NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|134031990|ref|NP_056585|]
View 

agouti-signaling protein precursor [Mus musculus]

Protein Classification

Agouti domain-containing protein( domain architecture ID 10655107)

Agouti domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Agouti smart00792
Agouti protein; The agouti protein regulates pigmentation in the mouse hair follicle producing ...
 6-127 4.46e-47

Agouti protein; The agouti protein regulates pigmentation in the mouse hair follicle producing a black hair with a subapical yellow band. A highly homologous protein agouti signal protein (ASIP) is present in humans and is expressed at highest levels in adipose tissue where it may play a role in energy homeostasis and possibly human pigmentation.


:

Pssm-ID: 197876  Cd Length: 124  Bit Score: 148.12  E-value: 4.46e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134031990     6 LLLATLVGFLCFFTVHSHLALEETLGDDRSLRSNSSMNSLDFSSVSIVALNKKSKKISRKEAEKRKRSSKKKASMKKVAR 85
Cdd:smart00792   1 MLLATLLGCLLLLTVHSHLGAEEGLEDARGARSNSSLNQADFPSVSIVGLNKKPKKISAEEAEKKLLQKKEKKALTNVLR 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 134031990    86 PPPPSP--CVATRDSCKPPAPACCDPCASCQCRFFGSACTCRVL 127
Cdd:smart00792  81 PEPRSPrrCVRLRDSCKGPQPPCCDPCATCYCRFFNAFCYCRKL 124
 
Name Accession Description Interval E-value
Agouti smart00792
Agouti protein; The agouti protein regulates pigmentation in the mouse hair follicle producing ...
 6-127 4.46e-47

Agouti protein; The agouti protein regulates pigmentation in the mouse hair follicle producing a black hair with a subapical yellow band. A highly homologous protein agouti signal protein (ASIP) is present in humans and is expressed at highest levels in adipose tissue where it may play a role in energy homeostasis and possibly human pigmentation.


Pssm-ID: 197876  Cd Length: 124  Bit Score: 148.12  E-value: 4.46e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134031990     6 LLLATLVGFLCFFTVHSHLALEETLGDDRSLRSNSSMNSLDFSSVSIVALNKKSKKISRKEAEKRKRSSKKKASMKKVAR 85
Cdd:smart00792   1 MLLATLLGCLLLLTVHSHLGAEEGLEDARGARSNSSLNQADFPSVSIVGLNKKPKKISAEEAEKKLLQKKEKKALTNVLR 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 134031990    86 PPPPSP--CVATRDSCKPPAPACCDPCASCQCRFFGSACTCRVL 127
Cdd:smart00792  81 PEPRSPrrCVRLRDSCKGPQPPCCDPCATCYCRFFNAFCYCRKL 124
Agouti pfam05039
Agouti protein; The agouti protein regulates pigmentation in the mouse hair follicle producing ...
 85-126 9.02e-17

Agouti protein; The agouti protein regulates pigmentation in the mouse hair follicle producing a black hair with a subapical yellow band. A highly homologous protein agouti signal protein (ASIP)is present in humans and is expressed at highest levels in adipose tissue where it may play a role in energy homeostasis and possibly human pigmentation.


Pssm-ID: 428273  Cd Length: 43  Bit Score: 68.61  E-value: 9.02e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 134031990   85 RPPPPSPCVATRDSCKPPAPACCDPCASCQCRFFGSACTCRV 126
Cdd:pfam05039   2 RPPPPRRCVRLRESCKPHQVPCCDPCATCYCRFFRAFCYCRV 43
 
Name Accession Description Interval E-value
Agouti smart00792
Agouti protein; The agouti protein regulates pigmentation in the mouse hair follicle producing ...
 6-127 4.46e-47

Agouti protein; The agouti protein regulates pigmentation in the mouse hair follicle producing a black hair with a subapical yellow band. A highly homologous protein agouti signal protein (ASIP) is present in humans and is expressed at highest levels in adipose tissue where it may play a role in energy homeostasis and possibly human pigmentation.


Pssm-ID: 197876  Cd Length: 124  Bit Score: 148.12  E-value: 4.46e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134031990     6 LLLATLVGFLCFFTVHSHLALEETLGDDRSLRSNSSMNSLDFSSVSIVALNKKSKKISRKEAEKRKRSSKKKASMKKVAR 85
Cdd:smart00792   1 MLLATLLGCLLLLTVHSHLGAEEGLEDARGARSNSSLNQADFPSVSIVGLNKKPKKISAEEAEKKLLQKKEKKALTNVLR 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 134031990    86 PPPPSP--CVATRDSCKPPAPACCDPCASCQCRFFGSACTCRVL 127
Cdd:smart00792  81 PEPRSPrrCVRLRDSCKGPQPPCCDPCATCYCRFFNAFCYCRKL 124
Agouti pfam05039
Agouti protein; The agouti protein regulates pigmentation in the mouse hair follicle producing ...
 85-126 9.02e-17

Agouti protein; The agouti protein regulates pigmentation in the mouse hair follicle producing a black hair with a subapical yellow band. A highly homologous protein agouti signal protein (ASIP)is present in humans and is expressed at highest levels in adipose tissue where it may play a role in energy homeostasis and possibly human pigmentation.


Pssm-ID: 428273  Cd Length: 43  Bit Score: 68.61  E-value: 9.02e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 134031990   85 RPPPPSPCVATRDSCKPPAPACCDPCASCQCRFFGSACTCRV 126
Cdd:pfam05039   2 RPPPPRRCVRLRESCKPHQVPCCDPCATCYCRFFRAFCYCRV 43
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH