDKYRLHVENYIG-DAGDALDT-------AGRSMTY 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120140     332 HNGMQFSTWDSDNDKYDGNCAEQVGIGWWMNKCHAGHLNGVYYQGGTYSKtstpngyDNGIIWATWKSRWYSMKKTTMKI 411
Cdd:pfam00147 146 HNGMQFSTWDRDNDSPDGNCALSYGGGWWYNNCHAANLNGVYYYGGTYSK-------QNGIIWATWKGRWYSMKKAEMKI 218

                  ...
gi 120140     412 IPL 414
Cdd:pfam00147 219 RPL 221
Fib_alpha pfam08702
Fibrinogen alpha/beta chain family; Fibrinogen is a protein involved in platelet aggregation ...
28-170 1.90e-68

Fibrinogen alpha/beta chain family; Fibrinogen is a protein involved in platelet aggregation and is essential for the coagulation of blood. This domain forms part of the central coiled coiled region of the protein which is formed from two sets of three non-identical chains (alpha, beta and gamma).


:

Pssm-ID: 430163  Cd Length: 143  Bit Score: 213.94  E-value: 1.90e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120140      28 TRDNCCILDERFGSYCPTTCGIADFLNNYQTSVDKDLRTLEGILYQVENKTSEARELVKAIQISYNPDQPSKPNNiESAT 107
Cdd:pfam08702   1 DKGGCCHADEDFGVLCPTGCGIQDLLLKYERDVDKDLQKLENLLDQISNSTSSADELVKQIKDSLRERQKSSPDN-DNVY 79
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 120140     108 KNSKSMME-EIMKYETLISTHESTIRFLQEVYNSNSQKIVNLRDKVVQLEANCQEPCQDTVKIH 170
Cdd:pfam08702  80 NKSSSMLEeRIAYIKETVDTQESNIRVLQNILDSNRQKIQRLEQDIDQLERKCKEPCKDSVEIQ 143
 
Name Accession Description Interval E-value
Fibrinogen_C pfam00147
Fibrinogen beta and gamma chains, C-terminal globular domain;
173-414 1.13e-122

Fibrinogen beta and gamma chains, C-terminal globular domain;


Pssm-ID: 395095 [Multi-domain]  Cd Length: 221  Bit Score: 355.68  E-value: 1.13e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120140     173 TGRDCQDVANKGAKESGLYFIRPLKAKQ-FLVYCEIDGSGNGWTVFQKRLDGSLDFKKNWIQYKEGFGHLSPTgtgntEF 251
Cdd:pfam00147   1 FGRDCSDVYNKGAKTSGLYTIRPDGATKpFEVYCDMETDGGGWTVFQRRLDGSTNFKRNWKDYKAGFGNLSPG-----EF 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120140     252 WLGNEKIHLISTQSsiPYVLRIQLEDWNGRTSTADYASFKVTGENDKYRLTYAYFIGgDAGDAFDGydfgddsSDKFFTS 331
Cdd:pfam00147  76 WLGNDKIHLLTKQG--PYVLRIDLEDWNGETVFALYDSFKVTNENDKYRLHVENYIG-DAGDALDT-------AGRSMTY 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120140     332 HNGMQFSTWDSDNDKYDGNCAEQVGIGWWMNKCHAGHLNGVYYQGGTYSKtstpngyDNGIIWATWKSRWYSMKKTTMKI 411
Cdd:pfam00147 146 HNGMQFSTWDRDNDSPDGNCALSYGGGWWYNNCHAANLNGVYYYGGTYSK-------QNGIIWATWKGRWYSMKKAEMKI 218

                  ...
gi 120140     412 IPL 414
Cdd:pfam00147 219 RPL 221
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
173-414 2.10e-108

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


Pssm-ID: 238040  Cd Length: 215  Bit Score: 319.19  E-value: 2.10e-108
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120140   173 TGRDCQDVANKGAKESGLYFIRPLKAKQ-FLVYCEIDGSGNGWTVFQKRLDGSLDFKKNWIQYKEGFGHLsptgtgNTEF 251
Cdd:cd00087   2 LPRDCSEVLQRGGRTSGVYTIQPPGSNEpFQVYCDMDTDGGGWTVIQRRGDGSVDFYRSWKEYKDGFGNL------DGEF 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120140   252 WLGNEKIHLISTQSsiPYVLRIQLEDWNGRTSTADYASFKVTGENDKYRLTYAYFiGGDAGDAFdgydfgddssdkffTS 331
Cdd:cd00087  76 WLGLEKIHLLTSQG--PYELRIDLEDWEGNTAYAEYDSFKVGSESEGYRLTLGGY-SGTAGDAL--------------SY 138
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120140   332 HNGMQFSTWDSDNDKYDGNCAEQVGIGWWMNKCHAGHLNGVYYQGGtysktsTPNGYDNGIIWATWKSRWYSMKKTTMKI 411
Cdd:cd00087 139 HNGMKFSTFDRDNDGASGNCAESYSGGWWYNSCHASNLNGRYYSGG------HRNEYDNGINWATWKGSTYSLKFTEMKI 212

                ...
gi 120140   412 IPL 414
Cdd:cd00087 213 RPK 215
FBG smart00186
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ...
173-414 7.88e-107

Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.


