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Conserved domains on  [gi|1216936615|ref|XP_021662593|]
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calcium-binding protein KRP1 [Hevea brasiliensis]

Protein Classification

EF-hand domain-containing protein( domain architecture ID 10619601)

EF-hand (EFh) domain-containing protein may be involved in binding intracellular calcium and in calcium signal transduction

CATH:  1.10.238.10
Gene Ontology:  GO:0005509
PubMed:  2479149|10191494

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EF-hand_8 pfam13833
EF-hand domain pair;
93-146 1.01e-18

EF-hand domain pair;


:

Pssm-ID: 404678 [Multi-domain]  Cd Length: 54  Bit Score: 75.04  E-value: 1.01e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1216936615  93 EKGVITFESLKRNSALLGLQDLSDDDLRCMLKEGDFDGDGALNQMEFCVLMFRL 146
Cdd:pfam13833   1 EKGVITREELKRALALLGLKDLSEDEVDILFREFDTDGDGYISFDEFCVLLERR 54
 
Name Accession Description Interval E-value
EF-hand_8 pfam13833
EF-hand domain pair;
93-146 1.01e-18

EF-hand domain pair;


Pssm-ID: 404678 [Multi-domain]  Cd Length: 54  Bit Score: 75.04  E-value: 1.01e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1216936615  93 EKGVITFESLKRNSALLGLQDLSDDDLRCMLKEGDFDGDGALNQMEFCVLMFRL 146
Cdd:pfam13833   1 EKGVITREELKRALALLGLKDLSEDEVDILFREFDTDGDGYISFDEFCVLLERR 54
PTZ00183 PTZ00183
centrin; Provisional
 61-143 1.04e-11

centrin; Provisional


Pssm-ID: 185503 [Multi-domain]  Cd Length: 158  Bit Score: 59.70  E-value: 1.04e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1216936615  61 NFYDYLPVMAHKLGGDGLIGELCNGFNLLMDSEKGVITFESLKRNSALLGlQDLSDDDLRCMLKEGDFDGDGALNQMEFC 140
Cdd:PTZ00183   71 DFEEFLDIMTKKLGERDPREEILKAFRLFDDDKTGKISLKNLKRVAKELG-ETITDEELQEMIDEADRNGDGEISEEEFY 149


                  ...
gi 1216936615 141 VLM 143
Cdd:PTZ00183  150 RIM 152
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 89-143 9.67e-04

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 35.99  E-value: 9.67e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1216936615  89 LMDSEK-GVITFESLKRnsALLGL-QDLSDDDLRCMLKEGDFDGDGALNQMEFCVLM 143
Cdd:cd00051     8 LFDKDGdGTISADELKA--ALKSLgEGLSEEEIDEMIREVDKDGDGKIDFEEFLELM 62
 
Name Accession Description Interval E-value
EF-hand_8 pfam13833
EF-hand domain pair;
93-146 1.01e-18

EF-hand domain pair;


Pssm-ID: 404678 [Multi-domain]  Cd Length: 54  Bit Score: 75.04  E-value: 1.01e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1216936615  93 EKGVITFESLKRNSALLGLQDLSDDDLRCMLKEGDFDGDGALNQMEFCVLMFRL 146
Cdd:pfam13833   1 EKGVITREELKRALALLGLKDLSEDEVDILFREFDTDGDGYISFDEFCVLLERR 54
PTZ00183 PTZ00183
centrin; Provisional
 61-143 1.04e-11

centrin; Provisional


Pssm-ID: 185503 [Multi-domain]  Cd Length: 158  Bit Score: 59.70  E-value: 1.04e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1216936615  61 NFYDYLPVMAHKLGGDGLIGELCNGFNLLMDSEKGVITFESLKRNSALLGlQDLSDDDLRCMLKEGDFDGDGALNQMEFC 140
Cdd:PTZ00183   71 DFEEFLDIMTKKLGERDPREEILKAFRLFDDDKTGKISLKNLKRVAKELG-ETITDEELQEMIDEADRNGDGEISEEEFY 149


                  ...
gi 1216936615 141 VLM 143
Cdd:PTZ00183  150 RIM 152
PTZ00184 PTZ00184
calmodulin; Provisional
 54-145 4.16e-06

calmodulin; Provisional


Pssm-ID: 185504 [Multi-domain]  Cd Length: 149  Bit Score: 44.37  E-value: 4.16e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1216936615  54 QNQNPSSNFYDYLPVMAHKLGGDGLIGELCNGFNLLMDSEKGVITFESLKRNSALLGlQDLSDDDLRCMLKEGDFDGDGA 133
Cdd:PTZ00184   58 ADGNGTIDFPEFLTLMARKMKDTDSEEEIKEAFKVFDRDGNGFISAAELRHVMTNLG-EKLTDEEVDEMIREADVDGDGQ 136

                          90
                  ....*....|..
gi 1216936615 134 LNQMEFCVLMFR 145
Cdd:PTZ00184  137 INYEEFVKMMMS 148
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 89-143 9.67e-04

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 35.99  E-value: 9.67e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1216936615  89 LMDSEK-GVITFESLKRnsALLGL-QDLSDDDLRCMLKEGDFDGDGALNQMEFCVLM 143
Cdd:cd00051     8 LFDKDGdGTISADELKA--ALKSLgEGLSEEEIDEMIREVDKDGDGKIDFEEFLELM 62
PTZ00184 PTZ00184
calmodulin; Provisional
 79-145 5.98e-03

calmodulin; Provisional


Pssm-ID: 185504 [Multi-domain]  Cd Length: 149  Bit Score: 35.51  E-value: 5.98e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1216936615  79 IGELCNGFNLLMDSEKGVITFESLKRNSALLGlQDLSDDDLRCMLKEGDFDGDGALNQMEFCVLMFR 145
Cdd:PTZ00184   10 IAEFKEAFSLFDKDGDGTITTKELGTVMRSLG-QNPTEAELQDMINEVDADGNGTIDFPEFLTLMAR 75
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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