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Conserved domains on  [gi|13095598|ref|NP_076513|]
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thymidine kinase [Bovine gammaherpesvirus 4]

Protein Classification

PHA03132 family protein( domain architecture ID 11476168)

PHA03132 family protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA03132 PHA03132
thymidine kinase; Provisional
 6-445 0e+00

thymidine kinase; Provisional


:

Pssm-ID: 222997 [Multi-domain]  Cd Length: 580  Bit Score: 598.29  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13095598    6 IPGKCEDCFTCESYSFNFESDSGFSCEDVAQYrdlsqyrDLPQLNTCHERHQQDIYERDNVYE------------ATFFT 73
Cdd:PHA03132   1 GPGKPRGQPGRWNYDSSDESPEGSRDENFDAE-------RDDFLTPLGSTSEATSEDDDDLYPpretgsgggvatSTIYT 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13095598   74 PPRE---------------------------------------------------------------------------- 77
Cdd:PHA03132  74 VPRPprgpeqtldkpdslpasrelppgptpvppggfrgassprlgadstsprflyqvnfpvilapigesnssseelseee 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13095598   78 ----------------------------------------------------KLPSITALSESFTNLSFTDGT-TTSPDW 104
Cdd:PHA03132 154 ehsrpppseslkvknggkvypkgfskhkthkrsefsgltkkaarkrkgsfvfKPSQLKELSGSLKNLLHLDDSaETDPAT 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13095598  105 PAKPAPAHLLYPRPPTGYTD---AYFIFFEGVMGVGKTTLLKTLARNDMNNVIIFEEAMNYWKTVFSDCHKLIYDVMKMG 181
Cdd:PHA03132 234 RQVPVPVHVLYPPLLTEYVPykpACFLFLEGVMGVGKTTLLNHMRGILGDNVLVFPEPMRYWTEVYSNCLKEIYKLVKPG 313

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13095598  182 KHGSFSVSSKLLACQMKFLTPLKSLGRVTAMFSGKEMQRSPgRSDVSHWVMFDRHALSACLVFPLVMLKSGMLSFEHFIS 261
Cdd:PHA03132 314 KHGKTSTSAKLLACQMKFATPFRALATRTRRLVQPESVRRP-VAPLDNWVLFDRHLLSATVVFPLMHLRNGMLSFSHFIQ 392

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13095598  262 LVSTFRANEGDIIVLIALDHGEAIRRIKTRKRPEEETISLTYVIRLHWCFVAVYNTWRLLQYFTAREATEVCLDIKTING 341
Cdd:PHA03132 393 LLSTFRAHEGDVIVLLKLNSEENLRRVKKRGRKEEKGINLTYLKELNWAYHAVYCAWLLLQYFTPEDIVQVCLGTTTITT 472

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13095598  342 LCLSKDICYQKCLEFQTLWNESLLAILRDIIFPYKSDCTILELCLNVCTQIQKLKFVVSDATKYIGDVRGLWEDISTQIL 421
Cdd:PHA03132 473 VCHSSGTVAIKHLTAEKLWKNSIFNTLRDVIQPFRHDCTLLEVCLTFCKELSKLQFVVVDASEFQDDVPGLWTEIYTQIL 552

                        570       580
                 ....*....|....*....|....
gi 13095598  422 QSRVIKTRPVDWANLKSLAKEFCG 445
Cdd:PHA03132 553 KNPAIKTRFVDWAALEKLISTFNS 576
 
Name Accession Description Interval E-value
PHA03132 PHA03132
thymidine kinase; Provisional
 6-445 0e+00

