|
Name |
Accession |
Description |
Interval |
E-value |
| MCM8 |
cd17759 |
DNA helicase Mcm8; Mcm8 plays an important role homologous recombination repair. It forms a ... |
54-396 |
0e+00 |
|
DNA helicase Mcm8; Mcm8 plays an important role homologous recombination repair. It forms a complex with Mcm9 that is required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).
Pssm-ID: 350665 [Multi-domain] Cd Length: 289 Bit Score: 533.26 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 54 LVVNSLCPVIFGHELVKAGLTLALFGGSQKYADDKNRIPIRGDPHVLIVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTS 133
Cdd:cd17759 1 LIVNSLCPAIYGHELVKAGLLLSLFGGKQKYADDKNRIPIRGDPHVLIVGDPGLGKSQMLQAACNIAPRGVYVCGNTTTT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 134 SGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQHQALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVG 213
Cdd:cd17759 81 SGLTVTLTKDGRSGDFALEAGALVLGDQGICGIDEFDKMGSQHQALLEAMEQQSVSLAKAGVVCSLPARTSVIAAANPVG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 214 GHYNKARTVSENLKMGSALLSRFDLVFILLDTPNEQHDHLLSEHviairagkqkavssatvtrvlsqdsntsvlevvsek 293
Cdd:cd17759 161 GHYNKGKTVSENLKMGPALLSRFDLVFILLDTPSEEHDHLLSEH------------------------------------ 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 294 plserlkvapgeqtdpipHQLLRKYIGYARQYVHPRLSTDAAQALQDFYLELRKQSQRVGSSPITTRQLESLIRLTEARA 373
Cdd:cd17759 205 ------------------HQLLRKYISYARQYVNPVLSKDASEALQEFYLELRKQNQLADSSPITTRQLESLIRLTEARA 266
|
330 340
....*....|....*....|...
gi 12845756 374 RLELREEATREDAEDIIEIMKHS 396
Cdd:cd17759 267 RLELREEATKEDAEDVIEIMKES 289
|
|
| Mcm2 |
COG1241 |
DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and ... |
2-486 |
3.09e-146 |
|
DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair];
Pssm-ID: 440854 [Multi-domain] Cd Length: 682 Bit Score: 434.23 E-value: 3.09e-146
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 2 FLLYIEANSVSnskgPKAQTAEDgckhgtlMEFSLKDLYAIREIQAEENLLKLVVNSLCPVIFGHELVKAGLTLALFGGS 81
Cdd:COG1241 234 FDLYLEANSIE----VEEKEFEE-------IEITEEDEEKIKELSKDPDIYEKIIASIAPSIYGYEEIKEAIALQLFGGV 302
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 82 QKYADDKNRIpiRGDPHVLIVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTSSGLTVTLSKDS-SSGDFALEAGALVLGD 160
Cdd:COG1241 303 PKVLPDGSRI--RGDIHILLVGDPGTAKSQLLRYAARLAPRGVYTSGKGSTAAGLTAAAVRDDfGTGRWTLEAGALVLAD 380
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 161 QGICGIDEFDKMGNQHQ-ALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKARTVSENLKMGSALLSRFDLV 239
Cdd:COG1241 381 GGLACIDELDKMREEDRsALHEAMEQQTISIAKAGIVATLNARCSVLAAANPKYGRFDPYEPIAEQIDLPPTLLSRFDLI 460
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 240 FILLDTPNEQHDHLLSEHviairagkqkavssatvtrvlsqdsntsVLEVVSEKPLSERLKVAPGEQTDP-IPHQLLRKY 318
Cdd:COG1241 461 FVLRDKPDEERDRELARH----------------------------ILKVHRAGELLEQEIEEETEEVKPeIDPDLLRKY 512
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 319 IGYARQYVHPRLSTDAAQALQDFYLELRKQSQRVGSS-PITTRQLESLIRLTEARARLELREEATREDAEDIIEIMKHSM 397
Cdd:COG1241 513 IAYARRNVFPVLTEEAKDLIEDFYVDMRKKGEDEDSPvPITARQLEALIRLAEASARMRLSDTVTEEDAERAIRLVDSCL 592
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 398 LGTYSD-ELGNLDFERSQHGSGMSNRSTAKRFISALNSIAERtYNNIFQYHQLRQIAKELNIQVADFENFIGSLNDQGYL 476
Cdd:COG1241 593 KDVGVDpETGKFDIDVIETGTSKSQRDKMKLIKDIIKELEEE-SSGGAPIEDVIEEAEEEGIDREKAEELIEKLKRKGEI 671
|
490
....*....|
gi 12845756 477 LKKGPKIYQL 486
Cdd:COG1241 672 YEPKPGHYKK 681
|
|
| MCM |
smart00350 |
minichromosome maintenance proteins; |
2-398 |
1.44e-125 |
|
minichromosome maintenance proteins;
Pssm-ID: 214631 [Multi-domain] Cd Length: 509 Bit Score: 375.45 E-value: 1.44e-125
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 2 FLLYIEANSVsnsKGPKAQTAEDGCkHGTLMEFSLKDLYAIREIQAEENLLKLVVNSLCPVIFGHELVKAGLTLALFGGS 81
Cdd:smart00350 148 FATYIEANHV---RKLDYKRSFEDS-SFSVQSLSDEEEEEIRKLSKDPDIYERLARSLAPSIYGHEDIKKAILLLLFGGV 223
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 82 QKYADDKNRIpiRGDPHVLIVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTSSGLTVTLSKDSSSGDFALEAGALVLGDQ 161
Cdd:smart00350 224 HKNLPDGMKI--RGDINILLCGDPGTAKSQLLKYVEKTAPRAVYTTGKGSSAVGLTAAVTRDPETREFTLEAGALVLADN 301
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 162 GICGIDEFDKMGNQHQ-ALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKARTVSENLKMGSALLSRFDLVF 240
Cdd:smart00350 302 GVCCIDEFDKMDDSDRtAIHEAMEQQTISIAKAGITTTLNARCSVLAAANPIGGRYDPKLTPEENIDLPAPILSRFDLLF 381
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 241 ILLDTPNEQHDHLLSEHVIAIragkqkavssatvtRVLSQDSNTSVLEVvsekplserlkvapgeqtdPIPHQLLRKYIG 320
Cdd:smart00350 382 VVLDEVDEERDRELAKHVVDL--------------HRYSHPEEDEAFEP-------------------PLSQEKLRKYIA 428
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 321 YARQYVHPRLSTDAAQALQDFYLELRK---QSQRVGSSPITTRQLESLIRLTEARARLELREEATREDAEDIIEIMKHSM 397
Cdd:smart00350 429 YAREKIKPKLSEEAADKLVKAYVDLRKedsQTESRSSIPITVRQLESIIRLSEAHAKMRLSDVVEEADVEEAIRLLRESI 508
|
.
