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Conserved domains on  [gi|1335892|gb|AAB01100|]
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ASH1 [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SET_ASH1L cd19174
SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ...
 1375-1515 1.35e-93

SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ASH1L (EC 2.1.1.43; also termed absent small and homeotic disks protein 1 homolog, KMT2H, or lysine N-methyltransferase 2H) acts as histone-lysine N-methyltransferase that specifically methylates 'Lys-36' of histone H3 (H3K36me). It plays important roles in development; heterozygous mutation of ASH1L is associated with severe intellectual disability (ID) and multiple congenital anomaly (MCA).


:

Pssm-ID: 380951 [Multi-domain]  Cd Length: 141  Bit Score: 298.82  E-value: 1.35e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892  1375 GVERFMTADKGWGVRTKLPIAKGTYILEYVGEVVTEKEFKQRMASIYLNDTHHYCLHLDGGLVIDGQRMGSDCRFVNHSC 1454
Cdd:cd19174    1 GLERFRTEDKGWGVRTKEPIKAGQFIIEYVGEVVSEQEFRRRMIEQYHNHSHHYCLNLDSGMVIDGYRMGNEARFVNHSC 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1335892  1455 EPNCEMQKWSVNGLSRMVLFAKRAIEEGEELTYDYNFSLFNPSEGQPCRCNTPQCRGVIGG 1515
Cdd:cd19174   81 DPNCEMQKWSVNGVYRIGLFALKDIPAGEELTYDYNFHSFNVEKQQPCKCGSPNCRGVIGG 141
BAH_polybromo cd04717
BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human ...
 1913-2057 1.51e-51

BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human polybromo protein (BAF180) is a component of the SWI/SNF chromatin-remodeling complex PBAF. It is thought that polybromo participates in transcriptional regulation. Saccharomyces cerevisiae RSC1 and RSC2 are part of the 15-subunit nucleosome remodeling RSC complex. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the remodeling of chromatin. It is assumed that in most or all of these instances the BAH domain mediates protein-protein interactions.


:

Pssm-ID: 240068  Cd Length: 121  Bit Score: 177.78  E-value: 1.51e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892  1913 DLQVRQGDAVYVLRDIpikdesgkvlptkkhtyetigaiDYQECDIFRVEHLWKNELGKRFIFGQHFLRPHETFHEPSRR 1992
Cdd:cd04717    1 GLQYRVGDCVYVANPE-----------------------DPSKPIIFRIERLWKDEDGEKFFFGCWFYRPEETFHEPTRK 57

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1335892  1993 FYPNEVVRVSLYEVVPIELVIGPCWLLDRPTFSKGPPMECNDEDhCYICELRVDKTARFFSKAKA 2057
Cdd:cd04717   58 FYKNEVFKSPLYETVPVEEIVGKCAVMDVKDYIKGRPTEISEED-VYVCESRYNESAKSFKKIKT 121
Bromo_ASH1 cd05525
Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the ...
 1664-1771 9.27e-40

Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the trithorax-group in Drosophila melanogaster, an epigenetic transcriptional regulator of HOX genes. Drosophila ASH1 has been shown to methylate specific lysines in histones H3 and H4. Mammalian ASH1 has been shown to methylate histone H3. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


:

Pssm-ID: 99955 [Multi-domain]  Cd Length: 106  Bit Score: 143.30  E-value: 9.27e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892  1664 AKMAVVLRDICSAMETLKMSDLLTTVSSKKKKPIKTtlSGKLGSTAATSKVEFRSIQAQVEQGHYKTPQEFDDHMQQLFV 1743
Cdd:cd05525    1 ARLAQVLKEICDAIITYKDSNGQSLAIPFINLPSKK--KNPDYYERITDPVDLSTIEKQILTGYYKTPEAFDSDMLKVFR 78

                         90       100
                 ....*....|....*....|....*...
gi 1335892  1744 EAKQQHGDDEGKEKALQSLKDSYEQQKI 1771
Cdd:cd05525   79 NAEKYYGRKSPIGRDVCRLRKAYYQAKH 106
PHD_ASH1L cd15548
PHD finger found in histone-lysine N-methyltransferase ASH1L; ASH1L, also termed ASH1-like ...
 1842-1884 4.99e-25

PHD finger found in histone-lysine N-methyltransferase ASH1L; ASH1L, also termed ASH1-like protein, or absent small and homeotic disks protein 1 homolog, or lysine N-methyltransferase 2H, is a protein belonging to the Trithorax family. It methylates Lys36 of histone H3 independently of transcriptional elongation to promote the establishment of Hox gene expression by counteracting Polycomb silencing. It can suppress interleukin-6 (IL-6), and tumor necrosis factor (TNF) production in Toll-like receptor (TLR)-triggered macrophages, and inflammatory autoimmune diseases by inducing the ubiquitin-editing enzyme A20. ASH1L contains an associated with SET domain (AWS), a SET domain, a post-SET domain, a bromodomain, a bromo-adjacent homology domain (BAH), and a plant homeodomain (PHD) finger.


:

Pssm-ID: 277023  Cd Length: 43  Bit Score: 99.08  E-value: 4.99e-25
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 1335892  1842 IRCICGLYKDEGLMIQCSKCMVWQHTECTKADIDADNYQCERC 1884
Cdd:cd15548    1 IRCICGLYKDEGLMIQCEKCMVWQHCDCMGVNDDVEHYLCEQC 43
AWS smart00570
associated with SET domains; subdomain of PRESET
 1324-1372 2.63e-16

associated with SET domains; subdomain of PRESET


:

Pssm-ID: 197795  Cd Length: 50  Bit Score: 74.74  E-value: 2.63e-16
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|.
gi 1335892     1324 DHPTCNCKNQ--GEKSCLDNCLNRMVYTECsPSNCPAGEKCRNQKIQRHAV 1372
Cdd:smart00570    1 DIMTCECKPTddDETACGSDCLNRMLFIEC-SSSCPCGSYCSNQRFQKRQY 50
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 1002-1265 3.34e-05

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.55  E-value: 3.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892   1002 PNPPLDCERVPQAGEARetfvARTNQKAPRLSVVALE-RLQRPQTPAR-GRPRG-RKPKNREQAEAAPQPPPKSEPEIRP 1078
Cdd:PHA03247 2551 PPPPLPPAAPPAAPDRS----VPPPRPAPRPSEPAVTsRARRPDAPPQsARPRApVDDRGDPRGPAPPSPLPPDTHAPDP 2626

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892   1079 AKKRGR-QPKQPVLEEPPPTPPPQQKKNKMEP-NIRLP---DGIDPNTNFSCKIRLKRRKNLEAGTQPKKE--KPVQPVT 1151
Cdd:PHA03247 2627 PPPSPSpAANEPDPHPPPTVPPPERPRDDPAPgRVSRPrraRRLGRAAQASSPPQRPRRRAARPTVGSLTSlaDPPPPPP 2706

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892   1152 VEEIPPEIPVSQEEIDAEAEAKRVDSIPTEHDP----------LPASESHNPGPQDYASCSESSEDKA-STTSLRKLSKV 1220
Cdd:PHA03247 2707 TPEPAPHALVSATPLPPGPAAARQASPALPAAPappavpagpaTPGGPARPARPPTTAGPPAPAPPAApAAGPPRRLTRP 2786

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1335892   1221 KKTYLVAGLLSNHYKQSLMPPPAKVN-KKPGLEEQVGPASLLPPPP 1265
Cdd:PHA03247 2787 AVASLSESRESLPSPWDPADPPAAVLaPAAALPPAASPAGPLPPPT 2832
 
Name Accession Description Interval E-value
SET_ASH1L cd19174
SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ...
 1375-1515 1.35e-93

SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ASH1L (EC 2.1.1.43; also termed absent small and homeotic disks protein 1 homolog, KMT2H, or lysine N-methyltransferase 2H) acts as histone-lysine N-methyltransferase that specifically methylates 'Lys-36' of histone H3 (H3K36me). It plays important roles in development; heterozygous mutation of ASH1L is associated with severe intellectual disability (ID) and multiple congenital anomaly (MCA).


Pssm-ID: 380951 [Multi-domain]  Cd Length: 141  Bit Score: 298.82  E-value: 1.35e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892  1375 GVERFMTADKGWGVRTKLPIAKGTYILEYVGEVVTEKEFKQRMASIYLNDTHHYCLHLDGGLVIDGQRMGSDCRFVNHSC 1454
Cdd:cd19174    1 GLERFRTEDKGWGVRTKEPIKAGQFIIEYVGEVVSEQEFRRRMIEQYHNHSHHYCLNLDSGMVIDGYRMGNEARFVNHSC 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1335892  1455 EPNCEMQKWSVNGLSRMVLFAKRAIEEGEELTYDYNFSLFNPSEGQPCRCNTPQCRGVIGG 1515
Cdd:cd19174   81 DPNCEMQKWSVNGVYRIGLFALKDIPAGEELTYDYNFHSFNVEKQQPCKCGSPNCRGVIGG 141
BAH_polybromo cd04717
BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human ...
 1913-2057 1.51e-51

BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human polybromo protein (BAF180) is a component of the SWI/SNF chromatin-remodeling complex PBAF. It is thought that polybromo participates in transcriptional regulation. Saccharomyces cerevisiae RSC1 and RSC2 are part of the 15-subunit nucleosome remodeling RSC complex. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the remodeling of chromatin. It is assumed that in most or all of these instances the BAH domain mediates protein-protein interactions.


Pssm-ID: 240068  Cd Length: 121  Bit Score: 177.78  E-value: 1.51e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892  1913 DLQVRQGDAVYVLRDIpikdesgkvlptkkhtyetigaiDYQECDIFRVEHLWKNELGKRFIFGQHFLRPHETFHEPSRR 1992
Cdd:cd04717    1 GLQYRVGDCVYVANPE-----------------------DPSKPIIFRIERLWKDEDGEKFFFGCWFYRPEETFHEPTRK 57

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1335892  1993 FYPNEVVRVSLYEVVPIELVIGPCWLLDRPTFSKGPPMECNDEDhCYICELRVDKTARFFSKAKA 2057
Cdd:cd04717   58 FYKNEVFKSPLYETVPVEEIVGKCAVMDVKDYIKGRPTEISEED-VYVCESRYNESAKSFKKIKT 121
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 1376-1496 1.59e-43

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 154.80  E-value: 1.59e-43
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892     1376 VERFMTADKGWGVRTKLPIAKGTYILEYVGEVVTEKEFKQRMaSIYLNDT--HHYCLHLDGGLVIDGQRMGSDCRFVNHS 1453
Cdd:smart00317    3 LEVFKSPGKGWGVRATEDIPKGEFIGEYVGEIITSEEAEERP-KAYDTDGakAFYLFDIDSDLCIDARRKGNLARFINHS 81

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|...
gi 1335892     1454 CEPNCEMQKWSVNGLSRMVLFAKRAIEEGEELTYDYNFSLFNP 1496
Cdd:smart00317   82 CEPNCELLFVEVNGDDRIVIFALRDIKPGEELTIDYGSDYANE 124
Bromo_ASH1 cd05525
Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the ...
 1664-1771 9.27e-40

Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the trithorax-group in Drosophila melanogaster, an epigenetic transcriptional regulator of HOX genes. Drosophila ASH1 has been shown to methylate specific lysines in histones H3 and H4. Mammalian ASH1 has been shown to methylate histone H3. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99955 [Multi-domain]  Cd Length: 106  Bit Score: 143.30  E-value: 9.27e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892  1664 AKMAVVLRDICSAMETLKMSDLLTTVSSKKKKPIKTtlSGKLGSTAATSKVEFRSIQAQVEQGHYKTPQEFDDHMQQLFV 1743
Cdd:cd05525    1 ARLAQVLKEICDAIITYKDSNGQSLAIPFINLPSKK--KNPDYYERITDPVDLSTIEKQILTGYYKTPEAFDSDMLKVFR 78

                         90       100
                 ....*....|....*....|....*...
gi 1335892  1744 EAKQQHGDDEGKEKALQSLKDSYEQQKI 1771
Cdd:cd05525   79 NAEKYYGRKSPIGRDVCRLRKAYYQAKH 106
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
1384-1512 3.20e-36

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 134.32  E-value: 3.20e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892  1384 KGWGVRTKLPIAKGTYILEYVGEVVTEKEFKQRMASiyLNDTHHYCLHLDGGLVIDGQRMGSDCRFVNHSCEPNCEmqkw 1463
Cdd:COG2940   16 HGRGVFATRDIPKGTLIGEYPGEVITWAEAERREPH--KEPLHTYLFELDDDGVIDGALGGNPARFINHSCDPNCE---- 89

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 1335892  1464 SVNGLSRMVLFAKRAIEEGEELTYDYNfsLFNPSEGQPCRCntPQCRGV 1512
Cdd:COG2940   90 ADEEDGRIFIVALRDIAAGEELTYDYG--LDYDEEEYPCRC--PNCRGT 134
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 1385-1490 4.41e-28

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 110.31  E-value: 4.41e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892    1385 GWGVRTKLPIAKGTYILEYVGE-VVTEKEFKQRMASIY----LNDTHHYCLHLD--GGLVIDG--QRMGSDCRFVNHSCE 1455
Cdd:pfam00856    1 GRGLFATEDIPKGEFIGEYVEVlLITKEEADKRELLYYdkleLRLWGPYLFTLDedSEYCIDAraLYYGNWARFINHSCD 80

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1335892    1456 PNCEMQKWSVNGLSRMVLFAKRAIEEGEELTYDYN 1490
Cdd:pfam00856   81 PNCEVRVVYVNGGPRIVIFALRDIKPGEELTIDYG 115
BAH smart00439
Bromo adjacent homology domain;
1915-2056 1.27e-27

Bromo adjacent homology domain;


Pssm-ID: 214664 [Multi-domain]  Cd Length: 121  Bit Score: 109.30  E-value: 1.27e-27
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892     1915 QVRQGDAVYVLRDIPIKDesgkvlptkkhtyetigaidyqeCDIFRVEHLWKNELGK--RFIFGQHFLRPHETFHEPSRR 1992
Cdd:smart00439    1 TISVGDFVLVEPDDADEP-----------------------YYIGRIEEIFETKKNSesKMVRVRWFYRPEETVLEKAAL 57

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1335892     1993 FYPNEVVRVSLYEVVPIELVIGPCWLLDRPTFSKGPPMECNDEDHCYICELRVDKTARFFSKAK 2056
Cdd:smart00439   58 FDKNEVFLSDEYDTVPLSDIIGKCNVLYKSDYPGLRPEGSIGEPDVFFCESAYDPEKGSFKKLP 121
PHD_ASH1L cd15548
PHD finger found in histone-lysine N-methyltransferase ASH1L; ASH1L, also termed ASH1-like ...
 1842-1884 4.99e-25

PHD finger found in histone-lysine N-methyltransferase ASH1L; ASH1L, also termed ASH1-like protein, or absent small and homeotic disks protein 1 homolog, or lysine N-methyltransferase 2H, is a protein belonging to the Trithorax family. It methylates Lys36 of histone H3 independently of transcriptional elongation to promote the establishment of Hox gene expression by counteracting Polycomb silencing. It can suppress interleukin-6 (IL-6), and tumor necrosis factor (TNF) production in Toll-like receptor (TLR)-triggered macrophages, and inflammatory autoimmune diseases by inducing the ubiquitin-editing enzyme A20. ASH1L contains an associated with SET domain (AWS), a SET domain, a post-SET domain, a bromodomain, a bromo-adjacent homology domain (BAH), and a plant homeodomain (PHD) finger.


Pssm-ID: 277023  Cd Length: 43  Bit Score: 99.08  E-value: 4.99e-25
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 1335892  1842 IRCICGLYKDEGLMIQCSKCMVWQHTECTKADIDADNYQCERC 1884
Cdd:cd15548    1 IRCICGLYKDEGLMIQCEKCMVWQHCDCMGVNDDVEHYLCEQC 43
AWS smart00570
associated with SET domains; subdomain of PRESET
 1324-1372 2.63e-16

associated with SET domains; subdomain of PRESET


Pssm-ID: 197795  Cd Length: 50  Bit Score: 74.74  E-value: 2.63e-16
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|.
gi 1335892     1324 DHPTCNCKNQ--GEKSCLDNCLNRMVYTECsPSNCPAGEKCRNQKIQRHAV 1372
Cdd:smart00570    1 DIMTCECKPTddDETACGSDCLNRMLFIEC-SSSCPCGSYCSNQRFQKRQY 50
BAH pfam01426
BAH domain; This domain has been called BAH (Bromo adjacent homology) domain and has also been ...
 1956-2054 8.09e-13

BAH domain; This domain has been called BAH (Bromo adjacent homology) domain and has also been called ELM1 and BAM (Bromo adjacent motif) domain. The function of this domain is unknown but may be involved in protein-protein interaction.


Pssm-ID: 460207  Cd Length: 120  Bit Score: 66.95  E-value: 8.09e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892    1956 CDIFRVEHLWKNELGKRF-IFGQHFLRPHETFHEPSRRFYPNEVVRVSLYEVVPIELVIGPCWLLDRPTFSKGPPMEcND 2034
Cdd:pfam01426   20 YYVARIEELFEDTKNGKKmVRVQWFYRPEETVHRAGKAFNKDELFLSDEEDDVPLSAIIGKCSVLHKSDLESLDPYK-IK 98

                           90       100
                   ....*....|....*....|
gi 1335892    2035 EDHCYICELRVDKTARFFSK 2054
Cdd:pfam01426   99 EPDDFFCELLYDPKTKSFKK 118
AWS pfam17907
AWS domain; This entry represents the AWS (associated with SET domain) domain. This is a zinc ...
 1335-1370 4.68e-12

AWS domain; This entry represents the AWS (associated with SET domain) domain. This is a zinc binding domain. The full AWS domain contains 8 cysteines. This entry represents the N-terminal part of the domain, with the C-terminal part interwoven with the SET domain.


