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Conserved domains on  [gi|14589891|ref|NP_001784|]
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cadherin-3 isoform 1 preproprotein [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 219-324 1.39e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.01  E-value: 1.39e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589891 219 TFRGSVLEGVLPGTSVMQVTATDEDDAIytyNGVVAYSIHSQEPKDphdlMFTIHRSTGTISVISSgLDREKVPEYTLTI 298
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGE---NGEVTYSIVSGNEDG----LFSIDPSTGEITTAKP-LDREEQSSYTLTV 72

                        90       100
                ....*....|....*....|....*.
gi 14589891 299 QATDMDGDGSTTTAVAVVEILDANDN 324
Cdd:cd11304  73 TATDGGGPPLSSTATVTITVLDVNDN 98
CA_like super family cl46864
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 113-211 5.65e-25

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


The actual alignment was detected with superfamily member cd00031:

Pssm-ID: 481204  Cd Length: 98  Bit Score: 99.73  E-value: 5.65e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589891 113 PISVPENGKGPfpQRLNQLKSNKDRDTKIFYSITGPGADSPPeGVFAVEKETGWLLLNKPLDREEIAKYELFGHAVSENG 192
Cdd:cd00031   3 DGSAVEGRSRG--SFRVSIPTDLIASSGEIIKISAAGKEALP-SWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGA 79

                        90
                ....*....|....*....
gi 14589891 193 ASVEDPMNISIIVTDQNDH 211
Cdd:cd00031  80 NVPQTSSVFSIEVYDENDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 333-436 1.33e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.84  E-value: 1.33e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589891 333 YEAHVPENA-VGHEVQRLTVTDLDAPnsPAWRATYLIMGGDDGDHFTItthpESNQGILTTRKGLDFEAKNQHTLYVEVT 411
Cdd:cd11304   2 YEVSVPENApPGTVVLTVSATDPDSG--ENGEVTYSIVSGNEDGLFSI----DPSTGEITTAKPLDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|....*
gi 14589891 412 NEAPFVLklpTSTATIVVHVEDVNE 436
Cdd:cd11304  76 DGGGPPL---SSTATVTITVLDVND 97
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 765-824 1.71e-23

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


:

Pssm-ID: 460041  Cd Length: 60  Bit Score: 94.14  E-value: 1.71e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589891   765 ANTDPTAPPYDTLLVFDYEGSGSDAASLSSLTSSASDQDQDYDYLNEWGSRFKKLADMYG 824
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 446-544 1.62e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.43  E-value: 1.62e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589891 446 VVEVQEGIPTGEPVCVYTAEDPDK-ENQKISYRILR-DPAGWLAMDPDSGQVTAVGTLDREdeqfvRNNIYEVMVLAMDN 523
Cdd:cd11304   3 EVSVPENAPPGTVVLTVSATDPDSgENGEVTYSIVSgNEDGLFSIDPSTGEITTAKPLDRE-----EQSSYTLTVTATDG 77

                        90       100
                ....*....|....*....|.
gi 14589891 524 GSPPTTGTGTLLLTLIDVNDH 544
Cdd:cd11304  78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_pro super family cl07391
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 26-96 3.81e-03

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


The actual alignment was detected with superfamily member pfam08758:

Pssm-ID: 471661  Cd Length: 90  Bit Score: 37.30  E-value: 3.81e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 14589891    26 PCRAVFREAEVTLEAGgAEQEPGQALGKV-FMGCPGQEPALFSTDNDDFTVRNGETVQERRSLKERNPLKIF 96
Cdd:pfam08758   1 PCKPGFSEEVYTFSVP-RRLEEGQPLLNVkFNDCTGRKKTLYESSDPRFKVNTDGTVTAKRPVTLHGRQTSF 71
CA_like super family cl46864
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 551-638 9.40e-03

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


The actual alignment was detected with superfamily member pfam00028:

Pssm-ID: 481204 [Multi-domain]  Cd Length: 92  Bit Score: 36.12  E-value: 9.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589891   551 RQITICNQSPV---RQVLNITDKDLSPHTSPFQAQLTDDSDIYWTaeVNEegDTVVLSLKKFL---KQDTYDVHLSLSDH 624
Cdd:pfam00028   1 YSASVPENAPVgteVLTVTATDPDLGPNGRIFYSILGGGPGGNFR--IDP--DTGDISTTKPLdreSIGEYELTVEATDS 76

