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Conserved domains on  [gi|1316058745|ref|XP_023205464|]
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alpha-2,8-sialyltransferase 8F-like isoform X3 [Xiphophorus maculatus]

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 10466376)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.-.-
Gene Ontology:  GO:0006486|GO:0008373
PubMed:  9334165

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 34-300 4.05e-171

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


:

Pssm-ID: 467699  Cd Length: 271  Bit Score: 474.82  E-value: 4.05e-171
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745  34 QQLSSRCHGLDKAIISQMNTPLGSKLVYDGEKKRAAQINAELFSTFPKVSPFSNKTMASCAVVGNGGILANSQCGKMIDS 113
Cdd:cd23971     8 SELRSCCNASHELVVTQENTPLGSKIHYEGERKKTITVNEKLFSMLPKESPFSNKPLKTCAVVGNGGILKNSSCGREIDS 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745 114 AEFVIRCNLPPVSDgyEKHVGSKTNLVTVNPSILLDKYGSLMTRRRPFVEKLRNYGDSMMLLPAFSFGMNTPVSLRAFYT 193
Cdd:cd23971    88 ADFVIRCNLPPLND--SKDVGSKTNLVTANPSILREKFHNLKKRRRPFVERMKVYGNALLLLPAFSYTSNTEPSLRALYT 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745 194 VEDFKSPIRPLFLNPQYLESLDVFWKSQGVKAQRLSSGIMMISLALEICDNVHLYGFWPFSIHPHsFQDLSNHYYDDKQD 273
Cdd:cd23971   166 LEDFGSPQKVLFFNPEYLRNLSRYWKSKGLKARRLSTGLMLVSAALELCENVHLYGFWPFSTDLD-GNPISHHYYDNVLP 244

                         250       260
                  ....*....|....*....|....*..
gi 1316058745 274 KKNFHAMPTEFNLLLKLHTQGVLHLHL 300
Cdd:cd23971   245 KKGVHAMPEEFLRYLKLHSQGVLRLHL 271
 
Name Accession Description Interval E-value
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 34-300 4.05e-171

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 474.82  E-value: 4.05e-171
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745  34 QQLSSRCHGLDKAIISQMNTPLGSKLVYDGEKKRAAQINAELFSTFPKVSPFSNKTMASCAVVGNGGILANSQCGKMIDS 113
Cdd:cd23971     8 SELRSCCNASHELVVTQENTPLGSKIHYEGERKKTITVNEKLFSMLPKESPFSNKPLKTCAVVGNGGILKNSSCGREIDS 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745 114 AEFVIRCNLPPVSDgyEKHVGSKTNLVTVNPSILLDKYGSLMTRRRPFVEKLRNYGDSMMLLPAFSFGMNTPVSLRAFYT 193
Cdd:cd23971    88 ADFVIRCNLPPLND--SKDVGSKTNLVTANPSILREKFHNLKKRRRPFVERMKVYGNALLLLPAFSYTSNTEPSLRALYT 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745 194 VEDFKSPIRPLFLNPQYLESLDVFWKSQGVKAQRLSSGIMMISLALEICDNVHLYGFWPFSIHPHsFQDLSNHYYDDKQD 273
Cdd:cd23971   166 LEDFGSPQKVLFFNPEYLRNLSRYWKSKGLKARRLSTGLMLVSAALELCENVHLYGFWPFSTDLD-GNPISHHYYDNVLP 244

                         250       260
                  ....*....|....*....|....*..
gi 1316058745 274 KKNFHAMPTEFNLLLKLHTQGVLHLHL 300
Cdd:cd23971   245 KKGVHAMPEEFLRYLKLHSQGVLRLHL 271
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 47-295 1.83e-105

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 308.00  E-value: 1.83e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745  47 IISQMNTPLGSKLVYdGEKKRAAQINAELFSTFPKVSPFSNKTMASCAVVGNGGILANSQCGKMIDSAEFVIRCNLPPVs 126
Cdd:pfam00777   1 FLTKENFPLGEWIRY-SEWWLPFTVTEELLELLPKVSPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPT- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745 127 DGYEKHVGSKTNLVTVNP-SILLDKYGSLMTR--RRPFVEKLRNY--GDSMMLLPAFSFGMNTPVSLRAFYTVEDFKSPI 201
Cdd:pfam00777  79 KGYEKDVGSKTTLRTMNPeSAIDSKYGNLGFShpRDPFVEFVLVPfkGRDLLWLPAFLTKGNVSRSLRVLYTLKEVKIPV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745 202 RP---LFLNPQYLESLDVFW-KSQGVKAQRLSSGIMMISLALEICDNVHLYGFWPFsihpHSFQDLSNHYYDDKQDKKN- 276
Cdd:pfam00777 159 DPdkvLFLHPDFLRYVANFWlRSHGLKGRRPSTGLLMLSLALHLCDEVSLYGFGPF----LDSRGNSHHYYDNVLMKKGg 234

                         250       260
                  ....*....|....*....|..
gi 1316058745 277 ---FHAMPTEFNLLLKLHTQGV 295
Cdd:pfam00777 235 fygVHDMPFEFKLLQKLHKEGV 256
 
Name Accession Description Interval E-value
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 34-300 4.05e-171

