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Conserved domains on  [gi|13431781|sp|Q9Z0X1|]
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RecName: Full=Apoptosis-inducing factor 1, mitochondrial; AltName: Full=Programmed cell death protein 8; Flags: Precursor

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AIF_C pfam14721
Apoptosis-inducing factor, mitochondrion-associated, C-term; This C-terminal domain appears to ...
 464-593 4.73e-81

Apoptosis-inducing factor, mitochondrion-associated, C-term; This C-terminal domain appears to be a dimerization domain of the mitochondrial apoptosis-inducing factor 1. protein. The domain also appears at the C-terminus of FAD-dependent pyridine nucleotide-disulfide oxidoreductases. Apoptosis inducing factor (AIF) is a bifunctional mitochondrial flavoprotein critical for energy metabolism and induction of caspase-independent apoptosis. On reduction with NADH, AIF undergoes dimerization and forms tight, long-lived FADH2-NAD charge-transfer complexes proposed to be functionally important.


:

Pssm-ID: 464279  Cd Length: 130  Bit Score: 251.03  E-value: 4.73e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781   464 AGENMTGAAKPYWHQSMFWSDLGPDVGYEAIGLVDSSLPTVGVFAKATAQDNPKSATEQSGTGIRSESETESEASEITIP 543
Cdd:pfam14721   1 AGENMTGAGKPYWHQSMFWSDLGPDVGYEAIGIVDSSLPTVGVFAKATEKDTPKAVVEESGESIRSESEEEATASASAAP 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 13431781   544 PSAPAVPQVPVEGEDYGKGVIFYLRDKVVVGIVLWNVFNRMPIARKIIKD 593
Cdd:pfam14721  81 SSEDVASEDPSPGEDYGKGVIFYLRDDKVVGIVLWNVFNRMPIARKIIKD 130
NirB COG1251
NAD(P)H-nitrite reductase, large subunit [Energy production and conversion];
147-595 2.85e-65

NAD(P)H-nitrite reductase, large subunit [Energy production and conversion];


:

Pssm-ID: 440863 [Multi-domain]  Cd Length: 402  Bit Score: 219.24  E-value: 2.85e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781 147 RSIRARDPGARVLIVSEDPELPYMRPPLSKELwfsddpnvtktlqfrqwNGK--ERSIYFQPPSFYvsaqdlpniENGGV 224
Cdd:COG1251  18 EELRKLDPDGEITVIGAEPHPPYNRPPLSKVL-----------------AGEtdEEDLLLRPADFY---------EENGI 71

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781 225 AVLTGKKVVHLDVRGNMVKLNDGSQITFEKCLIATGGTPRSLSAidrAGAEVKSRTTlFRKIGDFRALEKISREVKSITV 304
Cdd:COG1251  72 DLRLGTRVTAIDRAARTVTLADGETLPYDKLVLATGSRPRVPPI---PGADLPGVFT-LRTLDDADALRAALAPGKRVVV 147

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781 305 IGGGFLGSELACALgrksQASGIEVIQLFPEKGNMGKILPQYLSNWTMEKVKREGVKVMPNAIVQSVGVSGGRLLIKLKD 384
Cdd:COG1251 148 IGGGLIGLEAAAAL----RKRGLEVTVVERAPRLLPRQLDEEAGALLQRLLEALGVEVRLGTGVTEIEGDDRVTGVRLAD 223

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781 385 GRKVETDHIVTAVGLEPNVELAKTGGLEIDsdfGGFRVNAELQA-RSNIWVAGDAACFYDIKLGRRRVEHHDHAVVSGRL 463
Cdd:COG1251 224 GEELPADLVVVAIGVRPNTELARAAGLAVD---RGIVVDDYLRTsDPDIYAAGDCAEHPGPVYGRRVLELVAPAYEQARV 300

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781 464 AGENMTGAAKPYWH-QSMFWSDLgPDVGYEAIGLVDsslptvgvfakataqdnpksATEQSgtgirseseteseaseiti 542
Cdd:COG1251 301 AAANLAGGPAAYEGsVPSTKLKV-FGVDVASAGDAE--------------------GDEEV------------------- 340

                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|...
gi 13431781 543 ppsapavpqVPVEGEDYGKGVIFYLRDKVVVGIVLWNVFNRMPIARKIIKDGE 595
Cdd:COG1251 341 ---------VVRGDPARGVYKKLVLRDGRLVGAVLVGDTSDAGALRQLIKNGR 384
AIF-MLS super family cl25936
Mitochondria localization Sequence; This family contains a protein found in eukaryotes. ...
 51-128 4.12e-05

Mitochondria localization Sequence; This family contains a protein found in eukaryotes. Proteins in this family are typically between 240 and 613 amino acids in length. The family is found in association with pfam07992. This protein family is an N-terminal domain for the mitochondrial localization sequence for an apoptosis-inducing factor. The protein is also known as Corneal endothelium-specific protein 1 or as Ovary-specific acidic protein. It is thought to be important for membrane function and is expressed in the ovary and corneal endothelium.


The actual alignment was detected with superfamily member pfam14962:

Pssm-ID: 464407 [Multi-domain]  Cd Length: 192  Bit Score: 44.82  E-value: 4.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781    51 RQMASS---GSSGGKMdnsVLVLIVGLSTIGAGAYAYKTIKEDQKRYNERVMGLG------LSPEEKQRRAIASATEGGS 121
Cdd:pfam14962  31 RRMSSNkfpGSSGSNM---IYYLVVGVTVSAGGYYTYKTVTSEQAKHTEHVTNLKektkaeLHPLQGEKENVAEAEKASS 107


                  ....*...
gi 13431781   122 -VPQIRAP 128
Cdd:pfam14962 108 eAPEVSVV 115
 
Name Accession Description Interval E-value
AIF_C pfam14721
Apoptosis-inducing factor, mitochondrion-associated, C-term; This C-terminal domain appears to ...
 464-593 4.73e-81

Apoptosis-inducing factor, mitochondrion-associated, C-term; This C-terminal domain appears to be a dimerization domain of the mitochondrial apoptosis-inducing factor 1. protein. The domain also appears at the C-terminus of FAD-dependent pyridine nucleotide-disulfide oxidoreductases. Apoptosis inducing factor (AIF) is a bifunctional mitochondrial flavoprotein critical for energy metabolism and induction of caspase-independent apoptosis. On reduction with NADH, AIF undergoes dimerization and forms tight, long-lived FADH2-NAD charge-transfer complexes proposed to be functionally important.


