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Conserved domains on  [gi|1304835152|gb|AUD52851|]
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valosin containing protein (p97)/p47 complex interacting protein 1, partial [Pseudis paradoxa]

Protein Classification

OTU domain-containing protein( domain architecture ID 1904167)

OTU (ovarian tumor) domain-containing protein may function as a deubiquitinase (DUBs)/ubiquitin thiolesterase that catalyzes the thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin, or may be inactive

EC:  3.4.19.12
PubMed:  10664582|23827681

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
OTU super family cl45892
OTU (ovarian tumor) domain family; The OTU family of cysteine proteases use a conserved ...
 1-141 1.69e-112

OTU (ovarian tumor) domain family; The OTU family of cysteine proteases use a conserved cysteine and histidine, and in most cases an aspartate, as the catalytic triad. OTU domains typically function as deubiquitinases (DUBs)/ubiquitin thiolesterases (EC 3.4.19.12) that catalyze the thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin, a small regulatory protein that can be conjugated to a large range of target proteins. Protein ubiquitination is a post-translational modification of mostly Lys residues that regulates many cellular processes, including protein degradation, intracellular trafficking, cell signaling, autophagy, transcription, translation, and the DNA damage response. These DUBs may play important regulatory roles at the level of protein turnover by preventing degradation.


The actual alignment was detected with superfamily member cd22769:

Pssm-ID: 459237  Cd Length: 197  Bit Score: 326.56  E-value: 1.69e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304835152   1 LVHAVSRALVGRELFWHALRENLKKHLKENLDRYKALFHDFIDVAEWEDIINECDPGFVPPEGVPLGLRNIHIFGLANVL 80
Cdd:cd22769    57 LVHAVSRALVGRELFWHALRENLKQHFKENLDQYKALFQDFIDDSEWPDIIAECDPDFVPPEGEPLGLRNIHIFGLANVL 136

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1304835152  81 HRPIILLDSLSGMRSSGDYSATFLPGLIPVENCKGKDGQLNKPICIAWSSSGRNHYIPLVG 141
Cdd:cd22769   137 KRPIILLDSLSGMQSSGDYSAIFLPGLVPPEKCRGKDGLLNKPICIAWSSSGRNHFIPLVG 197
 
Name Accession Description Interval E-value
OTU_VCIP135 cd22769
OTU (ovarian tumor) domain of deubiquitinating protein VCIP135; Deubiquitinating protein ...
 1-141 1.69e-112

OTU (ovarian tumor) domain of deubiquitinating protein VCIP135; Deubiquitinating protein VCIP135 is also called valosin-containing protein p97/p47 complex-interacting protein 1, valosin-containing protein p97/p47 complex-interacting protein p135, or VCP/p47 complex-interacting 135-kDa protein. It is a deubiquitinase (DUB)/ubiquitin thioesterase (EC 3.4.19.12) that hydrolyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitin chains. It is necessary for VCP-mediated reassembly of Golgi stacks after mitosis, and may play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER). VCIP135 controls Golgi membrane dynamics in the cell cycle and is required for Golgi and ER assembly. It belongs to the OTU family of cysteine proteases that use a conserved cysteine and histidine, and in most cases an aspartate, as the catalytic triad. Not all members of this subfamily contain the active site. It is closely related to proteins classified as family C64 cysteine protease by MEROPS, such as TNFAIP3, ZRANB1, and OTUD7A/B.