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 474.82  E-value: 4.05e-171
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745  34 QQLSSRCHGLDKAIISQMNTPLGSKLVYDGEKKRAAQINAELFSTFPKVSPFSNKTMASCAVVGNGGILANSQCGKMIDS 113
Cdd:cd23971     8 SELRSCCNASHELVVTQENTPLGSKIHYEGERKKTITVNEKLFSMLPKESPFSNKPLKTCAVVGNGGILKNSSCGREIDS 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745 114 AEFVIRCNLPPVSDgyEKHVGSKTNLVTVNPSILLDKYGSLMTRRRPFVEKLRNYGDSMMLLPAFSFGMNTPVSLRAFYT 193
Cdd:cd23971    88 ADFVIRCNLPPLND--SKDVGSKTNLVTANPSILREKFHNLKKRRRPFVERMKVYGNALLLLPAFSYTSNTEPSLRALYT 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745 194 VEDFKSPIRPLFLNPQYLESLDVFWKSQGVKAQRLSSGIMMISLALEICDNVHLYGFWPFSIHPHsFQDLSNHYYDDKQD 273
Cdd:cd23971   166 LEDFGSPQKVLFFNPEYLRNLSRYWKSKGLKARRLSTGLMLVSAALELCENVHLYGFWPFSTDLD-GNPISHHYYDNVLP 244

                         250       260
                  ....*....|....*....|....*..
gi 1316058745 274 KKNFHAMPTEFNLLLKLHTQGVLHLHL 300
Cdd:cd23971   245 KKGVHAMPEEFLRYLKLHSQGVLRLHL 271
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 35-300 1.15e-118

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 342.12  E-value: 1.15e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745  35 QLSSRCHGLDKAIISQMNTPLGSKLVYDGEKKRAAQINAELFSTFPKVSPFSNKTMASCAVVGNGGILANSQCGKMIDSA 114
Cdd:cd23991     9 ELSSCCNAVQNFIVSQNNTPLGTNLTYEVEPKKKILITENIFRMFPKSQPFRGYPYKQCAVVGNGGILKNSSCGAEIDQA 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745 115 EFVIRCNLPPVSDGYEKHVGSKTNLVTVNPSILLDKYGSLMTRRRPFVEKLRNYGDSMMLLPAFSFGMNTPVSLRAFYTV 194
Cdd:cd23991    89 DFVFRCNLPPTGGNISKDVGSKTNLVTANPSIISIKYAKLNERRKPFLETVSVYGDAFLLLPAFSYRSNTALSFKVYYTL 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745 195 EDFKSPIRPLFLNPQYLESLDVFWKSQGVKAQRLSSGIMMISLALEICDNVHLYGFWPFSIHPHSfQDLSNHYYDDKQDK 274
Cdd:cd23991   169 EDFKAKQKVIFFHPIYLKHLAQFWRSKGVQVYRLSTGLMITSAALELCEEVKLYGFWPFSKNTEG-KPISHHYYDNQLPK 247

                         250       260
                  ....*....|....*....|....*.
gi 1316058745 275 KNFHAMPTEFNLLLKLHTQGVLHLHL 300
Cdd:cd23991   248 PGFHSMPKEFYQLLQLHSKGILKLQF 273
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 47-295 1.83e-105

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 308.00  E-value: 1.83e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745  47 IISQMNTPLGSKLVYdGEKKRAAQINAELFSTFPKVSPFSNKTMASCAVVGNGGILANSQCGKMIDSAEFVIRCNLPPVs 126
Cdd:pfam00777   1 FLTKENFPLGEWIRY-SEWWLPFTVTEELLELLPKVSPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPT- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745 127 DGYEKHVGSKTNLVTVNP-SILLDKYGSLMTR--RRPFVEKLRNY--GDSMMLLPAFSFGMNTPVSLRAFYTVEDFKSPI 201
Cdd:pfam00777  79 KGYEKDVGSKTTLRTMNPeSAIDSKYGNLGFShpRDPFVEFVLVPfkGRDLLWLPAFLTKGNVSRSLRVLYTLKEVKIPV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745 202 RP---LFLNPQYLESLDVFW-KSQGVKAQRLSSGIMMISLALEICDNVHLYGFWPFsihpHSFQDLSNHYYDDKQDKKN- 276
Cdd:pfam00777 159 DPdkvLFLHPDFLRYVANFWlRSHGLKGRRPSTGLLMLSLALHLCDEVSLYGFGPF----LDSRGNSHHYYDNVLMKKGg 234

                         250       260
                  ....*....|....*....|..
gi 1316058745 277 ---FHAMPTEFNLLLKLHTQGV 295
Cdd:pfam00777 235 fygVHDMPFEFKLLQKLHKEGV 256
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 30-300 2.34e-102

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 300.72  E-value: 2.34e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745  30 LDNNQQLSSRCHGLDKAIISQMNTPLGSKLVYDGEKKRAAQINAELFSTFPKVSPFSNKTMASCAVVGNGGILANSQCGK 109
Cdd:cd23963     3 LDKFRKELERLLNTRKLFLTQKNTPLGDVLYYSYFKKKTFKITKSLYELLPKTSPFSHKRYKTCAVVGNSGILLGSGCGK 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745 110 MIDSAEFVIRCNLPPVsDGYEKHVGSKTNLVTVNPSILLDKYGSLMTRRRP--FVEKLRNYGDSMMLLPAFSFGMNTPVS 187
Cdd:cd23963    83 EIDSHDFVIRCNLPPI-KGFEKDVGRKTNLTTLNPSILKRRYNSLKKNRDRdkFLNRLKEYNGSILWYPKFSFKSSTNLL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745 188 LRAFYTVEDFKSPIRPLFLNPQYLESLDVFWKSQGVkAQRLSSGIMMISLALEICDNVHLYGFWPFSIHPHSfQDLSNHY 267
Cdd:cd23963   162 LKAARALKKNGLNLTVVYSNPEHFLAVQKFWKRRGL-EKRPSTGLYLVSLALTFCDEIHLYGFWPFPTDPNG-RPVPYHY 239

