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Conserved domains on  [gi|14318594|gb|AAH09094|]
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Cd47 protein, partial [Mus musculus]

Protein Classification

Ig and CD47 domain-containing protein( domain architecture ID 10958589)

Ig and CD47 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CD47 pfam04549
CD47 transmembrane region; This family represents the transmembrane region of CD47 leukocyte ...
 62-210 6.24e-52

CD47 transmembrane region; This family represents the transmembrane region of CD47 leukocyte antigen.


:

Pssm-ID: 367985  Cd Length: 147  Bit Score: 164.72  E-value: 6.24e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318594    62 LIVIFPILAILLFWGKFGILTLKYKSshTNKRIILLLVAGLVLTVIVVVGAILLIPGEKPVKNASGLGLIVISTGILILL 141
Cdd:pfam04549   1 LIIILLILAIILFWGQLGIITLKYKS--VLKKKIYLYVAGLWITIIVIVGAYLFIPGGYSFKNVIGLGLIVLPAVILIFL 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 14318594   142 QYNVFMTAFGMTSFTIAILITQVLGYVLALVGLCLCIMACEPVHGPLLISGLGIIALAELLGLVYMKFV 210
Cdd:pfam04549  79 QYYLFKTVFKMTYFVIAILILQVIGYVLAVVGLALCVSACPPVYGSLLISGLGIIALAELLGLVYLKIF 147
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 3-51 1.43e-24

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd16090:

Pssm-ID: 472250  Cd Length: 112  Bit Score: 93.46  E-value: 1.43e-24
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 14318594   3 SAKISVSDLINGIASLKMDKRDAMVGNYTCEVTELSREGKTVIELKNRT 51
Cdd:cd16090  64 SANILSSDLLKGNASLTLSKAEAVLGNYTCEVTELNREGETTVELKYRS 112
 
Name Accession Description Interval E-value
CD47 pfam04549
CD47 transmembrane region; This family represents the transmembrane region of CD47 leukocyte ...
 62-210 6.24e-52

CD47 transmembrane region; This family represents the transmembrane region of CD47 leukocyte antigen.


Pssm-ID: 367985  Cd Length: 147  Bit Score: 164.72  E-value: 6.24e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318594    62 LIVIFPILAILLFWGKFGILTLKYKSshTNKRIILLLVAGLVLTVIVVVGAILLIPGEKPVKNASGLGLIVISTGILILL 141
Cdd:pfam04549   1 LIIILLILAIILFWGQLGIITLKYKS--VLKKKIYLYVAGLWITIIVIVGAYLFIPGGYSFKNVIGLGLIVLPAVILIFL 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 14318594   142 QYNVFMTAFGMTSFTIAILITQVLGYVLALVGLCLCIMACEPVHGPLLISGLGIIALAELLGLVYMKFV 210
Cdd:pfam04549  79 QYYLFKTVFKMTYFVIAILILQVIGYVLAVVGLALCVSACPPVYGSLLISGLGIIALAELLGLVYLKIF 147
IgV_CD47 cd16090
Immunoglobulin variable region (IgV) in Cluster of Differentiation (CD) 47; The members here ...
 3-51 1.43e-24

Immunoglobulin variable region (IgV) in Cluster of Differentiation (CD) 47; The members here are composed of immunoglobulin variable (IgV) region in the Cluster of Differentiation (CD) 47 (also known as integrin associated protein/IAP). CD47 partners with membrane integrins and binds thrombospondin-1 (TSP-1) and signal-regulatory protein alpha (SIRP alpha). It is involved in apoptosis, proliferation, adhesion, migration, and immune and angiogenic responses. Members of the IgV family are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond.


Pssm-ID: 409511  Cd Length: 112  Bit Score: 93.46  E-value: 1.43e-24
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 14318594   3 SAKISVSDLINGIASLKMDKRDAMVGNYTCEVTELSREGKTVIELKNRT 51
Cdd:cd16090  64 SANILSSDLLKGNASLTLSKAEAVLGNYTCEVTELNREGETTVELKYRS 112
V-set_CD47 pfam08204
CD47 immunoglobulin-like domain; This family represents the CD47 leukocyte antigen V-set like ...
 6-54 1.72e-13

CD47 immunoglobulin-like domain; This family represents the CD47 leukocyte antigen V-set like Ig domain.


Pssm-ID: 400488  Cd Length: 93  Bit Score: 64.02  E-value: 1.72e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 14318594     6 ISVSDLINGIASLKMDKRDAMVGNYTCEVTELSREGKTVIELKnRTVSW 54
Cdd:pfam08204  46 IFIFNGTNNISTLKFDFSDALSGNYTCEVTELFNEGKTTIELK-YVVSW 93
PHA03042 PHA03042
CD47-like protein; Provisional
 15-205 3.54e-10