gi 12845756 398 L 398
Cdd:smart00350 509 I 509
|
|
| MCM |
pfam00493 |
MCM P-loop domain; |
38-262 |
1.56e-117 |
|
MCM P-loop domain;
Pssm-ID: 459830 [Multi-domain] Cd Length: 224 Bit Score: 344.13 E-value: 1.56e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 38 DLYAIREIQAEENLLKLVVNSLCPVIFGHELVKAGLTLALFGGSQKYADDKNRIpiRGDPHVLIVGDPGLGKSQMLQAAC 117
Cdd:pfam00493 1 DEEEIKELAKRPDIYDKLADSIAPSIYGHEDVKKAILLQLFGGVKKILPDGTRL--RGDINVLLVGDPGTAKSQLLKYVE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 118 NVAPRGVYVCGNTTTSSGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQ-HQALLEAMEQQSISLAKAGVV 196
Cdd:pfam00493 79 KIAPRAVYTSGKGSSAAGLTAAVVRDPVTGEFVLEAGALVLADGGVCCIDEFDKMNDEdRVALHEAMEQQTISIAKAGIV 158
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 12845756 197 CSLPARTSIIAAANPVGGHYNKARTVSENLKMGSALLSRFDLVFILLDTPNEQHDHLLSEHVIAIR 262
Cdd:pfam00493 159 ATLNARCSILAAANPIFGRYDPKKSIAENINLPPPLLSRFDLIFVLLDKPDEEKDERLAKHIVDLH 224
|
|
| PTZ00111 |
PTZ00111 |
DNA replication licensing factor MCM4; Provisional |
19-416 |
6.31e-71 |
|
DNA replication licensing factor MCM4; Provisional
Pssm-ID: 173403 [Multi-domain] Cd Length: 915 Bit Score: 242.21 E-value: 6.31e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 19 AQTAEDGCKH-GTLMEFSLKDLYAIREIQAEENLLKLVVNSLCPVIFGHELVKAGLTLALFGGSqKYADDKNRIP----- 92
Cdd:PTZ00111 407 ANQPEKGLKYlGNENDFSDLQVYKILELSRNPMIYRILLDSFAPSIKARNNVKIGLLCQLFSGN-KNSSDFNKSPdacyk 485
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 93 ---IRGDPHVLIVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTSSGLTVTLS-KDSSSGDFALEAGALVLGDQGICGIDE 168
Cdd:PTZ00111 486 vdnFRGIINVLLCGDPGTAKSQLLHYTHLLSPRSIYTSGKSSSSVGLTASIKfNESDNGRAMIQPGAVVLANGGVCCIDE 565
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 169 FDKMGNQHQALL-EAMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKARTVSENLKMGSALLSRFDLVFILLDTPN 247
Cdd:PTZ00111 566 LDKCHNESRLSLyEVMEQQTVTIAKAGIVATLKAETAILASCNPINSRYNKNKAVIENINISPSLFTRFDLIYLVLDHID 645
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 248 EQHDHLLSEhVIA--IRAGKQKAVSSATVTrvlSQDSNTSVLEvvsekplSERLKvaPGEQTDPIPHQLLRKYIGYARQY 325
Cdd:PTZ00111 646 QDTDQLISL-SIAkdFLLPHMTGSGNDEDT---YDRSNTMHVE-------DESLR--SEKDYNKNDLDMLRMYIKFSKLH 712
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 326 VHPRLSTDAAQALQDFYLELRKQS----------------------QRVGSSPIT--TRQLESLIRLTEARARLELREEA 381
Cdd:PTZ00111 713 CFPKLSDEAKKVITREYVKMRQGNfqtsnldelehaqedddddlyyQSSGTRMIYvsSRMISSIIRISVSLARMRLSTVV 792
|
410 420 430
....*....|....*....|....*....|....*.
gi 12845756 382 TREDAEDIIEIMKHSMLGTYSDEL-GNLDFERSQHG 416
Cdd:PTZ00111 793 TPADALQAVQIVKSSTFQSLVDPTtGKIDFDQLHQG 828
|
|
| MCM8_WHD |
cd22247 |
winged-helix domain (WHD) found in minichromosome maintenance 8 (MCM8) and similar proteins; ... |
422-487 |
1.63e-30 |
|
winged-helix domain (WHD) found in minichromosome maintenance 8 (MCM8) and similar proteins; MCM8 is a DNA helicase that is a component of the MCM8-MCM9 complex, which is involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR). The MCM8-MCM9 complex is also required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting its nuclease activity. This model corresponds to the C-terminal winged-helix domain (WHD) of MCM8, which mediates protein-nucleic acid interaction, as well as protein-protein interaction.
Pssm-ID: 439328 [Multi-domain] Cd Length: 66 Bit Score: 112.58 E-value: 1.63e-30
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 12845756 422 RSTAKRFISALNSIAERTYNNIFQYHQLRQIAKELNIQVADFENFIGSLNDQGYLLKKGPKIYQLQ 487
Cdd:cd22247 1 RKQAKRFVSALQREAERKGNNLFTVDELKQIAKELGLQVDDFDDFIESLNNQGYLLKKGPNLYQLQ 66
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| MCM8 |
cd17759 |
DNA helicase Mcm8; Mcm8 plays an important role homologous recombination repair. It forms a ... |
54-396 |
0e+00 |
|
DNA helicase Mcm8; Mcm8 plays an important role homologous recombination repair. It forms a complex with Mcm9 that is required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).