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1316058745 268 YDD--KQDKKNFHAMPTEFNLLLKLHTQGVLHLHL 300
Cdd:cd23963   240 YDDlsPSTKNKVHNMPEEFKLLRELHKKGVLKLHT 274
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 32-299 3.79e-97

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 287.50  E-value: 3.79e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745  32 NNQQLSSRCHGLDKAIISQMNTPLGSKLVYDGEKKRAAQINAELFSTFPKVSPFSNKTMASCAVVGNGGILANSQCGKMI 111
Cdd:cd23990     6 FKSSLSRCCNAPSFLFTTQKNTPLGTKLKYEVDTSGIYHINSEIFKMFPKDMPYSRSQFKKCAVVGNGGILKNSKCGREI 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745 112 DSAEFVIRCNLPPVSDGYEKHVGSKTNLVTVNPSILLDKYGSLMTRRRPFVEKLRNYGDSMMLLPAFSFGMNTPVSLRAF 191
Cdd:cd23990    86 DSADFVFRCNLPPISEKYVRDVGVKTDVVTINPSIITERFHKLEKWRRPFYEVLQVYENASVVLPAFYNTRNTDVSIRVK 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745 192 YTVEDFKSPIRPLFLNPQYLESLDVFWKSQGVKAQRLSSGIMMISLALEICDNVHLYGFWPFSIHPhSFQDLSNHYYDDK 271
Cdd:cd23990   166 YVLDDFESQQAVYYFHPQYLLNVSRFWLRQGVRAKRISSGLMLVTAALELCEEVHLYGFWAFPMNP-SGIFITHHYYDNV 244

                         250       260
                  ....*....|....*....|....*...
gi 1316058745 272 QDKKNFHAMPTEFNLLLKLHTQGVLHLH 299
Cdd:cd23990   245 KPRPGFHAMPSEIFNFLHMHSRGILRVH 272
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 48-300 1.95e-95

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 283.26  E-value: 1.95e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745  48 ISQMNTPLGSKLVYDGEKKRAAQINAELFSTFPKVSPFSnKTMASCAVVGNGGILANSQCGKMIDSAEFVIRCNLPPVSD 127
Cdd:cd23989    22 VTKHNSPLGKNLWFDGEFLHSHTVDNETYSLFPQDTPLQ-LPLKKCSVVGNGGILKNSGCGQQIDRADFVMRCNLPPLSR 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745 128 GYEKHVGSKTNLVTVNPSILLDKYGSLMTRRRPFVEKLRNYGDSMMLLPAFSFGMNTPVSLRAFYTVEDFKSPIRPLFLN 207
Cdd:cd23989   101 EYTDDVGTKTQLVTANPSIIDKRFQNLLWSRKSFVESMKVYGRSYIYMPAFSMKTGTDPSLRVYYTLADVGANQTVLFAN 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745 208 PQYLESLDVFWKSQGVKAQRLSSGIMMISLALEICDNVHLYGFWPFSIHPHSfQDLSNHYYDDKQDKKNFHAMPTEFNLL 287
Cdd:cd23989   181 PNFLRNVGKFWKSKGVHAKRLSTGLFLVSAALGLCEEVTIYGFWPFSVDLDE-RTISHHYYDNVLPDSGFHAMPEEFLQL 259

                         250
                  ....*....|...
gi 1316058745 288 LKLHTQGVLHLHL 300
Cdd:cd23989   260 WHLHKSGVLRMQL 272
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 71-300 3.82e-77

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 236.91  E-value: 3.82e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745  71 INAELFSTFPKVSPFSNKTMASCAVVGNGGILANSQCGKMIDSAEFVIRCNLPPVsDGYEKHVGSKTNLVTVNPSILLDK 150
Cdd:cd23970    49 ISPNLRSLLPEVSPFQNKHYNTCAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPT-EGFEKDVGRKTNLTTFNPSILEKY 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745 151 YGSLMTR--RRPFVEKLRNYGDSMMLLPAFSFGMNTPVslraFYTVEDFKSPIRPlFLNPQ------YLESLDVFWKSQG 222
Cdd:cd23970   128 YNNLLTIqdRNNFFLSLKKLDGAILWIPAFFFHTSATV----TRTLVDFFVEHRG-QLKVQlawpgnIMQHVNRYWKTKH 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745 223 VKAQRLSSGIMMISLALEICDNVHLYGFWPFSIHPHSfQDLSNHYYDDKQDK-----KNFHAMPTEFNLLLKLHTQGVLH 297
Cdd:cd23970   203 LSPKRLSTGILMYTLASAICEEIHLYGFWPFGFDPTG-TPLPYHYYDKKGTKfttkwQESHQLPAEFVLLYKMHGAGVLK 281


                  ...
gi 1316058745 298 LHL 300
Cdd:cd23970   282 LTL 284
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 56-299 2.15e-71