Pssm-ID: 465559  Cd Length: 39  Bit Score: 62.06  E-value: 4.68e-12
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1335892    1335 EKSCLDNCLNRMVYTECSPSNCPAGEKCRNQKIQRH 1370
Cdd:pfam17907    4 PCGCGSDCINRMLFVECTPKTCPCGESCQNQRFQRK 39
PHD smart00249
PHD zinc finger; The plant homeodomain (PHD) finger is a C4HC3 zinc-finger-like motif found in ...
 1844-1884 3.63e-08

PHD zinc finger; The plant homeodomain (PHD) finger is a C4HC3 zinc-finger-like motif found in nuclear proteins thought to be involved in epigenetics and chromatin-mediated transcriptional regulation. The PHD finger binds two zinc ions using the so-called 'cross-brace' motif and is thus structurally related to the RING finger and the FYVE finger. It is not yet known if PHD fingers have a common molecular function. Several reports suggest that it can function as a protein-protein interacton domain and it was recently demonstrated that the PHD finger of p300 can cooperate with the adjacent BROMO domain in nucleosome binding in vitro. Other reports suggesting that the PHD finger is a ubiquitin ligase have been refuted as these domains were RING fingers misidentified as PHD fingers.


Pssm-ID: 214584 [Multi-domain]  Cd Length: 47  Bit Score: 51.44  E-value: 3.63e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1335892     1844 CICGLYKDEGLMIQCSKCMVWQHTEC----TKADIDADNYQCERC 1884
Cdd:smart00249    3 SVCGKPDDGGELLQCDGCDRWYHQTClgppLLEEEPDGKWYCPKC 47
PHD pfam00628
PHD-finger; PHD folds into an interleaved type of Zn-finger chelating 2 Zn ions in a similar ...
 1843-1887 5.79e-08

PHD-finger; PHD folds into an interleaved type of Zn-finger chelating 2 Zn ions in a similar manner to that of the RING and FYVE domains. Several PHD fingers have been identified as binding modules of methylated histone H3.


Pssm-ID: 425785 [Multi-domain]  Cd Length: 51  Bit Score: 50.95  E-value: 5.79e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1335892    1843 RC-ICGLYKDEGLMIQCSKCMVWQHTEC-----TKADIDADNYQCERCEPR 1887
Cdd:pfam00628    1 YCaVCGKSDDGGELVQCDGCDDWFHLAClgpplDPAEIPSGEWLCPECKPK 51
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1002-1265 3.34e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.55  E-value: 3.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892   1002 PNPPLDCERVPQAGEARetfvARTNQKAPRLSVVALE-RLQRPQTPAR-GRPRG-RKPKNREQAEAAPQPPPKSEPEIRP 1078
Cdd:PHA03247 2551 PPPPLPPAAPPAAPDRS----VPPPRPAPRPSEPAVTsRARRPDAPPQsARPRApVDDRGDPRGPAPPSPLPPDTHAPDP 2626

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892   1079 AKKRGR-QPKQPVLEEPPPTPPPQQKKNKMEP-NIRLP---DGIDPNTNFSCKIRLKRRKNLEAGTQPKKE--KPVQPVT 1151
Cdd:PHA03247 2627 PPPSPSpAANEPDPHPPPTVPPPERPRDDPAPgRVSRPrraRRLGRAAQASSPPQRPRRRAARPTVGSLTSlaDPPPPPP 2706

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892   1152 VEEIPPEIPVSQEEIDAEAEAKRVDSIPTEHDP----------LPASESHNPGPQDYASCSESSEDKA-STTSLRKLSKV 1220
Cdd:PHA03247 2707 TPEPAPHALVSATPLPPGPAAARQASPALPAAPappavpagpaTPGGPARPARPPTTAGPPAPAPPAApAAGPPRRLTRP 2786

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1335892   1221 KKTYLVAGLLSNHYKQSLMPPPAKVN-KKPGLEEQVGPASLLPPPP 1265
Cdd:PHA03247 2787 AVASLSESRESLPSPWDPADPPAAVLaPAAALPPAASPAGPLPPPT 2832
 
Name Accession Description Interval E-value
SET_ASH1L cd19174
SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ...
 1375-1515 1.35e-93

SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ASH1L (EC 2.1.1.43; also termed absent small and homeotic disks protein 1 homolog, KMT2H, or lysine N-methyltransferase 2H) acts as histone-lysine N-methyltransferase that specifically methylates 'Lys-36' of histone H3 (H3K36me). It plays important roles in development; heterozygous mutation of ASH1L is associated with severe intellectual disability (ID) and multiple congenital anomaly (MCA).


Pssm-ID: 380951 [Multi-domain]  Cd Length: 141  Bit Score: 298.82  E-value: 1.35e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892  1375 GVERFMTADKGWGVRTKLPIAKGTYILEYVGEVVTEKEFKQRMASIYLNDTHHYCLHLDGGLVIDGQRMGSDCRFVNHSC 1454
Cdd:cd19174    1 GLERFRTEDKGWGVRTKEPIKAGQFIIEYVGEVVSEQEFRRRMIEQYHNHSHHYCLNLDSGMVIDGYRMGNEARFVNHSC 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1335892  1455 EPNCEMQKWSVNGLSRMVLFAKRAIEEGEELTYDYNFSLFNPSEGQPCRCNTPQCRGVIGG 1515
Cdd:cd19174   81 DPNCEMQKWSVNGVYRIGLFALKDIPAGEELTYDYNFHSFNVEKQQPCKCGSPNCRGVIGG 141
SET_SETD2 cd19172
SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and ...
 1376-1514 9.68e-55

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and similar proteins; SETD2 (also termed HIF-1, huntingtin yeast partner B, huntingtin-interacting protein 1 (HIP-1), huntingtin-interacting protein B, lysine N-methyltransferase 3A or protein-lysine N-methyltransferase SETD2) acts as histone-lysine N-methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. It has been shown that methylation is a posttranslational modification of dynamic microtubules and that SETD2 methylates alpha-tubulin at lysine 40, the same lysine that is marked by acetylation on microtubules. Methylation of microtubules occurs during mitosis and cytokinesis and can be ablated by SETD2 deletion, which causes mitotic spindle and cytokinesis defects, micronuclei, and polyploidy.


Pssm-ID: 380949 [Multi-domain]  Cd Length: 142  Bit Score: 187.79  E-value: 9.68e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892  1376 VERFMTADKGWGVRTKLPIAKGTYILEYVGEVVTEKEFKQRMASiYLND--THHYCLHLDGGLVIDGQRMGSDCRFVNHS 1453
Cdd:cd19172    4 VEVFRTEKKGWGLRAAEDLPKGTFVIEYVGEVLDEKEFKRRMKE-YAREgnRHYYFMALKSDEIIDATKKGNLSRFINHS 82

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1335892  1454 CEPNCEMQKWSVNGLSRMVLFAKRAIEEGEELTYDYNFSLFNpSEGQPCRCNTPQCRGVIG 1514
Cdd:cd19172   83 CEPNCETQKWTVNGELRVGFFAKRDIPAGEELTFDYQFERYG-KEAQKCYCGSPNCRGYIG 142
SET_SETD2-like cd10531
SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), ...
 1376-1510 1.59e-52

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2), ASH1-like protein (ASH1L) and similar proteins; This family includes SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2) and ASH1-like protein (ASH1L), which function as histone-lysine N-methyltransferases. SETD2 specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. NSD2 shows histone H3 'Lys-27' (H3K27me) methyltransferase activity. ASH1L specifically methylates 'Lys-36' of histone H3 (H3K36me). The family also includes Arabidopsis thaliana ASH1-related protein 3 (ASHR3) and similar proteins.


Pssm-ID: 380929  Cd Length: 136  Bit Score: 181.30  E-value: 1.59e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892  1376 VERFMTADKGWGVRTKLPIAKGTYILEYVGEVVTEKEFKQRMASIY-LNDTHHYCLHLDGGLVIDGQRMGSDCRFVNHSC 1454
Cdd:cd10531    2 LELFRTEKKGWGVKAKEDIQKGEFIIEYVGEVIDKKEFKERLDEYEeLGKSNFYILSLSDDVVIDATRKGNLSRFINHSC 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 1335892  1455 EPNCEMQKWSVNGLSRMVLFAKRAIEEGEELTYDYNFSLFNpSEGQPCRCNTPQCR 1510
Cdd:cd10531   82 EPNCETQKWIVNGEYRIGIFALRDIPAGEELTFDYNFVNYN-EAKQVCLCGAQNCR 136
BAH_polybromo cd04717
BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human ...
 1913-2057 1.51e-51

BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human polybromo protein (BAF180) is a component of the SWI/SNF chromatin-remodeling complex PBAF. It is thought that polybromo participates in transcriptional regulation. Saccharomyces cerevisiae RSC1 and RSC2 are part of the 15-subunit nucleosome remodeling RSC complex. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the remodeling of chromatin. It is assumed that in most or all of these instances the BAH domain mediates protein-protein interactions.


Pssm-ID: 240068  Cd Length: 121  Bit Score: 177.78  E-value: 1.51e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892  1913 DLQVRQGDAVYVLRDIpikdesgkvlptkkhtyetigaiDYQECDIFRVEHLWKNELGKRFIFGQHFLRPHETFHEPSRR 1992
Cdd:cd04717    1 GLQYRVGDCVYVANPE-----------------------DPSKPIIFRIERLWKDEDGEKFFFGCWFYRPEETFHEPTRK 57

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1335892  1993 FYPNEVVRVSLYEVVPIELVIGPCWLLDRPTFSKGPPMECNDEDhCYICELRVDKTARFFSKAKA 2057
Cdd:cd04717   58 FYKNEVFKSPLYETVPVEEIVGKCAVMDVKDYIKGRPTEISEED-VYVCESRYNESAKSFKKIKT 121
SET_NSD cd19173
SET domain (including post-SET domain) found in nuclear SET domain-containing proteins, NSD1, ...
 1374-1514 1.48e-47

SET domain (including post-SET domain) found in nuclear SET domain-containing proteins, NSD1, NSD2, NSD3 and similar proteins; The nuclear receptor-binding SET Domain (NSD) family of histone H3 lysine 36 methyltransferases is comprised of NSD1, NSD2, and NSD3, which are primarily known to be involved in chromatin integrity and gene expression through mono-, di-, or tri-methylating lysine 36 of histone H3 (H3K36), respectively. NSD1 (EC 2.1.1.43; also termed histone-lysine N-methyltransferase H3 lysine-36 and H4 lysine-20 specific, androgen receptor coactivator 267 kDa protein (ARA267), androgen receptor-associated protein of 267 kDa, H3-K36-HMTase, H4-K20-HMTase, lysine N-methyltransferase 3B (KMT3B) or NR-binding SET domain-containing protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4. NSD2 (EC 2.1.1.43; also termed multiple myeloma SET domain-containing protein (MMSET), protein trithorax-5 (TRX5), or wolf-Hirschhorn syndrome candidate 1 protein (WHSC1)) acts as histone-lysine N-methyltransferase with histone H3 'Lys-27' (H3K27me) methyltransferase activity. NSD3 (EC 2.1.1.43; also termed protein whistle, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, Wolf-Hirschhorn syndrome candidate 1-like protein 1 (WHSC1L1), or WHSC1-like protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-4' and 'Lys-27' of histone H3.


Pssm-ID: 380950 [Multi-domain]  Cd Length: 142  Bit Score: 167.11  E-value: 1.48e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892  1374 PGVERFMTADKGWGVRTKLPIAKGTYILEYVGEVVTEKEFKQRMASIY-LNDTHHYCLHLDGGLVIDGQRMGSDCRFVNH 1452
Cdd:cd19173    2 PPTEPFKTGDRGWGLRTKRDIKKGDFVIEYVGELIDEEECRRRLKKAHeNNITNFYMLTLDKDRIIDAGPKGNLSRFMNH 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1335892  1453 SCEPNCEMQKWSVNGLSRMVLFAKRAIEEGEELTYDYNF-SLFNpsEGQPCRCNTPQCRGVIG 1514
Cdd:cd19173   82 SCQPNCETQKWTVNGDTRVGLFAVRDIPAGEELTFNYNLdCLGN--EKKVCRCGAPNCSGFLG 142
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 1376-1496 1.59e-43

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 154.80  E-value: 1.59e-43
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892     1376 VERFMTADKGWGVRTKLPIAKGTYILEYVGEVVTEKEFKQRMaSIYLNDT--HHYCLHLDGGLVIDGQRMGSDCRFVNHS 1453
Cdd:smart00317    3 LEVFKSPGKGWGVRATEDIPKGEFIGEYVGEIITSEEAEERP-KAYDTDGakAFYLFDIDSDLCIDARRKGNLARFINHS 81

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|...
gi 1335892     1454 CEPNCEMQKWSVNGLSRMVLFAKRAIEEGEELTYDYNFSLFNP 1496
Cdd:smart00317   82 CEPNCELLFVEVNGDDRIVIFALRDIKPGEELTIDYGSDYANE 124
SET_ASHR3-like cd19175
SET domain (including post-SET domain) found in Arabidopsis thaliana ASH1-related protein 3 ...
 1376-1514 2.82e-40

SET domain (including post-SET domain) found in Arabidopsis thaliana ASH1-related protein 3 (ASHR3) and similar proteins; This family includes Arabidopsis thaliana ASH1-related protein 3 (ASHR3, also termed protein SET DOMAIN GROUP 4 or protein stamen loss), ASH1 homolog 3 (ASHH3, also termed protein SET DOMAIN GROUP 7) and homolog 4 (ASHH4, also termed protein SET DOMAIN GROUP 24). They all function as histone-lysine N-methyltransferases (EC 2.1.1.43).


Pssm-ID: 380952 [Multi-domain]  Cd Length: 139  Bit Score: 146.41  E-value: 2.82e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892  1376 VERFMTADKGWGVRTKLPIAKGTYILEYVGEVVTEKEFKQRMASIYLN-DTHHYCLHLDGGLVIDGQRMGSDCRFVNHSC 1454
Cdd:cd19175    2 MKLVKTEKCGWGLVADEDINAGEFIIEYVGEVIDDKTCEERLWDMKHKgEKNFYMCEIDKDMVIDATFKGNLSRFINHSC 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892  1455 EPNCEMQKWSVNGLSRMVLFAKRAIEEGEELTYDYNFSLFNPSegQPCRCNTPQCRGVIG 1514
Cdd:cd19175   82 DPNCELQKWQVDGETRIGVFAIRDIKKGEELTYDYQFVQFGAD--QDCHCGSKNCRGKLG 139
Bromo_ASH1 cd05525
Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the ...
 1664-1771 9.27e-40

Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the trithorax-group in Drosophila melanogaster, an epigenetic transcriptional regulator of HOX genes. Drosophila ASH1 has been shown to methylate specific lysines in histones H3 and H4. Mammalian ASH1 has been shown to methylate histone H3. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99955 [Multi-domain]  Cd Length: 106  Bit Score: 143.30  E-value: 9.27e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892  1664 AKMAVVLRDICSAMETLKMSDLLTTVSSKKKKPIKTtlSGKLGSTAATSKVEFRSIQAQVEQGHYKTPQEFDDHMQQLFV 1743
Cdd:cd05525    1 ARLAQVLKEICDAIITYKDSNGQSLAIPFINLPSKK--KNPDYYERITDPVDLSTIEKQILTGYYKTPEAFDSDMLKVFR 78

                         90       100
                 ....*....|....*....|....*...
gi 1335892  1744 EAKQQHGDDEGKEKALQSLKDSYEQQKI 1771
Cdd:cd05525   79 NAEKYYGRKSPIGRDVCRLRKAYYQAKH 106
SET_SUV39H cd10542
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 1327-1513 1.70e-38

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homologs, SUV39H1, SUV39H2 and similar proteins; This family includes SUV39H1 (also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A, KMT1A, position-effect variegation 3-9 homolog, SUV39H, or Su(var)3-9 homolog 1) and SUV39H2 (also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B, KMT1B, or Su(var)3-9 homolog 2), both act as histone-lysine N-methyltransferases that specifically trimethylate 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. They mainly function in heterochromatin regions, thereby playing central roles in the establishment of constitutive heterochromatin at pericentric and telomere regions. Also included are Schizosaccharomyces pombe H3K9 methyltransferase Clr4 (SUV39H homolog) and Neurospora crassa DIM-5, both of which also methylate 'Lys-9' of histone H3.