Pssm-ID: 350665 [Multi-domain] Cd Length: 289 Bit Score: 533.26 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 54 LVVNSLCPVIFGHELVKAGLTLALFGGSQKYADDKNRIPIRGDPHVLIVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTS 133
Cdd:cd17759 1 LIVNSLCPAIYGHELVKAGLLLSLFGGKQKYADDKNRIPIRGDPHVLIVGDPGLGKSQMLQAACNIAPRGVYVCGNTTTT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 134 SGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQHQALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVG 213
Cdd:cd17759 81 SGLTVTLTKDGRSGDFALEAGALVLGDQGICGIDEFDKMGSQHQALLEAMEQQSVSLAKAGVVCSLPARTSVIAAANPVG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 214 GHYNKARTVSENLKMGSALLSRFDLVFILLDTPNEQHDHLLSEHviairagkqkavssatvtrvlsqdsntsvlevvsek 293
Cdd:cd17759 161 GHYNKGKTVSENLKMGPALLSRFDLVFILLDTPSEEHDHLLSEH------------------------------------ 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 294 plserlkvapgeqtdpipHQLLRKYIGYARQYVHPRLSTDAAQALQDFYLELRKQSQRVGSSPITTRQLESLIRLTEARA 373
Cdd:cd17759 205 ------------------HQLLRKYISYARQYVNPVLSKDASEALQEFYLELRKQNQLADSSPITTRQLESLIRLTEARA 266
|
330 340
....*....|....*....|...
gi 12845756 374 RLELREEATREDAEDIIEIMKHS 396
Cdd:cd17759 267 RLELREEATKEDAEDVIEIMKES 289
|
|
| MCM |
cd17706 |
MCM helicase family; MCM helicases are a family of helicases that play an important role in ... |
54-396 |
4.58e-161 |
|
MCM helicase family; MCM helicases are a family of helicases that play an important role in replication and homologous recombination repair. The heterohexameric ring-shaped Mcm2-7 complex is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases. Mcm8 and Mcm9, form a complex required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).
Pssm-ID: 350658 [Multi-domain] Cd Length: 311 Bit Score: 458.35 E-value: 4.58e-161
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 54 LVVNSLCPVIFGHELVKAGLTLALFGGSQKYADDknRIPIRGDPHVLIVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTS 133
Cdd:cd17706 1 ILADSIAPSIYGHEDVKKAVLLQLFGGVQKILED--GTRIRGDIHILLVGDPGTAKSQILKYVLKIAPRGVYTSGKGSSG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 134 SGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQHQ-ALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPV 212
Cdd:cd17706 79 AGLTAAVVRDSETGEWYLEAGALVLADGGVCCIDEFDKMKELDRtALHEAMEQQTISIAKAGIVTTLNARCSILAAANPK 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 213 GGHYNKARTVSENLKMGSALLSRFDLVFILLDTPNEQHDHLLSEHVIAIRAGKQKAVssatvtrvlsqdsntsvlevvse 292
Cdd:cd17706 159 GGRYNPKLSPIENINLPSPLLSRFDLIFVIRDDPDEERDEELAEHIIDLHRGSDPEE----------------------- 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 293 kplserlKVAPGEQTDPIPHQLLRKYIGYARQyVHPRLSTDAAQALQDFYLELRKQSQRVGSSPITTRQLESLIRLTEAR 372
Cdd:cd17706 216 -------QVKPEEDGIPIDIELLRKYILYARQ-IHPKISEEAREKLVRWYVELRKESERRSTIPITARQLESVIRLAEAH 287
|
330 340
....*....|....*....|....
gi 12845756 373 ARLELREEATREDAEDIIEIMKHS 396
Cdd:cd17706 288 AKMRLSEVVTEEDVEEAIRLVRHS 311
|
|
| Mcm2 |
COG1241 |
DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and ... |
2-486 |
3.09e-146 |
|
DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair];
Pssm-ID: 440854 [Multi-domain] Cd Length: 682 Bit Score: 434.23 E-value: 3.09e-146
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 2 FLLYIEANSVSnskgPKAQTAEDgckhgtlMEFSLKDLYAIREIQAEENLLKLVVNSLCPVIFGHELVKAGLTLALFGGS 81
Cdd:COG1241 234 FDLYLEANSIE----VEEKEFEE-------IEITEEDEEKIKELSKDPDIYEKIIASIAPSIYGYEEIKEAIALQLFGGV 302
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 82 QKYADDKNRIpiRGDPHVLIVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTSSGLTVTLSKDS-SSGDFALEAGALVLGD 160
Cdd:COG1241 303 PKVLPDGSRI--RGDIHILLVGDPGTAKSQLLRYAARLAPRGVYTSGKGSTAAGLTAAAVRDDfGTGRWTLEAGALVLAD 380
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 161 QGICGIDEFDKMGNQHQ-ALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKARTVSENLKMGSALLSRFDLV 239
Cdd:COG1241 381 GGLACIDELDKMREEDRsALHEAMEQQTISIAKAGIVATLNARCSVLAAANPKYGRFDPYEPIAEQIDLPPTLLSRFDLI 460
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 240 FILLDTPNEQHDHLLSEHviairagkqkavssatvtrvlsqdsntsVLEVVSEKPLSERLKVAPGEQTDP-IPHQLLRKY 318
Cdd:COG1241 461 FVLRDKPDEERDRELARH----------------------------ILKVHRAGELLEQEIEEETEEVKPeIDPDLLRKY 512
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 319 IGYARQYVHPRLSTDAAQALQDFYLELRKQSQRVGSS-PITTRQLESLIRLTEARARLELREEATREDAEDIIEIMKHSM 397
Cdd:COG1241 513 IAYARRNVFPVLTEEAKDLIEDFYVDMRKKGEDEDSPvPITARQLEALIRLAEASARMRLSDTVTEEDAERAIRLVDSCL 592
