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Conserved domains on  [gi|12837833|dbj|BAB23968|]
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unnamed protein product [Mus musculus]

Protein Classification

EF-hand domain-containing protein( domain architecture ID 12144783)

EF-hand (EFh) domain-containing protein may be involved in binding intracellular calcium and in calcium signal transduction

CATH:  1.10.238.10
Gene Ontology:  GO:0005509
PubMed:  2479149|10191494

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EF-hand_7 pfam13499
EF-hand domain pair;
107-173 1.46e-08

EF-hand domain pair;


:

Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 49.17  E-value: 1.46e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 12837833   107 KANYAFKIYDFNTDNFICKEDLEMTLARLTKSELEEDEVVlvcDKVIEEADLDGDGKLGFADFEDMI 173
Cdd:pfam13499   3 KLKEAFKLLDSDGDGYLDVEELKKLLRKLEEGEPLSDEEV---EELFKEFDLDKDGRISFEEFLELY 66
 
Name Accession Description Interval E-value
EF-hand_7 pfam13499
EF-hand domain pair;
107-173 1.46e-08

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 49.17  E-value: 1.46e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 12837833   107 KANYAFKIYDFNTDNFICKEDLEMTLARLTKSELEEDEVVlvcDKVIEEADLDGDGKLGFADFEDMI 173
Cdd:pfam13499   3 KLKEAFKLLDSDGDGYLDVEELKKLLRKLEEGEPLSDEEV---EELFKEFDLDKDGRISFEEFLELY 66
PTZ00184 PTZ00184
calmodulin; Provisional
 62-173 3.80e-08

calmodulin; Provisional


Pssm-ID: 185504 [Multi-domain]  Cd Length: 149  Bit Score: 50.15  E-value: 3.80e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12837833   62 MPELRENPFKERIVEAFSE---DGEGNLTFNDFVDMFSVLCESAPRELKANYAFKIYDFNTDNFICKEDLEMTLARLTKs 138
Cdd:PTZ00184  37 MRSLGQNPTEAELQDMINEvdaDGNGTIDFPEFLTLMARKMKDTDSEEEIKEAFKVFDRDGNGFISAAELRHVMTNLGE- 115

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 12837833  139 ELEEDEVvlvcDKVIEEADLDGDGKLGFADFEDMI 173
Cdd:PTZ00184 116 KLTDEEV----DEMIREADVDGDGQINYEEFVKMM 146
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 107-174 5.34e-07

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 44.85  E-value: 5.34e-07
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 12837833 107 KANYAFKIYDFNTDNFICKEDLEMTLARLTKSELEEDevvlvCDKVIEEADLDGDGKLGFADFEDMIA 174
Cdd:cd00051   1 ELREAFRLFDKDGDGTISADELKAALKSLGEGLSEEE-----IDEMIREVDKDGDGKIDFEEFLELMA 63
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
72-169 6.22e-04

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 38.23  E-value: 6.22e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12837833  72 ERIVEAFSEDGEGNLTFNDFVDMFSVLCESAPRElKANYAFKIYDFNTDNFICKEDLEmtlARLTKSELEEDEVvlvcDK 151
Cdd:COG5126  36 ATLFSEADTDGDGRISREEFVAGMESLFEATVEP-FARAAFDLLDTDGDGKISADEFR---RLLTALGVSEEEA----DE 107

                        90
                ....*....|....*...
gi 12837833 152 VIEEADLDGDGKLGFADF 169
Cdd:COG5126 108 LFARLDTDGDGKISFEEF 125
 
Name Accession Description Interval E-value
EF-hand_7 pfam13499
EF-hand domain pair;
107-173 1.46e-08

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 49.17  E-value: 1.46e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 12837833   107 KANYAFKIYDFNTDNFICKEDLEMTLARLTKSELEEDEVVlvcDKVIEEADLDGDGKLGFADFEDMI 173
Cdd:pfam13499   3 KLKEAFKLLDSDGDGYLDVEELKKLLRKLEEGEPLSDEEV---EELFKEFDLDKDGRISFEEFLELY 66
PTZ00184 PTZ00184
calmodulin; Provisional
 62-173 3.80e-08

calmodulin; Provisional


Pssm-ID: 185504 [Multi-domain]  Cd Length: 149  Bit Score: 50.15  E-value: 3.80e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12837833   62 MPELRENPFKERIVEAFSE---DGEGNLTFNDFVDMFSVLCESAPRELKANYAFKIYDFNTDNFICKEDLEMTLARLTKs 138
Cdd:PTZ00184  37 MRSLGQNPTEAELQDMINEvdaDGNGTIDFPEFLTLMARKMKDTDSEEEIKEAFKVFDRDGNGFISAAELRHVMTNLGE- 115

