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Conserved domains on  [gi|12854173|dbj|BAB29948|]
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unnamed protein product, partial [Mus musculus]

Protein Classification

SET domain-containing protein( domain architecture ID 1562517)

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain-containing protein may function as a protein-lysine N-methyltransferase, catalyzing the S-adenosyl-L-methionine (SAM)-dependent methylation at specific lysine residues of target proteins such as histones

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SET super family cl40432
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, ...
 1-171 5.29e-128

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, Enhancer-of-zeste, Trithorax (SET) domain superfamily corresponds to SET domain-containing lysine methyltransferases, which catalyze site and state-specific methylation of lysine residues in histones that are fundamental in epigenetic regulation of gene activation and silencing in eukaryotic organisms. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains has been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as N-SET and C-SET. C-SET forms an unusual and conserved knot-like structure of probable functional importance. In addition to N-SET and C-SET, an insert region (I-SET) and flanking regions of high structural variability form part of the overall structure. Some family members contain a pre-SET domain, which is found in a number of histone methyltransferases (HMTase), and a post-SET domain, which harbors a zinc-binding site.


The actual alignment was detected with superfamily member cd10532:

Pssm-ID: 394802 [Multi-domain]  Cd Length: 243  Bit Score: 358.82  E-value: 5.29e-128
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12854173   1 CPNRIVQKGTQYSLCIFRTSNGCGWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQFYDNKGITYLFDLDYESDEFTVD 80
Cdd:cd10532  73 CPNRVVQKGTQYSLCIFRTSNGRGWGVKTLQKIKKNSFVMEYVGEVITSEEAERRGQFYDSKGITYLFDLDYESDEFTVD 152

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12854173  81 AARYGNVSHFVNHSCDPNLQVFSVFIDNLDTRLPRIALFSTRTINAGEELTFDYQMKGSGEASSDSIDHSPAKKRVRTQC 160
Cdd:cd10532 153 AARYGNVSHFVNHSCDPNLQVFNVFIDNLDTRLPRIALFSTRTIKAGEELTFDYQMKGSGDLSSDSIDNSPAKKRVRTVC 232

                       170
                ....*....|.
gi 12854173 161 KCGAETCRGYL 171
Cdd:cd10532 233 KCGAVTCRGYL 243
 
Name Accession Description Interval E-value
SET_SUV39H2 cd10532
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 1-171 5.29e-128

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 2 (SUV39H2) and similar proteins; SUV39H2 (EC 2.1.1.43; also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B (KMT1B), or Su(var)3-9 homolog 2) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. It mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions.


Pssm-ID: 380930 [Multi-domain]  Cd Length: 243  Bit Score: 358.82  E-value: 5.29e-128
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12854173   1 CPNRIVQKGTQYSLCIFRTSNGCGWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQFYDNKGITYLFDLDYESDEFTVD 80
Cdd:cd10532  73 CPNRVVQKGTQYSLCIFRTSNGRGWGVKTLQKIKKNSFVMEYVGEVITSEEAERRGQFYDSKGITYLFDLDYESDEFTVD 152

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12854173  81 AARYGNVSHFVNHSCDPNLQVFSVFIDNLDTRLPRIALFSTRTINAGEELTFDYQMKGSGEASSDSIDHSPAKKRVRTQC 160
Cdd:cd10532 153 AARYGNVSHFVNHSCDPNLQVFNVFIDNLDTRLPRIALFSTRTIKAGEELTFDYQMKGSGDLSSDSIDNSPAKKRVRTVC 232

                       170
                ....*....|.
gi 12854173 161 KCGAETCRGYL 171
Cdd:cd10532 233 KCGAVTCRGYL 243
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 12-141 1.10e-41

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 135.93  E-value: 1.10e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12854173     12 YSLCIFRtSNGCGWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQFYDNKGI--TYLFDLDyesDEFTVDAARYGNVSH 89
Cdd:smart00317   1 NKLEVFK-SPGKGWGVRATEDIPKGEFIGEYVGEIITSEEAEERPKAYDTDGAkaFYLFDID---SDLCIDARRKGNLAR 76

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 12854173     90 FVNHSCDPNLQVFSVFIDNLDtrlpRIALFSTRTINAGEELTFDYQMKGSGE 141
Cdd:smart00317  77 FINHSCEPNCELLFVEVNGDD----RIVIFALRDIKPGEELTIDYGSDYANE 124
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 24-134 1.27e-27

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 99.90  E-value: 1.27e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12854173    24 GWGVKTLVKIKRMSFVMEYVGE-VITSEEAERRGQFY-----DNKGITYLFDLDyESDEFTVD--AARYGNVSHFVNHSC 95
Cdd:pfam00856   1 GRGLFATEDIPKGEFIGEYVEVlLITKEEADKRELLYydkleLRLWGPYLFTLD-EDSEYCIDarALYYGNWARFINHSC 79

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 12854173    96 DPNLQVFSVFIDnldtRLPRIALFSTRTINAGEELTFDY 134
Cdd:pfam00856  80 DPNCEVRVVYVN----GGPRIVIFALRDIKPGEELTIDY 114
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
18-169 6.53e-27

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 98.50  E-value: 6.53e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12854173  18 RTSNGCGWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQFyDNKGITYLFDLDyesDEFTVDAARYGNVSHFVNHSCDP 97
Cdd:COG2940  11 RPSPIHGRGVFATRDIPKGTLIGEYPGEVITWAEAERREPH-KEPLHTYLFELD---DDGVIDGALGGNPARFINHSCDP 86

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 12854173  98 NLQvfsvfidnLDTRLPRIALFSTRTINAGEELTFDYqmkgsgeasSDSIDHSPAKkrvrtqCKCGaeTCRG 169
Cdd:COG2940  87 NCE--------ADEEDGRIFIVALRDIAAGEELTYDY---------GLDYDEEEYP------CRCP--NCRG 133
 
Name Accession Description Interval E-value
SET_SUV39H2 cd10532
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 1-171 5.29e-128

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 2 (SUV39H2) and similar proteins; SUV39H2 (EC 2.1.1.43; also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B (KMT1B), or Su(var)3-9 homolog 2) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. It mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions.


Pssm-ID: 380930 [Multi-domain]  Cd Length: 243  Bit Score: 358.82  E-value: 5.29e-128
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12854173   1 CPNRIVQKGTQYSLCIFRTSNGCGWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQFYDNKGITYLFDLDYESDEFTVD 80
Cdd:cd10532  73 CPNRVVQKGTQYSLCIFRTSNGRGWGVKTLQKIKKNSFVMEYVGEVITSEEAERRGQFYDSKGITYLFDLDYESDEFTVD 152

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12854173  81 AARYGNVSHFVNHSCDPNLQVFSVFIDNLDTRLPRIALFSTRTINAGEELTFDYQMKGSGEASSDSIDHSPAKKRVRTQC 160
Cdd:cd10532 153 AARYGNVSHFVNHSCDPNLQVFNVFIDNLDTRLPRIALFSTRTIKAGEELTFDYQMKGSGDLSSDSIDNSPAKKRVRTVC 232

                       170
                ....*....|.
gi 12854173 161 KCGAETCRGYL 171
Cdd:cd10532 233 KCGAVTCRGYL 243
SET_SUV39H cd10542
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 1-171 6.71e-112

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homologs, SUV39H1, SUV39H2 and similar proteins; This family includes SUV39H1 (also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A, KMT1A, position-effect variegation 3-9 homolog, SUV39H, or Su(var)3-9 homolog 1) and SUV39H2 (also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B, KMT1B, or Su(var)3-9 homolog 2), both act as histone-lysine N-methyltransferases that specifically trimethylate 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. They mainly function in heterochromatin regions, thereby playing central roles in the establishment of constitutive heterochromatin at pericentric and telomere regions. Also included are Schizosaccharomyces pombe H3K9 methyltransferase Clr4 (SUV39H homolog) and Neurospora crassa DIM-5, both of which also methylate 'Lys-9' of histone H3.


Pssm-ID: 380940 [Multi-domain]  Cd Length: 245  Bit Score: 318.08  E-value: 6.71e-112
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12854173   1 CPNRIVQKGTQYSLCIFRTSNGCGWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQFYDNKGITYLFDLDYESD--EFT 78
Cdd:cd10542  76 CPNRVVQRGRKVPLCIFRTSNGRGWGVKTLEDIKKGTFVMEYVGEIITSEEAERRGKIYDANGRTYLFDLDYNDDdcEYT 155

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12854173  79 VDAARYGNVSHFVNHSCDPNLQVFSVFIDNLDTRLPRIALFSTRTINAGEELTFDYQMKGSGeasSDSIDHSPAKKRVRT 158
Cdd:cd10542 156 VDAAYYGNISHFINHSCDPNLAVYAVWINHLDPRLPRIAFFAKRDIKAGEELTFDYLMTGTG---GSSESTIPKPKDVRV 232

                       170
                ....*....|...
gi 12854173 159 QCKCGAETCRGYL 171
Cdd:cd10542 233 PCLCGSKNCRKYL 245
SET_SUV39H1 cd10525
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 1-171 1.68e-92

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 1 (SUV39H1) and similar proteins; SUV39H1 (EC 2.1.1.43; also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A (KMT1A), position-effect variegation 3-9 homolog (SUV39H), or Su(var)3-9 homolog 1) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. It mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions.