thymidine kinase; Provisional


Pssm-ID: 222997 [Multi-domain]  Cd Length: 580  Bit Score: 598.29  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13095598    6 IPGKCEDCFTCESYSFNFESDSGFSCEDVAQYrdlsqyrDLPQLNTCHERHQQDIYERDNVYE------------ATFFT 73
Cdd:PHA03132   1 GPGKPRGQPGRWNYDSSDESPEGSRDENFDAE-------RDDFLTPLGSTSEATSEDDDDLYPpretgsgggvatSTIYT 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13095598   74 PPRE---------------------------------------------------------------------------- 77
Cdd:PHA03132  74 VPRPprgpeqtldkpdslpasrelppgptpvppggfrgassprlgadstsprflyqvnfpvilapigesnssseelseee 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13095598   78 ----------------------------------------------------KLPSITALSESFTNLSFTDGT-TTSPDW 104
Cdd:PHA03132 154 ehsrpppseslkvknggkvypkgfskhkthkrsefsgltkkaarkrkgsfvfKPSQLKELSGSLKNLLHLDDSaETDPAT 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13095598  105 PAKPAPAHLLYPRPPTGYTD---AYFIFFEGVMGVGKTTLLKTLARNDMNNVIIFEEAMNYWKTVFSDCHKLIYDVMKMG 181
Cdd:PHA03132 234 RQVPVPVHVLYPPLLTEYVPykpACFLFLEGVMGVGKTTLLNHMRGILGDNVLVFPEPMRYWTEVYSNCLKEIYKLVKPG 313

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13095598  182 KHGSFSVSSKLLACQMKFLTPLKSLGRVTAMFSGKEMQRSPgRSDVSHWVMFDRHALSACLVFPLVMLKSGMLSFEHFIS 261
Cdd:PHA03132 314 KHGKTSTSAKLLACQMKFATPFRALATRTRRLVQPESVRRP-VAPLDNWVLFDRHLLSATVVFPLMHLRNGMLSFSHFIQ 392

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13095598  262 LVSTFRANEGDIIVLIALDHGEAIRRIKTRKRPEEETISLTYVIRLHWCFVAVYNTWRLLQYFTAREATEVCLDIKTING 341
Cdd:PHA03132 393 LLSTFRAHEGDVIVLLKLNSEENLRRVKKRGRKEEKGINLTYLKELNWAYHAVYCAWLLLQYFTPEDIVQVCLGTTTITT 472

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13095598  342 LCLSKDICYQKCLEFQTLWNESLLAILRDIIFPYKSDCTILELCLNVCTQIQKLKFVVSDATKYIGDVRGLWEDISTQIL 421
Cdd:PHA03132 473 VCHSSGTVAIKHLTAEKLWKNSIFNTLRDVIQPFRHDCTLLEVCLTFCKELSKLQFVVVDASEFQDDVPGLWTEIYTQIL 552

                        570       580
                 ....*....|....*....|....
gi 13095598  422 QSRVIKTRPVDWANLKSLAKEFCG 445
Cdd:PHA03132 553 KNPAIKTRFVDWAALEKLISTFNS 576
Herpes_TK pfam00693
Thymidine kinase from herpesvirus;
132-322 3.38e-20

Thymidine kinase from herpesvirus;


Pssm-ID: 395563  Cd Length: 280  Bit Score: 90.25  E-value: 3.38e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13095598   132 GVMGVGKTTLLKTLARNDM--NNVIIFEEAMNYWKTVF-SDCHKLIYDVMKMGKHGSFSV---SSKLLACQMKFLTPLKS 205
Cdd:pfam00693   1 GAHGIGKTTTLRQILKHLAyrDRILYVPEPMTYWRVLFaSDAITNIYTTQHRRDRGEISLgeaSRVVTSAQSTFSAPYAI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13095598   206 L-GRVTAMFSGKEMQRSPGRSDVSHWVMFDRHALSACLVFPLVMLKSGMLSFEHFISLVSTFRAN-EGDIIVLIALDHGE 283
Cdd:pfam00693  81 MhAVLSPHIGGEAEATSAHAGEPALILIFDRHPIASTLCFPAARYLTGDMSPQALIALVATLPPEpPGTNLVIGDLSEEE 160

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 13095598   284 AIRRIKTRKRPeEETISLTYVIRLHWCFVAVYNTWRLLQ 322
Cdd:pfam00693 161 HASRLSKRQRP-GERVDLAMLRALRNVYILLANTVRYLQ 198
dNK cd01673
Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to ...
 127-318 1.18e-07

Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1.113), adenosine (EC 2.7.1.76), and thymidine (EC 2.7.1.21) kinases. They are key enzymes in the salvage of deoxyribonucleosides originating from extra- or intracellular breakdown of DNA.