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 221.90  E-value: 2.15e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745  56 GSKLVYDGEKKRAAQINAELFSTFPKVSPFSNKTMASCAVVGNGGILANSQCGKMIDSAEFVIRCNLPPVsDGYEKHVGS 135
Cdd:cd23969    30 GDRMHYEIDRHKTVNITQDLYQLLPEVSPLKGKHFRTCAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPV-EGYEKDVGT 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745 136 KTNLVTVNPSILLDKYGSLM--TRRRPFVEKLRNYGDSMMLLPAFsfgMNTPVSLRAFYT---VEDFKSPIRPLFLNPQY 210
Cdd:cd23969   109 KSNLTTMNPSVIPHAYGDLVnaTDKEKFVERLRQLGDSILWIPAF---VSKGGEEHVQWTneiILKHKLNVKTAYPPLRL 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745 211 LESLDVFWKSQGVKAQRLSSGIMMISLALEICDNVHLYGFWPFSIHpHSFQDLSNHYYDDKQ--DKKNFHAMPTEFNLLL 288
Cdd:cd23969   186 NHAIRGYWLTTKFRIKRPSTGLLMYTLATRFCDEIHLYGFYPFSED-GNGRAVKYHYYDNRKylTTARPHKMPEEFRALR 264

                         250
                  ....*....|.
gi 1316058745 289 KLHTQGVLHLH 299
Cdd:cd23969   265 SLHQRGALRLH 275
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 56-298 1.53e-55

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 181.31  E-value: 1.53e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745  56 GSKLVYDGEKKRAAQINAELFSTFPKVSPFSNKTMASCAVVGNGGILANSQCGKMIDSAEFVIRCNLPPVsDGYEKHVGS 135
Cdd:cd23988    30 GDVIHYVLDRRRTLNISQNLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPV-VEFAADVGT 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745 136 KTNLVTVNPSILLDKYGSLM--TRRRPFVEKLRNYGDSMMLLPAFSF--GMNTPVSLRAFYTVEDFKspIRPLFLNPQYL 211
Cdd:cd23988   109 KSDFITMNPSVVQRAFGGFRneSDREKFVHRLSMLNDSVLWIPAFMVkgGEKHVEWVNALILKNKLK--VRTAYPSLRLI 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745 212 ESLDVFWKSQGVKAQRLSSGIMMISLALEICDNVHLYGFWPFSIHPHSFQdLSNHYYDDKQDK----KNFHAMPTEFNLL 287
Cdd:cd23988   187 HAVRGYWLTNKVNIKRPSTGLLMYTLATRFCDEIHLYGFWPFPKDANGNP-VKYHYYDDLKYRyfsnAGPHRMPLEFKTL 265

                         250
                  ....*....|.
gi 1316058745 288 LKLHTQGVLHL 298
Cdd:cd23988   266 NVLHNRGALKL 276
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 56-300 3.03e-53

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 175.51  E-value: 3.03e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745  56 GSKLVYDGEKKRAAQINAELFSTFPKVSPFSNKTMASCAVVGNGGILANSQCGKMIDSAEFVIRCNLPPVSDgYEKHVGS 135
Cdd:cd23987    30 GDVIHYVFDRDSTMNISQNLYELLPRTSPLKNKHFKTCAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEE-YAKDVGT 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745 136 KTNLVTVNPSILLDKYGSLM--TRRRPFVEKLRNYGDSMMLLPAFsfgMNTPVSLRAFYTVE---DFKSPIRPLFLNPQY 210
Cdd:cd23987   109 KTDLVTMNPSVVQRAFEDLVneTWKEKFLQRLQSLNGSILWIPAF---MAKGGEERVEWVNDlilKHHINVRTAYPSLRL 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745 211 LESLDVFWKSQGVKAQRLSSGIMMISLALEICDNVHLYGFWPFSIHPHSfQDLSNHYYDDKQ----DKKNFHAMPTEFNL 286
Cdd:cd23987   186 LHAVRGYWLTNKVHIKRPTTGLLMYTLATRFCNRIHLYGFWPFPRDQNQ-NPVKYHYYDSLKygytSQASPHTMPLEFKA 264

                         250
                  ....*....|....
gi 1316058745 287 LLKLHTQGVLHLHL 300
Cdd:cd23987   265 LKNLHQQGALKLTV 278
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 93-290 5.40e-39

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 135.95  E-value: 5.40e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745  93 CAVVGNGGILANSQCGKMIDSAEFVIRCNLPPVSdGYEKHVGSKTNLVTVNPSILldkyGSLMTRRRPFVEKLRNYGDSM 172
Cdd:cd19952     1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTK-GFEKDVGSKTTFRVLNSKWA----GFYLRGPRCGCHPLPLEEEVV 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745 173 MLLPAFSFGMNTPVSLRAFYTVED--FKSPIRPLFLNP--QYLESLDVFWKSQGVKAqrlSSGIMMISLALEICDNVHLY 248
Cdd:cd19952    76 LILSRAAAADFKRLKRRKKRHDNAvlLLTDPAPDLLSYvrKRLEKLGLKSFFGGNAP---SSGLLAVLLALQLCDSVDLY 152

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1316058745 249 GFWPFSIHPHSFQdlsNHYYDDKQDKK--NFHAMPTEFNLLLKL 290
Cdd:cd19952   153 GFGVDSGHAPKVP---YHYYDLVEAEEgtAVHSFDLEAELLRAL 193
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 93-290 8.19e-23

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 93.51  E-value: 8.19e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745  93 CAVVGNGGILANSQCGKMIDSAEFVIRCNLPPVSdGYEKHVGSKTNLVTVNP-SILLDkygslmtrrrpfveKLRNYGDS 171
Cdd:cd23967     5 CVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVK-GYEKDVGSKTTFRMFYPeSAFRD--------------PEEYDSDW 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745 172 MMLLPAFSfgmntPVSLRAFYTV--------EDF----------KSPIRPLFLNPQYLESLDV----FWKSQGVKAQRLS 229
Cdd:cd23967    70 LLVLVPFK-----SMDLLWLQAVikgkkpngKGGfwkkiatsvpKPPKKIRILNPYILQEAAFdligLPMNGKQGKNVPT 144