Pssm-ID: 380923 [Multi-domain]  Cd Length: 255  Bit Score: 269.45  E-value: 1.68e-92
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12854173   1 CPNRIVQKGTQYSLCIFRTSNGCGWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQFYDNKGITYLFDLDYESDEFTVD 80
Cdd:cd10525  75 CPNRVVQKGIQYDLCIFRTDNGRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGATYLFDLDYVEDVYTVD 154

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12854173  81 AARYGNVSHFVNHSCDPNLQVFSVFIDNLDTRLPRIALFSTRTINAGEELTFDYQMK-GSGEASSDSIDH---------S 150
Cdd:cd10525 155 AAYYGNISHFVNHSCDPNLQVYNVFIDNLDERLPRIALFATRTIRAGEELTFDYNMQvDPVDAESTKMDSnfglaglpgS 234

                       170       180
                ....*....|....*....|.
gi 12854173 151 PaKKRVRTQCKCGAETCRGYL 171
Cdd:cd10525 235 P-KKRVRIECKCGVRSCRKYL 254
SET_SETDB-like cd10538
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) ...
 1-135 8.48e-72

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2, and similar proteins; The family includes SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2. SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis. SUV39H1 (also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A, KMT1A, position-effect variegation 3-9 homolog, SUV39H, or Su(var)3-9 homolog 1) and SUV39H2 (also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B, KMT1B, or Su(var)3-9 homolog 2), both act as histone-lysine N-methyltransferases that specifically trimethylate 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. They mainly function in heterochromatin regions, thereby playing central roles in the establishment of constitutive heterochromatin at pericentric and telomere regions. EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, lysine N-methyltransferase 1D, or KMT1D) and EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C, KMT1C, or protein G9a), both act as histone-lysine N-methyltransferases that specifically mono- and dimethylate 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. This family also includes the pre-SET domain, which is found in a number of histone methyltransferases (HMTase), N-terminal to the SET domain. Pre-SET domain is a zinc binding motif which contains 9 conserved cysteines that coordinate three zinc ions. It is thought that this region plays a structural role in stabilizing SET domains. Most family members, except for Arabidopsis thaliana SUVH9, contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380936 [Multi-domain]  Cd Length: 217  Bit Score: 215.70  E-value: 8.48e-72
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12854173   1 CPNRIVQKGTQYSLCIFRTSNGcGWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQFYDNKGITYLFDLDYESD----- 75
Cdd:cd10538  78 CKNRVVQRGLQARLQVFRTSKK-GWGVRSLEFIPKGSFVCEYVGEVITTSEADRRGKIYDKSGGSYLFDLDEFSDsdgdg 156

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 12854173  76 -EFTVDAARYGNVSHFVNHSCDPNLQVFSVFIDNLDTRLPRIALFSTRTINAGEELTFDYQ 135
Cdd:cd10538 157 eELCVDATFCGNVSRFINHSCDPNLFPFNVVIDHDDLRYPRIALFATRDILPGEELTFDYG 217
SET_SUV39H_Clr4-like cd20073
SET domain (including pre-SET and post-SET domains) found in of Schizosaccharomyces pombe H3K9 ...
 1-171 5.64e-54

SET domain (including pre-SET and post-SET domains) found in of Schizosaccharomyces pombe H3K9 methyltransferase Clr4, and similar proteins; This subfamily contains fission yeast Schizosaccharomyces pombe H3K9 methyltransferase Clr4 (also known as Suv39h), the sole homolog of the mammalian SUV39H1 and SUV39H2 enzymes, that has a critical role in preventing aberrant heterochromatin formation. It is known to di- and tri-methylate Lys-9 of histone H3, a central heterochromatic histone modification, with its specificity profile most similar to that of the human SUV39H2 homolog.


Pssm-ID: 380999 [Multi-domain]  Cd Length: 259  Bit Score: 171.60  E-value: 5.64e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12854173   1 CPNRIVQKGTQYSLCIFRTSNGcGWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQFYDNKGITYLFDLDYESDE---- 76
Cdd:cd20073  82 CPNRVVQRGRKLPLEIFKTKHK-GWGLRCPRFIKAGTFIGVYLGEVITQSEAEIRGKKYDNVGVTYLFDLDLFEDQvdey 160

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12854173  77 FTVDAARYGNVSHFVNHSCDPNLQVFSVFIDNLDTRLPRIALFSTRTINAGEELTFDY-------QMKGSGEASSDSIDH 149
Cdd:cd20073 161 YTVDAQYCGDVTRFINHSCDPNLAIYSVLRDKSDSKIYDLAFFAIKDIPALEELTFDYsgrnnfdQLGFIGNRSNSKYIN 240

                       170       180
                ....*....|....*....|..
gi 12854173 150 SPAKKrvrtQCKCGAETCRGYL 171
Cdd:cd20073 241 LKNKR----PCYCGSANCRGWL 258
SET_SUV39H_DIM5-like cd19473
SET domain (including pre-SET domain) found in Neurospora crassa (DIM-5) and similar proteins; ...
 1-171 3.10e-51

SET domain (including pre-SET domain) found in Neurospora crassa (DIM-5) and similar proteins; This subfamily contains Neurospora crassa DIM-5 (also termed H3-K9-HMTase dim-5, or HKMT) which functions as histone-lysine N-methyltransferase that specifically trimethylates histone H3 to form H3K9me3.


Pssm-ID: 380996 [Multi-domain]  Cd Length: 274  Bit Score: 165.18  E-value: 3.10e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12854173   1 CPNRIVQKGTQYSLCIFRTSNGCGWGVKTLVKIKRMSFVMEYVGEVITSEEAERRgqfYDNKGIT-----YLFDLDYESD 75
Cdd:cd19473  94 CPNRVVERGRKVPLQIFRTSDGRGWGVRSTVDIKRGQFVDCYVGEIITPEEAQRR---RDAATIAqrkdvYLFALDKFSD 170

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12854173  76 E-----------FTVDAARYGNVSHFVNHSCDPNLQVFSVFIDNLDTRLPRIALFSTRTINAGEELTFDYQmkgSGEASS 144
Cdd:cd19473 171 PdsldprlrgdpYEIDGEFMSGPTRFINHSCDPNLRIFARVGDHADKHIHDLAFFAIKDIPRGTELTFDYV---DGVTGL 247

                       170       180
                ....*....|....*....|....*..
gi 12854173 145 DSIDHSPAKKRVRTQCKCGAETCRGYL 171
Cdd:cd19473 248 DDDAGDEEKEKEMTKCLCGSPKCRGYL 274
SET_EHMT cd10543
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 1-168 7.45e-50

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase EHMT1, EHMT2 and similar proteins; This family includes EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, lysine N-methyltransferase 1D, or KMT1D) and EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C, KMT1C, or protein G9a), both act as histone-lysine N-methyltransferases that specifically mono- and dimethylate 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380941 [Multi-domain]  Cd Length: 231  Bit Score: 160.20  E-value: 7.45e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12854173   1 CPNRIVQKGTQYSLCIFRTsNGCGWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGqfyDNkgiTYLFDLD-YESDEFTV 79
Cdd:cd10543  80 CRNRVVQNGIRYRLQLFRT-RGMGWGVRALQDIPKGTFVCEYIGELISDSEADSRE---DD---SYLFDLDnKDGETYCI 152

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12854173  80 DAARYGNVSHFVNHSCDPNLQVFSVFIDNLDTRLPRIALFSTRTINAGEELTFDYqmkgsGEASSDSidhspakKRVRTQ 159
Cdd:cd10543 153 DARRYGNISRFINHLCEPNLIPVRVFVEHQDLRFPRIAFFASRDIKAGEELGFDY-----GEKFWRI-------KGKYFT 220


                ....*....
gi 12854173 160 CKCGAETCR 168
Cdd:cd10543 221 CRCGSPKCK 229
SET_SETDB1 cd10517
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) ...
 1-171 2.46e-45

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and similar proteins; SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes.


Pssm-ID: 380915 [Multi-domain]  Cd Length: 288  Bit Score: 150.52  E-value: 2.46e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12854173   1 CPNRIVQKGTQYSLCIFRTSNGcGWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQFYDNKgitYLFDLD--------- 71
Cdd:cd10517 118 CYNRVVQNGLQVRLQVFKTEKK-GWGIRCLDDIPKGSFVCIYAGQILTEDEANEEGLQYGDE---YFAELDyievveklk 193

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12854173  72 --YESDE----FTVDAARYGNVSHFVNHSCDPNLQVFSVFIDNLDTRLPRIALFSTRTINAGEELTFDYQMkgsgeassd 145
Cdd:cd10517 194 egYESDVeehcYIIDAKSEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASRYIRAGTELTWDYNY--------- 264

                       170       180
                ....*....|....*....|....*.
gi 12854173 146 SIDHSPAKKRvrtQCKCGAETCRGYL 171
Cdd:cd10517 265 EVGSVPGKVL---YCYCGSSNCRGRL 287
SET_SETMAR cd10544
SET domain (including pre-SET and post-SET domains) found in SET domain and mariner ...
 1-171 2.60e-45

SET domain (including pre-SET and post-SET domains) found in SET domain and mariner transposase fusion protein (SETMAR) and similar proteins; SETMAR (also termed metnase) is a DNA-binding protein that is indirectly recruited to sites of DNA damage through protein-protein interactions. It has a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity. SETMAR also acts as a histone-lysine N-methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3. It specifically mediates dimethylation of H3 'Lys-36' at sites of DNA double-strand break and may recruit proteins required for efficient DSB repair through non-homologous end-joining.