Pssm-ID: 238836  Cd Length: 193  Bit Score: 51.84  E-value: 1.18e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13095598 127 FIFFEGVMGVGKTTLLKTLArnDMNNVIIFEEAmNYWKTVFSDCHKLIYDvmKMGKHgSFSVsskllacQMKFLtplksL 206
Cdd:cd01673   1 VIVVEGNIGAGKSTLAKELA--EHLGYEVVPEP-VEPDVEGNPFLEKFYE--DPKRW-AFPF-------QLYFL-----L 62

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13095598 207 GRVTAMfsgKEMQRSPGRSDVshwVMFDRHALSACLVFpLVMLKSGMLSF-------EHFISLVSTFRANegDIIVLIAL 279
Cdd:cd01673  63 SRLKQY---KDALEHLSTGQG---VILERSIFSDRVFA-EANLKEGGIMKteydlynELFDNLIPELLPP--DLVIYLDA 133

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 13095598 280 DHGEAIRRIKTRKRPEEETISLTYVIRLHwcfvAVYNTW 318
Cdd:cd01673 134 SPETCLKRIKKRGRPEEQGIPLDYLEDLH----EAYEKW 168
 
Name Accession Description Interval E-value
PHA03132 PHA03132
thymidine kinase; Provisional
 6-445 0e+00

thymidine kinase; Provisional


Pssm-ID: 222997 [Multi-domain]  Cd Length: 580  Bit Score: 598.29  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13095598    6 IPGKCEDCFTCESYSFNFESDSGFSCEDVAQYrdlsqyrDLPQLNTCHERHQQDIYERDNVYE------------ATFFT 73
Cdd:PHA03132   1 GPGKPRGQPGRWNYDSSDESPEGSRDENFDAE-------RDDFLTPLGSTSEATSEDDDDLYPpretgsgggvatSTIYT 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13095598   74 PPRE---------------------------------------------------------------------------- 77
Cdd:PHA03132  74 VPRPprgpeqtldkpdslpasrelppgptpvppggfrgassprlgadstsprflyqvnfpvilapigesnssseelseee 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13095598   78 ----------------------------------------------------KLPSITALSESFTNLSFTDGT-TTSPDW 104
Cdd:PHA03132 154 ehsrpppseslkvknggkvypkgfskhkthkrsefsgltkkaarkrkgsfvfKPSQLKELSGSLKNLLHLDDSaETDPAT 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13095598  105 PAKPAPAHLLYPRPPTGYTD---AYFIFFEGVMGVGKTTLLKTLARNDMNNVIIFEEAMNYWKTVFSDCHKLIYDVMKMG 181
Cdd:PHA03132 234 RQVPVPVHVLYPPLLTEYVPykpACFLFLEGVMGVGKTTLLNHMRGILGDNVLVFPEPMRYWTEVYSNCLKEIYKLVKPG 313

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13095598  182 KHGSFSVSSKLLACQMKFLTPLKSLGRVTAMFSGKEMQRSPgRSDVSHWVMFDRHALSACLVFPLVMLKSGMLSFEHFIS 261
Cdd:PHA03132 314 KHGKTSTSAKLLACQMKFATPFRALATRTRRLVQPESVRRP-VAPLDNWVLFDRHLLSATVVFPLMHLRNGMLSFSHFIQ 392

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13095598  262 LVSTFRANEGDIIVLIALDHGEAIRRIKTRKRPEEETISLTYVIRLHWCFVAVYNTWRLLQYFTAREATEVCLDIKTING 341
Cdd:PHA03132 393 LLSTFRAHEGDVIVLLKLNSEENLRRVKKRGRKEEKGINLTYLKELNWAYHAVYCAWLLLQYFTPEDIVQVCLGTTTITT 472

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13095598  342 LCLSKDICYQKCLEFQTLWNESLLAILRDIIFPYKSDCTILELCLNVCTQIQKLKFVVSDATKYIGDVRGLWEDISTQIL 421
Cdd:PHA03132 473 VCHSSGTVAIKHLTAEKLWKNSIFNTLRDVIQPFRHDCTLLEVCLTFCKELSKLQFVVVDASEFQDDVPGLWTEIYTQIL 552