                          90
                  ....*....|....*.
gi 14589891   625 G--NKEQLTVIRATVC 638
Cdd:pfam00028  77 GgpPLSSTATVTITVL 92
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 219-324 1.39e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.01  E-value: 1.39e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589891 219 TFRGSVLEGVLPGTSVMQVTATDEDDAIytyNGVVAYSIHSQEPKDphdlMFTIHRSTGTISVISSgLDREKVPEYTLTI 298
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGE---NGEVTYSIVSGNEDG----LFSIDPSTGEITTAKP-LDREEQSSYTLTV 72

                        90       100
                ....*....|....*....|....*.
gi 14589891 299 QATDMDGDGSTTTAVAVVEILDANDN 324
Cdd:cd11304  73 TATDGGGPPLSSTATVTITVLDVNDN 98
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 113-211 5.65e-25

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 99.73  E-value: 5.65e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589891 113 PISVPENGKGPfpQRLNQLKSNKDRDTKIFYSITGPGADSPPeGVFAVEKETGWLLLNKPLDREEIAKYELFGHAVSENG 192
Cdd:cd00031   3 DGSAVEGRSRG--SFRVSIPTDLIASSGEIIKISAAGKEALP-SWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGA 79

                        90
                ....*....|....*....
gi 14589891 193 ASVEDPMNISIIVTDQNDH 211
Cdd:cd00031  80 NVPQTSSVFSIEVYDENDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 333-436 1.33e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.84  E-value: 1.33e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589891 333 YEAHVPENA-VGHEVQRLTVTDLDAPnsPAWRATYLIMGGDDGDHFTItthpESNQGILTTRKGLDFEAKNQHTLYVEVT 411
Cdd:cd11304   2 YEVSVPENApPGTVVLTVSATDPDSG--ENGEVTYSIVSGNEDGLFSI----DPSTGEITTAKPLDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|....*
gi 14589891 412 NEAPFVLklpTSTATIVVHVEDVNE 436
Cdd:cd11304  76 DGGGPPL---SSTATVTITVLDVND 97
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 765-824 1.71e-23

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 94.14  E-value: 1.71e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589891   765 ANTDPTAPPYDTLLVFDYEGSGSDAASLSSLTSSASDQDQDYDYLNEWGSRFKKLADMYG 824
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin pfam00028
Cadherin domain;
220-319 1.15e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 90.05  E-value: 1.15e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589891   220 FRGSVLEGVLPGTSVMQVTATDEDDaiyTYNGVVAYSIHSQEPKDphdlMFTIHRSTGTISVISSgLDREKVPEYTLTIQ 299
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDL---GPNGRIFYSILGGGPGG----NFRIDPDTGDISTTKP-LDRESIGEYELTVE 72

                          90       100
                  ....*....|....*....|
gi 14589891   300 ATDMDGDGSTTTAVAVVEIL 319
Cdd:pfam00028  73 ATDSGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 238-326 6.14e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 87.41  E-value: 6.14e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589891    238 TATDEDDAIytyNGVVAYSIHSQEPKDphdlMFTIHRSTGTISVISSgLDREKVPEYTLTIQATDMDGDGSTTTAVAVVE 317
Cdd:smart00112   1 SATDADSGE---NGKVTYSILSGNDDG----LFSIDPETGEITTTKP-LDREEQPEYTLTVEATDGGGPPLSSTATVTIT 72


                   ....*....
gi 14589891    318 ILDANDNAP 326
Cdd:smart00112  73 VLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
333-432 7.97e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 87.74  E-value: 7.97e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589891   333 YEAHVPENA-VGHEVQRLTVTDLDAPnsPAWRATYLIMGGDDGDHFTITTHPesnqGILTTRKGLDFEAKNQHTLYVEVT 411
Cdd:pfam00028   1 YSASVPENApVGTEVLTVTATDPDLG--PNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEAT 74

                          90       100
                  ....*....|....*....|.
gi 14589891   412 NEAPFVLklpTSTATIVVHVE 432
Cdd:pfam00028  75 DSGGPPL---SSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 446-544 1.62e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.43  E-value: 1.62e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589891 446 VVEVQEGIPTGEPVCVYTAEDPDK-ENQKISYRILR-DPAGWLAMDPDSGQVTAVGTLDREdeqfvRNNIYEVMVLAMDN 523
Cdd:cd11304   3 EVSVPENAPPGTVVLTVSATDPDSgENGEVTYSIVSgNEDGLFSIDPSTGEITTAKPLDRE-----EQSSYTLTVTATDG 77