Pssm-ID: 380942 [Multi-domain]  Cd Length: 254  Bit Score: 149.37  E-value: 2.60e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12854173   1 CPNRIVQKGTQYSLCIFRTSNGcGWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQFYDNKGITYLFDL-DYESD---- 75
Cdd:cd10544  79 CQNRVVQNGLQFKLQVFKTPKK-GWGLRTLEFIPKGRFVCEYAGEVIGFEEARRRTKSQTKGDMNYIIVLrEHLSSgkvl 157

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12854173  76 EFTVDAARYGNVSHFVNHSCDPNLQVFSVFIDNLdtrLPRIALFSTRTINAGEELTFDYqmkgSGEASSDSIDHSPAKKR 155
Cdd:cd10544 158 ETFVDPTYIGNIGRFLNHSCEPNLFMVPVRVDSM---VPKLALFAARDIVAGEELSFDY----SGEFSNSVESVTLARQD 230

                       170
                ....*....|....*....
gi 12854173 156 V---RTQCKCGAETCRGYL 171
Cdd:cd10544 231 EsksRKPCLCGAENCRGFL 249
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 12-141 1.10e-41

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 135.93  E-value: 1.10e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12854173     12 YSLCIFRtSNGCGWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQFYDNKGI--TYLFDLDyesDEFTVDAARYGNVSH 89
Cdd:smart00317   1 NKLEVFK-SPGKGWGVRATEDIPKGEFIGEYVGEIITSEEAEERPKAYDTDGAkaFYLFDID---SDLCIDARRKGNLAR 76

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 12854173     90 FVNHSCDPNLQVFSVFIDNLDtrlpRIALFSTRTINAGEELTFDYQMKGSGE 141
Cdd:smart00317  77 FINHSCEPNCELLFVEVNGDD----RIVIFALRDIKPGEELTIDYGSDYANE 124
SET_EHMT1 cd10535
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 1-168 6.67e-41

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins; EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, or lysine N-methyltransferase 1D (KMT1D)) acts as a histone-lysine N-methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380933 [Multi-domain]  Cd Length: 231  Bit Score: 137.37  E-value: 6.67e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12854173   1 CPNRIVQKGTQYSLCIFRTsNGCGWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQfydnkgITYLFDLDYESDE-FTV 79
Cdd:cd10535  80 CRNRVVQNGLRARLQLYRT-RDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREE------DSYLFDLDNKDGEvYCI 152

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12854173  80 DAARYGNVSHFVNHSCDPNLQVFSVFIDNLDTRLPRIALFSTRTINAGEELTFDYqmkgsGEASSDSidhspakKRVRTQ 159
Cdd:cd10535 153 DARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDY-----GERFWDI-------KGKLFS 220


                ....*....
gi 12854173 160 CKCGAETCR 168
Cdd:cd10535 221 CRCGSPKCR 229
SET_SETD2 cd19172
SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and ...
 16-171 2.60e-39

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and similar proteins; SETD2 (also termed HIF-1, huntingtin yeast partner B, huntingtin-interacting protein 1 (HIP-1), huntingtin-interacting protein B, lysine N-methyltransferase 3A or protein-lysine N-methyltransferase SETD2) acts as histone-lysine N-methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. It has been shown that methylation is a posttranslational modification of dynamic microtubules and that SETD2 methylates alpha-tubulin at lysine 40, the same lysine that is marked by acetylation on microtubules. Methylation of microtubules occurs during mitosis and cytokinesis and can be ablated by SETD2 deletion, which causes mitotic spindle and cytokinesis defects, micronuclei, and polyploidy.


Pssm-ID: 380949 [Multi-domain]  Cd Length: 142  Bit Score: 130.39  E-value: 2.60e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12854173  16 IFRTSNGcGWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQFYDNKGITYLFDLDYESDEFtVDAARYGNVSHFVNHSC 95
Cdd:cd19172   6 VFRTEKK-GWGLRAAEDLPKGTFVIEYVGEVLDEKEFKRRMKEYAREGNRHYYFMALKSDEI-IDATKKGNLSRFINHSC 83

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 12854173  96 DPN--LQVFSVfidnldTRLPRIALFSTRTINAGEELTFDYQMKGSGEAssdsidhspAKKrvrtqCKCGAETCRGYL 171
Cdd:cd19172  84 EPNceTQKWTV------NGELRVGFFAKRDIPAGEELTFDYQFERYGKE---------AQK-----CYCGSPNCRGYI 141
SET_EHMT2 cd10533
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 1-168 1.53e-38

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 2 (EHMT2) and similar proteins; EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C (KMT1C), or protein G9a) acts as a histone-lysine N-methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380931 [Multi-domain]  Cd Length: 239  Bit Score: 131.68  E-value: 1.53e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12854173   1 CPNRIVQKGTQYSLCIFRTSNgCGWGVKTLVKIKRMSFVMEYVGEVITSEEAERRgqfydnKGITYLFDLDYESDE-FTV 79
Cdd:cd10533  80 CKNRVVQSGIKVRLQLYRTAK-MGWGVRALQTIPQGTFICEYVGELISDAEADVR------EDDSYLFDLDNKDGEvYCI 152

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12854173  80 DAARYGNVSHFVNHSCDPNLQVFSVFIDNLDTRLPRIALFSTRTINAGEELTFDYqmkgsGEASSDsidhspAKKRVRTq 159
Cdd:cd10533 153 DARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDY-----GDRFWD------IKSKYFT- 220


                ....*....
gi 12854173 160 CKCGAETCR 168
Cdd:cd10533 221 CQCGSEKCK 229
SET_AtSUVH-like cd10545
SET domain found in Arabidopsis thaliana histone H3-K9 methyltransferases (SUVHs) and similar ...
 1-134 1.16e-37

SET domain found in Arabidopsis thaliana histone H3-K9 methyltransferases (SUVHs) and similar proteins; Arabidopsis thaliana SUVH protein (also termed suppressor of variegation 3-9 homolog protein) is a histone-lysine N-methyltransferase that methylates 'Lys-9' of histone H3. H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression. Some family members contain a post-SET domain which binds a Zn2+ ion. Most family members, except for Arabidopsis thaliana SUVH9, contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380943 [Multi-domain]  Cd Length: 232  Bit Score: 129.06  E-value: 1.16e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12854173   1 CPNRIVQKGTQYSLCIFRTSNGcGWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQ----------FYDNKGITYLFDL 70
Cdd:cd10545  75 CYNRVTQKGLRYRLEVFKTAER-GWGVRSWDSIPAGSFICEYVGELLDTSEADTRSGnddylfdidnRQTNRGWDGGQRL 153

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 12854173  71 DYESD-------------EFTVDAARYGNVSHFVNHSCDPNLQVFSVFIDNLDTRLPRIALFSTRTINAGEELTFDY 134
Cdd:cd10545 154 DVGMSdgerssaedeessEFTIDAGSFGNVARFINHSCSPNLFVQCVLYDHNDLRLPRVMLFAADNIPPLQELTYDY 230
SET_SETD2-like cd10531
SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), ...
 16-168 1.68e-37

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2), ASH1-like protein (ASH1L) and similar proteins; This family includes SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2) and ASH1-like protein (ASH1L), which function as histone-lysine N-methyltransferases. SETD2 specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. NSD2 shows histone H3 'Lys-27' (H3K27me) methyltransferase activity. ASH1L specifically methylates 'Lys-36' of histone H3 (H3K36me). The family also includes Arabidopsis thaliana ASH1-related protein 3 (ASHR3) and similar proteins.


Pssm-ID: 380929  Cd Length: 136  Bit Score: 125.45  E-value: 1.68e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12854173  16 IFRTSNgCGWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQFYDNKGITYLFDLDYESDEFtVDAARYGNVSHFVNHSC 95
Cdd:cd10531   4 LFRTEK-KGWGVKAKEDIQKGEFIIEYVGEVIDKKEFKERLDEYEELGKSNFYILSLSDDVV-IDATRKGNLSRFINHSC 81

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 12854173  96 DPNL--QVFSVFIDnldtrlPRIALFSTRTINAGEELTFDYQMKGSGEASsdsidhspakkrvrTQCKCGAETCR 168
Cdd:cd10531  82 EPNCetQKWIVNGE------YRIGIFALRDIPAGEELTFDYNFVNYNEAK--------------QVCLCGAQNCR 136
SET_SETD1-like cd10518
SET domain (including post-SET domain) found in SET domain-containing proteins (SETD1A/SETD1B), ...
 17-168 1.97e-37

SET domain (including post-SET domain) found in SET domain-containing proteins (SETD1A/SETD1B), histone-lysine N-methyltransferases (KMT2A/KMT2B/KMT2C/KMT2D) and similar proteins; This family includes SET domain-containing protein 1A (SETD1A), 1B (SETD1B), as well as histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B), 2C (KMT2C), 2D (KMT2D). These proteins are histone-lysine N-methyltransferases (EC 2.1.1.43) that specifically methylate 'Lys-4' of histone H3 (H3K4me).


Pssm-ID: 380916  Cd Length: 150  Bit Score: 125.79  E-value: 1.97e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12854173  17 FRTSNGCGWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQFYDNKGI--TYLFDLDyesDEFTVDAARYGNVSHFVNHS 94
Cdd:cd10518  18 VGKSGIHGWGLFAKRPIAAGEMVIEYVGEVIRPIVADKREKRYDEEGGggTYMFRID---EDLVIDATKKGNIARFINHS 94

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 12854173  95 CDPNLQVFSVFIDNLDtrlpRIALFSTRTINAGEELTFDYQMkgsgeassdsidhsPAKKRVRTQCKCGAETCR 168
Cdd:cd10518  95 CDPNCYAKIITVDGEK----HIVIFAKRDIAPGEELTYDYKF--------------PIEDEEKIPCLCGAPNCR 150
SET_ASH1L cd19174
SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ...
 17-172 7.56e-37

SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ASH1L (EC 2.1.1.43; also termed absent small and homeotic disks protein 1 homolog, KMT2H, or lysine N-methyltransferase 2H) acts as histone-lysine N-methyltransferase that specifically methylates 'Lys-36' of histone H3 (H3K36me). It plays important roles in development; heterozygous mutation of ASH1L is associated with severe intellectual disability (ID) and multiple congenital anomaly (MCA).