                        570       580
                 ....*....|....*....|....
gi 13095598  422 QSRVIKTRPVDWANLKSLAKEFCG 445
Cdd:PHA03132 553 KNPAIKTRFVDWAALEKLISTFNS 576
PHA03134 PHA03134
thymidine kinase; Provisional
 128-321 1.70e-21

thymidine kinase; Provisional


Pssm-ID: 177537  Cd Length: 340  Bit Score: 94.87  E-value: 1.70e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13095598  128 IFFEGVMGVGKTTLLKTLARNDM--NNVIIFEEAMNYWKTVF-SDCHKLIYDVMKMGKHGSFSVSSKLLAC---QMKFLT 201
Cdd:PHA03134  16 IYLDGAYGIGKSTTGRVMASAASggGPTLYFPEPMAYWRTLFeTDVVSGIYDAQNRKQQGSLAAEDAAGITahyQARFAT 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13095598  202 PLKSL-GRVTAMFSGKEMQRSpGRSDVShwVMFDRHALSACLVFPLVMLKSGMLSFEHFISLVSTF-RANEGDIIVLIAL 279
Cdd:PHA03134  96 PYLILhDRLSTLFGPPSLARG-GRPDVT--LVFDRHPVASCVCFPLARYLLGDMSACALLALAATLpREPPGGNLVVTTL 172

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 13095598  280 DHGEAIRRIKTRKRPEEEtISLTYVIRLHWCFVAVYNTWRLL 321
Cdd:PHA03134 173 NPDEHLRRLRARARIGEQ-IDAKLIAALRNVYAMLVNTCAFL 213
PHA03136 PHA03136
thymidine kinase; Provisional
 128-322 3.21e-21

thymidine kinase; Provisional


Pssm-ID: 177538  Cd Length: 378  Bit Score: 94.77  E-value: 3.21e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13095598  128 IFFEGVMGVGKTTLLKTLAR--NDMNNVIIFEEAMNYWKTVF--SDCHKLIYDVMKMGKHGSFSVS-SKLLAC---QMKF 199
Cdd:PHA03136  39 LYLDGPFGTGKTTTAKLLMEmpDTLAARLYLAEPMAAWRNHFggADMIKEINEIQELKARGDIACRdAKAIAAaelQLQF 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13095598  200 LTPLKSLGRVTAMFSGKEMQRS-PGRSDVSHWVMFDRHALSACLVFPLVMLKSGMLSFEHFISLVSTF-RANEGDIIVLI 277
Cdd:PHA03136 119 AAPLRIFHHVASNLFGSERCYSaAARGPDDILFIIDRHPLAACLCFPAAQFLSGALEFGDLIALISGIpDEPHGGNIVIM 198

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 13095598  278 ALDHGEAIRRIKTRKRPeEETISLTYVIRLHWCFVAVYNTWRLLQ 322
Cdd:PHA03136 199 DLDECEHAERIIARGRP-GEAIDVRFLCALHNIYICFMNTITYAK 242
Herpes_TK pfam00693
Thymidine kinase from herpesvirus;
132-322 3.38e-20

Thymidine kinase from herpesvirus;


Pssm-ID: 395563  Cd Length: 280  Bit Score: 90.25  E-value: 3.38e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13095598   132 GVMGVGKTTLLKTLARNDM--NNVIIFEEAMNYWKTVF-SDCHKLIYDVMKMGKHGSFSV---SSKLLACQMKFLTPLKS 205
Cdd:pfam00693   1 GAHGIGKTTTLRQILKHLAyrDRILYVPEPMTYWRVLFaSDAITNIYTTQHRRDRGEISLgeaSRVVTSAQSTFSAPYAI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13095598   206 L-GRVTAMFSGKEMQRSPGRSDVSHWVMFDRHALSACLVFPLVMLKSGMLSFEHFISLVSTFRAN-EGDIIVLIALDHGE 283
Cdd:pfam00693  81 MhAVLSPHIGGEAEATSAHAGEPALILIFDRHPIASTLCFPAARYLTGDMSPQALIALVATLPPEpPGTNLVIGDLSEEE 160

