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Conserved domains on  [gi|1243938446|ref|NP_001342422|]
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exostosin-like 1 isoform 2 [Mus musculus]

Protein Classification

Glyco_transf_64 domain-containing protein( domain architecture ID 10558028)

Glyco_transf_64 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Glyco_transf_64 pfam09258
Glycosyl transferase family 64 domain; Members of this family catalyze the transfer reaction ...
 143-379 3.76e-125

Glycosyl transferase family 64 domain; Members of this family catalyze the transfer reaction of N-acetylglucosamine and N-acetylgalactosamine from the respective UDP-sugars to the non-reducing end of [glucuronic acid]beta 1-3[galactose]beta 1-O-naphthalenemethanol, an acceptor substrate analog of the natural common linker of various glycosylaminoglycans. They are also required for the biosynthesis of heparan-sulphate.


:

Pssm-ID: 430488  Cd Length: 241  Bit Score: 360.84  E-value: 3.76e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243938446 143 FSAVIWVGAS-GESLLKLIQEVAGSRHCAQILILWNSEKLPPD--RWPETAVPLTVIKGHRKV-SNRFFPYSNISTNVIL 218
Cdd:pfam09258   1 FTAVINTYYSrIDLLLKLLQRYAGSPHLAKIIVLWNNPKPPPElsRWPGTGVPVTVIRQKRNSlNNRFLPYPEIETDAVL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243938446 219 SLDAQSTLSTSEVDFAFVVWQSFPERMVGFLSGSHFWDEAQGGWGYRTGMTNEFSMVLTTAAFYHRYYHTLFTHSLPKAL 298
Cdd:pfam09258  81 SLDDDILLSTDEIDFAFRVWRSFPDRIVGFPPRSHFWDLSSGRWGYTSEWTNEYSMVLTGAAFYHRYYLYLYTHSLPKSL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243938446 299 RTIADETPTCVDVLMNFLVATVTKLPPIKVPYGRQHPEAVPMDSGDPRPVPEPQPLDQDCINRLAAGFGHMPLVSSQVRL 378
Cdd:pfam09258 161 RTLVDETQNCEDILMNFLVANVTRKPPVKVTQRKQFKEGKNSGKVGLSSRPGHFLQRSKCINKFAAVFGYMPLVYSQIRL 240


                  .
gi 1243938446 379 D 379
Cdd:pfam09258 241 D 241
RXYLT1-like super family cl20239
ribitol-5-phosphate xylosyltransferase 1, and related proteins; Ribitol-5-phosphate ...
 15-59 3.14e-12

ribitol-5-phosphate xylosyltransferase 1, and related proteins; Ribitol-5-phosphate xylosyltransferase 1 (RXYLT1, also known as transmembrane protein 5, TMEM5) is a transmembrane protein which acts as a UDP-d-xylose:ribitol-5-phosphate beta1,4-xylosyltransferase in the biosynthetic pathway of O-mannosyl glycan. RXYLT1 catalyzes the transfer of UDP-D-xylose to ribitol 5-phosphate (Rbo5P) to form the Xylbeta1-4Rbo5P linkage on O-mannosyl glycan. O-mannosyl glycan is present in a number of glycoproteins, including alpha-dystroglycan. The TMEM5 gene has been associated with alpha-dystroglycanopathies, a diverse group of neuromuscular disorders caused by aberrant O-mannosylation of alpha-dystroglycan.


The actual alignment was detected with superfamily member pfam03016:

Pssm-ID: 473306  Cd Length: 290  Bit Score: 66.68  E-value: 3.14e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1243938446  15 QAGCIPVLLSPRWELPFSEVIDWTKAAIIADERLPLQVLAALREM 59
Cdd:pfam03016 246 LAGCIPVIISDGWELPFADVIDWRKFSVFVPENDIPELKSILRSL 290
 
Name Accession Description Interval E-value
Glyco_transf_64 pfam09258
Glycosyl transferase family 64 domain; Members of this family catalyze the transfer reaction ...
 143-379 3.76e-125

Glycosyl transferase family 64 domain; Members of this family catalyze the transfer reaction of N-acetylglucosamine and N-acetylgalactosamine from the respective UDP-sugars to the non-reducing end of [glucuronic acid]beta 1-3[galactose]beta 1-O-naphthalenemethanol, an acceptor substrate analog of the natural common linker of various glycosylaminoglycans. They are also required for the biosynthesis of heparan-sulphate.


Pssm-ID: 430488  Cd Length: 241  Bit Score: 360.84  E-value: 3.76e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243938446 143 FSAVIWVGAS-GESLLKLIQEVAGSRHCAQILILWNSEKLPPD--RWPETAVPLTVIKGHRKV-SNRFFPYSNISTNVIL 218
Cdd:pfam09258   1 FTAVINTYYSrIDLLLKLLQRYAGSPHLAKIIVLWNNPKPPPElsRWPGTGVPVTVIRQKRNSlNNRFLPYPEIETDAVL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243938446 219 SLDAQSTLSTSEVDFAFVVWQSFPERMVGFLSGSHFWDEAQGGWGYRTGMTNEFSMVLTTAAFYHRYYHTLFTHSLPKAL 298
Cdd:pfam09258  81 SLDDDILLSTDEIDFAFRVWRSFPDRIVGFPPRSHFWDLSSGRWGYTSEWTNEYSMVLTGAAFYHRYYLYLYTHSLPKSL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243938446 299 RTIADETPTCVDVLMNFLVATVTKLPPIKVPYGRQHPEAVPMDSGDPRPVPEPQPLDQDCINRLAAGFGHMPLVSSQVRL 378
Cdd:pfam09258 161 RTLVDETQNCEDILMNFLVANVTRKPPVKVTQRKQFKEGKNSGKVGLSSRPGHFLQRSKCINKFAAVFGYMPLVYSQIRL 240


                  .
gi 1243938446 379 D 379
Cdd:pfam09258 241 D 241
Exostosin pfam03016
Exostosin family; The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on ...
 15-59 3.14e-12

Exostosin family; The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear.


Pssm-ID: 397245  Cd Length: 290  Bit Score: 66.68  E-value: 3.14e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1243938446  15 QAGCIPVLLSPRWELPFSEVIDWTKAAIIADERLPLQVLAALREM 59
Cdd:pfam03016 246 LAGCIPVIISDGWELPFADVIDWRKFSVFVPENDIPELKSILRSL 290
 
Name Accession Description Interval E-value
Glyco_transf_64 pfam09258
Glycosyl transferase family 64 domain; Members of this family catalyze the transfer reaction ...
 143-379 3.76e-125

Glycosyl transferase family 64 domain; Members of this family catalyze the transfer reaction of N-acetylglucosamine and N-acetylgalactosamine from the respective UDP-sugars to the non-reducing end of [glucuronic acid]beta 1-3[galactose]beta 1-O-naphthalenemethanol, an acceptor substrate analog of the natural common linker of various glycosylaminoglycans. They are also required for the biosynthesis of heparan-sulphate.


Pssm-ID: 430488  Cd Length: 241  Bit Score: 360.84  E-value: 3.76e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243938446 143 FSAVIWVGAS-GESLLKLIQEVAGSRHCAQILILWNSEKLPPD--RWPETAVPLTVIKGHRKV-SNRFFPYSNISTNVIL 218
Cdd:pfam09258   1 FTAVINTYYSrIDLLLKLLQRYAGSPHLAKIIVLWNNPKPPPElsRWPGTGVPVTVIRQKRNSlNNRFLPYPEIETDAVL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243938446 219 SLDAQSTLSTSEVDFAFVVWQSFPERMVGFLSGSHFWDEAQGGWGYRTGMTNEFSMVLTTAAFYHRYYHTLFTHSLPKAL 298
Cdd:pfam09258  81 SLDDDILLSTDEIDFAFRVWRSFPDRIVGFPPRSHFWDLSSGRWGYTSEWTNEYSMVLTGAAFYHRYYLYLYTHSLPKSL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243938446 299 RTIADETPTCVDVLMNFLVATVTKLPPIKVPYGRQHPEAVPMDSGDPRPVPEPQPLDQDCINRLAAGFGHMPLVSSQVRL 378
Cdd:pfam09258 161 RTLVDETQNCEDILMNFLVANVTRKPPVKVTQRKQFKEGKNSGKVGLSSRPGHFLQRSKCINKFAAVFGYMPLVYSQIRL 240


                  .
gi 1243938446 379 D 379
Cdd:pfam09258 241 D 241
Exostosin pfam03016
Exostosin family; The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on ...
 15-59 3.14e-12

Exostosin family; The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear.


Pssm-ID: 397245  Cd Length: 290  Bit Score: 66.68  E-value: 3.14e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1243938446  15 QAGCIPVLLSPRWELPFSEVIDWTKAAIIADERLPLQVLAALREM 59
Cdd:pfam03016 246 LAGCIPVIISDGWELPFADVIDWRKFSVFVPENDIPELKSILRSL 290
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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