Pssm-ID: 464279  Cd Length: 130  Bit Score: 251.03  E-value: 4.73e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781   464 AGENMTGAAKPYWHQSMFWSDLGPDVGYEAIGLVDSSLPTVGVFAKATAQDNPKSATEQSGTGIRSESETESEASEITIP 543
Cdd:pfam14721   1 AGENMTGAGKPYWHQSMFWSDLGPDVGYEAIGIVDSSLPTVGVFAKATEKDTPKAVVEESGESIRSESEEEATASASAAP 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 13431781   544 PSAPAVPQVPVEGEDYGKGVIFYLRDKVVVGIVLWNVFNRMPIARKIIKD 593
Cdd:pfam14721  81 SSEDVASEDPSPGEDYGKGVIFYLRDDKVVGIVLWNVFNRMPIARKIIKD 130
NirB COG1251
NAD(P)H-nitrite reductase, large subunit [Energy production and conversion];
147-595 2.85e-65

NAD(P)H-nitrite reductase, large subunit [Energy production and conversion];


Pssm-ID: 440863 [Multi-domain]  Cd Length: 402  Bit Score: 219.24  E-value: 2.85e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781 147 RSIRARDPGARVLIVSEDPELPYMRPPLSKELwfsddpnvtktlqfrqwNGK--ERSIYFQPPSFYvsaqdlpniENGGV 224
Cdd:COG1251  18 EELRKLDPDGEITVIGAEPHPPYNRPPLSKVL-----------------AGEtdEEDLLLRPADFY---------EENGI 71

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781 225 AVLTGKKVVHLDVRGNMVKLNDGSQITFEKCLIATGGTPRSLSAidrAGAEVKSRTTlFRKIGDFRALEKISREVKSITV 304
Cdd:COG1251  72 DLRLGTRVTAIDRAARTVTLADGETLPYDKLVLATGSRPRVPPI---PGADLPGVFT-LRTLDDADALRAALAPGKRVVV 147

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781 305 IGGGFLGSELACALgrksQASGIEVIQLFPEKGNMGKILPQYLSNWTMEKVKREGVKVMPNAIVQSVGVSGGRLLIKLKD 384
Cdd:COG1251 148 IGGGLIGLEAAAAL----RKRGLEVTVVERAPRLLPRQLDEEAGALLQRLLEALGVEVRLGTGVTEIEGDDRVTGVRLAD 223

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781 385 GRKVETDHIVTAVGLEPNVELAKTGGLEIDsdfGGFRVNAELQA-RSNIWVAGDAACFYDIKLGRRRVEHHDHAVVSGRL 463
Cdd:COG1251 224 GEELPADLVVVAIGVRPNTELARAAGLAVD---RGIVVDDYLRTsDPDIYAAGDCAEHPGPVYGRRVLELVAPAYEQARV 300

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781 464 AGENMTGAAKPYWH-QSMFWSDLgPDVGYEAIGLVDsslptvgvfakataqdnpksATEQSgtgirseseteseaseiti 542
Cdd:COG1251 301 AAANLAGGPAAYEGsVPSTKLKV-FGVDVASAGDAE--------------------GDEEV------------------- 340

                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|...
gi 13431781 543 ppsapavpqVPVEGEDYGKGVIFYLRDKVVVGIVLWNVFNRMPIARKIIKDGE 595
Cdd:COG1251 341 ---------VVRGDPARGVYKKLVLRDGRLVGAVLVGDTSDAGALRQLIKNGR 384
Pyr_redox_2 pfam07992
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 149-461 6.05e-39

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 400379 [Multi-domain]  Cd Length: 301  Bit Score: 145.15  E-value: 6.05e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781   149 IRARDPGARVLIVSEDPELPYMRPPLSKELWFSDDPnvtktlqfrqwngkeRSIYFQPPSFYVSAQDLPNIENGGVAVLT 228
Cdd:pfam07992  17 LTLAQLGGKVTLIEDEGTCPYGGCVLSKALLGAAEA---------------PEIASLWADLYKRKEEVVKKLNNGIEVLL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781   229 GKKVVHLD-----VRGNMVKLNDGSQITFEKCLIATGGTPRSLSAidrAGAEvKSRTTLFRKIGDFRALEKISREvKSIT 303
Cdd:pfam07992  82 GTEVVSIDpgakkVVLEELVDGDGETITYDRLVIATGARPRLPPI---PGVE-LNVGFLVRTLDSAEALRLKLLP-KRVV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781   304 VIGGGFLGSELACALgrKSQASGIEVIQLFPEkgnMGKILPQYLSNWTMEKVKREGVKVMPNAIVQSVGVSGGRLLIKLK 383
Cdd:pfam07992 157 VVGGGYIGVELAAAL--AKLGKEVTLIEALDR---LLRAFDEEISAALEKALEKNGVEVRLGTSVKEIIGDGDGVEVILK 231

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 13431781   384 DGRKVETDHIVTAVGLEPNVELAKTGGLEIDSDfGGFRVNAELQ-ARSNIWVAGDAacfydiklGRRRVEHHDHAVVSG 461
Cdd:pfam07992 232 DGTEIDADLVVVAIGRRPNTELLEAAGLELDER-GGIVVDEYLRtSVPGIYAAGDC--------RVGGPELAQNAVAQG 301
PRK09754 PRK09754
phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional
 148-484 6.60e-23

phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional


Pssm-ID: 170080 [Multi-domain]  Cd Length: 396  Bit Score: 101.16  E-value: 6.60e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781  148 SIRARDPGARVLIVSEDPELPYMRPPLSKELWFSDDPNVTktlqfrqwngkersiYFQPPSFYVSAQdlpnienggVAVL 227
Cdd:PRK09754  21 SLRQQGFTGELHLFSDERHLPYERPPLSKSMLLEDSPQLQ---------------QVLPANWWQENN---------VHLH 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781  228 TGKKVVHLDVRGNMVKLNDGSQITFEKCLIATGGTPRSLSAIDRAGAEVKSrttlFRKIGDFRALEKISREVKSITVIGG 307
Cdd:PRK09754  77 SGVTIKTLGRDTRELVLTNGESWHWDQLFIATGAAARPLPLLDALGERCFT----LRHAGDAARLREVLQPERSVVIVGA 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781  308 GFLGSELA---CALGRKsqasgIEVIQLfpEKGNMGKILPQYLSNWTMEKVKREGVKVMPNAIVQSVgVSGGRLLIKLKD 384
Cdd:PRK09754 153 GTIGLELAasaTQRRCK-----VTVIEL--AATVMGRNAPPPVQRYLLQRHQQAGVRILLNNAIEHV-VDGEKVELTLQS 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781  385 GRKVETDHIVTAVGLEPNVELAKTGGLEIDsdfGGFRVNAELQ-ARSNIWVAGDAACFYDIKLGRRRVEHHDHAVVSGRL 463
Cdd:PRK09754 225 GETLQADVVIYGIGISANDQLAREANLDTA---NGIVIDEACRtCDPAIFAGGDVAITRLDNGALHRCESWENANNQAQI 301

                        330       340
                 ....*....|....*....|.
gi 13431781  464 AGENMTGAAKPYWHQSMFWSD 484
Cdd:PRK09754 302 AAAAMLGLPLPLLPPPWFWSD 322
AIF-MLS pfam14962
Mitochondria localization Sequence; This family contains a protein found in eukaryotes. ...
 51-128 4.12e-05

Mitochondria localization Sequence; This family contains a protein found in eukaryotes. Proteins in this family are typically between 240 and 613 amino acids in length. The family is found in association with pfam07992. This protein family is an N-terminal domain for the mitochondrial localization sequence for an apoptosis-inducing factor. The protein is also known as Corneal endothelium-specific protein 1 or as Ovary-specific acidic protein. It is thought to be important for membrane function and is expressed in the ovary and corneal endothelium.


Pssm-ID: 464407 [Multi-domain]  Cd Length: 192  Bit Score: 44.82  E-value: 4.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781    51 RQMASS---GSSGGKMdnsVLVLIVGLSTIGAGAYAYKTIKEDQKRYNERVMGLG------LSPEEKQRRAIASATEGGS 121
Cdd:pfam14962  31 RRMSSNkfpGSSGSNM---IYYLVVGVTVSAGGYYTYKTVTSEQAKHTEHVTNLKektkaeLHPLQGEKENVAEAEKASS 107


                  ....*...
gi 13431781   122 -VPQIRAP 128
Cdd:pfam14962 108 eAPEVSVV 115
vWA_transcription_factor_IIH_type cd01453
Transcription factors IIH type: TFIIH is a multiprotein complex that is one of the five ...
 47-121 9.62e-03

Transcription factors IIH type: TFIIH is a multiprotein complex that is one of the five general transcription factors that binds RNA polymerase II holoenzyme. Orthologues of these genes are found in all completed eukaryotic genomes and all these proteins contain a VWA domain. The p44 subunit of TFIIH functions as a DNA helicase in RNA polymerase II transcription initiation and DNA repair, and its transcriptional activity is dependent on its C-terminal Zn-binding domains. The function of the vWA domain is unclear, but may be involved in complex assembly. The MIDAS motif is not conserved in this sub-group.


Pssm-ID: 238730  Cd Length: 183  Bit Score: 37.70  E-value: 9.62e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 13431781  47 LQMARQ----MASSGSsggkmdNSVLVLIVGLSTIGAGAYaYKTIKEdQKRYNERVMGLGLSPEEKQRRAIASATEGGS 121
Cdd:cd01453  92 LEMALEslkhMPSHGS------REVLIIFSSLSTCDPGNI-YETIDK-LKKENIRVSVIGLSAEMHICKEICKATNGTY 162
 
Name Accession Description Interval E-value
AIF_C pfam14721
Apoptosis-inducing factor, mitochondrion-associated, C-term; This C-terminal domain appears to ...
 464-593 4.73e-81

Apoptosis-inducing factor, mitochondrion-associated, C-term; This C-terminal domain appears to be a dimerization domain of the mitochondrial apoptosis-inducing factor 1. protein. The domain also appears at the C-terminus of FAD-dependent pyridine nucleotide-disulfide oxidoreductases. Apoptosis inducing factor (AIF) is a bifunctional mitochondrial flavoprotein critical for energy metabolism and induction of caspase-independent apoptosis. On reduction with NADH, AIF undergoes dimerization and forms tight, long-lived FADH2-NAD charge-transfer complexes proposed to be functionally important.


Pssm-ID: 464279  Cd Length: 130  Bit Score: 251.03  E-value: 4.73e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781   464 AGENMTGAAKPYWHQSMFWSDLGPDVGYEAIGLVDSSLPTVGVFAKATAQDNPKSATEQSGTGIRSESETESEASEITIP 543
Cdd:pfam14721   1 AGENMTGAGKPYWHQSMFWSDLGPDVGYEAIGIVDSSLPTVGVFAKATEKDTPKAVVEESGESIRSESEEEATASASAAP 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 13431781   544 PSAPAVPQVPVEGEDYGKGVIFYLRDKVVVGIVLWNVFNRMPIARKIIKD 593
Cdd:pfam14721  81 SSEDVASEDPSPGEDYGKGVIFYLRDDKVVGIVLWNVFNRMPIARKIIKD 130
NirB COG1251
NAD(P)H-nitrite reductase, large subunit [Energy production and conversion];
147-595 2.85e-65

NAD(P)H-nitrite reductase, large subunit [Energy production and conversion];


Pssm-ID: 440863 [Multi-domain]  Cd Length: 402  Bit Score: 219.24  E-value: 2.85e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781 147 RSIRARDPGARVLIVSEDPELPYMRPPLSKELwfsddpnvtktlqfrqwNGK--ERSIYFQPPSFYvsaqdlpniENGGV 224
Cdd:COG1251  18 EELRKLDPDGEITVIGAEPHPPYNRPPLSKVL-----------------AGEtdEEDLLLRPADFY---------EENGI 71

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781 225 AVLTGKKVVHLDVRGNMVKLNDGSQITFEKCLIATGGTPRSLSAidrAGAEVKSRTTlFRKIGDFRALEKISREVKSITV 304
Cdd:COG1251  72 DLRLGTRVTAIDRAARTVTLADGETLPYDKLVLATGSRPRVPPI---PGADLPGVFT-LRTLDDADALRAALAPGKRVVV 147

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781 305 IGGGFLGSELACALgrksQASGIEVIQLFPEKGNMGKILPQYLSNWTMEKVKREGVKVMPNAIVQSVGVSGGRLLIKLKD 384
Cdd:COG1251 148 IGGGLIGLEAAAAL----RKRGLEVTVVERAPRLLPRQLDEEAGALLQRLLEALGVEVRLGTGVTEIEGDDRVTGVRLAD 223

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781 385 GRKVETDHIVTAVGLEPNVELAKTGGLEIDsdfGGFRVNAELQA-RSNIWVAGDAACFYDIKLGRRRVEHHDHAVVSGRL 463
Cdd:COG1251 224 GEELPADLVVVAIGVRPNTELARAAGLAVD---RGIVVDDYLRTsDPDIYAAGDCAEHPGPVYGRRVLELVAPAYEQARV 300

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781 464 AGENMTGAAKPYWH-QSMFWSDLgPDVGYEAIGLVDsslptvgvfakataqdnpksATEQSgtgirseseteseaseiti 542
Cdd:COG1251 301 AAANLAGGPAAYEGsVPSTKLKV-FGVDVASAGDAE--------------------GDEEV------------------- 340

                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|...
gi 13431781 543 ppsapavpqVPVEGEDYGKGVIFYLRDKVVVGIVLWNVFNRMPIARKIIKDGE 595
Cdd:COG1251 341 ---------VVRGDPARGVYKKLVLRDGRLVGAVLVGDTSDAGALRQLIKNGR 384
FadH2 COG0446
NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase ...
 151-485 7.05e-48

NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase [Lipid transport and metabolism];


Pssm-ID: 440215 [Multi-domain]  Cd Length: 322  Bit Score: 170.38  E-value: 7.05e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781 151 ARDPGARVLIVSEDPELPYMRPPLSKELWFSDDpnvtktlqfrqwngKERSIYFQPPSFYVSAqdlpniengGVAVLTGK 230
Cdd:COG0446   1 RLGPDAEITVIEKGPHHSYQPCGLPYYVGGGIK--------------DPEDLLVRTPESFERK---------GIDVRTGT 57

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781 231 KVVHLDVRGNMVKLNDGSQITFEKCLIATGGTPRSLsAIDraGAEVKSRTTLfRKIGDFRAL-EKI-SREVKSITVIGGG 308
Cdd:COG0446  58 EVTAIDPEAKTVTLRDGETLSYDKLVLATGARPRPP-PIP--GLDLPGVFTL-RTLDDADALrEALkEFKGKRAVVIGGG 133

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781 309 FLGSELACALGRKsqasGIEVIQLFPEKGNMGKILPQYlSNWTMEKVKREGVKVMPNAIVQSVgVSGGRLLIKLKDGRKV 388
Cdd:COG0446 134 PIGLELAEALRKR----GLKVTLVERAPRLLGVLDPEM-AALLEEELREHGVELRLGETVVAI-DGDDKVAVTLTDGEEI 207

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781 389 ETDHIVTAVGLEPNVELAKTGGLEIDSDfGGFRVNAELQAR-SNIWVAGDAACFYDIKLGRR-RVEHHDHAVVSGRLAGE 466
Cdd:COG0446 208 PADLVVVAPGVRPNTELAKDAGLALGER-GWIKVDETLQTSdPDVYAAGDCAEVPHPVTGKTvYIPLASAANKQGRVAAE 286

                       330
                ....*....|....*....
gi 13431781 467 NMTGAAKPYWHQSMFWSDL 485
Cdd:COG0446 287 NILGGPAPFPGLGTFISKV 305
Pyr_redox_2 pfam07992
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 149-461 6.05e-39

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 400379 [Multi-domain]  Cd Length: 301  Bit Score: 145.15  E-value: 6.05e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781   149 IRARDPGARVLIVSEDPELPYMRPPLSKELWFSDDPnvtktlqfrqwngkeRSIYFQPPSFYVSAQDLPNIENGGVAVLT 228
Cdd:pfam07992  17 LTLAQLGGKVTLIEDEGTCPYGGCVLSKALLGAAEA---------------PEIASLWADLYKRKEEVVKKLNNGIEVLL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781   229 GKKVVHLD-----VRGNMVKLNDGSQITFEKCLIATGGTPRSLSAidrAGAEvKSRTTLFRKIGDFRALEKISREvKSIT 303
Cdd:pfam07992  82 GTEVVSIDpgakkVVLEELVDGDGETITYDRLVIATGARPRLPPI---PGVE-LNVGFLVRTLDSAEALRLKLLP-KRVV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781   304 VIGGGFLGSELACALgrKSQASGIEVIQLFPEkgnMGKILPQYLSNWTMEKVKREGVKVMPNAIVQSVGVSGGRLLIKLK 383
Cdd:pfam07992 157 VVGGGYIGVELAAAL--AKLGKEVTLIEALDR---LLRAFDEEISAALEKALEKNGVEVRLGTSVKEIIGDGDGVEVILK 231

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 13431781   384 DGRKVETDHIVTAVGLEPNVELAKTGGLEIDSDfGGFRVNAELQ-ARSNIWVAGDAacfydiklGRRRVEHHDHAVVSG 461
Cdd:pfam07992 232 DGTEIDADLVVVAIGRRPNTELLEAAGLELDER-GGIVVDEYLRtSVPGIYAAGDC--------RVGGPELAQNAVAQG 301
Lpd COG1249
Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex ...
 219-470 2.12e-23

Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase [Energy production and conversion]; Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase is part of the Pathway/BioSystem: Glycine cleavagePyruvate oxidation


Pssm-ID: 440861 [Multi-domain]  Cd Length: 456  Bit Score: 103.63  E-value: 2.12e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781 219 IENGGVAVLTGKKVVhldVRGNMVKLNDGSQITFEKCLIATGGTPRSLSAIDRAGAEVKSRTTLFrkigdfrALEKIsre 298
Cdd:COG1249 101 LKKNGVDVIRGRARF---VDPHTVEVTGGETLTADHIVIATGSRPRVPPIPGLDEVRVLTSDEAL-------ELEEL--- 167

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781 299 VKSITVIGGGFLGSELACALgrksQASGIEVIQLfpekGNMGKILPQY---LSNWTMEKVKREGVKVMPNAIVQSVGVSG 375
Cdd:COG1249 168 PKSLVVIGGGYIGLEFAQIF----ARLGSEVTLV----ERGDRLLPGEdpeISEALEKALEKEGIDILTGAKVTSVEKTG 239

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781 376 GRLLIKLKDGRKVET---DHIVTAVGLEPNVE---LAKTgGLEIDSDfGGFRVNAELQ-ARSNIWVAGDAAcfydiklGR 448
Cdd:COG1249 240 DGVTVTLEDGGGEEAveaDKVLVATGRRPNTDglgLEAA-GVELDER-GGIKVDEYLRtSVPGIYAIGDVT-------GG 310