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 398 LGTYSD-ELGNLDFERSQHGSGMSNRSTAKRFISALNSIAERtYNNIFQYHQLRQIAKELNIQVADFENFIGSLNDQGYL 476
Cdd:COG1241 593 KDVGVDpETGKFDIDVIETGTSKSQRDKMKLIKDIIKELEEE-SSGGAPIEDVIEEAEEEGIDREKAEELIEKLKRKGEI 671
|
490
....*....|
gi 12845756 477 LKKGPKIYQL 486
Cdd:COG1241 672 YEPKPGHYKK 681
|
|
| MCM |
smart00350 |
minichromosome maintenance proteins; |
2-398 |
1.44e-125 |
|
minichromosome maintenance proteins;
Pssm-ID: 214631 [Multi-domain] Cd Length: 509 Bit Score: 375.45 E-value: 1.44e-125
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 2 FLLYIEANSVsnsKGPKAQTAEDGCkHGTLMEFSLKDLYAIREIQAEENLLKLVVNSLCPVIFGHELVKAGLTLALFGGS 81
Cdd:smart00350 148 FATYIEANHV---RKLDYKRSFEDS-SFSVQSLSDEEEEEIRKLSKDPDIYERLARSLAPSIYGHEDIKKAILLLLFGGV 223
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 82 QKYADDKNRIpiRGDPHVLIVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTSSGLTVTLSKDSSSGDFALEAGALVLGDQ 161
Cdd:smart00350 224 HKNLPDGMKI--RGDINILLCGDPGTAKSQLLKYVEKTAPRAVYTTGKGSSAVGLTAAVTRDPETREFTLEAGALVLADN 301
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 162 GICGIDEFDKMGNQHQ-ALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKARTVSENLKMGSALLSRFDLVF 240
Cdd:smart00350 302 GVCCIDEFDKMDDSDRtAIHEAMEQQTISIAKAGITTTLNARCSVLAAANPIGGRYDPKLTPEENIDLPAPILSRFDLLF 381
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 241 ILLDTPNEQHDHLLSEHVIAIragkqkavssatvtRVLSQDSNTSVLEVvsekplserlkvapgeqtdPIPHQLLRKYIG 320
Cdd:smart00350 382 VVLDEVDEERDRELAKHVVDL--------------HRYSHPEEDEAFEP-------------------PLSQEKLRKYIA 428
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 321 YARQYVHPRLSTDAAQALQDFYLELRK---QSQRVGSSPITTRQLESLIRLTEARARLELREEATREDAEDIIEIMKHSM 397
Cdd:smart00350 429 YAREKIKPKLSEEAADKLVKAYVDLRKedsQTESRSSIPITVRQLESIIRLSEAHAKMRLSDVVEEADVEEAIRLLRESI 508
|
.
gi 12845756 398 L 398
Cdd:smart00350 509 I 509
|
|
| MCM_arch |
cd17761 |
archaeal MCM protein; archaeal MCM proteins form a homohexameric ring homologous to the ... |
54-393 |
3.66e-118 |
|
archaeal MCM protein; archaeal MCM proteins form a homohexameric ring homologous to the eukaryotic Mcm2-7 helicase and also function as the replicative helicase at the replication fork
Pssm-ID: 350667 [Multi-domain] Cd Length: 308 Bit Score: 349.06 E-value: 3.66e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 54 LVVNSLCPVIFGHELVKAGLTLALFGGSQKYADDKNRIpiRGDPHVLIVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTS 133
Cdd:cd17761 2 KIISSIAPSIYGHEDVKEAIALQLFGGVPKVLPDGTRI--RGDIHILLVGDPGTAKSQLLKYVSKVAPRAVYTTGKGSTA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 134 SGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQHQ-ALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPV 212
Cdd:cd17761 80 AGLTAAVVRDEGTGEWYLEAGALVLADKGIAVVDEIDKMRKEDRsALHEAMEQQTISIAKAGIVATLNARAAVLAAANPK 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 213 GGHYNKARTVSENLKMGSALLSRFDLVFILLDTPNEQHDHLLSEHVIAIRAGKQkavssatvtrvlsqdsntsvlevvse 292
Cdd:cd17761 160 FGRFDSYRPVAEQIDLPPTLLSRFDLIFVLKDTPNEEKDRRLANHILDTHSGGE-------------------------- 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 293 kplserlkvaPGEQTDPIPHQLLRKYIGYARQYVHPRLSTDAAQALQDFYLELRKQSQRVGSS-PITTRQLESLIRLTEA 371
Cdd:cd17761 214 ----------MREIKPEIDPDLLRKYIAYARKNVRPVLTEEAKQLIKDFYVEMRKSGQETPSPvPITARQLEALVRLSEA 283
|
330 340
....*....|....*....|..
gi 12845756 372 RARLELREEATREDAEDIIEIM 393
Cdd:cd17761 284 SARMRLSQEVTLEDAERAIRIM 305
|
|
| MCM |
pfam00493 |
MCM P-loop domain; |
38-262 |
1.56e-117 |
|
MCM P-loop domain;
Pssm-ID: 459830 [Multi-domain] Cd Length: 224 Bit Score: 344.13 E-value: 1.56e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 38 DLYAIREIQAEENLLKLVVNSLCPVIFGHELVKAGLTLALFGGSQKYADDKNRIpiRGDPHVLIVGDPGLGKSQMLQAAC 117
Cdd:pfam00493 1 DEEEIKELAKRPDIYDKLADSIAPSIYGHEDVKKAILLQLFGGVKKILPDGTRL--RGDINVLLVGDPGTAKSQLLKYVE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 118 NVAPRGVYVCGNTTTSSGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQ-HQALLEAMEQQSISLAKAGVV 196
Cdd:pfam00493 79 KIAPRAVYTSGKGSSAAGLTAAVVRDPVTGEFVLEAGALVLADGGVCCIDEFDKMNDEdRVALHEAMEQQTISIAKAGIV 158
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 12845756 197 CSLPARTSIIAAANPVGGHYNKARTVSENLKMGSALLSRFDLVFILLDTPNEQHDHLLSEHVIAIR 262
Cdd:pfam00493 159 ATLNARCSILAAANPIFGRYDPKKSIAENINLPPPLLSRFDLIFVLLDKPDEEKDERLAKHIVDLH 224
|
|
| MCM2 |
cd17753 |
DNA replication licensing factor Mcm2; Mcm2 is a helicase that play an important role in ... |
55-396 |
1.73e-110 |
|
DNA replication licensing factor Mcm2; Mcm2 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.