Pssm-ID: 438606  Cd Length: 197  Bit Score: 326.56  E-value: 1.69e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304835152   1 LVHAVSRALVGRELFWHALRENLKKHLKENLDRYKALFHDFIDVAEWEDIINECDPGFVPPEGVPLGLRNIHIFGLANVL 80
Cdd:cd22769    57 LVHAVSRALVGRELFWHALRENLKQHFKENLDQYKALFQDFIDDSEWPDIIAECDPDFVPPEGEPLGLRNIHIFGLANVL 136

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1304835152  81 HRPIILLDSLSGMRSSGDYSATFLPGLIPVENCKGKDGQLNKPICIAWSSSGRNHYIPLVG 141
Cdd:cd22769   137 KRPIILLDSLSGMQSSGDYSAIFLPGLVPPEKCRGKDGLLNKPICIAWSSSGRNHFIPLVG 197
OTU pfam02338
OTU-like cysteine protease; This family is comprised of a group of predicted cysteine ...
 1-136 1.66e-05

OTU-like cysteine protease; This family is comprised of a group of predicted cysteine proteases, homologous to the Ovarian Tumour (OTU) gene in Drosophila. Members include proteins from eukaryotes, viruses and pathogenic bacterium. The conserved cysteine and histidine, and possibly the aspartate, represent the catalytic residues in this putative group of proteases.


Pssm-ID: 426728 [Multi-domain]  Cd Length: 127  Bit Score: 43.98  E-value: 1.66e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304835152   1 LVHAVSRALVGR-ELFWHALRENLKKHLKENLDRYKALFHDFIDVAEWEDIINECDPGFVPPEgvplglrnIHIFGLANV 79
Cdd:pfam02338   7 LYRSISHQLWGVhDVLRKMLVQELRETLAEYMREHKEEFEPFLEDDETGDIIEIEQTGAWGGE--------IEIFALAHI 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304835152  80 LHRPIILLDSLSGMrssgdysatfLPGLIPVENcKGKDGQLNKPICIAWSS---SGRNHY 136
Cdd:pfam02338  79 LRRPIIVYKSEGGE----------ELGGLKEYG-IYLPLGWDPSLCLVYPRhlyYLGGHY 127
 
Name Accession Description Interval E-value
OTU_VCIP135 cd22769
OTU (ovarian tumor) domain of deubiquitinating protein VCIP135; Deubiquitinating protein ...
 1-141 1.69e-112

OTU (ovarian tumor) domain of deubiquitinating protein VCIP135; Deubiquitinating protein VCIP135 is also called valosin-containing protein p97/p47 complex-interacting protein 1, valosin-containing protein p97/p47 complex-interacting protein p135, or VCP/p47 complex-interacting 135-kDa protein. It is a deubiquitinase (DUB)/ubiquitin thioesterase (EC 3.4.19.12) that hydrolyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitin chains. It is necessary for VCP-mediated reassembly of Golgi stacks after mitosis, and may play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER). VCIP135 controls Golgi membrane dynamics in the cell cycle and is required for Golgi and ER assembly. It belongs to the OTU family of cysteine proteases that use a conserved cysteine and histidine, and in most cases an aspartate, as the catalytic triad. Not all members of this subfamily contain the active site. It is closely related to proteins classified as family C64 cysteine protease by MEROPS, such as TNFAIP3, ZRANB1, and OTUD7A/B.


Pssm-ID: 438606  Cd Length: 197  Bit Score: 326.56  E-value: 1.69e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304835152   1 LVHAVSRALVGRELFWHALRENLKKHLKENLDRYKALFHDFIDVAEWEDIINECDPGFVPPEGVPLGLRNIHIFGLANVL 80
Cdd:cd22769    57 LVHAVSRALVGRELFWHALRENLKQHFKENLDQYKALFQDFIDDSEWPDIIAECDPDFVPPEGEPLGLRNIHIFGLANVL 136

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1304835152  81 HRPIILLDSLSGMRSSGDYSATFLPGLIPVENCKGKDGQLNKPICIAWSSSGRNHYIPLVG 141
Cdd:cd22769   137 KRPIILLDSLSGMQSSGDYSAIFLPGLVPPEKCRGKDGLLNKPICIAWSSSGRNHFIPLVG 197
OTU_C64 cd22750
OTU (ovarian tumor) domain of family C64 cysteine proteases; This group includes proteins ...
 1-140 4.03e-31

