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Conserved domains on  [gi|124056474|sp|P01042|]
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RecName: Full=Kininogen-1; AltName: Full=Alpha-2-thiol proteinase inhibitor; AltName: Full=Fitzgerald factor; AltName: Full=High molecular weight kininogen; Short=HMWK; AltName: Full=Williams-Fitzgerald-Flaujeac factor; Contains: RecName: Full=Kininogen-1 heavy chain; Contains: RecName: Full=T-kinin; AltName: Full=Ile-Ser-Bradykinin; Contains: RecName: Full=Bradykinin; AltName: Full=Kallidin I; Contains: RecName: Full=Lysyl-bradykinin; AltName: Full=Kallidin II; Contains: RecName: Full=Kininogen-1 light chain; Contains: RecName: Full=Low molecular weight growth-promoting factor; Flags: Precursor

Protein Classification

CY domain-containing protein( domain architecture ID 10440427)

CY domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 266-360 2.80e-31

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


:

Pssm-ID: 425431  Cd Length: 92  Bit Score: 117.05  E-value: 2.80e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124056474  266 GCPRDIPTNSPELEETLTHTITKLNAENNaTFYFKIDNVKKARVQVVAGKKYFIDFVARETTCSKesNEELTESCETKKL 345
Cdd:pfam00031   1 GGLSPIPDNSPELQEALDFALAEYNAKTD-NYYFELVEVKRAKSQVVAGTNYFIKVEVGETDCSK--SKKLLEDCPLLDE 77

                          90
                  ....*....|....*
gi 124056474  346 GQSLDCNAEVYVVPW 360
Cdd:pfam00031  78 KWLGLCSAQVYKVPW 92
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 144-237 4.23e-29

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


:

Pssm-ID: 425431  Cd Length: 92  Bit Score: 110.89  E-value: 4.23e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124056474  144 GCVHPISTQSPDLEPILRHGIQYFNNNTqHSSLFMLNEVKRAQRQVVAGLNFRITYSIVQTNCSKenFLFLTPDCKSLWN 223
Cdd:pfam00031   1 GGLSPIPDNSPELQEALDFALAEYNAKT-DNYYFELVEVKRAKSQVVAGTNYFIKVEVGETDCSK--SKKLLEDCPLLDE 77

                          90
                  ....*....|....
gi 124056474  224 GDTGECTDNAYIDI 237
Cdd:pfam00031  78 KWLGLCSAQVYKVP 91
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 24-114 1.12e-22

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


:

Pssm-ID: 425431  Cd Length: 92  Bit Score: 92.40  E-value: 1.12e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124056474   24 EEIDCNDKDLFKAVDAALKKYNSQNqSNNQFVLYRITEATKTVGSDTFYSFKYEIKEGDCPVqSGKTWQDCEYKDaaKAA 103
Cdd:pfam00031   4 SPIPDNSPELQEALDFALAEYNAKT-DNYYFELVEVKRAKSQVVAGTNYFIKVEVGETDCSK-SKKLLEDCPLLD--EKW 79

                          90
                  ....*....|.
gi 124056474  104 TGECTATVGKR 114
Cdd:pfam00031  80 LGLCSAQVYKV 90
ureE super family cl29393
urease accessory protein UreE; Provisional
 423-469 3.40e-04

urease accessory protein UreE; Provisional


The actual alignment was detected with superfamily member PRK13263:

Pssm-ID: 237323  Cd Length: 206  Bit Score: 42.47  E-value: 3.40e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 124056474 423 QGHTRRHDwGHEkqrkHNLGHGHkHERDQGHGHQRGHGLGHGHEQQH 469
Cdd:PRK13263 165 QQVFHEHH-GHS----HSHSDHD-HDHDHDHDHVHGPGCGHGHHHHH 205
 
Name Accession Description Interval E-value
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 266-360 2.80e-31

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 117.05  E-value: 2.80e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124056474  266 GCPRDIPTNSPELEETLTHTITKLNAENNaTFYFKIDNVKKARVQVVAGKKYFIDFVARETTCSKesNEELTESCETKKL 345
Cdd:pfam00031   1 GGLSPIPDNSPELQEALDFALAEYNAKTD-NYYFELVEVKRAKSQVVAGTNYFIKVEVGETDCSK--SKKLLEDCPLLDE 77

                          90
                  ....*....|....*
gi 124056474  346 GQSLDCNAEVYVVPW 360
Cdd:pfam00031  78 KWLGLCSAQVYKVPW 92
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 264-371 2.36e-30

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 114.83  E-value: 2.36e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124056474   264 CVGCPRDIPTNSPELEETLTHTITKLNAENNATFYFKIDNVKKARVQVVAGKKYFIDFVARETTCSKESneELTESCETK 343
Cdd:smart00043   2 CLGGPSDVPPNDPEVQEAADFAVAEYNKKSNDKYELRVIKVVSAKSQVVAGTNYYLKVEVGETNCKKLS--VDLENCPFL 79

                           90       100
                   ....*....|....*....|....*....
gi 124056474   344 KLGQsLDCNAEVYVVPWEKKI-YPTVNCQ 371
Cdd:smart00043  80 DQGE-KFCTAKVWEKPWENKIkLVEFKCT 107
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 144-237 4.23e-29

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 110.89  E-value: 4.23e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124056474  144 GCVHPISTQSPDLEPILRHGIQYFNNNTqHSSLFMLNEVKRAQRQVVAGLNFRITYSIVQTNCSKenFLFLTPDCKSLWN 223
Cdd:pfam00031   1 GGLSPIPDNSPELQEALDFALAEYNAKT-DNYYFELVEVKRAKSQVVAGTNYFIKVEVGETDCSK--SKKLLEDCPLLDE 77

                          90
                  ....*....|....
gi 124056474  224 GDTGECTDNAYIDI 237
Cdd:pfam00031  78 KWLGLCSAQVYKVP 91
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 266-370 1.64e-25

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 101.01  E-value: 1.64e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124056474 266 GCPRDIPTNSPELEETLTHTITKLNAENNATfYFKIDNVKKARVQVVAGKKYFIDFVARETTCSKESNEELTESCETKKL 345
Cdd:cd00042    1 GGPSDIPANDPEVQELADFAVAEYNKKSNDK-YLEFFKVLSAKSQVVAGTNYYITVEAGDTNCKKSSVPLDCPDCKLLEE 79

                         90       100
                 ....*....|....*....|....*.
gi 124056474 346 GQSLDCNAEVYVVPWEKKI-YPTVNC 370
Cdd:cd00042   80 GKKKFCTAKVWEKPWENFKeLLSFKC 105
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 24-114 1.12e-22

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 92.40  E-value: 1.12e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124056474   24 EEIDCNDKDLFKAVDAALKKYNSQNqSNNQFVLYRITEATKTVGSDTFYSFKYEIKEGDCPVqSGKTWQDCEYKDaaKAA 103
Cdd:pfam00031   4 SPIPDNSPELQEALDFALAEYNAKT-DNYYFELVEVKRAKSQVVAGTNYFIKVEVGETDCSK-SKKLLEDCPLLD--EKW 79

                          90
                  ....*....|.
gi 124056474  104 TGECTATVGKR 114
Cdd:pfam00031  80 LGLCSAQVYKV 90
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 142-249 5.52e-21

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 88.25  E-value: 5.52e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124056474   142 CLGCVHPISTQSPDLEPILRHGIQYFNNNTQHSSLFMLNEVKRAQRQVVAGLNFRITYSIVQTNCSKEnfLFLTPDCKSL 221
Cdd:smart00043   2 CLGGPSDVPPNDPEVQEAADFAVAEYNKKSNDKYELRVIKVVSAKSQVVAGTNYYLKVEVGETNCKKL--SVDLENCPFL 79

                           90       100
                   ....*....|....*....|....*....
gi 124056474   222 WNGDtGECTDNAY-IDIQLRIASFSQNCD 249
Cdd:smart00043  80 DQGE-KFCTAKVWeKPWENKIKLVEFKCT 107
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 144-248 1.35e-20

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 87.14  E-value: 1.35e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124056474 144 GCVHPISTQSPDLEPILRHGIQYFNNNTQHSSlFMLNEVKRAQRQVVAGLNFRITYSIVQTNCSKENFLFLTPDCKSLWN 223
Cdd:cd00042    1 GGPSDIPANDPEVQELADFAVAEYNKKSNDKY-LEFFKVLSAKSQVVAGTNYYITVEAGDTNCKKSSVPLDCPDCKLLEE 79

                         90       100
                 ....*....|....*....|....*.
gi 124056474 224 GDTGECTDNAYIDIQLR-IASFSQNC 248
Cdd:cd00042   80 GKKKFCTAKVWEKPWENfKELLSFKC 105
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 24-127 1.26e-18

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 81.71  E-value: 1.26e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124056474    24 EEIDCNDKDLFKAVDAALKKYNsqNQSNNQFVLYRIT--EATKTVGSDTFYSFKYEIKEGDCPVQSGKtWQDCEYKDAAK 101
Cdd:smart00043   7 SDVPPNDPEVQEAADFAVAEYN--KKSNDKYELRVIKvvSAKSQVVAGTNYYLKVEVGETNCKKLSVD-LENCPFLDQGE 83

                           90       100
                   ....*....|....*....|....*..
gi 124056474   102 aatGECTATVGKRS-STKFSVATQTCQ 127
Cdd:smart00043  84 ---KFCTAKVWEKPwENKIKLVEFKCT 107
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 24-126 3.43e-08

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 51.71  E-value: 3.43e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124056474  24 EEIDCNDKDLFKAVDAALKKYNSQNQSNNqFVLYRITEATKTVGSDTFYSFKYEIKEGDCPVQSGKTW-QDCEYKDAAKa 102
Cdd:cd00042    4 SDIPANDPEVQELADFAVAEYNKKSNDKY-LEFFKVLSAKSQVVAGTNYYITVEAGDTNCKKSSVPLDcPDCKLLEEGK- 81

                         90       100
                 ....*....|....*....|....*
gi 124056474 103 aTGECTATVGKRSSTKF-SVATQTC 126
Cdd:cd00042   82 -KKFCTAKVWEKPWENFkELLSFKC 105
ureE PRK13263
urease accessory protein UreE; Provisional
 423-469 3.40e-04

urease accessory protein UreE; Provisional


Pssm-ID: 237323  Cd Length: 206  Bit Score: 42.47  E-value: 3.40e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 124056474 423 QGHTRRHDwGHEkqrkHNLGHGHkHERDQGHGHQRGHGLGHGHEQQH 469
Cdd:PRK13263 165 QQVFHEHH-GHS----HSHSDHD-HDHDHDHDHVHGPGCGHGHHHHH 205
 
Name Accession Description Interval E-value
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 266-360 2.80e-31

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 117.05  E-value: 2.80e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124056474  266 GCPRDIPTNSPELEETLTHTITKLNAENNaTFYFKIDNVKKARVQVVAGKKYFIDFVARETTCSKesNEELTESCETKKL 345
Cdd:pfam00031   1 GGLSPIPDNSPELQEALDFALAEYNAKTD-NYYFELVEVKRAKSQVVAGTNYFIKVEVGETDCSK--SKKLLEDCPLLDE 77

                          90
                  ....*....|....*
gi 124056474  346 GQSLDCNAEVYVVPW 360
Cdd:pfam00031  78 KWLGLCSAQVYKVPW 92
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 264-371 2.36e-30

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 114.83  E-value: 2.36e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124056474   264 CVGCPRDIPTNSPELEETLTHTITKLNAENNATFYFKIDNVKKARVQVVAGKKYFIDFVARETTCSKESneELTESCETK 343
Cdd:smart00043   2 CLGGPSDVPPNDPEVQEAADFAVAEYNKKSNDKYELRVIKVVSAKSQVVAGTNYYLKVEVGETNCKKLS--VDLENCPFL 79

                           90       100
                   ....*....|....*....|....*....
gi 124056474   344 KLGQsLDCNAEVYVVPWEKKI-YPTVNCQ 371
Cdd:smart00043  80 DQGE-KFCTAKVWEKPWENKIkLVEFKCT 107
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 144-237 4.23e-29

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 110.89  E-value: 4.23e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124056474  144 GCVHPISTQSPDLEPILRHGIQYFNNNTqHSSLFMLNEVKRAQRQVVAGLNFRITYSIVQTNCSKenFLFLTPDCKSLWN 223
Cdd:pfam00031   1 GGLSPIPDNSPELQEALDFALAEYNAKT-DNYYFELVEVKRAKSQVVAGTNYFIKVEVGETDCSK--SKKLLEDCPLLDE 77

                          90
                  ....*....|....
gi 124056474  224 GDTGECTDNAYIDI 237
Cdd:pfam00031  78 KWLGLCSAQVYKVP 91
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 266-370 1.64e-25

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 101.01  E-value: 1.64e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124056474 266 GCPRDIPTNSPELEETLTHTITKLNAENNATfYFKIDNVKKARVQVVAGKKYFIDFVARETTCSKESNEELTESCETKKL 345
Cdd:cd00042    1 GGPSDIPANDPEVQELADFAVAEYNKKSNDK-YLEFFKVLSAKSQVVAGTNYYITVEAGDTNCKKSSVPLDCPDCKLLEE 79

                         90       100
                 ....*....|....*....|....*.
gi 124056474 346 GQSLDCNAEVYVVPWEKKI-YPTVNC 370
Cdd:cd00042   80 GKKKFCTAKVWEKPWENFKeLLSFKC 105
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 24-114 1.12e-22

