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Conserved domains on  [gi|1249009330|ref|XP_007250842|]
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transcription factor GATA-5 isoform X1 [Astyanax mexicanus]

Protein Classification

GATA-type transcription factor( domain architecture ID 11786012)

GATA-type transcription factor binds to the DNA consensus sequence [AT]GATA[AG] and may function as a transcription factor/regulator

CATH:  3.30.50.10
Gene Ontology:  GO:0003700|GO:0006357|GO:0006355|GO:0008270|GO:0043565
PubMed:  31574210
SCOP:  4003617

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GATA-N super family cl25837
GATA-type transcription activator, N-terminal; GATA transcription factors mediate cell ...
 1-173 9.51e-28

GATA-type transcription activator, N-terminal; GATA transcription factors mediate cell differentiation in a diverse range of tissues. Mutation are often associated with certain congenital human disorders. The six classical vertebrate GATA proteins, GATA-1 to GATA-6, are highly homologous and have two tandem zinc fingers. The classical GATA transcription factors function transcription activators. In lower metazoans GATA proteins carry a single canonical zinc finger. This family represents the N-terminal domain of the family of GATA transcription activators.


The actual alignment was detected with superfamily member pfam05349:

Pssm-ID: 461628 [Multi-domain]  Cd Length: 174  Bit Score: 107.52  E-value: 9.51e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249009330   1 MYSSLAISSNPSP--YAHDSAGYIHPSASSPVYMASGRVPAVLQPLSYLQPCEPAHAHqthaLSAHHHHAWPQTAADGSA 78
Cdd:pfam05349   1 MYQSLALAANHGQaaYDHDSGGFLHSAASSPVYVPTTRVPSMLPTLPYLQGCGSSQQS----HPVSSHSGWAQAGAESSS 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249009330  79 FSPGSPHPAHP---------HSHPHAPPAFSYASSPPASSADQYgpgggtagggGALVRSSSYSSPY--AAYMSPDV-TS 146
Cdd:pfam05349  77 YNPGSPHPSPRfsyshsppgSNGTSRDAAYQSPLLISAGGREQY----------GALGRPLGGSYPSpyPAYVSPEMaPS 146

                         170       180
                  ....*....|....*....|....*...
gi 1249009330 147 WSPGHFDGSMI-GFQGRQGALAGRRSSL 173
Cdd:pfam05349 147 WTAGPFDSSVLhSLQGRGAPLPGRRPNL 174
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 241-291 7.93e-20

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


:

Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 82.04  E-value: 7.93e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1249009330 241 CTNCHTSTTTLWRRN-AEGEPVCNACGLYMKLHGVPRPLAMKKES-IQTRKRK 291
Cdd:cd00202     2 CSNCGTTTTPLWRRGpSGGSTLCNACGLYWKKHGVMRPLSKRKKDqIKRRNRK 54
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 185-236 1.12e-18

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


:

Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 78.95  E-value: 1.12e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1249009330 185 ECVNCGSISTPLWRRDG-TGHYLCNACGLYHKMNGINRPLIKPQKRLQNTSRR 236
Cdd:cd00202     1 ACSNCGTTTTPLWRRGPsGGSTLCNACGLYWKKHGVMRPLSKRKKDQIKRRNR 53
 
Name Accession Description Interval E-value
GATA-N pfam05349
GATA-type transcription activator, N-terminal; GATA transcription factors mediate cell ...
 1-173 9.51e-28

GATA-type transcription activator, N-terminal; GATA transcription factors mediate cell differentiation in a diverse range of tissues. Mutation are often associated with certain congenital human disorders. The six classical vertebrate GATA proteins, GATA-1 to GATA-6, are highly homologous and have two tandem zinc fingers. The classical GATA transcription factors function transcription activators. In lower metazoans GATA proteins carry a single canonical zinc finger. This family represents the N-terminal domain of the family of GATA transcription activators.