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1316058745 230 SGIMMISLALEICDNVHLYGFWpfsiHPHSFQDLSNHYYDD---KQDKKNF-HAMPTEFNLLLKL 290
Cdd:cd23967   145 TGIIAIVMALHYCDEVDIAGFG----YDPSDPNAPLHYYDSltmKAIKRSWtHNVTKEKKYLKKL 205
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 92-299 4.86e-21

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 90.78  E-value: 4.86e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745  92 SCAVVGNGGILANSQCGKMIDSAEFVIRCNLpPVSDGYEKHVGSKT---------NLVTVNPSILLDK---YGSLMTRRR 159
Cdd:cd23964    84 RCAVVGNGGILNGSGKGKEIDAHDYVFRVNH-ALTKGFEKDVGTKTsfytffpesLHNSLLKHVPQDKdtkYLFIPFKIR 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745 160 PFVeklrnYGDSMML---LPAFSFGMNTPVSLRA-FYTVEDFKS--P--IRPLFLNpqYLESLDVFwksqgvkaqRLSSG 231
Cdd:cd23964   163 DYD-----YLDAVLSgkpVPDGCDKGKRPPPLFGpKLNATNVRLlhPdfIRYLFNR--WLNSSTSY---------RPTTG 226

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1316058745 232 IMMISLALEICDNVHLYGFwpfsIHPHSFqdlSNHYYDDK-QDKKNF---HAMPTEFNLLLKLHTQGVLHLH 299
Cdd:cd23964   227 ALMLLTALHTCDQVSVYGF----GYDPRF---SLHYYDKTfVKFTVFyanHDFTNERKLWRKLHEEGIINLY 291
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 74-301 2.95e-20

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 89.04  E-value: 2.95e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745  74 ELFSTFPK--------VSPFSNKTMASCAVVGNGGILANSQCGKMIDSAEFVIRCNlPPVSDGYEKHVGSKTNL-VTVNP 144
Cdd:cd23973    59 EVVELIPKpkeqqllaLSPPGGDGCIRCAVVGNGGILNGSKMGQEIDSHDYVFRVN-GAVIKGYEEDVGTRTSFyVHTAH 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745 145 SIL--LDKYGSLMTRRRP---------FVEKLRNYG--DSMMLLPAFSFGMNTPVSLRAFYTvEDFkSPIRPLFLNPQYL 211
Cdd:cd23973   138 SITssLMILQKRGFKNIPqdkdikyilFPEGPRDYQwlEALLKNKTIPSGAYYGRRPRSYFS-GDF-TEDKYLVLHPDFL 215

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745 212 ESL-DVFWKSQGVKAQ-----RLSSGIMMISLALEICDNVHLYGFWpfsihPHSFQDLSNHYYDDKQDKKNF---HAMPT 282
Cdd:cd23973   216 RYVkNRFLRSKTLKGKywaiyRPTTGAFLLLTALHLCDTVSAYGFI-----TEDYRKYPDHYYDKKKTKLVFyinHDFRL 290

                         250
                  ....*....|....*....
gi 1316058745 283 EFNLLLKLHTQGVLHLHLG 301
Cdd:cd23973   291 EKKLWKRLHDEKIIKLYQR 309
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 92-290 1.85e-19

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 84.72  E-value: 1.85e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745  92 SCAVVGNGGILANSQCGKMIDSAEFVIRCNLPPVSdGYEKHVGSKTNLVTVNP-SILLDkygslmtrrrPFVEklrNYGD 170
Cdd:cd23982     4 RCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVR-GFEKDVGSKTTIRLFYPeSAQFD----------PGIE---NDPD 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745 171 SMMLLPAFSfgmntPVSLRAFYTV---------EDFKSPIR-----PLF---LNPQYLES-----LDVfwKSQGVKAQRL 228
Cdd:cd23982    70 TLLVLVPFK-----PLDFYWLYEIlsnekrvrkGFWKQPPRiwdanPKQiriLNPYYTYVaatklLQV--PGQRKKKQKP 142

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1316058745 229 SSGIMMISLALEICDNVHLYGF-WPFSIHPHSFQdlsnHYYDD---KQDKKNFHAMPTEFNLLLKL 290
Cdd:cd23982   143 TTGLLAITLALHLCDEVHIAGFgYPDNGNSNQPI----HYYNQitlKSMANSGHNLNAEAQAIQRL 204
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 73-299 4.40e-19

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 85.02  E-value: 4.40e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745  73 AELFSTFPKVSPFSNKTMA---SCAVVGNGGILANSQCGKMIDSAEFVIRCNLPPVSdGYEKHVGSKT--------NLVT 141
Cdd:cd23966    57 EKLFQVVPGENPYRTRDPNrcrRCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTK-GFEKDVGSKTthhfmypeSAVD 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745 142 VNPS---ILLdkygslmtrrrPFveKLRnygDSMMLLPAFSFG--MNTPVSLRAFYTVEdfKSPIrpLFLNPQYLEslDV 216
Cdd:cd23966   136 LDPGvhlVLV-----------PF--KVL---DLQWLISALTTGeiTRTYTPVKRFIKAD--KDKV--LVINPAFIK--YV 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745 217 FWKSQGVKAQRLSSGIMMISLALEICDNVHLYGF-------WpfsihphsfqdlsNHYYDDKQDKKNF-----HAMPTEF 284
Cdd:cd23966   194 HDNWTEHHGRYPSTGFLALIFALHICDEVSVFGFgadskgnW-------------HHYWEKNRSAGAFrktgvHDADFES 260