Pssm-ID: 380940 [Multi-domain]  Cd Length: 245  Bit Score: 145.13  E-value: 1.70e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892  1327 TCNCKNQGEKSCLDNCLNRMVYT--------------ECSpSNCPAGEKCRNQKIQRHAVAPgVERFMTAD-KGWGVRTK 1391
Cdd:cd10542   28 TEDCHNNNPTCCPAESGVKFAYDkqgrlrlppgtpiyECN-SRCKCGPDCPNRVVQRGRKVP-LCIFRTSNgRGWGVKTL 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892  1392 LPIAKGTYILEYVGEVVTEKEFKQRmASIYLNDTHHYCLHLDGG-----LVIDGQRMGSDCRFVNHSCEPNceMQKWSVN 1466
Cdd:cd10542  106 EDIKKGTFVMEYVGEIITSEEAERR-GKIYDANGRTYLFDLDYNdddceYTVDAAYYGNISHFINHSCDPN--LAVYAVW 182

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1335892  1467 G------LSRMVLFAKRAIEEGEELTYDYNFSL-FNPSEGQ---------PCRCNTPQCRGVI 1513
Cdd:cd10542  183 InhldprLPRIAFFAKRDIKAGEELTFDYLMTGtGGSSESTipkpkdvrvPCLCGSKNCRKYL 245
SET_NSD2 cd19211
SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) ...
 1374-1514 4.94e-37

SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins; NSD2 (EC 2.1.1.43; also termed multiple myeloma SET domain-containing protein (MMSET), protein trithorax-5 (TRX5), or wolf-Hirschhorn syndrome candidate 1 protein (WHSC1)) acts as histone-lysine N-methyltransferase with histone H3 'Lys-36' (H3K36me) methyltransferase activity. NSD2 has been shown to mediate di- and trimethylation of H3K36 and dimethylation of H4K20 in different systems, and has been characterized as a transcriptional repressor interacting with histone deacetylase HDAC1 and histone demethylase LSD1. NSD2 mediates constitutive NF-kappaB signaling for cancer cell proliferation, survival and tumor growth. It is highly overexpressed in several types of human cancers, including small-cell lung cancers, neuroblastoma, carcinomas of stomach and colon, and bladder cancers, and its overexpression tends to be associated with tumor aggressiveness. WHSC1 is frequently deleted in Wolf-Hirschhorn syndrome (WHS).


Pssm-ID: 380988 [Multi-domain]  Cd Length: 142  Bit Score: 137.04  E-value: 4.94e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892  1374 PGVERFMTADKGWGVRTKLPIAKGTYILEYVGEVVTEKEFKQRMASIYLND-THHYCLHLDGGLVIDGQRMGSDCRFVNH 1452
Cdd:cd19211    2 PETKIIKTEGKGWGLIAKRDIKKGEFVNEYVGELIDEEECMARIKHAHENDiTHFYMLTIDKDRIIDAGPKGNYSRFMNH 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1335892  1453 SCEPNCEMQKWSVNGLSRMVLFAKRAIEEGEELTYDYNFSLFNpSEGQPCRCNTPQCRGVIG 1514
Cdd:cd19211   82 SCQPNCETQKWTVNGDTRVGLFAVCDIPAGTELTFNYNLDCLG-NEKTVCRCGAPNCSGFLG 142
SET_NSD1 cd19210
SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing ...
 1374-1514 1.39e-36

SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins; NSD1 (EC 2.1.1.43; also termed Histone-lysine N-methyltransferase H3 lysine-36 and H4 lysine-20 specific, androgen receptor coactivator 267 kDa protein (ARA267), androgen receptor-associated protein of 267 kDa, H3-K36-HMTase, H4-K20-HMTase, lysine N-methyltransferase 3B (KMT3B), or NR-binding SET domain-containing protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4. NSD1 is altered in approximately 10% of head and neck cancer patients with 55% decrease in risk of death in NSD1-mutated versus non-mutated patients; its disruption promotes favorable chemotherapeutic responses linked to hypomethylation.


Pssm-ID: 380987 [Multi-domain]  Cd Length: 142  Bit Score: 135.83  E-value: 1.39e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892  1374 PGVERFMTADKGWGVRTKLPIAKGTYILEYVGEVVTEKEFKQRMASIYLND-THHYCLHLDGGLVIDGQRMGSDCRFVNH 1452
Cdd:cd19210    2 PEVEIFRTLGRGWGLRCKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDiTNFYMLTLDKDRIIDAGPKGNYARFMNH 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1335892  1453 SCEPNCEMQKWSVNGLSRMVLFAKRAIEEGEELTYDYNFSLFNPSEgQPCRCNTPQCRGVIG 1514
Cdd:cd19210   82 CCQPNCETQKWTVNGDTRVGLFALCDIKAGTELTFNYNLECLGNGK-TVCKCGAPNCSGFLG 142
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
1384-1512 3.20e-36

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 134.32  E-value: 3.20e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892  1384 KGWGVRTKLPIAKGTYILEYVGEVVTEKEFKQRMASiyLNDTHHYCLHLDGGLVIDGQRMGSDCRFVNHSCEPNCEmqkw 1463
Cdd:COG2940   16 HGRGVFATRDIPKGTLIGEYPGEVITWAEAERREPH--KEPLHTYLFELDDDGVIDGALGGNPARFINHSCDPNCE---- 89

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 1335892  1464 SVNGLSRMVLFAKRAIEEGEELTYDYNfsLFNPSEGQPCRCntPQCRGV 1512
Cdd:COG2940   90 ADEEDGRIFIVALRDIAAGEELTYDYG--LDYDEEEYPCRC--PNCRGT 134
SET_NSD3 cd19212
SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing ...
 1374-1514 5.96e-35

SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 3 (NSD3) and similar proteins; NSD3 (EC 2.1.1.43; also termed protein whistle, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, Wolf-Hirschhorn syndrome candidate 1-like protein 1 (WHSC1L1), or WHSC1-like protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. NSD3 is amplified and overexpressed in multiple cancer types, including acute myeloid leukemia (AML), breast, lung, pancreatic and bladder cancers, as well as squamous cell carcinoma of the head and neck (SCCHN). NSD3 contributes to tumorigenesis by interacting with bromodomain-containing protein 4 (BRD4), the bromodomain and extraterminal (BET) protein, which is a potential therapeutic target in acute myeloid leukemia (AML). NSD3 is amplified in primary tumors and cell lines from breast carcinoma, and can promote the cell viability of small-cell lung cancer and pancreatic ductal adenocarcinoma. High NSD3 expression is implicated in poor grade and heavy smoking history in SCCHN. Thus, NSD3 may serve as a potential druggable target for selective cancer therapy.


Pssm-ID: 380989 [Multi-domain]  Cd Length: 142  Bit Score: 131.20  E-value: 5.96e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892  1374 PGVERFMTADKGWGVRTKLPIAKGTYILEYVGEVVTEKEFKQRMASIYLND-THHYCLHLDGGLVIDGQRMGSDCRFVNH 1452
Cdd:cd19212    2 PDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSvTNFYMLTVTKDRIIDAGPKGNYSRFMNH 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1335892  1453 SCEPNCEMQKWSVNGLSRMVLFAKRAIEEGEELTYDYNFSLFNPSEGQpCRCNTPQCRGVIG 1514
Cdd:cd19212   82 SCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYNLDCLGNGRTE-CHCGADNCSGFLG 142
SET_SETD1-like cd10518
SET domain (including post-SET domain) found in SET domain-containing proteins (SETD1A/SETD1B), ...
 1385-1510 8.06e-33

SET domain (including post-SET domain) found in SET domain-containing proteins (SETD1A/SETD1B), histone-lysine N-methyltransferases (KMT2A/KMT2B/KMT2C/KMT2D) and similar proteins; This family includes SET domain-containing protein 1A (SETD1A), 1B (SETD1B), as well as histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B), 2C (KMT2C), 2D (KMT2D). These proteins are histone-lysine N-methyltransferases (EC 2.1.1.43) that specifically methylate 'Lys-4' of histone H3 (H3K4me).


Pssm-ID: 380916  Cd Length: 150  Bit Score: 125.40  E-value: 8.06e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892  1385 GWGVRTKLPIAKGTYILEYVGEVVT-------EKEFKQRMAsiylNDThhYCLHLDGGLVIDGQRMGSDCRFVNHSCEPN 1457
Cdd:cd10518   25 GWGLFAKRPIAAGEMVIEYVGEVIRpivadkrEKRYDEEGG----GGT--YMFRIDEDLVIDATKKGNIARFINHSCDPN 98

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 1335892  1458 CEMQKWSVNGLSRMVLFAKRAIEEGEELTYDYNFslfnPSEGQ---PCRCNTPQCR 1510
Cdd:cd10518   99 CYAKIITVDGEKHIVIFAKRDIAPGEELTYDYKF----PIEDEekiPCLCGAPNCR 150
SET_SETMAR cd10544
SET domain (including pre-SET and post-SET domains) found in SET domain and mariner ...
 1326-1511 8.65e-33

SET domain (including pre-SET and post-SET domains) found in SET domain and mariner transposase fusion protein (SETMAR) and similar proteins; SETMAR (also termed metnase) is a DNA-binding protein that is indirectly recruited to sites of DNA damage through protein-protein interactions. It has a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity. SETMAR also acts as a histone-lysine N-methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3. It specifically mediates dimethylation of H3 'Lys-36' at sites of DNA double-strand break and may recruit proteins required for efficient DSB repair through non-homologous end-joining.


Pssm-ID: 380942 [Multi-domain]  Cd Length: 254  Bit Score: 128.96  E-value: 8.65e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892  1326 PTCNCKNQgekSCLDN---CLNRMVYT-------------------ECSpSNCPAGEKCRNQKIQrHAVAPGVERFMTAD 1383
Cdd:cd10544   25 PGCDCKTS---SCEPEtcsCLRKYGPNydddgclldfdgkysgpvfECN-SMCKCSESCQNRVVQ-NGLQFKLQVFKTPK 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892  1384 KGWGVRTKLPIAKGTYILEYVGEVVTEKEFKQRMASIYLNDThHYCL----HLDGGLV----IDGQRMGSDCRFVNHSCE 1455
Cdd:cd10544  100 KGWGLRTLEFIPKGRFVCEYAGEVIGFEEARRRTKSQTKGDM-NYIIvlreHLSSGKVletfVDPTYIGNIGRFLNHSCE 178

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1335892  1456 PNCEMQKWSVNGL-SRMVLFAKRAIEEGEELTYDYNFSLFN------------PSEGQPCRCNTPQCRG 1511
Cdd:cd10544  179 PNLFMVPVRVDSMvPKLALFAARDIVAGEELSFDYSGEFSNsvesvtlarqdeSKSRKPCLCGAENCRG 247
SET_SETDB-like cd10538
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) ...
 1303-1490 2.20e-32

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2, and similar proteins; The family includes SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2. SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis. SUV39H1 (also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A, KMT1A, position-effect variegation 3-9 homolog, SUV39H, or Su(var)3-9 homolog 1) and SUV39H2 (also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B, KMT1B, or Su(var)3-9 homolog 2), both act as histone-lysine N-methyltransferases that specifically trimethylate 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. They mainly function in heterochromatin regions, thereby playing central roles in the establishment of constitutive heterochromatin at pericentric and telomere regions. EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, lysine N-methyltransferase 1D, or KMT1D) and EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C, KMT1C, or protein G9a), both act as histone-lysine N-methyltransferases that specifically mono- and dimethylate 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. This family also includes the pre-SET domain, which is found in a number of histone methyltransferases (HMTase), N-terminal to the SET domain. Pre-SET domain is a zinc binding motif which contains 9 conserved cysteines that coordinate three zinc ions. It is thought that this region plays a structural role in stabilizing SET domains. Most family members, except for Arabidopsis thaliana SUVH9, contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380936 [Multi-domain]  Cd Length: 217  Bit Score: 126.33  E-value: 2.20e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892  1303 NYRKIRTNVYAESVRPNLAGFDHPTCNCK---NQGEKSCLDNCLNRMVYT---------------ECSPSnCPAGEKCRN 1364
Cdd:cd10538    2 SFTYIKDNIVGKNVQPFSNIIDSVGCKCKddcLDSKCACAAESDGIFAYTkngllrlnnspppifECNSK-CSCDDDCKN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892  1365 QKIQRHAVAPgVERFMTADKGWGVRTKLPIAKGTYILEYVGEVVTEKEFKQRMaSIYLNDTHHYCLHLDG---------G 1435
Cdd:cd10538   81 RVVQRGLQAR-LQVFRTSKKGWGVRSLEFIPKGSFVCEYVGEVITTSEADRRG-KIYDKSGGSYLFDLDEfsdsdgdgeE 158

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 1335892  1436 LVIDGQRMGSDCRFVNHSCEPNCEMQKWSVNGLSRM----VLFAKRAIEEGEELTYDYN 1490
Cdd:cd10538  159 LCVDATFCGNVSRFINHSCDPNLFPFNVVIDHDDLRypriALFATRDILPGEELTFDYG 217
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 1385-1490 4.41e-28

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 110.31  E-value: 4.41e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892    1385 GWGVRTKLPIAKGTYILEYVGE-VVTEKEFKQRMASIY----LNDTHHYCLHLD--GGLVIDG--QRMGSDCRFVNHSCE 1455
Cdd:pfam00856    1 GRGLFATEDIPKGEFIGEYVEVlLITKEEADKRELLYYdkleLRLWGPYLFTLDedSEYCIDAraLYYGNWARFINHSCD 80

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1335892    1456 PNCEMQKWSVNGLSRMVLFAKRAIEEGEELTYDYN 1490
Cdd:pfam00856   81 PNCEVRVVYVNGGPRIVIFALRDIKPGEELTIDYG 115
BAH smart00439
Bromo adjacent homology domain;
1915-2056 1.27e-27

Bromo adjacent homology domain;


Pssm-ID: 214664 [Multi-domain]  Cd Length: 121  Bit Score: 109.30  E-value: 1.27e-27
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892     1915 QVRQGDAVYVLRDIPIKDesgkvlptkkhtyetigaidyqeCDIFRVEHLWKNELGK--RFIFGQHFLRPHETFHEPSRR 1992
Cdd:smart00439    1 TISVGDFVLVEPDDADEP-----------------------YYIGRIEEIFETKKNSesKMVRVRWFYRPEETVLEKAAL 57

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1335892     1993 FYPNEVVRVSLYEVVPIELVIGPCWLLDRPTFSKGPPMECNDEDHCYICELRVDKTARFFSKAK 2056
Cdd:smart00439   58 FDKNEVFLSDEYDTVPLSDIIGKCNVLYKSDYPGLRPEGSIGEPDVFFCESAYDPEKGSFKKLP 121
SET_SETD1 cd19169
SET domain (including post-SET domain) found in SET domain-containing protein 1 (SETD1) and ...
 1385-1510 5.07e-27

SET domain (including post-SET domain) found in SET domain-containing protein 1 (SETD1) and similar proteins; This family includes SET domain-containing protein 1A (SETD1A) and SET domain-containing protein 1B (SETD1B). These proteins are histone-lysine N-methyltransferases that specifically methylate 'Lys-4' of histone H3 (H3K4me) when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated.


Pssm-ID: 380946  Cd Length: 148  Bit Score: 108.58  E-value: 5.07e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892  1385 GWGVRTKLPIAKGTYILEYVGEVVT-------EKEFKQR-MASIYLndthhycLHLDGGLVIDGQRMGSDCRFVNHSCEP 1456
Cdd:cd19169   24 DWGLFALEPIAADEMVIEYVGQVIRqsvaderEKRYEAIgIGSSYL-------FRVDDDTIIDATKCGNLARFINHSCNP 96

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 1335892  1457 NCEMQKWSVNGLSRMVLFAKRAIEEGEELTYDYNFSLfnPSEGQPCRCNTPQCR 1510
Cdd:cd19169   97 NCYAKIITVESQKKIVIYSKRPIAVNEEITYDYKFPI--EDEKIPCLCGAPQCR 148
SET_EZH cd10519
SET domain found in enhancer of zeste homolog 1 (EZH1), zeste homolog 2 (EZH2) and similar ...
 1385-1489 8.12e-27

SET domain found in enhancer of zeste homolog 1 (EZH1), zeste homolog 2 (EZH2) and similar proteins; The family includes EZH1 and EZH2. EZH1 (EC 2.1.1.43; also termed ENX-2, or histone-lysine N-methyltransferase EZH1) is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. EZH2 (EC 2.1.1.43; also termed lysine N-methyltransferase 6, ENX-1, or histone-lysine N-methyltransferase EZH2) is a catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Both, EZH1 and EZH2, can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively.