Pssm-ID: 461628 [Multi-domain]  Cd Length: 174  Bit Score: 107.52  E-value: 9.51e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249009330   1 MYSSLAISSNPSP--YAHDSAGYIHPSASSPVYMASGRVPAVLQPLSYLQPCEPAHAHqthaLSAHHHHAWPQTAADGSA 78
Cdd:pfam05349   1 MYQSLALAANHGQaaYDHDSGGFLHSAASSPVYVPTTRVPSMLPTLPYLQGCGSSQQS----HPVSSHSGWAQAGAESSS 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249009330  79 FSPGSPHPAHP---------HSHPHAPPAFSYASSPPASSADQYgpgggtagggGALVRSSSYSSPY--AAYMSPDV-TS 146
Cdd:pfam05349  77 YNPGSPHPSPRfsyshsppgSNGTSRDAAYQSPLLISAGGREQY----------GALGRPLGGSYPSpyPAYVSPEMaPS 146

                         170       180
                  ....*....|....*....|....*...
gi 1249009330 147 WSPGHFDGSMI-GFQGRQGALAGRRSSL 173
Cdd:pfam05349 147 WTAGPFDSSVLhSLQGRGAPLPGRRPNL 174
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 241-291 7.93e-20

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 82.04  E-value: 7.93e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1249009330 241 CTNCHTSTTTLWRRN-AEGEPVCNACGLYMKLHGVPRPLAMKKES-IQTRKRK 291
Cdd:cd00202     2 CSNCGTTTTPLWRRGpSGGSTLCNACGLYWKKHGVMRPLSKRKKDqIKRRNRK 54
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 185-236 1.12e-18

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 78.95  E-value: 1.12e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1249009330 185 ECVNCGSISTPLWRRDG-TGHYLCNACGLYHKMNGINRPLIKPQKRLQNTSRR 236
Cdd:cd00202     1 ACSNCGTTTTPLWRRGPsGGSTLCNACGLYWKKHGVMRPLSKRKKDQIKRRNR 53
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
236-285 6.08e-17

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 73.99  E-value: 6.08e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1249009330  236 RAGLCCTNCHTSTTTLWRRNAEGE-PVCNACGLYMKLHGVP-RPLAMKKESI 285
Cdd:smart00401   1 GSGRSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGGLkRPLSLKKDGI 52
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
182-228 7.53e-14

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 65.52  E-value: 7.53e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1249009330  182 EGRECVNCGSISTPLWRRDGTGH-YLCNACGLYHKMNGINRPLIKPQK 228
Cdd:smart00401   2 SGRSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGGLKRPLSLKK 49
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 241-275 6.75e-13

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 62.34  E-value: 6.75e-13
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1249009330 241 CTNCHTSTTTLWRRNAEGEP-VCNACGLYMKLHGVP 275
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKKGLK 36
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 186-218 8.77e-12

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 59.25  E-value: 8.77e-12
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1249009330 186 CVNCGSISTPLWRRDGTGHY-LCNACGLYHKMNG 218
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKKG 34
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
186-296 2.90e-08

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 55.26  E-value: 2.90e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249009330 186 CVNCGSISTPLWRRD-----GTGHYLCNACGLYHKMNGINRPLIKpQKRLQNTSRRAGLCCTNC-HTSTTTLWRRNAEGE 259
Cdd:COG5641   161 CSNCKTTSTPLWRRAssessLPGNNLCNACGLYLKLHGSPRAPIS-LKSDSIKSRSSRSSHNNNdSNGENANTESIGNSS 239

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1249009330 260 PVCNACGLYMKLHGvpRPLAMKKESIQTRKRKPKMPK 296
Cdd:COG5641   240 ASKLTKSWEERPQG--RQLLSDAGSLSPRSNNPKSPL 274
 
Name Accession Description Interval E-value
GATA-N pfam05349
GATA-type transcription activator, N-terminal; GATA transcription factors mediate cell ...
 1-173 9.51e-28

GATA-type transcription activator, N-terminal; GATA transcription factors mediate cell differentiation in a diverse range of tissues. Mutation are often associated with certain congenital human disorders. The six classical vertebrate GATA proteins, GATA-1 to GATA-6, are highly homologous and have two tandem zinc fingers. The classical GATA transcription factors function transcription activators. In lower metazoans GATA proteins carry a single canonical zinc finger. This family represents the N-terminal domain of the family of GATA transcription activators.


