|
Name |
Accession |
Description |
Interval |
E-value |
| PRK00481 |
PRK00481 |
NAD-dependent deacetylase; Provisional |
19-252 |
1.85e-120 |
|
NAD-dependent deacetylase; Provisional
Pssm-ID: 234777 Cd Length: 242 Bit Score: 343.31 E-value: 1.85e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221437423 19 LKEMIDQSHNIVFFGGAGVSTASNIPDFRSSNGLFQKKSgmtisPEEILSHTFFINHTQEFFNFYRSKMVYV-DAKPNDA 97
Cdd:PRK00481 6 LAEILDKAKRIVVLTGAGISAESGIPDFRSANGLWEEHR-----PEDVASPEGFARDPELVWKFYNERRRQLlDAKPNAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221437423 98 HLALAKWEQEGKLKAVITQNIDGLHQLAGSINVLELHGSIHKNYCMRCHQPFDLDFVVASQGiPICSSCGGIVKPDVVLY 177
Cdd:PRK00481 81 HRALAELEKLGKLVTVITQNIDGLHERAGSKNVIELHGSLLRARCTKCGQTYDLDEYLKPEP-PRCPKCGGILRPDVVLF 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1221437423 178 EESLDSAILEKSISAISQADVFIVGGTSLTVYPAAGLV--SYYRGRKLVLVNKTATPFDTKAGLTVCGNIAEVFRQV 252
Cdd:PRK00481 160 GEMLPELAIDEAYEALEEADLFIVIGTSLVVYPAAGLPyeAREHGAKTVEINLEPTPLDSLFDLVIHGKAGEVVPEL 236
|
|
| SIR2 |
COG0846 |
NAD-dependent protein deacetylase, SIR2 family [Posttranslational modification, protein ... |
19-253 |
5.99e-114 |
|
NAD-dependent protein deacetylase, SIR2 family [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440607 Cd Length: 243 Bit Score: 326.73 E-value: 5.99e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221437423 19 LKEMIDQSHNIVFFGGAGVSTASNIPDFRSSNGLFQKKSgmtisPEEILSHTFFINHTQEFFNFYRSKM-VYVDAKPNDA 97
Cdd:COG0846 7 LAELLREAKRIVVLTGAGISAESGIPDFRGPDGLWEKYD-----PEEVASPEAFRRDPELVWAFYNERRrLLRDAEPNAA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221437423 98 HLALAKWEQEGKLKAVITQNIDGLHQLAGSINVLELHGSIHKNYCMRCHQPFDLDFV---VASQGIPICSSCGGIVKPDV 174
Cdd:COG0846 82 HRALAELEKAGKLVFVITQNVDGLHQRAGSKNVIELHGSLHRLRCTKCGKRYDLEDVledLEGELPPRCPKCGGLLRPDV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221437423 175 VLYEESLDSAILEKSISAISQADVFIVGGTSLTVYPAAGLVSYYR--GRKLVLVNKTATPFDTKAGLTVCGNIAEVFRQV 252
Cdd:COG0846 162 VWFGEMLPEEALERALEALAEADLFLVIGTSLVVYPAAGLPEYAKraGAPLVEINPEPTPLDSLADLVIRGDAGEVLPAL 241
|
.
gi 1221437423 253 A 253
Cdd:COG0846 242 V 242
|
|
| SIR2H |
cd01411 |
SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species ... |
19-249 |
2.64e-99 |
|
SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span.