Pssm-ID: 380917  Cd Length: 117  Bit Score: 106.94  E-value: 8.12e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892  1385 GWGVRTKLPIAKGTYILEYVGEVVTEKEFKQRmASIYLNDTHHYCLHLDGGLVIDGQRMGSDCRFVNHSCEPNCEMQKWS 1464
Cdd:cd10519   12 GWGLFLKEPIKKDEFIGEYTGELISQDEADRR-GKIYDKYNSSYLFNLNDQFVVDATRKGNKIRFANHSSNPNCYAKVMM 90

                         90       100
                 ....*....|....*....|....*
gi 1335892  1465 VNGLSRMVLFAKRAIEEGEELTYDY 1489
Cdd:cd10519   91 VNGDHRIGIFAKRDIEAGEELFFDY 115
SET_EHMT cd10543
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 1328-1510 3.28e-25

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase EHMT1, EHMT2 and similar proteins; This family includes EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, lysine N-methyltransferase 1D, or KMT1D) and EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C, KMT1C, or protein G9a), both act as histone-lysine N-methyltransferases that specifically mono- and dimethylate 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380941 [Multi-domain]  Cd Length: 231  Bit Score: 106.27  E-value: 3.28e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892  1328 CNCKNQGEK------SCL---DNCLNRMVYTECSPSnCPAGEKCRNQKIQrHAVAPGVERFMTADKGWGVRTKLPIAKGT 1398
Cdd:cd10543   38 CVCGRLSVRcwydkeGRLlpdFNKLDPPLIFECNRA-CSCWRNCRNRVVQ-NGIRYRLQLFRTRGMGWGVRALQDIPKGT 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892  1399 YILEYVGEVVTEKEFKQRMASIYL-----NDTHHYClhldgglvIDGQRMGSDCRFVNHSCEPNC-------EMQKWSvn 1466
Cdd:cd10543  116 FVCEYIGELISDSEADSREDDSYLfdldnKDGETYC--------IDARRYGNISRFINHLCEPNLipvrvfvEHQDLR-- 185

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 1335892  1467 gLSRMVLFAKRAIEEGEELTYDYN----------FSlfnpsegqpCRCNTPQCR 1510
Cdd:cd10543  186 -FPRIAFFASRDIKAGEELGFDYGekfwrikgkyFT---------CRCGSPKCK 229
PHD_ASH1L cd15548
PHD finger found in histone-lysine N-methyltransferase ASH1L; ASH1L, also termed ASH1-like ...
 1842-1884 4.99e-25

PHD finger found in histone-lysine N-methyltransferase ASH1L; ASH1L, also termed ASH1-like protein, or absent small and homeotic disks protein 1 homolog, or lysine N-methyltransferase 2H, is a protein belonging to the Trithorax family. It methylates Lys36 of histone H3 independently of transcriptional elongation to promote the establishment of Hox gene expression by counteracting Polycomb silencing. It can suppress interleukin-6 (IL-6), and tumor necrosis factor (TNF) production in Toll-like receptor (TLR)-triggered macrophages, and inflammatory autoimmune diseases by inducing the ubiquitin-editing enzyme A20. ASH1L contains an associated with SET domain (AWS), a SET domain, a post-SET domain, a bromodomain, a bromo-adjacent homology domain (BAH), and a plant homeodomain (PHD) finger.


Pssm-ID: 277023  Cd Length: 43  Bit Score: 99.08  E-value: 4.99e-25
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 1335892  1842 IRCICGLYKDEGLMIQCSKCMVWQHTECTKADIDADNYQCERC 1884
Cdd:cd15548    1 IRCICGLYKDEGLMIQCEKCMVWQHCDCMGVNDDVEHYLCEQC 43
SET_SET1 cd20072
SET domain (including post-SET domain) found in catalytic component of the Saccharomyces ...
 1386-1510 3.66e-24

SET domain (including post-SET domain) found in catalytic component of the Saccharomyces cerevisiae COMPASS complex and similar proteins; The family contains mostly fungal SET domains, including SET1 found in the catalytic component of the Saccharomyces cerevisiae COMPASS (complex of proteins associated with Set1). SET1 is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me), when part of the SET1 histone methyltransferase (HMT) complex. The activity of this catalytic domain is established through forming a complex with a set of core proteins; it is extensively contacted by Cps60 (Bre2), Cps50 (Swd1), and Cps30 (Swd3).


Pssm-ID: 380998  Cd Length: 148  Bit Score: 100.58  E-value: 3.66e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892  1386 WGVRTKLPIAKGTYILEYVGEVVT-------EKEF-KQRMASIYLndthhycLHLDGGLVIDGQRMGSDCRFVNHSCEPN 1457
Cdd:cd20072   25 WGLYAMENISAKDMVIEYVGEVIRqqvaderEKRYlRQGIGSSYL-------FRIDDDTVVDATKKGNIARFINHCCDPN 97

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 1335892  1458 CEMQKWSVNGLSRMVLFAKRAIEEGEELTYDYNFslfnPSEGQ--PCRCNTPQCR 1510
Cdd:cd20072   98 CTAKIIKVEGEKRIVIYAKRDIAAGEELTYDYKF----PREEDkiPCLCGAPNCR 148
SET_KMT2A_2B cd19170
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), ...
 1385-1511 3.71e-24

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B) and similar proteins; This family includes KMT2A and KMT2B. Both KMT2A (also termed ALL-1 or CXXC7 or MLL or MLL1 or TRX1 or HRX) and KMT2B (also termed MLL4 or TRX2) act as histone methyltransferases that methylate 'Lys-4' of histone H3 (H3K4me).


Pssm-ID: 380947 [Multi-domain]  Cd Length: 152  Bit Score: 100.54  E-value: 3.71e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892  1385 GWGVRTKLPIAKGTYILEYVGEVV-------TEKEFKQRMASIYLndthhycLHLDGGLVIDGQRMGSDCRFVNHSCEPN 1457
Cdd:cd19170   25 GRGLFCKRNIDAGEMVIEYAGEVIrsvltdkREKYYESKGIGCYM-------FRIDDDEVVDATMHGNAARFINHSCEPN 97

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 1335892  1458 CEMQKWSVNGLSRMVLFAKRAIEEGEELTYDYNFSLfnPSEGQPCRCNTPQCRG 1511
Cdd:cd19170   98 CYSRVVNIDGKKHIVIFALRRILRGEELTYDYKFPI--EDVKIPCTCGSKKCRK 149
SET_SETDB1 cd10517
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) ...
 1338-1511 1.26e-23

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and similar proteins; SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes.


Pssm-ID: 380915 [Multi-domain]  Cd Length: 288  Bit Score: 103.14  E-value: 1.26e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892  1338 CLDNCLNRMVYtECSpSNCPAGEKCRNQKIQrHAVAPGVERFMTADKGWGVRTKLPIAKGTYILEYVGEVVTEKEFK--- 1414
Cdd:cd10517   96 RLMEKLPTGVY-ECN-SRCKCDKRCYNRVVQ-NGLQVRLQVFKTEKKGWGIRCLDDIPKGSFVCIYAGQILTEDEANeeg 172

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892  1415 QRMASIYL-----------------NDTHHYCLhldgglVIDGQRMGSDCRFVNHSCEPNCEMQKWSVNG----LSRMVL 1473
Cdd:cd10517  173 LQYGDEYFaeldyievveklkegyeSDVEEHCY------IIDAKSEGNLGRYLNHSCSPNLFVQNVFVDThdlrFPWVAF 246

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 1335892  1474 FAKRAIEEGEELTYDYNFSLFN-PSEGQPCRCNTPQCRG 1511
Cdd:cd10517  247 FASRYIRAGTELTWDYNYEVGSvPGKVLYCYCGSSNCRG 285
SET_KMT2C_2D cd19171
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), ...
 1384-1511 2.08e-23

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins; This family includes KMT2C and KMT2D. Both, KMT2C (also termed HALR or MLL3) and KMT2D (also termed ALR or MLL2), act as histone methyltransferases that methylate 'Lys-4' of histone H3 (H3K4me). They are subunits of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation.


Pssm-ID: 380948 [Multi-domain]  Cd Length: 153  Bit Score: 98.66  E-value: 2.08e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892  1384 KGWGVRTKLPIAKGTYILEYVGEVVtEKEFKQRMASIYLNDTHH-YCLHLDGGLVIDGQRMGSDCRFVNHSCEPNCEMQK 1462
Cdd:cd19171   24 QGLGLYAARDIEKHTMVIEYIGEII-RNEVANRREKIYESQNRGiYMFRIDNDWVIDATMTGGPARYINHSCNPNCVAEV 102

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 1335892  1463 WSVNGLSRMVLFAKRAIEEGEELTYDYNFSLFNPSEGQPCRCNTPQCRG 1511
Cdd:cd19171  103 VTFDKEKKIIIISNRRIAKGEELTYDYKFDFEDDQHKIPCLCGAPNCRK 151
SET_SUV39H1 cd10525
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 1350-1510 2.48e-23

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 1 (SUV39H1) and similar proteins; SUV39H1 (EC 2.1.1.43; also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A (KMT1A), position-effect variegation 3-9 homolog (SUV39H), or Su(var)3-9 homolog 1) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. It mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions.


Pssm-ID: 380923 [Multi-domain]  Cd Length: 255  Bit Score: 101.51  E-value: 2.48e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892  1350 ECSpSNCPAGEKCRNQKIQRhavapGVER----FMTAD-KGWGVRTKLPIAKGTYILEYVGEVVTEKEFKQRmASIYLND 1424
Cdd:cd10525   64 ECN-SRCRCGPDCPNRVVQK-----GIQYdlciFRTDNgRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERR-GQIYDRQ 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892  1425 THHYCLHLD---GGLVIDGQRMGSDCRFVNHSCEPNCEMQKWSVNGLS----RMVLFAKRAIEEGEELTYDYNFSLfNPS 1497
Cdd:cd10525  137 GATYLFDLDyveDVYTVDAAYYGNISHFVNHSCDPNLQVYNVFIDNLDerlpRIALFATRTIRAGEELTFDYNMQV-DPV 215

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 1335892  1498 ----------------EGQP-------CRCNTPQCR 1510
Cdd:cd10525  216 daestkmdsnfglaglPGSPkkrvrieCKCGVRSCR 251
SET_AtSUVH-like cd10545
SET domain found in Arabidopsis thaliana histone H3-K9 methyltransferases (SUVHs) and similar ...
 1346-1491 2.50e-23

SET domain found in Arabidopsis thaliana histone H3-K9 methyltransferases (SUVHs) and similar proteins; Arabidopsis thaliana SUVH protein (also termed suppressor of variegation 3-9 homolog protein) is a histone-lysine N-methyltransferase that methylates 'Lys-9' of histone H3. H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression. Some family members contain a post-SET domain which binds a Zn2+ ion. Most family members, except for Arabidopsis thaliana SUVH9, contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380943 [Multi-domain]  Cd Length: 232  Bit Score: 100.94  E-value: 2.50e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892  1346 MVYtECSPsNCPAGEKCRNQKIQrHAVAPGVERFMTADKGWGVRTKLPIAKGTYILEYVGEVVTEKEFKQRMAS-IYLND 1424
Cdd:cd10545   61 AIY-ECGP-LCKCPPSCYNRVTQ-KGLRYRLEVFKTAERGWGVRSWDSIPAGSFICEYVGELLDTSEADTRSGNdDYLFD 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892  1425 -THHYCLHLDGG-----------------------LVIDGQRMGSDCRFVNHSCEPNCEMQKWSVNG----LSRMVLFAK 1476
Cdd:cd10545  138 iDNRQTNRGWDGgqrldvgmsdgerssaedeesseFTIDAGSFGNVARFINHSCSPNLFVQCVLYDHndlrLPRVMLFAA 217

                        170
                 ....*....|....*
gi 1335892  1477 RAIEEGEELTYDYNF 1491
Cdd:cd10545  218 DNIPPLQELTYDYGY 232
SET_SUV39H_Clr4-like cd20073
SET domain (including pre-SET and post-SET domains) found in of Schizosaccharomyces pombe H3K9 ...
 1328-1511 3.82e-23

SET domain (including pre-SET and post-SET domains) found in of Schizosaccharomyces pombe H3K9 methyltransferase Clr4, and similar proteins; This subfamily contains fission yeast Schizosaccharomyces pombe H3K9 methyltransferase Clr4 (also known as Suv39h), the sole homolog of the mammalian SUV39H1 and SUV39H2 enzymes, that has a critical role in preventing aberrant heterochromatin formation. It is known to di- and tri-methylate Lys-9 of histone H3, a central heterochromatic histone modification, with its specificity profile most similar to that of the human SUV39H2 homolog.


Pssm-ID: 380999 [Multi-domain]  Cd Length: 259  Bit Score: 101.11  E-value: 3.82e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892  1328 CNCKNQGEKSCLDN---------------CLNRMVYTECSpSNCPAGEKCRNQKIQRHAVAPgVERFMTADKGWGVRTKL 1392
Cdd:cd20073   34 CDLNNPGSCQCLEDsneksfaydeygrvrANTGSIIYECN-ENCDCGINCPNRVVQRGRKLP-LEIFKTKHKGWGLRCPR 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892  1393 PIAKGTYILEYVGEVVTEKEFKQRmASIYLNDTHHYCLHLD-------GGLVIDGQRMGSDCRFVNHSCEPNCEMQKWSV 1465
Cdd:cd20073  112 FIKAGTFIGVYLGEVITQSEAEIR-GKKYDNVGVTYLFDLDlfedqvdEYYTVDAQYCGDVTRFINHSCDPNLAIYSVLR 190

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1335892  1466 N-GLSR---MVLFAKRAIEEGEELTYDY---------NFSLFNPSEG-------QPCRCNTPQCRG 1511
Cdd:cd20073  191 DkSDSKiydLAFFAIKDIPALEELTFDYsgrnnfdqlGFIGNRSNSKyinlknkRPCYCGSANCRG 256
SET_KMT2A cd19206
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A) ...
 1365-1510 1.81e-22

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A) and similar proteins; KMT2A (EC2.1.1.43; also termed lysine N-methyltransferase 2A, ALL-1, CXXC-type zinc finger protein 7 (CXXC7), myeloid/lymphoid or mixed-lineage leukemia (MLL), myeloid/lymphoid or mixed-lineage leukemia protein 1 (MLL1), trithorax-like protein (TRX1), or zinc finger protein HRX) acts as a histone methyltransferase that plays an essential role in early development and hematopoiesis. It is a catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac).


Pssm-ID: 380983 [Multi-domain]  Cd Length: 154  Bit Score: 95.86  E-value: 1.81e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892  1365 QKIQRHAVapGVERfmTADKGWGVRTKLPIAKGTYILEYVGEVVTEKEFKQRMASIYLNDTHHYCLHLDGGLVIDGQRMG 1444
Cdd:cd19206    9 KKTSKEAV--GVYR--SPIHGRGLFCKRNIDAGEMVIEYSGNVIRSILTDKREKYYDSKGIGCYMFRIDDSEVVDATMHG 84

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1335892  1445 SDCRFVNHSCEPNCEMQKWSVNGLSRMVLFAKRAIEEGEELTYDYNFSLFNPSEGQPCRCNTPQCR 1510
Cdd:cd19206   85 NAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCR 150
SET_SETD8 cd10528
SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins; SETD8 (EC 2. ...
 1374-1489 1.84e-22

SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins; SETD8 (EC 2.1.1.43; also termed N-lysine methyltransferase KMT5A, H4-K20-HMTase KMT5A, lysine N-methyltransferase 5A, lysine-specific methylase 5A, PR/SET domain-containing protein 07, PR-Set7 or PR/SET07) is a nucleosomal histone-lysine N-methyltransferase that specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). It plays a central role in the silencing of euchromatic genes.


Pssm-ID: 380926 [Multi-domain]  Cd Length: 141  Bit Score: 95.34  E-value: 1.84e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892  1374 PGVERFMTADKGWGVRTKLPIAKGTYILEYVGEVVTEKEFKQRMASIYLNDT--------HH----YClhldgglvIDGQ 1441
Cdd:cd10528   17 EGLKVIEIDGKGRGVIATRPFEKGDFVVEYHGDLITITEAKKREALYAKDPStgcymyyfQYkgktYC--------VDAT 88

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 1335892  1442 ----RMGsdcRFVNHSC-EPNCEMQKWSVNGLSRMVLFAKRAIEEGEELTYDY 1489
Cdd:cd10528   89 kesgRLG---RLINHSKkKPNLKTKLLVIDGVPHLILVAKRDIKPGEELLYDY 138
SET_EZH2 cd19218
SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins; EZH2 (EC 2.1.1.43) ...
 1385-1491 3.37e-22

SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins; EZH2 (EC 2.1.1.43), also termed lysine N-methyltransferase 6, or ENX-1, or histone-lysine N-methyltransferase EZH2, is a catalytic subunit of the polycomb repressive complex 2 (PRC2)/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. It can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. PRC2 is involved in several cancers; EZH2 is overexpressed in breast, liver and prostate cancer, while point mutations in EZH2 alter the substrate preference and product specificity of PRC2 in Non-Hodgkin lymphomas (NHLs). Thus, PRC2 is a popular target for cancer therapeutics.


Pssm-ID: 380995  Cd Length: 120  Bit Score: 93.82  E-value: 3.37e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892  1385 GWGVRTKLPIAKGTYILEYVGEVVTEKEFKQRmASIYLNDTHHYCLHLDGGLVIDGQRMGSDCRFVNHSCEPNCEMQKWS 1464
Cdd:cd19218   15 GWGIFIKDPVQKNEFISEYCGEIISQDEADRR-GKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMM 93

                         90       100
                 ....*....|....*....|....*..
gi 1335892  1465 VNGLSRMVLFAKRAIEEGEELTYDYNF 1491
Cdd:cd19218   94 VNGDHRIGIFAKRAIQTGEELFFDYRY 120
SET_SUV39H_DIM5-like cd19473
SET domain (including pre-SET domain) found in Neurospora crassa (DIM-5) and similar proteins; ...
 1345-1511 6.20e-22

SET domain (including pre-SET domain) found in Neurospora crassa (DIM-5) and similar proteins; This subfamily contains Neurospora crassa DIM-5 (also termed H3-K9-HMTase dim-5, or HKMT) which functions as histone-lysine N-methyltransferase that specifically trimethylates histone H3 to form H3K9me3.