                       250       260
                ....*....|....*....|..
gi 13431781 449 RRVEHhdHAVVSGRLAGENMTG 470
Cdd:COG1249 311 PQLAH--VASAEGRVAAENILG 330
PRK09754 PRK09754
phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional
 148-484 6.60e-23

phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional


Pssm-ID: 170080 [Multi-domain]  Cd Length: 396  Bit Score: 101.16  E-value: 6.60e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781  148 SIRARDPGARVLIVSEDPELPYMRPPLSKELWFSDDPNVTktlqfrqwngkersiYFQPPSFYVSAQdlpnienggVAVL 227
Cdd:PRK09754  21 SLRQQGFTGELHLFSDERHLPYERPPLSKSMLLEDSPQLQ---------------QVLPANWWQENN---------VHLH 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781  228 TGKKVVHLDVRGNMVKLNDGSQITFEKCLIATGGTPRSLSAIDRAGAEVKSrttlFRKIGDFRALEKISREVKSITVIGG 307
Cdd:PRK09754  77 SGVTIKTLGRDTRELVLTNGESWHWDQLFIATGAAARPLPLLDALGERCFT----LRHAGDAARLREVLQPERSVVIVGA 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781  308 GFLGSELA---CALGRKsqasgIEVIQLfpEKGNMGKILPQYLSNWTMEKVKREGVKVMPNAIVQSVgVSGGRLLIKLKD 384
Cdd:PRK09754 153 GTIGLELAasaTQRRCK-----VTVIEL--AATVMGRNAPPPVQRYLLQRHQQAGVRILLNNAIEHV-VDGEKVELTLQS 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781  385 GRKVETDHIVTAVGLEPNVELAKTGGLEIDsdfGGFRVNAELQ-ARSNIWVAGDAACFYDIKLGRRRVEHHDHAVVSGRL 463
Cdd:PRK09754 225 GETLQADVVIYGIGISANDQLAREANLDTA---NGIVIDEACRtCDPAIFAGGDVAITRLDNGALHRCESWENANNQAQI 301

                        330       340
                 ....*....|....*....|.
gi 13431781  464 AGENMTGAAKPYWHQSMFWSD 484
Cdd:PRK09754 302 AAAAMLGLPLPLLPPPWFWSD 322
Ndh COG1252
NADH dehydrogenase, FAD-containing subunit [Energy production and conversion];
223-467 3.82e-21

NADH dehydrogenase, FAD-containing subunit [Energy production and conversion];


Pssm-ID: 440864 [Multi-domain]  Cd Length: 386  Bit Score: 95.58  E-value: 3.82e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781 223 GVAVLTGKkVVHLDVRGNMVKLNDGSQITFEKCLIATGGTPRsLSAIDraGAE-----VKSR---TTLFRKIgdFRALEK 294
Cdd:COG1252  70 GVRFIQGE-VTGIDPEARTVTLADGRTLSYDYLVIATGSVTN-FFGIP--GLAehalpLKTLedaLALRERL--LAAFER 143

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781 295 ISREVK-SITVIGGGFLGSELACAL----GRKSQASGIEviqlfPEKGN------MGKILPQY---LSNWTMEKVKREGV 360
Cdd:COG1252 144 AERRRLlTIVVVGGGPTGVELAGELaellRKLLRYPGID-----PDKVRitlveaGPRILPGLgekLSEAAEKELEKRGV 218

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781 361 KVMPNAIVQSVGVSGgrllIKLKDGRKVETDHIVTAVGLEPNvELAKTGGLEIDSDfGGFRVNAELQARS--NIWVAGDA 438
Cdd:COG1252 219 EVHTGTRVTEVDADG----VTLEDGEEIPADTVIWAAGVKAP-PLLADLGLPTDRR-GRVLVDPTLQVPGhpNVFAIGDC 292

                       250       260       270
                ....*....|....*....|....*....|....*
gi 13431781 439 ACFYDI------KLGRrrvehhdHAVVSGRLAGEN 467
Cdd:COG1252 293 AAVPDPdgkpvpKTAQ-------AAVQQAKVLAKN 320
PRK09564 PRK09564
coenzyme A disulfide reductase; Reviewed
 223-475 1.09e-17

coenzyme A disulfide reductase; Reviewed


Pssm-ID: 181958 [Multi-domain]  Cd Length: 444  Bit Score: 85.86  E-value: 1.09e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781  223 GVAVLTGKKVVHLDVRGNMVK---LNDGSQI--TFEKCLIATGGTPrSLSAIDraGAEVKSRTTLfRKIGDFRALEKISR 297
Cdd:PRK09564  70 GIDVKTEHEVVKVDAKNKTITvknLKTGSIFndTYDKLMIATGARP-IIPPIK--NINLENVYTL-KSMEDGLALKELLK 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781  298 --EVKSITVIGGGFLGSELACALgrKSQASGIEVIQLfpEKGNMGKILPQYLSNWTMEKVKREGVKVMPNAIVQSVgVSG 375
Cdd:PRK09564 146 deEIKNIVIIGAGFIGLEAVEAA--KHLGKNVRIIQL--EDRILPDSFDKEITDVMEEELRENGVELHLNEFVKSL-IGE 220

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781  376 GRLLIKLKDGRKVETDHIVTAVGLEPNVELAKTGGLEIDSDfGGFRVNAELQAR-SNIWVAGDAACFYDIKLGRRR-VEH 453
Cdd:PRK09564 221 DKVEGVVTDKGEYEADVVIVATGVKPNTEFLEDTGLKTLKN-GAIIVDEYGETSiENIYAAGDCATIYNIVSNKNVyVPL 299

                        250       260
                 ....*....|....*....|..
gi 13431781  454 HDHAVVSGRLAGENMTGAAKPY 475
Cdd:PRK09564 300 ATTANKLGRMVGENLAGRHVSF 321
PRK04965 PRK04965
NADH:flavorubredoxin reductase NorW;
289-439 5.26e-17

NADH:flavorubredoxin reductase NorW;


Pssm-ID: 179902 [Multi-domain]  Cd Length: 377  Bit Score: 83.04  E-value: 5.26e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781  289 FRALEKISREVKSITVIGGGFLGSELACALGRksqaSGIEVIQLFPEKGNMGKILPQYLSNWTMEKVKREGVKVMPNAIV 368
Cdd:PRK04965 131 YRAAETQLRDAQRVLVVGGGLIGTELAMDLCR----AGKAVTLVDNAASLLASLMPPEVSSRLQHRLTEMGVHLLLKSQL 206

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 13431781  369 QSVGVSGGRLLIKLKDGRKVETDHIVTAVGLEPNVELAKTGGLEIDSdfgGFRVNAELQ-ARSNIWVAGDAA 439
Cdd:PRK04965 207 QGLEKTDSGIRATLDSGRSIEVDAVIAAAGLRPNTALARRAGLAVNR---GIVVDSYLQtSAPDIYALGDCA 275
PRK14989 PRK14989
nitrite reductase subunit NirD; Provisional
 220-439 4.89e-16

nitrite reductase subunit NirD; Provisional


Pssm-ID: 184951 [Multi-domain]  Cd Length: 847  Bit Score: 82.09  E-value: 4.89e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781  220 ENGGVAVLTGKKVVHLDVRGNMVKLNDGSQITFEKCLIATGGTPrSLSAIdrAGAEVKSrTTLFRKIGDFRALEKISREV 299
Cdd:PRK14989  70 EKHGIKVLVGERAITINRQEKVIHSSAGRTVFYDKLIMATGSYP-WIPPI--KGSETQD-CFVYRTIEDLNAIEACARRS 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781  300 KSITVIGGGFLGSELACALgrksQASGIE--VIQLFPEKgnMGKILPQYLSNWTMEKVKREGVKVMPNAIVQSVGVSG-- 375
Cdd:PRK14989 146 KRGAVVGGGLLGLEAAGAL----KNLGVEthVIEFAPML--MAEQLDQMGGEQLRRKIESMGVRVHTSKNTLEIVQEGve 219