Pssm-ID: 238702 Cd Length: 225 Bit Score: 288.88 E-value: 2.64e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221437423 19 LKEMIDQSHNIVFFGGAGVSTASNIPDFRSSNGLFQKKSGMtiSPEEILSHTFFINHTQEFFNFYRSKMVYVDAKPNDAH 98
Cdd:cd01411 1 LQHILKNAKRIVFFTGAGVSTASGIPDYRSKNGLYNEIYKY--SPEYLLSHDFLEREPEKFYQFVKENLYFPDAKPNIIH 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221437423 99 LALAKWEQEGkLKAVITQNIDGLHQLAGSINVLELHGSIHKNYCMRCHQPFDldfVVASQGIPICSSCGGIVKPDVVLYE 178
Cdd:cd01411 79 QKMAELEKMG-LKAVITQNIDGLHQKAGSKNVVEFHGSLYRIYCTVCGKTVD---WEEYLKSPYHAKCGGVIRPDIVLYE 154
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1221437423 179 ESLDSAILEKSISAISQADVFIVGGTSLTVYPAAGLVSYYR-GRKLVLVNKTATPFDTKAgLTVCGNIAEVF 249
Cdd:cd01411 155 EMLNESVIEEAIQAIEKADLLVIVGTSFVVYPFAGLIDYRQaGANLIAINKEPTQLDSPA-TLVIKDAVKVF 225
|
|
| prot_deacyl_CobB |
NF040867 |
NAD-dependent protein deacetylase; |
21-249 |
1.37e-79 |
|
NAD-dependent protein deacetylase;
Pssm-ID: 468804 Cd Length: 242 Bit Score: 239.40 E-value: 1.37e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221437423 21 EMIDQSHNIVFFGGAGVSTASNIPDFRSSNGLFQKksgmtISPEEILSHTFFINHTQEFFNFYRSKMVYV-DAKPNDAHL 99
Cdd:NF040867 5 ELLASSRHAIAFTGAGISTESGIPTFRGPDGLWRR-----YDPEELATIEAFERDPKLVWEFYRWRMEKLfDAKPNPAHY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221437423 100 ALAKWEQEGKLKAVITQNIDGLHQLAGSINVLELHGSIHKNYCMRCHQPFDLDFVVA----SQGIPICSSCGGIVKPDVV 175
Cdd:NF040867 80 ALAELERMGILKAVITQNVDGLHQRAGSRNVIELHGNMRRVRCTSCGRTYDLEEVLRkidkGELPPRCPECGGLLRPDVV 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1221437423 176 LYEESLDSAILEKSISAISQADVFIVGGTSLTVYPAAgLVSYY---RGRKLVLVNKTATPFDTKAGLTVCGNIAEVF 249
Cdd:NF040867 160 LFGEPLPDDALEEAFELAERSDVVLVVGSSLTVYPAA-YLPYIakeNGGKLIIINPEETPLDPIADIVLRGRAGEVL 235
|
|
| SIR2 |
pfam02146 |
Sir2 family; This region is characteriztic of Silent information regulator 2 (Sir2) proteins, ... |
34-210 |
9.24e-66 |
|
Sir2 family; This region is characteriztic of Silent information regulator 2 (Sir2) proteins, or sirtuins. These are protein deacetylases that depend on nicotine adenine dinucleotide (NAD). They are found in many subcellular locations, including the nucleus, cytoplasm and mitochondria. Eukaryotic forms play in important role in the regulation of transcriptional repression. Moreover, they are involved in microtubule organization and DNA damage repair processes.i
Pssm-ID: 426621 Cd Length: 179 Bit Score: 202.10 E-value: 9.24e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221437423 34 GAGVSTASNIPDFRSSNGLFQK-KSGMTISPEEILSHTFFINHTQEFFNFYRSKMVYvDAKPNDAHLALAKWEQEGKLKA 112
Cdd:pfam02146 1 GAGISTESGIPDFRSDDGLYAKlAPEELASPEAFFSNPELVWDPEPFYNIARELLPG-EAQPNPAHYFIAKLEDKGKLLR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221437423 113 VITQNIDGLHQLAGSINVLELHGSIHKNYCMRCHQPFDLD---FVVASQGIPICSSCGGIVKPDVVLYEESLDSAIlEKS 189
Cdd:pfam02146 80 LITQNIDGLHERAGSKKVVELHGSFAKARCVSCHQKYTGEtlyERIRPEKVPHCPQCGGLLKPDIVFFGENLPDKF-HRA 158
|
170 180
....*....|....*....|.