Pssm-ID: 380996 [Multi-domain]  Cd Length: 274  Bit Score: 98.16  E-value: 6.20e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892  1345 RMVYTECSPSnCPAGEKCRNQKIQRHAVAPgVERFMTAD-KGWGVRTKLPIAKGTYILEYVGEVVTEKEFKQRMAS---- 1419
Cdd:cd19473   78 RLPIYECHEG-CACSDDCPNRVVERGRKVP-LQIFRTSDgRGWGVRSTVDIKRGQFVDCYVGEIITPEEAQRRRDAatia 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892  1420 ----IYL------NDTHHYCLHLDGG-LVIDGQRMGSDCRFVNHSCEPNceMQKWSVNG------LSRMVLFAKRAIEEG 1482
Cdd:cd19473  156 qrkdVYLfaldkfSDPDSLDPRLRGDpYEIDGEFMSGPTRFINHSCDPN--LRIFARVGdhadkhIHDLAFFAIKDIPRG 233

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 1335892  1483 EELTYDY----------NFSLFNPSEGQPCRCNTPQCRG 1511
Cdd:cd19473  234 TELTFDYvdgvtgldddAGDEEKEKEMTKCLCGSPKCRG 272
SET_EHMT1 cd10535
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 1350-1510 1.30e-21

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins; EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, or lysine N-methyltransferase 1D (KMT1D)) acts as a histone-lysine N-methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380933 [Multi-domain]  Cd Length: 231  Bit Score: 95.77  E-value: 1.30e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892  1350 ECSPSnCPAGEKCRNQKIQrHAVAPGVERFMTADKGWGVRTKLPIAKGTYILEYVGEVVTEKEFKQRMASIYLNDTHH-- 1427
Cdd:cd10535   69 ECNHA-CSCWRNCRNRVVQ-NGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDNkd 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892  1428 ---YClhldgglvIDGQRMGSDCRFVNHSCEPN-----CEMQKWSVNgLSRMVLFAKRAIEEGEELTYDYNFSLFN-PSE 1498
Cdd:cd10535  147 gevYC--------IDARFYGNVSRFINHHCEPNlvpvrVFMAHQDLR-FPRIAFFSTRLIEAGEQLGFDYGERFWDiKGK 217

                        170
                 ....*....|..
gi 1335892  1499 GQPCRCNTPQCR 1510
Cdd:cd10535  218 LFSCRCGSPKCR 229
SET_SUV39H2 cd10532
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 1350-1511 1.44e-21

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 2 (SUV39H2) and similar proteins; SUV39H2 (EC 2.1.1.43; also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B (KMT1B), or Su(var)3-9 homolog 2) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. It mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions.


Pssm-ID: 380930 [Multi-domain]  Cd Length: 243  Bit Score: 96.11  E-value: 1.44e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892  1350 ECSpSNCPAGEKCRNQKIQRhAVAPGVERFMTAD-KGWGVRTKLPIAKGTYILEYVGEVVTEKEfKQRMASIYLNDTHHY 1428
Cdd:cd10532   62 ECN-SRCKCGPDCPNRVVQK-GTQYSLCIFRTSNgRGWGVKTLQKIKKNSFVMEYVGEVITSEE-AERRGQFYDSKGITY 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892  1429 CLHLD---GGLVIDGQRMGSDCRFVNHSCEPNCEMQKWSVNGLS----RMVLFAKRAIEEGEELTYDY----------NF 1491
Cdd:cd10532  139 LFDLDyesDEFTVDAARYGNVSHFVNHSCDPNLQVFNVFIDNLDtrlpRIALFSTRTIKAGEELTFDYqmkgsgdlssDS 218

                        170       180
                 ....*....|....*....|...
gi 1335892  1492 SLFNPSEGQ---PCRCNTPQCRG 1511
Cdd:cd10532  219 IDNSPAKKRvrtVCKCGAVTCRG 241
SET_LegAS4-like cd10522
SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and ...
 1384-1490 4.85e-21

SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and similar proteins; LegAS4 is a type IV secretion system effector of Legionella pneumophila. It contains a SET domain that is involved in the modification of Lys4 of histone H3 (H3K4) in the nucleolus of the host cell, thereby enhancing heterochromatic rDNA transcription. It also contains an ankyrin repeat domain of unknown function at its C-terminal region.


Pssm-ID: 380920 [Multi-domain]  Cd Length: 122  Bit Score: 90.48  E-value: 4.85e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892  1384 KGWGVRTKLPIAKGTYILEYVGEVVTEkeFKQRMASIYLNDTHhYCLHLDGG-LVIDGQRMGSDCRFVNHSCEPNCEMQK 1462
Cdd:cd10522   13 NGLGLFAAETIAKGEFVGEYTGEVLDR--WEEDRDSVYHYDPL-YPFDLNGDiLVIDAGKKGNLTRFINHSDQPNLELIV 89

                         90       100
                 ....*....|....*....|....*...
gi 1335892  1463 WSVNGLSRMVLFAKRAIEEGEELTYDYN 1490
Cdd:cd10522   90 RTLKGEQHIGFVAIRDIKPGEELFISYG 117
SET_EZH1 cd19217
SET domain found in enhancer of zeste homolog 1 (EZH1) and similar proteins; EZH1 (EC 2.1.1.43) ...
 1385-1492 3.75e-20

SET domain found in enhancer of zeste homolog 1 (EZH1) and similar proteins; EZH1 (EC 2.1.1.43), also termed ENX-2, or histone-lysine N-methyltransferase EZH1, is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. It can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively.


Pssm-ID: 380994  Cd Length: 136  Bit Score: 88.59  E-value: 3.75e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892  1385 GWGVRTKLPIAKGTYILEYVGEVVTEKEFKQRmASIYLNDTHHYCLHLDGGLVIDGQRMGSDCRFVNHSCEPNCEMQKWS 1464
Cdd:cd19217   17 GWGTFIKESVQKNEFISEYCGELISQDEADRR-GKVYDKYMSSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVVM 95

                         90       100
                 ....*....|....*....|....*...
gi 1335892  1465 VNGLSRMVLFAKRAIEEGEELTYDYNFS 1492
Cdd:cd19217   96 VNGDHRIGIFAKRAIQQGEELFFDYRYS 123
SET_SETDB cd10541
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1), ...
 1339-1513 1.00e-19

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1), SET domain bifurcated 2 (SETDB2), and similar proteins; SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis.


Pssm-ID: 380939 [Multi-domain]  Cd Length: 236  Bit Score: 90.68  E-value: 1.00e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892  1339 LDNCLNRMVYtECSPSNCPAGEKCRNQKIQrHAVAPGVERFMTADKGWGVRTKLPIAKGTYILEYVGEVVT----EKEFK 1414
Cdd:cd10541   59 LEECLPTGVY-ECNKLCKCDPNMCQNRLVQ-HGLQVRLQLFKTQNKGWGIRCLDDIAKGTFVCIYAGKILTddfaDKEGL 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892  1415 QRMASIYLNDTHHYclhlDGGLVIDGQRMGSDCRFVNHSCEPNCEMQKWSVNGLSR----MVLFAKRAIEEGEELTYDYN 1490
Cdd:cd10541  137 EMGDEYFANLDHIE----ESCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLrfpwVAFFASKRIKAGTELTWDYN 212

                        170       180
                 ....*....|....*....|....*
gi 1335892  1491 FSLfNPSEGQP--CRCNTPQCRGVI 1513
Cdd:cd10541  213 YEV-GSVEGKEllCCCGSNECRGRL 236
SET_KMT2B cd19207
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2B (KMT2B) ...
 1365-1510 1.18e-18

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2B (KMT2B) and similar proteins; KMT2B (EC2.1.1.43; also termed lysine N-methyltransferase 2B, myeloid/lymphoid or mixed-lineage leukemia protein 4 (MLL2/MLL4), trithorax homolog 2 (TRX2), or WW domain-binding protein 7 (WBP-7)), acts as a histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me). It is required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that precedes resumption of meiosis, oocyte survival and normal zygotic genome activation.


Pssm-ID: 380984 [Multi-domain]  Cd Length: 154  Bit Score: 85.08  E-value: 1.18e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892  1365 QKIQRHAVapGVERfmTADKGWGVRTKLPIAKGTYILEYVGEVVTEKEFKQRMASIYLNDTHHYCLHLDGGLVIDGQRMG 1444
Cdd:cd19207    9 KKTSKEAV--GVYR--SAIHGRGLFCKRNIDAGEMVIEYSGIVIRSVLTDKREKFYDSKGIGCYMFRIDDFDVVDATMHG 84

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1335892  1445 SDCRFVNHSCEPNCEMQKWSVNGLSRMVLFAKRAIEEGEELTYDYNFSLFNPSEGQPCRCNTPQCR 1510
Cdd:cd19207   85 NAARFINHSCEPNCYSRVIHVEGQKHIVIFALRKIYRGEELTYDYKFPIEDASNKLPCNCGAKRCR 150
SET_SETD1A cd19204
SET domain (including post-SET domain) found in SET domain-containing protein 1A (SETD1A) and ...
 1386-1513 1.20e-18

SET domain (including post-SET domain) found in SET domain-containing protein 1A (SETD1A) and similar proteins; SETD1A (EC2.1.1.43), also termed lysine N-methyltransferase 2F, or Set1/Ash2 histone methyltransferase complex subunit SET1, is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me), when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. Human SET domain containing protein 1A (hSETD1A) expression occurs at a high rate in hepatocellular carcinoma patients and controls tumor metastasis in breast cancer by activating MMP expression.


Pssm-ID: 380981 [Multi-domain]  Cd Length: 153  Bit Score: 84.69  E-value: 1.20e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892  1386 WGVRTKLPIAKGTYILEYVGEVVT-------EKEFKQR-MASIYLndthhycLHLDGGLVIDGQRMGSDCRFVNHSCEPN 1457
Cdd:cd19204   26 WGLFAMEPIAADEMVIEYVGQNIRqvvadmrEKRYVQEgIGSSYL-------FRVDHDTIIDATKCGNLARFINHCCTPN 98

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 1335892  1458 CEMQKWSVNGLSRMVLFAKRAIEEGEELTYDYNFSLfnPSEGQPCRCNTPQCRGVI 1513
Cdd:cd19204   99 CYAKVITIESQKKIVIYSKQPIGVNEEITYDYKFPI--EDNKIPCLCGTENCRGTL 152
SET_SETD5-like cd10529
SET domain found in SET domain-containing protein 5 (SETD5), inactive histone-lysine ...
 1394-1491 1.94e-18

SET domain found in SET domain-containing protein 5 (SETD5), inactive histone-lysine N-methyltransferase 2E (KMT2E) and similar proteins; SETD5 is a probable transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. KMT2E (also termed inactive lysine N-methyltransferase 2E or myeloid/lymphoid or mixed-lineage leukemia protein 5 (MLL5)) associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription. The family also includes Saccharomyces cerevisiae SET domain-containing proteins, SET3 and SET4, and Schizosaccharomyces pombe SET3. Most of these family members contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380927  Cd Length: 127  Bit Score: 83.48  E-value: 1.94e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892  1394 IAKGTYILEYVGEVVTEKEFK--QRMASIYLNDTHHYCLHLDGGLVIDGQRMGSDCRFVNHSCEPNCEMQKWSV-NGLSR 1470
Cdd:cd10529   25 ISPGEPILEYKGEVSLRSEFKedNGFFKRPSPFVFFYDGFEGLPLCVDARKYGNEARFIRRSCRPNAELRHVVVsNGELR 104

                         90       100
                 ....*....|....*....|...
gi 1335892  1471 MVLFAKRAIEEGEELT--YDYNF 1491
Cdd:cd10529  105 LFIFALKDIRKGTEITipFDYDY 127
SET_EHMT2 cd10533
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 1350-1510 6.78e-18

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 2 (EHMT2) and similar proteins; EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C (KMT1C), or protein G9a) acts as a histone-lysine N-methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380931 [Multi-domain]  Cd Length: 239  Bit Score: 85.45  E-value: 6.78e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892  1350 ECSPSnCPAGEKCRNQKIQRhAVAPGVERFMTADKGWGVRTKLPIAKGTYILEYVGEVVTEKEFKQRMASIYLNDTHH-- 1427
Cdd:cd10533   69 ECNQA-CSCWRNCKNRVVQS-GIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNkd 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892  1428 ---YClhldgglvIDGQRMGSDCRFVNHSCEPN-----CEMQKWSVNgLSRMVLFAKRAIEEGEELTYDYNFSLFN-PSE 1498
Cdd:cd10533  147 gevYC--------IDARYYGNISRFINHLCDPNiipvrVFMLHQDLR-FPRIAFFSSRDIRTGEELGFDYGDRFWDiKSK 217

                        170
                 ....*....|..
gi 1335892  1499 GQPCRCNTPQCR 1510
Cdd:cd10533  218 YFTCQCGSEKCK 229
SET cd08161
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, ...
 1384-1490 1.42e-17

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, Enhancer-of-zeste, Trithorax (SET) domain superfamily corresponds to SET domain-containing lysine methyltransferases, which catalyze site and state-specific methylation of lysine residues in histones that are fundamental in epigenetic regulation of gene activation and silencing in eukaryotic organisms. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains has been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as N-SET and C-SET. C-SET forms an unusual and conserved knot-like structure of probable functional importance. In addition to N-SET and C-SET, an insert region (I-SET) and flanking regions of high structural variability form part of the overall structure. Some family members contain a pre-SET domain, which is found in a number of histone methyltransferases (HMTase), and a post-SET domain, which harbors a zinc-binding site.


Pssm-ID: 380914 [Multi-domain]  Cd Length: 72  Bit Score: 78.83  E-value: 1.42e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892  1384 KGWGVRTKLPIAKGTYILEyvgevvtekefkqrmasiylndthhyclhldgglvidgqrmgsdCRFVNHSCEPNCEMQKW 1463
Cdd:cd08161   10 AGFGLFATRDIPKGEVIGL--------------------------------------------ARFINHSCEPNCEFEEV 45

                         90       100
                 ....*....|....*....|....*..
gi 1335892  1464 SVNGLSRMVLFAKRAIEEGEELTYDYN 1490
Cdd:cd08161   46 YVGGKPRVFIVALRDIKAGEELTVDYG 72
SET_SpSET3-like cd19183
SET domain (including post-SET domain) found in Schizosaccharomyces pombe SET ...
 1387-1496 4.19e-17

SET domain (including post-SET domain) found in Schizosaccharomyces pombe SET domain-containing protein 3 (SETD3) and similar proteins; Schizosaccharomyces pombe SETD3 functions as a transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. It is required for both, gene activation and repression.


Pssm-ID: 380960  Cd Length: 173  Bit Score: 80.91  E-value: 4.19e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892  1387 GVRTKLPIAKGTYILEYVGEVVTEKEFKQRMASIYLNDTH---HYCLHLDGGLVIDGQRMGSDCRFVNHSCEPNCEMQKW 1463
Cdd:cd19183   15 GLFADRPIPAGDPIQELLGEIGLQSEYIADPENQYQILGApkpHVFFHPQSPLYIDTRRSGSVARFIRRSCRPNAELVTV 94

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 1335892  1464 SVNGLSRM--VLFAKRAIEEGEELTYDYNFSLFNP 1496
Cdd:cd19183   95 ASDSGSVLkfVLYASRDISPGEEITIGWDWDNPHP 129
SET_KMT2C cd19208
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C) ...
 1384-1510 4.73e-17

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C) and similar proteins; KMT2C (EC2.1.1.43; also termed lysine N-methyltransferase 2C, homologous to ALR protein (HALR) myeloid/lymphoid, or mixed-lineage leukemia protein 3 (MLL3)), acts as a histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me) and may be involved in leukemogenesis and developmental disorder. KMT2C is a catalytic subunit of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. Overexpression of KMT2C is associated with estrogen receptor-positive breast cancer; KMT2C mediates the estrogen dependence of breast cancer through regulation of estrogen receptor alpha (ERalpha) enhancer function. KMT2C is frequently mutated in certain populations with diffuse-type gastric adenocarcinomas (DGA); its loss promotes epithelial-to-mesenchymal transition (EMT) and is associated with worse overall survival.


Pssm-ID: 380985 [Multi-domain]  Cd Length: 154  Bit Score: 80.44  E-value: 4.73e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892  1384 KGWGVRTKLPIAKGTYILEYVGEVVtEKEFKQRMASIYLNDTHH-YCLHLDGGLVIDGQRMGSDCRFVNHSCEPNCEMQK 1462
Cdd:cd19208   25 QGLGLYAARDIEKHTMVIEYIGTII-RNEVANRKEKLYESQNRGvYMFRIDNDHVIDATLTGGPARYINHSCAPNCVAEV 103

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 1335892  1463 WSVNGLSRMVLFAKRAIEEGEELTYDYNFSLFNPSEGQPCRCNTPQCR 1510
Cdd:cd19208  104 VTFEKGHKIIISSSRRIQKGEELCYDYKFDFEDDQHKIPCHCGAVNCR 151
SET_SETD1B cd19205
SET domain (including post-SET domain) found in SET domain-containing protein 1B (SETD1B) and ...
 1386-1513 6.45e-17

SET domain (including post-SET domain) found in SET domain-containing protein 1B (SETD1B) and similar proteins; SETD1B (EC2.1.1.43), also termed lysine N-methyltransferase 2G, is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me) when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. Loss of SETD1B occurs in up to half the gastric and colorectal cancers, most commonly via SETD1B mutations, while de novo variants in SETD1B are associated with intellectual disability, epilepsy and autism.