Pssm-ID: 380951 [Multi-domain]  Cd Length: 141  Bit Score: 123.94  E-value: 7.56e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12854173  17 FRTSNgCGWGVKTLVKIKRMSFVMEYVGEVITSEEAERR--GQFYDNKGiTYLFDLDyesDEFTVDAARYGNVSHFVNHS 94
Cdd:cd19174   5 FRTED-KGWGVRTKEPIKAGQFIIEYVGEVVSEQEFRRRmiEQYHNHSH-HYCLNLD---SGMVIDGYRMGNEARFVNHS 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12854173  95 CDPN--LQVFSVfidnldTRLPRIALFSTRTINAGEELTFDYQMkgsgeassdsidHSPAKKRVrTQCKCGAETCRGYLN 172
Cdd:cd19174  80 CDPNceMQKWSV------NGVYRIGLFALKDIPAGEELTYDYNF------------HSFNVEKQ-QPCKCGSPNCRGVIG 140
SET_NSD cd19173
SET domain (including post-SET domain) found in nuclear SET domain-containing proteins, NSD1, ...
 16-171 3.05e-36

SET domain (including post-SET domain) found in nuclear SET domain-containing proteins, NSD1, NSD2, NSD3 and similar proteins; The nuclear receptor-binding SET Domain (NSD) family of histone H3 lysine 36 methyltransferases is comprised of NSD1, NSD2, and NSD3, which are primarily known to be involved in chromatin integrity and gene expression through mono-, di-, or tri-methylating lysine 36 of histone H3 (H3K36), respectively. NSD1 (EC 2.1.1.43; also termed histone-lysine N-methyltransferase H3 lysine-36 and H4 lysine-20 specific, androgen receptor coactivator 267 kDa protein (ARA267), androgen receptor-associated protein of 267 kDa, H3-K36-HMTase, H4-K20-HMTase, lysine N-methyltransferase 3B (KMT3B) or NR-binding SET domain-containing protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4. NSD2 (EC 2.1.1.43; also termed multiple myeloma SET domain-containing protein (MMSET), protein trithorax-5 (TRX5), or wolf-Hirschhorn syndrome candidate 1 protein (WHSC1)) acts as histone-lysine N-methyltransferase with histone H3 'Lys-27' (H3K27me) methyltransferase activity. NSD3 (EC 2.1.1.43; also termed protein whistle, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, Wolf-Hirschhorn syndrome candidate 1-like protein 1 (WHSC1L1), or WHSC1-like protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-4' and 'Lys-27' of histone H3.


Pssm-ID: 380950 [Multi-domain]  Cd Length: 142  Bit Score: 122.42  E-value: 3.05e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12854173  16 IFRTSNGcGWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQFYDNKGITYLFDLDYESDeFTVDAARYGNVSHFVNHSC 95
Cdd:cd19173   6 PFKTGDR-GWGLRTKRDIKKGDFVIEYVGELIDEEECRRRLKKAHENNITNFYMLTLDKD-RIIDAGPKGNLSRFMNHSC 83

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 12854173  96 DPNL--QVFSVfidNLDTrlpRIALFSTRTINAGEELTFDYQMKGSGEAssdsidhspakkrvRTQCKCGAETCRGYL 171
Cdd:cd19173  84 QPNCetQKWTV---NGDT---RVGLFAVRDIPAGEELTFNYNLDCLGNE--------------KKVCRCGAPNCSGFL 141
SET_EZH cd10519
SET domain found in enhancer of zeste homolog 1 (EZH1), zeste homolog 2 (EZH2) and similar ...
 20-134 4.10e-35

SET domain found in enhancer of zeste homolog 1 (EZH1), zeste homolog 2 (EZH2) and similar proteins; The family includes EZH1 and EZH2. EZH1 (EC 2.1.1.43; also termed ENX-2, or histone-lysine N-methyltransferase EZH1) is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. EZH2 (EC 2.1.1.43; also termed lysine N-methyltransferase 6, ENX-1, or histone-lysine N-methyltransferase EZH2) is a catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Both, EZH1 and EZH2, can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively.


Pssm-ID: 380917  Cd Length: 117  Bit Score: 118.89  E-value: 4.10e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12854173  20 SNGCGWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQFYDNKGITYLFDLDyesDEFTVDAARYGNVSHFVNHSCDPNL 99
Cdd:cd10519   8 SDVAGWGLFLKEPIKKDEFIGEYTGELISQDEADRRGKIYDKYNSSYLFNLN---DQFVVDATRKGNKIRFANHSSNPNC 84

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 12854173 100 Q--VFSVFIDNldtrlpRIALFSTRTINAGEELTFDY 134
Cdd:cd10519  85 YakVMMVNGDH------RIGIFAKRDIEAGEELFFDY 115
SET_ASHR3-like cd19175
SET domain (including post-SET domain) found in Arabidopsis thaliana ASH1-related protein 3 ...
 20-171 6.23e-34

SET domain (including post-SET domain) found in Arabidopsis thaliana ASH1-related protein 3 (ASHR3) and similar proteins; This family includes Arabidopsis thaliana ASH1-related protein 3 (ASHR3, also termed protein SET DOMAIN GROUP 4 or protein stamen loss), ASH1 homolog 3 (ASHH3, also termed protein SET DOMAIN GROUP 7) and homolog 4 (ASHH4, also termed protein SET DOMAIN GROUP 24). They all function as histone-lysine N-methyltransferases (EC 2.1.1.43).


Pssm-ID: 380952 [Multi-domain]  Cd Length: 139  Bit Score: 116.75  E-value: 6.23e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12854173  20 SNGCGWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQFYDNKGIT--YLFDLDYesdEFTVDAARYGNVSHFVNHSCDP 97
Cdd:cd19175   7 TEKCGWGLVADEDINAGEFIIEYVGEVIDDKTCEERLWDMKHKGEKnfYMCEIDK---DMVIDATFKGNLSRFINHSCDP 83

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 12854173  98 NLQVFSVFIDNLDtrlpRIALFSTRTINAGEELTFDYQMKGSGEASsdsidhspakkrvrtQCKCGAETCRGYL 171
Cdd:cd19175  84 NCELQKWQVDGET----RIGVFAIRDIKKGEELTYDYQFVQFGADQ---------------DCHCGSKNCRGKL 138
SET_SETDB cd10541
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1), ...
 1-171 1.43e-30

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1), SET domain bifurcated 2 (SETDB2), and similar proteins; SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis.


Pssm-ID: 380939 [Multi-domain]  Cd Length: 236  Bit Score: 110.71  E-value: 1.43e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12854173   1 CPNRIVQKGTQYSLCIFRTSNGcGWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQFydnKGITYLFDLDY-ESDEFTV 79
Cdd:cd10541  81 CQNRLVQHGLQVRLQLFKTQNK-GWGIRCLDDIAKGTFVCIYAGKILTDDFADKEGLE---MGDEYFANLDHiEESCYII 156

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12854173  80 DAARYGNVSHFVNHSCDPNLQVFSVFIDNLDTRLPRIALFSTRTINAGEELTFDYQMkgsgEASSdsidhSPAKKRVrtq 159
Cdd:cd10541 157 DAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASKRIKAGTELTWDYNY----EVGS-----VEGKELL--- 224

                       170
                ....*....|..
gi 12854173 160 CKCGAETCRGYL 171
Cdd:cd10541 225 CCCGSNECRGRL 236
SET_NSD3 cd19212
SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing ...
 16-171 4.09e-29

SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 3 (NSD3) and similar proteins; NSD3 (EC 2.1.1.43; also termed protein whistle, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, Wolf-Hirschhorn syndrome candidate 1-like protein 1 (WHSC1L1), or WHSC1-like protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. NSD3 is amplified and overexpressed in multiple cancer types, including acute myeloid leukemia (AML), breast, lung, pancreatic and bladder cancers, as well as squamous cell carcinoma of the head and neck (SCCHN). NSD3 contributes to tumorigenesis by interacting with bromodomain-containing protein 4 (BRD4), the bromodomain and extraterminal (BET) protein, which is a potential therapeutic target in acute myeloid leukemia (AML). NSD3 is amplified in primary tumors and cell lines from breast carcinoma, and can promote the cell viability of small-cell lung cancer and pancreatic ductal adenocarcinoma. High NSD3 expression is implicated in poor grade and heavy smoking history in SCCHN. Thus, NSD3 may serve as a potential druggable target for selective cancer therapy.


Pssm-ID: 380989 [Multi-domain]  Cd Length: 142  Bit Score: 104.62  E-value: 4.09e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12854173  16 IFRTsNGCGWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQFYDNKGITYLFDLDYESDEfTVDAARYGNVSHFVNHSC 95
Cdd:cd19212   6 IIKT-ERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDR-IIDAGPKGNYSRFMNHSC 83

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 12854173  96 DPN--LQVFSVfidNLDTrlpRIALFSTRTINAGEELTFDYQMKGSGEAssdsidhspakkrvRTQCKCGAETCRGYL 171
Cdd:cd19212  84 NPNceTQKWTV---NGDV---RVGLFALCDIPAGMELTFNYNLDCLGNG--------------RTECHCGADNCSGFL 141
SET_SETDB2 cd10523
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 2 (SETDB2) ...
 1-171 4.55e-29

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 2 (SETDB2) and similar proteins; SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis.