gi 1221437423 190 ISAISQADVFIVGGTSLTVYP 210
Cdd:pfam02146 159 YEDLEEADLLIVIGTSLKVYP 179
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK00481 |
PRK00481 |
NAD-dependent deacetylase; Provisional |
19-252 |
1.85e-120 |
|
NAD-dependent deacetylase; Provisional
Pssm-ID: 234777 Cd Length: 242 Bit Score: 343.31 E-value: 1.85e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221437423 19 LKEMIDQSHNIVFFGGAGVSTASNIPDFRSSNGLFQKKSgmtisPEEILSHTFFINHTQEFFNFYRSKMVYV-DAKPNDA 97
Cdd:PRK00481 6 LAEILDKAKRIVVLTGAGISAESGIPDFRSANGLWEEHR-----PEDVASPEGFARDPELVWKFYNERRRQLlDAKPNAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221437423 98 HLALAKWEQEGKLKAVITQNIDGLHQLAGSINVLELHGSIHKNYCMRCHQPFDLDFVVASQGiPICSSCGGIVKPDVVLY 177
Cdd:PRK00481 81 HRALAELEKLGKLVTVITQNIDGLHERAGSKNVIELHGSLLRARCTKCGQTYDLDEYLKPEP-PRCPKCGGILRPDVVLF 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1221437423 178 EESLDSAILEKSISAISQADVFIVGGTSLTVYPAAGLV--SYYRGRKLVLVNKTATPFDTKAGLTVCGNIAEVFRQV 252
Cdd:PRK00481 160 GEMLPELAIDEAYEALEEADLFIVIGTSLVVYPAAGLPyeAREHGAKTVEINLEPTPLDSLFDLVIHGKAGEVVPEL 236
|
|
| SIR2 |
COG0846 |
NAD-dependent protein deacetylase, SIR2 family [Posttranslational modification, protein ... |
19-253 |
5.99e-114 |
|
NAD-dependent protein deacetylase, SIR2 family [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440607 Cd Length: 243 Bit Score: 326.73 E-value: 5.99e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221437423 19 LKEMIDQSHNIVFFGGAGVSTASNIPDFRSSNGLFQKKSgmtisPEEILSHTFFINHTQEFFNFYRSKM-VYVDAKPNDA 97
Cdd:COG0846 7 LAELLREAKRIVVLTGAGISAESGIPDFRGPDGLWEKYD-----PEEVASPEAFRRDPELVWAFYNERRrLLRDAEPNAA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221437423 98 HLALAKWEQEGKLKAVITQNIDGLHQLAGSINVLELHGSIHKNYCMRCHQPFDLDFV---VASQGIPICSSCGGIVKPDV 174
Cdd:COG0846 82 HRALAELEKAGKLVFVITQNVDGLHQRAGSKNVIELHGSLHRLRCTKCGKRYDLEDVledLEGELPPRCPKCGGLLRPDV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221437423 175 VLYEESLDSAILEKSISAISQADVFIVGGTSLTVYPAAGLVSYYR--GRKLVLVNKTATPFDTKAGLTVCGNIAEVFRQV 252
Cdd:COG0846 162 VWFGEMLPEEALERALEALAEADLFLVIGTSLVVYPAAGLPEYAKraGAPLVEINPEPTPLDSLADLVIRGDAGEVLPAL 241
|
.
gi 1221437423 253 A 253
Cdd:COG0846 242 V 242
|
|
| SIR2H |
cd01411 |
SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species ... |
19-249 |
2.64e-99 |
|
SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span.
Pssm-ID: 238702 Cd Length: 225 Bit Score: 288.88 E-value: 2.64e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221437423 19 LKEMIDQSHNIVFFGGAGVSTASNIPDFRSSNGLFQKKSGMtiSPEEILSHTFFINHTQEFFNFYRSKMVYVDAKPNDAH 98
Cdd:cd01411 1 LQHILKNAKRIVFFTGAGVSTASGIPDYRSKNGLYNEIYKY--SPEYLLSHDFLEREPEKFYQFVKENLYFPDAKPNIIH 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221437423 99 LALAKWEQEGkLKAVITQNIDGLHQLAGSINVLELHGSIHKNYCMRCHQPFDldfVVASQGIPICSSCGGIVKPDVVLYE 178
Cdd:cd01411 79 QKMAELEKMG-LKAVITQNIDGLHQKAGSKNVVEFHGSLYRIYCTVCGKTVD---WEEYLKSPYHAKCGGVIRPDIVLYE 154
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1221437423 179 ESLDSAILEKSISAISQADVFIVGGTSLTVYPAAGLVSYYR-GRKLVLVNKTATPFDTKAgLTVCGNIAEVF 249
Cdd:cd01411 155 EMLNESVIEEAIQAIEKADLLVIVGTSFVVYPFAGLIDYRQaGANLIAINKEPTQLDSPA-TLVIKDAVKVF 225
|
|
| SIR2-fam |
cd01407 |
SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze ... |
28-237 |
6.53e-94 |
|
SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, producing nicotinamide and the novel metabolite O-acetyl-ADP-ribose. Sir2 proteins, also known as sirtuins, are found in all eukaryotes and many archaea and prokaryotes and have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. The most-studied function, gene silencing, involves the inactivation of chromosome domains containing key regulatory genes by packaging them into a specialized chromatin structure that is inaccessible to DNA-binding proteins. The oligomerization state of Sir2 appears to be organism-dependent, sometimes occurring as a monomer and sometimes as a multimer.