OTU (ovarian tumor) domain of family C64 cysteine proteases; This group includes proteins classified as family C64 cysteine protease by MEROPS, such as tumor necrosis factor (TNF) alpha-induced protein 3 (TNFAIP3), ZRANB1, OTU domain-containing protein 7A (OTUD7A), and OTUD7B. It also includes VCIP135. These proteins are deubiquitinases (DUBs)/ubiquitin thioesterases (EC 3.4.19.12) that mediates the deubiquitination of protein substrates. TNFAIP3 also contains ubiquitin ligase activity. It antagonizes IKK [IkappaB (inhibitor of kappaB) kinase] activation by modulating Lys63-linked polyubiquitination of cytokine-receptor-associated factors including TRAF2/6 (tumour-necrosis-factor-receptor-associated factor 2/6) and RIP1 (receptor-interacting protein 1). ZRANB1 binds, deubiquitinates, and stabilizes EZH2, which is the catalytic component of the Polycomb repressive complex 2 (PRC2) that silences gene transcription by methylating histone H3 at lysine 27 and is mutated or highly expressed in many types of cancer, including lymphoma, melanoma, prostate cancer, ovarian cancer, and breast cancer. OTUD7A has been identified as a critical gene for brain function, while OTUD7B functions as a negative regulator of the non-canonical NF-kappaB pathway by mediating the deubiquitination of TRAF3, an inhibitor of the NF-kappaB pathway, resulting in preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappaB. VCIP135 controls Golgi membrane dynamics in the cell cycle and is required for Golgi and ER assembly. This group belongs to the OTU family of cysteine proteases that use a conserved cysteine and histidine, and in most cases an aspartate, as the catalytic triad.


Pssm-ID: 438587  Cd Length: 185  Bit Score: 116.67  E-value: 4.03e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304835152   1 LVHAVSRALVGRELFWHALRENLKKHLKENLD-----RYKALFHDF-----------IDVAEWEDIINECDPGFVPpEGV 64
Cdd:cd22750    34 LLHAVSLALWGVEDRDLLLRSALHETLQNDQErrfraRWRRQQLKSgqelglsldeeALQAEWEEILKAAETPTVP-AGP 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304835152  65 PLGLRNIHIFGLANVLHRPIILLDSLSGMRSSG------DYSATFLPGLIPVENCkgkdgqLNKPICIAWSSsgrNHYIP 138
Cdd:cd22750   113 GSYLEEIHIFVLANVLRRPIIVLADDSARSLEGsalqdnGMSGIYLPLLWPPSEC------SRSPLALGYSN---GHFSP 183


                  ..
gi 1304835152 139 LV 140
Cdd:cd22750   184 LV 185
OTU cd22744
OTU (ovarian tumor) domain family; The OTU family of cysteine proteases use a conserved ...
 3-139 2.97e-08

OTU (ovarian tumor) domain family; The OTU family of cysteine proteases use a conserved cysteine and histidine, and in most cases an aspartate, as the catalytic triad. OTU domains typically function as deubiquitinases (DUBs)/ubiquitin thiolesterases (EC 3.4.19.12) that catalyze the thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin, a small regulatory protein that can be conjugated to a large range of target proteins. Protein ubiquitination is a post-translational modification of mostly Lys residues that regulates many cellular processes, including protein degradation, intracellular trafficking, cell signaling, autophagy, transcription, translation, and the DNA damage response. These DUBs may play important regulatory roles at the level of protein turnover by preventing degradation.