Pssm-ID: 350659 [Multi-domain] Cd Length: 325 Bit Score: 330.18 E-value: 1.73e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 55 VVNSLCPVIFGHELVKAGLTLALFGGSQKYADDKNRIpiRGDPHVLIVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTSS 134
Cdd:cd17753 2 IINSIAPSIYGHDDIKTAIALALFGGVAKNPGGKHRI--RGDINVLLLGDPGTAKSQFLKYVEKTAHRAVFTTGQGASAV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 135 GLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQHQ-ALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVG 213
Cdd:cd17753 80 GLTASVRKDPVTKEWTLEGGALVLADKGVCLIDEFDKMNDQDRtSIHEAMEQQSISISKAGIVTSLQARCSVIAAANPIG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 214 GHYNKARTVSENLKMGSALLSRFDLVFILLDTPNEQHDHLLSEHVIAIRAGKQKavssatvtrvlSQDSNTSVLEVVSEK 293
Cdd:cd17753 160 GRYNPTLTFAQNVNLTEPILSRFDILCVVRDTVDPEEDERLAKFVVGSHVRSHP-----------ENDEDREGEEEKNQR 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 294 PLSERLKVapgeqtDPIPHQLLRKYIGYARQYVHPRLSTDAAQALQDFYLELRKQSQRVGSSPITTRQLESLIRLTEARA 373
Cdd:cd17753 229 QRPKETKV------EPIPQELLRKYIHYAREKVRPKLNQMDMDKVSRVYADLRKESMATGSLPITVRHLESIIRISEAHA 302
|
330 340
....*....|....*....|...
gi 12845756 374 RLELREEATREDAEDIIEIMKHS 396
Cdd:cd17753 303 KMHLREYVSEEDVDMAIRVMLDS 325
|
|
| MCM6 |
cd17757 |
DNA replication licensing factor Mcm6; Mcm6 is a helicase that play an important role in ... |
56-396 |
3.75e-105 |
|
DNA replication licensing factor Mcm6; Mcm6 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.
Pssm-ID: 350663 [Multi-domain] Cd Length: 307 Bit Score: 315.85 E-value: 3.75e-105
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 56 VNSLCPVIFGHELVKAGLTLALFGGSQKYADDKnrIPIRGDPHVLIVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTSSG 135
Cdd:cd17757 3 VRSIAPSIYGHEEVKKGILLMLLGGVHKITREG--ISLRGDINVCIVGDPSTAKSQFLKYVEEFSPRAVYTSGKASSAAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 136 LTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQHQ-ALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVGG 214
Cdd:cd17757 81 LTAAVVRDEETGDFVIEAGALMLADNGICCIDEFDKMDIKDQvAIHEAMEQQTISITKAGIQATLNARTSILAAANPVGG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 215 HYNKARTVSENLKMGSALLSRFDLVFILLDTPNEQHDHLLSEHVIAIRAGKQKAVSSatvtrvlsqdsntsvlevvsekp 294
Cdd:cd17757 161 RYDRSKSLKQNINISAPIMSRFDLFFVLLDECNEVTDYAIASHIVDLHSKREEAIEP----------------------- 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 295 lserlkvapgeqtdPIPHQLLRKYIGYARQyVHPRLSTDAAQALQDFYLELRKQSQRVGSSP---ITTRQLESLIRLTEA 371
Cdd:cd17757 218 --------------PFTAEQLKRYIAYART-FKPKLTKEAKDELVEQYKELRQDDASGSTRSsyrITVRQLESLIRLSEA 282
|
330 340
....*....|....*....|....*
gi 12845756 372 RARLELREEATREDAEDIIEIMKHS 396
Cdd:cd17757 283 IARLHCSDEVTPEHVEEAARLLKKS 307
|
|
| MCM4 |
cd17755 |
DNA replication licensing factor Mcm4; Mcm4 is a helicase that play an important role in ... |
54-394 |
2.42e-103 |
|
DNA replication licensing factor Mcm4; Mcm4 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.
Pssm-ID: 350661 [Multi-domain] Cd Length: 309 Bit Score: 311.29 E-value: 2.42e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 54 LVVNSLCPVIFGHELVKAGLTLALFGGSQKyADDKNRIPIRGDPHVLIVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTS 133
Cdd:cd17755 1 RLARSIAPSIYELEDVKKGILLQLFGGTRK-DFTKTGGKYRGDINILLCGDPGTSKSQLLQYVHKISPRGVYTSGKGSSA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 134 SGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQHQALL-EAMEQQSISLAKAGVVCSLPARTSIIAAANPV 212
Cdd:cd17755 80 VGLTAYVTRDPDTKQLVLESGALVLSDGGICCIDEFDKMSDSTRSVLhEVMEQQTLSIAKAGIITTLNARTSILASANPI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 213 GGHYNKARTVSENLKMGSALLSRFDLVFILLDTPNEQHDHLLSEHVIAIragkqkavssatvtrvlsqdsntsvleVVSE 292
Cdd:cd17755 160 GSRYNPKLTVVENIDLPPTLLSRFDLIYLVLDKVDEKYDRRLAKHLVSL---------------------------YLED 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 293 KPLSerlkvapgEQTDPIPHQLLRKYIGYARQYVHPRLSTDAAQALQDFYLELRK-QSQRVGSSPITTRQLESLIRLTEA 371
Cdd:cd17755 213 TPEH--------IQDEVLDVEVLTDYISYAREHIHPKLSEEAAQELVQAYVDMRKmGSDARKRITATPRQLESLIRLAEA 284
|
330 340
....*....|....*....|...
gi 12845756 372 RARLELREEATREDAEDIIEIMK 394
Cdd:cd17755 285 HAKMRLSNVVEAEDVEEAVRLIR 307
|
|
| MCM5 |
cd17756 |
DNA replication licensing factor Mcm5; Mcm5 is a helicase that play an important role in ... |
54-396 |
1.59e-102 |
|
DNA replication licensing factor Mcm5; Mcm5 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.