Pssm-ID: 238698 Cd Length: 218 Bit Score: 274.83 E-value: 6.53e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221437423 28 NIVFFGGAGVSTASNIPDFRSSNGLFQKksgmtISPEEI-LSHTFFINHTQEFFNFYRSKMVYVDAKPNDAHLALAKWEQ 106
Cdd:cd01407 2 RIVVLTGAGISTESGIPDFRSPGGLWAR-----LDPEELaFSPEAFRRDPELFWGFYRERRYPLNAQPNPAHRALAELER 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221437423 107 EGKLKAVITQNIDGLHQLAGSINVLELHGSIHKNYCMRCHQPFDLDFVVA---SQGIPICSSCGGIVKPDVVLYEESLDS 183
Cdd:cd01407 77 KGKLKRVITQNVDGLHQRAGSPKVIELHGSLFRVRCTKCGKEYPRDELQAdidREEVPRCPKCGGLLRPDVVFFGESLPE 156
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 1221437423 184 AILEkSISAISQADVFIVGGTSLTVYPAAGLVSYY--RGRKLVLVNKTATPFDTKA 237
Cdd:cd01407 157 ELDE-AAEALAKADLLLVIGTSLQVYPAAGLPLYApeRGAPVVIINLEPTPADRKA 211
|
|
| SIR2_Af2 |
cd01413 |
SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, ... |
23-241 |
1.66e-85 |
|
SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, Sulfolobus solfataricus ssSir2, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. The Sir2 homolog from the archaea Sulfolobus solftaricus deacetylates the non-specific DNA protein Alba to mediate transcription repression.
Pssm-ID: 238704 Cd Length: 222 Bit Score: 253.83 E-value: 1.66e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221437423 23 IDQSHNIVFFGGAGVSTASNIPDFRSSNGLFQKKSgmtisPEEILSHTFFINHTQEFFNFYRSKMVYV-DAKPNDAHLAL 101
Cdd:cd01413 1 LTKSRKTVVLTGAGISTESGIPDFRSPDGLWKKYD-----PEEVASIDYFYRNPEEFWRFYKEIILGLlEAQPNKAHYFL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221437423 102 AKWEQEGKLKAVITQNIDGLHQLAGSINVLELHGSIHKNYCMRCHQPFDLDFV--VASQGIPICSSCGGIVKPDVVLYEE 179
Cdd:cd01413 76 AELEKQGIIKAIITQNIDGLHQRAGSKNVIELHGTLQTAYCVNCGSKYDLEEVkyAKKHEVPRCPKCGGIIRPDVVLFGE 155
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1221437423 180 SLDSAILEKSISAISQADVFIVGGTSLTVYPAAGL--VSYYRGRKLVLVNKTATPFDTKAGLTV 241
Cdd:cd01413 156 PLPQALLREAIEAAKEADLFIVLGSSLVVYPANLLplIAKENGAKLVIVNADETPFDYIADLVI 219
|
|
| SIR2 |
cd00296 |
SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which ... |
28-236 |
6.92e-80 |
|
SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, producing nicotinamide and the novel metabolite O-acetyl-ADP-ribose. Sir2 proteins, also known as sirtuins, are found in all eukaryotes and many archaea and prokaryotes and have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. The most-studied function, gene silencing, involves the inactivation of chromosome domains containing key regulatory genes by packaging them into a specialized chromatin structure that is inaccessible to DNA-binding proteins. The oligomerization state of Sir2 appears to be organism-dependent, sometimes occurring as a monomer and sometimes as a multimer. Also included in this superfamily is a group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines.