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 13431781  376 GRLLIKLKDGRKVETDHIVTAVGLEPNVELAKTGGLEIdSDFGGFRVNAELQ-ARSNIWVAGDAA 439
Cdd:PRK14989 220 ARKTMRFADGSELEVDFIVFSTGIRPQDKLATQCGLAV-APRGGIVINDSCQtSDPDIYAIGECA 283
PRK06116 PRK06116
glutathione reductase; Validated
 220-437 6.19e-15

glutathione reductase; Validated


Pssm-ID: 235701 [Multi-domain]  Cd Length: 450  Bit Score: 77.50  E-value: 6.19e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781  220 ENGGVAVLTGKKVVhldVRGNMVKLNdGSQITFEKCLIATGGTPrslSAIDRAGAE--VKSRttlfrkigDFRALEKISr 297
Cdd:PRK06116 104 ENNGVDLIEGFARF---VDAHTVEVN-GERYTADHILIATGGRP---SIPDIPGAEygITSD--------GFFALEELP- 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781  298 evKSITVIGGGFLGSELACALgrksQASGIEVIQLFpeKGNmgKIL---PQYLSNWTMEKVKREGVKVMPNAIVQSVG-V 373
Cdd:PRK06116 168 --KRVAVVGAGYIAVEFAGVL----NGLGSETHLFV--RGD--APLrgfDPDIRETLVEEMEKKGIRLHTNAVPKAVEkN 237

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 13431781  374 SGGRLLIKLKDGRKVETDHIVTAVGLEPNVE---LAKTgGLEIDsDFGGFRVNAELQ-ARSNIWVAGD 437
Cdd:PRK06116 238 ADGSLTLTLEDGETLTVDCLIWAIGREPNTDglgLENA-GVKLN-EKGYIIVDEYQNtNVPGIYAVGD 303
PRK06292 PRK06292
dihydrolipoamide dehydrogenase; Validated
 246-475 3.97e-12

dihydrolipoamide dehydrogenase; Validated


Pssm-ID: 235774 [Multi-domain]  Cd Length: 460  Bit Score: 68.67  E-value: 3.97e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781  246 DGSQITFEKCLIATGGTPRSLSAIDRA-GAEVKSRTTLFRkigdfraLEKISrevKSITVIGGGFLGSELACALGRksqa 324
Cdd:PRK06292 125 NGERIEAKNIVIATGSRVPPIPGVWLIlGDRLLTSDDAFE-------LDKLP---KSLAVIGGGVIGLELGQALSR---- 190

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781  325 SGIEVIqLFpekGNMGKILPQY---LSNWTMEKVKREgVKVMPNAIVQSVGVSGGRLLIKLKDGRKVET---DHIVTAVG 398
Cdd:PRK06292 191 LGVKVT-VF---ERGDRILPLEdpeVSKQAQKILSKE-FKIKLGAKVTSVEKSGDEKVEELEKGGKTETieaDYVLVATG 265

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781  399 LEPNVE---LAKTgGLEIDSDfgGF-RVNAEL-QARSNIWVAGDAAcfydiklGRRRVEHhdHAVVSGRLAGENMTGAAK 473
Cdd:PRK06292 266 RRPNTDglgLENT-GIELDER--GRpVVDEHTqTSVPGIYAAGDVN-------GKPPLLH--EAADEGRIAAENAAGDVA 333


                 ..
gi 13431781  474 PY 475
Cdd:PRK06292 334 GG 335
PRK06370 PRK06370
FAD-containing oxidoreductase;
246-437 8.17e-12

FAD-containing oxidoreductase;


Pssm-ID: 235787 [Multi-domain]  Cd Length: 463  Bit Score: 67.53  E-value: 8.17e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781  246 DGSQITFEKCLIATGGTPR--SLSAIDRAGAevKSRTTLFrkigdfrALEKISRevkSITVIGGGFLGSELACALGRksq 323
Cdd:PRK06370 128 GGETLRAKRIFINTGARAAipPIPGLDEVGY--LTNETIF-------SLDELPE---HLVIIGGGYIGLEFAQMFRR--- 192

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781  324 aSGIEVIQLfpEKGNmgKILPQY---LSNWTMEKVKREGVKVMPNAIVQSVGVSGGRLLIKLK---DGRKVETDHIVTAV 397
Cdd:PRK06370 193 -FGSEVTVI--ERGP--RLLPREdedVAAAVREILEREGIDVRLNAECIRVERDGDGIAVGLDcngGAPEITGSHILVAV 267

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 13431781  398 GLEPNVE---LAKTgGLEIDSDfGGFRVNAELQAR-SNIWVAGD 437
Cdd:PRK06370 268 GRVPNTDdlgLEAA-GVETDAR-GYIKVDDQLRTTnPGIYAAGD 309
Pyr_redox pfam00070
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 301-385 1.97e-09

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 425450 [Multi-domain]  Cd Length: 80  Bit Score: 54.52  E-value: 1.97e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781   301 SITVIGGGFLGSELACALGRKsqasGIEViQLFPEKGNMGKILPQYLSNWTMEKVKREGVKVMPNAIVQSVGVSGGRLLI 380
Cdd:pfam00070   1 RVVVVGGGYIGLELAGALARL----GSKV-TVVERRDRLLPGFDPEIAKILQEKLEKNGIEFLLNTTVEAIEGNGDGVVV 75


                  ....*
gi 13431781   381 KLKDG 385
Cdd:pfam00070  76 VLTDG 80
PRK05249 PRK05249
Si-specific NAD(P)(+) transhydrogenase;
242-473 9.88e-09

Si-specific NAD(P)(+) transhydrogenase;


Pssm-ID: 235373 [Multi-domain]  Cd Length: 461  Bit Score: 57.86  E-value: 9.88e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781  242 VKLNDGS--QITFEKCLIATGGTPRSLSAIDRAGAEVKSRTTLfrkigdfraLEkISREVKSITVIGGGFLGSELAC--- 316
Cdd:PRK05249 126 VECPDGEveTLTADKIVIATGSRPYRPPDVDFDHPRIYDSDSI---------LS-LDHLPRSLIIYGAGVIGCEYASifa 195