Pssm-ID: 214548 [Multi-domain]  Cd Length: 212  Bit Score: 314.99  E-value: 7.88e-107
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120140      173 TGRDCQDVANKGAKESGLYFIRPLKAKQ-FLVYCEIDGSGNGWTVFQKRLDGSLDFKKNWIQYKEGFGHLsptgtgNTEF 251
Cdd:smart00186   1 LPRDCSDVLQNGGKTSGLYTIYPDGSSRpLKVYCDMETDGGGWTVIQRRMDGSVDFYRDWKDYKEGFGNL------AGEF 74
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120140      252 WLGNEKIHLISTQSsiPYVLRIQLEDWNGRTSTADYASFKVTGENDKYRLtyayFIGGDAGDAFDGYdfgddssdkfFTS 331
Cdd:smart00186  75 WLGNENIHLLTSQG--KYELRIDLEDWEGNTAYALYDSFKVADEADGYRL----HIGGYSGTAGDAS----------LTY 138
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120140      332 HNGMQFSTWDSDNDKYDGNCAEQVGIGWWMNKCHAGHLNGVYYQggtysktstPNGYDNGIIWATWKSRWYSMKKTTMKI 411
Cdd:smart00186 139 HNGMQFSTYDRDNDKYSGNCAEEYGGGWWYNNCHAANLNGRYYP---------NNNYDNGINWATWKGSWYSLKFTEMKI 209

                   ...
gi 120140      412 IPL 414
Cdd:smart00186 210 RPL 212
Fib_alpha pfam08702
Fibrinogen alpha/beta chain family; Fibrinogen is a protein involved in platelet aggregation ...
28-170 1.90e-68

Fibrinogen alpha/beta chain family; Fibrinogen is a protein involved in platelet aggregation and is essential for the coagulation of blood. This domain forms part of the central coiled coiled region of the protein which is formed from two sets of three non-identical chains (alpha, beta and gamma).


Pssm-ID: 430163  Cd Length: 143  Bit Score: 213.94  E-value: 1.90e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120140      28 TRDNCCILDERFGSYCPTTCGIADFLNNYQTSVDKDLRTLEGILYQVENKTSEARELVKAIQISYNPDQPSKPNNiESAT 107
Cdd:pfam08702   1 DKGGCCHADEDFGVLCPTGCGIQDLLLKYERDVDKDLQKLENLLDQISNSTSSADELVKQIKDSLRERQKSSPDN-DNVY 79
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 120140     108 KNSKSMME-EIMKYETLISTHESTIRFLQEVYNSNSQKIVNLRDKVVQLEANCQEPCQDTVKIH 170
Cdd:pfam08702  80 NKSSSMLEeRIAYIKETVDTQESNIRVLQNILDSNRQKIQRLEQDIDQLERKCKEPCKDSVEIQ 143
 
Name Accession Description Interval E-value
Fibrinogen_C pfam00147
Fibrinogen beta and gamma chains, C-terminal globular domain;
173-414 1.13e-122

Fibrinogen beta and gamma chains, C-terminal globular domain;


Pssm-ID: 395095 [Multi-domain]  Cd Length: 221  Bit Score: 355.68  E-value: 1.13e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120140     173 TGRDCQDVANKGAKESGLYFIRPLKAKQ-FLVYCEIDGSGNGWTVFQKRLDGSLDFKKNWIQYKEGFGHLSPTgtgntEF 251
Cdd:pfam00147   1 FGRDCSDVYNKGAKTSGLYTIRPDGATKpFEVYCDMETDGGGWTVFQRRLDGSTNFKRNWKDYKAGFGNLSPG-----EF 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120140     252 WLGNEKIHLISTQSsiPYVLRIQLEDWNGRTSTADYASFKVTGENDKYRLTYAYFIGgDAGDAFDGydfgddsSDKFFTS 331
Cdd:pfam00147  76 WLGNDKIHLLTKQG--PYVLRIDLEDWNGETVFALYDSFKVTNENDKYRLHVENYIG-DAGDALDT-------AGRSMTY 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120140     332 HNGMQFSTWDSDNDKYDGNCAEQVGIGWWMNKCHAGHLNGVYYQGGTYSKtstpngyDNGIIWATWKSRWYSMKKTTMKI 411
Cdd:pfam00147 146 HNGMQFSTWDRDNDSPDGNCALSYGGGWWYNNCHAANLNGVYYYGGTYSK-------QNGIIWATWKGRWYSMKKAEMKI 218