Pssm-ID: 380982 [Multi-domain]  Cd Length: 153  Bit Score: 80.10  E-value: 6.45e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892  1386 WGVRTKLPIAKGTYILEYVGEVVteKEFKQRMASIYLNDT---HHYCLHLDGGLVIDGQRMGSDCRFVNHSCEPNCEMQK 1462
Cdd:cd19205   26 WGLFAMEPIAADEMVIEYVGQNI--RQVIADMREKRYEDEgigSSYMFRVDHDTIIDATKCGNFARFINHSCNPNCYAKV 103

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 1335892  1463 WSVNGLSRMVLFAKRAIEEGEELTYDYNFSLfnPSEGQPCRCNTPQCRGVI 1513
Cdd:cd19205  104 ITVESQKKIVIYSKQHINVNEEITYDYKFPI--EDVKIPCLCGSENCRGTL 152
SET_KMT2D cd19209
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) ...
 1384-1510 1.56e-16

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins; KMT2D (EC2.1.1.43; also termed lysine N-methyltransferase 2D, ALL1-related protein (ALR), or myeloid/lymphoid or mixed-lineage leukemia protein 2 (MLL2)), acts as histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me). It is a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription. KMT2D is a subunit of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation.


Pssm-ID: 380986 [Multi-domain]  Cd Length: 155  Bit Score: 78.97  E-value: 1.56e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892  1384 KGWGVRTKLPIAKGTYILEYVGEVVtEKEFKQRMASIYLNDTHH-YCLHLDGGLVIDGQRMGSDCRFVNHSCEPNCEMQK 1462
Cdd:cd19209   26 QGLGLYAAKDLEKHTMVIEYIGTII-RNEVANRREKIYEEQNRGiYMFRINNEHVIDATLTGGPARYINHSCAPNCVAEV 104

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 1335892  1463 WSVNGLSRMVLFAKRAIEEGEELTYDYNFSLFNPSEGQPCRCNTPQCR 1510
Cdd:cd19209  105 VTFDKEDKIIIISSRRIPKGEELTYDYQFDFEDDQHKIPCHCGAWNCR 152
AWS smart00570
associated with SET domains; subdomain of PRESET
 1324-1372 2.63e-16

associated with SET domains; subdomain of PRESET


Pssm-ID: 197795  Cd Length: 50  Bit Score: 74.74  E-value: 2.63e-16
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|.
gi 1335892     1324 DHPTCNCKNQ--GEKSCLDNCLNRMVYTECsPSNCPAGEKCRNQKIQRHAV 1372
Cdd:smart00570    1 DIMTCECKPTddDETACGSDCLNRMLFIEC-SSSCPCGSYCSNQRFQKRQY 50
SET_SETDB2 cd10523
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 2 (SETDB2) ...
 1350-1513 1.07e-15

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 2 (SETDB2) and similar proteins; SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis.


Pssm-ID: 380921 [Multi-domain]  Cd Length: 266  Bit Score: 79.49  E-value: 1.07e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892  1350 ECSPS-NCPAGeKCRNQKIQrHAVAPGVERFMTADKGWGVRTKLPIAKGTYILEYVGEVVtekefkQRMASIYLNDTHHY 1428
Cdd:cd10523   85 ECNVScKCNRM-LCQNRVVQ-HGLQVRLQVFKTEKKGWGVRCLDDIDKGTFVCIYAGRVL------SRARSPTEPLPPKL 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892  1429 CLHLDGG--------------------LVIDGQRMGSDCRFVNHSCEPNCEMQKWSVNGLSR----MVLFAKRAIEEGEE 1484
Cdd:cd10523  157 ELPSENEvevvtswlilskkrklrenvCFLDASKEGNVGRFLNHSCCPNLFVQNVFVDTHDKnfpwVAFFTNRVVKAGTE 236

                        170       180       190
                 ....*....|....*....|....*....|
gi 1335892  1485 LTYDYNFSLFNPSEGQ-PCRCNTPQCRGVI 1513
Cdd:cd10523  237 LTWDYSYDAGTSPEQEiPCLCGVNKCQKKI 266
BAH pfam01426
BAH domain; This domain has been called BAH (Bromo adjacent homology) domain and has also been ...
 1956-2054 8.09e-13

BAH domain; This domain has been called BAH (Bromo adjacent homology) domain and has also been called ELM1 and BAM (Bromo adjacent motif) domain. The function of this domain is unknown but may be involved in protein-protein interaction.


Pssm-ID: 460207  Cd Length: 120  Bit Score: 66.95  E-value: 8.09e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892    1956 CDIFRVEHLWKNELGKRF-IFGQHFLRPHETFHEPSRRFYPNEVVRVSLYEVVPIELVIGPCWLLDRPTFSKGPPMEcND 2034
Cdd:pfam01426   20 YYVARIEELFEDTKNGKKmVRVQWFYRPEETVHRAGKAFNKDELFLSDEEDDVPLSAIIGKCSVLHKSDLESLDPYK-IK 98

                           90       100
                   ....*....|....*....|
gi 1335892    2035 EDHCYICELRVDKTARFFSK 2054
Cdd:pfam01426   99 EPDDFFCELLYDPKTKSFKK 118
PHD_MLL5 cd15550
PHD finger found in mixed lineage leukemia 5 (MLL5); MLL5 is a histone methyltransferase that ...
 1843-1884 1.10e-12

PHD finger found in mixed lineage leukemia 5 (MLL5); MLL5 is a histone methyltransferase that plays a key role in hematopoiesis, spermatogenesis and cell cycle progression. It contains a single plant homeodomain (PHD) finger followed by a catalytic SET domain. MLL5 can be recruited to E2F1-responsive promoters to stimulate H3K4 trimethylation and transcriptional activation by binding to the cell cycle regulator host cell factor (HCF-1), thereby facilitating the cell cycle G1 to S phase transition. It is also involved in mitotic fidelity and genomic integrity by modulating the stability of the chromosomal passenger complex (CPC) via the interaction with Borealin. Moreover, MLL5 is a component of a complex associated with retinoic acid receptor that requires GlcN Acylation of its SET domain in order to activate its histone lysine methyltransferase activity. It also participates in the camptothecin (CPT)-induced p53 activation. Furthermore, MLL5 indirectly regulates H3K4 methylation, represses cyclin A2 (CycA) expression, and promotes myogenic differentiation.


Pssm-ID: 277025 [Multi-domain]  Cd Length: 44  Bit Score: 64.26  E-value: 1.10e-12
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 1335892  1843 RCICGLYKDEGLMIQCSKCMVWQHTECTKADIDA--DNYQCERC 1884
Cdd:cd15550    1 RCICGFEHDDGFMICCDKCSVWQHGDCMGIDRENipDSYLCEQC 44
AWS pfam17907
AWS domain; This entry represents the AWS (associated with SET domain) domain. This is a zinc ...
 1335-1370 4.68e-12

AWS domain; This entry represents the AWS (associated with SET domain) domain. This is a zinc binding domain. The full AWS domain contains 8 cysteines. This entry represents the N-terminal part of the domain, with the C-terminal part interwoven with the SET domain.


Pssm-ID: 465559  Cd Length: 39  Bit Score: 62.06  E-value: 4.68e-12
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1335892    1335 EKSCLDNCLNRMVYTECSPSNCPAGEKCRNQKIQRH 1370
Cdd:pfam17907    4 PCGCGSDCINRMLFVECTPKTCPCGESCQNQRFQRK 39
SET_EZH-like cd19168
SET domain found in enhancer of zeste homolog 1 (EZH1) and zeste homolog 2 (EZH2) of polycomb ...
 1385-1489 9.96e-12

SET domain found in enhancer of zeste homolog 1 (EZH1) and zeste homolog 2 (EZH2) of polycomb repressive complex 2 (PRC2), and similar proteins; The family includes EZH1 and EZH2. EZH1 (EC 2.1.1.43; also termed ENX-2, or histone-lysine N-methyltransferase EZH1) is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. EZH2 (EC 2.1.1.43; also termed lysine N-methyltransferase 6, ENX-1, or histone-lysine N-methyltransferase EZH2) is a catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Both EZH1 and EZH2 can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. PRC2 is involved in several cancers; EZH2 is overexpressed in breast, liver and prostate cancer, while point mutations in EZH2 alter the substrate preference and product specificity of PRC2 in Non-Hodgkin lymphomas (NHLs). Thus, PRC2 is a popular target for cancer therapeutics.


Pssm-ID: 380945  Cd Length: 124  Bit Score: 64.13  E-value: 9.96e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892  1385 GWGVRTKLPIAKGTYILEYVGEVVTEKEfKQRMASIYLNDTHHYCLHLDGGLVIDGQRMGSDCRFVNHSCEP----NCEM 1460
Cdd:cd19168   13 GLGLFAAEDIKEGEFVIEYTGELISHDE-GVRREHRRGDVSYLYLFEEQEGIWVDAAIYGNLSRYINHATDKvktgNCMP 91

                         90       100
                 ....*....|....*....|....*....
gi 1335892  1461 QKWSVNGLSRMVLFAKRAIEEGEELTYDY 1489
Cdd:cd19168   92 KIMYVNHEWRIKFTAIKDIKIGEELFFNY 120
SET_Suv4-20-like cd10524
SET domain (including post-SET domain) found in Drosophila melanogaster suppressor of ...
 1384-1510 1.80e-10

SET domain (including post-SET domain) found in Drosophila melanogaster suppressor of variegation 4-20 (Suv4-20) and similar proteins; Suv4-20 (also termed Su(var)4-20) is a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-20' of histone H4. It acts as a dominant suppressor of position-effect variegation. The family also includes Suv4-20 homologs, lysine N-methyltransferase 5B (KMT5B) and lysine N-methyltransferase 5C (KMT5C). Both KMT5B (also termed lysine-specific methyltransferase 5B, or suppressor of variegation 4-20 homolog 1, or Su(var)4-20 homolog 1, or Suv4-20h1) and KMT5C (also termed lysine-specific methyltransferase 5C, or suppressor of variegation 4-20 homolog 2, or Su(var)4-20 homolog 2, or Suv4-20h2) are histone methyltransferases that specifically trimethylate 'Lys-20' of histone H4 (H4K20me3). They play central roles in the establishment of constitutive heterochromatin in pericentric heterochromatin regions.


Pssm-ID: 380922 [Multi-domain]  Cd Length: 141  Bit Score: 61.14  E-value: 1.80e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892  1384 KGWGVRTKLPIAKGTYILEYVGEVVTEKEFKQRMASIYLNDTHhyclhldgglVIDGQRMGSDC------RFVNHSCEPN 1457
Cdd:cd10524   18 YGAKIIATKPIKKGEKIHELCGCIAELSEEEEALLRPGGNDFS----------VMYSSRKKCSQlwlgpaAFINHDCRPN 87

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 1335892  1458 CemqKWSVNGLSRMVLFAKRAIEEGEELTYDYNFSLFNPSEGQpCRCNTpqCR 1510
Cdd:cd10524   88 C---KFVPTGKSTACVKVLRDIEPGEEITVYYGDNYFGENNEE-CECET--CE 134
SET_SMYD cd20071
SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing ...
 1378-1489 2.11e-10

SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing protein, and similar proteins; The family includes SET and MYND domain-containing proteins, SMYD1-SYMD5. SMYD1 (EC 2.1.1.43; also termed BOP) is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD2 (also termed HSKM-B, or lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. SMYD5 (also termed protein NN8-4AG, or retinoic acid-induced protein 15) functions as histone lysine methyltransferase that mediates H4K20me3 at heterochromatin regions.


Pssm-ID: 380997 [Multi-domain]  Cd Length: 122  Bit Score: 60.08  E-value: 2.11e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892  1378 RFMTADKGWGVRTKLPIAKGTYILeyvgevvTEKEFkqrmASIYLNDTHHYCLHLDGGLVIDgqRMGSdcrFVNHSCEPN 1457
Cdd:cd20071    3 RESEGSKGRGLVATRDIEPGELIL-------VEKPL----VSVPSNSFSLTDGLNEIGVGLF--PLAS---LLNHSCDPN 66

                         90       100       110
                 ....*....|....*....|....*....|..
gi 1335892  1458 CEmqkWSVNGLSRMVLFAKRAIEEGEELTYDY 1489
Cdd:cd20071   67 AV---VVFDGNGTLRVRALRDIKAGEELTISY 95
SET_ATXR5_6-like cd10539
SET domain found in fungal protein lysine methyltransferase SET5 and similar protein; The ...
 1385-1490 3.28e-10

SET domain found in fungal protein lysine methyltransferase SET5 and similar protein; The family includes Arabidopsis thaliana ATXR5 and ATXR6. Both ATXR5 (also termed protein SET DOMAIN GROUP 15, or TRX-related protein 5) and ATXR6 (also termed protein SET DOMAIN GROUP 34, or TRX-related protein 6) function as histone methyltransferase that specifically monomethylates 'Lys-37' of histone H3 (H3K27me1). They are required for chromatin structure and gene silencing.


Pssm-ID: 380937  Cd Length: 138  Bit Score: 60.12  E-value: 3.28e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892  1385 GWGVRTKLPIAKGTYILEYVGEVvteKEFKQRMasIYLNDTHHYCLHL---DGGLVIDGQRMGSDCRFV----NHSCE-- 1455
Cdd:cd10539   15 GFTVEADGFIKDLTIIAEYTGDV---DYIRNRE--FDDNDSIMTLLLAgdpSKSLVICPDKRGNIARFIsginNHTKDgk 89

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 1335892  1456 --PNCEMQKWSVNGLSRMVLFAKRAIEEGEELTYDYN 1490
Cdd:cd10539   90 kkQNCKCVRYSINGEARVLLVATRDIAKGERLYYDYN 126
PHD smart00249
PHD zinc finger; The plant homeodomain (PHD) finger is a C4HC3 zinc-finger-like motif found in ...
 1844-1884 3.63e-08

PHD zinc finger; The plant homeodomain (PHD) finger is a C4HC3 zinc-finger-like motif found in nuclear proteins thought to be involved in epigenetics and chromatin-mediated transcriptional regulation. The PHD finger binds two zinc ions using the so-called 'cross-brace' motif and is thus structurally related to the RING finger and the FYVE finger. It is not yet known if PHD fingers have a common molecular function. Several reports suggest that it can function as a protein-protein interacton domain and it was recently demonstrated that the PHD finger of p300 can cooperate with the adjacent BROMO domain in nucleosome binding in vitro. Other reports suggesting that the PHD finger is a ubiquitin ligase have been refuted as these domains were RING fingers misidentified as PHD fingers.


Pssm-ID: 214584 [Multi-domain]  Cd Length: 47  Bit Score: 51.44  E-value: 3.63e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1335892     1844 CICGLYKDEGLMIQCSKCMVWQHTEC----TKADIDADNYQCERC 1884
Cdd:smart00249    3 SVCGKPDDGGELLQCDGCDRWYHQTClgppLLEEEPDGKWYCPKC 47
PHD pfam00628
PHD-finger; PHD folds into an interleaved type of Zn-finger chelating 2 Zn ions in a similar ...
 1843-1887 5.79e-08

PHD-finger; PHD folds into an interleaved type of Zn-finger chelating 2 Zn ions in a similar manner to that of the RING and FYVE domains. Several PHD fingers have been identified as binding modules of methylated histone H3.


Pssm-ID: 425785 [Multi-domain]  Cd Length: 51  Bit Score: 50.95  E-value: 5.79e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1335892    1843 RC-ICGLYKDEGLMIQCSKCMVWQHTEC-----TKADIDADNYQCERCEPR 1887
Cdd:pfam00628    1 YCaVCGKSDDGGELVQCDGCDDWFHLAClgpplDPAEIPSGEWLCPECKPK 51
PHD_MMD1_like cd15556
PHD finger found in Arabidopsis thaliana PHD finger protein MALE MEIOCYTE DEATH 1 (MMD1), PHD ...
 1844-1884 5.81e-08

PHD finger found in Arabidopsis thaliana PHD finger protein MALE MEIOCYTE DEATH 1 (MMD1), PHD finger protein MALE STERILITY 1 (MS1), and similar proteins; MMD1 is a plant homeodomain (PHD) finger protein expressed in male meiocytes. It is encoded by the gene DUET, which is required for male meiotic chromosome organization and progression. MMD1 has been implicated in the regulation of gene expression during meiosis. The mmd1 mutation triggers cell death in male meiocytes. MS1 is a nuclear transcriptional activator that is important for tapetal development and pollen wall biosynthesis. It contains a Leu zipper-like domain and a PHD finger motif, both of which are essential for its function.


Pssm-ID: 277031 [Multi-domain]  Cd Length: 46  Bit Score: 50.84  E-value: 5.81e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 1335892  1844 CICGLYKDEG-LMIQCSKCMVWQHTEC---TKADIDADNYQCERC 1884
Cdd:cd15556    2 CSCGTRDDDGeRMIACDVCEVWQHTRCvgiADNEEPPDHFLCRRC 46
BAH cd04370
BAH, or Bromo Adjacent Homology domain (also called ELM1 and BAM for Bromo Adjacent Motif). ...
 1958-2054 3.40e-07

BAH, or Bromo Adjacent Homology domain (also called ELM1 and BAM for Bromo Adjacent Motif). BAH domains have first been described as domains found in the polybromo protein and Yeast Rsc1/Rsc2 (Remodeling of the Structure of Chromatin). They also occur in mammalian DNA methyltransferases and the MTA1 subunits of histone deacetylase complexes. A BAH domain is also found in Yeast Sir3p and in the origin receptor complex protein 1 (Orc1p), where it was found to interact with the N-terminal lobe of the silence information regulator 1 protein (Sir1p), confirming the initial hypothesis that BAH plays a role in protein-protein interactions.


