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Conserved domains on  [gi|1358962347|gb|AVM85400|]
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NADH dehydrogenase subunit 4L (mitochondrion) [Anopheles gambiae]

Protein Classification

NADH dehydrogenase subunit 4L( domain architecture ID 10009597)

NADH dehydrogenase subunit 4L is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (complex I) that is believed to belong to the minimal assembly required for catalysis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND4L MTH00162
NADH dehydrogenase subunit 4L; Provisional
 7-95 2.42e-25

NADH dehydrogenase subunit 4L; Provisional


:

Pssm-ID: 177218  Cd Length: 89  Bit Score: 90.21  E-value: 2.42e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1358962347   7 FLMFYLSMIMFLFGCMVFVSNRKHLLSTLLSLEYMVLSLFIFLFFYLNFMNYETYFSMFFLTFCVCEGVLGLSILVSMIR 86
Cdd:MTH00162    1 MMMLLIFLFMFFSGLLVFLSKRKHLLLMLLSLEFMVLSLFFLLFLYLSFFNYELYFLLFFLTFSVCEGALGLSILVSMIR 80


                  ....*....
gi 1358962347  87 THGNDYFQS 95
Cdd:MTH00162   81 SHGNDYFSS 89
 
Name Accession Description Interval E-value
ND4L MTH00162
NADH dehydrogenase subunit 4L; Provisional
 7-95 2.42e-25

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177218  Cd Length: 89  Bit Score: 90.21  E-value: 2.42e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1358962347   7 FLMFYLSMIMFLFGCMVFVSNRKHLLSTLLSLEYMVLSLFIFLFFYLNFMNYETYFSMFFLTFCVCEGVLGLSILVSMIR 86
Cdd:MTH00162    1 MMMLLIFLFMFFSGLLVFLSKRKHLLLMLLSLEFMVLSLFFLLFLYLSFFNYELYFLLFFLTFSVCEGALGLSILVSMIR 80


                  ....*....
gi 1358962347  87 THGNDYFQS 95
Cdd:MTH00162   81 SHGNDYFSS 89
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
8-101 5.46e-13

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 59.11  E-value: 5.46e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1358962347   8 LMFYLSMIMFLFGCMVFVSnRKHLLSTLLSLEYMVLSLFIFLFFYLNFMNY--ETYFSMFFLTFCVCEGVLGLSILVSMI 85
Cdd:pfam00420   1 AYLLLSGLLFLIGLYGLLL-RRNLLRVLLSLELMLNAVNLALVLFGRLTADplPQALILTAIVIAAAEAAVGLALLVRIY 79

                          90
                  ....*....|....*.
gi 1358962347  86 RTHGNDYFQSFSILQC 101
Cdd:pfam00420  80 RTHGTDDVDSLNLLKG 95
 
Name Accession Description Interval E-value
ND4L MTH00162
NADH dehydrogenase subunit 4L; Provisional
 7-95 2.42e-25

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177218  Cd Length: 89  Bit Score: 90.21  E-value: 2.42e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1358962347   7 FLMFYLSMIMFLFGCMVFVSNRKHLLSTLLSLEYMVLSLFIFLFFYLNFMNYETYFSMFFLTFCVCEGVLGLSILVSMIR 86
Cdd:MTH00162    1 MMMLLIFLFMFFSGLLVFLSKRKHLLLMLLSLEFMVLSLFFLLFLYLSFFNYELYFLLFFLTFSVCEGALGLSILVSMIR 80


                  ....*....
gi 1358962347  87 THGNDYFQS 95
Cdd:MTH00162   81 SHGNDYFSS 89
ND4L MTH00149
NADH dehydrogenase subunit 4L; Provisional
 6-101 3.15e-16

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 214434  Cd Length: 97  Bit Score: 67.56  E-value: 3.15e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1358962347   6 MFLMFYLSMIMFLFGCMVFVSNRKHLLSTLLSLEYMVLSLFIFLFFYLNFMNYETYFSMFFLTFCVCEGVLGLSILVSMI 85
Cdd:MTH00149    2 MFMLLLLSLFGFLMGVFALLFQYKHLLSILLSLEALMLSLLVMMFSSSGLISFSSYLFLIILTFGACEASLGLSLLVSLI 81

                          90
                  ....*....|....*.
gi 1358962347  86 RTHGNDYFQSFSILQC 101
Cdd:MTH00149   82 RLHGNDYVSSLSSLKF 97
ND4L MTH00188
NADH dehydrogenase subunit 4L; Provisional
 6-101 2.83e-15

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177237  Cd Length: 97  Bit Score: 65.00  E-value: 2.83e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1358962347   6 MFLMFYLSMIMFLFGCMVFVSNRKHLLSTLLSLEYMVLSLFIFLFFYLNFMNYETYFSMFFLTFCVCEGVLGLSILVSMI 85
Cdd:MTH00188    2 FFSMILVILLFVVLGLFTFLLNRKHLLMLLLSLEAIMLSLFWFLLVGLSYMEKELYLSLVLLTFAACEASVGLALLVSLI 81

                          90
                  ....*....|....*.
gi 1358962347  86 RTHGNDYFQSFSILQC 101
Cdd:MTH00188   82 RSHGSDYVSSLNLIKC 97
ND4L MTH00126
NADH dehydrogenase subunit 4L; Provisional
 17-101 1.24e-14

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177185  Cd Length: 98  Bit Score: 63.45  E-value: 1.24e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1358962347  17 FLFGCMVFVSNRKHLLSTLLSLEYMVLSLFIFLFFY---LNFMNYETYfSMFFLTFCVCEGVLGLSILVSMIRTHGNDYF 93
Cdd:MTH00126   12 FILGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWalqLESTSFSAA-PMLLLAFSACEASAGLALLVATARTHGTDRL 90