Pssm-ID: 238184 [Multi-domain] Cd Length: 222 Bit Score: 239.55 E-value: 6.92e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221437423 28 NIVFFGGAGVSTASNIPDFRSSN-GLFQKksgmtISPEEI-LSHTFFINHTQEFFNFYRSKM-VYVDAKPNDAHLALAKW 104
Cdd:cd00296 2 RVVVFTGAGISTESGIPDFRGLGtGLWTR-----LDPEELaFSPEAFRRDPELFWLFYKERRyTPLDAKPNPAHRALAEL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221437423 105 EQEGKLKAVITQNIDGLHQLAGS--INVLELHGSIHKNYCMRCHQPFDLDFVVASQGIPICSSCGGIVKPDVVLYEESLD 182
Cdd:cd00296 77 ERKGKLKRIITQNVDGLHERAGSrrNRVIELHGSLDRVRCTSCGKEYPRDEVLEREKPPRCPKCGGLLRPDVVDFGEALP 156
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 1221437423 183 SAILEKSISAISQADVFIVGGTSLTVYPAAGLVSYY--RGRKLVLVNKTATPFDTK 236
Cdd:cd00296 157 KEWFDRALEALLEADLVLVIGTSLTVYPAARLLLRApeRGAPVVIINREPTPADAL 212
|
|
| prot_deacyl_CobB |
NF040867 |
NAD-dependent protein deacetylase; |
21-249 |
1.37e-79 |
|
NAD-dependent protein deacetylase;
Pssm-ID: 468804 Cd Length: 242 Bit Score: 239.40 E-value: 1.37e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221437423 21 EMIDQSHNIVFFGGAGVSTASNIPDFRSSNGLFQKksgmtISPEEILSHTFFINHTQEFFNFYRSKMVYV-DAKPNDAHL 99
Cdd:NF040867 5 ELLASSRHAIAFTGAGISTESGIPTFRGPDGLWRR-----YDPEELATIEAFERDPKLVWEFYRWRMEKLfDAKPNPAHY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221437423 100 ALAKWEQEGKLKAVITQNIDGLHQLAGSINVLELHGSIHKNYCMRCHQPFDLDFVVA----SQGIPICSSCGGIVKPDVV 175
Cdd:NF040867 80 ALAELERMGILKAVITQNVDGLHQRAGSRNVIELHGNMRRVRCTSCGRTYDLEEVLRkidkGELPPRCPECGGLLRPDVV 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1221437423 176 LYEESLDSAILEKSISAISQADVFIVGGTSLTVYPAAgLVSYY---RGRKLVLVNKTATPFDTKAGLTVCGNIAEVF 249
Cdd:NF040867 160 LFGEPLPDDALEEAFELAERSDVVLVVGSSLTVYPAA-YLPYIakeNGGKLIIINPEETPLDPIADIVLRGRAGEVL 235
|
|
| SIR2 |
pfam02146 |
Sir2 family; This region is characteriztic of Silent information regulator 2 (Sir2) proteins, ... |
34-210 |
9.24e-66 |
|
Sir2 family; This region is characteriztic of Silent information regulator 2 (Sir2) proteins, or sirtuins. These are protein deacetylases that depend on nicotine adenine dinucleotide (NAD). They are found in many subcellular locations, including the nucleus, cytoplasm and mitochondria. Eukaryotic forms play in important role in the regulation of transcriptional repression. Moreover, they are involved in microtubule organization and DNA damage repair processes.i
Pssm-ID: 426621 Cd Length: 179 Bit Score: 202.10 E-value: 9.24e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221437423 34 GAGVSTASNIPDFRSSNGLFQK-KSGMTISPEEILSHTFFINHTQEFFNFYRSKMVYvDAKPNDAHLALAKWEQEGKLKA 112
Cdd:pfam02146 1 GAGISTESGIPDFRSDDGLYAKlAPEELASPEAFFSNPELVWDPEPFYNIARELLPG-EAQPNPAHYFIAKLEDKGKLLR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221437423 113 VITQNIDGLHQLAGSINVLELHGSIHKNYCMRCHQPFDLD---FVVASQGIPICSSCGGIVKPDVVLYEESLDSAIlEKS 189
Cdd:pfam02146 80 LITQNIDGLHERAGSKKVVELHGSFAKARCVSCHQKYTGEtlyERIRPEKVPHCPQCGGLLKPDIVFFGENLPDKF-HRA 158
|
170 180
....*....|....*....|.
gi 1221437423 190 ISAISQADVFIVGGTSLTVYP 210
Cdd:pfam02146 159 YEDLEEADLLIVIGTSLKVYP 179
|
|
| SIRT5_Af1_CobB |
cd01412 |
SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human ... |
28-248 |
1.41e-63 |
|
SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. CobB is a bacterial sirtuin that deacetylates acetyl-CoA synthetase at an active site lysine to stimulate its enzymatic activity.