                        90       100
                ....*....|....*....|.
gi 14589891 524 GSPPTTGTGTLLLTLIDVNDH 544
Cdd:cd11304  78 GGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
113-206 8.87e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 73.10  E-value: 8.87e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589891   113 PISVPENGK-GPFPQRLNQLKSNKDRDTKIFYSITGPGadspPEGVFAVEKETGWLLLNKPLDREEIAKYELFGHAVSEN 191
Cdd:pfam00028   2 SASVPENAPvGTEVLTVTATDPDLGPNGRIFYSILGGG----PGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                          90
                  ....*....|....*
gi 14589891   192 GASVEDPMNISIIVT 206
Cdd:pfam00028  78 GPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 350-438 2.19e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 71.61  E-value: 2.19e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589891    350 TVTDLDAPNSpaWRATYLIMGGDDGDHFTItthpESNQGILTTRKGLDFEAKNQHTLYVEVTNEAPFVLklpTSTATIVV 429
Cdd:smart00112   1 SATDADSGEN--GKVTYSILSGNDDGLFSI----DPETGEITTTKPLDREEQPEYTLTVEATDGGGPPL---SSTATVTI 71


                   ....*....
gi 14589891    430 HVEDVNEAP 438
Cdd:smart00112  72 TVLDVNDNA 80
Cadherin pfam00028
Cadherin domain;
446-527 2.42e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.95  E-value: 2.42e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589891   446 VVEVQEGIPTGEPVCVYTAEDPDKE-NQKISYRILRD-PAGWLAMDPDSGQVTAVGTLDREdeqfvRNNIYEVMVLAMDN 523
Cdd:pfam00028   2 SASVPENAPVGTEVLTVTATDPDLGpNGRIFYSILGGgPGGNFRIDPDTGDISTTKPLDRE-----SIGEYELTVEATDS 76


                  ....
gi 14589891   524 GSPP 527
Cdd:pfam00028  77 GGPP 80
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 463-546 3.08e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 65.83  E-value: 3.08e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589891    463 TAEDPDK-ENQKISYRILR-DPAGWLAMDPDSGQVTAVGTLDREDEQfvrnnIYEVMVLAMDNGSPPTTGTGTLLLTLID 540
Cdd:smart00112   1 SATDADSgENGKVTYSILSgNDDGLFSIDPETGEITTTKPLDREEQP-----EYTLTVEATDGGGPPLSSTATVTITVLD 75


                   ....*.
gi 14589891    541 VNDHGP 546
Cdd:smart00112  76 VNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 136-213 4.00e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 65.45  E-value: 4.00e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589891    136 DRDT----KIFYSITGPGADsppeGVFAVEKETGWLLLNKPLDREEIAKYELFGHAVSENGASVEDPMNISIIVTDQNDH 211
Cdd:smart00112   4 DADSgengKVTYSILSGNDD----GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                   ..
gi 14589891    212 KP 213
Cdd:smart00112  80 AP 81
Cadherin_pro pfam08758
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 26-96 3.81e-03

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 462590  Cd Length: 90  Bit Score: 37.30  E-value: 3.81e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 14589891    26 PCRAVFREAEVTLEAGgAEQEPGQALGKV-FMGCPGQEPALFSTDNDDFTVRNGETVQERRSLKERNPLKIF 96
Cdd:pfam08758   1 PCKPGFSEEVYTFSVP-RRLEEGQPLLNVkFNDCTGRKKTLYESSDPRFKVNTDGTVTAKRPVTLHGRQTSF 71
Cadherin pfam00028
Cadherin domain;
551-638 9.40e-03

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 36.12  E-value: 9.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589891   551 RQITICNQSPV---RQVLNITDKDLSPHTSPFQAQLTDDSDIYWTaeVNEegDTVVLSLKKFL---KQDTYDVHLSLSDH 624
Cdd:pfam00028   1 YSASVPENAPVgteVLTVTATDPDLGPNGRIFYSILGGGPGGNFR--IDP--DTGDISTTKPLdreSIGEYELTVEATDS 76

                          90
                  ....*....|....*.
gi 14589891   625 G--NKEQLTVIRATVC 638
Cdd:pfam00028  77 GgpPLSSTATVTITVL 92
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 219-324 1.39e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.01  E-value: 1.39e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589891 219 TFRGSVLEGVLPGTSVMQVTATDEDDAIytyNGVVAYSIHSQEPKDphdlMFTIHRSTGTISVISSgLDREKVPEYTLTI 298
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGE---NGEVTYSIVSGNEDG----LFSIDPSTGEITTAKP-LDREEQSSYTLTV 72