Pssm-ID: 380921 [Multi-domain]  Cd Length: 266  Bit Score: 107.61  E-value: 4.55e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12854173   1 CPNRIVQKGTQYSLCIFRTsNGCGWGVKTLVKIKRMSFVMEYVGEVITSEEAErrgqfyDNKGITYLFDLDYESDE---- 76
Cdd:cd10523  97 CQNRVVQHGLQVRLQVFKT-EKKGWGVRCLDDIDKGTFVCIYAGRVLSRARSP------TEPLPPKLELPSENEVEvvts 169

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12854173  77 --------------FTVDAARYGNVSHFVNHSCDPNLQVFSVFIDNLDTRLPRIALFSTRTINAGEELTFDYqmkgsgea 142
Cdd:cd10523 170 wlilskkrklrenvCFLDASKEGNVGRFLNHSCCPNLFVQNVFVDTHDKNFPWVAFFTNRVVKAGTELTWDY-------- 241

                       170       180
                ....*....|....*....|....*....
gi 12854173 143 SSDSidHSPAKKRVrtQCKCGAETCRGYL 171
Cdd:cd10523 242 SYDA--GTSPEQEI--PCLCGVNKCQKKI 266
SET_NSD2 cd19211
SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) ...
 16-171 4.09e-28

SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins; NSD2 (EC 2.1.1.43; also termed multiple myeloma SET domain-containing protein (MMSET), protein trithorax-5 (TRX5), or wolf-Hirschhorn syndrome candidate 1 protein (WHSC1)) acts as histone-lysine N-methyltransferase with histone H3 'Lys-36' (H3K36me) methyltransferase activity. NSD2 has been shown to mediate di- and trimethylation of H3K36 and dimethylation of H4K20 in different systems, and has been characterized as a transcriptional repressor interacting with histone deacetylase HDAC1 and histone demethylase LSD1. NSD2 mediates constitutive NF-kappaB signaling for cancer cell proliferation, survival and tumor growth. It is highly overexpressed in several types of human cancers, including small-cell lung cancers, neuroblastoma, carcinomas of stomach and colon, and bladder cancers, and its overexpression tends to be associated with tumor aggressiveness. WHSC1 is frequently deleted in Wolf-Hirschhorn syndrome (WHS).


Pssm-ID: 380988 [Multi-domain]  Cd Length: 142  Bit Score: 101.99  E-value: 4.09e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12854173  16 IFRTSnGCGWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQFYDNKGITYLFDLDYESDEFtVDAARYGNVSHFVNHSC 95
Cdd:cd19211   6 IIKTE-GKGWGLIAKRDIKKGEFVNEYVGELIDEEECMARIKHAHENDITHFYMLTIDKDRI-IDAGPKGNYSRFMNHSC 83

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 12854173  96 DPN--LQVFSVfidNLDTrlpRIALFSTRTINAGEELTFDYQMKGSGEAssdsidhspakkrvRTQCKCGAETCRGYL 171
Cdd:cd19211  84 QPNceTQKWTV---NGDT---RVGLFAVCDIPAGTELTFNYNLDCLGNE--------------KTVCRCGAPNCSGFL 141
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 24-134 1.27e-27

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 99.90  E-value: 1.27e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12854173    24 GWGVKTLVKIKRMSFVMEYVGE-VITSEEAERRGQFY-----DNKGITYLFDLDyESDEFTVD--AARYGNVSHFVNHSC 95
Cdd:pfam00856   1 GRGLFATEDIPKGEFIGEYVEVlLITKEEADKRELLYydkleLRLWGPYLFTLD-EDSEYCIDarALYYGNWARFINHSC 79

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 12854173    96 DPNLQVFSVFIDnldtRLPRIALFSTRTINAGEELTFDY 134
Cdd:pfam00856  80 DPNCEVRVVYVN----GGPRIVIFALRDIKPGEELTIDY 114
SET_NSD1 cd19210
SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing ...
 16-171 1.96e-27

SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins; NSD1 (EC 2.1.1.43; also termed Histone-lysine N-methyltransferase H3 lysine-36 and H4 lysine-20 specific, androgen receptor coactivator 267 kDa protein (ARA267), androgen receptor-associated protein of 267 kDa, H3-K36-HMTase, H4-K20-HMTase, lysine N-methyltransferase 3B (KMT3B), or NR-binding SET domain-containing protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4. NSD1 is altered in approximately 10% of head and neck cancer patients with 55% decrease in risk of death in NSD1-mutated versus non-mutated patients; its disruption promotes favorable chemotherapeutic responses linked to hypomethylation.


Pssm-ID: 380987 [Multi-domain]  Cd Length: 142  Bit Score: 100.00  E-value: 1.96e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12854173  16 IFRTSnGCGWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQFYDNKGITYLFDLDYESDEFtVDAARYGNVSHFVNHSC 95
Cdd:cd19210   6 IFRTL-GRGWGLRCKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTLDKDRI-IDAGPKGNYARFMNHCC 83

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 12854173  96 DPN--LQVFSVfidNLDTrlpRIALFSTRTINAGEELTFDYQMKGSGEAssdsidhspakkrvRTQCKCGAETCRGYL 171
Cdd:cd19210  84 QPNceTQKWTV---NGDT---RVGLFALCDIKAGTELTFNYNLECLGNG--------------KTVCKCGAPNCSGFL 141
SET_KMT2A_2B cd19170
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), ...
 39-172 3.43e-27

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B) and similar proteins; This family includes KMT2A and KMT2B. Both KMT2A (also termed ALL-1 or CXXC7 or MLL or MLL1 or TRX1 or HRX) and KMT2B (also termed MLL4 or TRX2) act as histone methyltransferases that methylate 'Lys-4' of histone H3 (H3K4me).


Pssm-ID: 380947 [Multi-domain]  Cd Length: 152  Bit Score: 99.77  E-value: 3.43e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12854173  39 VMEYVGEVITSEEAERRGQFYDNKGI-TYLFDLDyesDEFTVDAARYGNVSHFVNHSCDPNLQVFSVFIDNLDtrlpRIA 117
Cdd:cd19170  40 VIEYAGEVIRSVLTDKREKYYESKGIgCYMFRID---DDEVVDATMHGNAARFINHSCEPNCYSRVVNIDGKK----HIV 112

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 12854173 118 LFSTRTINAGEELTFDYQMkgsgeassdsidhspAKKRVRTQCKCGAETCRGYLN 172
Cdd:cd19170 113 IFALRRILRGEELTYDYKF---------------PIEDVKIPCTCGSKKCRKYLN 152
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
18-169 6.53e-27

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 98.50  E-value: 6.53e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12854173  18 RTSNGCGWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQFyDNKGITYLFDLDyesDEFTVDAARYGNVSHFVNHSCDP 97
Cdd:COG2940  11 RPSPIHGRGVFATRDIPKGTLIGEYPGEVITWAEAERREPH-KEPLHTYLFELD---DDGVIDGALGGNPARFINHSCDP 86

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 12854173  98 NLQvfsvfidnLDTRLPRIALFSTRTINAGEELTFDYqmkgsgeasSDSIDHSPAKkrvrtqCKCGaeTCRG 169
Cdd:COG2940  87 NCE--------ADEEDGRIFIVALRDIAAGEELTYDY---------GLDYDEEEYP------CRCP--NCRG 133
SET_EZH2 cd19218
SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins; EZH2 (EC 2.1.1.43) ...
 20-135 2.83e-26

SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins; EZH2 (EC 2.1.1.43), also termed lysine N-methyltransferase 6, or ENX-1, or histone-lysine N-methyltransferase EZH2, is a catalytic subunit of the polycomb repressive complex 2 (PRC2)/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. It can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. PRC2 is involved in several cancers; EZH2 is overexpressed in breast, liver and prostate cancer, while point mutations in EZH2 alter the substrate preference and product specificity of PRC2 in Non-Hodgkin lymphomas (NHLs). Thus, PRC2 is a popular target for cancer therapeutics.


Pssm-ID: 380995  Cd Length: 120  Bit Score: 96.52  E-value: 2.83e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12854173  20 SNGCGWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQFYDNKGITYLFDLDyesDEFTVDAARYGNVSHFVNHSCDPNL 99
Cdd:cd19218  11 SDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLN---NDFVVDATRKGNKIRFANHSVNPNC 87

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 12854173 100 QVfSVFIDNLDTrlpRIALFSTRTINAGEELTFDYQ 135
Cdd:cd19218  88 YA-KVMMVNGDH---RIGIFAKRAIQTGEELFFDYR 119
SET_SETD1 cd19169
SET domain (including post-SET domain) found in SET domain-containing protein 1 (SETD1) and ...
 17-168 5.35e-26

SET domain (including post-SET domain) found in SET domain-containing protein 1 (SETD1) and similar proteins; This family includes SET domain-containing protein 1A (SETD1A) and SET domain-containing protein 1B (SETD1B). These proteins are histone-lysine N-methyltransferases that specifically methylate 'Lys-4' of histone H3 (H3K4me) when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated.


Pssm-ID: 380946  Cd Length: 148  Bit Score: 96.64  E-value: 5.35e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12854173  17 FRTSNGCGWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQFYDNKGI--TYLFDLDyesDEFTVDAARYGNVSHFVNHS 94
Cdd:cd19169  17 FAKSRIHDWGLFALEPIAADEMVIEYVGQVIRQSVADEREKRYEAIGIgsSYLFRVD---DDTIIDATKCGNLARFINHS 93

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 12854173  95 CDPNLQVFSVFIDNLDtrlpRIALFSTRTINAGEELTFDYqmKGSGEasSDSIDhspakkrvrtqCKCGAETCR 168
Cdd:cd19169  94 CNPNCYAKIITVESQK----KIVIYSKRPIAVNEEITYDY--KFPIE--DEKIP-----------CLCGAPQCR 148
SET_KMT2C_2D cd19171
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), ...
 20-171 5.98e-26

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins; This family includes KMT2C and KMT2D. Both, KMT2C (also termed HALR or MLL3) and KMT2D (also termed ALR or MLL2), act as histone methyltransferases that methylate 'Lys-4' of histone H3 (H3K4me). They are subunits of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation.