Pssm-ID: 238703 Cd Length: 224 Bit Score: 198.20 E-value: 1.41e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221437423 28 NIVFFGGAGVSTASNIPDFRSSNGLFQKksgmtISPEEILS-HTFFIN--HTQEFFNfYRSKMVYvDAKPNDAHLALAKW 104
Cdd:cd01412 2 RVVVLTGAGISAESGIPTFRDADGLWAR-----FDPEELATpEAFARDpeLVWEFYN-WRRRKAL-RAQPNPAHLALAEL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221437423 105 EQEGKLKAVITQNIDGLHQLAGSINVLELHGSIHKNYCMRCHQPFDLDFVVASQGIPICSSCGGIVKPDVVLYEESLDSA 184
Cdd:cd01412 75 ERRLPNVLLITQNVDGLHERAGSRNVIELHGSLFRVRCSSCGYVGENNEEIPEEELPRCPKCGGLLRPGVVWFGESLPLA 154
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1221437423 185 ILEkSISAISQADVFIVGGTSLTVYPAAGLVSYYRGRK--LVLVNKTATPFDTKAGLTVCGNIAEV 248
Cdd:cd01412 155 LLE-AVEALAKADLFLVIGTSGVVYPAAGLPEEAKERGarVIEINPEPTPLSPIADFAFRGKAGEV 219
|
|
| PRK14138 |
PRK14138 |
NAD-dependent deacetylase; Provisional |
21-252 |
9.13e-63 |
|
NAD-dependent deacetylase; Provisional
Pssm-ID: 172627 [Multi-domain] Cd Length: 244 Bit Score: 196.97 E-value: 9.13e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221437423 21 EMIDQSHNIVFFGGAGVSTASNIPDFRSSNGLFQKksgmtiSPEEILSHTFFINHTQEFFNFYRSKMV-YVDAKPNDAHL 99
Cdd:PRK14138 6 ELLNESRLTVTLTGAGISTPSGIPDFRGPQGIYKK------YPQNVFDIDFFYSHPEEFYRFAKEGIFpMLEAKPNLAHV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221437423 100 ALAKWEQEGKLKAVITQNIDGLHQLAGSINVLELHGSIHKNYCMRCHQPFDLDFV---VASQGIPICSSCGGIVKPDVVL 176
Cdd:PRK14138 80 LLAKLEEKGLIEAVITQNIDRLHQKAGSKKVIELHGNVEEYYCVRCGKRYTVEDViekLEKSDVPRCDDCSGLIRPNIVF 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1221437423 177 YEESLDSAILEKSISAISQADVFIVGGTSLTVYPAAGL--VSYYRGRKLVLVNKTATPFDTKAGLTVCGNIAEVFRQV 252
Cdd:PRK14138 160 FGEALPQDALREAIRLSSKASLMIVMGSSLVVYPAAELplITVRSGGKLVIVNLGETPLDDIATLKYNMDVVEFANRV 237
|
|
| SIRT7 |
cd01410 |
SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, ... |
29-239 |
1.92e-56 |
|
SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span.
Pssm-ID: 238701 Cd Length: 206 Bit Score: 179.42 E-value: 1.92e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221437423 29 IVFFGGAGVSTASNIPDFRSSNGLFQKKSGMTISPEEilSHTFfinhtqeffnfyRSkmvyvdAKPNDAHLALAKWEQEG 108
Cdd:cd01410 3 LVVFTGAGISTSAGIPDFRGPNGVWTLLPEDKGRRRF--SWRF------------RR------AEPTLTHMALVELERAG 62
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221437423 109 KLKAVITQNIDGLHQLAG--SINVLELHGSIHKNYCMRCHQPFDLDFVVASQGI----PICSSCGGIVKPDVVLYEESLD 182
Cdd:cd01410 63 LLKFVISQNVDGLHLRSGlpREKLSELHGNMFIEVCKSCGPEYVRDDVVETRGDketgRRCHACGGILKDTIVDFGERLP 142
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 1221437423 183 SAILEKSISAISQADVFIVGGTSLTVYPAAGL--VSYYRGRKLVLVNKTATPFDTKAGL 239
Cdd:cd01410 143 PENWMGAAAAACRADLFLCLGTSLQVTPAANLplKAARAGGRLVIVNLQPTPKDKLADL 201
|
|
| SIRT4 |
cd01409 |
SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and ... |
19-249 |
5.73e-46 |
|
SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span.