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 13095598   284 AIRRIKTRKRPeEETISLTYVIRLHWCFVAVYNTWRLLQ 322
Cdd:pfam00693 161 HASRLSKRQRP-GERVDLAMLRALRNVYILLANTVRYLQ 198
PHA03135 PHA03135
thymidine kinase; Provisional
 128-298 1.77e-11

thymidine kinase; Provisional


Pssm-ID: 165407  Cd Length: 343  Bit Score: 65.34  E-value: 1.77e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13095598  128 IFFEGVMGVGKTTLLKTLARNDMNNVIIFE--EAMNYWKTVFSDCHKLIYDVMKMGKHGSFSV---SSKLLACQMKFLTP 202
Cdd:PHA03135  13 VYLDGPFGIGKTSMLNEMPDHSPDGVPVLKvfEPMKYWRCYFTDLVVAVNDTPERRRRGELSLfqsSMIVAALQAKFADP 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13095598  203 LKSLGRvtaMFSGKEMQRSPGRSDVSHWVMFDRHALSACLVFPLVMLKSGMLSFEHFISLVSTFRANEG--DIIVLIALD 280
Cdd:PHA03135  93 YLVFHE---RLSSKCHGKIGTRGNPSLILILDRHPVSATVCFPIARHLLGDCSLEMLISSIIRLPLEPPgcNLVITILPD 169

                        170
                 ....*....|....*...
gi 13095598  281 HGEAIRRIKTRKRPEEET 298
Cdd:PHA03135 170 EKEHVNRLSSRNRPGETT 187
dNK pfam01712
Deoxynucleoside kinase; This family consists of various deoxynucleoside kinases cytidine EC:2. ...
 128-308 4.76e-10

Deoxynucleoside kinase; This family consists of various deoxynucleoside kinases cytidine EC:2.7.1.74, guanosine EC:2.7.1.113, adenosine EC:2.7.1.76 and thymidine kinase EC:2.7.1.21 (which also phosphorylates deoxyuridine and deoxycytosine.) These enzymes catalyze the production of deoxynucleotide 5'-monophosphate from a deoxynucleoside. Using ATP and yielding ADP in the process.


Pssm-ID: 396326  Cd Length: 201  Bit Score: 58.87  E-value: 4.76e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13095598   128 IFFEGVMGVGKTTLLKTLARNdmNNVIIFEEAMNYWKTVFSDchkLIYDVMKmgkHGSFSVSSKLLACQMKfltplkslg 207
Cdd:pfam01712   1 ISIEGNIGAGKSTLTKILSKR--LGFKVFEEPVDRWTNPYLD---KFYKDPS---RWSFALQTYFLNSRFK--------- 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13095598   208 rvtamfsgkeMQRSPgrSDVSHWVMFDRHALSACLVFPLVMLKSGMLS---FEHFISLVS--TFRANEGDIIVLIALDHG 282
Cdd:pfam01712  64 ----------QQLEA--FFTGQVVILERSIYSDRYIFAKMLYDKGTMSdeeYKTYKDLYDnmLLEFPKPDLIIYLKTSPE 131

                         170       180
                  ....*....|....*....|....*.
gi 13095598   283 EAIRRIKTRKRPEEETISLTYVIRLH 308
Cdd:pfam01712 132 TCLERIKKRGRTEEQNISLDYLERLH 157
PHA03133 PHA03133
thymidine kinase; Provisional
 96-322 1.28e-09