Pssm-ID: 380948 [Multi-domain]  Cd Length: 153  Bit Score: 96.73  E-value: 5.98e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12854173  20 SNGCGWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQFYD--NKGItYLFDLDyesDEFTVDAARYGNVSHFVNHSCDP 97
Cdd:cd19171  21 SRIQGLGLYAARDIEKHTMVIEYIGEIIRNEVANRREKIYEsqNRGI-YMFRID---NDWVIDATMTGGPARYINHSCNP 96

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 12854173  98 NLQVFSVFIDnldtRLPRIALFSTRTINAGEELTFDYQMKGSGEASsdsidhspakkrvRTQCKCGAETCRGYL 171
Cdd:cd19171  97 NCVAEVVTFD----KEKKIIIISNRRIAKGEELTYDYKFDFEDDQH-------------KIPCLCGAPNCRKWM 153
SET_LegAS4-like cd10522
SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and ...
 21-134 3.63e-25

SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and similar proteins; LegAS4 is a type IV secretion system effector of Legionella pneumophila. It contains a SET domain that is involved in the modification of Lys4 of histone H3 (H3K4) in the nucleolus of the host cell, thereby enhancing heterochromatic rDNA transcription. It also contains an ankyrin repeat domain of unknown function at its C-terminal region.


Pssm-ID: 380920 [Multi-domain]  Cd Length: 122  Bit Score: 93.56  E-value: 3.63e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12854173  21 NGCGWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQFYdnKGITYLFDLDYesDEFTVDAARYGNVSHFVNHSCDPNLQ 100
Cdd:cd10522  11 SHNGLGLFAAETIAKGEFVGEYTGEVLDRWEEDRDSVYH--YDPLYPFDLNG--DILVIDAGKKGNLTRFINHSDQPNLE 86

                        90       100       110
                ....*....|....*....|....*....|....
gi 12854173 101 VFSVFIDnldtRLPRIALFSTRTINAGEELTFDY 134
Cdd:cd10522  87 LIVRTLK----GEQHIGFVAIRDIKPGEELFISY 116
SET_SET1 cd20072
SET domain (including post-SET domain) found in catalytic component of the Saccharomyces ...
 25-168 2.03e-23

SET domain (including post-SET domain) found in catalytic component of the Saccharomyces cerevisiae COMPASS complex and similar proteins; The family contains mostly fungal SET domains, including SET1 found in the catalytic component of the Saccharomyces cerevisiae COMPASS (complex of proteins associated with Set1). SET1 is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me), when part of the SET1 histone methyltransferase (HMT) complex. The activity of this catalytic domain is established through forming a complex with a set of core proteins; it is extensively contacted by Cps60 (Bre2), Cps50 (Swd1), and Cps30 (Swd3).


Pssm-ID: 380998  Cd Length: 148  Bit Score: 89.79  E-value: 2.03e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12854173  25 WGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQFYDNKGI--TYLFDLDyesDEFTVDAARYGNVSHFVNHSCDPNLQVF 102
Cdd:cd20072  25 WGLYAMENISAKDMVIEYVGEVIRQQVADEREKRYLRQGIgsSYLFRID---DDTVVDATKKGNIARFINHCCDPNCTAK 101

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 12854173 103 SVFIDNLDtrlpRIALFSTRTINAGEELTFDYQMKgsgeassdsidhspaKKRVRTQCKCGAETCR 168
Cdd:cd20072 102 IIKVEGEK----RIVIYAKRDIAAGEELTYDYKFP---------------REEDKIPCLCGAPNCR 148
SET_EZH1 cd19217
SET domain found in enhancer of zeste homolog 1 (EZH1) and similar proteins; EZH1 (EC 2.1.1.43) ...
 7-135 2.13e-23

SET domain found in enhancer of zeste homolog 1 (EZH1) and similar proteins; EZH1 (EC 2.1.1.43), also termed ENX-2, or histone-lysine N-methyltransferase EZH1, is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. It can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively.


Pssm-ID: 380994  Cd Length: 136  Bit Score: 89.74  E-value: 2.13e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12854173   7 QKGTQYSLcIFRTSNGCGWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQFYDNKGITYLFDLDyesDEFTVDAARYGN 86
Cdd:cd19217   1 QRGLKKHL-LLAPSDVAGWGTFIKESVQKNEFISEYCGELISQDEADRRGKVYDKYMSSFLFNLN---NDFVVDATRKGN 76

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 12854173  87 VSHFVNHSCDPNLQVFSVFIDNLDtrlpRIALFSTRTINAGEELTFDYQ 135
Cdd:cd19217  77 KIRFANHSVNPNCYAKVVMVNGDH----RIGIFAKRAIQQGEELFFDYR 121
SET_KMT2A cd19206
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A) ...
 4-172 2.35e-23

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A) and similar proteins; KMT2A (EC2.1.1.43; also termed lysine N-methyltransferase 2A, ALL-1, CXXC-type zinc finger protein 7 (CXXC7), myeloid/lymphoid or mixed-lineage leukemia (MLL), myeloid/lymphoid or mixed-lineage leukemia protein 1 (MLL1), trithorax-like protein (TRX1), or zinc finger protein HRX) acts as a histone methyltransferase that plays an essential role in early development and hematopoiesis. It is a catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac).


Pssm-ID: 380983 [Multi-domain]  Cd Length: 154  Bit Score: 90.08  E-value: 2.35e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12854173   4 RIVQKGTQYSLCIFRTS-NGCGWGVKTLVKIKRMsfVMEYVGEVITSEEAERRGQFYDNKGI-TYLFDLDyesDEFTVDA 81
Cdd:cd19206   6 RHLKKTSKEAVGVYRSPiHGRGLFCKRNIDAGEM--VIEYSGNVIRSILTDKREKYYDSKGIgCYMFRID---DSEVVDA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12854173  82 ARYGNVSHFVNHSCDPNlqVFSVFIdNLDTRlPRIALFSTRTINAGEELTFDYQMKGSgEASSdsidhspakkrvRTQCK 161
Cdd:cd19206  81 TMHGNAARFINHSCEPN--CYSRVI-NIDGQ-KHIVIFAMRKIYRGEELTYDYKFPIE-DASN------------KLPCN 143

                       170
                ....*....|.
gi 12854173 162 CGAETCRGYLN 172
Cdd:cd19206 144 CGAKKCRKFLN 154
SET_EZH-like cd19168
SET domain found in enhancer of zeste homolog 1 (EZH1) and zeste homolog 2 (EZH2) of polycomb ...
 23-134 1.07e-20

SET domain found in enhancer of zeste homolog 1 (EZH1) and zeste homolog 2 (EZH2) of polycomb repressive complex 2 (PRC2), and similar proteins; The family includes EZH1 and EZH2. EZH1 (EC 2.1.1.43; also termed ENX-2, or histone-lysine N-methyltransferase EZH1) is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. EZH2 (EC 2.1.1.43; also termed lysine N-methyltransferase 6, ENX-1, or histone-lysine N-methyltransferase EZH2) is a catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Both EZH1 and EZH2 can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. PRC2 is involved in several cancers; EZH2 is overexpressed in breast, liver and prostate cancer, while point mutations in EZH2 alter the substrate preference and product specificity of PRC2 in Non-Hodgkin lymphomas (NHLs). Thus, PRC2 is a popular target for cancer therapeutics.


Pssm-ID: 380945  Cd Length: 124  Bit Score: 82.24  E-value: 1.07e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12854173  23 CGWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQFYDNKGITYLFDLDyesDEFTVDAARYGNVSHFVNHSCDP----N 98
Cdd:cd19168  12 CGLGLFAAEDIKEGEFVIEYTGELISHDEGVRREHRRGDVSYLYLFEEQ---EGIWVDAAIYGNLSRYINHATDKvktgN 88

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 12854173  99 LQVFSVFidnlDTRLPRIALFSTRTINAGEELTFDY 134
Cdd:cd19168  89 CMPKIMY----VNHEWRIKFTAIKDIKIGEELFFNY 120
SET_SETD8 cd10528
SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins; SETD8 (EC 2. ...
 24-134 3.05e-20

SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins; SETD8 (EC 2.1.1.43; also termed N-lysine methyltransferase KMT5A, H4-K20-HMTase KMT5A, lysine N-methyltransferase 5A, lysine-specific methylase 5A, PR/SET domain-containing protein 07, PR-Set7 or PR/SET07) is a nucleosomal histone-lysine N-methyltransferase that specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). It plays a central role in the silencing of euchromatic genes.


Pssm-ID: 380926 [Multi-domain]  Cd Length: 141  Bit Score: 81.47  E-value: 3.05e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12854173  24 GWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQFY--DNKGITYLFDLDYESDEFTVDAA----RYGnvsHFVNHSC-D 96
Cdd:cd10528  28 GRGVIATRPFEKGDFVVEYHGDLITITEAKKREALYakDPSTGCYMYYFQYKGKTYCVDATkesgRLG---RLINHSKkK 104

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 12854173  97 PNLQVFSVFIDNldtrLPRIALFSTRTINAGEELTFDY 134
Cdd:cd10528 105 PNLKTKLLVIDG----VPHLILVAKRDIKPGEELLYDY 138
SET_SETD1B cd19205
SET domain (including post-SET domain) found in SET domain-containing protein 1B (SETD1B) and ...
 25-172 5.52e-20

SET domain (including post-SET domain) found in SET domain-containing protein 1B (SETD1B) and similar proteins; SETD1B (EC2.1.1.43), also termed lysine N-methyltransferase 2G, is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me) when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. Loss of SETD1B occurs in up to half the gastric and colorectal cancers, most commonly via SETD1B mutations, while de novo variants in SETD1B are associated with intellectual disability, epilepsy and autism.