Pssm-ID: 461628 [Multi-domain]  Cd Length: 174  Bit Score: 107.52  E-value: 9.51e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249009330   1 MYSSLAISSNPSP--YAHDSAGYIHPSASSPVYMASGRVPAVLQPLSYLQPCEPAHAHqthaLSAHHHHAWPQTAADGSA 78
Cdd:pfam05349   1 MYQSLALAANHGQaaYDHDSGGFLHSAASSPVYVPTTRVPSMLPTLPYLQGCGSSQQS----HPVSSHSGWAQAGAESSS 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249009330  79 FSPGSPHPAHP---------HSHPHAPPAFSYASSPPASSADQYgpgggtagggGALVRSSSYSSPY--AAYMSPDV-TS 146
Cdd:pfam05349  77 YNPGSPHPSPRfsyshsppgSNGTSRDAAYQSPLLISAGGREQY----------GALGRPLGGSYPSpyPAYVSPEMaPS 146

                         170       180
                  ....*....|....*....|....*...
gi 1249009330 147 WSPGHFDGSMI-GFQGRQGALAGRRSSL 173
Cdd:pfam05349 147 WTAGPFDSSVLhSLQGRGAPLPGRRPNL 174
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 241-291 7.93e-20

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 82.04  E-value: 7.93e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1249009330 241 CTNCHTSTTTLWRRN-AEGEPVCNACGLYMKLHGVPRPLAMKKES-IQTRKRK 291
Cdd:cd00202     2 CSNCGTTTTPLWRRGpSGGSTLCNACGLYWKKHGVMRPLSKRKKDqIKRRNRK 54
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 185-236 1.12e-18

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 78.95  E-value: 1.12e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1249009330 185 ECVNCGSISTPLWRRDG-TGHYLCNACGLYHKMNGINRPLIKPQKRLQNTSRR 236
Cdd:cd00202     1 ACSNCGTTTTPLWRRGPsGGSTLCNACGLYWKKHGVMRPLSKRKKDQIKRRNR 53
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
236-285 6.08e-17

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 73.99  E-value: 6.08e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1249009330  236 RAGLCCTNCHTSTTTLWRRNAEGE-PVCNACGLYMKLHGVP-RPLAMKKESI 285
Cdd:smart00401   1 GSGRSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGGLkRPLSLKKDGI 52
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
182-228 7.53e-14

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 65.52  E-value: 7.53e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1249009330  182 EGRECVNCGSISTPLWRRDGTGH-YLCNACGLYHKMNGINRPLIKPQK 228
Cdd:smart00401   2 SGRSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGGLKRPLSLKK 49
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 241-275 6.75e-13

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 62.34  E-value: 6.75e-13
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1249009330 241 CTNCHTSTTTLWRRNAEGEP-VCNACGLYMKLHGVP 275
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKKGLK 36
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 186-218 8.77e-12

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 59.25  E-value: 8.77e-12
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1249009330 186 CVNCGSISTPLWRRDGTGHY-LCNACGLYHKMNG 218
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKKG 34
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
186-296 2.90e-08

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 55.26  E-value: 2.90e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249009330 186 CVNCGSISTPLWRRD-----GTGHYLCNACGLYHKMNGINRPLIKpQKRLQNTSRRAGLCCTNC-HTSTTTLWRRNAEGE 259
Cdd:COG5641   161 CSNCKTTSTPLWRRAssessLPGNNLCNACGLYLKLHGSPRAPIS-LKSDSIKSRSSRSSHNNNdSNGENANTESIGNSS 239

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1249009330 260 PVCNACGLYMKLHGvpRPLAMKKESIQTRKRKPKMPK 296
Cdd:COG5641   240 ASKLTKSWEERPQG--RQLLSDAGSLSPRSNNPKSPL 274
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
188-381 1.67e-06

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 49.87  E-value: 1.67e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249009330 188 NCGSISTPLWRR-DGTGHYLCNACGLYHKMNGINRPLikPQKRLQNTsRRAGLCCTNCHTSTTTLWRrnaEGEPVCNACG 266
Cdd:COG5641   303 LTTSTATPLWRRtSDKSSFSCNASGSALKPPGSKRPL--LPKPDPNS-KRSNATCMNCSSTPTNKIL---SPPTTSNSPG 376

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249009330 267 LYMKLHGVPRPLAMKKESIqtrKRKPKMPKTKPtsgssvsgttSPQSQPISENAS-TIKSEPNIAASPYAGQTVVSVTQA 345
Cdd:COG5641   377 AQVKLPNQTRSTGATKKKI---TRRRMNSGKIP----------ALSSSMKNPVPKeFSPLIPQSTESETPSQSKSSLTSK 443

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1249009330 346 STQISSTSSGQVDIKYEDY--AFTPTSIAQQNSWCALS 381
Cdd:COG5641   444 LEEFESLSLLKSVSSMMNLenDLSSSHDSALFDKLDDS 481
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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