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Conserved domains on  [gi|1346678|sp|P48744|]
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RecName: Full=Norrin; AltName: Full=Norrie disease protein homolog; Flags: Precursor

Protein Classification

CT domain-containing protein( domain architecture ID 10637066)

CT domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CT smart00041
C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta ...
 41-127 2.46e-14

C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta (TGFbeta), nerve growth factor (NGF), platelet-derived growth factor (PDGF) and gonadotropin all form 2 highly twisted antiparallel pairs of beta-strands and contain three disulphide bonds. The domain is non-globular and little is conserved among these presumed homologues except for their cysteine residues. CT domains are predicted to form homodimers.


:

Pssm-ID: 214482  Cd Length: 82  Bit Score: 63.19  E-value: 2.46e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1346678      41 HYVDSISHPLYKCSSKMVLLARCEGHCSQASRSEplvsfstvlKQPFRSSCHCCRPQTSKLKALRLRCSGGMRLTATYRY 120
Cdd:smart00041   1 KSPVRQTITYNGCTSVTVKNAFCEGKCGSASSYS---------IQDVQHSCSCCQPHKTKTRQVRLRCPDGSTVKKTVMH 71


                   ....*..
gi 1346678     121 ILSCHCE 127
Cdd:smart00041  72 IEECGCE 78
 
Name Accession Description Interval E-value
CT smart00041
C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta ...
 41-127 2.46e-14

C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta (TGFbeta), nerve growth factor (NGF), platelet-derived growth factor (PDGF) and gonadotropin all form 2 highly twisted antiparallel pairs of beta-strands and contain three disulphide bonds. The domain is non-globular and little is conserved among these presumed homologues except for their cysteine residues. CT domains are predicted to form homodimers.


Pssm-ID: 214482  Cd Length: 82  Bit Score: 63.19  E-value: 2.46e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1346678      41 HYVDSISHPLYKCSSKMVLLARCEGHCSQASRSEplvsfstvlKQPFRSSCHCCRPQTSKLKALRLRCSGGMRLTATYRY 120
Cdd:smart00041   1 KSPVRQTITYNGCTSVTVKNAFCEGKCGSASSYS---------IQDVQHSCSCCQPHKTKTRQVRLRCPDGSTVKKTVMH 71


                   ....*..
gi 1346678     121 ILSCHCE 127
Cdd:smart00041  72 IEECGCE 78
 
Name Accession Description Interval E-value
CT smart00041
C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta ...
 41-127 2.46e-14

C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta (TGFbeta), nerve growth factor (NGF), platelet-derived growth factor (PDGF) and gonadotropin all form 2 highly twisted antiparallel pairs of beta-strands and contain three disulphide bonds. The domain is non-globular and little is conserved among these presumed homologues except for their cysteine residues. CT domains are predicted to form homodimers.


Pssm-ID: 214482  Cd Length: 82  Bit Score: 63.19  E-value: 2.46e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1346678      41 HYVDSISHPLYKCSSKMVLLARCEGHCSQASRSEplvsfstvlKQPFRSSCHCCRPQTSKLKALRLRCSGGMRLTATYRY 120
Cdd:smart00041   1 KSPVRQTITYNGCTSVTVKNAFCEGKCGSASSYS---------IQDVQHSCSCCQPHKTKTRQVRLRCPDGSTVKKTVMH 71


                   ....*..
gi 1346678     121 ILSCHCE 127
Cdd:smart00041  72 IEECGCE 78
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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