Pssm-ID: 380982 [Multi-domain]  Cd Length: 153  Bit Score: 81.25  E-value: 5.52e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12854173  25 WGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQFYDNKGI--TYLFDLDYESdefTVDAARYGNVSHFVNHSCDPNLQVF 102
Cdd:cd19205  26 WGLFAMEPIAADEMVIEYVGQNIRQVIADMREKRYEDEGIgsSYMFRVDHDT---IIDATKCGNFARFINHSCNPNCYAK 102

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12854173 103 SVFIDNLDtrlpRIALFSTRTINAGEELTFDYQMKGSGEassdsidhspakkrvRTQCKCGAETCRGYLN 172
Cdd:cd19205 103 VITVESQK----KIVIYSKQHINVNEEITYDYKFPIEDV---------------KIPCLCGSENCRGTLN 153
SET_SETD1A cd19204
SET domain (including post-SET domain) found in SET domain-containing protein 1A (SETD1A) and ...
 25-172 1.59e-19

SET domain (including post-SET domain) found in SET domain-containing protein 1A (SETD1A) and similar proteins; SETD1A (EC2.1.1.43), also termed lysine N-methyltransferase 2F, or Set1/Ash2 histone methyltransferase complex subunit SET1, is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me), when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. Human SET domain containing protein 1A (hSETD1A) expression occurs at a high rate in hepatocellular carcinoma patients and controls tumor metastasis in breast cancer by activating MMP expression.


Pssm-ID: 380981 [Multi-domain]  Cd Length: 153  Bit Score: 80.07  E-value: 1.59e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12854173  25 WGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQFYDNKGI--TYLFDLDYESdefTVDAARYGNVSHFVNHSCDPNLQVF 102
Cdd:cd19204  26 WGLFAMEPIAADEMVIEYVGQNIRQVVADMREKRYVQEGIgsSYLFRVDHDT---IIDATKCGNLARFINHCCTPNCYAK 102

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12854173 103 SVFIDNLDtrlpRIALFSTRTINAGEELTFDYQMkgsgeassdsidhsPAKKRvRTQCKCGAETCRGYLN 172
Cdd:cd19204 103 VITIESQK----KIVIYSKQPIGVNEEITYDYKF--------------PIEDN-KIPCLCGTENCRGTLN 153
SET_KMT2B cd19207
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2B (KMT2B) ...
 4-172 3.90e-18

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2B (KMT2B) and similar proteins; KMT2B (EC2.1.1.43; also termed lysine N-methyltransferase 2B, myeloid/lymphoid or mixed-lineage leukemia protein 4 (MLL2/MLL4), trithorax homolog 2 (TRX2), or WW domain-binding protein 7 (WBP-7)), acts as a histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me). It is required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that precedes resumption of meiosis, oocyte survival and normal zygotic genome activation.


Pssm-ID: 380984 [Multi-domain]  Cd Length: 154  Bit Score: 76.60  E-value: 3.90e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12854173   4 RIVQKGTQYSLCIFRTS-NGCGWGVKTLVKIKRMsfVMEYVGEVITSEEAERRGQFYDNKGI-TYLFDLDyesDEFTVDA 81
Cdd:cd19207   6 RHLKKTSKEAVGVYRSAiHGRGLFCKRNIDAGEM--VIEYSGIVIRSVLTDKREKFYDSKGIgCYMFRID---DFDVVDA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12854173  82 ARYGNVSHFVNHSCDPNlqVFSVFIDNLDTRlpRIALFSTRTINAGEELTFDYQMkgsgeASSDSIDHSPakkrvrtqCK 161
Cdd:cd19207  81 TMHGNAARFINHSCEPN--CYSRVIHVEGQK--HIVIFALRKIYRGEELTYDYKF-----PIEDASNKLP--------CN 143

                       170
                ....*....|.
gi 12854173 162 CGAETCRGYLN 172
Cdd:cd19207 144 CGAKRCRRFLN 154
SET_KMT2D cd19209
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) ...
 24-171 1.79e-17

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins; KMT2D (EC2.1.1.43; also termed lysine N-methyltransferase 2D, ALL1-related protein (ALR), or myeloid/lymphoid or mixed-lineage leukemia protein 2 (MLL2)), acts as histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me). It is a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription. KMT2D is a subunit of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation.


Pssm-ID: 380986 [Multi-domain]  Cd Length: 155  Bit Score: 74.73  E-value: 1.79e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12854173  24 GWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQFYD--NKGItYLFDLDyesDEFTVDAARYGNVSHFVNHSCDPNLQV 101
Cdd:cd19209  27 GLGLYAAKDLEKHTMVIEYIGTIIRNEVANRREKIYEeqNRGI-YMFRIN---NEHVIDATLTGGPARYINHSCAPNCVA 102

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12854173 102 FSVFIDNLDtrlpRIALFSTRTINAGEELTFDYQMKgsgeaSSDSIDHSPakkrvrtqCKCGAETCRGYL 171
Cdd:cd19209 103 EVVTFDKED----KIIIISSRRIPKGEELTYDYQFD-----FEDDQHKIP--------CHCGAWNCRKWM 155
SET_SETD5-like cd10529
SET domain found in SET domain-containing protein 5 (SETD5), inactive histone-lysine ...
 26-134 7.34e-16

SET domain found in SET domain-containing protein 5 (SETD5), inactive histone-lysine N-methyltransferase 2E (KMT2E) and similar proteins; SETD5 is a probable transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. KMT2E (also termed inactive lysine N-methyltransferase 2E or myeloid/lymphoid or mixed-lineage leukemia protein 5 (MLL5)) associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription. The family also includes Saccharomyces cerevisiae SET domain-containing proteins, SET3 and SET4, and Schizosaccharomyces pombe SET3. Most of these family members contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380927  Cd Length: 127  Bit Score: 69.61  E-value: 7.34e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12854173  26 GVKTLVKIKRMSFVMEYVGEVITSEEAERRGQFYdNKGITYLFDLD-YESDEFTVDAARYGNVSHFVNHSCDPNLQVFSV 104
Cdd:cd10529  18 GLVATEDISPGEPILEYKGEVSLRSEFKEDNGFF-KRPSPFVFFYDgFEGLPLCVDARKYGNEARFIRRSCRPNAELRHV 96

                        90       100       110
                ....*....|....*....|....*....|..
gi 12854173 105 FIDNldTRLpRIALFSTRTINAGEELT--FDY 134
Cdd:cd10529  97 VVSN--GEL-RLFIFALKDIRKGTEITipFDY 125
SET_KMT2C cd19208
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C) ...
 24-171 2.14e-15

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C) and similar proteins; KMT2C (EC2.1.1.43; also termed lysine N-methyltransferase 2C, homologous to ALR protein (HALR) myeloid/lymphoid, or mixed-lineage leukemia protein 3 (MLL3)), acts as a histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me) and may be involved in leukemogenesis and developmental disorder. KMT2C is a catalytic subunit of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. Overexpression of KMT2C is associated with estrogen receptor-positive breast cancer; KMT2C mediates the estrogen dependence of breast cancer through regulation of estrogen receptor alpha (ERalpha) enhancer function. KMT2C is frequently mutated in certain populations with diffuse-type gastric adenocarcinomas (DGA); its loss promotes epithelial-to-mesenchymal transition (EMT) and is associated with worse overall survival.


Pssm-ID: 380985 [Multi-domain]  Cd Length: 154  Bit Score: 69.27  E-value: 2.14e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12854173  24 GWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQFYD--NKGItYLFDLDyesDEFTVDAARYGNVSHFVNHSCDPNLQV 101
Cdd:cd19208  26 GLGLYAARDIEKHTMVIEYIGTIIRNEVANRKEKLYEsqNRGV-YMFRID---NDHVIDATLTGGPARYINHSCAPNCVA 101

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12854173 102 FSVFIDnldtRLPRIALFSTRTINAGEELTFDYQMKGSGEASsdsidhspakkrvRTQCKCGAETCRGYL 171
Cdd:cd19208 102 EVVTFE----KGHKIIISSSRRIQKGEELCYDYKFDFEDDQH-------------KIPCHCGAVNCRKWM 154
SET cd08161
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, ...
 87-134 4.40e-14

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, Enhancer-of-zeste, Trithorax (SET) domain superfamily corresponds to SET domain-containing lysine methyltransferases, which catalyze site and state-specific methylation of lysine residues in histones that are fundamental in epigenetic regulation of gene activation and silencing in eukaryotic organisms. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains has been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as N-SET and C-SET. C-SET forms an unusual and conserved knot-like structure of probable functional importance. In addition to N-SET and C-SET, an insert region (I-SET) and flanking regions of high structural variability form part of the overall structure. Some family members contain a pre-SET domain, which is found in a number of histone methyltransferases (HMTase), and a post-SET domain, which harbors a zinc-binding site.


Pssm-ID: 380914 [Multi-domain]  Cd Length: 72  Bit Score: 63.42  E-value: 4.40e-14
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 12854173  87 VSHFVNHSCDPNLQVFSVFIDnldtRLPRIALFSTRTINAGEELTFDY 134
Cdd:cd08161  28 LARFINHSCEPNCEFEEVYVG----GKPRVFIVALRDIKAGEELTVDY 71
SET_SpSET3-like cd19183
SET domain (including post-SET domain) found in Schizosaccharomyces pombe SET ...
 18-135 1.68e-11

SET domain (including post-SET domain) found in Schizosaccharomyces pombe SET domain-containing protein 3 (SETD3) and similar proteins; Schizosaccharomyces pombe SETD3 functions as a transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. It is required for both, gene activation and repression.


