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Conserved domains on  [gi|13569940|ref|NP_112228|]
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keratin-associated protein 1-3 [Homo sapiens]

Protein Classification

Keratin_B2 domain-containing protein( domain architecture ID 12021880)

Keratin_B2 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 1-167 5.36e-44

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


:

Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 143.01  E-value: 5.36e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569940     1 MTCCQTSFCGYPSCSTSGTCGSSCCQPSCCETSCCQPSCCQTSFCgfpSFSTSGTCSSSCCQPSCCETSCCQPSCCQTSS 80
Cdd:pfam01500   1 MACCGTSFCGFPTCSTGGTCGSGCCQPCCCQSSCCRPSCCQTSCC---QPTTFQSSCCRPTCQPCCQTSCCQPTCCQTSS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569940    81 CGTGCGIGGGIGYGqegSSGAVSTRIRWCRPDCRVEGTCLPPCCVVSCTPPTCCQLHHAEASCCRPSYCGQSCCRPVCCC 160
Cdd:pfam01500  78 CQTGCGGIGYGQEG---SSGAVSSRTRWCRPDCRVEGTCLPPCCVVSCTPPTCCQLHHAQASCCRPSYCGQSCCRPACCC 154


                  ....*..
gi 13569940   161 YSCEPTC 167
Cdd:pfam01500 155 QCSEPTC 161
 
Name Accession Description Interval E-value
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 1-167 5.36e-44

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 143.01  E-value: 5.36e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569940     1 MTCCQTSFCGYPSCSTSGTCGSSCCQPSCCETSCCQPSCCQTSFCgfpSFSTSGTCSSSCCQPSCCETSCCQPSCCQTSS 80
Cdd:pfam01500   1 MACCGTSFCGFPTCSTGGTCGSGCCQPCCCQSSCCRPSCCQTSCC---QPTTFQSSCCRPTCQPCCQTSCCQPTCCQTSS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569940    81 CGTGCGIGGGIGYGqegSSGAVSTRIRWCRPDCRVEGTCLPPCCVVSCTPPTCCQLHHAEASCCRPSYCGQSCCRPVCCC 160
Cdd:pfam01500  78 CQTGCGGIGYGQEG---SSGAVSSRTRWCRPDCRVEGTCLPPCCVVSCTPPTCCQLHHAQASCCRPSYCGQSCCRPACCC 154


                  ....*..
gi 13569940   161 YSCEPTC 167
Cdd:pfam01500 155 QCSEPTC 161
 
Name Accession Description Interval E-value
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 1-167 5.36e-44

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 143.01  E-value: 5.36e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569940     1 MTCCQTSFCGYPSCSTSGTCGSSCCQPSCCETSCCQPSCCQTSFCgfpSFSTSGTCSSSCCQPSCCETSCCQPSCCQTSS 80
Cdd:pfam01500   1 MACCGTSFCGFPTCSTGGTCGSGCCQPCCCQSSCCRPSCCQTSCC---QPTTFQSSCCRPTCQPCCQTSCCQPTCCQTSS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569940    81 CGTGCGIGGGIGYGqegSSGAVSTRIRWCRPDCRVEGTCLPPCCVVSCTPPTCCQLHHAEASCCRPSYCGQSCCRPVCCC 160
Cdd:pfam01500  78 CQTGCGGIGYGQEG---SSGAVSSRTRWCRPDCRVEGTCLPPCCVVSCTPPTCCQLHHAQASCCRPSYCGQSCCRPACCC 154


                  ....*..
gi 13569940   161 YSCEPTC 167
Cdd:pfam01500 155 QCSEPTC 161
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
3-45 1.04e-05

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 40.83  E-value: 1.04e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 13569940     3 CCQTSfCGYPSCSTSGTCGSSCCQPSCCETSCCQPSCCQTSFC 45
Cdd:pfam13885   1 CCQPS-CCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCC 42
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
2-41 3.06e-05

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 39.67  E-value: 3.06e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 13569940     2 TCCQTSFCGyPSCSTSGTCGSSCCQPSCCETSCCQPSCCQ 41
Cdd:pfam13885   5 SCCQPSCCQ-PSCCQPSCCQPSCCQPSCCRPSCCRSSCCQ 43
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
20-77 1.57e-04

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 37.75  E-value: 1.57e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 13569940    20 CGSSCCQPSCCETSCCQPSCCQTSFCgfpsfstsgtcsssccQPSCCETSCCQPSCCQ 77
Cdd:pfam13885   2 CQPSCCQPSCCQPSCCQPSCCQPSCC----------------QPSCCRPSCCRSSCCQ 43
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
119-159 2.08e-03

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 34.67  E-value: 2.08e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 13569940   119 CLPPCCVVSCTPPTCCQLHHAEASCCRPSYCGQSCCRPVCC 159
Cdd:pfam13885   2 CQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCC 42
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
2-38 3.48e-03

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 33.89  E-value: 3.48e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 13569940     2 TCCQTSFCGyPSCSTSGTCGSSCCQPSCCETSCCQPS 38
Cdd:pfam13885  10 SCCQPSCCQ-PSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
123-163 5.84e-03

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 33.51  E-value: 5.84e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 13569940   123 CCVVSCTPPTCCQLHHAEASCCRPSYCGQSCCRPVCCCYSC 163
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSC 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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