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781  317 ALGRKsqasgIEVIQlfpekgNMGKILPqYLSNWTMEKVK---RE-GVKVMPNAIVQSVGVSGGRLLIKLKDGRKVETDH 392
Cdd:PRK05249 196 ALGVK-----VTLIN------TRDRLLS-FLDDEISDALSyhlRDsGVTIRHNEEVEKVEGGDDGVIVHLKSGKKIKADC 263

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781  393 IVTAVGLEPNVE---LAKTgGLEIDSDfGGFRVNAELQ-ARSNIWVAGD-------AACFYDiklgrrrvehhdhavvSG 461
Cdd:PRK05249 264 LLYANGRTGNTDglnLENA-GLEADSR-GQLKVNENYQtAVPHIYAVGDvigfpslASASMD----------------QG 325

                        250
                 ....*....|..
gi 13431781  462 RLAGENMTGAAK 473
Cdd:PRK05249 326 RIAAQHAVGEAT 337
PRK06416 PRK06416
dihydrolipoamide dehydrogenase; Reviewed
 223-439 1.70e-08

dihydrolipoamide dehydrogenase; Reviewed


Pssm-ID: 235798 [Multi-domain]  Cd Length: 462  Bit Score: 57.08  E-value: 1.70e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781  223 GVAVLTGKKVVhldvrgnMVKLNDGSQ-ITFEKCLIATGGTPRSLSAIDRAGaevksrttlfRKIGD-FRALeKISREVK 300
Cdd:PRK06416 112 GEAKLVDPNTV-------RVMTEDGEQtYTAKNIILATGSRPRELPGIEIDG----------RVIWTsDEAL-NLDEVPK 173

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781  301 SITVIGGGFLGSELACA---LGrkSQASGIEVI-QLFP-EKGNMGKILpqylsnwtmEKV-KREGVKVMPNAIVQSVGVS 374
Cdd:PRK06416 174 SLVVIGGGYIGVEFASAyasLG--AEVTIVEALpRILPgEDKEISKLA---------ERAlKKRGIKIKTGAKAKKVEQT 242

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 13431781  375 GGRLLIKLKDGRKVET---DHIVTAVGLEPNVE---LAKTgGLEIDsdfGGF-RVNAELQAR-SNIWVAGDAA 439
Cdd:PRK06416 243 DDGVTVTLEDGGKEETleaDYVLVAVGRRPNTEnlgLEEL-GVKTD---RGFiEVDEQLRTNvPNIYAIGDIV 311
PTZ00058 PTZ00058
glutathione reductase; Provisional
 244-438 5.04e-08

glutathione reductase; Provisional


Pssm-ID: 185420 [Multi-domain]  Cd Length: 561  Bit Score: 55.78  E-value: 5.04e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781  244 LNDGSQITFEKCLIATGGTPRSlsaIDRAGAEVKSRTTLFRKIgdfralekisREVKSITVIGGGFLGSELACALgrksQ 323
Cdd:PTZ00058 195 LDDGQVIEGKNILIAVGNKPIF---PDVKGKEFTISSDDFFKI----------KEAKRIGIAGSGYIAVELINVV----N 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781  324 ASGIEViQLFPEKGNMGKILPQYLSNWTMEKVKREGVKVMPNAIVQSV-GVSGGRLLIKLKDGRKVET-DHIVTAVGLEP 401
Cdd:PTZ00058 258 RLGAES-YIFARGNRLLRKFDETIINELENDMKKNNINIITHANVEEIeKVKEKNLTIYLSDGRKYEHfDYVIYCVGRSP 336

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 13431781  402 NVELAKTGGLEIDSDFGGFRVNA-ELQARSNIWVAGDA 438
Cdd:PTZ00058 337 NTEDLNLKALNIKTPKGYIKVDDnQRTSVKHIYAVGDC 374
PRK07845 PRK07845
flavoprotein disulfide reductase; Reviewed
 223-437 7.81e-08

flavoprotein disulfide reductase; Reviewed


Pssm-ID: 236112 [Multi-domain]  Cd Length: 466  Bit Score: 55.25  E-value: 7.81e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781  223 GVAVLTGK-KVVHLDVRGNMVK--LNDGSQITFEK--CLIATGGTPRSLsaidrAGAEVKSRTTL-FRKIGDFRAL-EKI 295
Cdd:PRK07845 106 GVRVIAGRgRLIDPGLGPHRVKvtTADGGEETLDAdvVLIATGASPRIL-----PTAEPDGERILtWRQLYDLDELpEHL 180

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781  296 srevksiTVIGGGFLGSELACALgrksQASGIEVI------QLFP-EKGNMGKILpqylsnwtmEKV-KREGVKVMPNAI 367
Cdd:PRK07845 181 -------IVVGSGVTGAEFASAY----TELGVKVTlvssrdRVLPgEDADAAEVL---------EEVfARRGMTVLKRSR 240

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781  368 VQSVGVSGGRLLIKLKDGRKVETDHIVTAVGLEPN----------VELAKTGGLEIDsdfggfRVnaelqARSN---IWV 434
Cdd:PRK07845 241 AESVERTGDGVVVTLTDGRTVEGSHALMAVGSVPNtaglgleeagVELTPSGHITVD------RV-----SRTSvpgIYA 309


                 ...
gi 13431781  435 AGD 437
Cdd:PRK07845 310 AGD 312
TrxB COG0492
Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];
231-439 4.48e-06

Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440258 [Multi-domain]  Cd Length: 305  Bit Score: 48.96  E-value: 4.48e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781 231 KVVHLDVRGN--MVKLNDGSQITFEKCLIATGGTPRSLSAidrAGAE----------VKSRTTLFRKigdfralekisre 298
Cdd:COG0492  78 EVTSVDKDDGpfRVTTDDGTEYEAKAVIIATGAGPRKLGL---PGEEefegrgvsycATCDGFFFRG------------- 141

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781 299 vKSITVIGGGFLGSELACAL------------GRKSQASGIEVIQLFpekgnmgkilpqylsnwtmekvKREGVKVMPNA 366
Cdd:COG0492 142 -KDVVVVGGGDSALEEALYLtkfaskvtlihrRDELRASKILVERLR----------------------ANPKIEVLWNT 198

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781 367 IVQSV----GVSGgrllIKLKDG-----RKVETDHIVTAVGLEPNVELAKTGGLEIDSDfGGFRVNAELQ-ARSNIWVAG 436
Cdd:COG0492 199 EVTEIegdgRVEG----VTLKNVktgeeKELEVDGVFVAIGLKPNTELLKGLGLELDED-GYIVVDEDMEtSVPGVFAAG 273


                ...
gi 13431781 437 DAA 439
Cdd:COG0492 274 DVR 276
AIF-MLS pfam14962
Mitochondria localization Sequence; This family contains a protein found in eukaryotes. ...
 51-128 4.12e-05

Mitochondria localization Sequence; This family contains a protein found in eukaryotes. Proteins in this family are typically between 240 and 613 amino acids in length. The family is found in association with pfam07992. This protein family is an N-terminal domain for the mitochondrial localization sequence for an apoptosis-inducing factor. The protein is also known as Corneal endothelium-specific protein 1 or as Ovary-specific acidic protein. It is thought to be important for membrane function and is expressed in the ovary and corneal endothelium.