                        90       100
                ....*....|....*....|....*.
gi 14589891 299 QATDMDGDGSTTTAVAVVEILDANDN 324
Cdd:cd11304  73 TATDGGGPPLSSTATVTITVLDVNDN 98
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 113-211 5.65e-25

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 99.73  E-value: 5.65e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589891 113 PISVPENGKGPfpQRLNQLKSNKDRDTKIFYSITGPGADSPPeGVFAVEKETGWLLLNKPLDREEIAKYELFGHAVSENG 192
Cdd:cd00031   3 DGSAVEGRSRG--SFRVSIPTDLIASSGEIIKISAAGKEALP-SWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGA 79

                        90
                ....*....|....*....
gi 14589891 193 ASVEDPMNISIIVTDQNDH 211
Cdd:cd00031  80 NVPQTSSVFSIEVYDENDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 333-436 1.33e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.84  E-value: 1.33e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589891 333 YEAHVPENA-VGHEVQRLTVTDLDAPnsPAWRATYLIMGGDDGDHFTItthpESNQGILTTRKGLDFEAKNQHTLYVEVT 411
Cdd:cd11304   2 YEVSVPENApPGTVVLTVSATDPDSG--ENGEVTYSIVSGNEDGLFSI----DPSTGEITTAKPLDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|....*
gi 14589891 412 NEAPFVLklpTSTATIVVHVEDVNE 436
Cdd:cd11304  76 DGGGPPL---SSTATVTITVLDVND 97
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 765-824 1.71e-23

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 94.14  E-value: 1.71e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589891   765 ANTDPTAPPYDTLLVFDYEGSGSDAASLSSLTSSASDQDQDYDYLNEWGSRFKKLADMYG 824
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin pfam00028
Cadherin domain;
220-319 1.15e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 90.05  E-value: 1.15e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589891   220 FRGSVLEGVLPGTSVMQVTATDEDDaiyTYNGVVAYSIHSQEPKDphdlMFTIHRSTGTISVISSgLDREKVPEYTLTIQ 299
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDL---GPNGRIFYSILGGGPGG----NFRIDPDTGDISTTKP-LDRESIGEYELTVE 72

                          90       100
                  ....*....|....*....|
gi 14589891   300 ATDMDGDGSTTTAVAVVEIL 319
Cdd:pfam00028  73 ATDSGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 238-326 6.14e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 87.41  E-value: 6.14e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589891    238 TATDEDDAIytyNGVVAYSIHSQEPKDphdlMFTIHRSTGTISVISSgLDREKVPEYTLTIQATDMDGDGSTTTAVAVVE 317
Cdd:smart00112   1 SATDADSGE---NGKVTYSILSGNDDG----LFSIDPETGEITTTKP-LDREEQPEYTLTVEATDGGGPPLSSTATVTIT 72


                   ....*....
gi 14589891    318 ILDANDNAP 326
Cdd:smart00112  73 VLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
333-432 7.97e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 87.74  E-value: 7.97e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589891   333 YEAHVPENA-VGHEVQRLTVTDLDAPnsPAWRATYLIMGGDDGDHFTITTHPesnqGILTTRKGLDFEAKNQHTLYVEVT 411
Cdd:pfam00028   1 YSASVPENApVGTEVLTVTATDPDLG--PNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEAT 74

                          90       100
                  ....*....|....*....|.
gi 14589891   412 NEAPFVLklpTSTATIVVHVE 432
Cdd:pfam00028  75 DSGGPPL---SSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 446-544 1.62e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.43  E-value: 1.62e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589891 446 VVEVQEGIPTGEPVCVYTAEDPDK-ENQKISYRILR-DPAGWLAMDPDSGQVTAVGTLDREdeqfvRNNIYEVMVLAMDN 523
Cdd:cd11304   3 EVSVPENAPPGTVVLTVSATDPDSgENGEVTYSIVSgNEDGLFSIDPSTGEITTAKPLDRE-----EQSSYTLTVTATDG 77