Pssm-ID: 380960  Cd Length: 173  Bit Score: 59.34  E-value: 1.68e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12854173  18 RTSNGCGWGVKTLVKIKRMSFVMEYVGEV------ITSEE-------AERRGQFYDNKGITYlfdldyesdeftVDAARY 84
Cdd:cd19183   7 GLANASRFGLFADRPIPAGDPIQELLGEIglqseyIADPEnqyqilgAPKPHVFFHPQSPLY------------IDTRRS 74

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 12854173  85 GNVSHFVNHSCDPNLQVFSVFIDNLdtRLPRIALFSTRTINAGEELTFDYQ 135
Cdd:cd19183  75 GSVARFIRRSCRPNAELVTVASDSG--SVLKFVLYASRDISPGEEITIGWD 123
SET_KMT2E cd19182
SET domain found in inactive histone-lysine N-methyltransferase 2E (KMT2E) and similar ...
 37-134 2.87e-09

SET domain found in inactive histone-lysine N-methyltransferase 2E (KMT2E) and similar proteins; KMT2E (also termed inactive lysine N-methyltransferase 2E, myeloid/lymphoid or mixed-lineage leukemia protein 5 (MLL5)) plays a key role in hematopoiesis, spermatogenesis and cell cycle progression. It associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription. Lack of key residues in the SET domain as well as the presence of an unusually large loop in the SET-I subdomain preclude the interaction of MLL5 SET with its cofactor and substrate thus making MLL5 devoid of any in vitro methyltransferase activity on full-length histones and histone H3 peptide.


Pssm-ID: 380959  Cd Length: 129  Bit Score: 52.59  E-value: 2.87e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12854173  37 SFVMEYVGEVITSEEAERRGQFYDNKGITYLFDLDYESDEFTVDAARYGNVSHFVNHSCDPNLQVFSVFIDNldtrLPRI 116
Cdd:cd19182  31 TLIIEYRGKFMLREQFEANGYFFKRPYPFVLFYSKFHGLEMCVDARTFGNEARFIRRSCTPNAEVRHVIEDG----TIHL 106

                        90       100
                ....*....|....*....|..
gi 12854173 117 ALFSTRTINAGEELT----FDY 134
Cdd:cd19182 107 YIYSIRSIPKGTEITiafdFDY 128
SET_SETD5 cd19181
SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and ...
 37-167 4.20e-09

SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins; SETD5 is a probable transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. SETD5 loss-of-function mutations are a likely cause of a familial syndromic intellectual disability with variable phenotypic expression.


Pssm-ID: 380958  Cd Length: 150  Bit Score: 52.70  E-value: 4.20e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12854173  37 SFVMEYVGEVITSEEAERRGQFYDNKGITYLFDLDYESDEFTVDAARYGNVSHFVNHSCDPNLQVFSVFIDNldtrLPRI 116
Cdd:cd19181  31 TLIIEYRGKVMLRQQFEVNGHFFKRPYPFVLFYSKFNGVEMCVDARTFGNDARFIRRSCTPNAEVRHMIADG----MIHL 106

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 12854173 117 ALFSTRTINAGEELT--FDYqmkgsgeassdsiDHSPAKKRVRTQCKCGAETC 167
Cdd:cd19181 107 CIYAVAAIAKDAEVTiaFDY-------------EYSNCNYKVDCACHKGNRNC 146
SET_ATXR5_6-like cd10539
SET domain found in fungal protein lysine methyltransferase SET5 and similar protein; The ...
 24-134 3.07e-08

SET domain found in fungal protein lysine methyltransferase SET5 and similar protein; The family includes Arabidopsis thaliana ATXR5 and ATXR6. Both ATXR5 (also termed protein SET DOMAIN GROUP 15, or TRX-related protein 5) and ATXR6 (also termed protein SET DOMAIN GROUP 34, or TRX-related protein 6) function as histone methyltransferase that specifically monomethylates 'Lys-37' of histone H3 (H3K27me1). They are required for chromatin structure and gene silencing.


Pssm-ID: 380937  Cd Length: 138  Bit Score: 50.10  E-value: 3.07e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12854173  24 GWGVKTLVKIKRMSFVMEYVGEVITSEEAErrgqFYDNKGITYLFDLDYESDEFTVDAARYGNVSHFV----NHSCD--- 96
Cdd:cd10539  15 GFTVEADGFIKDLTIIAEYTGDVDYIRNRE----FDDNDSIMTLLLAGDPSKSLVICPDKRGNIARFIsginNHTKDgkk 90

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 12854173  97 -PNLQVFSVFIDNldtrLPRIALFSTRTINAGEELTFDY 134
Cdd:cd10539  91 kQNCKCVRYSING----EARVLLVATRDIAKGERLYYDY 125
SET_SMYD cd20071
SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing ...
 84-134 2.06e-07

SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing protein, and similar proteins; The family includes SET and MYND domain-containing proteins, SMYD1-SYMD5. SMYD1 (EC 2.1.1.43; also termed BOP) is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD2 (also termed HSKM-B, or lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. SMYD5 (also termed protein NN8-4AG, or retinoic acid-induced protein 15) functions as histone lysine methyltransferase that mediates H4K20me3 at heterochromatin regions.


Pssm-ID: 380997 [Multi-domain]  Cd Length: 122  Bit Score: 47.37  E-value: 2.06e-07
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 12854173  84 YGNVSHFvNHSCDPNlqVFSVFIDNldtrlPRIALFSTRTINAGEELTFDY 134
Cdd:cd20071  53 FPLASLL-NHSCDPN--AVVVFDGN-----GTLRVRALRDIKAGEELTISY 95
SET_SpSet7-like cd10540
SET domain found in Schizossacharomyces pombe Set7 and similar proteins; Schizosaccharomyces ...
 16-134 6.18e-06

SET domain found in Schizossacharomyces pombe Set7 and similar proteins; Schizosaccharomyces pombe Set7 is a novel histone-lysine N-methyltransferase. The family also includes a viral histone H3 lysine 27 methyltransferase from Paramecium bursaria Chlorella virus 1 (PBCV-1).


Pssm-ID: 380938  Cd Length: 112  Bit Score: 43.01  E-value: 6.18e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12854173  16 IFRTSNGCGWGVKTLVKIKRmsfvmeyvGEVItsEEAE----RRGQFYDNKGiTYLFDLDYE-SDEFTVDAARYGnvSHF 90
Cdd:cd10540   3 EVKPSTLKGRGVFATRPIKK--------GEVI--EEAPvivlPKEEYQHLCK-TVLDHYVFSwGDGCLALALGYG--SMF 69

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 12854173  91 vNHSCDPNLQVfsvfidNLDTRLPRIALFSTRTINAGEELTFDY 134
Cdd:cd10540  70 -NHSYTPNAEY------EIDFENQTIVFYALRDIEAGEELTINY 106
SET_SMYD4 cd10536
SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing ...
 90-134 1.31e-05

SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing protein 4 (SMYD4) and similar proteins; SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. In zebrafish, SMYD4 is ubiquitously expressed in early embryos and becomes enriched in the developing heart; mutants show a strong defect in cardiomyocyte proliferation, which lead to a severe cardiac malformation.


Pssm-ID: 380934 [Multi-domain]  Cd Length: 218  Bit Score: 43.83  E-value: 1.31e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 12854173  90 FVNHSCDPNlqVFSVFIDNLdtrlprIALFSTRTINAGEELTFDY 134
Cdd:cd10536 153 LLNHSCDPN--TIRSFYGNT------IVVRATRPIKKGEEITICY 189
SET_Suv4-20-like cd10524
SET domain (including post-SET domain) found in Drosophila melanogaster suppressor of ...
 90-168 4.04e-04

SET domain (including post-SET domain) found in Drosophila melanogaster suppressor of variegation 4-20 (Suv4-20) and similar proteins; Suv4-20 (also termed Su(var)4-20) is a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-20' of histone H4. It acts as a dominant suppressor of position-effect variegation. The family also includes Suv4-20 homologs, lysine N-methyltransferase 5B (KMT5B) and lysine N-methyltransferase 5C (KMT5C). Both KMT5B (also termed lysine-specific methyltransferase 5B, or suppressor of variegation 4-20 homolog 1, or Su(var)4-20 homolog 1, or Suv4-20h1) and KMT5C (also termed lysine-specific methyltransferase 5C, or suppressor of variegation 4-20 homolog 2, or Su(var)4-20 homolog 2, or Suv4-20h2) are histone methyltransferases that specifically trimethylate 'Lys-20' of histone H4 (H4K20me3). They play central roles in the establishment of constitutive heterochromatin in pericentric heterochromatin regions.


Pssm-ID: 380922 [Multi-domain]  Cd Length: 141  Bit Score: 38.80  E-value: 4.04e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 12854173  90 FVNHSCDPNLQVFSvfidnldTRLPRIALFSTRTINAGEELTFDYQMKGSGEASSDsidhspakkrvrtqCKCgaETCR 168
Cdd:cd10524  79 FINHDCRPNCKFVP-------TGKSTACVKVLRDIEPGEEITVYYGDNYFGENNEE--------------CEC--ETCE 134
SET_SMYD3 cd19203
SET domain (including post-SET domain) found in SET and MYND domain-containing protein 3 ...
 84-134 4.47e-03

SET domain (including post-SET domain) found in SET and MYND domain-containing protein 3 (SMYD3) and similar proteins; SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. It is overexpressed in colorectal, breast, prostate, and hepatocellular tumors, and has been implicated as an oncogene in human malignancies. Methylation of MEKK2 by SMYD3 is important for regulation of the MEK/ERK pathway, suggesting the possibility of selectively targeting SMYD3 in RAS-driven cancers.


Pssm-ID: 380980 [Multi-domain]  Cd Length: 210  Bit Score: 36.19  E-value: 4.47e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 12854173  84 YGNVSHFvNHSCDPNlqVFSVFidnldtRLPRIALFSTRTINAGEELTFDY 134
Cdd:cd19203 140 YPSASLL-NHSCDPN--CVIVF------NGPHLLLRAIREIEVGEELTISY 181
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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