                         250
                  ....*....|....*
gi 1316058745 285 NLLLKLHTQGVLHLH 299
Cdd:cd23966   261 DIIKKLAKEGKIRVY 275
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 93-300 7.17e-19

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 85.19  E-value: 7.17e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745  93 CAVVGNGGILANSQCGKMIDSAEFVIRCNlPPVSDGYEKHVGSKTNLVTVNPSIL---LDKYGSLMTRRRPFVEKLR--- 166
Cdd:cd23974    87 CAVVGNGGILNGSRMGAEIDGHDYVFRVN-GAITKGFEKDVGRRTSFYTFSTNTLmnsLRAYAGVGFNGPPQSKETRyif 165

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745 167 --NYGDSMMLLPAFSfgMNTPVS---------LRAF---YTVEDFK--SPIRPLFLNPQYLESldVFWKSQGVKAQRLSS 230
Cdd:cd23974   166 lpDHDRDYLLVKAAL--THTPIDrgrdkskrpSKYFgkdVTAEKFKiyHPDFIRYLRNRFLWS--PILNTKQRDIYRPST 241

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1316058745 231 GIMMISLALEICDNVHLYGFwpfsIHPhSFQDLSNHYYDDKQDKKNF---HAMPTEFNLLLKLHTQGVLHLHL 300
Cdd:cd23974   242 GAVMLLAALHTCDQVSAYGF----MTP-DYGKYSDHYYDKTYHKVVFyanHDLRLEMQLWQKLHKAGLIKLYM 309
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 72-292 3.85e-18

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 82.32  E-value: 3.85e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745  72 NAELFSTFPKVSPFSN-----------------KTMASCAVVGNGGILANSQCGKMIDSAEFVIRCNLPPVsDGYEKHVG 134
Cdd:cd23968    10 KAAPFSTLRKTTSPFKdllslrypfpesslentKRYNTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPT-KGFEKDVG 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745 135 SKTNLVTVNPSIlldkygsLMTRRRPFVEKLRnYGDSMMLlpAFSFGMNTpVSLRAFYTVEDFKS-----------PIRP 203
Cdd:cd23968    89 SKTTLRLINSQI-------LSKPEFNFLTDPL-YRNVTLL--VWDPSSYN-VNLEKWYKKPDFDFfpnyikyrrrhPEEP 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745 204 LFL-NPQYLESL-DVFWKSQGVKAQRL--SSGIMMISLALEICDNVHLYGFWPfsihphSFQDLSN-HYYDDKQDKK--- 275
Cdd:cd23968   158 FYLiDPRFLWRLwDILQEYTPEKIKPNppSSGFIGIVLMLHLCDWVDVYEYVP------SVRQTDRcHYYDVEKDLActl 231

                         250
                  ....*....|....*...
gi 1316058745 276 -NFHAMPTEFNLLLKLHT 292
Cdd:cd23968   232 gAWHPLAAEKLLVRHLNV 249
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 93-270 5.72e-18

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 80.56  E-value: 5.72e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745  93 CAVVGNGGILANSQCGKMIDSAEFVIRCNLPPVSdGYEKHVGSKTNLVTVNP-SIlldkygslmtrrrpFVEKLRNYGDS 171
Cdd:cd23984     5 CVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVI-GYENDVGKRTTFRLCYPeSI--------------FSDPSHYDPNT 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745 172 MMLLPAF---------SFGMNTPVSLRAFYTVEDFK---SPIRPLFLNPQYLESL--------DVFWKSQgvKAQRLSSG 231
Cdd:cd23984    70 TVVLIPFkphdlrwllDLLMGKKVSAKGFWKKPALNliyKPNQIRILNPFILRIAayellhfpKRFPKEK--KPKHPTTG 147

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1316058745 232 IMMISLALEICDNVHLYGFwpfsihPHSFQDLSN--HYYDD 270
Cdd:cd23984   148 IIAITLALHICNEVHIAGF------KYDFSNLNStlHYYGN 182
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 6-299 1.88e-16

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 78.33  E-value: 1.88e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745   6 GQLLNLMIGLLFLASLLTTFMWymldnnQQLSSR-----CHGLDKAIISQmntplGSKLVYDGEkkraaqiNAELFstFP 80
Cdd:cd23972    16 RGLFNFDIPVLLWGQHFTPALW------DRLSQRkvpygWKGLSHQVVAS-----TLSLLNDSA-------NAKLF--FP 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745  81 KVSPfsnKTMASCAVVGNGGILANSQCGKMIDSAEFVIRCNlPPVSDGYEKHVGSKTNL--VTVNP-SILLDKYGSLMTR 157
Cdd:cd23972    76 RDTP---GKCIRCAVVGNGGILNGSRQGRAIDAHDYVFRLN-GAVIKGFEEDVGTKTSFygFTVNTmKNSLISYWNLGFT 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745 158 RRPFVEKLR------NYGDSMMLLPAFsFGMNTPVSL------RAFYTVEdfKSPIRPLFLNPQYLESL-DVFWKSQGVK 224
Cdd:cd23972   152 RTPQGQDLQyifipsDIRDYVMLRSAI-LGVPVPEGLdkgdrpHKYFGPE--ASAKKFKLLHPDFISYLtDRFLKSKLLN 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745 225 AQ-----RLSSGIMMISLALEICDNVHLYGFwpfsIHPhSFQDLSNHYYDDKQDKKNF---HAMPTEFNLLLKLHTQGVL 296
Cdd:cd23972   229 THyghlyMPSTGALMLLTALHTCDQVSAYGF----ITS-NYWKFSDHYYERKKKPLVFyanHDMLLEAALWRRLHKAGIL 303