Pssm-ID: 438581 [Multi-domain]  Cd Length: 128  Bit Score: 51.67  E-value: 2.97e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304835152   3 HAVSRALVGRELFWHALRENLKKHLKENLDRYKALFHDFIDVAE-WEDIINEcdpgfVPPEGVPLGlrNIHIFGLANVLH 81
Cdd:cd22744    14 RALAHALYGDQESHRELRQEVVDYLRENPDLYEPAELADEDDGEdFDEYLQR-----MRKPGTWGG--ELELQALANALN 86

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1304835152  82 RPIILLDSLSGMRssgdysatflpgliPVENCKGKDGQLNKPICIAWssSGRNHYIPL 139
Cdd:cd22744    87 VPIVVYSEDGGFL--------------PVSVFGPGPGPSGRPIHLLY--TGGNHYDAL 128
OTU_TNFAIP3 cd22766
OTU (ovarian tumor) domain of tumor necrosis factor alpha induced protein 3; Tumor necrosis ...
 1-140 1.20e-07

OTU (ovarian tumor) domain of tumor necrosis factor alpha induced protein 3; Tumor necrosis factor (TNF) alpha-induced protein 3 (TNFAIP3) is also called OTU domain-containing protein 7C (OTUD7C), DNA-binding protein A20, or zinc finger protein A20. It is a ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase (DUB)/ubiquitin thioesterase (EC 3.4.19.12) activities. It antagonizes IKK [IkappaB (inhibitor of kappaB) kinase] activation by modulating Lys63-linked polyubiquitination of cytokine-receptor-associated factors including TRAF2/6 (tumour-necrosis-factor-receptor-associated factor 2/6) and RIP1 (receptor-interacting protein 1). It can also inhibit IKK through a non-catalytic mechanism which involves polyubiquitin. In vitro, TNFAIP3 is able to deubiquitinate 'Lys-11'-, 'Lys-48'- and 'Lys-63' polyubiquitin chains. TNFAIP3 contains several A20-type zinc fingers that mediate the ubiquitin ligase activity and an OTU (ovarian tumor) domain that contains the DUB activity. It belongs to the OTU family of cysteine proteases that use a conserved cysteine, histidine, and an aspartate, as the catalytic triad. It is classified as a family C64 cysteine protease by MEROPS.


Pssm-ID: 438603  Cd Length: 220  Bit Score: 51.88  E-value: 1.20e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304835152   1 LVHAVSRALVG--------RELFWHALRENLKKHLKENLDRYKALFHDFIDV----------AEWEDIINECDPGFVPPE 62
Cdd:cd22766    64 LLHAVSLYMWGvqdtdlvlRKALYEALVETDTRNFKLRWQRERLKSQEFVGTglrydtreweEEWDNVVKMASPESKPAA 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304835152  63 GVPL--GLRNIHIFGLANVLHRPIILL--DSLSGMRSSG----DYSATFLPGLIPVENCkgkdgqLNKPICIAWSSsgrN 134
Cdd:cd22766   144 GGLPynSLEEIHIFVLANILRRPIIVIadDMLRSLEGSSlaplNFGGIYLPLHWPPQEC------YKYPIVLGYDS---Q 214


                  ....*.
gi 1304835152 135 HYIPLV 140
Cdd:cd22766   215 HFTPLV 220
OTU pfam02338
OTU-like cysteine protease; This family is comprised of a group of predicted cysteine ...
 1-136 1.66e-05

OTU-like cysteine protease; This family is comprised of a group of predicted cysteine proteases, homologous to the Ovarian Tumour (OTU) gene in Drosophila. Members include proteins from eukaryotes, viruses and pathogenic bacterium. The conserved cysteine and histidine, and possibly the aspartate, represent the catalytic residues in this putative group of proteases.


Pssm-ID: 426728 [Multi-domain]  Cd Length: 127  Bit Score: 43.98  E-value: 1.66e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304835152   1 LVHAVSRALVGR-ELFWHALRENLKKHLKENLDRYKALFHDFIDVAEWEDIINECDPGFVPPEgvplglrnIHIFGLANV 79
Cdd:pfam02338   7 LYRSISHQLWGVhDVLRKMLVQELRETLAEYMREHKEEFEPFLEDDETGDIIEIEQTGAWGGE--------IEIFALAHI 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304835152  80 LHRPIILLDSLSGMrssgdysatfLPGLIPVENcKGKDGQLNKPICIAWSS---SGRNHY 136
Cdd:pfam02338  79 LRRPIIVYKSEGGE----------ELGGLKEYG-IYLPLGWDPSLCLVYPRhlyYLGGHY 127
OTU_VRTN cd22791
OTU (ovarian tumor) domain of vertnin and similar proteins; Vertnin (VRTN) is an OTU ...
 1-140 7.48e-05

