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Conserved domains on  [gi|1226043814|gb|ASO76681|]
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Dachs, partial [Strongylocentrotus pallidus]

Protein Classification

cadherin repeat domain-containing protein( domain architecture ID 10182011)

cadherin repeat domain-containing protein similar to cadherins, which are calcium-dependent cell adhesion proteins that preferentially interact with themselves in connecting cells

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  28268172
SCOP:  4007535

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 23-121 5.59e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 112.41  E-value: 5.59e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1226043814  23 IYSASVSENVSLGHHVITVVAEDMDlSPENSKINYFIESGNDQGKFKIDANDG*ITVLER*DREATDTYTLIIGAVDNGE 102
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPD-SGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG 79

                          90
                  ....*....|....*....
gi 1226043814 103 PVNNATAEVVIEVEDINDH 121
Cdd:cd11304    80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 129-226 1.35e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 103.55  E-value: 1.35e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1226043814 129 QYEGRIAENATASTYILTVHATDRDIGYNGEVEYSIISGTYSDLFAIDVVSGAVTVRGELDREEVERVEFTVQASDRGmE 208
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG-G 79

                          90
                  ....*....|....*...
gi 1226043814 209 NQLASVVLVTITITDFNE 226
Cdd:cd11304    80 PPLSSTATVTITVLDVND 97
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 23-121 5.59e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 112.41  E-value: 5.59e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1226043814  23 IYSASVSENVSLGHHVITVVAEDMDlSPENSKINYFIESGNDQGKFKIDANDG*ITVLER*DREATDTYTLIIGAVDNGE 102
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPD-SGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG 79

                          90
                  ....*....|....*....
gi 1226043814 103 PVNNATAEVVIEVEDINDH 121
Cdd:cd11304    80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 129-226 1.35e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 103.55  E-value: 1.35e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1226043814 129 QYEGRIAENATASTYILTVHATDRDIGYNGEVEYSIISGTYSDLFAIDVVSGAVTVRGELDREEVERVEFTVQASDRGmE 208
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG-G 79

                          90
                  ....*....|....*...
gi 1226043814 209 NQLASVVLVTITITDFNE 226
Cdd:cd11304    80 PPLSSTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 42-123 1.34e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 87.79  E-value: 1.34e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1226043814   42 VAEDMDlSPENSKINYFIESGNDQGKFKIDANDG*ITVLER*DREATDTYTLIIGAVDNGEPVNNATAEVVIEVEDINDH 121
Cdd:smart00112   1 SATDAD-SGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                   ..
gi 1226043814  122 SP 123
Cdd:smart00112  80 AP 81
Cadherin pfam00028
Cadherin domain;
24-116 4.99e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 83.89  E-value: 4.99e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1226043814  24 YSASVSENVSLGHHVITVVAEDMDLSPeNSKINYFIESGNDQGKFKIDANDG*ITVLER*DREATDTYTLIIGAVDNGEP 103
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGP-NGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79

                          90
                  ....*....|...
gi 1226043814 104 VNNATAEVVIEVE 116
Cdd:pfam00028  80 PLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 148-229 1.38e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 82.40  E-value: 1.38e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1226043814  148 HATDRDIGYNGEVEYSIISGTYSDLFAIDVVSGAVTVRGELDREEVERVEFTVQASDRGmENQLASVVLVTITITDFNEF 227
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGG-GPPLSSTATVTITVLDVNDN 79


                   ..
gi 1226043814  228 PP 229
Cdd:smart00112  80 AP 81
Cadherin pfam00028
Cadherin domain;
130-222 1.99e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 82.35  E-value: 1.99e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1226043814 130 YEGRIAENATASTYILTVHATDRDIGYNGEVEYSIISGTYSDLFAIDVVSGAVTVRGELDREEVERVEFTVQASDRGmEN 209
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG-GP 79

                          90
                  ....*....|...
gi 1226043814 210 QLASVVLVTITIT 222
Cdd:pfam00028  80 PLSSTATVTITVL 92
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 23-121 5.59e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 112.41  E-value: 5.59e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1226043814  23 IYSASVSENVSLGHHVITVVAEDMDlSPENSKINYFIESGNDQGKFKIDANDG*ITVLER*DREATDTYTLIIGAVDNGE 102
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPD-SGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG 79

                          90
                  ....*....|....*....
gi 1226043814 103 PVNNATAEVVIEVEDINDH 121
Cdd:cd11304    80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 129-226 1.35e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 103.55  E-value: 1.35e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1226043814 129 QYEGRIAENATASTYILTVHATDRDIGYNGEVEYSIISGTYSDLFAIDVVSGAVTVRGELDREEVERVEFTVQASDRGmE 208
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG-G 79

                          90
                  ....*....|....*...
gi 1226043814 209 NQLASVVLVTITITDFNE 226
Cdd:cd11304    80 PPLSSTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 42-123 1.34e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 87.79  E-value: 1.34e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1226043814   42 VAEDMDlSPENSKINYFIESGNDQGKFKIDANDG*ITVLER*DREATDTYTLIIGAVDNGEPVNNATAEVVIEVEDINDH 121
Cdd:smart00112   1 SATDAD-SGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                   ..
gi 1226043814  122 SP 123
Cdd:smart00112  80 AP 81
Cadherin pfam00028
Cadherin domain;
24-116 4.99e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 83.89  E-value: 4.99e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1226043814  24 YSASVSENVSLGHHVITVVAEDMDLSPeNSKINYFIESGNDQGKFKIDANDG*ITVLER*DREATDTYTLIIGAVDNGEP 103
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGP-NGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79

                          90
                  ....*....|...
gi 1226043814 104 VNNATAEVVIEVE 116
Cdd:pfam00028  80 PLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 148-229 1.38e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 82.40  E-value: 1.38e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1226043814  148 HATDRDIGYNGEVEYSIISGTYSDLFAIDVVSGAVTVRGELDREEVERVEFTVQASDRGmENQLASVVLVTITITDFNEF 227
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGG-GPPLSSTATVTITVLDVNDN 79


                   ..
gi 1226043814  228 PP 229
Cdd:smart00112  80 AP 81
Cadherin pfam00028
Cadherin domain;
130-222 1.99e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 82.35  E-value: 1.99e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1226043814 130 YEGRIAENATASTYILTVHATDRDIGYNGEVEYSIISGTYSDLFAIDVVSGAVTVRGELDREEVERVEFTVQASDRGmEN 209
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG-GP 79

                          90
                  ....*....|...
gi 1226043814 210 QLASVVLVTITIT 222
Cdd:pfam00028  80 PLSSTATVTITVL 92
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 27-121 2.81e-03

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 36.17  E-value: 2.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1226043814  27 SVSENVSLGHHVITVVAEDMDLSPENSKInyfIESGNDQ--GKFKIDANDG*ITVLER*DREATDTYTLIIGAVDNGEPV 104
Cdd:cd00031     5 SAVEGRSRGSFRVSIPTDLIASSGEIIKI---SAAGKEAlpSWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGANV 81

                          90
                  ....*....|....*..
gi 1226043814 105 NNATAEVVIEVEDINDH 121
Cdd:cd00031    82 PQTSSVFSIEVYDENDN 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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