Pssm-ID: 239835 [Multi-domain]  Cd Length: 123  Bit Score: 51.24  E-value: 3.40e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892  1958 IFRVEHLWKNELGKRFIFGQHFLRPHETFHEPSRRFYPNEVVRVSLYEVVPIELVIGPCWLLDRPTFSKGPPMECNDEDH 2037
Cdd:cd04370   25 IARIEELWEDTNGSKQVKVRWFYRPEETPKGLSPFALRRELFLSDHLDEIPVESIIGKCKVLFVSEFEGLKQRPNKIDTD 104

                         90
                 ....*....|....*..
gi 1335892  2038 CYICELRVDKTARFFSK 2054
Cdd:cd04370  105 DFFCRLAYDPTTKEFKA 121
SET_SpSet7-like cd10540
SET domain found in Schizossacharomyces pombe Set7 and similar proteins; Schizosaccharomyces ...
 1381-1495 3.77e-07

SET domain found in Schizossacharomyces pombe Set7 and similar proteins; Schizosaccharomyces pombe Set7 is a novel histone-lysine N-methyltransferase. The family also includes a viral histone H3 lysine 27 methyltransferase from Paramecium bursaria Chlorella virus 1 (PBCV-1).


Pssm-ID: 380938  Cd Length: 112  Bit Score: 50.71  E-value: 3.77e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892  1381 TADKGWGVRTKLPIAKGTyILEYVGEVVTEKEFKQRMASIYLNdthHYCL--HLDGGLVIDGqrMGSdcrFVNHSCEPNC 1458
Cdd:cd10540    7 STLKGRGVFATRPIKKGE-VIEEAPVIVLPKEEYQHLCKTVLD---HYVFswGDGCLALALG--YGS---MFNHSYTPNA 77

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 1335892  1459 EmqKWSVNGLSRMVLFAKRAIEEGEELTYDYNFSLFN 1495
Cdd:cd10540   78 E--YEIDFENQTIVFYALRDIEAGEELTINYGDDLWD 112
PHD_Bye1p_SIZ1_like cd15570
PHD domain found in Saccharomyces cerevisiae bypass of ESS1 protein 1 (Bye1p), the E3 Sumo ...
 1843-1884 8.89e-07

PHD domain found in Saccharomyces cerevisiae bypass of ESS1 protein 1 (Bye1p), the E3 Sumo Ligase SIZ1, and similar proteins; Yeast Bye1p is a nuclear transcription factor with a domain resembling the central domain in the transcription elongation factor TFIIS and plays an inhibitory role during transcription elongation. It functions as a multicopy suppressor of Ess1, a peptidyl-prolyl cis-trans isomerase involved in proline isomerization of the C-terminal domain (CTD) of RNA polymerase II (Pol II). Bye1p contains an N-terminal plant homeodomain (PHD) finger, a central Pol II-binding TFIIS-like domain (TLD) domain, and a C-terminal Spen paralogue and orthologue C-terminal (SPOC) domain. The PHD domain binds to a histone H3 tail peptide containing trimethylated lysine 4 (H3K4me3). The TLD domain is responsible for the association with chromatin. Plant SIZ1 protein is a SUMO (small ubiquitin-related modifier) E3 ligase that facilitates conjugation of SUMO to substrate target proteins (sumoylation) and belongs to the protein inhibitor of activated STAT (PIAS) protein family. It negatively regulates abscisic acid (ABA) signaling, which is dependent on the bZIP transcripton factor ABI5. It also modulates plant growth and plays a role in drought stress response likely through the regulation of gene expression. SIZ1 functions as a floral repressor that not only represses the salicylic acid (SA)-dependent pathway, but also promotes FLOWERING LOCUS C (FLC) expression by repressing FLOWERING LOCUS D (FLD) activity through sumoylation. SIZ1 contains a PHD finger, which specifically binds methylated histone H3 at lysine 4 and arginine 2.


Pssm-ID: 277045  Cd Length: 50  Bit Score: 47.45  E-value: 8.89e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 1335892  1843 RCICGLYKDEGLMIQCSKCMVWQHTEC-----TKADIDADN---YQCERC 1884
Cdd:cd15570    1 RCPCGSSMEDGSMIQCEGCKTWQHMDCvlipdKPADGLPELpskFYCELC 50
SET_SETD5 cd19181
SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and ...
 1388-1492 1.04e-06

SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins; SETD5 is a probable transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. SETD5 loss-of-function mutations are a likely cause of a familial syndromic intellectual disability with variable phenotypic expression.


Pssm-ID: 380958  Cd Length: 150  Bit Score: 50.39  E-value: 1.04e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892  1388 VRTKLPIAKGTYILEYVGEVVTEKEFKqrMASIYLNDTHHYCL---HLDG-GLVIDGQRMGSDCRFVNHSCEPNCEMQKW 1463
Cdd:cd19181   21 LRAARDLALDTLIIEYRGKVMLRQQFE--VNGHFFKRPYPFVLfysKFNGvEMCVDARTFGNDARFIRRSCTPNAEVRHM 98

                         90       100       110
                 ....*....|....*....|....*....|.
gi 1335892  1464 SVNGLSRMVLFAKRAIEEGEELT--YDYNFS 1492
Cdd:cd19181   99 IADGMIHLCIYAVAAIAKDAEVTiaFDYEYS 129
PHD_PHF20L1 cd15633
PHD finger found in PHD finger protein 20-like protein 1 (P20L1); P20L1 is an active malignant ...
 1843-1884 1.44e-06

PHD finger found in PHD finger protein 20-like protein 1 (P20L1); P20L1 is an active malignant brain tumor (MBT) domain-containing protein that binds to monomethylated lysine 142 on DNA (Cytosine-5) Methyltransferase 1 (DNMT1) (DNMT1K142me1) and colocalizes at the perinucleolar space in a SET7-dependent manner. Its MBT domain reads and controls enzyme levels of methylated DNMT1 in cells, thus representing a novel antagonist of DNMT1 proteasomal degradation. In addition to the MBT domain, PHF20L1 also contains two Tudor domains, a plant homeodomain (PHD) finger and the putative DNA-binding domains, AT hook and Cys2His2-type zinc finger.


Pssm-ID: 277103  Cd Length: 46  Bit Score: 46.94  E-value: 1.44e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 1335892  1843 RCICGLYKDEGLMIQCSKCMVWQHTECTKADIDA--DNYQCERC 1884
Cdd:cd15633    1 RCICEMDEENGFMIQCEECLCWQHSVCMGLLEESipEQYICYIC 44
PHD_PHF20_like cd15549
PHD finger found in PHD finger protein 20 (PHF20) and PHD finger protein 20-like protein 1 ...
 1843-1884 2.29e-06

PHD finger found in PHD finger protein 20 (PHF20) and PHD finger protein 20-like protein 1 (P20L1); PHF20, also termed Glioma-expressed antigen 2, or hepatocellular carcinoma-associated antigen 58, or novel zinc finger protein, or transcription factor TZP (referring to Tudor and zinc finger domain containing protein), is a regulator of NF-kappaB activation by disrupting recruitment of PP2A to p65. It also functions as a transcription factor that binds Akt and plays a role in Akt cell survival/growth signaling. Moreover, it transcriptionally regulates p53. The phosphorylation of PHF20 on Ser291 mediated by protein kinase B (PKB) is essential in tumorigenesis via the regulation of p53 mediated signaling. P20L1 is an active malignant brain tumor (MBT) domain-containing protein that binds to monomethylated lysine 142 on DNA (Cytosine-5) Methyltransferase 1 (DNMT1) (DNMT1K142me1) and colocalizes at the perinucleolar space in a SET7-dependent manner. Its MBT domain reads and controls enzyme levels of methylated DNMT1 in cells, thus representing a novel antagonist of DNMT1 proteasomal degradation. Both PHF20 and PHF20L1 contain an N-terminal MBT domain, two Tudor domains, a plant homeodomain (PHD) finger and the putative DNA-binding domains, AT hook and Cys2His2-type zinc finger.


Pssm-ID: 277024  Cd Length: 45  Bit Score: 46.31  E-value: 2.29e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 1335892  1843 RCICGLYKDEGLMIQCSKCMVWQHTECTKADID---ADNYQCERC 1884
Cdd:cd15549    1 HCICGVNEENGLMIQCELCLCWQHGVCMGIEEEesvPERYVCYVC 45
PHD_Hop1p_like cd15558
PHD finger found in Schizosaccharomyces pombe meiosis-specific protein hop1 (Hop1p) and ...
 1843-1884 6.23e-06

PHD finger found in Schizosaccharomyces pombe meiosis-specific protein hop1 (Hop1p) and similar proteins; Fission yeast Hop1p, also termed linear element-associated protein hop1, is an S. pombe homolog of the synaptonemal complex (SC)-associated protein Hop1 in Saccharomyces cerevisiae. In contrast to S. cerevisiae, S. pombe forms thin threads, known as linear elements (LinEs), in meiotic nuclei, instead of a canonical synaptonemal complex. LinEs contain Rec10 protein and are evolutionary relics of SC axial elements. Fission yeast Hop1p is a linear element (LinE)-associated protein. It also associates with Rec10, which plays a role in recruiting the recombination machinery to chromatin. Hop1p contains an N-terminal HORMA (for Hop1p, Rev7p, and MAD2) domain and a C-terminal plant homeodomain (PHD) finger.


Pssm-ID: 277033  Cd Length: 47  Bit Score: 45.13  E-value: 6.23e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 1335892  1843 RCICGLYKDEGLMIQCSKCMVWQHTECT--KADIDA---DNYQCERC 1884
Cdd:cd15558    1 RCECGDWGEDGAMIQCAFCDTWQHLLCYgfESAKDPripDIHVCYRC 47
PHD_PHF20 cd15634
PHD finger found in PHD finger protein 20 (PHF20); PHF20, also termed Glioma-expressed antigen ...
 1843-1884 1.54e-05

PHD finger found in PHD finger protein 20 (PHF20); PHF20, also termed Glioma-expressed antigen 2, or hepatocellular carcinoma-associated antigen 58, or novel zinc finger protein, or transcription factor TZP (referring to Tudor and zinc finger domain containing protein), is a regulator of NF-kappaB activation by disrupting recruitment of PP2A to p65. It also functions as a transcription factor that binds Akt and plays a role in Akt cell survival/growth signaling. Moreover, it transcriptionally regulates p53. The phosphorylation of PHF20 on Ser291 mediated by protein kinase B (PKB) is essential in tumorigenesis via the regulation of p53 mediated signaling. PHF20 contains an N-terminal malignant brain tumor (MBT) domain, two Tudor domains, a plant homeodomain (PHD) finger and the putative DNA-binding domains, AT hook and Cys2His2-type zinc finger.


Pssm-ID: 277104  Cd Length: 44  Bit Score: 43.78  E-value: 1.54e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 1335892  1843 RCICGLYKDEGLMIQCSKCMVWQHTECTK--ADIDADNYQCERC 1884
Cdd:cd15634    1 RCICEVQEENDFMIQCEECLCWQHGVCMGllEDNVPEKYTCYIC 44
PHD_SF cd15489
PHD finger superfamily; The PHD finger superfamily includes a canonical plant homeodomain (PHD) ...
 1844-1884 2.76e-05

PHD finger superfamily; The PHD finger superfamily includes a canonical plant homeodomain (PHD) finger typically characterized as Cys4HisCys3, and a non-canonical extended PHD finger, characterized as Cys2HisCys5HisCys2His. Variations include the RAG2 PHD finger characterized by Cys3His2Cys2His and the PHD finger 5 found in nuclear receptor-binding SET domain-containing proteins characterized by Cys4HisCys2His. The PHD finger is also termed LAP (leukemia-associated protein) motif or TTC (trithorax consensus) domain. Single or multiple copies of PHD fingers have been found in a variety of eukaryotic proteins involved in the control of gene transcription and chromatin dynamics. PHD fingers can recognize the unmodified and modified histone H3 tail, and some have been found to interact with non-histone proteins. They also function as epigenome readers controlling gene expression through molecular recruitment of multi-protein complexes of chromatin regulators and transcription factors. The PHD finger domain SF is structurally similar to the RING and FYVE_like superfamilies.


Pssm-ID: 276966 [Multi-domain]  Cd Length: 48  Bit Score: 43.46  E-value: 2.76e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 1335892  1844 CICGL-YKDEGLMIQCSKCMVWQHTECTKADIDADN----YQCERC 1884
Cdd:cd15489    3 IVCGKgGDLGGELLQCDGCGKWFHADCLGPPLSSFVpngkWICPVC 48
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1002-1265 3.34e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.55  E-value: 3.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892   1002 PNPPLDCERVPQAGEARetfvARTNQKAPRLSVVALE-RLQRPQTPAR-GRPRG-RKPKNREQAEAAPQPPPKSEPEIRP 1078
Cdd:PHA03247 2551 PPPPLPPAAPPAAPDRS----VPPPRPAPRPSEPAVTsRARRPDAPPQsARPRApVDDRGDPRGPAPPSPLPPDTHAPDP 2626

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892   1079 AKKRGR-QPKQPVLEEPPPTPPPQQKKNKMEP-NIRLP---DGIDPNTNFSCKIRLKRRKNLEAGTQPKKE--KPVQPVT 1151
Cdd:PHA03247 2627 PPPSPSpAANEPDPHPPPTVPPPERPRDDPAPgRVSRPrraRRLGRAAQASSPPQRPRRRAARPTVGSLTSlaDPPPPPP 2706

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892   1152 VEEIPPEIPVSQEEIDAEAEAKRVDSIPTEHDP----------LPASESHNPGPQDYASCSESSEDKA-STTSLRKLSKV 1220
Cdd:PHA03247 2707 TPEPAPHALVSATPLPPGPAAARQASPALPAAPappavpagpaTPGGPARPARPPTTAGPPAPAPPAApAAGPPRRLTRP 2786

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1335892   1221 KKTYLVAGLLSNHYKQSLMPPPAKVN-KKPGLEEQVGPASLLPPPP 1265
Cdd:PHA03247 2787 AVASLSESRESLPSPWDPADPPAAVLaPAAALPPAASPAGPLPPPT 2832
PHD_PHF2_like cd15554
PHD finger found in PHF2, PHF8 and KDM7; This family includes PHF2, PHF8, KDM7, and similar ...
 1844-1884 1.01e-04

PHD finger found in PHF2, PHF8 and KDM7; This family includes PHF2, PHF8, KDM7, and similar proteins. PHF2, also termed GRC5, or PHD finger protein 2, is a histone lysine demethylase ubiquitously expressed in various tissues. PHF8, also termed PHD finger protein 8, or KDM7B, is a monomethylated histone H4 lysine 20(H4K20me1) demethylase that transcriptionally regulates many cell cycle genes. It also preferentially acts on H3K9me2 and H3K9me1. PHF8 is modulated by CDC20-containing anaphase-promoting complex (APC (cdc20)) and plays an important role in the G2/M transition. It acts as a critical molecular sensor for mediating retinoic acid (RA) treatment response in RAR alpha-fusion-induced leukemia. Moreover, PHF8 is essential for cytoskeleton dynamics and is associated with X-linked mental retardation. KDM7, also termed JmjC domain-containing histone demethylation protein 1D (JHDM1D), or KIAA1718, is a dual histone demethylase that catalyzes demethylation of monomethylated and dimethylated H3K9 (H3K9me2/me1) and H3K27 (H3K27me2/me1), which functions as an eraser of silencing marks on chromatin during brain development. It also plays a tumor-suppressive role by regulating angiogenesis. All family members contain a plant homeodomain (PHD) finger and a JmjC domain.


Pssm-ID: 277029  Cd Length: 47  Bit Score: 41.60  E-value: 1.01e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 1335892  1844 CICGL-YKDEGLMIQCSKCMVWQHTECTKADI----DADNYQCERC 1884
Cdd:cd15554    2 CICRQpYDVTRFMIECDVCKDWFHGSCVGVEEhqanDIERYHCPNC 47
PHD_TCF19_like cd15517
PHD finger found in Transcription factor 19 (TCF-19), Lysine-specific demethylase KDM5A and ...
 1845-1884 1.72e-04

PHD finger found in Transcription factor 19 (TCF-19), Lysine-specific demethylase KDM5A and KDM5B, and other similar proteins; TCF-19 was identified as a putative trans-activating factor with expression beginning at the late G1-S boundary in dividing cells. It functions as a novel islet factor necessary for proliferation and survival in the INS-1 beta cell line. It plays an important role in susceptibility to both Type 1 Diabetes Mellitus (T1DM) and Type 2 Diabetes Mellitus (T2DM); it has been suggested that it may positively impact beta cell mass under conditions of beta cell stress and increased insulin demand. KDM5A was originally identified as a retinoblastoma protein (Rb)-binding partner and its inactivation may be important for Rb to promote differentiation. It is involved in transcription through interaction with TBP, p107, nuclear receptors, Myc, Sin3/HDAC, Mad1, RBP-J, CLOCK, and BMAL1. KDM5B has a restricted expression pattern in the testis, ovary, and transiently in the mammary gland of the pregnant female and has been shown to be upregulated in breast cancer, prostate cancer, and lung cancer, suggesting a potential role in tumorigenesis. Both KDM5A and KDM5B function as trimethylated histone H3 lysine 4 (H3K4me3) demethylases. This family also includes Caenorhabditis elegans Lysine-specific demethylase 7 homolog (ceKDM7A). ceKDM7A (also termed JmjC domain-containing protein 1.2, PHD finger protein 8 homolog, or PHF8 homolog) is a plant homeodomain (PHD)- and JmjC domain-containing protein that functions as a histone demethylase specific for H3K9me2 and H3K27me2. The binding of the PHD finger to H3K4me3 guides H3K9me2- and H3K27me2-specific demethylation by its catalytic JmjC domain in a trans-histone regulation mechanism. In addition, this family includes plant protein OBERON 1 and OBERON 2, Alfin1-like (AL) proteins, histone acetyltransferases (HATs) HAC, and AT-rich interactive domain-containing protein 4 (ARID4).