OTU (ovarian tumor) domain of vertnin and similar proteins; Vertnin (VRTN) is an OTU domain-containing protein that is required for the development of thoracic vertebrae in mammals. OTU domains typically function as deubiquitinases (DUBs)/ubiquitin thiolesterases (EC 3.4.19.12) that catalyze the thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin, a small regulatory protein that can be conjugated to a large range of target proteins. Protein ubiquitination is a post-translational modification of mostly Lys residues that regulates many cellular processes, including protein degradation, intracellular trafficking, cell signaling, autophagy, transcription, translation, and the DNA damage response. These DUBs may play important regulatory roles at the level of protein turnover by preventing degradation. Vertnin and some subfamily members do not possess the conserved catalytic residues and may not have DUB activity. VRTN gene is associated with variations in vertebral number.


Pssm-ID: 438612  Cd Length: 137  Bit Score: 42.21  E-value: 7.48e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304835152   1 LVHAVSRALVGRELFWHALRENLKKHLKENLDRYKALFHdfidvaewEDIINECDPG-FVPPegvplglrnIHIFGLANV 79
Cdd:cd22791    13 LFRAASLLLFGDESLHLELRLRTVLELVLNSEFYEAIYE--------AEIKATCKPGsYSGI---------WHIYALSSV 75

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1304835152  80 LHRPIILL-DSLSGMRSSGDYSATFLPglipvenCKGKDGqlNKPICIAWSSSGR---------NHYIPLV 140
Cdd:cd22791    76 LQRPIFSVyPEVGNQKIRPLLNRTIRP-------RKTSKS--IETIHIMWTSTSLknnssnwkpNHFVPLL 137
OTU_OTUD7B cd22772
OTU (ovarian tumor) domain of OTU domain-containing protein 7B; OTU domain-containing protein ...
 3-140 5.04e-04

OTU (ovarian tumor) domain of OTU domain-containing protein 7B; OTU domain-containing protein 7B (OTUD7B) is also called cellular zinc finger anti-NF-kappa-B protein, zinc finger A20 domain-containing protein 1, or zinc finger protein Cezanne. It is a deubiquitinase (DUB)/ubiquitin thioesterase (EC 3.4.19.12) that specifically targets Lys11-linked polyubiquitin. It functions as a negative regulator of the non-canonical NF-kappaB pathway by mediating the deubiquitination of TRAF3, an inhibitor of the NF-kappaB pathway, resulting in preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappaB. OTUD7B also deubiquitinates ZAP70, and thus, regulates T cell receptor (TCR) signaling. It belongs to the OTU family of cysteine proteases that use a conserved cysteine, histidine, and an aspartate, as the catalytic triad. It is classified as a family C64 cysteine protease by MEROPS.


Pssm-ID: 438609  Cd Length: 207  Bit Score: 40.79  E-value: 5.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304835152   3 HAVSRALVGRELFWHALRENLKKHLKENLDRYKALFHDFIDVAEWEDII------NECDPGFVPPEGVPLGLRNIHIFGL 76
Cdd:cd22772    66 KGVEKEALKRRWRWQQTQQNKESGLVYTEDEWQKEWNELIKLASSEPRMhygtngANCGGVESSEEPVYESLEEFHVFVL 145

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1304835152  77 ANVLHRPIILL-DSLsgMRSSGD-------YSATFLPGLIPVENCKgkdgqlNKPICIAWSSSgrnHYIPLV 140
Cdd:cd22772   146 AHVLRRPIVVVaDTM--LRDSGGeafapipFGGIYLPLEVPASKCH------RSPLVLAYDQA---HFSALV 206
OTU_OTUD7 cd22768
OTU (ovarian tumor) domain of OTU domain-containing proteins 7A, 7B, and similar proteins; ...
 46-140 1.26e-03