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 12837833  139 ELEEDEVvlvcDKVIEEADLDGDGKLGFADFEDMI 173
Cdd:PTZ00184 116 KLTDEEV----DEMIREADVDGDGQINYEEFVKMM 146
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 107-174 5.34e-07

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 44.85  E-value: 5.34e-07
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 12837833 107 KANYAFKIYDFNTDNFICKEDLEMTLARLTKSELEEDevvlvCDKVIEEADLDGDGKLGFADFEDMIA 174
Cdd:cd00051   1 ELREAFRLFDKDGDGTISADELKAALKSLGEGLSEEE-----IDEMIREVDKDGDGKIDFEEFLELMA 63
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
72-169 6.22e-04

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 38.23  E-value: 6.22e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12837833  72 ERIVEAFSEDGEGNLTFNDFVDMFSVLCESAPRElKANYAFKIYDFNTDNFICKEDLEmtlARLTKSELEEDEVvlvcDK 151
Cdd:COG5126  36 ATLFSEADTDGDGRISREEFVAGMESLFEATVEP-FARAAFDLLDTDGDGKISADEFR---RLLTALGVSEEEA----DE 107

                        90
                ....*....|....*...
gi 12837833 152 VIEEADLDGDGKLGFADF 169
Cdd:COG5126 108 LFARLDTDGDGKISFEEF 125
PTZ00183 PTZ00183
centrin; Provisional
 62-177 1.44e-03

centrin; Provisional


Pssm-ID: 185503 [Multi-domain]  Cd Length: 158  Bit Score: 37.36  E-value: 1.44e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12837833   62 MPELRENPFKERIVEAFSE---DGEGNLTFNDFVDMFSV-LCESAPRElKANYAFKIYDFNTDNFICKEDLEMTLARL-- 135
Cdd:PTZ00183  43 MRSLGFEPKKEEIKQMIADvdkDGSGKIDFEEFLDIMTKkLGERDPRE-EILKAFRLFDDDKTGKISLKNLKRVAKELge 121

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 12837833  136 --TKSELEEdevvlvcdkVIEEADLDGDGKLGFADFEDMIAKAP 177
Cdd:PTZ00183 122 tiTDEELQE---------MIDEADRNGDGEISEEEFYRIMKKTN 156
EFh_calglandulin_like cd16252
EF-hand, calcium binding motif, found in uncharacterized calglandulin-like proteins; The ...
 84-175 4.89e-03

EF-hand, calcium binding motif, found in uncharacterized calglandulin-like proteins; The family corresponds to a group of uncharacterized calglandulin-like proteins. Although their biological function remain unclear, they show high sequence similarity with human calglandulin-like protein GAGLP, which is an ortholog of calglandulin from the venom glands of Bothrops insularis snake. Both GAGLP and calglandulin are putative Ca2+-binding proteins with four EF-hand motifs. However, members in this family contain only three EF-hand motifs. In this point, they may belong to the parvalbumin-like EF-hand family, which is characterized by the presence of three consecutive EF-hand motifs (helix-loop-helix).


Pssm-ID: 319995 [Multi-domain]  Cd Length: 106  Bit Score: 35.20  E-value: 4.89e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12837833  84 GNLTFNDFVDMFSVLCESAPRELKANYAFKIYDFNTDNFICKEDLEMTLARLTKS----ELEEDEVvlvcDKVIEEADLD 159
Cdd:cd16252  15 GSFNYSKFFEYMQKFQTSEQQEEAIRKAFQMLDKDKSGFIEWNEIKYILSTVPSSmpvaPLSDEEA----EAMIQAADTD 90

                        90
                ....*....|....*.
gi 12837833 160 GDGKLGFADFEDMIAK 175
Cdd:cd16252  91 GDGRIDFQEFSDMVKK 106
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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