Pssm-ID: 276992 [Multi-domain]  Cd Length: 49  Bit Score: 40.99  E-value: 1.72e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 1335892  1845 ICGL--YKDEGLMIQCSKCMVWQHTECTKADI----DADNYQCERC 1884
Cdd:cd15517    4 ICNLetAAVDELWVQCDGCDKWFHQFCLGLSNeryaDEDKFKCPNC 49
SET_KMT5C cd19185
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 5C (KMT5C) ...
 1449-1511 6.22e-04

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 5C (KMT5C) and similar proteins; KMT5C (also termed lysine N-methyltransferase 5C, lysine-specific methyltransferase 5C, suppressor of variegation 4-20 homolog 2, Su(var)4-20 homolog 2 or Suv4-20h2) is a histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4 (H4K20me3). It plays a central role in the establishment of constitutive heterochromatin in pericentric heterochromatin regions.


Pssm-ID: 380962  Cd Length: 142  Bit Score: 42.33  E-value: 6.22e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1335892  1449 FVNHSCEPNCEMQKWSVNGLSRMVLfakRAIEEGEELTYDYNFSLFNpSEGQPCRCNTPQCRG 1511
Cdd:cd19185   79 FINHDCKPNCKFVPADGNAACVKVL---RDIEPGDEVTCFYGEGFFG-EKNEHCECHTCERKG 137
PHD6_KMT2C_like cd15514
PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 5 found in ...
 1849-1884 7.15e-04

PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 5 found in KMT2D; KMT2C, also termed myeloid/lymphoid or mixed-lineage leukemia protein 3 (MLL3), or homologous to ALR protein, is a histone H3 lysine 4 (H3K4) lysine methyltransferase that functions as a circadian factor contributing to genome-scale circadian transcription. It is a component of a large complex that acts as a coactivator of multiple transcription factors, including the bile acid (BA)-activated nuclear receptor, farnesoid X receptor (FXR), a critical player in BA homeostasis. The MLL3 complex is essential for p53 transactivation of small heterodimer partner (SHP). KMT2C is also a part of activating signal cointegrator-2 (ASC-2)-containing complex (ASCOM) that contains the transcriptional coactivator nuclear receptor coactivator 6 (NCOA6), KMT2C and its paralog MLL4. The ASCOM complex is critical for nuclear receptor (NR) activation of bile acid transporter genes and is down regulated in cholestasis. KMT2D, also termed ALL1-related protein (ALR), is encoded by the gene that was named MLL4, a fourth human homolog of Drosophila trithorax, located on chromosome 12. It enzymatically generates trimethylated histone H3 Lysine 4 (H3K4me3). It plays an essential role in differentiating the human pluripotent embryonal carcinoma cell line NTERA-2 clone D1 (NT2/D1) stem cells by activating differentiation-specific genes, such as HOXA1-3 and NESTIN. KMT2D is also a part of ASCOM. Both KMT2C and KMT2D contain the catalytic domain SET, several plant homeodomain (PHD) fingers, two extended PHD (ePHD) fingers, Cys2HisCys5HisCys2His, a RING finger, an HMG (high-mobility group)-binding motif, and two FY-rich regions. This model corresponds to the sixth PHD finger of KMT2C and the fifth PHD finger of KMT2D.


Pssm-ID: 276989  Cd Length: 51  Bit Score: 39.19  E-value: 7.15e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 1335892  1849 YKDEGLMIQCSKCMVWQHTEC----TKADID--ADN-YQCERC 1884
Cdd:cd15514    9 YNEGELIIQCSQCERWLHGACdslrTEEEAEraADNgYRCLLC 51
PHD2_3_BPTF cd15560
PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF); ...
 1844-1884 7.47e-04

PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF); BPTF, also termed nucleosome-remodeling factor subunit BPTF, or fetal Alz-50 clone 1 protein (FAC1), or fetal Alzheimer antigen, functions as a transcriptional regulator that exhibits altered expression and subcellular localization during neuronal development and neurodegenerative diseases such as Alzheimer's disease. It interacts with the human orthologue of the Kelch-like Ech-associated protein (Keap1). Its function and subcellular localization can be regulated by Keap1. Moreover, BPTF is a novel DNA-binding protein that recognizes the DNA sequence CACAACAC and represses transcription through this site in a phosphorylation-dependent manner. Furthermore, BPTF interacts with the Myc-associated zinc finger protein (ZF87/MAZ) and alters its transcriptional activity, which has been implicated in gene regulation in neurodegeneration. Some family members contain two or three plant homeodomain (PHD) fingers, which may be involved in complex formation with histone H3 trimethylated at K4 (H3K4me3). This family corresponds to the second and third PHD fingers.


Pssm-ID: 277035  Cd Length: 47  Bit Score: 39.25  E-value: 7.47e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 1335892  1844 CICGL-YKDEGLMIQCSKCMVWQHTEC---TKADID-ADNYQCERC 1884
Cdd:cd15560    2 CICRTpYDESQFYIGCDRCQDWFHGRCvgiLQSEAEkIDEYVCPQC 47
PHD_SHPRH cd15547
PHD finger found in E3 ubiquitin-protein ligase SHPRH; SHPRH, also termed SNF2, histone-linker, ...
 1844-1884 1.06e-03

PHD finger found in E3 ubiquitin-protein ligase SHPRH; SHPRH, also termed SNF2, histone-linker, PHD and RING finger domain-containing helicase, belongs to the SWI2/SNF2 family of ATP-dependent chromatin remodeling enzymes, containing the Cys3HisCys4 RING-finger characteristic of E3 ubiquitin ligases. It plays a key role in the error-free branch of DNA damage tolerance. As functional homologs of Saccharomyces cerevisiae Rad5, SHPRH and its closely-related protein, helicase like transcription factor (HLTF), act as ubiquitin ligases that cooperatively mediate Ubc13-Mms2-dependent polyubiquitination of proliferating cell nuclear antigen (PCNA) and maintain genomic stability. SHPRH contains a SNF2 domain, a H1.5 (linker histone H1 and H5) domain, a plant homeodomain (PHD) finger, a Cys3HisCys4 RING-finger, and a C-terminal helicase domain.


Pssm-ID: 277022 [Multi-domain]  Cd Length: 47  Bit Score: 38.93  E-value: 1.06e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 1335892  1844 CICG-LYKDEG-LMIQCSKCMVWQHTECTKADIDAD---NYQCERC 1884
Cdd:cd15547    2 CICGeLDEIDNkHRVQCLKCGLWQHAECVNYDEESDkrePYLCPHC 47
PHD_SPP1 cd16039
PHD finger found in Set1 complex component SPP1; Set1C component SPP1, also called COMPASS ...
 1844-1884 1.26e-03

PHD finger found in Set1 complex component SPP1; Set1C component SPP1, also called COMPASS component Spp1, or Complex proteins associated with set1 protein Spp1, or Suppressor of PRP protein 1, is a component of the COMPASS complex that links histone methylation to initiation of meiotic recombination. It induces double-strand break (DSB) formation by tethering to recombinationally cold regions. SPP1 interacts with H3K4me3 and Mer2, a protein required for DSB formation, to promote recruitment of potential meiotic DSB sites to the chromosomal axis. SPP1 contains a PHD finger, a zinc binding motif.


Pssm-ID: 277186  Cd Length: 46  Bit Score: 38.61  E-value: 1.26e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 1335892  1844 CICGLYKDEGLMIQCSKCMVWQHTECTK---ADID-ADNYQCERC 1884
Cdd:cd16039    2 CICQKPDDGRWMIACDGCDEWYHFTCVNipeADVElVDSFFCPPC 46
SET_KMT2E cd19182
SET domain found in inactive histone-lysine N-methyltransferase 2E (KMT2E) and similar ...
 1398-1491 1.43e-03

SET domain found in inactive histone-lysine N-methyltransferase 2E (KMT2E) and similar proteins; KMT2E (also termed inactive lysine N-methyltransferase 2E, myeloid/lymphoid or mixed-lineage leukemia protein 5 (MLL5)) plays a key role in hematopoiesis, spermatogenesis and cell cycle progression. It associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription. Lack of key residues in the SET domain as well as the presence of an unusually large loop in the SET-I subdomain preclude the interaction of MLL5 SET with its cofactor and substrate thus making MLL5 devoid of any in vitro methyltransferase activity on full-length histones and histone H3 peptide.


Pssm-ID: 380959  Cd Length: 129  Bit Score: 40.65  E-value: 1.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892  1398 TYILEYVGEVVTEKEFKQRmaSIYLNDTHHYCL---HLDG-GLVIDGQRMGSDCRFVNHSCEPNCEMQKWSVNGLSRMVL 1473
Cdd:cd19182   31 TLIIEYRGKFMLREQFEAN--GYFFKRPYPFVLfysKFHGlEMCVDARTFGNEARFIRRSCTPNAEVRHVIEDGTIHLYI 108

                         90
                 ....*....|....*...
gi 1335892  1474 FAKRAIEEGEELTYDYNF 1491
Cdd:cd19182  109 YSIRSIPKGTEITIAFDF 126
PHD_KDM7 cd15640
PHD finger found in lysine-specific demethylase 7 (KDM7); KDM7, also termed JmjC ...
 1844-1886 1.89e-03

PHD finger found in lysine-specific demethylase 7 (KDM7); KDM7, also termed JmjC domain-containing histone demethylation protein 1D (JHDM1D), or KIAA1718, is a dual histone demethylase that catalyzes demethylation of monomethylated and dimethylated H3K9 (H3K9me2/me1) and H3K27 (H3K27me2/me1), which functions as an eraser of silencing marks on chromatin during brain development. It also plays a tumor-suppressive role by regulating angiogenesis. KDM7 contains a plant homeodomain (PHD) that binds Lys4-trimethylated histone 3 (H3K4me3) and a jumonji domain that demethylates either H3K9me2 or H3K27me2.


Pssm-ID: 277110  Cd Length: 50  Bit Score: 38.04  E-value: 1.89e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 1335892  1844 CICGL-YKDEGLMIQCSKCMVWQHTECTKAD----IDADNYQCERCEP 1886
Cdd:cd15640    2 CVCRQpYDVNRFMIECDICKDWFHGSCVQVEehhaADIDLYHCPNCEV 49
PHD_Ecm5p_Lid2p_like cd15518
PHD finger found in Saccharomyces cerevisiae extracellular matrix protein 5 (Ecm5p), ...
 1844-1884 4.14e-03

PHD finger found in Saccharomyces cerevisiae extracellular matrix protein 5 (Ecm5p), Schizosaccharomyces pombe Lid2 complex component Lid2p, and similar proteins; The family includes Saccharomyces cerevisiae Ecm5p, Schizosaccharomyces pombe Lid2 complex component Lid2p, and similar proteins. Ecm5p is a JmjC domain-containing protein that directly removes histone lysine methylation via a hydroxylation reaction. It associates with the yeast Snt2p and Rpd3 deacetylase, which may play a role in regulating transcription in response to oxidative stress. Ecm5p promotes oxidative stress tolerance, while Snt2p ultimately decreases tolerance. Ecm5p contains an N-terminal ARID domain, a JmjC domain, and a C-terminal plant homeodomain (PHD) finger. Lid2p is a trimethyl H3K4 (H3K4me3) demethylase responsible for H3K4 hypomethylation in heterochromatin. It interacts with the histone lysine-9 methyltransferase, Clr4, through the Dos1/Clr8-Rik1 complex, and mediates H3K9 methylation and small RNA production. It also acts cooperatively with the histone modification enzymes Set1 and Lsd1 and plays an essential role in cross-talk between H3K4 and H3K9 methylation in euchromatin. Lid2p contains a JmjC domain, three PHD fingers and a JmjN domain. This model includes the second PHD finger of Lid2p.


Pssm-ID: 276993  Cd Length: 45  Bit Score: 36.94  E-value: 4.14e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 1335892  1844 CICGLYkDEGLMIQCSKCMVWQHTECTKAD----IDADNYQCERC 1884
Cdd:cd15518    2 CFCRQG-EGGTMIECEICKEWYHVKCIKNGrwklDDDDKFVCPIC 45
SET_SMYD3 cd19203
SET domain (including post-SET domain) found in SET and MYND domain-containing protein 3 ...
 1450-1489 7.09e-03

SET domain (including post-SET domain) found in SET and MYND domain-containing protein 3 (SMYD3) and similar proteins; SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. It is overexpressed in colorectal, breast, prostate, and hepatocellular tumors, and has been implicated as an oncogene in human malignancies. Methylation of MEKK2 by SMYD3 is important for regulation of the MEK/ERK pathway, suggesting the possibility of selectively targeting SMYD3 in RAS-driven cancers.


Pssm-ID: 380980 [Multi-domain]  Cd Length: 210  Bit Score: 40.04  E-value: 7.09e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 1335892  1450 VNHSCEPNCEMqkwSVNGLsRMVLFAKRAIEEGEELTYDY 1489
Cdd:cd19203  146 LNHSCDPNCVI---VFNGP-HLLLRAIREIEVGEELTISY 181
PHD_ash2p_like cd15583
PHD finger found in Schizosaccharomyces pombe Set1 complex component ash2 (spAsh2p) and ...
 1844-1884 7.16e-03

PHD finger found in Schizosaccharomyces pombe Set1 complex component ash2 (spAsh2p) and similar proteins; spAsh2p, also termed Set1C component ash2, or COMPASS component ash2, or complex proteins associated with set1 protein ash2, or Lid2 complex component ash2, or Lid2C component ash2, is orthologous to Drosophila melanogaster Ash2 protein. Both spAsh2p and D. melanogaster Ash2 contain a plant homeodomain (PHD) finger and a SPRY domain. In contrast, its counterpart in Saccharomyces cerevisiae, Bre2p, has no PHD finger and is not included in this family. spAsh2p shows histone H3 Lys4 (H3K4) methyltransferase activity through its PHD finger. It also interacts with Lid2p in S. pombe. Human Ash2L contains an atypical PHD finger that lacks part of the Cys4HisCys3 signature characteristic of PHD fingers, it binds to only one zinc ion through the second half of the motif and does not have histone tail binding activity.


Pssm-ID: 277058  Cd Length: 50  Bit Score: 36.56  E-value: 7.16e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 1335892  1844 CICGLYKDEGLM-IQCSKCMVWQHTECTKADIDA-----DNYQ--CERC 1884
Cdd:cd15583    2 CYCGKDRNLGEVeLQCSICLKWFHAKCVSIDNGSclpfmTNYQfvCKRC 50
PHD_TAF3 cd15522
PHD finger found in transcription initiation factor TFIID subunit 3 (TAF3); TAF3 (also termed ...
 1843-1884 8.40e-03

PHD finger found in transcription initiation factor TFIID subunit 3 (TAF3); TAF3 (also termed 140 kDa TATA box-binding protein-associated factor, TBP-associated factor 3, transcription initiation factor TFIID 140 kDa subunit (TAF140), or TAFII-140, is an integral component of TFIID) is a general initiation factor (GTF) that plays a key role in preinitiation complex (PIC) assembly through core promoter recognition. The interaction of H3K4me3 with TAF3 directs global TFIID recruitment to active genes, which regulates gene-selective functions of p53 in response to genotoxic stress. TAF3 is highly enriched in embryonic stem cells and is required for endoderm lineage differentiation and prevents premature specification of neuroectoderm and mesoderm. Moreover, TAF3, along with TRF3, forms a complex that is essential for myogenic differentiation. TAF3 contains a plant homeodomain (PHD) finger. This family also includes Drosophila melanogaster BIP2 (Bric-a-brac interacting protein 2) protein, which functions as an interacting partner of D. melanogaster p53 (Dmp53).


Pssm-ID: 276997 [Multi-domain]  Cd Length: 46  Bit Score: 36.11  E-value: 8.40e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 1335892  1843 RC-ICGLYKDEGLMIQCSKCMVWQHTEC---TKADIDADNYQCERC 1884
Cdd:cd15522    1 ICpICKKPDDGSPMIGCDECDDWYHWECvgiTDEPPEEDDWFCPKC 46
SET_KMT5B cd19184
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 5B (KMT5B) ...
 1449-1518 9.66e-03

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 5B (KMT5B) and similar proteins; KMT5B (also termed lysine N-methyltransferase 5B, lysine-specific methyltransferase 5B, suppressor of variegation 4-20 homolog 1, Su(var)4-20 homolog 1 or Suv4-20h1) is a histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4 (H4K20me3). It plays a central role in the establishment of constitutive heterochromatin in pericentric heterochromatin regions.


Pssm-ID: 380961  Cd Length: 144  Bit Score: 38.86  E-value: 9.66e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335892  1449 FVNHSCEPNCemqKWSVNGLSRMVLFAKRAIEEGEELTYDYNFSLFNPSEgQPCRCNTPQCRGVIGGKSQ 1518
Cdd:cd19184   79 FINHDCRPNC---KFVSTGRDTACVKALRDIEPGEEISCYYGDGFFGENN-EFCECYTCERRGTGAFKSR 144
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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