                  ...
gi 1316058745 297 HLH 299
Cdd:cd23972   304 QLY 306
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 92-270 8.35e-16

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 74.97  E-value: 8.35e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745  92 SCAVVGNGGILANSQCGKMIDSAEFVIRCNLPPVSdGYEKHVGSKTNL-----VTVnPSILLDKYGSLMTRRRPfveklr 166
Cdd:cd23965     3 TCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTR-GYEKDVGRRTTIrvvshSSL-PRLLRNAILLLAGTRAP------ 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745 167 nygdsMMLLPafsFGMNTPVSLRAFYTVE-----DFKSP-IRPLFLNPQYLESLD-VFWKSQGVKAQR----LSSGIMMI 235
Cdd:cd23965    75 -----TVVVF---WGPETKMNKDGAGKYNllrslSKKYPdVEFYSLTPEKMDYADeLFEKETGKSRIKsgtwLSTGWFTM 146

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1316058745 236 SLALEICDNVHLYGFWP---FSIHPHSfqDLSNHYYDD 270
Cdd:cd23965   147 LLALDVCDEIKVYGMVPenyCREHPNS--KVPYHYYEP 182
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 93-290 1.89e-13

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 68.23  E-value: 1.89e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745  93 CAVVGNGGILANSQCGKMIDSAEFVIRCNLPPVSdGYEKHVGSKTNLVTVNP----SILLDKYGSLMtrrrpFVEKLRNY 168
Cdd:cd23983     5 CVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQ-GYSQDVGNKTTIRMTYPegapKSEQEYDPTSL-----FVAVLFKS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745 169 GDSMMLLPAFSfgmNTPVSL--RAFYTVEDFKS-PIRP---LFLNP-----------QYLESLDVFW-KSQGVKaqrlSS 230
Cdd:cd23983    79 VDFAWLKAMVK---KEPLSFwsRLFFWKEVADSiPLKPsqfRILNPliiketaldilQYPEPQSRLWgWDKNVP----TL 151

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1316058745 231 GIMMISLALEICDNVHLYGFWPFSIHPHsfqdLSNHYYD----DKQDKKNFHAMPTEFNLLLKL 290
Cdd:cd23983   152 GVTAVVLATHLCDEVSLAGFGYDLSQPH----APLHYYDsvcmAAMNTQTMHNVTKETKFLKKL 211
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 74-250 4.39e-13

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 67.98  E-value: 4.39e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745  74 ELFSTFP-KVSPFSNKTMASC---AVVGNGGILANSQCGKMIDSAEFVIRCNLPPvSDGYEKHVGSKTNLVTVNPsilld 149
Cdd:cd23980    61 ELFQVVPgNVDPLLEKRLVSCrrcAVVGNSGNLKESYYGPQIDSHDFVLRMNKAP-TEGFEADVGSKTTHHFVYP----- 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745 150 kygslmtrrrpfvEKLRNYGD--SMMLLPAFSFGMNTPVSLRAFYTVEDFKSPI---------RPLFLNPQYLESLDVFW 218
Cdd:cd23980   135 -------------ESFRELAQnvSMILVPFKTLDLEWVISATTTGTISHTYVPVprkikvkkeKILIYHPAFIKYVFDRW 201

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1316058745 219 KsQGvKAQRLSSGIMMISLALEICDNVHLYGF 250
Cdd:cd23980   202 L-QG-HGRYPSTGILSVIFSLHVCDEVDLYGF 231
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 92-271 1.59e-12

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 65.65  E-value: 1.59e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745  92 SCAVVGNGGILANSQCGKMIDSAEFVIRCNLPPVSdGYEKHVGSKTNL-VTVNPSIlldkYGSLmtrRRPfvEKLRNYGD 170
Cdd:cd23978     3 QCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTT-GYEKDVGNKTTLrVVAHSSV----YRVL---RRP--QEFLNRTP 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745 171 SMMLL----PAfsfGMNTPVSLRAFYTVEDFKSPIRPL---FLNPQYLESLD-VFWKSQGVKAQR----LSSGIMMISLA 238
Cdd:cd23978    73 ETTLIfwgpPN---KMQKDGKSNLFRIIQRASMTFPNMsafVVSPRRMRQFDdLFRGETGRDRKKshswLSTGWFTMVIA 149

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1316058745 239 LEICDNVHLYGFWP--FSIHPHSFQDLSNHYYDDK 271
Cdd:cd23978   150 VELCDNVHVYGMVPpnYCSKRPTPKKMPYHYYEPK 184
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 92-269 5.00e-12

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 64.86  E-value: 5.00e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745  92 SCAVVGNGGILANSQCGKMIDSAEFVIRCNLPPvSDGYEKHVGSKTNLVTVNPSILLDKYGSLMtrRRPFveklrnYGDS 171
Cdd:cd23986    51 SCAVVTSAGAILNSSLGKEIDSHDAVLRFNSAP-TRGYEKDVGNKTTIRIINSQILTNPNHHFI--DSSL------YKDV 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745 172 MMLL--PA-FSfgmntpVSLRAFYTVEDF-----------KSPIRPLF-LNPQYLESL-DVFWKSQGVKAQ--RLSSGIM 233
Cdd:cd23986   122 ILVAwdPApYS------ANLHKWYKKPDYnlftpyvqyrkRNPNQPFYiLHPKFIWQLwDIIQENTQEKIQpnPPSSGFI 195