Pssm-ID: 350662 [Multi-domain] Cd Length: 317 Bit Score: 309.70 E-value: 1.59e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 54 LVVNSLCPVIFGHELVKAGLTLALFGGSQKYADDKNRIpiRGDPHVLIVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTS 133
Cdd:cd17756 1 IISKSIAPSIYGNEDIKKAIACLLFGGSRKRLPDGMRL--RGDINVLLLGDPGTAKSQLLKFVEKVAPIGVYTSGKGSSA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 134 SGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQHQ-ALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPV 212
Cdd:cd17756 79 AGLTASVMRDPSTREFYLEGGAMVLADGGVVCIDEFDKMREDDRvAIHEAMEQQTISIAKAGITTTLNSRTSVLAAANPV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 213 GGHYNKARTVSENLKMGSALLSRFDLVFILLDTPNEQHDHLLSEHVIAIRAGKQKAVSSatvtrvlsqdsntsvlevvse 292
Cdd:cd17756 159 FGRYDDLKTPGDNIDFQTTILSRFDMIFIVKDKHDEERDITIAKHVINIHASARKASQS--------------------- 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 293 kplserlkvapGEQTDPIPHQLLRKYIGYARQYVHPRLSTDAAQALQDFYLELRKQ-------SQRVGSSPITTRQLESL 365
Cdd:cd17756 218 -----------QENEGEIPISKLKRYIAYCRAKCAPRLSEEAAEKLSNHYVTIRKDvrqneleSDNRSSIPITVRQLEAI 286
|
330 340 350
....*....|....*....|....*....|.
gi 12845756 366 IRLTEARARLELREEATREDAEDIIEIMKHS 396
Cdd:cd17756 287 IRISESLAKMELSPIATEKHVEEAIRLFQVS 317
|
|
| MCM7 |
cd17758 |
DNA replication licensing factor Mcm7; Mcm7 is a helicase that play an important role in ... |
58-396 |
9.31e-95 |
|
DNA replication licensing factor Mcm7; Mcm7 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.
Pssm-ID: 350664 [Multi-domain] Cd Length: 306 Bit Score: 289.31 E-value: 9.31e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 58 SLCPVIFGHELVKAGLTLALFGGSQKYADDknrIPIRGDPHVLIVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTSSGLT 137
Cdd:cd17758 5 SIAPEIYGHEDVKKALLLLLVGGVDKRGDG---MKIRGDINICLMGDPGVAKSQLLKYICRIAPRSVYTTGRGSSGVGLT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 138 VTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQHQ-ALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHY 216
Cdd:cd17758 82 AAVMKDPVTGEMTLEGGALVLADQGICCIDEFDKMDESDRtAIHEVMEQQTISIAKAGITTTLNARTSILAAANPAYGRY 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 217 NKARTVSENLKMGSALLSRFDLVFILLDTPNEQHDHLLSEHviairagkqkavssatVTRVLSQDsntsvlevvsekpls 296
Cdd:cd17758 162 NPRRSPEQNINLPAALLSRFDLLFLILDKPDRDNDLRLAEH----------------VTYVHQHN--------------- 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 297 erlkVAPGEQTDPIPHQLLRKYIGYARQYvHPRLSTDAAQALQDFYLELRKQSQRVGSSPITT-RQLESLIRLTEARARL 375
Cdd:cd17758 211 ----KQPDSDFEPLDPKLLRAYIALAKRK-RPTVPPALADYIVQAYVEMRQEAKRSKDFTFTTpRTLLAILRLSQALARL 285
|
330 340
....*....|....*....|.
gi 12845756 376 ELREEATREDAEDIIEIMKHS 396
Cdd:cd17758 286 RLSDSVEIDDVEEALRLMEMS 306
|
|
| MCM9 |
cd17760 |
DNA helicase Mcm9; Mcm9 plays an important role homologous recombination repair. It forms a ... |
54-396 |
3.57e-89 |
|
DNA helicase Mcm9; Mcm9 plays an important role homologous recombination repair. It forms a complex with Mcm8 that is required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).
Pssm-ID: 350666 [Multi-domain] Cd Length: 299 Bit Score: 274.81 E-value: 3.57e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 54 LVVNSLCPVIFGHELVKAGLTLALFGGSQKYADDKNRIpiRGDPHVLIVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTS 133
Cdd:cd17760 1 EILASLCPQVFGLYNVKLAVAMVLAGGVQRIDASGTRV--RGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTAGIGSTS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 134 SGLTVTLSKDssSGDFALEAGALVLGDQGICGIDEFDKMG-NQHQALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPv 212
Cdd:cd17760 79 AGLTVTAVKD--GGEWNLEAGALVLADGGLCCIDEFNSLKeHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNP- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 213 GGHYNKARTVSENLKMGSALLSRFDLVFILLDTPNEQHDHLLSEhviairagkqkavssatvtRVLSQDSNTSVLEVVse 292
Cdd:cd17760 156 KGQYDPNESISVNIALASPLLSRFDLVLVLLDTKNEDWDRIISS-------------------FILENKGEPSKSSKL-- 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 293 kplserlkvapgeqtdpIPHQLLRKYIGYARQyVHPRLSTDAAQALQDFYlELRKQSQRVGSSPITTRQLESLIRLTEAR 372
Cdd:cd17760 215 -----------------WSMEKMRTYFCLIKN-LRPVLSDEANAILLRYY-QLQRQSDCRNAARTTIRMLESLIRLAEAH 275
|
330 340
....*....|....*....|....
gi 12845756 373 ARLELREEATREDAEDIIEIMKHS 396
Cdd:cd17760 276 ARLMFRETVTEEDAITVVSVMESS 299
|
|
| MCM3 |
cd17754 |
DNA replication licensing factor Mcm3; Mcm3 is a helicase that play an important role in ... |
54-394 |
5.58e-81 |
|
DNA replication licensing factor Mcm3; Mcm3 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.
Pssm-ID: 350660 [Multi-domain] Cd Length: 299 Bit Score: 253.54 E-value: 5.58e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 54 LVVNSLCPVIFGHELVKAGLTLALFGGSQKyaDDKNRIPIRGDPHVLIVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTS 133
Cdd:cd17754 1 LLSKSLAPSIYGHEYIKKAILLMLLGGVEK--NLENGSHLRGDINILLVGDPSVAKSQLLRYVLNTAPLAIATTGRGSSG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 134 SGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQHQ-ALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPV 212
Cdd:cd17754 79 VGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDIDRvAIHEVMEQQTVTIAKAGIHASLNARCSVLAAANPV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 213 GGHYNKARTVSENLKMGSALLSRFDLVFILLDTPNEQHDHLLSEHVIAIRagkqkavssatvtRVLsqdsntsvlevvse 292
Cdd:cd17754 159 YGRYDVYKTPMENIGLPDSLLSRFDLLFIVLDDIDEERDRSISEHVLRMH-------------RYI-------------- 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 293 kplserlkvapgeqtdpiphQLLRKYIGYARQYVHPRLSTDAAQALQDFYLELRKQ----SQRVGSSPITTRQLESLIRL 368
Cdd:cd17754 212 --------------------KFLRKYIHYAKERIKPKLTQEAAEYIAEEYADLRNDdntkTDKARTSPITARTLETLIRL 271
|
330 340
....*....|....*....|....*.