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 92.40  E-value: 1.12e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124056474   24 EEIDCNDKDLFKAVDAALKKYNSQNqSNNQFVLYRITEATKTVGSDTFYSFKYEIKEGDCPVqSGKTWQDCEYKDaaKAA 103
Cdd:pfam00031   4 SPIPDNSPELQEALDFALAEYNAKT-DNYYFELVEVKRAKSQVVAGTNYFIKVEVGETDCSK-SKKLLEDCPLLD--EKW 79

                          90
                  ....*....|.
gi 124056474  104 TGECTATVGKR 114
Cdd:pfam00031  80 LGLCSAQVYKV 90
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 142-249 5.52e-21

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 88.25  E-value: 5.52e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124056474   142 CLGCVHPISTQSPDLEPILRHGIQYFNNNTQHSSLFMLNEVKRAQRQVVAGLNFRITYSIVQTNCSKEnfLFLTPDCKSL 221
Cdd:smart00043   2 CLGGPSDVPPNDPEVQEAADFAVAEYNKKSNDKYELRVIKVVSAKSQVVAGTNYYLKVEVGETNCKKL--SVDLENCPFL 79

                           90       100
                   ....*....|....*....|....*....
gi 124056474   222 WNGDtGECTDNAY-IDIQLRIASFSQNCD 249
Cdd:smart00043  80 DQGE-KFCTAKVWeKPWENKIKLVEFKCT 107
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 144-248 1.35e-20

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 87.14  E-value: 1.35e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124056474 144 GCVHPISTQSPDLEPILRHGIQYFNNNTQHSSlFMLNEVKRAQRQVVAGLNFRITYSIVQTNCSKENFLFLTPDCKSLWN 223
Cdd:cd00042    1 GGPSDIPANDPEVQELADFAVAEYNKKSNDKY-LEFFKVLSAKSQVVAGTNYYITVEAGDTNCKKSSVPLDCPDCKLLEE 79

                         90       100
                 ....*....|....*....|....*.
gi 124056474 224 GDTGECTDNAYIDIQLR-IASFSQNC 248
Cdd:cd00042   80 GKKKFCTAKVWEKPWENfKELLSFKC 105
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 24-127 1.26e-18

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 81.71  E-value: 1.26e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124056474    24 EEIDCNDKDLFKAVDAALKKYNsqNQSNNQFVLYRIT--EATKTVGSDTFYSFKYEIKEGDCPVQSGKtWQDCEYKDAAK 101
Cdd:smart00043   7 SDVPPNDPEVQEAADFAVAEYN--KKSNDKYELRVIKvvSAKSQVVAGTNYYLKVEVGETNCKKLSVD-LENCPFLDQGE 83

                           90       100
                   ....*....|....*....|....*..
gi 124056474   102 aatGECTATVGKRS-STKFSVATQTCQ 127
Cdd:smart00043  84 ---KFCTAKVWEKPwENKIKLVEFKCT 107
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 24-126 3.43e-08

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 51.71  E-value: 3.43e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124056474  24 EEIDCNDKDLFKAVDAALKKYNSQNQSNNqFVLYRITEATKTVGSDTFYSFKYEIKEGDCPVQSGKTW-QDCEYKDAAKa 102
Cdd:cd00042    4 SDIPANDPEVQELADFAVAEYNKKSNDKY-LEFFKVLSAKSQVVAGTNYYITVEAGDTNCKKSSVPLDcPDCKLLEEGK- 81

                         90       100
                 ....*....|....*....|....*
gi 124056474 103 aTGECTATVGKRSSTKF-SVATQTC 126
Cdd:cd00042   82 -KKFCTAKVWEKPWENFkELLSFKC 105
ureE PRK13263
urease accessory protein UreE; Provisional
 423-469 3.40e-04

urease accessory protein UreE; Provisional


Pssm-ID: 237323  Cd Length: 206  Bit Score: 42.47  E-value: 3.40e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 124056474 423 QGHTRRHDwGHEkqrkHNLGHGHkHERDQGHGHQRGHGLGHGHEQQH 469
Cdd:PRK13263 165 QQVFHEHH-GHS----HSHSDHD-HDHDHDHDHVHGPGCGHGHHHHH 205
ureE PRK13263
urease accessory protein UreE; Provisional
 424-475 2.26e-03

urease accessory protein UreE; Provisional


Pssm-ID: 237323  Cd Length: 206  Bit Score: 39.77  E-value: 2.26e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 124056474 424 GHTRRHDWGHEK-----QRKHNLGHGHKHerDQGHGHQrGHGLGHGHEQQHGLGHGH 475
Cdd:PRK13263 148 GHRHGHDATFAEdyalaQQVFHEHHGHSH--SHSDHDH-DHDHDHDHVHGPGCGHGH 201
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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