Pssm-ID: 238700 Cd Length: 260 Bit Score: 154.38 E-value: 5.73e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221437423 19 LKEMIDQSHNIVFFGGAGVSTASNIPDFRSSNGLFQKksgmTISPeeilshtffINHtQEFFNFYRSKMVY--------- 89
Cdd:cd01409 1 LQDFVARSRRLLVLTGAGISTESGIPDYRSEGGLYSR----TFRP---------MTH-QEFMRSPAARQRYwarsfvgwp 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221437423 90 --VDAKPNDAHLALAKWEQEGKLKAVITQNIDGLHQLAGSINVLELHGSIHKNYCMRC---------------HQP---- 148
Cdd:cd01409 67 rfSAAQPNAAHRALAALEAAGRLHGLITQNVDGLHTKAGSRNVVELHGSLHRVVCLSCgfrtpraelqdrleaLNPgfae 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221437423 149 -----------FDLDFVVASQGIPICSSCGGIVKPDVVLYEESLDSAILEKSISAISQADVFIVGGTSLTVYPAAGLV-- 215
Cdd:cd01409 147 qaagqapdgdvDLEDEQVAGFRVPECERCGGVLKPDVVFFGENVPRDRVVTAAARLAEADALLVLGSSLMVYSGYRFVla 226
|
250 260 270
....*....|....*....|....*....|....
gi 1221437423 216 SYYRGRKLVLVNKTATPFDTKAGLTVCGNIAEVF 249
Cdd:cd01409 227 AAEAGLPIAIVNIGPTRADHLATLKVDARCGEVL 260
|
|
| SIRT1 |
cd01408 |
SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and ... |
28-232 |
2.62e-45 |
|
SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, and life span. The most-studied function, gene silencing, involves the inactivation of chromosome domains containing key regulatory genes by packaging them into a specialized chromatin structure that is inaccessible to DNA-binding proteins. The nuclear SIRT1 has been shown to target the p53 tumor suppressor protein for deacetylation to suppress DNA damage, and the cytoplasmic SIRT2 homolog has been shown to target alpha-tubulin for deacetylation for the maintenance of cell integrity.
Pssm-ID: 238699 Cd Length: 235 Bit Score: 151.63 E-value: 2.62e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221437423 28 NIVFFGGAGVSTASNIPDFRSSN-GLFQKKSGMTIS-PEEILSHTFFINHTQEFFNFyrSKMVYV-DAKPNDAHLALAKW 104
Cdd:cd01408 2 KIVVLVGAGISTSAGIPDFRSPGtGLYANLARYNLPyPEAMFDISYFRKNPRPFYAL--AKELYPgQFKPSVAHYFIKLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221437423 105 EQEGKLKAVITQNIDGLHQLAG--SINVLELHGSIHKNYCMRCHQPFDLDFV---VASQGIPICSSCGGIVKPDVVLYEE 179
Cdd:cd01408 80 EDKGLLLRNYTQNIDTLERVAGvpDDRIIEAHGSFATAHCIKCKHKYPGDWMredIFNQEVPKCPRCGGLVKPDIVFFGE 159
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 1221437423 180 SLDSAILEKSISAISQADVFIVGGTSLTVYPAAGLVSYYRGR-KLVLVNKTATP 232
Cdd:cd01408 160 SLPSRFFSHMEEDKEEADLLIVIGTSLKVAPFASLPSRVPSEvPRVLINREPVG 213
|
|
| PRK05333 |
PRK05333 |
NAD-dependent protein deacetylase; |
19-219 |
1.83e-42 |
|
NAD-dependent protein deacetylase;
Pssm-ID: 235415 Cd Length: 285 Bit Score: 145.98 E-value: 1.83e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221437423 19 LKEMIDQSHNIVFFGGAGVSTASNIPDFRSSNGLFQKKSGMTIspeeilsHTFFINHTQEFFNFYRSKM---VYVDAKPN 95
Cdd:PRK05333 12 LQDFVERHPRLFVLTGAGISTDSGIPDYRDRNGQWKRSPPITY-------QAFMGSDAARRRYWARSMVgwpVFGRAQPN 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221437423 96 DAHLALAKWEQEGKLKAVITQNIDGLHQLAGSINVLELHGSIHKNYCMRC--HQP---------------FDLDFVVASQ 158
Cdd:PRK05333 85 AAHHALARLGAAGRIERLVTQNVDGLHQRAGSRDVIELHGRLDGVRCMGCgaRHPraeiqhvleaanpewLALEAAPAPD 164
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1221437423 159 G-------------IPICSSCGGIVKPDVVLYEESLDSAILEKSISAISQADVFIVGGTSLTVYpaaglvSYYR 219
Cdd:PRK05333 165 GdadlewaafdhfrVPACPACGGILKPDVVFFGENVPRERVAAARAALDAADAVLVVGSSLMVY------SGYR 232
|
|
| PTZ00408 |
PTZ00408 |
NAD-dependent deacetylase; Provisional |
29-215 |
3.04e-38 |
|
NAD-dependent deacetylase; Provisional
Pssm-ID: 240405 Cd Length: 242 Bit Score: 133.79 E-value: 3.04e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221437423 29 IVFFGGAGVSTASNIPDFRSSNGLFQKksgmtISPEEILS-HTFFINHT--QEFFNFYRSKMVYVDAKPNDAHLALAKWE 105
Cdd:PTZ00408 7 ITILTGAGISAESGISTFRDGNGLWEN-----HRVEDVATpDAFLRNPAlvQRFYNERRRALLSSSVKPNKAHFALAKLE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221437423 106 QE--GKLKAVITQNIDGLHQLAGSINVLELHGSIHKNYCMRCHQPFDLDFVVAsQGIPICSSCG--GIVKPDVVLYEESl 181
Cdd:PTZ00408 82 REyrGGKVVVVTQNVDNLHERAGSTHVLHMHGELLKVRCTATGHVFDWTEDVV-HGSSRCKCCGcvGTLRPHIVWFGEM- 159
|
170 180 190
....*....|....*....|....*....|....