OTU (ovarian tumor) domain of OTU domain-containing proteins 7A, 7B, and similar proteins; This subfamily consists of OTU domain-containing protein 7A (OTUD7A), OTUD7B, and similar proteins. OTUD7A and OTUD7B are deubiquitinases (DUBs)/ubiquitin thioesterases (EC 3.4.19.12) that specifically target Lys11-linked polyubiquitin. OTUD7A, also called zinc finger protein Cezanne 2, has been identified as a critical gene for brain function. It localizes to dendritic and spine compartments in cortical neurons, and its reduced levels contributed to dendritic spine and dendrite outgrowth deficits. OTUD7B, also called zinc finger protein Cezanne, functions as a negative regulator of the non-canonical NF-kappaB pathway by mediating the deubiquitination of TRAF3, an inhibitor of the NF-kappaB pathway, resulting in preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappaB. OTUD7 proteins belongs to the OTU family of cysteine proteases that use a conserved cysteine, histidine, and an aspartate, as the catalytic triad. They are classified as family C64 cysteine proteases by MEROPS.


Pssm-ID: 438605  Cd Length: 208  Bit Score: 39.59  E-value: 1.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304835152  46 EWEDIIN--------ECDPGFVPPEGVPLG---------LRNIHIFGLANVLHRPII------LLDslsgmrSSGDYSA- 101
Cdd:cd22768    99 EWKSLLKlasteprsQPSPSSGSELEEVIEnssdptyesLEEIHVFVLAHVLRRPIIvvadtmLRD------SNGEPLAp 172

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1304835152 102 -TF----LPGLIPVENCkgkdgqLNKPICIAWSSSgrnHYIPLV 140
Cdd:cd22768   173 iPFggiyLPLECPPSEC------HRSPLVLAYDAA---HFSALV 207
OTU_232R-like cd22758
OTU (ovarian tumor) domain of Invertebrate iridescent virus putative ubiquitin thioesterase ...
 3-94 4.18e-03

OTU (ovarian tumor) domain of Invertebrate iridescent virus putative ubiquitin thioesterase 232R and similar proteins; This subfamily contains putative ubiquitin thioesterases 232R from Invertebrate iridescent virus and L96 from Tipula iridescent virus (TIV), Dictyostelium discoideum OTU domain-containing protein DDB_G0284757, and similar proteins. L96 may be involved in TIV genomic DNA packaging in a manner related to the Gag polyproteins of the mammalian viruses. Proteins in this subfamily contain an OTU domain. OTU domains typically function as deubiquitinases (DUBs)/ubiquitin thiolesterases (EC 3.4.19.12) that catalyze the thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin, a small regulatory protein that can be conjugated to a large range of target proteins. Protein ubiquitination is a post-translational modification of mostly Lys residues that regulates many cellular processes, including protein degradation, intracellular trafficking, cell signaling, autophagy, transcription, translation, and the DNA damage response. These DUBs may play important regulatory roles at the level of protein turnover by preventing degradation. They belong to the OTU family of cysteine proteases that use a conserved cysteine, histidine, and an aspartate, as the catalytic triad.


Pssm-ID: 438595 [Multi-domain]  Cd Length: 135  Bit Score: 37.25  E-value: 4.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304835152   3 HAVSRALVGRELFWHA--LRENLKKHLKENLDRYK-ALFHDFIDVAEWEDIINE-------CDpgfvppegvplglrNIH 72
Cdd:cd22758    20 HAVSDQLYGNGIEHSHkeLRQQAVNYLRENPELYDgFFLSEFDEEESWEEYLNRmskdgtwGD--------------HII 85

                          90       100
                  ....*....|....*....|..
gi 1304835152  73 IFGLANVLHRPIILLDSLSGMR 94
Cdd:cd22758    86 LQAAANLFNVRIVIISSDGSDE 107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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