thymidine kinase; Provisional


Pssm-ID: 165405  Cd Length: 368  Bit Score: 59.55  E-value: 1.28e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13095598   96 DGTTTSPDWPAKPAPahlLYPRPPTGYTDAYFIFFEGVMGVGKTT----LLKTLARNDmnNVIIFEEAMNYWKTV-FSDC 170
Cdd:PHA03133  14 DRAAGSPGHNNRRAA---SRPRRQQKASALLRIYVDGPHGLGKTTtaaaLAAALGRRD--DIEYVPEPMAYWQVLgGSET 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13095598  171 HKLIYDVMKMGKHGSFSVSSKLLA---CQMKFLTPLKSLGRVTAMFSGKEM---QRSPGRSDVShwVMFDRHALSACLVF 244
Cdd:PHA03133  89 IARIFDAQHRLDRGEISAGEAAVAmtsAQVTMSTPYAVTEAAVAPHIGGELppgHAPHPNIDLT--LVFDRHPVAPLLCY 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13095598  245 PLVMLKSGMLSFEHFISLVSTF-RANEGDIIVLIALDHGEAIRRIKTRKRPEEE-TISLTYVIRLHWCFVAvyNTWRLLQ 322
Cdd:PHA03133 167 PAARYLMGSLSLPAVLSFAALLpPTTPGTNLVLGALPEAAHAERLAQRQRPGERlDLAMLSAIRRVYDMLG--NTIRYLQ 244
dNK cd01673
Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to ...
 127-318 1.18e-07

Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1.113), adenosine (EC 2.7.1.76), and thymidine (EC 2.7.1.21) kinases. They are key enzymes in the salvage of deoxyribonucleosides originating from extra- or intracellular breakdown of DNA.


Pssm-ID: 238836  Cd Length: 193  Bit Score: 51.84  E-value: 1.18e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13095598 127 FIFFEGVMGVGKTTLLKTLArnDMNNVIIFEEAmNYWKTVFSDCHKLIYDvmKMGKHgSFSVsskllacQMKFLtplksL 206
Cdd:cd01673   1 VIVVEGNIGAGKSTLAKELA--EHLGYEVVPEP-VEPDVEGNPFLEKFYE--DPKRW-AFPF-------QLYFL-----L 62

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13095598 207 GRVTAMfsgKEMQRSPGRSDVshwVMFDRHALSACLVFpLVMLKSGMLSF-------EHFISLVSTFRANegDIIVLIAL 279
Cdd:cd01673  63 SRLKQY---KDALEHLSTGQG---VILERSIFSDRVFA-EANLKEGGIMKteydlynELFDNLIPELLPP--DLVIYLDA 133

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 13095598 280 DHGEAIRRIKTRKRPEEETISLTYVIRLHwcfvAVYNTW 318
Cdd:cd01673 134 SPETCLKRIKKRGRPEEQGIPLDYLEDLH----EAYEKW 168
Herpes_TK_C pfam08465
Thymidine kinase from Herpesvirus C-terminal; This domain is found towards the C terminus in ...
 404-436 8.40e-06

Thymidine kinase from Herpesvirus C-terminal; This domain is found towards the C terminus in Herpesvirus Thymidine kinases.


Pssm-ID: 285639  Cd Length: 33  Bit Score: 42.47  E-value: 8.40e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 13095598   404 KYIGDVRGLWEDISTQILQSRVIKTRPVDWANL 436
Cdd:pfam08465   1 EFRDDVPGLWTEIYMQILKNPAIKTRVIDWTAL 33
PHA03138 PHA03138
thymidine kinase; Provisional
 128-322 1.75e-05

thymidine kinase; Provisional


Pssm-ID: 165410  Cd Length: 340  Bit Score: 46.51  E-value: 1.75e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13095598  128 IFFEGVMGVGKTTLLKTL---ARNDMNNVIIFEEAMNYWKTVF-SDCHKLIYDVMKMGKHGSFSV--SSKLLA-CQMKFL 200
Cdd:PHA03138  15 IYLDGAFGIGKTTAAEAFlhgFAINPNRIFFIGEPLMYWRNLAgDDAICGIYGTQTRRKNGDISDedAQRLTAhFQGLFC 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13095598  201 TPLKSL-GRVTAMfsgkeMQRSPGRSDVSHW------VMFDRHALSACLVFPLVMLKSGMLSFEHFISLVSTFRAN-EGD 272
Cdd:PHA03138  95 SPHAILhAKILAL-----MDQNPNDLALKFFkepvaiFLSDRHPIASNICFPISRYLVGDMSPAALPGFLFALPAEpEGT 169

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 13095598  273 IIVLIALDHGEAIRRIKTRKRPeEETISLTYVIRLHWCFVAVYNTWRLLQ 322
Cdd:PHA03138 170 NLIVCTVSLPNHLSRISKRARP-GEIIDLPFILVLRNVYIMLINTIIFLK 218
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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