                  ....*...
gi 1358962347  94 QSFSILQC 101
Cdd:MTH00126   91 QNLNLLQC 98
ND4L MTH00125
NADH dehydrogenase subunit 4L; Provisional
 6-101 1.43e-13

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177184  Cd Length: 98  Bit Score: 60.63  E-value: 1.43e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1358962347   6 MFLMFYLSMIMFLFGCMVFVSNRKHLLSTLLSLEYMVLSLFIFLFFYLNFMNYETYFSM--FFLTFCVCEGVLGLSILVS 83
Cdd:MTH00125    1 MTPTHFSLYTAFMLSLLGLSFHRTHLMSALLCLESMMLSLFIMLSLWPITTQTPSFTPMpiILLTFSACEAGTGLALLVA 80

                          90
                  ....*....|....*...
gi 1358962347  84 MIRTHGNDYFQSFSILQC 101
Cdd:MTH00125   81 TTRTHGSDHLKNLNLLQC 98
ND4L MTH00067
NADH dehydrogenase subunit 4L; Provisional
 6-101 1.66e-13

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177139  Cd Length: 98  Bit Score: 60.39  E-value: 1.66e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1358962347   6 MFLMFYLSMIMFLFGCMVFVSNRKHLLSTLLSLEYMVLSLFIFLFFYLNFMNYETYFS--MFFLTFCVCEGVLGLSILVS 83
Cdd:MTH00067    1 MSPTYFTFYSAFLLGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWSTQFESLSYFSlpMFMLTFSACEASTGLALMVA 80

                          90
                  ....*....|....*...
gi 1358962347  84 MIRTHGNDYFQSFSILQC 101
Cdd:MTH00067   81 TTRTHGTDHLKNLNLLQC 98
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
8-101 5.46e-13

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 59.11  E-value: 5.46e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1358962347   8 LMFYLSMIMFLFGCMVFVSnRKHLLSTLLSLEYMVLSLFIFLFFYLNFMNY--ETYFSMFFLTFCVCEGVLGLSILVSMI 85
Cdd:pfam00420   1 AYLLLSGLLFLIGLYGLLL-RRNLLRVLLSLELMLNAVNLALVLFGRLTADplPQALILTAIVIAAAEAAVGLALLVRIY 79

                          90
                  ....*....|....*.
gi 1358962347  86 RTHGNDYFQSFSILQC 101
Cdd:pfam00420  80 RTHGTDDVDSLNLLKG 95
ND4L MTH00181
NADH dehydrogenase subunit 4L; Provisional
 9-99 2.23e-09

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 214450  Cd Length: 93  Bit Score: 49.94  E-value: 2.23e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1358962347   9 MFYLSMIMFLFGCMVFVSNRKHLLSTLLSLEYMVLSLFIFL--FFYLNFMNYETYFSMFFLTFCVCEGVLGLSILVSMIR 86
Cdd:MTH00181    1 MMFVFISAFILLLLGLSLYKTHLLSLLLCLEGMMLFLFLLLalFSLLSSSSSMLMFGLILLTFSACEAVLGLSLLVATNR 80

                          90
                  ....*....|...
gi 1358962347  87 THGNDYFQSFSIL 99
Cdd:MTH00181   81 THGSDHLLKFNLL 93
ND4L MTH00043
NADH dehydrogenase subunit 4L; Validated
 6-100 5.32e-09

NADH dehydrogenase subunit 4L; Validated


Pssm-ID: 214410  Cd Length: 98  Bit Score: 49.15  E-value: 5.32e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1358962347   6 MFLMFYLSMIMFLFGCMVFVSNRKHLLSTLLSLEYMVLSLFIFLFFYLNFMNYETY--FSMFFLTFCVCEGVLGLSILVS 83
Cdd:MTH00043    1 MNIILIIILSSFFLGLLGILINRLHLLSILLCLELLLISLFLNISIWSLNYGNFSNlsFSLLLLTLSACEASIGLSLMVL 80

                          90
                  ....*....|....*..
gi 1358962347  84 MIRTHGNDYFQSFSILQ 100
Cdd:MTH00043   81 LSRNHNSDLVASLNLLQ 97
ND4L MTH00013
NADH dehydrogenase subunit 4L; Validated
 15-101 9.92e-09

NADH dehydrogenase subunit 4L; Validated


Pssm-ID: 133655  Cd Length: 97  Bit Score: 48.21  E-value: 9.92e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1358962347  15 IMFLFGCMVFVSNRKHLLSTLLSLEYMVLSLFIFLFFYLNFMN-YETYFSMFFLTFCVCEGVLGLSILVSMIRTHGNDYF 93
Cdd:MTH00013   10 ISPFISMFNLSLQRKHLLMSLLSLEAMILSLALFIPLSLMFANqVNGMLAIVLLTFGACEASLGLSLLVLMTRSYGNDML 89


                  ....*...
gi 1358962347  94 QSFSILQC 101
Cdd:MTH00013   90 KSLTSNKC 97
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 3-101 2.61e-08

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177169  Cd Length: 98  Bit Score: 47.23  E-value: 2.61e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1358962347   3 MANMFLMFYLSMIMFLFGCMVFvsnRKHLLSTLLSLEYMVLSLFIFLFFYLNFMNYETYFSM--FFLTFCVCEGVLGLSI 80
Cdd:MTH00107    1 MSLIYMNIMLAFTISLLGLLMY---RSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMpiILLVFAACEAAVGLAL 77

                          90       100
                  ....*....|....*....|.
gi 1358962347  81 LVSMIRTHGNDYFQSFSILQC 101
Cdd:MTH00107   78 LVMVSNTYGTDYVQNLNLLQC 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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