gi 1221437423 182 dSAILEKSISAISQADVFIVGGTSLTVYPAAGLV 215
Cdd:PTZ00408 160 -PLYMDEIESVMSKTDLFVAVGTSGNVYPAAGFV 192
|
|
| PTZ00409 |
PTZ00409 |
Sir2 (Silent Information Regulator) protein; Provisional |
19-231 |
2.99e-36 |
|
Sir2 (Silent Information Regulator) protein; Provisional
Pssm-ID: 173599 [Multi-domain] Cd Length: 271 Bit Score: 129.27 E-value: 2.99e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221437423 19 LKEMIDQSHNIVFFGGAGVSTASNIPDFRSSNGLFQKKSGMTI---------SPEEILSHTFFINHTQEFfnfyrskmvy 89
Cdd:PTZ00409 21 LADMIRKCKYVVALTGSGTSAESNIPSFRGPSSSIWSKYDPKIygtiwgfwkYPEKIWEVIRDISSDYEI---------- 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221437423 90 vdaKPNDAHLALAKWEQEGKLKAVITQNIDGLHQLAGSINVLELHGSIHKNYCMRCHQPFDLDFVV-------ASQGIPI 162
Cdd:PTZ00409 91 ---ELNPGHVALSTLESLGYLKFVVTQNVDGLHEESGNTKVIPLHGSVFEARCCTCRKTIQLNKIMlqktshfMHQLPPE 167
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1221437423 163 CsSCGGIVKPDVVLYEESLDSAILEKSISAISQADVFIVGGTSLTVYPAAGLVSY--YRGRKLVLVNKTAT 231
Cdd:PTZ00409 168 C-PCGGIFKPNVILFGEVIPKSLLKQAEKEIDKCDLLLVVGTSSSVSTATNLCYRahRKKKKIVEVNISKT 237
|
|
| PTZ00410 |
PTZ00410 |
NAD-dependent SIR2; Provisional |
29-214 |
8.08e-29 |
|
NAD-dependent SIR2; Provisional
Pssm-ID: 185600 Cd Length: 349 Bit Score: 111.50 E-value: 8.08e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221437423 29 IVFFGGAGVSTASNIPDFRSSN-GLFQKKSGMTI-SPEEILSHTFFINHTQEFFNFYRSKMVYVDA-KPNDAHLALAKWE 105
Cdd:PTZ00410 32 ILVMVGAGISVAAGIPDFRSPHtGIYAKLGKYNLnSPTDAFSLTLLREKPEVFYSIAREMDLWPGHfQPTAVHHFIRLLA 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221437423 106 QEGKLKAVITQNIDGLHQLAG-SINVL-ELHGSIHKNYCMRCHQPFDLDFVVA---SQGIPICSSCGGIVKPDVVLYEES 180
Cdd:PTZ00410 112 DEGRLLRCCTQNIDGLERAAGvPPSLLvEAHGSFSAASCIECHTPYDIEQAYLearSGKVPHCSTCGGIVKPDVVFFGEN 191
|
170 180 190
....*....|....*....|....*....|....
gi 1221437423 181 LDSAILEKSiSAISQADVFIVGGTSLTVYPAAGL 214
Cdd:PTZ00410 192 LPDAFFNVH-HDIPEAELLLIIGTSLQVHPFALL 224
|
|
| |