Pssm-ID: 464407 [Multi-domain]  Cd Length: 192  Bit Score: 44.82  E-value: 4.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781    51 RQMASS---GSSGGKMdnsVLVLIVGLSTIGAGAYAYKTIKEDQKRYNERVMGLG------LSPEEKQRRAIASATEGGS 121
Cdd:pfam14962  31 RRMSSNkfpGSSGSNM---IYYLVVGVTVSAGGYYTYKTVTSEQAKHTEHVTNLKektkaeLHPLQGEKENVAEAEKASS 107


                  ....*...
gi 13431781   122 -VPQIRAP 128
Cdd:pfam14962 108 eAPEVSVV 115
Pyr_redox_3 pfam13738
Pyridine nucleotide-disulphide oxidoreductase;
302-416 3.20e-04

Pyridine nucleotide-disulphide oxidoreductase;


Pssm-ID: 404603 [Multi-domain]  Cd Length: 296  Bit Score: 42.98  E-value: 3.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781   302 ITVIGGGFLGSELACALGRKsqasGIEVIQLFP--EKGNMGKILPQYLSNWT----MEKVKREGVKVMPNAIVQSVGVSG 375
Cdd:pfam13738 158 VVVIGGYNSAVDAALELVRK----GARVTVLYRgsEWEDRDSDPSYSLSPDTlnrlEELVKNGKIKAHFNAEVKEITEVD 233

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 13431781   376 GRLLIKLKDGRKVETDHI-VTAVGLEPNVELAKTGGLEIDSD 416
Cdd:pfam13738 234 VSYKVHTEDGRKVTSNDDpILATGYHPDLSFLKKGLFELDED 275
PRK13512 PRK13512
coenzyme A disulfide reductase; Provisional
 204-439 1.23e-03

coenzyme A disulfide reductase; Provisional


Pssm-ID: 184103 [Multi-domain]  Cd Length: 438  Bit Score: 41.69  E-value: 1.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781  204 FQPPSFYvsaqdlpniENGGVAVLTGKKVVHLDVRGNMV-----KLNDGSQITFEKCLIATGGTPRSLsaidraGAEVKS 278
Cdd:PRK13512  62 YTPEKFY---------DRKQITVKTYHEVIAINDERQTVtvlnrKTNEQFEESYDKLILSPGASANSL------GFESDI 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781  279 RTTLfRKIGDFRALEK-ISR-EVKSITVIGGGFLGSELACALgrksQASGIEViQLFPEKGNMGKILPQYLSNWTMEKVK 356
Cdd:PRK13512 127 TFTL-RNLEDTDAIDQfIKAnQVDKALVVGAGYISLEVLENL----YERGLHP-TLIHRSDKINKLMDADMNQPILDELD 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781  357 REGVKVMPNAIVQSVGVSggrlLIKLKDGRKVETDHIVTAVGLEPNVELAKTGGLEIDsDFGGFRVNAELQAR-SNIWVA 435
Cdd:PRK13512 201 KREIPYRLNEEIDAINGN----EVTFKSGKVEHYDMIIEGVGTHPNSKFIESSNIKLD-DKGFIPVNDKFETNvPNIYAI 275


                 ....
gi 13431781  436 GDAA 439
Cdd:PRK13512 276 GDII 279
PRK06327 PRK06327
dihydrolipoamide dehydrogenase; Validated
 221-437 3.09e-03

dihydrolipoamide dehydrogenase; Validated


Pssm-ID: 235779 [Multi-domain]  Cd Length: 475  Bit Score: 40.29  E-value: 3.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781  221 NGGVAVLTGK-KVVHLDVRGNMVKLNDGS-----------QITFEKCLIATGGTPRSLSAIDRAGAEVKSRTTlfrkigd 288
Cdd:PRK06327 103 TGGIEGLFKKnKITVLKGRGSFVGKTDAGyeikvtgedetVITAKHVIIATGSEPRHLPGVPFDNKIILDNTG------- 175

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781  289 frALEkISREVKSITVIGGGFLGSELACALGRksqaSGIEVIQLfpekgnmgKILPQYL-------SNWTMEKVKREGVK 361
Cdd:PRK06327 176 --ALN-FTEVPKKLAVIGAGVIGLELGSVWRR----LGAEVTIL--------EALPAFLaaadeqvAKEAAKAFTKQGLD 240

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13431781  362 VMPNAIVQSVGVSGGRLLIKLKDG----RKVETDHIVTAVGLEPNVE--LAKTGGLEIDsDFGGFRVNAELQAR-SNIWV 434
Cdd:PRK06327 241 IHLGVKIGEIKTGGKGVSVAYTDAdgeaQTLEVDKLIVSIGRVPNTDglGLEAVGLKLD-ERGFIPVDDHCRTNvPNVYA 319


                 ...
gi 13431781  435 AGD 437
Cdd:PRK06327 320 IGD 322
vWA_transcription_factor_IIH_type cd01453
Transcription factors IIH type: TFIIH is a multiprotein complex that is one of the five ...
 47-121 9.62e-03

Transcription factors IIH type: TFIIH is a multiprotein complex that is one of the five general transcription factors that binds RNA polymerase II holoenzyme. Orthologues of these genes are found in all completed eukaryotic genomes and all these proteins contain a VWA domain. The p44 subunit of TFIIH functions as a DNA helicase in RNA polymerase II transcription initiation and DNA repair, and its transcriptional activity is dependent on its C-terminal Zn-binding domains. The function of the vWA domain is unclear, but may be involved in complex assembly. The MIDAS motif is not conserved in this sub-group.


Pssm-ID: 238730  Cd Length: 183  Bit Score: 37.70  E-value: 9.62e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 13431781  47 LQMARQ----MASSGSsggkmdNSVLVLIVGLSTIGAGAYaYKTIKEdQKRYNERVMGLGLSPEEKQRRAIASATEGGS 121
Cdd:cd01453  92 LEMALEslkhMPSHGS------REVLIIFSSLSTCDPGNI-YETIDK-LKKENIRVSVIGLSAEMHICKEICKATNGTY 162
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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