gi 12845756 369 TEARARLELREEATREDAEDIIEIMK 394
Cdd:cd17754 272 ATAHAKARLSKTVDKVDAEVALNLLR 297
|
|
| PTZ00111 |
PTZ00111 |
DNA replication licensing factor MCM4; Provisional |
19-416 |
6.31e-71 |
|
DNA replication licensing factor MCM4; Provisional
Pssm-ID: 173403 [Multi-domain] Cd Length: 915 Bit Score: 242.21 E-value: 6.31e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 19 AQTAEDGCKH-GTLMEFSLKDLYAIREIQAEENLLKLVVNSLCPVIFGHELVKAGLTLALFGGSqKYADDKNRIP----- 92
Cdd:PTZ00111 407 ANQPEKGLKYlGNENDFSDLQVYKILELSRNPMIYRILLDSFAPSIKARNNVKIGLLCQLFSGN-KNSSDFNKSPdacyk 485
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 93 ---IRGDPHVLIVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTSSGLTVTLS-KDSSSGDFALEAGALVLGDQGICGIDE 168
Cdd:PTZ00111 486 vdnFRGIINVLLCGDPGTAKSQLLHYTHLLSPRSIYTSGKSSSSVGLTASIKfNESDNGRAMIQPGAVVLANGGVCCIDE 565
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 169 FDKMGNQHQALL-EAMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKARTVSENLKMGSALLSRFDLVFILLDTPN 247
Cdd:PTZ00111 566 LDKCHNESRLSLyEVMEQQTVTIAKAGIVATLKAETAILASCNPINSRYNKNKAVIENINISPSLFTRFDLIYLVLDHID 645
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 248 EQHDHLLSEhVIA--IRAGKQKAVSSATVTrvlSQDSNTSVLEvvsekplSERLKvaPGEQTDPIPHQLLRKYIGYARQY 325
Cdd:PTZ00111 646 QDTDQLISL-SIAkdFLLPHMTGSGNDEDT---YDRSNTMHVE-------DESLR--SEKDYNKNDLDMLRMYIKFSKLH 712
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 326 VHPRLSTDAAQALQDFYLELRKQS----------------------QRVGSSPIT--TRQLESLIRLTEARARLELREEA 381
Cdd:PTZ00111 713 CFPKLSDEAKKVITREYVKMRQGNfqtsnldelehaqedddddlyyQSSGTRMIYvsSRMISSIIRISVSLARMRLSTVV 792
|
410 420 430
....*....|....*....|....*....|....*.
gi 12845756 382 TREDAEDIIEIMKHSMLGTYSDEL-GNLDFERSQHG 416
Cdd:PTZ00111 793 TPADALQAVQIVKSSTFQSLVDPTtGKIDFDQLHQG 828
|
|
| MCM_lid |
pfam17855 |
MCM AAA-lid domain; This entry represents the AAA-lid domain found in MCM proteins. |
313-397 |
5.79e-36 |
|
MCM AAA-lid domain; This entry represents the AAA-lid domain found in MCM proteins.
Pssm-ID: 465534 [Multi-domain] Cd Length: 86 Bit Score: 128.04 E-value: 5.79e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 313 QLLRKYIGYARQYVHPRLSTDAAQALQDFYLELRKQSQRVGSS-PITTRQLESLIRLTEARARLELREEATREDAEDIIE 391
Cdd:pfam17855 1 ELLRKYIAYAREKIKPKLSEEAREKLVDAYVELRKESTGSGSSiPITVRQLESLIRLSEAHAKMRLSEIVTEEDVEEAIR 80
|
....*.
gi 12845756 392 IMKHSM 397
Cdd:pfam17855 81 LLKESL 86
|
|
| MCM8_WHD |
cd22247 |
winged-helix domain (WHD) found in minichromosome maintenance 8 (MCM8) and similar proteins; ... |
422-487 |
1.63e-30 |
|
winged-helix domain (WHD) found in minichromosome maintenance 8 (MCM8) and similar proteins; MCM8 is a DNA helicase that is a component of the MCM8-MCM9 complex, which is involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR). The MCM8-MCM9 complex is also required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting its nuclease activity. This model corresponds to the C-terminal winged-helix domain (WHD) of MCM8, which mediates protein-nucleic acid interaction, as well as protein-protein interaction.
Pssm-ID: 439328 [Multi-domain] Cd Length: 66 Bit Score: 112.58 E-value: 1.63e-30
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 12845756 422 RSTAKRFISALNSIAERTYNNIFQYHQLRQIAKELNIQVADFENFIGSLNDQGYLLKKGPKIYQLQ 487
Cdd:cd22247 1 RKQAKRFVSALQREAERKGNNLFTVDELKQIAKELGLQVDDFDDFIESLNNQGYLLKKGPNLYQLQ 66
|
|
| MoxR |
COG0714 |
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway ... |
98-409 |
2.76e-10 |
|
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis
Pssm-ID: 440478 [Multi-domain] Cd Length: 292 Bit Score: 61.34 E-value: 2.76e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 98 HVLIVGDPGLGKSQMLQAacnVAprgvyvcgnttTSSGL-------TVTL--SK-------DSSSGDFALEAGAL----V 157
Cdd:COG0714 33 HLLLEGVPGVGKTTLAKA---LA-----------RALGLpfiriqfTPDLlpSDilgtyiyDQQTGEFEFRPGPLfanvL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 158 LgdqgicgIDEFDKMGNQHQ-ALLEAMEQQSISLakAGVVCSLPARTSIIAAANPVGghynKART--VSEnlkmgsALLS 234
Cdd:COG0714 99 L-------ADEINRAPPKTQsALLEAMEERQVTI--PGGTYKLPEPFLVIATQNPIE----QEGTypLPE------AQLD 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 235 RFdLVFILLDTPNEqhdhllsEHVIAIRAGKQkAVSSATVTRVLSQDSNTSVLEVVSEKPLSERLKvapgeqtdpiphql 314
Cdd:COG0714 160 RF-LLKLYIGYPDA-------EEEREILRRHT-GRHLAEVEPVLSPEELLALQELVRQVHVSEAVL-------------- 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 315 lrkyiGYARQYVHprlstdaaqalqdfylELRKQSQ-RVGSSPittRQLESLIRLTEARARLELREEATREDAEDIIE-I 392
Cdd:COG0714 217 -----DYIVDLVR----------------ATREHPDlRKGPSP---RASIALLRAARALALLDGRDYVTPDDVKAVAGpV 272
|
330
....*....|....*..