                  ...
gi 120140     412 IPL 414
Cdd:pfam00147 219 RPL 221
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
173-414 2.10e-108

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


Pssm-ID: 238040  Cd Length: 215  Bit Score: 319.19  E-value: 2.10e-108
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120140   173 TGRDCQDVANKGAKESGLYFIRPLKAKQ-FLVYCEIDGSGNGWTVFQKRLDGSLDFKKNWIQYKEGFGHLsptgtgNTEF 251
Cdd:cd00087   2 LPRDCSEVLQRGGRTSGVYTIQPPGSNEpFQVYCDMDTDGGGWTVIQRRGDGSVDFYRSWKEYKDGFGNL------DGEF 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120140   252 WLGNEKIHLISTQSsiPYVLRIQLEDWNGRTSTADYASFKVTGENDKYRLTYAYFiGGDAGDAFdgydfgddssdkffTS 331
Cdd:cd00087  76 WLGLEKIHLLTSQG--PYELRIDLEDWEGNTAYAEYDSFKVGSESEGYRLTLGGY-SGTAGDAL--------------SY 138
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120140   332 HNGMQFSTWDSDNDKYDGNCAEQVGIGWWMNKCHAGHLNGVYYQGGtysktsTPNGYDNGIIWATWKSRWYSMKKTTMKI 411
Cdd:cd00087 139 HNGMKFSTFDRDNDGASGNCAESYSGGWWYNSCHASNLNGRYYSGG------HRNEYDNGINWATWKGSTYSLKFTEMKI 212

                ...
gi 120140   412 IPL 414
Cdd:cd00087 213 RPK 215
FBG smart00186
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ...
173-414 7.88e-107

Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.


Pssm-ID: 214548 [Multi-domain]  Cd Length: 212  Bit Score: 314.99  E-value: 7.88e-107
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120140      173 TGRDCQDVANKGAKESGLYFIRPLKAKQ-FLVYCEIDGSGNGWTVFQKRLDGSLDFKKNWIQYKEGFGHLsptgtgNTEF 251
Cdd:smart00186   1 LPRDCSDVLQNGGKTSGLYTIYPDGSSRpLKVYCDMETDGGGWTVIQRRMDGSVDFYRDWKDYKEGFGNL------AGEF 74
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120140      252 WLGNEKIHLISTQSsiPYVLRIQLEDWNGRTSTADYASFKVTGENDKYRLtyayFIGGDAGDAFDGYdfgddssdkfFTS 331
Cdd:smart00186  75 WLGNENIHLLTSQG--KYELRIDLEDWEGNTAYALYDSFKVADEADGYRL----HIGGYSGTAGDAS----------LTY 138
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120140      332 HNGMQFSTWDSDNDKYDGNCAEQVGIGWWMNKCHAGHLNGVYYQggtysktstPNGYDNGIIWATWKSRWYSMKKTTMKI 411
Cdd:smart00186 139 HNGMQFSTYDRDNDKYSGNCAEEYGGGWWYNNCHAANLNGRYYP---------NNNYDNGINWATWKGSWYSLKFTEMKI 209

                   ...
gi 120140      412 IPL 414
Cdd:smart00186 210 RPL 212
Fib_alpha pfam08702
Fibrinogen alpha/beta chain family; Fibrinogen is a protein involved in platelet aggregation ...
28-170 1.90e-68

Fibrinogen alpha/beta chain family; Fibrinogen is a protein involved in platelet aggregation and is essential for the coagulation of blood. This domain forms part of the central coiled coiled region of the protein which is formed from two sets of three non-identical chains (alpha, beta and gamma).


Pssm-ID: 430163  Cd Length: 143  Bit Score: 213.94  E-value: 1.90e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120140      28 TRDNCCILDERFGSYCPTTCGIADFLNNYQTSVDKDLRTLEGILYQVENKTSEARELVKAIQISYNPDQPSKPNNiESAT 107
Cdd:pfam08702   1 DKGGCCHADEDFGVLCPTGCGIQDLLLKYERDVDKDLQKLENLLDQISNSTSSADELVKQIKDSLRERQKSSPDN-DNVY 79
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 120140     108 KNSKSMME-EIMKYETLISTHESTIRFLQEVYNSNSQKIVNLRDKVVQLEANCQEPCQDTVKIH 170
Cdd:pfam08702  80 NKSSSMLEeRIAYIKETVDTQESNIRVLQNILDSNRQKIQRLEQDIDQLERKCKEPCKDSVEIQ 143
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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