CD47-like protein; Provisional


Pssm-ID: 222964 [Multi-domain]  Cd Length: 286  Bit Score: 58.19  E-value: 3.54e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318594   15 IASLKMDKRDAMVGNYTCEVTELSREGKTVIELKnRTVSWFSPNEKILIVIFPILAILLFWGKFGILTLKYKSshtNKRI 94
Cdd:PHA03042  70 TSSLKFNFSKNLSGNYTCEAINKFNKIKNTIELQ-YVIKWFTSEEINVILSLLSIYIIILWGTIITLTFKINK---LKKI 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318594   95 ILLLVAGLVLTVIVVVGAILL-IPGEKPVKNASGLGLIVISTGILILLQYNVFMTaFGMTSFTIAILITQVLGYVLALVG 173
Cdd:PHA03042 146 IYLYAISIWITLIMLVGQYMIgLNTNYIFVKIQGIILIQVSIFSSIFLQIILYKK-IKNSYLLIIVIILKVISYIISFIV 224

                        170       180       190
                 ....*....|....*....|....*....|...
gi 14318594  174 LCLCIMAC-EPVHGPLLISGLGIIALAELLGLV 205
Cdd:PHA03042 225 IILSFIGCyNSIYGYLFIYKLLFINILELSSLV 257
 
Name Accession Description Interval E-value
CD47 pfam04549
CD47 transmembrane region; This family represents the transmembrane region of CD47 leukocyte ...
 62-210 6.24e-52

CD47 transmembrane region; This family represents the transmembrane region of CD47 leukocyte antigen.


Pssm-ID: 367985  Cd Length: 147  Bit Score: 164.72  E-value: 6.24e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318594    62 LIVIFPILAILLFWGKFGILTLKYKSshTNKRIILLLVAGLVLTVIVVVGAILLIPGEKPVKNASGLGLIVISTGILILL 141
Cdd:pfam04549   1 LIIILLILAIILFWGQLGIITLKYKS--VLKKKIYLYVAGLWITIIVIVGAYLFIPGGYSFKNVIGLGLIVLPAVILIFL 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 14318594   142 QYNVFMTAFGMTSFTIAILITQVLGYVLALVGLCLCIMACEPVHGPLLISGLGIIALAELLGLVYMKFV 210
Cdd:pfam04549  79 QYYLFKTVFKMTYFVIAILILQVIGYVLAVVGLALCVSACPPVYGSLLISGLGIIALAELLGLVYLKIF 147
IgV_CD47 cd16090
Immunoglobulin variable region (IgV) in Cluster of Differentiation (CD) 47; The members here ...
 3-51 1.43e-24

Immunoglobulin variable region (IgV) in Cluster of Differentiation (CD) 47; The members here are composed of immunoglobulin variable (IgV) region in the Cluster of Differentiation (CD) 47 (also known as integrin associated protein/IAP). CD47 partners with membrane integrins and binds thrombospondin-1 (TSP-1) and signal-regulatory protein alpha (SIRP alpha). It is involved in apoptosis, proliferation, adhesion, migration, and immune and angiogenic responses. Members of the IgV family are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond.


Pssm-ID: 409511  Cd Length: 112  Bit Score: 93.46  E-value: 1.43e-24
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 14318594   3 SAKISVSDLINGIASLKMDKRDAMVGNYTCEVTELSREGKTVIELKNRT 51
Cdd:cd16090  64 SANILSSDLLKGNASLTLSKAEAVLGNYTCEVTELNREGETTVELKYRS 112
V-set_CD47 pfam08204
CD47 immunoglobulin-like domain; This family represents the CD47 leukocyte antigen V-set like ...
 6-54 1.72e-13

CD47 immunoglobulin-like domain; This family represents the CD47 leukocyte antigen V-set like Ig domain.


Pssm-ID: 400488  Cd Length: 93  Bit Score: 64.02  E-value: 1.72e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 14318594     6 ISVSDLINGIASLKMDKRDAMVGNYTCEVTELSREGKTVIELKnRTVSW 54
Cdd:pfam08204  46 IFIFNGTNNISTLKFDFSDALSGNYTCEVTELFNEGKTTIELK-YVVSW 93
PHA03042 PHA03042
CD47-like protein; Provisional
 15-205 3.54e-10

CD47-like protein; Provisional


Pssm-ID: 222964 [Multi-domain]  Cd Length: 286  Bit Score: 58.19  E-value: 3.54e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318594   15 IASLKMDKRDAMVGNYTCEVTELSREGKTVIELKnRTVSWFSPNEKILIVIFPILAILLFWGKFGILTLKYKSshtNKRI 94
Cdd:PHA03042  70 TSSLKFNFSKNLSGNYTCEAINKFNKIKNTIELQ-YVIKWFTSEEINVILSLLSIYIIILWGTIITLTFKINK---LKKI 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318594   95 ILLLVAGLVLTVIVVVGAILL-IPGEKPVKNASGLGLIVISTGILILLQYNVFMTaFGMTSFTIAILITQVLGYVLALVG 173
Cdd:PHA03042 146 IYLYAISIWITLIMLVGQYMIgLNTNYIFVKIQGIILIQVSIFSSIFLQIILYKK-IKNSYLLIIVIILKVISYIISFIV 224

                        170       180       190
                 ....*....|....*....|....*....|...
gi 14318594  174 LCLCIMAC-EPVHGPLLISGLGIIALAELLGLV 205
Cdd:PHA03042 225 IILSFIGCyNSIYGYLFIYKLLFINILELSSLV 257
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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