gi 12845756 393 MKHSMLGTYSDELGNLD 409
Cdd:COG0714 273 LKHRLILSPEADAEGVT 289
|
|
| AAA |
cd00009 |
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ... |
84-242 |
7.15e-07 |
|
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.
Pssm-ID: 99707 [Multi-domain] Cd Length: 151 Bit Score: 48.68 E-value: 7.15e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 84 YADDKNRIPIRGDPHVLIVGDPGLGKSQMLQA-ACNVAPRGVYVCgnTTTSSGLTVTLSKDSSSGDFALEA--GALVLGD 160
Cdd:cd00009 7 IEALREALELPPPKNLLLYGPPGTGKTTLARAiANELFRPGAPFL--YLNASDLLEGLVVAELFGHFLVRLlfELAEKAK 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 161 QGICGIDEFDKMGNQ-HQALLEAMEQQSISLAKagvvcslPARTSIIAAANPvgghynkartvSENLKMGSALLSRFDLV 239
Cdd:cd00009 85 PGVLFIDEIDSLSRGaQNALLRVLETLNDLRID-------RENVRVIGATNR-----------PLLGDLDRALYDRLDIR 146
|
...
gi 12845756 240 FIL 242
Cdd:cd00009 147 IVI 149
|
|
| AAA_5 |
pfam07728 |
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ... |
98-236 |
9.94e-06 |
|
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.
Pssm-ID: 400191 [Multi-domain] Cd Length: 135 Bit Score: 44.98 E-value: 9.94e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 98 HVLIVGDPGLGKSQMLQaacnvaprgvYVCGNTTTSSGLTVTLSKDSSSGDF-----------ALEAGALVLGDQ--GIC 164
Cdd:pfam07728 1 GVLLVGPPGTGKTELAE----------RLAAALSNRPVFYVQLTRDTTEEDLfgrrnidpggaSWVDGPLVRAARegEIA 70
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 12845756 165 GIDEFDKMGNQHQ-ALLEAMEQQSISLAKAGVVCSLPA-RTSIIAAANPVGghynkaRTVSEnlkMGSALLSRF 236
Cdd:pfam07728 71 VLDEINRANPDVLnSLLSLLDERRLLLPDGGELVKAAPdGFRLIATMNPLD------RGLNE---LSPALRSRF 135
|
|
| PRK09862 |
PRK09862 |
ATP-dependent protease; |
152-279 |
1.09e-04 |
|
ATP-dependent protease;
Pssm-ID: 182120 [Multi-domain] Cd Length: 506 Bit Score: 44.59 E-value: 1.09e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845756 152 EAGALVLGDQGICGIDEFDKMGNQH-QALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPV-GGHY--NKARTVSENL- 226
Cdd:PRK09862 286 GPGEISLAHNGVLFLDELPEFERRTlDALREPIESGQIHLSRTRAKITYPARFQLVAAMNPSpTGHYqgNHNRCTPEQTl 365
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 12845756 227 ----KMGSALLSRFDLVF-ILLDTPNeqhdhLLSEHVIairagkqKAVSSATV-TRVLS 279
Cdd:PRK09862 366 rylnRLSGPFLDRFDLSLeIPLPPPG-----ILSKTVV-------PGESSATVkQRVMA 412
|
|
| RadA_SMS_N |
cd01121 |
bacterial RadA DNA repair protein; Sms or bacterial RadA is a DNA repair protein that plays a ... |
99-128 |
3.16e-04 |
|
bacterial RadA DNA repair protein; Sms or bacterial RadA is a DNA repair protein that plays a role in recombination and recombinational repair of DNA damaged by UV radiation, X-rays, and chemical agent and is responsible for the stabilization or processing of branched DNA molecules.
Pssm-ID: 410866 [Multi-domain] Cd Length: 268 Bit Score: 42.52 E-value: 3.16e-04
10 20 30
....*....|....*....|....*....|....
gi 12845756 99 VLIVGDPGLGKSQ-MLQAACNVAPRG---VYVCG 128
Cdd:cd01121 85 VLIGGDPGIGKSTlLLQVAARLAQRGgkvLYVSG 118
|
|
| Sms |
COG1066 |
DNA repair protein RadA/Sms, contains AAA+ ATPase domain [Replication, recombination and ... |
99-128 |
7.44e-04 |
|
DNA repair protein RadA/Sms, contains AAA+ ATPase domain [Replication, recombination and repair];
Pssm-ID: 440685 [Multi-domain] Cd Length: 453 Bit Score: 41.96 E-value: 7.44e-04
10 20 30
....*....|....*....|....*....|....
gi 12845756 99 VLIVGDPGLGKSQ-MLQAACNVAPRG---VYVCG 128
Cdd:COG1066 92 VLIGGEPGIGKSTlLLQVAARLAKKGgkvLYVSG 125
|
|
| COG2842 |
COG2842 |
Bacteriophage DNA transposition protein, AAA+ family ATPase [Mobilome: prophages, transposons]; ... |
99-136 |
6.68e-03 |
|
Bacteriophage DNA transposition protein, AAA+ family ATPase [Mobilome: prophages, transposons];
Pssm-ID: 442090 [Multi-domain] Cd Length: 254 Bit Score: 38.39 E-value: 6.68e-03
10 20 30
....*....|....*....|....*....|....*....
gi 12845756 99 VLIVGDPGLGKSQMLQAACNVAPRGVYV-CGNTTTSSGL 136
Cdd:COG2842 53 GVVYGESGVGKTTAAREYANRNPNVIYVtASPSWTSKEL 91
|
|
| |