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1316058745 234 MISLALEICDNVHLYGFWPfSIHPHSFQDLSNHYYD 269
Cdd:cd23986   196 GILIMMSMCREVHVYEYIP-SVRQTDLCHYHERYYD 230
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 93-304 6.49e-12

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 64.73  E-value: 6.49e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745  93 CAVVGNGGILANSQCGKMIDSAEFVIRCNLPPVSdGYEKHVGSKTNLVTVNpsilldkyGSLMTR-RRPFVEK-LRNYGD 170
Cdd:cd23985    48 CAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPTA-GFQQDVGTKTTIRLIN--------SQLVTTeKHKFLKDsLYNEGI 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745 171 SMMLLPAfSFGMNTPvslrafytvEDFKSPIRPLF--------LNPQ---YLESLDVFWK---------SQGVKAQRLSS 230
Cdd:cd23985   119 LIVWDPA-PYHSDIP---------EWYKNPDYNFFenyktyrrLNPNqpfYILHPQMQWElwdiiqensPEEIQPNPPSS 188

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1316058745 231 GIMMISLALEICDNVHLYGFWPfsihPHSFQDLSnHYYDDKQDKK----NFHAMPTEFNLllklhtqgVLHLHLGDCE 304
Cdd:cd23985   189 GMLGIILMMTLCDQVDVYEFLP----SKRKTDVC-HYYQKFFDRActmgAYHPLLYEKNL--------VKHLNQGTDE 253
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 70-250 1.84e-11

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 63.35  E-value: 1.84e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745  70 QINAELFSTFPKVSPFSNKTMASC---AVVGNGGILANSQCGKMIDSAEFVIRCNLPPVSdGYEKHVGSKT--------- 137
Cdd:cd23979    57 EVLSKLFQIIPGENPYRSWDPSRCrrcAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTV-GFEADVGSRTthhfmypes 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745 138 --NLvTVNPSILLDKYGSLmtrrrpfveklrnygDSMMLLPAFSFGM--NTPVSLRAFYTVEDFKSPIrplfLNPQYLES 213
Cdd:cd23979   136 akNL-PANVSFVLVPFKTL---------------DLLWITSALSTGQirFTYAPVKQFLRVDKDKVQI----YNPAFFKY 195

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1316058745 214 LDVFWKSQgvKAQRLSSGIMMISLALEICDNVHLYGF 250
Cdd:cd23979   196 IHDRWTEH--HGRYPSTGMLVLFFALHVCDEVNVYGF 230
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 93-250 1.60e-10

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 59.55  E-value: 1.60e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745  93 CAVVGNGGILANSQCGKMIDSAEFVIRCNLPPVSdGYEKHVGSKTNLVTVNPSilldkyGSlmtrrrpfVEKLRNY-GDS 171
Cdd:cd23981     5 CIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVK-GFEKDVGSKTTLRITYPE------GA--------IQKPEQYeKDS 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745 172 MMLLPAFSFgmntpvslrafytvEDFKSPIRPLFlnPQYLESLDVFWKSQGVKAQR------------------------ 227
Cdd:cd23981    70 LFVLAGFKW--------------QDFKWLKYIVY--KEKVSASDGFWKSVATRVPRepheirilnpyfiqeaafsfiglp 133

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1316058745 228 LSSGIM-----------MISLALEICDNVHLYGF 250
Cdd:cd23981   134 FNNGLMgrgniptlgsvAITMALHNCDEVAVAGF 167
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 92-269 6.85e-08

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 52.56  E-value: 6.85e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745  92 SCAVVGNGGILANSQCGKMIDSAEFVIRCNLPPvSDGYEKHVGSKTNLVTVNPS----ILLDKYGSLMTRRRPFV----- 162
Cdd:cd23976    17 SCALVTSSGHLTGSNRGNEIDETECVIRMNDAP-TRGYGKDVGNKTSLRVIAHSsiqrILRNRNELLNVSQGTVFifwgp 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745 163 -EKLRNygDSMMLLPAFSFGMNTPVSLRAFYTVEdfkspirplflNPQYLESLDVFWKSQGVKAQR----LSSGIMMISL 237
Cdd:cd23976    96 sNYMRR--DGKGLVYNNLQLMNQILPKLKVYTIT-----------RHKMLQFDELFKRETGKDRKIsntwLSTGWFTMII 162

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1316058745 238 ALEICDNVHLYGFWP--FSIHPHSfQDLSNHYYD 269
Cdd:cd23976   163 ALELCDRINVYGMVPpdFCRDPNH-PSVPYHYYE 195
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 92-249 3.25e-07

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 50.25  E-value: 3.25e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745  92 SCAVVGNGGILANSQCGKMIDSAEFVIRCNLPPVSdGYEKHVGSKTNLVTVNPS---ILLDKYGSLMTRRRPFVEKLRNY 168
Cdd:cd23977     3 RCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTA-GYEADVGNRSSLRVVSHTsvpLLLRNQGYFFQQSRDTKYVIWGP 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1316058745 169 GDSMMllpafsfGMNTPVSLRAFYTVEDFKSPIRPLFLNPQYLESLDVFWKSQGVKAQR-----LSSGIMMISLALEICD 243
Cdd:cd23977    82 ERNMD-------RDGGGKTYRALLTLAKMYPHLQVYTLTEEKMAYCDGVFQNETGKNRMksgsfLSTGWFTMILALELCE 154


                  ....*.
gi 1316058745 244 NVHLYG 249
Cdd:cd23977   155 EILVYG 160
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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