                        90       100
                ....*....|....*....|.
gi 14589891 524 GSPPTTGTGTLLLTLIDVNDH 544
Cdd:cd11304  78 GGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
113-206 8.87e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 73.10  E-value: 8.87e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589891   113 PISVPENGK-GPFPQRLNQLKSNKDRDTKIFYSITGPGadspPEGVFAVEKETGWLLLNKPLDREEIAKYELFGHAVSEN 191
Cdd:pfam00028   2 SASVPENAPvGTEVLTVTATDPDLGPNGRIFYSILGGG----PGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                          90
                  ....*....|....*
gi 14589891   192 GASVEDPMNISIIVT 206
Cdd:pfam00028  78 GPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 350-438 2.19e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 71.61  E-value: 2.19e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589891    350 TVTDLDAPNSpaWRATYLIMGGDDGDHFTItthpESNQGILTTRKGLDFEAKNQHTLYVEVTNEAPFVLklpTSTATIVV 429
Cdd:smart00112   1 SATDADSGEN--GKVTYSILSGNDDGLFSI----DPETGEITTTKPLDREEQPEYTLTVEATDGGGPPL---SSTATVTI 71


                   ....*....
gi 14589891    430 HVEDVNEAP 438
Cdd:smart00112  72 TVLDVNDNA 80
Cadherin pfam00028
Cadherin domain;
446-527 2.42e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.95  E-value: 2.42e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589891   446 VVEVQEGIPTGEPVCVYTAEDPDKE-NQKISYRILRD-PAGWLAMDPDSGQVTAVGTLDREdeqfvRNNIYEVMVLAMDN 523
Cdd:pfam00028   2 SASVPENAPVGTEVLTVTATDPDLGpNGRIFYSILGGgPGGNFRIDPDTGDISTTKPLDRE-----SIGEYELTVEATDS 76


                  ....
gi 14589891   524 GSPP 527
Cdd:pfam00028  77 GGPP 80
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 463-546 3.08e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 65.83  E-value: 3.08e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589891    463 TAEDPDK-ENQKISYRILR-DPAGWLAMDPDSGQVTAVGTLDREDEQfvrnnIYEVMVLAMDNGSPPTTGTGTLLLTLID 540
Cdd:smart00112   1 SATDADSgENGKVTYSILSgNDDGLFSIDPETGEITTTKPLDREEQP-----EYTLTVEATDGGGPPLSSTATVTITVLD 75


                   ....*.
gi 14589891    541 VNDHGP 546
Cdd:smart00112  76 VNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 136-213 4.00e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 65.45  E-value: 4.00e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589891    136 DRDT----KIFYSITGPGADsppeGVFAVEKETGWLLLNKPLDREEIAKYELFGHAVSENGASVEDPMNISIIVTDQNDH 211
Cdd:smart00112   4 DADSgengKVTYSILSGNDD----GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                   ..
gi 14589891    212 KP 213
Cdd:smart00112  80 AP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 114-211 5.23e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 65.41  E-value: 5.23e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589891 114 ISVPENGkgPFPQRLNQLKSnKDRDT----KIFYSITGPgadsPPEGVFAVEKETGWLLLNKPLDREEIAKYELFGHAVS 189
Cdd:cd11304   4 VSVPENA--PPGTVVLTVSA-TDPDSgengEVTYSIVSG----NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATD 76

                        90       100
                ....*....|....*....|..
gi 14589891 190 ENGASVEDPMNISIIVTDQNDH 211
Cdd:cd11304  77 GGGPPLSSTATVTITVLDVNDN 98
Cadherin_pro pfam08758
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 26-96 3.81e-03

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 462590  Cd Length: 90  Bit Score: 37.30  E-value: 3.81e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 14589891    26 PCRAVFREAEVTLEAGgAEQEPGQALGKV-FMGCPGQEPALFSTDNDDFTVRNGETVQERRSLKERNPLKIF 96
Cdd:pfam08758   1 PCKPGFSEEVYTFSVP-RRLEEGQPLLNVkFNDCTGRKKTLYESSDPRFKVNTDGTVTAKRPVTLHGRQTSF 71
Cadherin pfam00028
Cadherin domain;
551-638 9.40e-03

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 36.12  E-value: 9.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589891   551 RQITICNQSPV---RQVLNITDKDLSPHTSPFQAQLTDDSDIYWTaeVNEegDTVVLSLKKFL---KQDTYDVHLSLSDH 624
Cdd:pfam00028   1 YSASVPENAPVgteVLTVTATDPDLGPNGRIFYSILGGGPGGNFR--IDP--DTGDISTTKPLdreSIGEYELTVEATDS 76

                          90
                  ....*....|....*.
gi 14589891   625 G--NKEQLTVIRATVC 638
Cdd:pfam00028  77 GgpPLSSTATVTITVL 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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